SE0202461D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE0202461D0
SE0202461D0 SE0202461A SE0202461A SE0202461D0 SE 0202461 D0 SE0202461 D0 SE 0202461D0 SE 0202461 A SE0202461 A SE 0202461A SE 0202461 A SE0202461 A SE 0202461A SE 0202461 D0 SE0202461 D0 SE 0202461D0
Authority
SE
Sweden
Prior art keywords
novel compounds
compounds
racemates
tautomers
inhibitors
Prior art date
Application number
SE0202461A
Other languages
Swedish (sv)
Inventor
Jan Dahmen
Martin Hemmerling
Tomas Klingstedt
Peter Sjoe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0202461A priority Critical patent/SE0202461D0/en
Publication of SE0202461D0 publication Critical patent/SE0202461D0/en
Priority to PCT/SE2003/001278 priority patent/WO2004016615A1/en
Priority to AU2003258922A priority patent/AU2003258922A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

There are provided novel compounds of formula (I) wherein R and X are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the kinase Itk.
SE0202461A 2002-08-14 2002-08-14 Novel compounds SE0202461D0 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
SE0202461A SE0202461D0 (en) 2002-08-14 2002-08-14 Novel compounds
PCT/SE2003/001278 WO2004016615A1 (en) 2002-08-14 2003-08-13 PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY
AU2003258922A AU2003258922A1 (en) 2002-08-14 2003-08-13 PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0202461A SE0202461D0 (en) 2002-08-14 2002-08-14 Novel compounds

Publications (1)

Publication Number Publication Date
SE0202461D0 true SE0202461D0 (en) 2002-08-14

Family

ID=20288749

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0202461A SE0202461D0 (en) 2002-08-14 2002-08-14 Novel compounds

Country Status (3)

Country Link
AU (1) AU2003258922A1 (en)
SE (1) SE0202461D0 (en)
WO (1) WO2004016615A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
ES2391472T3 (en) * 2005-12-20 2012-11-27 Astrazeneca Ab Substituted cinnoline derivatives as GABAA receptor modulators and method for their synthesis
WO2007126913A1 (en) * 2006-03-27 2007-11-08 The Government Of The U.S.A. As Represented By The Secretary Department Of Health & Human Services Methods for prevention or treatment of viral disease
WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors
KR102452866B1 (en) 2013-10-25 2022-10-07 파마싸이클릭스 엘엘씨 Methods of treating and preventing graft versus host disease
CN108135904A (en) 2015-08-31 2018-06-08 药品循环有限责任公司 For treating the combination of the BTK inhibitor of Huppert's disease
CA3042049A1 (en) 2016-11-03 2018-05-11 Juno Therapeutics, Inc. Combination therapy of a t cell therapy and a btk inhibitor
BR112019028181A2 (en) 2017-06-30 2020-07-07 Bayer Animal Health Gmbh new azaquinoline derivatives
EP3787751A1 (en) 2018-05-03 2021-03-10 Juno Therapeutics, Inc. Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549833B1 (en) * 1983-07-26 1985-11-08 Roussel Uclaf PYRAZOLO / 4,3-C / CINNOLIN-3-ONE DERIVATIVES, SALTS THEREOF, PROCESS FOR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES
JPS61112075A (en) * 1984-11-05 1986-05-30 Shionogi & Co Ltd Thienylpyrazoloquinoline derivative
US4591589A (en) * 1985-01-16 1986-05-27 Roussel Uclaf 2-aryl pyrazolo[4,3-c]cinnolin-3-ones

Also Published As

Publication number Publication date
AU2003258922A1 (en) 2004-03-03
WO2004016615A1 (en) 2004-02-26

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