RU2504383C1 - Method of treating acute postpartum endometritis in cows - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to veterinary gynaecology, particularly to treating acute postpartum endometritis in cows, and can find application in dairy farms and complexes. A method of treating acute postpartum endometritis in cows involves the intrauterine administration of an antimicrobial agent with the antimicrobial agent being presented by an emulsion consisting of sterile sunflower oil, the preparation ASD-3 and oxytetracycline, prepared of sterile sunflower oil 1000 ml added with the preparation ASD-3 35 ml and oxytetracycline-200 30 ml; the prepared suspension is kept at a room temperature for one day; before the administration, the emulsion is heated to temperature 38-39°C and administered in a dose of 110-150 ml per one animal 2-3 times every 48 hours.

EFFECT: method enables the higher therapeutic effectiveness in acute postpartum endometritis in cows by 25-30%, makes the treatment 8 days shorter.

Description

The invention relates to the field of veterinary gynecology, in particular to the treatment of acute postpartum endometritis in cows, and may find application in dairy farms and complexes.

There is a method of treating endometritis in cows, including the intrauterine administration of iodismuthsulfatisole, furacilin is additionally introduced into iodismuthsulfatisole at a rate of 1: 100, the mixture is administered in a dose of 100 g per animal with an interval of 22-24 hours, 3-6 times, and at the same time additional subcutaneous the introduction of 20-25 ml of a tissue preparation from the spleen three times with an interval of 3 days and intramuscular administration of a 0.5% solution of proserin in a dose of 1.5-2 ml for three consecutive days [Patent No. 2030180 SU, A61K 33/00].

The disadvantages of this method: a decrease in therapeutic efficacy in endometritis in cows, due to the emergence of microbial resistance to it, a complex therapy technique.

The closest in technical essence to the proposed method is a method of treating endometritis in cows, including the introduction into the uterus of an antimicrobial agent with an interval of 48 hours - emulsions of iodismuthsulfamide in a dose of 50-100 ml per animal on the first, third, fifth, seventh days. [Grigoryeva T.E. Treatment and prevention of endometritis in cows. - M .: Rosagropromizdat, 1998 - S.46, 51].

The disadvantages of this method is the low therapeutic efficacy of the treatment, the duration of treatment.

The technical result of the invention is to increase the therapeutic efficacy of treatment, reducing treatment time.

The technical result is achieved by the fact that a method of treating acute postpartum endometritis in cows, including the introduction of an antimicrobial agent into the uterus, uses an emulsion as a antimicrobial agent, consisting of sterile sunflower oil, ASD-3 and oxytetracycline, for which 1000 ml of sterile sunflower oil is taken add 35 ml of the drug ASD-3 and 30 ml of oxytetracycline-200, the resulting emulsion is kept at room temperature for a day, before the introduction of the emulsion is heated, before eratury 38-39 ° C and injected at a dose of 110-150 ml per animal 2-3 times every 48 hours.

Introduction to the proposed method for the treatment of acute postpartum endometritis in cows, the drug ASD-3, which has antiseptic and stimulating properties, increases the therapeutic effectiveness of the treatment.

The use in the proposed method for the treatment of acute postpartum endometritis in cows of oxytetracycline-200 with a wide antimicrobial spectrum of action, especially for gram-positive aerobic bacteria - Staphylococcus spp., Streptococcus spp .; gram-negative bacteria - Neisseria gonorrhoeae, Bordetella pertussis, Enterobacter spp., Escherichia coli, Klebsiella spp., Salmonella spp., Shigella spp .; anaerobic bacteria - Clostridium spp .; in relation to Rickettsia spp., Chlamydia spp., Mycoplasma spp., Spirochaetaceae, increases the therapeutic effectiveness of the treatment.

The use in the proposed method for the treatment of acute postpartum endometritis in cows of sterile sunflower oil provides softening of the walls of the uterus and the birth canal, which contributes to the absorption of the drug ASD-3 and oxytetracycline, increases the therapeutic effectiveness of the treatment

Using an emulsion consisting of sterile sunflower oil, an ASD-3 preparation and oxytetracycline for the preparation of which 1000 ml of sterile sunflower oil is taken, add 35 ml of an ASD-3 preparation and 30 ml of oxytetracycline-200, the resulting emulsion is kept at room temperature for a day before the introduction of the emulsion is heated to a temperature of 38-39 ° C and administered at a dose of 110-150 ml per animal 2-3 times with an interval of 48 hours reduces the treatment time for acute postpartum endometritis in cows.

A method for the treatment of acute postpartum endometritis in cows is as follows. An antimicrobial preparation, an emulsion, is prepared. To do this, take 1000 ml of sterile sunflower oil, add 35 ml of the drug ASD-3 and 30 ml of oxytetracycline-200. The resulting emulsion is kept at room temperature for a day. Before introducing into the uterus of the cow, the emulsion is heated, for example, in a water bath to a temperature of 38-39 ° C. The emulsion is collected, for example, in a Janet syringe and injected into the uterine cavity using a single polystyrene pipette at a dose of 110-150 ml per animal. The repeated procedure for the introduction of the emulsion is carried out after 48 hours. The dose of the emulsion and the frequency of administration depends on the degree of acute postpartum endometritis.

Testing of the proposed method for the treatment of acute postpartum endometritis was carried out in a pilot farm. According to the principle of analogues: taking into account age, weight, lactation, 2 groups of cows were selected, 43 heads each with acute postpartum endometritis. The treatment regimens for each of the groups were compiled. In the treatment of acute postpartum endometritis in cows in the experimental group, an emulsion of sterile sunflower oil, ASD-3, oxytetracycline was used, for the preparation of which 1000 ml of sterile sunflower oil was taken, 35 ml of ASD-3 and 30 ml of oxytetracycline-200 were added, the emulsion obtained kept at room temperature for a day, before the introduction of the emulsion is heated to a temperature of 38-39 ° C. In the control group, an emulsion of iodobismuthsulfamide was used. The cows of the experimental group were injected with an emulsion of sterile sunflower oil, the drug ASD-3, oxytetracycline at a dose of 110-150 ml intrauterine with an interval of 48 hours until the complete disappearance of pathological discharge from the uterus. The cows of the control group were injected intrauterine emulsion of iodismuthsulfamide in a dose of 50-100 ml with an interval of 48 hours until the complete disappearance of pathological discharge from the uterus.

Health monitoring of experimental cows was carried out by methods generally accepted in clinical practice. Monitoring the effectiveness of treatment was carried out using clinical observations - transrectal studies and ultrasound. During treatment, the condition of the animals was assessed as satisfactory. In the course of the experiment, positive dynamics of the course of the disease was observed.

In the experimental group, after 6 days of treatment, recovery was observed in 43 cows, in the control group after 14 days of treatment, recovery was noted in 30 cows. The therapeutic efficacy in the experimental group in was 100%, in the control group - 70%.

Due to the use of an emulsion of sterile sunflower oil, the drug ASD-3 and oxytetracycline in a dose of 100-150 ml per animal 2-3 times with an interval of 48 hours, the therapeutic effectiveness of the treatment of acute postpartum endometritis is increased by 25-30%, the treatment period for acute postpartum is reduced endometritis in cows for 8 days.

Acute postpartum endometritis in cows causes cow infertility and barrenness. Using the proposed method for the treatment of acute postpartum endometritis in cows significantly reduces the damage caused to livestock farms by infertility and barrenness of cows.

The proposed method of treatment has been tested in laboratory conditions at the Department of Diagnostics of Internal Noncommunicable Diseases and Pharmacology, Surgery and Obstetrics, Veterinary Department of FSBEI HPE OmGAU im. P.A. Stolypin, as well as in a pilot farm.

Claims (1)

A method of treating acute postpartum endometritis in cows, comprising administering an antimicrobial agent into the uterus, characterized in that an emulsion consisting of sterile sunflower oil, ASD-3 preparation and oxytetracycline is used as an antimicrobial agent, for which 1000 ml of sterile sunflower oil is taken, added 35 ml of the drug ASD-3 and 30 ml of oxytetracycline-200, the resulting emulsion is kept at room temperature for a day, before the introduction of the emulsion is heated to a temperature of 38-39 ° C and introduced at a dose of 110-150 ml per animal 2-3 times with an interval of 48 hours