SE0401951D0 - Chromatography method - Google Patents

Chromatography method

Info

Publication number
SE0401951D0
SE0401951D0 SE0401951A SE0401951A SE0401951D0 SE 0401951 D0 SE0401951 D0 SE 0401951D0 SE 0401951 A SE0401951 A SE 0401951A SE 0401951 A SE0401951 A SE 0401951A SE 0401951 D0 SE0401951 D0 SE 0401951D0
Authority
SE
Sweden
Prior art keywords
functional groups
pegylated
compounds
pegylated compound
interaction
Prior art date
Application number
SE0401951A
Other languages
Swedish (sv)
Inventor
James Van Alstine
Jan Bergstroem
Dag Lindstroem
Tobias Soederman
Joachim Stadler
Original Assignee
Amersham Biosciences Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Ab filed Critical Amersham Biosciences Ab
Priority to SE0401951A priority Critical patent/SE0401951D0/en
Publication of SE0401951D0 publication Critical patent/SE0401951D0/en
Priority to PCT/SE2005/001134 priority patent/WO2006011839A1/en

Links

Abstract

The present invention relates to a method for purification of least one pegylated compound, which comprises to provide a separation matrix comprised of a porous support, which presents an average pore radius of at least 40 nm and to the surfaces of which functional groups have been immobilised; and to contact said matrix with a liquid that comprises pegylated compound(s) to allow interaction of one or more such compounds with the functional groups; and to recovering pegylated compound(s) as one or more fractions. The interaction is provided at functional groups located at the outer surface as well as located on the pore surfaces of the support. Thus, the porosity of the separation matrix allows for the pegylated compounds to enter the pores.
SE0401951A 2004-07-29 2004-07-29 Chromatography method SE0401951D0 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SE0401951A SE0401951D0 (en) 2004-07-29 2004-07-29 Chromatography method
PCT/SE2005/001134 WO2006011839A1 (en) 2004-07-29 2005-07-08 Chromatography method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0401951A SE0401951D0 (en) 2004-07-29 2004-07-29 Chromatography method

Publications (1)

Publication Number Publication Date
SE0401951D0 true SE0401951D0 (en) 2004-07-29

Family

ID=32867311

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0401951A SE0401951D0 (en) 2004-07-29 2004-07-29 Chromatography method

Country Status (2)

Country Link
SE (1) SE0401951D0 (en)
WO (1) WO2006011839A1 (en)

Families Citing this family (21)

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Publication number Priority date Publication date Assignee Title
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
PL1615945T3 (en) 2003-04-09 2012-03-30 Ratiopharm Gmbh Glycopegylation methods and proteins/peptides produced by the methods
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
EP1771066A2 (en) 2004-07-13 2007-04-11 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 glp-1
WO2006050247A2 (en) 2004-10-29 2006-05-11 Neose Technologies, Inc. Remodeling and glycopegylation of fibroblast growth factor (fgf)
NZ556436A (en) 2005-01-10 2010-11-26 Biogenerix Ag Glycopegylated granulocyte colony stimulating factor
EP2386571B1 (en) 2005-04-08 2016-06-01 ratiopharm GmbH Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
ES2516694T3 (en) 2006-07-21 2014-10-31 Ratiopharm Gmbh Glycosylation of peptides through glycosylation sequences with O-binding
WO2008057683A2 (en) 2006-10-03 2008-05-15 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
BRPI0809670A8 (en) 2007-04-03 2018-12-18 Biogenerix Ag methods to increase stem cell production, to increase the number of granulocytes in an individual, to prevent, treat and alleviate myelosuppression that results from cancer therapy, to treat a condition in an individual, to treat neutropenia and thrombocytopenia in a mammal, to expand hematopoietic stem cells in culture, to increase hematopoiesis in an individual, to increase the number of hematopoietic progenitor cells in an individual, and to provide stable bone marrow graft, and, oral dosage form.
CN101778859B (en) 2007-06-12 2014-03-26 诺和诺德公司 Improved process for the production of nucleotide sugars
AR067536A1 (en) 2007-07-17 2009-10-14 Hoffmann La Roche METHOD FOR OBTAINING A MONO-PEGILATED ERYTHROPOYETIN IN A SUBSTANTIALLY HOMOGENOUS FORM
CL2008002053A1 (en) 2007-07-17 2009-05-22 Hoffmann La Roche Method for the purification of a monopeglated erythropoietin (epompeg) which consists of providing a solution containing mono, poly and non-peglated erythropoietin and passing it through two steps of cation exchange chromatography and a method to produce epo mpeg that includes a purification method.
CN103497246B (en) 2008-02-27 2016-08-10 诺沃—诺迪斯克有限公司 The Factor VlII molecule puted together
JP5735650B2 (en) 2010-09-14 2015-06-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Method for purifying PEGylated erythropoietin
DE102011101995A1 (en) 2011-05-19 2012-11-22 Sartorius Stedim Biotech Gmbh Process for separating a mixture of a protein and its reaction product with a polyalkylene glycol

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2761881B2 (en) * 1988-03-10 1998-06-04 チッソ株式会社 An antibody-immobilized carrier for affinity chromatography
US6025324A (en) * 1996-05-15 2000-02-15 Hoffmann-La Roche Inc. Pegylated obese (ob) protein compositions
WO1998039467A2 (en) * 1997-03-03 1998-09-11 Calydon, Inc. Adenovirus vectors specific for cells expressing carcinoembryonic antigen and methods of use thereof
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides

Also Published As

Publication number Publication date
WO2006011839A1 (en) 2006-02-02

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