NZ702127A - Methods and compositions for diagnosis and treatment of cancer - Google Patents

Abstract

Disclosed is a method for diagnosis, detection or monitoring of a tumour disease comprising the detection of and/or determination of the quantity of one or more parameters selected from the group consisting of: (i) a nucleic acid which codes for a peptide comprising the amino acid sequence of a tumour antigen, (ii) a peptide comprising the amino acid sequence of a tumour antigen, (iii) an antibody which binds to a peptide comprising the amino acid sequence of a tumour antigen, (iv) a T cell that recognizes a peptide comprising the amino acid sequence of a tumour antigen or a functional fragment of said peptide and/or (v) a cell which presents a peptide comprising the amino acid sequence of a tumour antigen or a functional fragment of said peptide, -in a biological sample isolated from a patient, wherein the biological sample is from a tissue or organ and wherein the cells when the tissue or organ is free of tumours do not express said tumour antigen and/or a nucleic acid encoding said tumour antigen, -wherein said tumour antigen comprises an amino acid sequence encoded by a nucleic acid which comprises the nucleic acid sequence according to SEQ ID NO: 1 of the sequence listing or a functional variant of said nucleic acid sequence, and -wherein the detection of the presence of the one or more parameters in the biological sample, and/or the determination of an increased amount of the one or more parameters in the biological sample, is indicative for the presence of the tumour disease.