SE8102047L - INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, THEIR PREPARATION AND USE - Google Patents
INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, THEIR PREPARATION AND USEInfo
- Publication number
- SE8102047L SE8102047L SE8102047A SE8102047A SE8102047L SE 8102047 L SE8102047 L SE 8102047L SE 8102047 A SE8102047 A SE 8102047A SE 8102047 A SE8102047 A SE 8102047A SE 8102047 L SE8102047 L SE 8102047L
- Authority
- SE
- Sweden
- Prior art keywords
- hydrogen atom
- inhibitors
- preparation
- compounds
- cholesterol biosynthesis
- Prior art date
Links
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 235000012000 cholesterol Nutrition 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 241000228347 Monascus <ascomycete fungus> Species 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyrane Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Compounds of formula (I): <IMAGE> (in which R<1> and R<2>, which may be the same or different, each represents a hydrogen atom or an acyl group and R<3> represents a hydrogen atom or a methyl group, provided that, where R<1> represents a hydrogen atom, R<2> and R<3> cannot simultaneously be hydrogen atoms and R<2> cannot be a a- methylbutyryl group) inhibit the biosynthesis of cholesterol and hence can be used for the treatment of disorders resulting from high cholesterol levels. The compounds of the invention can be prepared by acylation of corresponding compounds where one or both of R<1> and R<2> represents a hydrogen atom and these may, in turn, be prepared by cultivation of microoorganisms of the genus Monascus.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55041292A JPH0692381B2 (en) | 1980-03-31 | 1980-03-31 | MB-530A derivative |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE8102047L true SE8102047L (en) | 1981-10-01 |
| SE461590B SE461590B (en) | 1990-03-05 |
Family
ID=12604367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE8102047A SE461590B (en) | 1980-03-31 | 1981-03-31 | DERIVATIVES OF 6-HEXAHYDRONAFTYLETHYL-4-HYDROXY-TETRAHYDROPYRENE-2-ON, PROCEDURES FOR PREPARING THESE AND A PHARMACEUTICAL COMPOSITION FOR USE FOR INHIBITION OF CHOLESTEROL |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPH0692381B2 (en) |
| AT (1) | ATA150781A (en) |
| AU (1) | AU6893281A (en) |
| BE (1) | BE888214A (en) |
| CH (1) | CH646966A5 (en) |
| DE (2) | DE3112566A1 (en) |
| DK (3) | DK151273C (en) |
| FI (1) | FI810991L (en) |
| FR (1) | FR2479222A1 (en) |
| GB (1) | GB2073193A (en) |
| IE (1) | IE52367B1 (en) |
| IT (1) | IT1144325B (en) |
| MX (1) | MX9203567A (en) |
| NL (1) | NL8101592A (en) |
| SE (1) | SE461590B (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4472426A (en) * | 1982-12-22 | 1984-09-18 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| DE3682557D1 (en) * | 1985-09-13 | 1992-01-02 | Sankyo Co | HYDROXY-ML-236B DERIVATIVES, THEIR PRODUCTION AND USE. |
| US4997848A (en) | 1987-10-27 | 1991-03-05 | Sankyo Company, Limited | Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition |
| US5075327A (en) * | 1988-08-10 | 1991-12-24 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
| US5021451A (en) * | 1988-11-14 | 1991-06-04 | Hoffman-La Roche Inc. | Method for inhibiting hyperproliferative diseases |
| US5200549A (en) * | 1988-11-14 | 1993-04-06 | Hoffman-La Roche Inc. | Antipsoriatic agents |
| US5073568A (en) * | 1988-11-14 | 1991-12-17 | Hoffmann-La Roche Inc. | Antipsoriatic agents |
| US5159104A (en) * | 1991-05-01 | 1992-10-27 | Merck & Co., Inc. | Process to simvastatin ester |
| FR2937537A1 (en) | 2008-10-29 | 2010-04-30 | Centre Nat Rech Scient | NANOPARTICLES OF STATIN |
| KR101820099B1 (en) | 2013-01-18 | 2018-01-18 | 에스프린팅솔루션 주식회사 | resistive heat generating material, heating member and fusing device adopting the same |
| RU2020126177A (en) | 2018-01-09 | 2022-02-10 | Лиганд Фармасьютикалз, Инк. | ACETAL COMPOUNDS AND THEIR THERAPEUTIC APPLICATIONS |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5612114B2 (en) * | 1974-06-07 | 1981-03-18 | ||
| JPS5925599B2 (en) * | 1979-02-20 | 1984-06-19 | 三共株式会社 | New physiologically active substance monacolin K and its production method |
| US4231938A (en) * | 1979-06-15 | 1980-11-04 | Merck & Co., Inc. | Hypocholesteremic fermentation products and process of preparation |
| AU535944B2 (en) * | 1979-06-15 | 1984-04-12 | Merck & Co., Inc. | Hypocholestermic fermentation products from aspergillus |
| US4282155A (en) * | 1980-02-04 | 1981-08-04 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| PT72394B (en) * | 1980-02-04 | 1982-09-06 | Merck & Co Inc | Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics |
| ZA81703B (en) * | 1980-02-04 | 1982-09-29 | Merck & Co Inc | New antihypercholesterolemic compounds,intermediates and processes |
| AU548996B2 (en) * | 1980-02-04 | 1986-01-09 | Merck & Co., Inc. | Tetrahydro-2h-pyran-2-one derivatives |
-
1980
- 1980-03-31 JP JP55041292A patent/JPH0692381B2/en not_active Expired - Lifetime
-
1981
- 1981-03-27 IE IE698/81A patent/IE52367B1/en not_active IP Right Cessation
- 1981-03-30 DE DE19813112566 patent/DE3112566A1/en active Granted
- 1981-03-30 IT IT67438/81A patent/IT1144325B/en active
- 1981-03-30 CH CH215381A patent/CH646966A5/en not_active IP Right Cessation
- 1981-03-30 DE DE3153666A patent/DE3153666C2/en not_active Expired - Lifetime
- 1981-03-31 FR FR8106403A patent/FR2479222A1/en active Granted
- 1981-03-31 AT AT0150781A patent/ATA150781A/en not_active IP Right Cessation
- 1981-03-31 DK DK145481A patent/DK151273C/en not_active IP Right Cessation
- 1981-03-31 FI FI810991A patent/FI810991L/en not_active Application Discontinuation
- 1981-03-31 NL NL8101592A patent/NL8101592A/en not_active Application Discontinuation
- 1981-03-31 SE SE8102047A patent/SE461590B/en not_active Application Discontinuation
- 1981-03-31 BE BE0/204328A patent/BE888214A/en not_active IP Right Cessation
- 1981-03-31 GB GB8110075A patent/GB2073193A/en not_active Withdrawn
- 1981-03-31 AU AU68932/81A patent/AU6893281A/en not_active Abandoned
-
1990
- 1990-02-07 DK DK032290A patent/DK32290D0/en not_active Application Discontinuation
- 1990-02-07 DK DK032190A patent/DK167805B1/en not_active IP Right Cessation
-
1992
- 1992-06-26 MX MX9203567A patent/MX9203567A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATA150781A (en) | 1983-03-15 |
| FR2479222A1 (en) | 1981-10-02 |
| IE52367B1 (en) | 1987-09-30 |
| DK32190A (en) | 1990-02-07 |
| DK167805B1 (en) | 1993-12-20 |
| DK32290A (en) | 1990-02-07 |
| IT1144325B (en) | 1986-10-29 |
| DE3112566A1 (en) | 1982-03-11 |
| DE3112566C2 (en) | 1990-04-05 |
| AU6893281A (en) | 1981-10-08 |
| JPH0692381B2 (en) | 1994-11-16 |
| CH646966A5 (en) | 1984-12-28 |
| FI810991L (en) | 1981-10-01 |
| DK151273B (en) | 1987-11-16 |
| MX9203567A (en) | 1992-09-01 |
| GB2073193A (en) | 1981-10-14 |
| DK32290D0 (en) | 1990-02-07 |
| IT8167438A0 (en) | 1981-03-30 |
| DK151273C (en) | 1988-07-04 |
| DK145481A (en) | 1981-10-01 |
| FR2479222B1 (en) | 1983-08-26 |
| JPS56138181A (en) | 1981-10-28 |
| DK32190D0 (en) | 1990-02-07 |
| BE888214A (en) | 1981-09-30 |
| SE461590B (en) | 1990-03-05 |
| DE3153666C2 (en) | 1993-11-11 |
| IE810698L (en) | 1981-09-30 |
| NL8101592A (en) | 1981-10-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAV | Patent application has lapsed |
Ref document number: 8102047-1 |