RU2013114131A - METHOD FOR PRODUCING METRONIDAZOLE - Google Patents
METHOD FOR PRODUCING METRONIDAZOLE Download PDFInfo
- Publication number
- RU2013114131A RU2013114131A RU2013114131/04A RU2013114131A RU2013114131A RU 2013114131 A RU2013114131 A RU 2013114131A RU 2013114131/04 A RU2013114131/04 A RU 2013114131/04A RU 2013114131 A RU2013114131 A RU 2013114131A RU 2013114131 A RU2013114131 A RU 2013114131A
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- RU
- Russia
- Prior art keywords
- nitroimidazole
- methyl
- alkylation
- neutralized
- purified
- Prior art date
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1. Способ получения метронидазола путем алкилирования 2-метил-4(5)-нитроимидазола этиленхлоргидрином при нагревании, избыток алкилирующего агента удаляют при пониженном давлении, а непрореагировавший 2-метил-4(5)-нитроимидазол отфильтровывают, после чего полученный раствор нейтрализуют, охлаждают и отфильтровывают, отличающийся тем, что алкилирование 2-метил-4(5)-нитроимидазола этиленхлоргидрином проводят в присутствии соляной кислоты, а выделенный продукт очищают.2. Способ по п.1, в котором алкилирование 2-метил-4(5)-нитроимидазола этиленхлоргидрином проводят при температуре 120-125°C в течение 16-22 ч.3. Способ по п.1, в котором полученный раствор нейтрализуют подщелачиванием 25%-ным раствором аммиака до pH=10 с последующей выдержкой в течение 14-18 ч при 0-5°C.4. Способ по п.1, в котором выделенный продукт очищают перекристаллизацией из воды в присутствии активированного угля.1. The method of producing metronidazole by alkylation of 2-methyl-4 (5) -nitroimidazole with ethylene chlorohydrin when heated, the excess alkylating agent is removed under reduced pressure, and unreacted 2-methyl-4 (5) -nitroimidazole is filtered off, after which the resulting solution is neutralized, cooled and filtered, characterized in that the alkylation of 2-methyl-4 (5) -nitroimidazole with ethylene chloride is carried out in the presence of hydrochloric acid, and the isolated product is purified. The method according to claim 1, wherein the alkylation of 2-methyl-4 (5) -nitroimidazole with ethylene chloride is carried out at a temperature of 120-125 ° C for 16-22 hours. The method according to claim 1, in which the resulting solution is neutralized by alkalization with a 25% solution of ammonia to pH = 10, followed by exposure for 14-18 hours at 0-5 ° C. The method according to claim 1, wherein the isolated product is purified by recrystallization from water in the presence of activated carbon.
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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RU2013114131/04A RU2531616C1 (en) | 2013-03-29 | 2013-03-29 | Method of producing metronidazole |
Applications Claiming Priority (1)
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RU2013114131/04A RU2531616C1 (en) | 2013-03-29 | 2013-03-29 | Method of producing metronidazole |
Publications (2)
Publication Number | Publication Date |
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RU2013114131A true RU2013114131A (en) | 2014-10-10 |
RU2531616C1 RU2531616C1 (en) | 2014-10-27 |
Family
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Family Applications (1)
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RU2013114131/04A RU2531616C1 (en) | 2013-03-29 | 2013-03-29 | Method of producing metronidazole |
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RU (1) | RU2531616C1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114573511A (en) * | 2022-03-16 | 2022-06-03 | 安徽贝克制药股份有限公司 | Continuous synthesis method of metronidazole |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105001087B (en) * | 2015-07-10 | 2016-08-24 | 黄冈银河阿迪药业有限公司 | Comprehensive utilization metronidazole hydroxylation synthetic wastewater produces the method and device of formate ester |
CN108276340A (en) * | 2018-03-23 | 2018-07-13 | 兰亚朝 | Produce the synthetic method of metronidazole API |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
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DE2001432A1 (en) * | 1970-01-08 | 1971-07-15 | Klosa Josef Dipl Chem Dr Rer N | 1-(2-hydroxyethyl)-2-alkyl-5-nitroimida- - zoles prepn |
FR2625998B1 (en) * | 1988-01-15 | 1990-06-08 | Rhone Poulenc Sante | PROCESS FOR THE PREPARATION OF HYDROXYALKYL-1 METHYL-2 NITRO-5 IMIDAZOLES |
-
2013
- 2013-03-29 RU RU2013114131/04A patent/RU2531616C1/en active
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114573511A (en) * | 2022-03-16 | 2022-06-03 | 安徽贝克制药股份有限公司 | Continuous synthesis method of metronidazole |
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RU2531616C1 (en) | 2014-10-27 |
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