PL310896A1 - Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors - Google Patents

Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors

Info

Publication number
PL310896A1
PL310896A1 PL94310896A PL31089694A PL310896A1 PL 310896 A1 PL310896 A1 PL 310896A1 PL 94310896 A PL94310896 A PL 94310896A PL 31089694 A PL31089694 A PL 31089694A PL 310896 A1 PL310896 A1 PL 310896A1
Authority
PL
Poland
Prior art keywords
compounds useful
cyclic compounds
glycoprotein inhibitors
platelet iib
iiia glycoprotein
Prior art date
Application number
PL94310896A
Inventor
William Frank Degrado
Sharon Anne Jackson
Shaker Ahmed Mousa
Anju Parthasarathy
Michael Sworin
Maria Rafalski
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of PL310896A1 publication Critical patent/PL310896A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
PL94310896A 1993-03-29 1994-03-28 Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors PL310896A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3844893A 1993-03-29 1993-03-29

Publications (1)

Publication Number Publication Date
PL310896A1 true PL310896A1 (en) 1996-01-08

Family

ID=21900014

Family Applications (1)

Application Number Title Priority Date Filing Date
PL94310896A PL310896A1 (en) 1993-03-29 1994-03-28 Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors

Country Status (10)

Country Link
EP (1) EP0691987A1 (en)
JP (1) JPH08508498A (en)
AU (1) AU6415894A (en)
CA (1) CA2159070A1 (en)
FI (1) FI954556A0 (en)
HU (1) HUT72896A (en)
NO (1) NO953832L (en)
NZ (1) NZ263456A (en)
PL (1) PL310896A1 (en)
WO (1) WO1994022910A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0691986B1 (en) * 1993-03-29 1998-12-02 The Du Pont Merck Pharmaceutical Company NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
IL129877A (en) * 1996-11-27 2004-08-31 Aventis Pharm Prod Inc PHARMACEUTICAL COMPOSITION COMPRISING A COMPOUND HAVING ANTI-Xa ACITIVITY AND A PLATELET AGGREGATION ANTAGONIST COMPOUND
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
KR101623985B1 (en) 2007-03-28 2016-05-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Stitched polypeptides
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
EP2504035B8 (en) 2009-11-10 2019-06-05 Allegro Pharmaceuticals, LLC Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites
JP2013535514A (en) 2010-08-13 2013-09-12 エイルロン セラピューティクス，インコーポレイテッド Peptidomimetic macrocycle
AU2012253511A1 (en) 2011-05-09 2014-01-09 Allegro Pharmaceuticals, Inc. Integrin receptor antagonists and their methods of use
JP6342808B2 (en) 2011-10-18 2018-06-13 エイルロン セラピューティクス，インコーポレイテッド Peptidomimetic macrocycle
AU2013221433B2 (en) 2012-02-15 2018-01-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
BR112014020103A2 (en) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. peptidomimetic macrocycles
BR112015009470A2 (en) 2012-11-01 2019-12-17 Aileron Therapeutics Inc disubstituted amino acids and their methods of preparation and use
CN107106642B (en) 2014-09-24 2021-02-26 艾瑞朗医疗公司 Peptidomimetic macrocycles and formulations thereof
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
CA2979847A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636066B1 (en) * 1988-09-02 1991-10-25 Centre Nat Rech Scient CYCLOPEPTIDE DERIVATIVES FOR USE AS SELECTIVE INHIBITORS AGAINST ACTIVE SERINE PROTEASES
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
AU6470590A (en) * 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
NO953832L (en) 1995-11-28
AU6415894A (en) 1994-10-24
NZ263456A (en) 1996-11-26
FI954556A (en) 1995-09-26
WO1994022910A1 (en) 1994-10-13
NO953832D0 (en) 1995-09-28
CA2159070A1 (en) 1994-10-13
FI954556A0 (en) 1995-09-26
HU9502832D0 (en) 1995-11-28
JPH08508498A (en) 1996-09-10
HUT72896A (en) 1996-06-28
EP0691987A1 (en) 1996-01-17

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