SE0203552D0 - Thrombin concentration - Google Patents
Thrombin concentrationInfo
- Publication number
- SE0203552D0 SE0203552D0 SE0203552A SE0203552A SE0203552D0 SE 0203552 D0 SE0203552 D0 SE 0203552D0 SE 0203552 A SE0203552 A SE 0203552A SE 0203552 A SE0203552 A SE 0203552A SE 0203552 D0 SE0203552 D0 SE 0203552D0
- Authority
- SE
- Sweden
- Prior art keywords
- thrombin solution
- thrombin
- solution
- relates
- initial
- Prior art date
Links
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
One aspect of the invention relates to a process for the preparation of a concentrated thrombin solution from an initial thrombin solution obtainable by activation of a prothrombin solution, which process comprises subjecting such an initial thrombin solution to the following consecutive steps: (a) heat treatment and (b) hydrophobic interaction chromatography on an aliphatic adsorbent. Another aspect of the invention relates to a thrombin solution having a thrombin concentration higher than about 100,000 IU/ml. A further aspect of the invention relates to the use of a thrombin solution in a component for a fibrin glue.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0203552A SE0203552D0 (en) | 2002-12-02 | 2002-12-02 | Thrombin concentration |
AU2003267906A AU2003267906A1 (en) | 2002-12-02 | 2003-10-06 | Process for preparating concentrated thrombin solutions and use in fibrin glue |
PCT/SE2003/001548 WO2004050700A1 (en) | 2002-12-02 | 2003-10-06 | Process for preparating concentrated thrombin solutions and use in fibrin glue |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0203552A SE0203552D0 (en) | 2002-12-02 | 2002-12-02 | Thrombin concentration |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0203552D0 true SE0203552D0 (en) | 2002-12-02 |
Family
ID=20289727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0203552A SE0203552D0 (en) | 2002-12-02 | 2002-12-02 | Thrombin concentration |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2003267906A1 (en) |
SE (1) | SE0203552D0 (en) |
WO (1) | WO2004050700A1 (en) |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE59712322D1 (en) * | 1996-03-20 | 2005-06-30 | Baxter Ag | Pharmaceutical preparation for the treatment of blood clotting disorders |
DE10012732A1 (en) * | 2000-03-18 | 2001-09-20 | Aventis Behring Gmbh | Thrombin composition, for use as hemostatic or as a component of fibrin glues, comprises non-covalently bonded inhibitor for stabilization |
-
2002
- 2002-12-02 SE SE0203552A patent/SE0203552D0/en unknown
-
2003
- 2003-10-06 AU AU2003267906A patent/AU2003267906A1/en not_active Abandoned
- 2003-10-06 WO PCT/SE2003/001548 patent/WO2004050700A1/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2003267906A1 (en) | 2004-06-23 |
WO2004050700A1 (en) | 2004-06-17 |
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