RU2299736C1 - Method for preparing preparation for treatment of gastrointestinal diseases and disorders in agricultural young animals - Google Patents

Abstract

FIELD: veterinary science.

SUBSTANCE: method involves preparing a biological substrate wherein mixture of stuffing prepared from abomasum, duodenum and pancreas tissue are used. To the prepared biological substrate 2.5% hydrochloric acid solution is added in the ratio 1:12 and kept for 24 h at temperature 20-24°C at periodic stirring followed by filtration. Filtered off liquid is diluted with 0.9% sodium chloride solution in the ratio 1:10. Invention provides enhancing effectiveness of prophylaxis and treatment of gastrointestinal diseases in young animals. Invention can be used in prophylaxis and treatment of gastrointestinal diseases in calves and piglets.

EFFECT: improved preparing method, enhanced effectiveness of preparation.

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Description

The invention relates to veterinary medicine, namely to veterinary pharmacy, in particular to the production of a complex enzyme-tissue preparation for the prevention and treatment of gastrointestinal diseases in calves and piglets.

A known method of producing a preparation of abomin obtained from the mucous membranes of the abomasum of calves and lambs of young age (see, Chervyakov D.K., Evdokimova P.D., Vishner A.S. Medicines in Veterinary Medicine 1977, p.233).

The disadvantage of the drug is a limited range of therapeutic and prophylactic action, since the drug is prepared from the abomasum of calves and lambs of young age.

The known drug pancreatin, which is obtained from the pancreas of slaughter cattle (see Chervyakov D.K., Evdokimova P.D., Visner A.S. Medicines in veterinary medicine, 1977, p.234).

There is also a method of obtaining a drug from the mucous membrane of the stomach of pigs and gastric artificial juice in the form of an extract of the mucous membrane of the stomach of pigs, acidified with hydrochloric acid (see Chervyakov D.K., Evdokimova P.D., Vishner A.S. Medicines in veterinary medicine, 1977, p.234 - prototype).

The disadvantage of these drugs is the difficulty in procurement and the lack of raw materials, the drugs are good in medical practice and do not quite satisfy the need and effectiveness of the prevention and treatment of gastrointestinal diseases in calves and piglets born of hypotrophy, with impaired development of internal organs, in particular the stomach, duodenum , pancreas and other organs.

The technical solution of the problem of the invention is to increase the effectiveness of the prevention and treatment of gastrointestinal diseases in young animals by expanding the range and enhancing the therapeutic and prophylactic effect of the drug - increasing the body's resistance, digestion of gastric juice, stimulating and normalizing the function of the digestive tract, pancreatic juice and bile, strengthening antiseptic anti-fermentative action.

This object is achieved in that in a method for preparing a preparation for treating gastrointestinal diseases and disorders of young farm animals, including preparing a biological substrate from the digestive system and treating it with hydrochloric acid, a mixture of minced rennet, duodenum and pancreas is used as a biological substrate glands in the following ratio of components, wt.%:

minced rennet 50-55 duodenal meat 30-40 minced pancreas rest

at the same time, a 2.5% solution of hydrochloric acid in a ratio of 1:12 is added to the mixture of minced meat, then the biological substrate is kept at a temperature of 20-24 ° C for a day, it is stirred periodically, filtered and the filtered liquid is diluted with 0.9% sodium chloride solution in a ratio of 1 : 10 and pack.

The novelty of the claimed technical solution is due to the fact that the present drug, including a combination of tissues and mucous membranes of the abomasum, duodenum and pancreas, contains a large set of hormones, of which the main ones are pancreosimine and secretin, enzymes pepsin, chymosin, trypsin, amylase, etc. , as well as biologically active substances that restore impaired digestive functions, normalize metabolism and increase the body's resistance in young animals.

According to the scientific, technical and patent literature, no similar set of features has been found that allows us to judge the inventive level of the claimed technical solution.

As for the criterion of "industrial applicability", the components included in the preparation are approved by the State Pharmacopoeia (GF X1) for use in medical and veterinary practice.

The claimed drug is a complex preparation, which is a colorless liquid of slightly acidic taste with a specific odor and containing 2.5% free hydrochloric acid and all enzymes of the gastric and intestinal juice and pancreas, as well as biologically active substances.

Shelf life for 6 months in a dark place at a temperature of + 4-10 ° C.

The drug combines well with other etiopathogenetic treatments, has a comprehensive effect in the prevention and treatment of gastrointestinal diseases and disorders, increases the resistance of the young organism, digestibility of gastric and intestinal juice, stimulates and normalizes the function of the digestive tract, pancreatic juice and bile, strengthens antiseptic and anti-fermentative properties.

In therapeutic doses, it is non-toxic, does not have a pronounced local irritant effect on tissues, drug resistance does not form for it in microbes.

The factors that determine the preparation of a given property include the percentage ratio between the components that make up the sequence of the preparation process.

An example of a specific implementation of the method of preparation of the drug for the treatment of gastrointestinal diseases and disorders of young farm animals.

The main components of the drug are taken in optimal quantities, g:

minced rennet 51 duodenal meat 35 minced pancreas rest

if we take the main components in a minimal amount, mince the rennet - 50 g, mince the duodenum - 30 g, mince the pancreas - the rest, the effect will appear more slowly, as a result, the treatment period will increase, and if you take the maximum values, mince the rennet 55 g, mince of the duodenum - 40 g, mince of the pancreas - the rest, the effect will be manifested as at optimal values, so it is not economically feasible to take a large number of components.

When recalculating the ratio (1:12) weight. the amount of forcemeat mixture to the amount of 2.5% hydrochloric acid solution it turns out that the forcemeat mixture is taken in an amount of 100 g, loaded into a glass container and add 2.5% hydrochloric acid solution in an amount of 1 liter, the container is closed (loose) and left for 24 hours at room temperature, the contents are periodically mixed (2-3 times a day).

After a day, the solution is filtered through two layers of gauze and the filtered liquid is diluted with 10 liters of 0.9% sodium chloride solution (1:10 volume ratio). The resulting complex preparation, which is given the name “Intanpstock” (conditionally), is poured into sterile glass bottles, which are closed with rubber stoppers and rolled up with aluminum caps.

The target product is interpanstock, used to treat calves and piglets with dyspepsia (simple or mild toxic), catarrhal gastroenteritis, chronic eating disorder (hypotrophy).

The use of the complex preparation intepanstock positively affected the prevention and treatment of gastrointestinal diseases and disorders, the therapeutic effectiveness of the drug is manifested within 5-6 days and amounts to 97-98.5%.

Intepankstock can be combined with other drugs. When using Intepankstock in the prevention and treatment of animals, side effects in the latter have not been established (see table).

Table Therapeutic efficacy of interpanstock for dyspepsia of calves and piglets used during 2002-2003 in the SEC "Rodina" of the Kalinin district of the Krasnodar Territory Year Animal species Number of sick animals Used drugs Artificial gastric juice Intepankstock Number of animals The number of recovered Efficiency% Number of animals The number of recovered Efficiency% 2002 Calves 252 126 89 70.6 126 122 96.8 2002 Piglets 970 485 376 77.5 485 469 96.7 2003 Calves 576 288 269 93,4 288 284 98.6 2003 Piglets 1268 634 617 97.3 634 623 98.2

Claims (1)

A method of preparing a preparation for the treatment of gastrointestinal diseases and disorders of young farm animals, comprising preparing a biological substrate from the digestive system and treating it with hydrochloric acid, characterized in that a mixture of minced rennet, duodenum and pancreas is used as the biological substrate the ratio of components, wt.%: Stuffing rennet 50-55 Minced Duodenum 30-40 Mince pancreas Rest at the same time, a 2.5% solution of hydrochloric acid in a ratio of 1:12 is added to the mixture of minced meat, then the biological substrate is kept at a temperature of 20-24 ° C for a day, it is periodically stirred, filtered and the filtered liquid diluted with a 0.9% chloride solution sodium at a ratio of 1:10.