PE20110568A1 - Agentes terapeuticos 414 - Google Patents

Agentes terapeuticos 414

Info

Publication number
PE20110568A1
PE20110568A1 PE2011000125A PE2011000125A PE20110568A1 PE 20110568 A1 PE20110568 A1 PE 20110568A1 PE 2011000125 A PE2011000125 A PE 2011000125A PE 2011000125 A PE2011000125 A PE 2011000125A PE 20110568 A1 PE20110568 A1 PE 20110568A1
Authority
PE
Peru
Prior art keywords
alkyl
chloropyridin
propanamide
pyrimidin
atom
Prior art date
Application number
PE2011000125A
Other languages
English (en)
Inventor
Stuart Norman Lile Bennett
Peter Gustaf Bonn
Mikael Dan Brink
Roger John Butlin
Leonie Campbell
Robert Darren Morse Davies
Jonas Rickard Fagerhag
Ulrik Jurva
Helen Claire Pointon
Graeme Richard Robb
Volker Schnecke
Henriksson Anette Marie Svensson
Rolf Peter Walker
Michael James Waring
Christer Ralf Westerlund
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of PE20110568A1 publication Critical patent/PE20110568A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A Y B SON CADA UNO N, CR6; X ES C, N; Y ES CH, N; Z ES C, N; R1 ES ALQUILO C1-C6, ARILO, ARILALQUILO C1-C6, ENTRE OTROS; R2 ES ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO POR 1-2 HIDROXI, CARBOXI, CARBAMOILO, ENTRE OTROS; R3 ES HETEROARILO MONOCICLICO UNIDO A C DE 5-6 MIEMBROS, QUE CONTIENE UN ATOMO DE N EN LA POSICION 2, HETROARILO BICICLICO UNIDO A C DE 8-10 MIEMBROS QUE CONTIENE UN ATOMO DE NEN LA POSICION 2, ENTRE OTROS; R5 ES H, ALCOXI C1-C4, ALQUILO C1-C4; L ES S, O, NH, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: (2S)-N-(5-CLOROPIRIDIN-2-IL)-2-(1-(3-CLOROPIRIDIN-2-IL)-1H-PIRAZOLO[3,2-d]-PIRIMIDIN-4-ILOXI)-3-(3-HIDROXIAZETIDIN-1-IL)PROPANAMIDA; (2S)-2-[1-(2-CLOROFENIL)PIRAZOLO[3,4-d]PIRIMIDIN-4-IL]OXI-N-(5-CLORO-2-PIRIDIL)-3-(3-HIDROXIAZETIDIN-1-IL)PROPANAMIDA; ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO O PREVENCION DE UNA ENFERMEDAD O AFECCION MEDICA MEDIADA POR GLUCOQUINASA (GLK O GK) UTILES EN EL TRATAMIENTO DE DIABETES TIPO 2
PE2011000125A 2008-08-04 2009-08-03 Agentes terapeuticos 414 PE20110568A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8591908P 2008-08-04 2008-08-04
US16804809P 2009-04-09 2009-04-09

Publications (1)

Publication Number Publication Date
PE20110568A1 true PE20110568A1 (es) 2011-09-07

Family

ID=41563374

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011000125A PE20110568A1 (es) 2008-08-04 2009-08-03 Agentes terapeuticos 414

Country Status (23)

Country Link
US (1) US8143263B2 (es)
EP (1) EP2324028A2 (es)
JP (1) JP2011529955A (es)
KR (1) KR20110052676A (es)
CN (1) CN102171213A (es)
AR (1) AR072900A1 (es)
AU (1) AU2009278929B2 (es)
BR (1) BRPI0917589A2 (es)
CA (1) CA2732165A1 (es)
CL (1) CL2011000249A1 (es)
CO (1) CO6351730A2 (es)
CR (1) CR20110065A (es)
DO (1) DOP2011000047A (es)
EA (1) EA201100097A1 (es)
EC (1) ECSP11010809A (es)
IL (1) IL210778A0 (es)
MX (1) MX2011001333A (es)
PE (1) PE20110568A1 (es)
SV (1) SV2011003829A (es)
TW (1) TW201011026A (es)
UY (1) UY32032A (es)
WO (1) WO2010015849A2 (es)
ZA (1) ZA201101663B (es)

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GB0902434D0 (en) * 2009-02-13 2009-04-01 Astrazeneca Ab Chemical process
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WO2010116177A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab A pyrazolo [4,5-e] pyrimidine derivative and its use to treat diabetes and obesity
WO2010116176A1 (en) * 2009-04-09 2010-10-14 Astrazeneca Ab Pyrazolo [4, 5-e] pyrimidine derivative and its use to treat diabetes and obesity
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103450124B (zh) * 2013-08-30 2016-03-09 江苏九九久科技股份有限公司 决奈达隆合成方法
EP3294062A4 (en) * 2015-05-14 2019-02-13 The Regents of the University of California MIMETICS OF BRASSINOSTEROIDS
TWI758751B (zh) * 2015-12-16 2022-03-21 日商日本曹達股份有限公司 芳基唑化合物及有害生物防除劑
CN106749263A (zh) * 2016-11-13 2017-05-31 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
CN106749264A (zh) * 2016-11-13 2017-05-31 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
CN106749265A (zh) * 2016-11-13 2017-05-31 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
CN106361753A (zh) * 2016-11-13 2017-02-01 曹艳 一种别嘌醇衍生物及其在制备抗肿瘤药物中的用途
EP3357928B1 (en) 2017-02-03 2021-01-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel dyes with phosphinic acid, phosphinate, phosphonate and phosphonamidate substituents as auxochromic groups and methods for preparing the same
CN108033966A (zh) * 2018-01-05 2018-05-15 天津药明康德新药开发有限公司 7-叔丁基3-乙基8-甲基5,6二氢三唑并吡嗪3,7(8h)二甲酸基酯的合成方法
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BRPI0917589A2 (pt) 2015-11-17
UY32032A (es) 2010-03-26
CN102171213A (zh) 2011-08-31
AU2009278929B2 (en) 2012-07-05
MX2011001333A (es) 2011-03-15
CL2011000249A1 (es) 2011-07-15
WO2010015849A2 (en) 2010-02-11
CO6351730A2 (es) 2011-12-20
US8143263B2 (en) 2012-03-27
EP2324028A2 (en) 2011-05-25
AU2009278929A1 (en) 2010-02-11
KR20110052676A (ko) 2011-05-18
TW201011026A (en) 2010-03-16
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EA201100097A1 (ru) 2011-10-31
CA2732165A1 (en) 2010-02-11
AU2009278929A8 (en) 2011-03-10
JP2011529955A (ja) 2011-12-15
US20100093757A1 (en) 2010-04-15
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IL210778A0 (en) 2011-03-31
SV2011003829A (es) 2011-07-01

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