RU2710499C1 - Method for color correction of cerebral neurrometabolism disorders - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention relates to biology and medicine, in particular to neurophysiological methods for correction of brain disorders using optical systems, and can be used in neurology, psychiatry, speech therapy and defectology. Prior to selecting the lenses, the patient is registered with a background level of the permanent cerebral potential (LPP) in the frontal, central, occipital, right and left temporal regions. Lenses are selected by carrying a patient with a holder with successively fixed pairs of test lenses with continuous registration of the cerebral LPP in the frontal, central, occipital, right and left temporal regions for each analyzed pair of lenses for a time until achieving stable values of constant potentials with a drift more than 2 mV for 10 minutes. Result of the level of LPP is recorded at the last minute of measurements. Rest is performed after checking each pair of lenses. Arithmetic mean value is determined for the background LPP for all 5 detection regions (Xav background, mV) and the arithmetic mean value for the LPP after the holder with each pair of lenses is worn on all 5 detection regions (Xav sample, mV). Further, the percentage of change of average LPP (K, %) is calculated using the claimed formula. If the value of K is at least in one detection region of 30 % and more, and the LPP is detected in one or more detection regions within 7 to 15 mV, the lenses are considered to be finally selected and recommended for wearing during the patient's wake. Periodically, control measurements of LPP – in a week, half a year and year after wearing of lenses, with implementation of additional corrective selection of lenses.

EFFECT: method enables providing more effective correction of cerebral metabolic activity disorders in various states – dyslexia, dysgraphia, visual agnosia, scotopic sensitivity syndrome, autism, mental retardation and other disorders caused by cerebral dysfunctions, due to objective assessment of cerebral neurrometabolism changes in selection of colored lenses with different degree of light absorption and in the process of their wearing.

3 cl, 6 dwg, 4 tbl, 2 ex

Description

The invention relates to the field of biology and medicine, in particular, to neurophysiological methods for the correction of brain disorders using optical systems and can be used in neurology, psychiatry, speech therapy and defectology in the correction of neurometabolism of the cerebral cortex.

Impaired functioning of certain areas of the brain entails severe consequences, for example, in case of a violation of the functional activity of the visual zones of the cerebral cortex, visual perception disorders, scotopic sensitivity syndrome (Irlen's syndrome), dyslexia, dysgraphia, visual agnosia, sensitivity to light, etc. can occur. d.

People with impaired functional activity of the cerebral cortex may be disturbed by problems with concentration, reading difficulties, fragmentation (mosaic) of perception, impaired coordination, autonomic symptoms of stress, headache and migraine. Most of the symptoms are subjective and cannot be accurately measured, especially in young children and people with mental disorders.

The correction of these problems is carried out using various methods and devices, for example, using the method of individual selection of colored lenses for glasses, text overlays, as well as lighting devices with the ability to change the spectrum of the emitted light.

To correct, in particular, symptoms of dyslexia and reading disorders, the use of various optical systems is known.

Thus, an optical system for the treatment of dyslexia is known, which consists of a pair of lenses, one of which is transparent for use in combination with one eye of the patient, and the other has a colored part that must be used in conjunction with the other eye of the patient. When a patient looks at a target surface, usually white, through a lens system, the image interpreted by the patient’s brain changes from the original color corresponding to the color of the colored lens to the color of the target surface, and after this treatment the patient can read without visual disturbance associated with dyslexia (GB 2266786; G02C 5/00, G02C 7/10, G02C 7/10; 11/10/1993).

Partially closed contact lenses are known for treating visual and / or brain disorders by accurately, completely and selectively blocking the visual entrance to part of the retina and brain using contact lenses or special lenses. (US 6062687 A; G02C 7/027, G02C 7/04, G02C 7/048, G02C 7/16, G02C 2202/10; 05.16.2000).

Methods and devices are also known for diagnosing and correcting visual impairment and other pathological conditions associated with impaired human brain activity.

For example, there is a known method for improving accuracy and eliminating color vision defects using tinted filters placed between the eye and the object. Filters are selected individually (DE 19804703 A1; A61B 3/06, G02C 7/10, A61B 3/06; A61F 9/00, G02C 7/10; 21.10. 1999).

A known method of testing and correcting visual function by placing over the text a tinted transparent layer of a variable shade to alleviate the symptoms of visual dyslexia and other optical disorders. A quantitative approach is used to identify the colorimetric parameter in three dimensions of color space, a short series of tests on different colorimetric parameters allows you to find the optimal color combination (US 6729729 B1; A61B 3/06, A61F 9/00, A61B 3/02; 04.05.2004).

A known method of diagnosing and alleviating the symptoms of visually induced physiological defects and pathological conditions (visual dyslexia, macular degeneration and light-induced migraine) using a lighting device to create lighting with certain defined characteristics (US 20030223036 A1; A61B 3/06; A61N 5/06 ; A61B 3/10; 12/04/2003).

A known method for assessing the effect of tinted lighting on the visual system of a patient and equipment for its implementation, according to which, the color of the controlled light sources provides background illumination; the patient can influence the movement of an object, for example, a symbol or a ball, and examines the object in various positions or in movement, with the choice of the color of lighting visually comfortable for perception. This method is used to select a color shade for people suffering from dyslexia or other disorders of the visual system in order to increase visual performance (US 20060262272 A1; A61B 3/10; 11/23/2006).

A known method and apparatus for diagnosing and eliminating reading disorders by respectively measuring and improving contrast sensitivity to discriminate subject movement. The background is displayed on a monitor with contrast and spatial frequency. A test window is overlaid on top of the background and includes a test pattern with contrast and spatial frequency. Contrasts and spatial frequencies are in the corresponding ranges that stimulate the visual cortical system of movement of the object. Then the test pattern is moved within the test window. The subject gives a signal indicating the direction in which, according to the subject, the test sample was moving. Contrast sensitivity can be measured to determine the presence of dyslexia. Repeated stimulation increases contrast sensitivity, thereby eliminating dyslexia and improving reading ability (US 6045515A; A61B 3/06; A61H 5/00; G06F 19/00; A61B 3/032; A61B 13/00; 04.04.2000).

A known method and apparatus for reducing visual stress and dyslexia, according to which the subject is offered a visual numerical test, the inability to complete which within a given time indicates the likelihood that a person has visual stress or dyslexia. Correction of violations is carried out using regulated ambient lighting with a special lamp of variable color temperature (US 5420653 A, A61B 3/028; A61B 3/032; A61B 3/00; A61B 3/02; 05/30/1995).

The disadvantages of all known devices and methods for diagnosing and correcting disorders associated with impaired functioning and metabolism of the cerebral cortex include their lack of effectiveness due to the following factors:

- there are no objective criteria for the selection of corrective devices - the choice of corrective devices in all cases is based on the results and interpretation by patients of subjective feelings of comfort and discomfort, as well as on monitoring the patient's behavior, his reactions;

- the complexity and inaccuracy of the diagnosis and / or determination of the achievement of the therapeutic effect or its absence in children and adults with severe behavioral, speech and intellectual impairment (due to the need for feedback from the patient);

- the process of selecting a color stimulus does not take into account external factors (room illumination, monitor screen settings, patient condition, etc.);

- there is no assessment of the effect of applying the correction on the patient’s nervous system, in particular, on the cerebral cortex.

Moreover, there is a method for evaluating spectacle lenses by means of the induced activity of the visual cortex of the brain (RU 2615123 C2; A61B 3/10, A61B 5/0476, G02C 7/02; 07.27.2016), according to which the subject wears lenses that must be evaluated . Present visual object-stimulus of various configurations in various fields of view. Visual evoked activity is recorded and visual evoked potential of the primary and secondary visual cortex is secreted. Evaluation of the lens is carried out according to the measurement of visual evoked field, amplitude and latent period of the visual evoked potential and its components.

This method makes it possible to objectively evaluate spectacle lenses suitable for the consumer by measuring brain activity, but the method does not involve the correction of neurometabolism in the cerebral cortex and has the following disadvantages:

- requires expensive specific medical equipment (306-channel magnetoencephalograph);

- data interpretation requires highly qualified training of specialists;

- the interpretation of evoked potentials does not make it possible to assess the level of energy metabolism in various areas of the cerebral cortex. In addition, the type of evoked potentials used cannot be used to assess the functions of the central nervous system in young children, patients with pathology of the eyes, optic nerves, genetic syndromes, impaired consciousness and severe cognitive impairment.

Closest to the claimed method is a method and device for treating the symptoms of Irlen syndrome (US 4961640A; A61B 3/06, G02C 5/00, G02C 7/10, A61B 3/00, G02C 7/10; 10/09/1990), according to which To correct violations of the processing of visual information, special tinted lenses are used. The method includes empirical selection of spectacle lenses of a certain color and optical density with a given absorption property of 60% or more of light with a wavelength in the range of 425-575 nm. The exact shade and its density, necessary to alleviate the symptoms, are individually selected for each patient. Wearing glasses with selected lenses helps to remove perceptual disorders and, in particular, symptoms of dyslexia and other learning disorders associated with it.

The disadvantages of this method is the high degree of subjectivity in the selection of the optimal combination of colored spectacle lenses, the lack of clear criteria for assessing the neurophysiological effect of lenses on the metabolism of the brain in general and the visual cortex in particular, the inability to use the method for children and adults with severe behavioral, speech and / or intellectual impairments that often accompany brain disorders.

The objective of the invention is to increase the efficiency of color correction of disorders of the neurometabolism of the cerebral cortex using individual selection and wearing colored spectacle lenses with varying degrees of light absorption.

The technical result of the claimed correction method is expressed in increasing the color correction of neurometabolism disorders of the cerebral cortex due to the accuracy and scientific justification of the selection of colored spectacle lenses with varying degrees of light absorption, contributing to the normalization of metabolism in the cerebral cortex of patients, including adults and children with severe speech, intellectual and behavioral disorders.

The technical result is achieved by the fact that in the method of color correction of disorders of the neurometabolism of the cerebral cortex, including the patient wearing individually selected colored spectacle lenses with different degrees of light absorption, according to the claimed invention, prior to selecting the lenses, the patient is registered with the background level of the constant brain potential (SCP) in the frontal , central, occipital, right and left temporal areas; the selection of lenses is carried out by putting on the patient’s frames with pairs of test lenses alternately fixed on it with continuous recording of the level of constant potential of the brain (SCP) in the frontal, central, occipital, right and left temporal regions for each pair of lenses studied for a time until stable values of constant potentials with a drift of not more than 2 mV in 10 minutes, with fixing the results of the SCP level at the last minute of measurements, and rest after checking each pair of lenses, the results of the registration of the SCP values for each area of the brain before selecting lenses and after wearing a rim with each pair of lenses are compared with the reference for a given age and gender and for each lens pair the average level of constant potential for all recorded areas is calculated, with the calculation of the percentage change in the average level of constant potential, according to the formula:

K = (Xsr sample - Khsr background / Khsr sample) * 100%,

where: K is the percentage change in the average level of constant potential after wearing a test lens sample;

Hsr von - average level of constant potential (arithmetic average of the background SCP values for all 5 registration points obtained before wearing the lens sample);

Хср sample - average level of constant potential (arithmetic average of SCP values for all 5 registration points obtained after wearing a lens sample); with shifts of the average level of constant potentials in at least one recording zone, and the percentage change in the average value by 30% or more towards approximation of the reference values and the establishment of SCP in one or more of the recording region in the range from 7 to 15 mV, lenses consider finally selected and recommended for wearing while the patient is awake, followed by control measurements of SCP in a week, six months and a year after wearing lenses and the necessary additional correction.

In the method of color correction of disorders of the neurometabolism of the cerebral cortex, lenses obtained by applying several differently colored lenses with different degrees of light absorption can be recommended for continuous use.

In the method of color correction of disorders of the neurometabolism of the cerebral cortex, lenses can be recommended for continuous wearing, the selection of which is carried out by focusing the patient’s gaze on visual stimuli, which are a noisy image with high contrast and a large number of small details (stripes, patterns) or text printed on a sheet white paper in small black print, while using visual stimuli that cause changes in the average SCP by more than ± 8 mV from the reference value.

The measurement of the level of constant potentials (SCP) reflects the state of the acid-base state at the border of the blood-brain barrier and allows us to assess the state of utilization (metabolism) of glucose by the brain and the state of its energy activity.

Obtained in the process of implementing the method, the SCP values for each region of the brain and the average value indicate a change in metabolism in the cerebral cortex before and after wearing selected lenses and show the degree of deviation of the SCP values in the measured areas from the values accepted as reference ones.

The method of color correction of disorders of the neurometabolism of the cerebral cortex is illustrated by the following materials.

In FIG. 1 shows an example of a visual stimulus in the form of a noisy high-contrast image with a large number of small details (stripes, patterns) used in the selection of lenses;

In FIG. Figure 2 shows the neurocard of the brain of a patient with atypical autism (boy, 6 years old), obtained before the selection of lenses.

In FIG. Figure 3 shows the neurocard of the brain of a patient with atypical autism (boy, 6 years old), obtained after 10 min. wearing specially selected lenses.

In FIG. Figure 4 shows the neurocard of the patient’s brain (female, 50 years old) obtained by examining a noisy image without lenses.

In FIG. Figure 5 shows a neurocard of the brain of a patient with migraine, blurred vision, problems with spatial orientation (woman, 50 years old), obtained by examining a noisy image in lenses.

In FIG. Figure 6 shows the optical absorption spectra of some lenses (L-R79 - red-orange, L-V259 - purple-pink, L-N85 - brown, L-P53 - pink).

The positions in the noisy picture (Fig. 1) show: the image of the panda - 1, strokes - 2.

The method is as follows.

In a patient with impaired neurometabolism of the cerebral cortex, identified as a result of medical (neurological, neuropsychological), psychological and pedagogical examinations, manifestations of which, for example, are sensory and cognitive impairments, assess the level of metabolism of the cerebral cortex by recording the background level of constant potentials (SCP). Registration of SCP is carried out monopolarly using active silver-silver cup electrodes for EEG and a reference reference electrode of the type “EVL-1-M4”. Before registration, they are pre-tested in a hypertonic (30%) NaCl solution in order to measure the potential difference and resistance between the electrodes in the absence of the object of study. The potential difference between the electrodes should be less than 20 mV, and the interelectrode resistance of 15 to 20 kOhm. Before installing the electrodes, their surface and skin at the location of the electrodes are degreased with a 70% alcohol solution. In places where electrodes are applied to the skin, cotton swabs moistened with a hypertonic (30%) NaCl solution are placed. The reference electrode is placed on the wrist of the leading arm, the active electrodes are along the sagittal line according to the international system "10-20" in the following leads: Fz - frontal, Cz - central, Oz - occipital, Td - right temporal and Ts - left temporal. During recording, skin resistance parameters are constantly monitored at the points of application of the electrodes, the values of which should not exceed 30 kOhm. Registration is carried out in the patient’s sitting position with open eyes continuously for a period of time in order to achieve steady-state SCP values with constant potentials reaching a “plateau”, usually within 10 minutes, while the electrode potential drift should not exceed 1-2 mV for this time. The values obtained at the end of the last minute of registration are taken into account.

Next, an analysis and comparison of the obtained values of SCP in all leads with reference values calculated statistically by the software of the device for the age and gender of this patient is carried out. The degree of compliance or mismatch with the normal SCP values in each registration zone is determined by comparing the obtained values with the values of the SCP intervals reflecting the level of metabolism and functioning of the cerebral cortex, are shown in Table 1.

Table 1

Ranges of the level of constant potentials of the brain and their interpretation

SCP ranges, mV Neurometabolism Assessment -70 to -40 mV Severe disturbance with a decrease in metabolic processes in the cerebral cortex. Tissue alkalosis (alkalization). Low brain activity. Adaptation opportunities are sharply reduced. -39 to 6 mV Moderate disturbance with a decrease in metabolic processes in the cerebral cortex. Unexpressed alkalosis of brain tissue (alkalization). Brain activity is moderately reduced. from 7 to 15 mV Norm. Optimal functioning of the cerebral cortex. 16 to 39 mV Moderate disturbance with increased metabolism in the cerebral cortex with increased anaerobic glycolysis and the release of lactate. Unexpressed acidosis (acidification of brain tissue). High functional activity of the brain. Tension adaptation mechanisms. 40 to 70 mV and higher Severe metabolic disturbance in the cerebral cortex with increased anaerobic glycolysis and the release of lactate. Acidosis (acidification), accompanied by oxidative stress in brain tissue. Adaptation opportunities are sharply reduced.

Then calculate the average level of constant potential Xsr by summing the values of the constant potential of all recorded points and dividing by their number of points (in this case, 5).

Next, an individual selection of colored lenses is carried out to minimize existing disturbances. In the room in which lenses are selected, the color of the walls and floor should be painted in mostly neutral colors: light gray, beige or gray-blue color without a pattern. There should not be anything in the room that could distract the patient's attention, it is also necessary to exclude extraneous sounds and smells. Lighting should be adjustable: lamps with a dimmer, windows with shutters or blackout curtains.

The selection of lenses is carried out as follows: the patient (sitting in a comfortable position, movements are minimal, eyes are open) is equipped with an empty spectacle frame on which the tested lenses are fixed in front of his eyes. Use lenses having absorption peaks at different wavelengths in the visible part of the spectrum (from 400 to 700 nm) and a degree of absorption of 10% or higher. The selection begins with transparent lenses without diopters, which the patient wears 3-5 minutes in order to get used to the frame and adapted to the selection procedure. Then they put on a patient’s frame with the first pair of tested lenses fixed on it and register the SCP during the time at which stable values of constant potentials are achieved, usually within 7-10 minutes. Values of SCP in the last minute are fixed. The patient is allowed to relax without a rim with his eyes closed in dim light for 5 minutes. After a period of rest, registration is repeated in the same way with each available lens sample, starting with the lightest lenses with a minimum percentage of light absorption.

For each sample, calculate the percentage change in the average level of constant potential (K) after wearing lenses compared to background values using the formula:

K = (Khsr _sample - Khsr _background / Khsr _sample ) * 100%

where: K is the percentage change in the average level of constant potential after wearing a test lens sample;

Hsr von - average level of constant potential (arithmetic average of the background SCP values for all 5 registration points obtained before wearing the lens sample);

XSR sample - the average level of constant potential (the arithmetic average of the SCP values for all 5 registration points obtained after wearing a lens sample).

When comparing the tested pairs of lenses, those lenses that are most suitable for the patient will be those that, as a result of test wear, have a maximum change in the average level of constant potential towards the reference values - when the average level of constant potentials shifts in at least one recording area, and the percentage change in the average value by 30% or more in the direction of approaching the reference values and establishing the soft starter in one or more of the recording areas in the range from 7 to 15 mV, the lenses are considered optimally selected and recommended for For color correction of disorders of the neurometabolism of the cerebral cortex. In the absence of significant changes or deterioration of indicators (deviation from normal values to a greater or lesser extent) - the lenses are not suitable for this patient.

If none of the lens options gives a pronounced effect, it is possible to apply several lenses with different spectral characteristics and the degree of absorption on each other to obtain the most optimal therapeutic combination.

The implementation of the method of color correction of disorders of the neurometabolism of the cerebral cortex can be carried out using visual stimuli. In this case, the background SCP values are recorded as described above, then, for example, a white A4 printed page with a noisy image with high contrast and a large number of small details (stripes, patterns) or with small text is placed in front of the patient’s eyes, for example printed in black on white paper, causing visual discomfort (Fig. 1). The patient is asked to continuously keep his eyes on the noisy image, re-register SCP to achieve stable values. The obtained values are compared with the background. It is necessary to use an image causing changes in the average soft starter by more than 8 mV from the reference value. The patient wears a frame with attached test lenses, continuing to look at the image, then re-register the SCP, after which the patient rests with his eyes closed for 5 minutes. A sample is taken with each lens sample. Those samples are selected, as a result of wearing which the maximum shift of the average SCP level towards optimal values (7-15 mV) occurred. In the absence of significant changes or deviation from normal values towards non-optimal - the lenses are not suitable for this patient.

Glasses with lenses are made, which are painted in a selected color combination taking into account the intensity of the shade (degree of light absorption). The patient wears glasses without taking off during the entire period of wakefulness every day to achieve the optimal therapeutic effect.

After a week of continuous patient wearing glasses with lenses, re-examination is carried out with the registration of SCP and calculation of K. With its value of 30% or more and finding the level of constant potential in the range from 7 to 15 mV for one or more areas of registration, the correction is considered effective. The patient is advised to continue to wear glasses constantly throughout the waking time. To track the dynamics, repeat the registration procedure for SCP after a month and six months of continuous wearing of glasses.

The experimental justification of the proposed method of color correction was carried out on 32 patients aged 2 to 60 years with impaired neuroenergetic metabolism of the cerebral cortex. The selection of subjects was based on complaints (photosensitivity, difficulty reading, writing, headaches) and an official diagnosis (autism, attention deficit hyperactivity disorder, dyslexia, delayed psycho-speech development). The neurometabolism of the cerebral cortex was evaluated in the frontal, central, occipital, right and left temporal zones. An individual selection of colored lenses and assessment of neurometabolism of the cerebral cortex after wearing selected lenses were carried out (table 2).

table 2

Average values of the level of constant potentials (for 32 patients)

Registration Channel Soft starter (mV) Significance of Differences
(compared to background) Background Values After wearing clear lenses without diopters After wearing a random lens combination After wearing specially selected lenses Reference 1 2 3 4 5 Fz 25.8 25.5 29.2 * 10.4 * 8.3 p <0.05 Cz 25.3 25.6 33.1 * 15.9 * 15.1 p <0.05 Oz 35.7 36.1 40.5 * 15.6 * 11.7 p <0.05 Td 23,4 23,2 25.3 12.0 * 11.8 p <0.05 Ts 18.7 17.9 20,0 15.6 10.6 p> 0.05 Khsr 25.8 25.6 29.6 * 14.1 * 11.5 p <0.05

At the first stage, the background AMR values were measured for all patients with calm wakefulness (1), then in lenses without tinting with zero optical power (2), in non-optimal lenses marked as unsuitable at the testing stage (3) and in optimal color lenses and density (4). In the case of wearing lenses without coatings, no marked shifts in SCP were observed, a slight decrease in activity was observed due to adaptation to the experimental conditions. In a non-optimal color combination, an increase in neurometabolism by an average of 4-5 mV was observed, which indicates an increase in the voltage of the adaptation mechanisms and the inclusion of backup glucose utilization pathways with the release of lactate and brain acidification. After wearing the optimal color combination, a decrease in the level of constant potentials towards standard values with a neutral acid-base balance (normalization of metabolism) was noted. At the same time, the new values of constant potentials were stable and persisted throughout the registration time (from 10 minutes to 1 hour).

The following are examples of the implementation of the method of color correction in patients with severe disorders of the neurometabolism of the cerebral cortex.

Polymeric lenses dyed with organic dyes were used with an absorption degree of 10% to 75% of light mainly in the blue-green part of the spectrum with a wavelength of 425-575 nm. Examples of absorption spectra of some lenses are shown in FIG. 6.

Example 1

Boy, 6 years old. Diagnosis: atypical autism. There is no speech. The behavior is chaotic, poorly focuses on the subject. According to the results of neuropsychological diagnostics, pronounced signs of visual and spatial perception impairment are observed, understanding of the body scheme, hypersensitivity to sounds, bright light and light touches are impaired, deep sensitivity is impaired.

The following indicators of the level of constant potentials were obtained on the background recording: Fz is 24.2 mV; Cz is 25.8 mV; Oz is 29.2 mV; Td is 24.5 mV; Ts is 18.5 mV; Xcp is 24.5 mV (Fig. 2). A comparison of the obtained indicators with the corresponding values of the SCP of the age normative scale was made and a moderate violation of the functional state of the cerebral cortex was revealed in the frontal, central, occipital, right temporal and left temporal regions. Diffuse hypoxia of these areas of the cerebral cortex was revealed. A shift in the values of acid-base balance towards acidification is observed. The greatest deviation from the normative values was found in the projection zone of the opto-parietal cortex.

The most suitable lenses were selected using the described method. The table shows the values of SCP when the child is wearing 3 lens samples: green with an absorption degree of 40%, pink with an absorption degree of 40% and yellow with an absorption degree of 40%. As can be seen from table 3, the indicators became closest to the reference after wearing sample 2: Fz is 22.4 mV; Cz is 22.1 mV; Oz is 18.5 mV; Td is 13.9 mV; Ts is 7.4 mV; Xcp is 16.9 mV (Fig. 3), while neurometabolism was normalized in two areas (right and left temporal), significantly closer to the reference level of activity in the occipital region.

Table 3

SCP values when wearing different lens samples

Registration Channel Soft starter (mV) Background Values Reference Sample 1 Sample 2 Sample 3

Fz 24,211 8,300 25,264 22,400 20,302 Cz 25,887 14,700 28,212 22,129 25,000 Oz 29,267 11,400 33,126 18,500 25,663 Td 24,493 11,400 23,026 13,948 16,374 Ts 18,486 10,600 20,624 7,421 18,260 Khsr 24,468 13,580 26,053 16,879 21,119

The percentage change in the average level of constant potentials for samples:

Sample 1 is equal to 6.4%;

Sample 2 is 31%;

Sample 3 is 13.7%.

After the patient wore sample 2, there was a change in the average SCP by 31% towards normal. Therefore, sample 2 is most suitable for this patient.

After continuous wearing of spectacle frames with selected lenses for 6 months, a significant improvement in patient behavior was noted, the attention retention time on the subject increased from 1-2 seconds to 10-15 seconds, the spatial field of perception expanded, the child began to examine his arms and legs, look into eyes of adults, hypersensitivity to sounds and light decreased, tantrums while in crowded places stopped, separate words and pointing gesture appeared, understanding of conversational speech improved. Neuroenergy mapping data indicate a normalization of metabolic processes in the frontal, occipital, right and left temporal regions of the cerebral cortex, a moderate change in the central zone (SCP indicators: Fz is 10.2 mV; Cz is 18.0 mV; Oz is 10.5 mV ; Td is 14.3 mV; Ts is 11.5 mV; Xcp is 12.9 mV).

Example 2

Woman, 50 years old. Photosensitivity, migraine, blurred vision, problems with orientation in space, frequent dizziness, difficulty reading and concentration on the text, especially when working on a computer.

The following values of constant potentials were obtained on the background recording: Fz is 22.3 mV; Cz is 33.6 mV; Oz is 38.6 mV; Td is 23.2 mV; Ts is 21.2 mV; Xcp is 27.8 mV. A moderate violation of neurometabolism was revealed in the frontal, central, occipital, left and right temporal regions. The selection of lenses was carried out by considering a noisy image of a panda (Fig. 1). When viewing a noisy image for 3 minutes, the following indicators were recorded: Fz is 26.6 mV; Cz is 49.3 mV; Oz is 61.8 mV; Td is 29.6 mV; Ts is 25.4 mV; Xcp is 38.5 mV (Fig. 4). After viewing the image in brown lenses with a degree of absorption of 20%, the maximum, in comparison with other options, decrease in the level of constant potentials in the frontal, central, occipital and left temporal regions was recorded: Fz is 16.4 mV; Cz is 28.1 mV; Oz is 42.9 mV; Td is 38.5 mV; Ts is 24.9 mV; Xcp is 30.1 mV (Fig. 5). This option was recommended to the patient for wearing in spectacle frames. After wearing glasses for a week, the patient noted a significant improvement in well-being, increased efficiency, concentration when working with text, the disappearance of severe headaches and photophobia.

For comparison, Table 4 shows the SCP values recorded after the patient examined the image in non-optimal lenses rejected at the selection stage (orange lenses with an absorption rate of 20%).

Table 4

SCP values obtained using visual stimuli

when wearing different lenses

Registration Channel Soft starter (mV) Background Values Viewing images without lenses Viewing images in brown lenses Viewing images in orange lenses Fz 22,302 26,583 16,380 29,320 Cz 33,600 49,332 28,114 42,630 Oz 38,651 61,828 42,919 58,321 Td 23,200 29,572 38,515 30,750 Ts 21,254 25,431 24,920 26,645 Khsr 27,801 38,549 30,169 37,533

The proposed method solves the problem of improving the correction of metabolic activity of the cerebral cortex in various conditions - dyslexia, dysgraphia, visual agnosia, scotopic sensitivity syndrome, autism, mental retardation and other disorders caused by brain dysfunctions and helps to improve the productivity and quality of life of the general population. The method has an advantage over the known ones, which consists in the possibility of an objective assessment of the effect of wearing optimally selected colored lenses with varying degrees of light absorption on the neurometabolism of the cortical parts of the brain, including in individuals with severe impairment of behavior, intelligence and speech.

Claims (5)

1. A method for color correction of neurometabolism in the cerebral cortex, including the patient wearing individually selected colored spectacle lenses with varying degrees of light absorption, characterized in that prior to the selection of lenses, the patient is monitored for the background level of constant brain potential (SCP) in the frontal, central, occipital, right and left temporal areas; the selection of lenses is carried out by wearing the patient’s frames with pairs of test lenses alternately fixed on it with continuous recording of brain SCP in the frontal, central, occipital, right and left temporal regions for each pair of lenses under investigation over time until stable values of constant potentials with drift reach more than 2 mV in 10 minutes, with fixing the results of the SCP level at the last minute of measurements and rest after checking each pair of lenses; determine the arithmetic mean value for the background SCP for all 5 registration areas (Xsr background, mV) and the arithmetic average for the SCP after wearing a rim with each pair of lenses for all 5 registration areas (Xsr sample, mV), then calculate the percentage change in the average SCP ( K,%) according to the formula K = (Xsr sample - Khsr background / Khsr sample) × 100%, and with a value of K at least in one recording region of 30% or more and establishing an SCP in one or more recording regions ranging from 7 to 15 mV, the lenses are considered finally matched and recommended for wearing while the patient is awake, followed by periodic control measurements of the SCP - a week, six months and a year after wearing lenses, with the implementation of additional corrective selection of lenses. 2. A method for color correction of disorders of the neurometabolism of the cerebral cortex according to claim 1, characterized in that the lenses obtained by applying several differently colored lenses with different degrees of light absorption are recommended for continuous use. 3. A method for color correction of disorders of the neurometabolism of the cerebral cortex according to claim 1, characterized in that lenses are recommended for continuous use, the selection of which is carried out by focusing the patient’s gaze on visual stimuli, which are a noisy image with high contrast and a lot of small details or text, printed on a sheet of white paper in small black print, using visual stimuli that cause changes in the average SCP by more than 8 mV from the reference value.

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