PL438500A1 - Pharmaceutical composition based on vegetable oil and triblock copolymer, multi-phase composition in the form of an emulgel and method for preparing the composition - Google Patents

Pharmaceutical composition based on vegetable oil and triblock copolymer, multi-phase composition in the form of an emulgel and method for preparing the composition

Info

Publication number
PL438500A1
PL438500A1 PL438500A PL43850021A PL438500A1 PL 438500 A1 PL438500 A1 PL 438500A1 PL 438500 A PL438500 A PL 438500A PL 43850021 A PL43850021 A PL 43850021A PL 438500 A1 PL438500 A1 PL 438500A1
Authority
PL
Poland
Prior art keywords
composition
vegetable oil
phase
poloxamer
mpa
Prior art date
Application number
PL438500A
Other languages
Polish (pl)
Inventor
Katarzyna Małolepsza-Jarmołowska
Michał Smoleński
Original Assignee
Uniwersytet Medyczny Im.Piastów Śląskich We Wrocławiu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Medyczny Im.Piastów Śląskich We Wrocławiu filed Critical Uniwersytet Medyczny Im.Piastów Śląskich We Wrocławiu
Priority to PL438500A priority Critical patent/PL438500A1/en
Priority to EP22786123.4A priority patent/EP4370097A1/en
Priority to PCT/PL2022/000040 priority patent/WO2023287310A1/en
Publication of PL438500A1 publication Critical patent/PL438500A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gynecology & Obstetrics (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

Pierwszym przedmiotem wynalazku jest kompozycja emulsyjna na bazie oleju roślinnego i poloksameru 407 lub poloksameru 188, charakteryzująca się tym, że kompozycja zawiera od 20 do 60 części masowych oleju roślinnego, który stanowi olej rzepakowy, od 1 do 20 części masowych poloksameru 407 albo poloksameru 188, od 50 do 65 części masowych wody oczyszczonej, od 1 do 20 części masowych surfaktantu. Drugim przedmiotem wynalazku jest kompozycja wielofazowa zawierająca kompozycję na bazie oleju roślinnego wg pierwszego przedmiotu wynalazku, charakteryzująca się tym, że zawiera fazę żelową i fazę emulsyjną, według pierwszego przedmiotu wynalazku, w stosunku masowym od 1:1 do 1:4, i kompozycja ma postać emulżelu, przy czym faza żelowa zawiera opcjonalnie substancje hydrofilizujące, przy czym kompozycja w postaci emulżelu ma lepkość dynamiczną od 250 mPa•s do 750 mPa•s, korzystnie od 300 mPa•s do 700 mPa•s. Wynalazek obejmuje również sposoby wytwarzania powyższych kompozycji.The first object of the invention is an emulsion composition based on vegetable oil and poloxamer 407 or poloxamer 188, characterized in that the composition contains from 20 to 60 parts by mass of vegetable oil, which is rapeseed oil, from 1 to 20 parts by mass of poloxamer 407 or poloxamer 188, from 50 to 65 parts by mass of purified water, from 1 to 20 parts by mass of surfactant. The second object of the invention is a multi-phase composition comprising a vegetable oil-based composition according to the first object of the invention, characterized in that it comprises a gel phase and an emulsion phase according to the first object of the invention in a weight ratio of 1:1 to 1:4, and the composition is in the form emulsion, wherein the gel phase optionally comprises hydrophilizing agents, wherein the emulsion composition has a dynamic viscosity of from 250 mPa•s to 750 mPa•s, preferably from 300 mPa•s to 700 mPa•s. The invention also includes methods of making the above compositions.

PL438500A 2021-07-16 2021-07-16 Pharmaceutical composition based on vegetable oil and triblock copolymer, multi-phase composition in the form of an emulgel and method for preparing the composition PL438500A1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PL438500A PL438500A1 (en) 2021-07-16 2021-07-16 Pharmaceutical composition based on vegetable oil and triblock copolymer, multi-phase composition in the form of an emulgel and method for preparing the composition
EP22786123.4A EP4370097A1 (en) 2021-07-16 2022-07-15 A pharmaceutical composition based on a vegetable oil and a triblock copolymer, a multiphase emulgel composition and a method of preparation of the composition
PCT/PL2022/000040 WO2023287310A1 (en) 2021-07-16 2022-07-15 A pharmaceutical composition based on a vegetable oil and a triblock copolymer, a multiphase emulgel composition and a method of preparation of the composition

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL438500A PL438500A1 (en) 2021-07-16 2021-07-16 Pharmaceutical composition based on vegetable oil and triblock copolymer, multi-phase composition in the form of an emulgel and method for preparing the composition

Publications (1)

Publication Number Publication Date
PL438500A1 true PL438500A1 (en) 2023-01-23

Family

ID=83598658

Family Applications (1)

Application Number Title Priority Date Filing Date
PL438500A PL438500A1 (en) 2021-07-16 2021-07-16 Pharmaceutical composition based on vegetable oil and triblock copolymer, multi-phase composition in the form of an emulgel and method for preparing the composition

Country Status (3)

Country Link
EP (1) EP4370097A1 (en)
PL (1) PL438500A1 (en)
WO (1) WO2023287310A1 (en)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL210178B1 (en) * 2007-06-15 2011-12-30 Politechnika Wroclawska Production method of emulsion stabilized with surfactants
ES2459876T3 (en) * 2007-11-28 2014-05-12 Commonwealth Scientific And Industrial Research Organisation Nanoemulsions
AU2009205314A1 (en) * 2008-01-14 2009-07-23 Foamix Ltd. Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses
CN107260667A (en) * 2017-05-16 2017-10-20 杭州汉光生物医药科技有限公司 Menthol spray agent and its application prepared by a kind of menthol Submicron Emulsion
WO2020112595A1 (en) * 2018-11-30 2020-06-04 L'oreal Thermoresponsive oil-in-water nanoemulsion
AU2020287079A1 (en) * 2019-06-06 2022-01-06 Hexo Operations Inc. Thermogelling cannabinoid composition and method of manufacture and use thereof

Also Published As

Publication number Publication date
WO2023287310A1 (en) 2023-01-19
EP4370097A1 (en) 2024-05-22

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