SE9604296D0 - New pharmaceutical formulation of polypeptides - Google Patents

New pharmaceutical formulation of polypeptides

Info

Publication number
SE9604296D0
SE9604296D0 SE9604296A SE9604296A SE9604296D0 SE 9604296 D0 SE9604296 D0 SE 9604296D0 SE 9604296 A SE9604296 A SE 9604296A SE 9604296 A SE9604296 A SE 9604296A SE 9604296 D0 SE9604296 D0 SE 9604296D0
Authority
SE
Sweden
Prior art keywords
lipid
pharmaceutical formulation
new pharmaceutical
polypeptides
relates
Prior art date
Application number
SE9604296A
Other languages
Swedish (sv)
Inventor
Thomas Berglindh
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9604296A priority Critical patent/SE9604296D0/en
Publication of SE9604296D0 publication Critical patent/SE9604296D0/en
Priority to PCT/SE1997/001927 priority patent/WO1998022135A1/en
Priority to AU51418/98A priority patent/AU5141898A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a new pharmaceutical formulation comprising a lipid aggregate of a negatively charged lipid or lipid mixture and at least one antigenic, native or recombinant polypeptide which constitute a Helicobacter pylori antigen, and optionally a pharmaceutically acceptable carrier. More specifically the invention relates to a lipid aggregate comprising a surface-exposed antigen with an approximate molecular weight of 29 kDa. Furthermore the invention provides a formulation of a nucleic acid molecule coding for the said polypeptide. The new formulations, which are useful as vaccine formulations, elicit a protective immune response against H. pylori infections, and said vaccine formulations are suitable for both therapeutic and prophylatic use.
SE9604296A 1996-11-22 1996-11-22 New pharmaceutical formulation of polypeptides SE9604296D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE9604296A SE9604296D0 (en) 1996-11-22 1996-11-22 New pharmaceutical formulation of polypeptides
PCT/SE1997/001927 WO1998022135A1 (en) 1996-11-22 1997-11-18 Pharmaceutical lipid aggregate with helicobacter pylori antigen and negatively charged lipid
AU51418/98A AU5141898A (en) 1996-11-22 1997-11-18 Pharmaceutical lipid aggregate with helicobacter pylori antigen and negatively charged lipid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9604296A SE9604296D0 (en) 1996-11-22 1996-11-22 New pharmaceutical formulation of polypeptides

Publications (1)

Publication Number Publication Date
SE9604296D0 true SE9604296D0 (en) 1996-11-22

Family

ID=20404716

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9604296A SE9604296D0 (en) 1996-11-22 1996-11-22 New pharmaceutical formulation of polypeptides

Country Status (3)

Country Link
AU (1) AU5141898A (en)
SE (1) SE9604296D0 (en)
WO (1) WO1998022135A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207646B1 (en) 1994-07-15 2001-03-27 University Of Iowa Research Foundation Immunostimulatory nucleic acid molecules
AU783344B2 (en) * 1999-02-17 2005-10-20 Csl Limited Immunogenic complexes and methods relating thereto
GB0008877D0 (en) * 2000-04-12 2000-05-31 Astrazeneca Ab Polypeptide delivery system
GB0008879D0 (en) * 2000-04-12 2000-05-31 Astrazeneca Ab Polypeptide delivery system
GB0010371D0 (en) * 2000-04-29 2000-06-14 Astrazeneca Ab Helicobacter pylori antigens
CN105816858A (en) 2007-12-28 2016-08-03 巴克斯特国际公司 Recombinant vwf formulations
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
WO2010041143A2 (en) * 2008-10-08 2010-04-15 Immune Solutions Limited Oral vaccines for producing mucosal immunity
CN102387784B (en) 2008-10-21 2014-04-02 巴克斯特国际公司 Lyophilized recombinant vwf formulations
CA3007036A1 (en) 2015-12-14 2017-06-22 Technische Universitat Munchen Helicobacter pylori vaccines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643574A (en) * 1993-10-04 1997-07-01 Albany Medical College Protein- or peptide-cochleate vaccines and methods of immunizing using the same

Also Published As

Publication number Publication date
AU5141898A (en) 1998-06-10
WO1998022135A1 (en) 1998-05-28

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