RU2337608C1 - Diagnostic complex for measurement of medicobiological parameters of skin and mucosas in vivo - Google Patents

Abstract

FIELD: medical equipment.

SUBSTANCE: diagnostic complex for measurement of medicobiological parametres of a skin and mucosas in vivo contains block of sources of primary optical radiation with different lengths of radiation waves, system of transportation of primary and secondary radiation to biological tissue and back, executed in the form of a harness of optical fibers with the branched out instrument and uniform working part, optoelectronic system of registration of the secondary optical radiation, containing photodetectors with optical filters, polychromator with a diffraction latitude and the device of the collecting and translation of data in the block of diagnostics results processing. The block of sources of radiation is supplied with the synchronizer with the built in generator of basic signals, the binary counter of impulses and the converter of a binary code in a positional one, and the optoelectronic system of registration of the secondary radiation, consisting of three photodetectors, is supplied with a differential formation block of Doppler signal. The polychromator it is supplied with the input lensed achromatic collimator, and its diffraction latitude is executed concave. The system of transportation of optical radiation is executed from 9 optical fibers, 8 of them are placed equally spaced in a working part on a circle around the central fiber. Inputs of sources of radiation are connected to the synchronizer outputs with a position code, its output of the binary code is bridged to an input of the device of data collecting and translation of optoelectronic system of registration of secondary optical radiation, sources of radiation are connected to the optical fibers placed on a circle, and one of fibers is bridged to constantly powered on source of radiation, on two interfacing to it from each side of the fiber are bridged to sources of radiation joining serially, each of fibers adjoining the last from both parties are connected to two photodetectors which exits are bridged with the differential formation block a Doppler signal, and an optical fiber, opposite to the fiber bridged to constantly included source of radiation, is bridged to the third photodetector, the central fiber is connected to the achromatic collimator of the polychromator.

EFFECT: invention allows increasing noise stability of a diagnostic complex and multitasking capability diagnostic system in a real time regimen.

5 cl, 4 dwg

Description

The invention relates to the field of medicine and medical instrumentation, namely to laser medical diagnostic equipment that implements complex non-invasive methods (in vivo, in situ), non-destructive, intravital diagnostics, control and / or monitoring of the functional and / or pathophysiological state of human tissues based on methods laser spectral analysis, spectrophotometry of scattering and absorption, laser Doppler flowmetry, etc.

A known method and device for biophotometric monitoring of the state of affected biological tissues (USSR copyright certificate 1545346, 1984; USSR copyright certificate 1481938, 1985).

A known method and device for determining the speed of capillary blood flow using the Doppler effect, as well as methods for assessing the state of biological tissues based on them (US patent 4596254, 1986, RF patent 2140199.1999).

A known method and device for non-invasive fluorescence diagnosis of malignant neoplasms in human tissues (RF patent 2012243, 1994, US patent 5647368, 1997).

A known method and device for non-invasively determining the percentage of oxyhemoglobin in human blood (US patent 4714341, 1987), as well as a device for determining together the level of volumetric blood filling of soft tissues and the percentage of oxyhemoglobin in the blood (RF patent 2234853, 2002) on based on optical absorption spectroscopy data.

However, all of the above methods and devices have many disadvantages. The main and significant drawback of all these methods and devices is the receipt of separate fragmentary data based on one of the selected in vivo diagnostic methods for one of the analyzed physical phenomena (fluorescence, optical absorption, Doppler effect, etc.), without taking into account the influence always present at the interaction of optical radiation and biological tissue and other physical phenomena and factors, which significantly reduces the efficiency, reliability and information content of the diagnostics from the point of view of practical th medicine.

A comprehensive diagnostic system is known for the optical analysis of living biological tissues (patent EP 1340452, class AB 5/00, 2003), which combines at least 3 separate diagnostic methods (fluorescence diagnostics, Doppler flowmetry, optical oximetry, etc. .) and analyzes the data of each individual method to form the final diagnostic result.

The disadvantage of this diagnostic system is the simplified design solution, which consists in a simple summation of individual diagnostic devices, which allows the formation of a diagnostic result only in the form of the conclusion "positive diagnostic result" (pathology is detected) or "negative diagnostic result" (no pathology), if at least two of the diagnostic methods provide the basis for such a conclusion. Those. in this case, the diagnosis is based on the simplified yes-no principle, which does not allow the doctor to obtain the necessary medical and biological information on the functional and pathophysiological state of the biological tissue, which these diagnostic methods can potentially give (parameters of blood microcirculation, percentage of bilirubin or oxyhemoglobin in the blood, the presence of tissue enzymes of the porphyrin class, flavin respiratory enzymes, etc.).

Closest to the proposed is a diagnostic complex for measuring biomedical parameters of the skin and mucous membranes in vivo, containing a block of primary optical radiation sources with different radiation wavelengths, a system for transporting primary and secondary optical radiation to biological tissue and vice versa, made in the form of an optical tow fibers with a branched instrument and a single working part, the ends of the fibers of which are placed in one plane, the optoelectronic registration system is secondary optical radiation containing photodetectors with optical filters, a polychromator with a diffraction grating and a device for collecting and transmitting data to the processing unit for diagnostic results (RF patent No. 2234242, class A61B 5/05, 2003).

Using this device, several diagnostic methods are simultaneously implemented (spectroscopic method, photometric method, Doppler spectrum analysis, etc.).

However, this diagnostic system, despite its significant diagnostic capabilities, was not devoid of a number of significant drawbacks according to the results of its detailed design study, manufacture and trial operation in the clinic.

Among the identified main disadvantages, the following can be noted.

- The presence in the block of radiation sources of a special radiation mixer, which ensures the mixing and input of radiation from different sources into one single optical fiber (lens) of the radiation transportation system to biological tissue, which, in turn, is designed to form one and the same for all used radiation wavelengths the area of illumination on the surface of the biological tissue. Such a radiation mixer complicates and increases the cost of the design, and its failure immediately leads to a complete loss of operability of the entire diagnostic system as a whole.

- The necessary presence in the signal processing system of two or more identical optoelectronic units, which are very complex and expensive to manufacture, configure and operate. In practice, it turns out to be very difficult to achieve the same technical characteristics even for two such blocks due to the technological variation in the technical characteristics of the individual component parts of these blocks, which leads to uneven characteristics in general and, accordingly, to errors in the final diagnostic result.

- The necessary presence of "n" high-speed photodetectors in one of the spectral optical units of the signal processing system, the total number of "n" equal to the total number of wavelengths of the radiation sources.

- The mandatory presence of a complex and multi-stage computational algorithm in the processing unit of the diagnostic results, which, when studying typical dynamic processes, for example, blood microcirculation (microcirculation rhythms), realized in biological tissues in the frequency range 0-20 Hz and recorded by the Doppler method, does not allow all calculations in real time even on modern high-speed 2-core personal computers. This leads to the fact that the diagnostic result appears with a time delay, which does not allow the doctor to effectively carry out any functional studies and to observe the dynamics of the patient’s indicators during the functional load tests. In addition, the additional time required for processing the results, in addition to the time of the actual diagnostic procedure, reduces the overall throughput of the diagnostic system as a whole and reduces its effectiveness in practical healthcare.

All this together makes the diagnostic system ineffective in practice, expensive and complicated in technical implementation and operation. In addition, it leads to the appearance of additional instrumental diagnostic errors, and the diagnostic process based on this diagnostic system is deprived of one of its important consumer qualities - the real time scale for obtaining the final diagnostic result.

The task posed by the authors is aimed at eliminating these shortcomings and creating a simpler, cheaper and more effective in practice multifunctional laser medical diagnostic system suitable for solving in vivo practical real-time diagnostic problems.

This problem is solved in that in the diagnostic complex for measuring the biomedical parameters of the skin and mucous membranes in vivo, containing a block of primary optical radiation sources with different radiation wavelengths, a system for transporting primary and secondary optical radiation to biological tissue and vice versa, made in in the form of a bundle of optical fibers with a branched instrument and a single working part, an optoelectronic system for recording secondary optical radiation containing photodetectors ki with optical filters, a polychromator with a diffraction grating and a device for collecting and transmitting data to the processing unit for the diagnosis results, it is proposed that the block of optical radiation sources be equipped with a synchronizer with a built-in reference signal generator, a binary pulse counter and a binary code to position converter, and an optical-electronic registration system secondary radiation, consisting of three photodetectors, to provide a differential block for the formation of the Doppler signal, polychromator - input lens m achromatic collimator and perform with a concave diffraction grating. In this case, the optical radiation transportation system should be implemented with 9 optical fibers, the ends of the working part 8 of which should be placed at an equal distance from each other in a circle around the central fiber. The inputs of the radiation sources are connected to the outputs of the synchronizer with a positional code, the binary code of which is connected to the input of the data acquisition and transmission device of the optoelectronic system for recording secondary optical radiation, and the radiation sources are connected to optical fibers placed on a circle. Moreover, one of the fibers of the radiation transportation system is connected to a permanently switched on source of radiation, two fibers adjacent to it on each side are connected to radiation sources that are switched on alternately, each of the fibers adjacent to the last on both sides is connected to two photodetectors, the outputs of which are connected to a difference block the formation of the Doppler signal, and an optical fiber diametrically opposite to the fiber connected to a continuously switched on source of radiation, connected to the third photoconductor iemnikom, central achromatic fiber collimator connected to the polychromator.

In addition, it was proposed that the filters of two photodetectors, the outputs of which are connected to a difference block for generating a Doppler signal, transmit radiation only at the wavelength of a radiation source operating continuously, and for the third photodetector, all other wavelengths of other radiation sources of the source block.

The implementation of a difference block of the Doppler signal generating circuit is proposed, in which it contains 2 AC signal filters, two voltage dividers and a difference circuit of two signals, while the outputs of the photodetectors connected to the difference Doppler signal generating block are connected to the corresponding variable signal filter and X "the input of the voltage divider, to the other" Y "input of which the output of the same AC signal filter is connected, and the outputs of the dividers, each of which forms the ratio Z = Y / X, connected further to the inputs of the circuit for generating the difference of two signals.

It is proposed to connect the optical fiber of the radiation transportation system with a radiation source operating continuously, as well as to perform this mode single-mode.

In addition, it is proposed that the optical fibers of the radiation transportation system be performed with a metallized coating 1-100 μm thick sprayed onto their shell.

Figure 1 shows a diagram of a multifunctional diagnostic complex, figure 2 is a diagram of the synchronizer of the operation of radiation sources; figure 3 - layout of the fibers in the working part of the radiation transport system; figure 4 is an electronic circuit of a difference block for the formation of the Doppler signal.

The diagnostic complex (Fig. 1) consists of a block of sources of primary (probe) optical radiation 1, a transportation system 2 of primary and secondary optical radiation to biological tissue 3 and vice versa, an optoelectronic system for recording secondary optical radiation 4, and a diagnostic processing unit 5.

The block of primary optical radiation sources 1 contains a synchronizer for the operation of radiation sources 6, separate ones, for example, laser radiation sources for different wavelengths 7.1, 7.2 ... 7.n, where 2 <n <6, as well as standard optical focusing lenses 8.1, 8.2 ... 8.n (2 <n <6) for each source with optical connectors for connecting an external optical fiber to them. In this case, the synchronizer 6 of the operation of the radiation sources is made according to the scheme (Fig. 2) with a built-in standard internal reference signal generator 9 having outputs of a constant signal 9a and a reference signal frequency> 20 Hz 9b, a binary counter 10 with a counting coefficient n + 1, where n - the number of individual radiation sources in the source block 1, as well as a binary to positional converter 11. Functionally, the synchronizer 6 is designed to turn on the radiation sources in the mixed radiation mode so that one of the radiation sources m input connected to the positional output of the synchronizer, connected to the output of the constant signal 9a of the signal generator 9, is constantly working, and the remaining radiation sources work alternately, as well as to generate a binary code of the number of the radiation source working at each moment of time and transmit it further to the optical electronic registration system for secondary optical radiation 4. For this, the synchronizer 6 has a corresponding additional output of the binary code connected to the output of the binary signals counter.

The choice of specific working wavelengths of radiation is determined by the task of spectrophotometry to detect the presence or absence in the biological tissue of various optical light absorbers (melanin in the skin, hydroxy- and deoxyhemoglobin in the blood, etc.). In the General case, to determine the N optically active absorbers within the tissue, as a rule, N + 1 spectral optical range is required. In addition, at least one spectral range (one wavelength) is required to implement the laser Doppler flowmetry method and a minimum of 3 wavelengths is necessary for recording the most important fluorophores of biological tissues by their characteristic fluorescence (phosphorescence) spectra by laser fluorescence spectroscopy (pyridine nucleotides, flavins and porphyrins ) Since part of the radiation wavelengths (spectral ranges) can be used simultaneously for two or more problems in the proposed version of the diagnostic complex (together, for example, for spectrophotometry and fluorescence spectroscopy), the minimum number of emitters can be considered - n = 3, but quite sufficient for most practical medical applications n = 5.

For example, the block of radiation sources in the proposed design of the diagnostic complex may contain n = 3 laser radiation sources at wavelengths of 350 nm, 532 nm and 632 nm, with a constantly working source at 632 nm, which allows the implementation of laser Doppler flowmetry, fluorescence diagnostics and optical tissue oximetry (determination of the percentage of blood oxyhemoglobin fraction). An extended version with n = 5 and wavelengths of radiation sources of 350 nm, 405 nm, 532 nm, 632 nm and 805 nm, with a constantly working source at 805 nm, allows one to additionally determine the presence of lipofuscin, melanin in the tissues, the total volumetric blood supply of tissues, and t .d. As an additional option that improves the noise immunity and performance of the structure as a whole, it is proposed to use a high-quality single-mode laser as a radiation source operating continuously.

The transportation system 2 of the primary and secondary optical radiation to the biological tissue and vice versa is made in the form of a bundle of nine separate optical fibers with a branched instrument part 2a and a single working part 2b facing the biological tissue under study 3. Moreover, at the end of the instrument part, each individual fiber isolated from the common harness, connected using standard optical connectors, for example, type "SMA-705" or "FC", to the inputs and outputs of the individual elements of blocks 1 and 4 of the diagnostic complex, as shown in ig.1, including the outputs of the individual light sources that distinguishes the design of this unit from the prototype, and eliminates the need for placement in a special source of radiation emission unit of the mixer. And at the end of the working part, facing the biological tissue, the optical fibers with their ends are placed and fixed in a single bundle in the same plane as shown in Fig.3. 8 fibers 2.1 ... 2.8 are placed at an equal distance from each other around a circle with a diameter of 1-2 mm in a certain order, around one central fiber 2.9. Two adjacent fibers 2.1, 2.2 and 2.4, 2.5, are placed on each side of fiber 2.3, fibers 2.6, 2.8 are adjacent to the latter on both sides, fiber 2.7 is placed on a circle diametrically opposite to fiber 2.3. Moreover, fiber 2.3 is connected to a constantly switched on source of radiation, fibers 2.1, 2.2 and 2.4, 2.5 are connected to radiation sources that are switched on alternately 7.2 ... 7.n.

Fibers 2.1 ... 2.5 realize the delivery of primary radiation to biological tissue. Fibers 2.6 ... 2.8 and 2.9 are designed to transport secondary optical radiation from biological tissue to the secondary radiation registration system 4.

This arrangement and functional purpose of the fibers makes it possible to have both the same, for example 2.3-2.6 and 2.3-2.8, and different, for example 2.3-2.7 and 2.5-2.7, distances between the illumination area of biological tissue with primary optical radiation and the place of collection of secondary optical radiation from it that allows more accurately and in real time to further implement the method of registration and separation of Doppler signals, and also leaves the possibility to fully implement all the calculation algorithms for other diagnostic methods and channels.

As an additional option that improves the noise immunity and performance of the structure as a whole, it is proposed to use single-mode optical fiber as an optical fiber 2.3, transmitting radiation from a radiation source operating continuously.

It is also proposed to use optical fibers with a thin metallized coating sprayed on their shell with a thickness of 1-100 μm, which excludes optical cross-illumination in the system, as an additional option that improves the noise immunity of the radiation transportation system.

The optoelectronic registration system for secondary optical radiation 4 contains a polychromator 12, made on the basis of a concave diffraction grating (combining the functions of a concave spherical mirror and a diffraction grating), which in this connection is additionally equipped with an input lens achromatic collimator 13 for pairing the optical fiber with an optical polychromator circuit, an amplifier-driver of signals from a polychromator 14, which provides the formation of signals in the form of a functional dependent ty “amplitude - wavelength” for laser optical spectroscopy and fluorescence diagnostic techniques, three separate photodetectors 15.1-15.3, for example three silicon photodiodes with appropriate filters and optical connectors 16.1-16.3 for connecting fibers from the secondary optical radiation transportation system 2 from biological tissue, amplifier-driver of signals of the spectrophotometric diagnostic method 17, a differential block for generating a Doppler signal 18 and a device for collecting and transmitting data 19 to the processing unit diagnostic diagnostics 5. In this case, an optical fiber located in the working part of the transportation system 2 2.7 is connected to the input of a photodetector connected to an amplifier-signal generator of a spectrophotometric diagnostic method 17, and fibers 2.8 and 2 are connected to the inputs of two photodetectors connected to a difference unit 18 (figure 3), and to the input of the achromatic collimator polychromator 13 is an optical fiber located in the center of the tow 2.9. The data collection and transmission device 19 is a standard microprocessor device that allows you to collect and accumulate analog electrical data from blocks 14, 17, 18, convert them to digital form, generate code packages with data binding from the synchronizer 6 of the radiation source block, etc. ., as well as transmit them in the format of computer signals via standard interface buses (COM port, USB port, etc.) to the diagnostic processing unit 5.

The block for processing the results of diagnostics 5 is a standard personal computer or any specialized computer with appropriate software.

As an embodiment of the construction of the differential block for generating the Doppler signal 18, an electronic circuit is used (Fig. 4), containing 2 filters of an alternating signal 20.1 and 20.2, which select signals in the band of the Doppler frequency shift on moving blood cells (100 Hz - 20 kHz), two dividers voltage 21.1 and 21.2 and the actual circuit for generating the difference of two signals 22. Moreover, the output of each of the two photodetectors 15.2 and 15.3 connected to its input, inside it is connected first to the corresponding filter of the alternating signal 20 and one to the "X" input of the voltage divider 21, to the other "Y" input of which the output of the same AC signal filter is connected, and the outputs of the dividers, each of which forms the ratio Z = Y / X, are connected already further to the inputs of the circuit for generating the difference of two signals 22. This allows, in contrast to the prototype, to assign some of the functions for generating and processing the most complex Doppler signal to the device hardware, substantially freeing the computing resources of block 5 for higher-level data processing, i.e. this constructive solution allows you to save time on calculations, increases the speed of the entire system as a whole and gives it, unlike the prototype, the properties of a real-time system.

As an additional embodiment of the optoelectronic system for recording secondary optical radiation 4, which improves the noise immunity and operational performance of the structure as a whole, a design option is proposed when such optical filters 16.1- are installed in front of each of the 3 separate photodetectors of the optoelectronic system for recording secondary optical radiation. 16.3 with optical connectors that transmit radiation for two photodetectors 15.2-15.3 connected to a differential block 18 forming dopple signal, only at the wavelength of the radiation source operating continuously, and for the third photodetector 15.1, all other wavelengths, other radiation sources of the source block 1, except for the wavelength of the source operating continuously.

The diagnostic complex in this configuration as a whole works as follows.

The synchronizer 6 turns on the sources 7 in the mode when one source works continuously, and the rest - alternately, and generates a binary code of the radiation source working at each moment of time, transmitting it to the data collection and transmission device 19. The radiation of the sources through the transportation system 2 goes to the biological tissue 3, and the secondary radiation from biological tissue into the optoelectronic system for recording secondary optical radiation 4.

To generate data for the spectroscopy method and laser fluorescence diagnostics, part of the recorded secondary radiation enters through an achromatic collimator 13, which forms a parallel light beam from optical fiber 2.9, into a polychromator 12, where it is decomposed into a spectrum by a concave diffraction grating and the whole spectrum is then recorded in a standard way using a photodetector array based, for example, CCD structures. The electrical signals from the CCD photodetector are then amplified by block 14, filtered, and transmitted to the device 19 with reference to the registered radiation power density to the light wavelength in the range 300-1000 nm.

The data for the absorption spectrophotometry and scattering spectrophotometry methods are generated using an optical fiber 2.7, a photodetector 15.1 and block 17. Moreover, for three different radiation sources, with different wavelengths of the primary (probing) radiation connected to the optical fibers 2.1-2.3 (or 2.3- 2.5), the registration of secondary optical radiation from biological tissue by optical fiber 2.7 will occur at different distances from the point of illumination of biological tissue, which fully allows the hardware to implement the spectrophotometry method in part EFINITIONS all scattering and absorption properties of the biological tissue, but simpler hardware than incorporated in the prototype, as well as all the computing algorithms built into the prototype for this method. Moreover, the sequential operation of all radiation sources, with the exception of one, with one empty cycle, when all of them turn off, allows for the registration of secondary optical radiation from biological tissue in this method to use only one photodetector.

The signal of the Doppler spectrum (laser Doppler flowmetry method) in the proposed design of the diagnostic complex is continuously and hardware-recorded (generated) during continuous operation of one of the radiation sources using receiving optical fibers 2.6 and 2.8, photodetectors 15.2-15.3 and difference block 18. The same distance of the receiving fibers 2.6 and 2.8 from an optical fiber 2.3 with primary probing radiation make it possible to directly distinguish non-synchronous oscillations in signals caused by using light on moving elements of the medium (blood cells) and Doppler shift of the primary radiation spectrum. The final collection, generation and conversion of signals with reference to the wavelengths of the working radiation sources in the form of standard computer signals is carried out in device 19 of system 4. Using modern standard microprocessor controllers as device 19 allows you to generate almost any computer signal, including for the exchange protocol data through the standard USB port, which further increases the speed and throughput of the entire system.

The final processing of data in the form of computer signals occurs in the processing unit for diagnostic results 5 using known programs and algorithms similar to those described in patents for analogues of the invention (for example, patent RU 2234853) or in the patent for the prototype. These programs and algorithms are generally known and are not the subject of this invention.

This ideology and design of the diagnostic complex allows you to create a multifunctional in vivo real-time diagnostic system, with significantly simpler hardware and much more noise immunity than is done in the prototype device. This design, as described above, eliminates all the design flaws of the prototype, more reliable in operation, has higher accuracy in diagnosis and is suitable for solving practical problems of medicine.

Claims (5)

1. Diagnostic complex for measuring biomedical parameters of the skin and mucous membranes in vivo, containing a block of primary optical radiation sources with different radiation wavelengths, a system for transporting primary and secondary radiation to biological tissue and vice versa, made in the form of a bundle of optical fibers with branched instrument and a single working part, an optoelectronic system for recording secondary optical radiation, containing photodetectors with optical filters, polychromatic p with a diffraction grating and a device for collecting and transmitting data to the diagnostic results processing unit, characterized in that the radiation source unit is equipped with a synchronizer with an integrated reference signal generator, a binary pulse counter and a binary to position converter, and an optical-electronic secondary radiation registration system, consisting of three photodetectors, equipped with a differential block for the formation of the Doppler signal, the polychromator is equipped with an input lens achromatic collimator, and its the diffraction grating is concave, the optical radiation transportation system is made of nine optical fibers, eight of which are placed at an equal distance from each other in the working part around the central fiber, with the inputs of the radiation sources connected to the outputs of the synchronizer with a position code, binary code output which is connected to the input of the data acquisition and transmission device of the optoelectronic system for recording secondary optical radiation, the radiation sources are connected to fibers placed on a circle, one of the fibers being connected to a permanently switched on radiation source, two fibers adjacent to it on each side connected to radiation sources switched on alternately, each of the fibers adjacent to the latter on both sides are connected to two photodetectors, the outputs of which are connected to a difference block for the formation of a Doppler signal, and an optical fiber diametrically opposite to a fiber connected to a continuously switched on radiation source is connected to a third By using a photodetector, the central fiber is connected to the achromatic collimator of a polychromator. 2. The diagnostic complex according to claim 1, characterized in that the filters of two photodetectors, the outputs of which are connected to a difference unit for generating a Doppler signal, are made to transmit radiation only at the wavelength of a radiation source operating continuously, and the filter of the third photodetector is the remaining wavelengths of the source block radiation. 3. The diagnostic complex according to claim 1, characterized in that the difference block of the Doppler signal generating circuit contains two AC signal filters, two voltage dividers and a difference circuit of two signals, while the outputs of the photodetectors connected to the difference Doppler signal generating unit are connected to the corresponding AC signal filter and to the "X" input of the voltage divider, to the other "Y" input of which the output of the AC signal filter is connected, and the outputs of the dividers, each of which forms elations Z = Y / X, are connected to further inputs of the circuit forming the difference of two signals. 4. The diagnostic complex according to claim 1, characterized in that the optical fiber of the radiation transportation system connected to the radiation source is continuously operating, as well as this source itself is single-mode. 5. The diagnostic complex according to claim 1, characterized in that the optical fibers of the radiation transportation system are made with a metallized coating sprayed onto their shell with a thickness of 1-100 microns.

Images