PT2235064E - Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática - Google Patents

Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática Download PDF

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Publication number
PT2235064E
PT2235064E PT97006431T PT09700643T PT2235064E PT 2235064 E PT2235064 E PT 2235064E PT 97006431 T PT97006431 T PT 97006431T PT 09700643 T PT09700643 T PT 09700643T PT 2235064 E PT2235064 E PT 2235064E
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Portugal
Prior art keywords
making antibody
electrostatic steering
steering effects
heterodimeric molecules
heterodimeric
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PT97006431T
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English (en)
Inventor
Kannan Gunasekaran
Wittekind Michael
Yan Wei
Pentony Martin
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Amgen Inc
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Publication of PT2235064E publication Critical patent/PT2235064E/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PT97006431T 2008-01-07 2009-01-06 Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática PT2235064E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1956908P 2008-01-07 2008-01-07
US12030508P 2008-12-05 2008-12-05

Publications (1)

Publication Number Publication Date
PT2235064E true PT2235064E (pt) 2016-03-01

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PT97006431T PT2235064E (pt) 2008-01-07 2009-01-06 Método de preparação de moléculas heterodiméricas de fc de anticorpos utilizando efeitos de indução eletrostática

Country Status (14)

Country Link
US (2) US8592562B2 (pt)
EP (3) EP2235064B1 (pt)
JP (3) JP6157046B2 (pt)
AU (1) AU2009204501B2 (pt)
CA (1) CA2709847C (pt)
CY (1) CY1117162T1 (pt)
DK (1) DK2235064T3 (pt)
ES (2) ES2563027T3 (pt)
HU (1) HUE028536T2 (pt)
MX (1) MX350962B (pt)
PL (1) PL2235064T3 (pt)
PT (1) PT2235064E (pt)
SI (1) SI2235064T1 (pt)
WO (1) WO2009089004A1 (pt)

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