PE20050948A1 - CARBAMOIL-AMINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV - Google Patents
CARBAMOIL-AMINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IVInfo
- Publication number
- PE20050948A1 PE20050948A1 PE2004000875A PE2004000875A PE20050948A1 PE 20050948 A1 PE20050948 A1 PE 20050948A1 PE 2004000875 A PE2004000875 A PE 2004000875A PE 2004000875 A PE2004000875 A PE 2004000875A PE 20050948 A1 PE20050948 A1 PE 20050948A1
- Authority
- PE
- Peru
- Prior art keywords
- cycloalkyl
- carbamoil
- inhibitors
- trans
- amino
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE CARBAMOIL-AMINA DE FORMULA (I), EN DONDE R1 ES H, ALQUILO(C1-C6), CICLOALQUILO (C3-C12) OPCIONALMENTE SUSTITUIDOS, ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C12), OPCIONALMENTE SUSTITUIDOS; R3 ES CICLOALQUILO(C3-C12) OPCIONALMENTE SUSTITUIDO; R4 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C12), HETEROCICLO SATURADO DE 3 A 7 MIEMBROS, OPCIONALMENTE SUSTITUIDOS. SON COMPUESTOS PREFERIDOS: ACIDO 2-{TRANS-4-[(S)-AMINO-(N-CICLOBUTIL-N-METILACARBAMOIL)METIL]CICLOHEXILMETOXIMETIL}BENZOICO, ACIDO 3-{TRANS-4-[(S)-AMINO-(N-CICLOBUTIL-N-METIL-CARBAMOIL)METIL]CICLOHEXILMETOXIMETIL-5-DIMETILAMINOBENZOICO, (2-METANOSULFONIL)FENILAMIDA DE ACIDO TRANS 4-[(S)-AMINO-(N-CICLOBUTIL-N-METILCARBAMOIL)METIL]CICLOHEXANOCARBOXILICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA ENZIMA DIPEPTIDIL PEPTIDASA DPP-IV, POR LO QUE SON UTILES PARA EL TRATAMIENTO DE LA DIABETES TIPO II, OBESIDAD O SIMILARESREFERS TO COMPOUNDS DERIVED FROM CARBAMOIL-AMINE OF FORMULA (I), WHERE R1 IS H, ALKYL (C1-C6), OPTIONALLY SUBSTITUTED CYCLOALKYL (C3-C12), AMONG OTHERS; R2 IS H, ALKYL (C1-C6), CYCLOALKYL (C3-C12), OPTIONALLY SUBSTITUTED; R3 IS CYCLOALKYL (C3-C12) OPTIONALLY SUBSTITUTED; R4 IS H, ALKYL (C1-C6), CYCLOALKYL (C3-C12), SATURATED HETEROCYCLE OF 3 TO 7 MEMBERS, OPTIONALLY REPLACED. PREFERRED COMPOUNDS ARE: 2- {TRANS-4 - [(S) -AMINO- (N-CYCLOBUTYL-N-METHYLACARBAMOYL) METHYL] CYCLOHEXYLMETOXIMETHYL} BENZOIC ACID, 3- {TRANS-4 - [(S) -AMINO- ( N-CYCLOBUTYL-N-METHYL-CARBAMOYL) METHYL] CYCLOHEXYLMETOXIMETHYL-5-DIMETHYLAMINOBENZOIC, (2-METHANOSULFONYL) TRANS 4 ACID PHENYLAMIDE - [(S) -AMINO- (N-CYCLOBUTILBUTYL-N-METHYLOCAR) HEXYLBUTYL-N-METHYLOCARYL OTHERS. IT ALSO REFERS TO A PHARMACEUTICAL COMPOSITION. THESE COMPOUNDS ARE INHIBITORS OF THE DIPEPTIDIL PEPTIDASE DPP-IV ENZYME, SO THEY ARE USEFUL FOR THE TREATMENT OF TYPE II DIABETES, OBESITY, OR SIMILAR
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003317407 | 2003-09-09 | ||
JP2003395879 | 2003-11-26 | ||
JP2004114685 | 2004-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20050948A1 true PE20050948A1 (en) | 2005-12-16 |
Family
ID=34317220
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2004000875A PE20050948A1 (en) | 2003-09-09 | 2004-09-09 | CARBAMOIL-AMINE COMPOUNDS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE IV |
Country Status (4)
Country | Link |
---|---|
AR (1) | AR046330A1 (en) |
PE (1) | PE20050948A1 (en) |
TW (1) | TW200530157A (en) |
WO (1) | WO2005025554A2 (en) |
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---|---|---|---|---|
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JP2017538678A (en) * | 2014-11-05 | 2017-12-28 | フレクサス・バイオサイエンシーズ・インコーポレイテッドFlexus Biosciences, Inc. | Immunomodulator |
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MX2018011177A (en) * | 2016-04-04 | 2018-11-21 | Res Triangle Inst | Neuropeptide s receptor (npsr) agonists. |
WO2018151873A1 (en) | 2017-02-16 | 2018-08-23 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
MX2019011867A (en) | 2017-04-03 | 2020-01-09 | Coherus Biosciences Inc | Pparî³ agonist for treatment of progressive supranuclear palsy. |
EP3461819B1 (en) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
US10683267B1 (en) * | 2019-11-21 | 2020-06-16 | King Abdulaziz University | Antidiabetic compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9416897D0 (en) * | 1994-08-20 | 1994-10-12 | British Biotech Pharm | Metalloproteinase inhibitors |
SE9701245D0 (en) * | 1997-04-04 | 1997-04-04 | Bjoern Classon | antivirals |
CO5150173A1 (en) * | 1998-12-10 | 2002-04-29 | Novartis Ag | COMPOUNDS N- (REPLACED GLYCLE) -2-DIPEPTIDYL-IV PEPTIDASE INHIBITING CYANOPIRROLIDINS (DPP-IV) WHICH ARE EFFECTIVE IN THE TREATMENT OF CONDITIONS MEDIATED BY DPP-IV INHIBITION |
EP1434769A2 (en) * | 2001-10-02 | 2004-07-07 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
CA2837936A1 (en) * | 2001-11-26 | 2003-06-05 | Trustees Of Tufts College | Peptidomimetic inhibitors of post-proline cleaving enzymes |
-
2004
- 2004-09-09 TW TW093127247A patent/TW200530157A/en unknown
- 2004-09-09 PE PE2004000875A patent/PE20050948A1/en not_active Application Discontinuation
- 2004-09-09 WO PCT/JP2004/013480 patent/WO2005025554A2/en not_active Application Discontinuation
- 2004-09-09 AR ARP040103231A patent/AR046330A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR046330A1 (en) | 2005-12-07 |
WO2005025554A3 (en) | 2005-07-28 |
TW200530157A (en) | 2005-09-16 |
WO2005025554A2 (en) | 2005-03-24 |
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