NZ622514B2 - Automatic injection device - Google Patents

Abstract

Automatic injection device includes a housing, a syringe, a plunger, and a syringe carrier. The housing includes a barrel between a first end and a second end. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposed within the housing and has a reservoir. The plunger is at least partially disposed within the syringe and includes a visual indicator. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position. The syringe carrier is substantially transparent. The syringe carrier can have first and second legs and an extension disposed therebetween, and at least a portion of the extension is configured to align with the window and the reservoir when the syringe carrier is in the first position. a reservoir. The plunger is at least partially disposed within the syringe and includes a visual indicator. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position. The syringe carrier is substantially transparent. The syringe carrier can have first and second legs and an extension disposed therebetween, and at least a portion of the extension is configured to align with the window and the reservoir when the syringe carrier is in the first position.

Description

PCT/U52012/056756 AUTOMATIC INJECTION DEVICE CROSS~REFERENCE TO RELATED APPLICATIONS This application claims priority to US. Provisional ation No, 61/538,098, filed on September 22, 2011, and US. Provisional Application No. 61/695,911, filed on August 31, 2012, each ofwhich is incorporated by reference herein in its entirety.

BACKGROUND Field of the Disclosed Subject Matter The present disclosed subject matter relates to an automatic injection device for injecting a nce, such as a therapeutic agent, into a patient.

Descrigtion of Related Art One ofthe most common routes ofadministration for therapeutic agents, such as medications, is by ion, such as enous, subcutaneous or intramuscular injection. A syringe containing the medication is used for the injection, which typically is carried out by trained l personnel. In n instances, a patient is trained in the use of the syringe to allow for self—inj ection. Moreover, certain medications are formulated in pro-filled syringes for patient use, to avoid the need for the patient to fill the syringe. Some ts, however, can be averse to carrying out self-injection, particularly if the patient has a fear ofneedles or limited ity. tic injection devices offer an alternative to a syringe for delivering a therapeutic agent, Automatic injection devices have been used, for example, to deliver medications under emergency conditions, such as to administer epinephrine to counteract the effects of a severe allergic reaction, for example, as caused by a food allergy. Automatic ion devices also have been descn'bed for use in administering antiarrhythmic medications and selective thrornboiytic agents during a heart attack (see cg, US. Pat. Nos. 3,910,260; 4,004,577; 4,689,042; 4,755,169 and 4,795,433). Various types of automatic injection devices also are described in, for e, U.S. Pat. Nos. 3,941,130; 4,261,358; 5,085,642; 5,092,843; ,102,393; 5,267,963; 6,149,626; 6,270,479; and 6,371,939, each of which is incorporated by reference herein in its entirety.

In general, prior automatic injection devices, when ed, have a needle of a syringe configured to move forward and project from a protective housing prior to actuation of the piston of the syringe to eject a dose of liquid through the needle. Movement of the syringe toward the patient's skin such that the needle is exposed before pressurizing a liquid charge inside the e can help prevent the liquid from being discharged from the needle before the actual injection takes place.

However, there s a need for further improvement of known tic injection devices. For example, it can be desirable to inspect the contents of the automatic injection device prior to use. Also, it can be desirable to indicate when ion is completed. Such features are available in certain automatic injection s, the features depend upon larger volume doses. However, there s a need for an automatic injection device suitable for different volume doses and/or a wider range of dose volumes.

OBJECT It is an object of the present invention to at least substantially satisfy one or more of the above needs.

SUMMARY In accordance with the present invention, there is provided a n automatic ion device comprising: a housing having a first end, a second end, and a barrel between the first end and the second end, the barrel comprising an elongated window to allow viewing of contents inside the housing; a syringe disposed within the housing and having a first end, a second end, and a reservoir between the first end and the second end; a plunger at least partially ed within the syringe and comprising a visual indicator on a portion of the plunger; and a syringe carrier disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first position and a second position, the 11048261_1:hxa syringe carrier being substantially transparent and having at least a first opening configured to align with the window and the oir when the syringe carrier is in the first position.

Additionally or alternatively, in some embodiments the syringe carrier can be transparent.

In another embodiment, the disclosed subject matter includes an automatic ion device comprising a housing, a syringe, a plunger, and a syringe carrier. The housing includes a first end, a second end, and a barrel between the first end and the second end. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposed within the housing and has a first end, a second end, and a reservoir etween. The plunger is at least partially disposed within the syringe and includes a visual indicator disposed on a portion of the plunger. The syringe carrier is disposed within the housing and configured to contain the e and displace the syringe within the housing between a first position and a second position. The syringe r is substantially transparent and has first and second legs and an extension ed therebetween. At least a n of the extension is configured to align with the window and the reservoir when the syringe carrier is in the first position. In some embodiments, the syringe carrier further includes a transparent wall, and at least a portion of the transparent wall is configured to align with the window and the visual indicator when the syringe carrier is in the second position For example and as embodied here, the at least one opening can include a first opening and a second opening, and the syringe carrier can include a middle portion between the first and second openings. The middle portion can be sized to resist deformation of the e carrier. The first opening can be oned nearer to the first end of the housing than the second opening, n the first end is to be positioned proximate an injection site. The syringe carrier can also include first and second legs, wherein the first and second legs can define at least a portion of the first opening. The syringe carrier can include onal openings to pond with the window or windows of the housing. For example, if a window is provided on a front and a rear of the housing, then corresponding first and second openings can be provided on the front and rear of the syringe carrier, respectively. Hence, a first pair 11048261_1:hxa W0 2013/044172 PCT/U52012/056756 of legs can define a front first opening, and a second pair of legs can define a rear first opening.

Additionaily and as embodied here, the autoinjection device includes a liquid beneficial agent in the reservoir. The syringe carrier can be configured to allow viewing of substantially all ofthe liquid beneficial agent in the reservoir when the syringe carrier is in the first position. For e and not limitation, the iiquid beneficial agent can have a volume of 0.4 mL. Alternatively, in some embodiments, the liquid beneficial agent can have a volume of 0.8 mL. The liquid beneficial agent can include a protein. In some embodiments, the liquid beneficial agent can include a TNF inhibitor or the like, such as adalimumab.

Furthermore and as embodied here, the automatic injection device can e a cap having an outer portion, and the first end of the housing can be configured to receive the outer portion of the cap. The outer portion of the cap can include a cap notch to align with a portion of the elongated window when the cap is received by the g to prevent obstruction of the window. The cap can also e an inner portion. The inner portiou can include a spiit hub projecting beyond the outer n, and the split hub can define a hub opening. The hub opening can be aligned with at least a portion of the elongated window when the cap is received by the housing to prevent obstruction of the window. The inner portion of the cap can also e a circumferential ridge. The automatic injection device can include a needle projecting from the first end ofthe syringe and a needle shield surrounding at least a portion of the . The circumferential ridge can be configured to e the needle shield within the inner n ofthe cap when the cap is received by the housing. The needle shield can be retained in the inner portion of the cap when the cap is removed from the housing.

It is to be understood that both the foregoing l desoription and the following detailed description are ary and are intended to provide further explanation of the disclosed subject matter claimed.

The accompanying drawings, which are incorporated in and constitute part of this specification, are included to illustrate and provide a further understanding ofthe disclosed subject matter. er with the description, the drawings serve to explain the principles of the disclosed subject matter.

BRIEF DESCRIPTION OF THE DRAWINGS Preferred embodiments of the present invention will now be described, by way of example only, with reference to the anying gs wherein: is a front view of the automatic injection device according to an illustrative ment of the disclosed subject . is a cross-sectional side view taken along line B-B of . is a perspective view of the automatic injection device of according to an illustrative embodiment of the disclosed subject matter. is a front view of a syringe housing assembly of automatic injection device of an embodiment of the disclosed subject matter in a pre-injection stage, shown without the plunger for purpose of y. is a cross-sectional side view taken along line B-B of . is a front view of the syringe housing assembly of during an initial stage of operation with the stepped shroud depressed against an injection site. is a cross-sectional side view taken along line B-B of . is a front view of the syringe housing assembly of at the end of the injection stage with the stepped shroud pressed against the injection site. is a sectional side view taken along line B-B of . is a front view of the syringe housing assembly of in a post-injection stage with the shroud ed. is a cross-sectional side view taken along line B-B of . 11048261_1:hxa is a front view of an automatic injection device similar to that of but having a bulbous housing and showing the device in the post-injection stage with the indicator visible in the window. is an exploded perspective view of an embodiment of an tic injection device according to one embodiment of the disclosed subject matter. is an exploded perspective view of an embodiment of the firing mechanism ly of the automatic injection device of according to an illustrative embodiment of the disclosed subject .

A is a perspective view of an embodiment of the activation button cap of the firing mechanism assembly of 11048261_1:hxa W0 44172 PCT/U52012/056756 B is a cross~sectionai side View of the activation button cap of A. 1A is a perspective View of an embodiment of the firing body of the firing mechanism assembly of 18 is a front View of the firing body of 1A.

A is a perspective View of an embodiment of the plunger of the firing mechanism assembly of B is a from, View of the plunger of A.

FIG. IZC is a detail View of region C of 3. is an exploded perspective View ofan embodiment of the syringe housing assembly ofthe automatic injection device of according to an illustrative embodiment of the sed subject matter.

A is a pempectfive View of an embodiment of the syringe carrier of the syringe g assemny of .

B is an exploded view from a different perspective of the syringe carrier of A, including an exemplary damping structure according to an illustrative embodiment of the disclosed subject matter. 0 is a front view ofthe e carrier of A.

FIG. MD is a side View of the syringe r of A.

FIG. MB is a cross-sectional side View taken along line E—E of 3.

F is a cross—sectional front view taken along line F-F of D.

G is a cross—sectional top View taken along line G-G of 14B.

H is a cross-sectional side View taken along line H—H at a bottom portion of G. ! is a bottom View of the syringe carrier damper of B. } is a cross-sectional side View of the e housing assembly of rating further details of the interaction between the syringe carrier of A and the housing.

K is a detail View of region K of FIG. l4J.

PCTfU32012/056756 L is a eross‘sectional side View of the syringe housing assembly of illustrating further s ofthe interaction between the syringe carrier of A and the housing.

FIG. MM is a detail View of region M of the L.

FIG. MN is a cross-sectional side View of the syringe g assembly of illustrating r details of the interaction between the syringe carrier of A and the housing. 0 is a detail View ofregion 0 of N. ]3 is a crossrsectional side View ofthe syringe housing IO assembly of FIG. l3 illustrating further details of the ction between the syringe r of A and the housing. 0 is a detail View of region Q of FIG. l4P.

R is a front View of the syringe carrier of A, for purpose of comparison. 3 is a front View of an alternative embodiment of a syringe carrier for the automatic injection device of in accordance with the disclosed subject matter.

FIG. MT is a from View of a r embodiment of a syringe carrier for the automatic injection device of in accordance with the sed subject matter.

A is a perspective View ofan embodiment of the housing of the syringe housing assembly of . 8 is a front View of the housing of A.

C is a top View of the housing of A.

D is a cross—sectional from view of the housing of FIG. ISA.

A is an embodiment of the stepped shroud of the syringe housing assembly of , B is a front View of the stepped shroud of A.

A is a perspective View of an embodiment of the needle shroud cap of the syringe housing assembly of .

B is a cross-sectional front View of the needle shroud cap of A.

FIG. NC is a top View of the needle shroud cap of A.

D is a ewes-sectional side View of the needle shroud cap taken along line DB of C.

A is a front View ofan ment of the syringe housing assembly of according to an illustrative embodiment of the disclosed subject matter.

FIG .383 is a sectional side View taken along line B-B of A. is a from View of a further embodiment of the syringe housing assembly ofaccording to an illustrative embodiment of the disclosed t matter.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT: Reference will now be made in detail to the various exemplary embodiments of the disclosed subject matter, exemplary embodiments of which are illustrated in the accompanying drawings. The structure and corresponding method of operation of the disclosed subject matter will be described in conjunction with the detailed description of the system.

The apparatus and methods presented herein can be used for injecting any of a variety of suitable therapeutic agents or substances, such as a drug, into a patient. In one embodiment, the automatic injection device can be configured in the form of a pen, i.e., an autoinjector pen or autoinjection pen (used interchangeably herein). As used herein, an “automatic ion device” or “autoinjector” (used interchangeably herein) is intended to refer generally to a device that enables an dual (also referred to herein as a user or a patient) to self—administer a dosage of a liquid nce, such as a eutic agent, including a formulation in liquid form, wherein the device differs from a standard syringe by the inclusion of a mechanism for tically delivering the medicaticm to the dual by ion when the mechanism is activated. In some embodiments, the liquid therapeutic agent can include one or more biological agents, such as a protein. For e and without limitation, one such liquid therapeutic agent can be 3 INF inhibitor, such as adalimumab. Additional details regarding possible therapeutic , including adalimumab, are provided in US. Patent Application Serial No. 12f074,704, the contents of which are incorporated by reference herein in its entirety.

PCT/U52012/056756 in accordance with the disclosed subject matter herein, the automatic injection device generally includes a housing, a syringe, a plunger, and a syringe r, The housing includes a first end, a second end, and a barrel between the first end and the second end. The barrel includes an elongated window to allow viewing of contents inside the housing. The syringe is disposod within the housing and has a first end, a second end, and a reservoir between the first end and the second end. The plunger is at least partially disposed within the syringe and includes a visual indicator on a portion of the plunger. The syringe carrier is disposed within the housing and configured to contain the syringe and displace the syringe within the housing between a first on and a second position. The automatic injection device can also include a cap, having an outer portion and an inner portion, and a shroud.

The syringe carrier can be substantially transparent. Additionally or alternatively, the syringe carrier can r have one or more openings configured to align with the window and the reservoir when the syringe carrier is in the first position, and/or to align with the window and the visual indicator when the syringe carrier is in the second position. Additionally, if transParent, the syringe carrier can have first and second legs and an extension disposed etween, and at least a n of the extension can be configured to align with the window and the reservoir when the syringe carrier is in the first position.

The accompanying figures, where like reference numerals refer to cal or ninetionally similar elements throughout the separate views, serve to r illustrate various embodiments and to explain various principles and advantages all in accordance with the disclosed subject matter. For purpose of explanation and illustration, and not limitation, exemplary ments of the automatic ion device in accordance with the disclosed subject matter are shown in FIGS. lA-19. While the present disclosed subject matter is bed with respect to using the device to provide a subcutaneous injection of a dose of a TNF inhibitor, one skilled in the art will recognize that the disclosed subject matter is not limited to the illustrative embodiment, and that the injection device can be used to inject any suitable nce into a user. In on, the components and the method of using the automatic injection device are not limited to the illustrative embodiments described or ed herein.

Generally, and unless otherwise noted, the term "first end" refers to the portion or end of an automatic injection device or ent in the automatic injection device to be disposed or positioned at or near to an injection site when the device is held against a person for an injection or for mimicking an injection. The term “second end” refers to the portion or end of an tic ion device or a ent of the automatic injection device spaced from an injection site during an injection. ing to an illustrative embodiment of FIGS. 1A-1B and 2, an automatic injection device 10 includes a housing 12, at least for housing a container, such as a syringe or cartridge, containing a dose of a substance to be injected into a patient. As described further below, the housing 12 embodied herein includes a first housing component 12a for housing a syringe housing assembly 121 and a second housing component, for example, a firing body 12b for housing a firing ism assembly 122. The housing 12 generally has a r uration, though one skilled in the art will ize that the housing 12 can have any number of suitable shapes and configurations for housing a syringe or other container of a substance to be ed. While the sed t matter will be described with respect to a syringe mounted in the housing 12, one skilled in the art will recognize that the automatic injection device 10 can employ other suitable containers for storing and dispensing a substance.

For example, the container for storing and dispensing a substance can be a cartridge.

Additionally, the container, whether a syringe 12 or cartridge, can be made of glass, a polymer, or a variety of other suitable materials for storing and dispensing a substance. ing to FIGS. 1A-1B, the syringe is preferably slidably mounted in the housing 12, as described in detail below. In an inactivated position, the syringe is sheathed and retracted within the housing 12. When the device is actuated, the syringe is extended such that a needle of the syringe ts from a first end 20 of the housing 12 to allow on of a substance from the e into a patient. As shown, the first end of the housing 20 includes an opening 28 through which the needle of the syringe projects during actuation of the device 10.

Continuing to refer to FIGS. 1A-1B and 2, a firing mechanism assembly 122 is disposed in housing 12 and includes an activation button 32, exposed through a second end 30 of the housing 12, for actuating the syringe to move from the sheathed position within the housing 12 to a projecting position with the needle projecting from the housing and/or expel the substance from the syringe needle into the patient. The housing 12 can house one or more actuators to perform the function of moving the syringe and expelling the substance from the syringe. 11048261_1:hxa W0 20131044172 PCT/U52012/056756 The illustrative automatic injection device 10 shown in FIGS. lA—lB, 2 can also include a needle shroud cap 24, as shown for example in FIGS. l7A-17D, to cover the first end 20 of the g 12, and thus t re of or access to the needle in the syringe prior to use. In the illustrative embodiment, the needle shroud cap 24 can include a boss or hub 26 for locking and/or covering the interior components ofthe device 10 until the user is ready to activate the device 10.

Alternatively, the needle shroud cap 24 can se a threaded screw portion and the first end 20 ofthe housing 12 at opening 28 can comprise mating screw thread. ative suitable mating or coupling mechanisms can be used in accordance with IO the teachings of the disclosed subject matter. As shown for example in FIGS. 10A— 10B and discussed further below, an actuator cap 34 can. also be provided to cover the secoud end 30 of the housing 12 and thus prevent accidental actuation of the activation button 32.

In the illustrative embodiment ofFIGS. lA—lB and 2, and with reference to FIGS. B and ”AND, the housing 12 and caps 24 and 34 can r e graphics, symbols and/or s to facilitate use of the automatic injection device 10. For example, the housing 12 can include an arrow or other a on an outer surface pointing towards the first end 20 ofthe device to indicate the direction in which the device 10 should be held relative to the injection site. In addition, the needle shroud cap 24 can be labeled with a "l " to indicate that a user should first remove the needie shroud cap 24 of the device first, and the actuator cap 34 can be labeled with a ”2" to indicate that the actuator cap 34 should be d second after the needle shroud cap 24 is removed during ation for and subsequent injection using the illustrative automatic injection device 10. Furthermore, either or both caps 24, 34 can be labeled with one or more arrows indicating the direction of removal. Additionally, the needle shroud cap 24 can be a different color than actuator cap 34, and labels, such as numbers and/or arrows can be accented with a highlighted or contrasting color from the corresponding cap 24, 34, such as white, to allow the user to more easily identify the caps 24, 34 and understand the sequence of removal of caps 24, 34 for preparation of the device 10. Further, the needle shroud cap 24 and/or the actuator cap 34 can include one or more contours or indentations 23, sized and shaped to facilitate gripping and removal of the caps 24, 34 by the user.

One skilled in the art will recognize that the automatic injection device 10 can have additional or alternative suitable graphics, symbols and/or numbers to facilitate user PCT/U52012/056756 instruction, or the automatic injection device can omit such graphics, symbols andfor numbers.

As rated in F168. lA~lB and 2, the housing 12 embodied herein includes at least one ted window 130 to allow a user to View the contents of the syringe housed within the housing 12, as described in detail below. The window 130 can comprise an opening in the sidewall of the housing 12, and/or can se a ucent or transparent material in the housing 12 to allow viewing of the interior of the device 10. A second Window can be ed diametrically opposite the first window to allow viewing through the housing and syringe if desired. Additional or alternative window embodiments likewise can be ed, for example and as further described below, wherein the window 130 is sufficient in length to function as described herein.

The housing 12 can be formed ofany suitable surgical or medical device material, including, but not limited to, plastic and other known materials.

As previously noted and described in further detail below, the automatic injection device 10 disclosed herein generally comprises two components, a syringe housing assembly 121 and a firing mechanism assembly 122. For purpose of illustration and not limitation, reference is first made to the sequence of operation of the tic injection device 10, and particularly to the operation of the syringe housing assembly 121 of the disclosed subject matter.

FIGS. 3A-6B are front and cross-sectional side views of interior cornponents of a syringe housing assembly 121 for an automatic ion device 10 according to one embodiment of the disclosed subject matter. As shown, a syringe 50 or other suitable container for a nce is disposed within the interior of the housing 12. The illustrative syringe 50 es a hollow barrel portion 53 for holding a dose of a liquid substance to be injected. The rative barrel portion 53 is substantially cylindrical in shape, though one skilled in the art will ize that the barrel portion 53 can have a variety of suitable shapes or configurations. A seal, illustrated as a bung 54, substantially seals the liquid substance within the barrel portion 53. The syringe 50 can further include a hollow needle 55 connected to and in fluid communication with the barrel portion 53, through which the dose of liquid substance can be ejected by applying pressure to the bung 54. The hollow needle 55 s from a first end 53a of the barrel portion 53. The second end 53b of the barrel portion 53 can include a flange 56, or other suitable mechanism, for abutting a stop, represented schematically as 123, in the housing 12 to limit the movement of the syringe 50 within the housing 12, as described below. One skilled in the art will recognize that the disclosed subject matter is not limited to the illustrative embodiment of the syringe 50 and that other suitable containers for containing a dose of a substance to be injected can be used in accordance with the disclosed subject matter. In the illustrative embodiment of FIGS. 3A-6B, the needle 55 can be a fixed twenty-seven gauge one-half inch needle. The tip of the illustrative hollow needle 55 can include five bevels to facilitate insertion. However, the needle 55 can have any size, shape and configuration suitable for the intended use as known in the art and is not d to the illustrative embodiment. The automatic injection device 10 further includes a syringe actuation ent to selectively move and/or e the syringe 50 to inject the dose of liquid substance ned in the syringe 50 into a user. As embodied herein, the syringe actuation component 700 is a plunger (shown in and forms a part of the firing ism assembly 122. The syringe actuation component 700 can further have an indicator 190 (shown in to indicate tion of the ion, as discussed below.

FIGS. 3A-6B illustrate the syringe housing assembly 121 in various stages of operation.

In a jection position, as shown in , the e 50 is in a sheathed position within the g 12. The needle shroud cap 24 is disposed on the first end 20 of the housing 12 to prevent access to or exposure of the needle 55. As evident from , the contents of the syringe 50 are visible through the window 130. FIGS. 4A-4B illustrate the syringe housing assembly 121 in an initial stage of deployment, showing a transition between the pre-injection position and the post-injection position. At this initial stage, the stepped shroud 12d is depressed against the injection site, and the syringe carrier 500 has moved relative the window 130 toward the first end 20 of the housing 12. FIGS. 5A-5B show the syringe housing assembly 121 at the end of the injection stage with the stepped shroud 12d still depressed against the ion site, such that the needle 55 is extending from the housing 12 into the injection site. Upon completion of the stroke or nt of the syringe 50, the contents of the syringe 50 are no longer visible through the window 130. As described herein, however, the indicator 190 on the plunger or actuation component 700 will then be visible for indication that injection is complete and that the device 10 can be removed from the injection site. FIGS. 6A-6B show the syringe g assembly 121 in the post-injection position, with the device 10 removed from the injection site g the stepped shroud 12d to , as further described below. As bed herein, the indicator 190 on the plunger or actuation component 700 remains visible to indicate that the device has been deployed. 11048261_1:hxa As previously noted, and with reference to the automatic injection device 10 can comprise two interlocking components: a syringe housing assembly 121 and a firing mechanism assembly 122. The syringe housing assembly 121 and the firing mechanism assembly 122 can be coupled through any suitable means. In the illustrative embodiment, a first end 122a of the firing mechanism assembly 122 can be sized and configured to be inserted into a second end 121b of the syringe housing assembly 121. In addition, one or more tabs 127 on the first end 122a of the firing mechanism assembly 122 can snap-fit into corresponding openings 126 on the second end 121b of the syringe housing assembly 122 to ensure alignment and coupling of the two assemblies 121, 122 and the components housed therein. is an ed view of the firing mechanism assembly 122, for illustration and not limitation, ing to a entative embodiment of the disclosed subject matter. As shown, the firing mechanism assembly 122 includes an tion button 32, a second removable cap, for example, the actuator cap 34, firing body 12b and a coil spring 88 or other biasing ism. The illustrative firing mechanism assembly 122 further includes a syringe or, such as a syringe actuation component 700, that s from the first end 122a of the firing body 12b. As embodied herein, the syringe actuation component 700 can be configured to move the e 50 in a first phase and actuate the syringe 50 to expel its ts in a second phase.

FIGS. 10A-10B illustrate the actuator cap 34 according to illustrative ments of the disclosed subject matter. The actuator cap 34 can include a locking pin 36 to engage the activation button 32 and prevent inadvertent actuation of the activation button 32 before actuator cap 34 is removed. The actuator cap 34 can be mounted on the housing in a variety of ways. For example, and as shown in the second end of the housing 12 can be provided with a diameter smaller than the an adjacent section of the housing. A step 29 can be formed at the transition between the two diameters to facilitate seating of the actuator cap 34 on the second end 30 of the housing.

The actuator cap 34 can have a ctive color to entiate the first end 20 and second end 30 of the device, though one skilled in the art will recognize that the actuator cap 34 and housing 12 can have any suitable color, size and configuration. 11048261_1:hxa As shown in FIGS. 1A-1B and 10A-12B, the firing body 12b includes a substantially tubular body, which can include taper and/or contours 128 to facilitate gripping of the device 10 by a user. A step 29 can be formed in a distal , for example, a second end 30 to facilitate seating of the actuator cap 34, as bed above. Additionally, a mating feature can be provided to secure the or cap 34 to the firing body 12b. For example, and as depicted in mating tabs 33 on the firing body 12b can be configured to be received within receptacles 22 of actuator cap 34, for example by an engagement or snap-fit or the like, and thus lock the actuator cap 34 to the firing body 12b and activation button 32 and prevent inadvertent removal of the actuator cap 34. Mating tabs 33 can also align actuator cap 34 with the housing 12 during assembly and prevent rotation of the actuator cap 34 relative to the firing body 12b during transportation or handling of the device 10, which can prevent accidental firing of the device 10. As embodied herein, the mating tabs 33 and corresponding receptacles 22 can have a petal shape, although other configurations can be used. Forward of the step 29, the firing body 12b has a size and shape configured to be inserted into the distal end of the syringe housing 121. Tabs 127 are formed to facilitate ng and/or locking of the two housing components 12a and 12b together. As shown in FIGS. 11A-11B, the tabs 127 can be formed in a depression 127a on the surface of the proximate end of the firing body 12b, and can also or alternatively include ribs 127b for guiding the tabs into a locking on relative to the proximate housing ent 12a. One skilled in the art will recognize that any suitable means for coupling the two lies together can be used and that the invention is not limited to the illustrative coupling means.

As shown in FIGS. 11A-11B, the firing body 12b can include an anchoring cap 12c coupled to a smaller diameter distal end of the firing body 12b for ing the firing mechanisms for actuating the device 10 to the firing body 12b. The ace of the anchoring cap 12 c and the firing body 12b can form a groove 1234 to facilitate a snap fit of the activation button 32 on the distal end of the firing body 12b, or can be joined by other suitable joining means as described above.

Referring to FIGS. 3B and C, the syringe actuation ent 700 can be an integrated component formed of any suitable material, such as an acetal-based plastic, though other le materials can also be used. The syringe actuation component 700 comprises a pressurizing end, for example, pressurizer 754 for applying pressure to the bung 54 of a corresponding syringe 50, and a plunger rod portion 70 with a compressible expanded l 11048261_1:hxa portion, illustrated as the plunger elbows 78. onal components, such as components for anchoring the coil spring 88 to the syringe actuation ent 700, can also be provided as described below. The compressible expanded central portion 76 facilitates movement of a ponding syringe 50 toward the injection site and expulsion of the contents of the syringe 50 in two separate steps, as described above. Alternatively, the syringe actuator can comprise multiple actuators for moving and/or promoting expulsion of the syringe 50.

The syringe actuation component 700 of FIGS. 3B and 12A-12C can further include an indicator 190 in a solid rod portion 70 distal from the elbows 78. During operation of the device 10 and after completion of an injection, the indicator 190 is configured to align with the window 130 on the housing 12 to te tion of the ion. The indicator 190 preferably has a distinctive color or design to represent completion of an ion.

As shown in FIGS. 1B, 8 and 12A-12C, the illustrative syringe actuation component 700 further includes a retaining flange 720 for holding the actuating coil spring 88 in a compressed position until actuation. The retaining flange 720 is sized, dimensioned and formed of a material that preferably allows the syringe actuation component 700 to slidably and easily move within the housing 12 when the device 10 is actuated. Extending distally from the retaining flange 720, the syringe actuation component 700 forms a base 788 for the ing coil spring 88. The base 788 terminates in a trigger anchoring portion 789. For example, and as depicted herein, the illustrative base 788 can comprise flexible legs 788a, 788b around which the spring 88 is disposed. The trigger anchoring portion 789 can comprise tabbed feet 7891 ing from the base 788 and configured to selectively engage the anchoring cap 12c and/or firing body 12b.

The tabbed feet 7891 can include one or more angled surfaces to define a cam or the like. For example, and as shown in C, the tabbed feet 7891 can have a substantially arcuate shape formed by multiple edge segments, each having a different angle relative to the length of the base 788. As embodied , for purpose of illustration and not limitation, from the end of the tabbed feet 7891 s the base 788, the edge segments can have successively decreasing angles α, β, γ of 82°, 45° and 23°, respectively. The tion button 32 coupled to the distal end of the firing body 12b is configured to hold the trigger 11048261_1:hxa PCT/USZOIZ/056756 anchoring portion 789 until activation. When activated, the activation button 32 es the trigger anchoring portion 789, allowing the spring 38 to urge the syringe actuation component 700 toward the proximal end 20 of the device 10 in an operation described above.

In a retracted, anchored position shown FIGS. IB, BB and 12A-12C, the trigger ing portion 789 interacts with the housing 12, which holds the tabbed feet 789i in a latched position, against the biasing force of the coil spring 88, to maintain the e actuation component 700 in a retracted position. in this position, the flange 720 retracts the Spring 88 against the back, distal wall 712 of the firing body 12b. An opening 7 l 3 in the anchoring cap 120 allows the tion button 32 access to the anchoring portion 789. In the retracted position, the preSSurizer 754 of the syringe ion component 700 extends out of an opening 228 on the proximal end 122a of the firing body 12b. When the firing body 12b couples to a ponding syringe actuation ism 121, the pressurize: 754 extends into the barrel portion of a syringe housed therein. The pressurizer 754 can be integral with, the same as, connected to, or otherwise in communication with the bung 54 of a syringe 50 housed in the device 10 and can be provided with any le size, shape and ration suitable for applying pressure to the bung 54. in one embodiment, the pressurizer 754 has a cross-section corresponding to the shape of the barrel portion 53 of a corresponding syringe 50 so as to substantially seal the barrel portion 53, and the pressurizer 754 is configured to slidably move within the barrel portion 53 to apply pressure to the bung 54 and e the syringe 50.

In the illustrative embodiment of the syringe actuation component 700 constitutes a , integrated mechanism for anchoring a corresponding syringe 50, spring 88 and other components, actuating and moving the syringe 50 to an extended position, and expelling the contents of the syringe 50.

Additional details of the iilustrative firing mechaniSm assembly 122 and related s of the automatic injection device to are provided in US. Patent Application Serial No. 12/074,704, which is incorporated by reference herein in its entirety. is an exploded view of the syringe housing assembly 121 ofan rative embodiment of the disclosed subject matter, which for purpose of example and not limitation is configured to couple to and interact with the firing mechanism ly 122 of The illustrative syringe housing assembly 121 includes a housing component 12a, a needle shroud cap 24, a biasing mechanism 89, a syringe PCT/U52012/056756 carrier 500, and a stepped shroud 12d at the first end 20 of the housing 12 when led and includes the first opening 28, as also shown in The components 123, 12d, 89, 500 and 24 cooperate to house a syringe 50 containing a substance to be injected and facilitate operation of the device 10 as desaibed above. Additional details of the illustrative syringe housing ly 121, firing mechanism assembly 122 and related aspects of 1the automatic injection device 10 are provided in U.S.

Patent Application Serial Nos. 13/443,384; 12/968,744; 12/770,557 and l2/074,704 and US. Patent Nos. 8,162,887; 7,938,802; 7,229,432 and 6,805,686, each ofwhich is incorporated by reference herein in its entirety.

Illustrative ments of the syringe carrier 500, housing 12, the d shroud 12d and the needle shroud cap 24 are shown in detail in FIGS. 14A- l4Q, ISA-15D, l6A-16B and 17A-17D, respectively. FIGS. 18A and 188 are a perspective side View and a cross-sectional side View, reSpectiver, of the assembled spring g assembly 121 according to one embodiment ofthe sed subject . One skilled in the art will ize that the disclosed subject matter is not limited to the illustrative embodiments only.

Referring now to FIGS. lA-lB, 2, 13, l4A—14Q, and 18A—18B, the syringe carrier 500 of the illustrative embodiment holds or contains at least a n of a syringe 50 used in the device 10. The syringe 50- rests in the carrier 500, which in turn is contained in the housing 12. During operation, the syringe 50 and carrier 500 move forward (cg, towards the first end 20 proximate the injection site) within the housing 12. The housing 12 is configured to limit the movement of the carrier 500 beyond the first end 20, and the carrier 500 in turn limits the movement of the syringe 50. The syringe carrier 500 embodied herein has a substantially tubular structure including at least a first opening 505 proximate the first end of the carrier 500 and a sec0nd g 501 space from the first end ofthe carrier 500.

In accordance with another aspect of the disclosed subject matter, and with reference to the ment of FIGS. l4A-14l, the first opening 505 can be defined by legs 506 extending from a middle portion 507 disposed between the first opening 505 and the second opening 501. In the led state, the first opening 505 is located closer to the first end of the housing 12a than the second opening 501. The middle portion 507 is sized and configured to provide suitable strength to the syringe carrier 500 to prevent ng or ation of the syringe carrier 500 during operation of the device. rmore, additional openings can be provided to correspond with the window 130 or windows of the housing. For e, for either or both of the first g 505 or second opening 501, a front opening can be provided diametrically opposite a rear opening to allow viewing through the syringe carrier 500.

For example, an as illustrated in FIGS. 14A-14Q, the legs 506 embodied herein each also include an anchor portion 503 at a first end of each leg 506. The anchor portion 503 of each leg 506 includes a first projection 508 and a second tion 509 to define a generally radial . In the rative embodiment, in the pre-injection position, the first and second projections 508, 509 engage an interior stop 256 within the radial groove, as shown in FIGS. 15C-15D and 18B. The first projection 508 can be larger than second projection 509 and sized to prevent movement of the first projection 508 past the interior stop 256, thus preventing movement of the syringe carrier away from the injection site.

As shown in FIGS. 14J-14Q, the second projection 509 can be configured to pass the interior stop 256 when the syringe carrier 500 is urged toward the injection site, as described below. The second tion 509 can be configured such that the additional force to move the second projection 509 past the interior stop 256 can be less than the force to advance the syringe actuation component 700 within the syringe, and thus prevent advancement of the e actuation component 700 and expulsion of the syringe contents before the syringe 50 and needle 55 are moved to the ion site. For example, and as embodied , the surface of second projection 509 can be substantially arcuate or include an e portion configured to abut the interior stop 256, and interior stop 256 can include a chamfered edge n configured to abut the second projection 509 to reduce the amount of force to urge the second projection 509 past the interior stop 259. Additionally or alternatively, legs 506 can act as a living hinge, which can provide for easier assembly of the syringe carrier 500 into the syringe g assembly 121 and also allow the syringe carrier 500 to move past the interior 259.

Additionally, for purpose of illustration and not limitation, and as embodied herein, syringe carrier 500 can be configured with two pairs of legs 506 distributed substantially symmetrically about the barrel of the syringe carrier 500, which can provide substantially even distribution of the force applied to the syringe carrier legs 506 when engaging interior stops 256 of the housing 12, and thus prevent damage to legs 506 during assembly, transportation or handling. Further, force can be distributed substantially evenly to each leg 506 when a force is applied to the syringe 11048261_1:hxa carrier 500 to move the second projection 509 of each leg 506 past each interior stop 256 of the housing 12, In this manner: the legs 506 can be released from the housing 12 at substantially the same time for improved activation, ing, for example, when syringe 50 is tilted and contacts the syringe carrier 500 at the start of the device activatiori and firing.

A syringe carrier coupler 504, formed as two beams extending fitom the middle portion 507, s forward beyond the anchor portion 503 to tate coupling of the syringe carrier 500 with an end of the spring 89 and/or the stepped shroud 12d.

The legs 506 are sized and shaped for added durability and strength.

For example, either or both of the first and second projections 508, 509 of legs 506 can be wedge~shaped and have a thickness to provided added strength. Additionally, the legs 506 can be tapered for greater width or thickness proximate the middle portion 507, and/or the legs 506 can be angled ly radially outward relative a longitudinal axis ofthe syringe carrier 500 to more securely engage the interior stop 256. in accordance with another aspect, the syringe carrier 500 can be made of a transparent material to allow the contents of the syringe 50 to be visible therethrough. For example, the syringe carrier 500 in its entirety can be made of a transparent material, or only a selected portion or portions can be made oftransparent material. For example, an axial n of the e carrier 500 in alignment with the window 130 ofthe housing 12 can be made of transparent material, whereas the remainder of the syringe carrier 500 can be opaque. onally or alternatively, the syringe carrier 500 can have one or more gs or windows having various configurations to r allow viewing of the ts of the syringe 50 and/or an indicator 190 through the syringe carrier 500. For e, as shown in FIGS. 14A- l4R, the syringe r 500 embodied therein has a substantially tubular structure including at least a first opening 505 proximate the first end of the carrier 500 and a second opening 501 spaced from the first end of the carrier 500. Such an embodiment can be beneficial, for example, for use with a syringe 50 having a 0.4 mL dose of a liquid therapeutic agent to allow viewing of the entire close when the e carrier 500 is in the first position.

For purpose of comparison, $ depicts an alternative syringe carrier 500 embodiment having a substantially tubular structure including at least a PCTIU52012/056756 first opening 505 proximate the first end of the carrier 500 and a second opening 501. space from the first end of the carrier 500. In contrast to the syringe carrier 500 of R, the first opening 505 is a larger opening, extending toward and into the middle portion 507 ofthe syringe carrier 500. Such an embodiment can be ial, for example, for use with a syringe 50 having a large volume, such as a 0.8 mL dose of a liquid therapeutic agent, to allow viewing of the entire close when 1the e carrier 500 is in the first position.

In operation, in the pro-injection position, the first opening 505 of the syringe carrier 500 ofFiG. 148 in the first position is aligned with the window 130, the cap notch 250, and the shroud notch 115. This alignment allows Viewing of the syringe barrel 53 through the window l30 to permit viewing of the contents of the syringe 50. In this configuration, substantially none of the syringe carrier 500 is aligned with the Window in the pro—injection configuration. in the post-injection position, the second opening 501 of the syringe carrier 500 is in the second position and aligned with the window 130 and the indicator 190 of the syringe actuation component 700 to indicate that the injectiOn is ted. With the shroud 12d deployed, the second opening 501 oftne syringe r 500 in the second position remains aligned with the window 130 and the te: 190 of the syringe actuation component 700 to indicate that the device 10 has been deployed. in accordance with another aspect of the disclosed subject matter, and as ed in ’1", a further syringe carrier 500 embodiment has a substantially tubular structure without the openings of the embodiments of FIGS. 14R and 148.

Rather, since the e carrier 500 is transparent, the user can View the contents of the e 50 and the indicator 190 through the syringe carrier 500 material. Similar to the embodiments of FIGS. 14R and 148, legs 506 extend from the middle portion 507 and have similar operation, as described . However, rather than defining an opening therebetween, an extension 510 is defined or formed between the legs 506.

Additionally, the legs 506, as well as extension 510, can be sized and shaped for added durability and th. For example, either or both of the first and second projections 508, 509 of legs 506 and/or ion 510 can be wedge—shaped and have a thickness to provided added strength. Additionally, the legs 506 and/or extension 510 can be tapered for greater width or thickness proximate the middle n 507, and/or the legs 506 can be angled slightly radially outward relative a longitudinal axis of the syringe r 500 to more securely engage the interior stop 256. The extension PCT/U52012/056756 510 is disposed so as to be aligned with the window 130 of the housing 12 during operation. As depicted herein, the extension 510 has a substantially smooth outer surface to minimize any d or free edges within the window 130. Further, the extension 510 can provide an underlying cover for window 130, ng the ts of the device 10 to be protected without utilizing a separate cover member.

In operation, at least a portion of the extension 5 10 ofthe syringe carrier 500 ofFlG. 14'1“ in the first position is aligned with the window 130, the cap notch 250, and the shroud notch, 115. This alignment allows viewing ofthe syringe barrel 53 through the extension 510 and window 130 to permit viewing of the contents of the syringe 50. Further, the extension 510 can provide an underlying cover for window 130, allowing the contents of the device 10 to be protected without utilizing a separate cover member. The portion of the ion 510 aligned with the window 130 can include a fill line to indicate a desired fill level of the syringe contents and/or can include a logo, symbol or other indicia to be visible to the user through window 130 in the pro-injection position- In the post—injection position, a transparent wall 511 of the syringe carrier 500 is in the second position and aligned with the window 130 and the indicator 190 of the syringe actuation component 700 to indicate that the injection is completed. Alternatively, syringe carrier 500 can include an opening, similar to the second g 501 of the syringe carrier 500 of FIGS. 14R and 148, through which a user can View the tor 190. With the shroud 12d deployed, the second opening 501 of the syringe carrier 500 in the second position remains aligned with the window 130 and the indicator 190 of the syringe actuation component 700 to te that the device 10 has been deployed.

Furthermore, and as shown in FIGS. l4A-14Q, the syringe r 500 can include a flanged second end 562 configured to interface with a flanged second end 56 (shown in B) of the e 50. The d second end 562 can serve as a damper for the syringe 50. Additionally, the flanged second end 562 can include a damping structure 564, such as an elastometic member mounted on or formed integrally with the second end 562 of the syringe carrier 500. The syringe carrier 500 can r include one or more intermediate flanges 563, which in the illustrative embodiment forms a stop for the syringe 50 to interact with an interior stop 256 on the housing component 12a to limit forward motion of the syringe 50.

As ed herein, the syringe carrier 500 is slidably diSposed within the housing 12 and selectively carries the syringe 50 within the housing 12. “22..

PCT/U82012/056756 Alternatively, the syringe carrier 500 can be stationary within the housing 12 and configured to allow the syringe 50 to selectively and controllably slide within and relative to the syringe r 500. The syringe carrier 500 can have other suitable configurations and sizes for carrying or guiding the syringe 50 within the g 12.

Referring to FIGS. 16A-16B and 188, the illustrative stepped shroud 12d is disposed at the first end 20 of the housing 12. The illustrative stepped shroud 12d has a substantially tubular body, ing a hub 112 defining the opening 28 at the first end 20 of the device 10, through which the syringe needle 55 can t during operation of the device 10. A step 113 from the main tubular body portion 1 16 forms the hub 1 12 of smaller diameter than the main tubular body portion 116 of the stepped shroud 12d. As shown in B, the step 113 fonns a forward stop for the spring 89 to confine the spring 89. In the illustrative embodiment, shown in FIGS. 16A-168 and 1813, a shroud notch 115 is formed in a rim at the second end of the stepped shroud 12d. The rim of the stepped shroud 12d abuts the first side of the stop 256 of the housing component 12a. The shroud notch 115 can align with. a portion of the window 130 to prevent ction of the window 130. Additionally, arms 114 extend from the stepped shroud 12d to lock in the stepped shroud 12d to prevent ntal needle sticks. The stepped shroud 12d can further include a guide, such as a groove and/or slot 118 as shown in FIGS. 16A—168 to receive pouding projections or keys 257, as shown in FIGS. 1501513, and thus allow for coaxiai movement ofthe stepped shroud 12d and the syringe carrier 500 without rotation relative the housing 12. The configuration and operation of the stepped shroud 12d is described further in US. Appiication Serial No. ,704, and US. Patent Nos 7,229,432 and 6,805,686, each ofwhich is incorporated by reference herein in its entirety.

Referring again to FIGS, 14A-16B and 18B and to the stages of operation of the device shown in FIGS. 3A~6B, with the device in the pro—injection position, the cap 24 is removed and the stepped shroud 12d is depressed against the injection site and thus ted within the housing 12. Upon activation of the firing assembly mechanism 121, the syringe r 500 is urged forward, toward the first end of the device 10, and the legs 506 deflect radially outward causing the anchor portions 503 to disengage from the stop 256 to allow the syringe carrier 500 to move d. As the e carrier 500 is urged forward, beams of the syringe carrier coupler 504 compress spring 89 and engage the second end of stepped shroud 12d.

After syringe ion component 700 is fully ed, and completion of the injection is confirmed as bed below, the device 10 can be removed from the injection site. At this point, the device is in the post-injection position with stepped shroud 12 d extended beyond the needle 55 due to spring 89 and locked in the extended position by arms 114 abutting the stop 256.

Referring to FIGS. 17A-17D and 18A-18B, the interior of the rative needle shroud cap 24 can include a plurality of radial grooves 241, 243 for receiving protruding portions of the stepped shroud 12 d and the housing component 12a. For example, as rated in B, a first radially outer groove 241 receives a first end of the sidewall 242 of the housing component 12a. A second, radially inner groove 243 receives the first end of the hub 112 of the stepped shroud 12 d. The second end of needle shroud cap 24 includes a cap notch 250 to align with a portion of the window 130 to prevent obstruction of the window 130 when the needle shroud cap 24 receives the housing 12 (as best shown in FIGS. 3A-3B). The radial grooves 241, 243 can be ted by a radial inner wall 245, which can be formed as a ring, or alternatively can be formed as a plurality of arcuate wall portions.

The needle shroud cap 24 further includes a cap hub 26. Cap hub 26 is configured to extend into the inner lumen 1012 of the housing 12 and surround the first end of a syringe 50 loaded therein when the needle shroud cap 24 is coupled to the housing 12. The cap hub 26 can include two or more members, if desired, to define a hub opening 249. When the needle shroud cap 24 es the housing 12, the hub opening 249 can align with the at least a portion of the window 130 to prevent obstruction of the window by the cap hub 26.

Additionally, and as shown in B, a second end of the cap hub 26 can be configured with a reduced thickness to fit n syringe 50 and the first end of legs 506. In this manner, the legs 506 are radially deflected inward into engagement with the housing stop 256 to prevent premature deployment of the stepped shroud 12d when the cap 24 is d.

As embodied herein, a separate interior needle cover 246 (shown in B), such as a conventional rigid needle shield, sheaths the syringe needle 55. When the cap 24 is placed onto the housing 12, a circumferential ridge 247 can engage and secure the or needle cover 246 within the cap 24. When the cap 24 is removed, the syringe needle 55 is exposed within the lumen 1012 of the housing 12. The cap 24 can also include an opening in a first end 248 thereof. The cap 24 can further include one or more slots or apertures in a side thereof to allow for expansion 11048261_1:hxa PCTfU52012/056756 ofthe radial grooves 241, 243 or the hub 26 and/or to facilitate the needle cover 246 passing the circumferential ridge 247 when the cap 24 is placed onto the housing 12.

Referring again to the stages of operatien of the automatic injection device 10 shown in FIGS. 3A-6B, the alignment of the openings 50], 505 of the syringe canier 500 with the window 130 and other components of device 10 is described. In the pro-injection position shown in FIGS. 3A-6B, the first opening 505 ofthe syringe carrier 500 in the first position is aligned with the window 130, the cap notch 250, and the shroud notch l 15. This alignment allows viewing of the syringe barrel 53 through the window 130 to permit viewing of the contents of the syringe 50.

In the initially deployed position shown in FIGS. 4A—4B, the middle portion 507 of the syringe carrier 500 is visible in the window 130, along with portions of the first opening 505 and the second opening 501. The shroud notch 115 can be aligned with the window 130 ifthe shroud 12d is pressed against the injection site. This alignment can indicate that the device 10 is currently in operation. At the end of the injection, shown in FIGS. 5A~SB, the second opening 501 of the syringe carrier 500 is in the sec0nd position and aligned with the window 130 and the tor 190 of the syringe actuation component 700 to indicate that the injection is completed. The shroud notch l 15 can be d with the window 130 if the shroud 12d is d against the injection site. In the post injection cm, shown in FIGS. 6A—6B, with the shroud 2O 12d deployed, the second Opening 501 of the e carrier 500 in the secoud position remains aligned with the window 130 and the indicator 190 of the syringe actuation ent 700 to te that the device 10 has been deployed, as described further.

As described above and shown in A, openings 126 in the housing component 12a receive tabs 127 of the firing mechanism assembly 122 to tate assembly of the device 10. The window 130 described above for ng a user to View the contents of a syringe contained in the assembly 121, as well as to view an indicator 190 that fills the window 130 after completion ofan injection can be formed only in the first housing ent 12:: if sufficient length is available to function as described.

With nce now to the indicator 190, is a from View of the automatic injection device 10 of an embodiment of the sed subject matter, illustrating the syringe actuation component 700 according to one embodiment of the disclosed subject matter. The syringe actuation component 700 can form or otherwise include an indicator 190 visible through the window 130. The indicator 190 can be provided with a distinctive color, shape, and/or design to indicate to a user that an injection is complete.

The indicator 190 is configured to align with the window 130 of the housing 12 after the syringe actuation ent 700 completes an injection and fully or ntially fully expels the contents of the syringe 50 out of the needle 55 and into a patient. Thus, prior to operation of the device 10, the syringe barrel 53 aligns with the window 130 and the contents are viewable therein through the first opening 505 of the syringe carrier 500 in its first position. After ion, the syringe barrel portion 53 has moved towards the first end 20 of the device 10, such that the needle 55 protrudes from the first end 20 of the housing 12, and the syringe actuation component 700 has moved forward within the syringe barrel portion 53. In this position, the tor 190 is aligned with and visible in the window 130 through the second opening 501 of the syringe carrier 500 to indicate completion of an injection. Therefore, and in ance with this embodiment, even when the syringe 50 has moved into an exposed position with the needle 55 protruding from the housing 12, the indicator 190 will not align with the window 130 or otherwise indicate completion of an injection until the syringe actuation component 700 has expelled the contents of the syringe 50 out of the barrel 53.

Referring to FIGS. 15A-15D, the illustrative housing 12 includes a window 130 formed in a side wall of the housing 12 to allow a user to view the ts of the syringe prior to ion and to allow a user to view the indicator 190 after the device operation is completed.

As embodied herein, as shown in FIGS. 15A-15D, the illustrative window 130 preferably has an elongated shape of sufficient length for visibility of the first opening 505 of the syringe carrier 500 in the first position and the second opening 501 of the e carrier 500 in the second position. For example, the window 130 can have an oval shape with a first end 132 that is er than a second end 134, and the first end can align with a cap notch 250 when the cap 24 receives or is positioned in the housing 12. The second end 134 of the window 130 can be ntially semi-circular in shape and wider than the first end 132 of the window 130 for better visibility of tor 190, if provided. shows an alternate embodiment of device 10 with an alternative window 130 configuration. In contrast to the tapered or tear-drop configuration previously described, window 130 is generally oval-shaped. As shown in , the window 130 can have a substantially symmetrical oval shape or pill 11048261_1:hxa shape and can ably be configured as an open slot, or can alternatively be configured to include a transparent window cover to protect the contents of the device and allow viewing of the syringe contents therethrough, as well as to view an indicator 190 that fills the window 130 after completion of an injection. Further, the window 130 configuration of can be utilized with any of the embodiments of device 10 and syringe carrier 500 described herein. The window 130 can include a fill line 135 to allow verification of the proper dosage within the syringe.

The housing 12 can also include a beveled edge 136 surrounding the window 130. The beveled edge 136 can be used to e and secure an al shield 137. The shield 137 can be hingedly attached to cover the window 130, ifmade of an opaque material, or can be made of any le transparent material and secured to the housing 12 to allow the user to see through the shield 137. The shield 137 can also have properties to absorb or reflect, or otherwise prevent ultraviolet or other light wavelengths from entering the housing and damaging the contents of the syringe 50. For example, the shield 137 can include a transparent protective film with properties to block or absorb ultraviolet light, and the film can also include an adhesive layer for application to the shield 137 and/or to a pre~filled syringe.

Additionally or alternatively, a chemical having ultraviolet blocking or absorbing properties can be added to a arent resin to form the shield 137. The ultraviolet blocking or absorbing al can be added either by mpounding or tumble blending before molding the resin. As a further alternative, a transparent protective film or chemical having ultraviolet blocking or absorbing ties can be added to a product packaging for device 10 to further prevent degradation of the contents of the syringe 50.

The housing 32 can also include a portion 139 of increased strength proximate thelwindow 130. For example, and as depicted in the portion 139 can be provided with a non~cylindrical configuration, such as a bulbous or barrel- shaped n, for additional strength. The portion 139 of the housing 12 can be wider near the window 130 relative to the remainder ofthe g 12. The portion 139 can increase the strength and thus resist deformation of the g 12, which can otherwise be weakened by the loss of material in the housing 12 to form the Window 130, Additionally, the contoured housing can improve ergonomics and tics of the automatic injection device 10.

PCT/USZOlZ/056756 Although reference is made. to certain features on a front of the device or components, such as window 130, first and second openings 505, 501, shroud notch i 15 , cap notch 250, such features can include, for example, a corresponding, diametrically opposed feature on a rear of the device, or other suitable location on the device 10.

The automatic injection device of the disclosed subject matter can be used for ion or delivery of any of a variety of suitable liquid substances of corresponding voiume or dose.

While the disclosed t matter is described herein in terms of lO certain preferred embodiments, those skilled in the art will ize that various modifications and improvements can be made to the disclosed t matter without departing from the scope thereof. Moreover, although individual features of one embodiment ofthe discldsed subject matter can be discussed herein or shown in the drawings of the one embodiment and not in other embodiments, it should be apparent l5 that individual features of one embodiment can be combined with one or more features of r embodiment or features from a plurality of embodiments. in addition to the specific embodiments claimed below, the disclosed subject matter is also directed to other embodiments having any other possible combination of the dependent features claimed below and those disclosed above. As such, the particular features presented in the dependent claims and disclosed above can be combined with each other in other manners within the scope of the sed subject matter such that the disclosed subject matter should be recognized as also specifically directed to other embodiments having any other possible combinations.

Thus, the foregoing description of specific embodiments of the sed subject matter has been presented for es of illustration and description. It is not ed to be exhaustive or to limit the disclosed subject matter to those embodiments disclosed.

It will be apparent to those skilled in the art that various modifications and variations can be made in the method and system of the disclosed subject matter t departing from the spirit or scope of the disclosed t matter. Thus, it is ed that the disclosed subject matter include modifications and variations that are within the scope of the appended claims and their equivalents. ~23.

I/WE

Claims (29)

CLAIM :

1. An automatic injection device comprising: a housing having a first end, a second end, and a barrel between the first end and the second end, the barrel sing an elongated window to allow viewing of contents inside the housing; a syringe disposed within the housing and having a first end, a second end, and a reservoir between the first end and the second end; a plunger at least partially disposed within the syringe and comprising a visual indicator on a portion of the plunger; and a syringe carrier disposed within the g and configured to contain the e and displace the syringe within the housing between a first on and a second position, the e carrier being substantially transparent and having at least a first opening configured to align with the window and the oir when the syringe carrier is in the first position.

2. The automatic ion device of claim 1, the housing further comprising a beveled edge surrounding the ted window to receive a shield.

3. The automatic injection device of claim 2, wherein the shield is configured to t UV radiation from entering the housing through the elongated window.

4. The automatic injection device of claim 1, wherein the elongated window has a substantially symmetrical oval shape.

5. The automatic injection device of claim 1, wherein the elongated window has at least one tapered end.

6. The automatic ion device of claim 1, wherein the syringe carrier is configured to allow viewing of substantially all of a liquid therapeutic agent in the reservoir when the syringe carrier is in the first position.

7. The automatic injection device of claim 1, the syringe carrier further comprising a second opening configured to align with the window and the visual indicator when the syringe carrier is in the second position. 11048261_1:hxa

8. The automatic injection device of claim 7, the syringe carrier further comprising a middle portion between the first and second openings, the middle portion sized to resist deformation of the syringe carrier.

9. The automatic injection device of claim 7, wherein the first g is positioned nearer to the first end of the housing than the second opening.

10. The automatic injection device of claim 1, the syringe carrier further sing first and second legs, the first and second legs ng at least a portion of the first opening.

11. The automatic injection device of claim 1, the syringe carrier r comprising first and second pairs of legs, and a second opening, the first opening comprising a front opening portion and a rear opening portion, the first pair of legs defining at least a portion of the front opening n and the second pair of legs defining at least a portion of the rear opening portion.

12. The automatic injection device of claim 1, wherein the first on is a pre-injection position.

13. The tic injection device of claim 1, wherein the second position is a post-injection

14. The automatic injection device of claim 1 further comprising a cap having an outer portion, the first end of the housing configured to receive the outer portion of the cap, the outer portion of the cap comprising a cap notch, a portion of the elongated window being aligned with the cap notch when the cap receives the housing to prevent obstruction of the window.

15. The automatic injection device of claim 1, further comprising a shroud at least partially ed within the housing, a n of the shroud disposed within the housing having a shroud notch, the shroud notch being aligned with at least a portion of the elongated window to prevent obstruction of the window.

16. The automatic injection device of claim 1, further comprising a liquid therapeutic agent in the reservoir, the liquid therapeutic agent having a volume of 0.4 mL. 11048261_1:hxa

17. The automatic injection device of claim 1, r comprising a liquid eutic agent in the oir, the liquid therapeutic agent having a volume of 0.8 mL.

18. The tic injection device of claim 1, further comprising a liquid therapeutic agent in the reservoir, the liquid therapeutic agent comprising a protein.

19. The automatic injection device of claim 1, further comprising a liquid therapeutic agent in the reservoir, the liquid therapeutic agent comprising adalimumab.

20. The automatic injection device of claim 1, further comprising first and second legs and an extension disposed therebetween, at least a portion of the extension configured to align with the window and the reservoir when the syringe carrier is in the first position.

21. The automatic injection device of claim 20, the syringe carrier further comprising a transparent side wall, at least a portion of the transparent side wall being configured to align with the window and the visual indicator when the syringe carrier is in the second position.

22. The automatic ion device of claim 20, wherein the first opening is positioned nearer to the first end of the housing than the second opening.

23. The automatic injection device of claim 20, wherein the first position is a jection position.

24. The automatic injection device of claim 20, n the second position is a postinjection position.

25. The automatic injection device of claim 20, wherein the syringe carrier is configured to allow viewing of substantially all of a liquid therapeutic agent in the reservoir when the syringe carrier is in the first position.

26. The automatic injection device of claim 20, further sing a liquid therapeutic agent in the reservoir, the liquid therapeutic agent having a volume of 0.4 mL.

27. The automatic injection device of claim 20, further sing a liquid therapeutic agent in the reservoir, the liquid therapeutic agent having a volume of 0.8 mL. 11048261_1:hxa

28. The automatic injection device of claim 20, r comprising a liquid therapeutic agent in the reservoir, the liquid eutic agent comprising a protein.

29. The automatic injection device of claim 20, further comprising a liquid therapeutic agent in the reservoir, the liquid therapeutic agent comprising adalimumab. AbbVie, Inc. By the Attorneys for the Applicant SPRUSON & FERGUSON Per: 11048261_1:hxa PCT/U52012/056756 flll'lllllllll.'71)”:'llll villi/l4 m\\\II-fl- ununnluuuiuh- ‘ ""\‘{{'!.‘I{\\\\\\\\\\\“\\\\\\\\\\\\\_\\\\\\x‘xw‘ l.‘,"\~ .._W“Hwy1' .1111. VIIIIII’-' In ..\ f9,4\-.-“-“7/-[If/Illaggj‘ll/I/_l’lltnvl'l _r_l- r vu 3—-,.“..\\\\\\\\\\\\\\\\\\\\\\\\\\\\\‘ . - -_ -_ -_ m. .\k- _- .. --------------:l/l/o//n/aanq' fl\E1/_L\\-u»)!l7—--{m“‘“'I‘:\\\\\\\\\\\\\\\\\\\\\\\ ‘-‘\_““\\\\\\'\'\\\'\‘"\\\\'\\\“\\\\“\.. -- - - -. .. Irm’l/”Ill/1....fil r,u’Iu .IIIIIIIIIIIIIIIII II llll’l’ll’llld\“\‘\§\\\\§\\uva‘1‘--“:UIVIIIIIIIIInuVIAA— /l' 1/ ‘ l‘ IOII| IIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIIII“IIII|““|“' "\‘\‘\ ‘I‘IIIII‘ .II“ “\\\\\\\\\\\\\\m \\\\\\\ .\\\\“‘-I‘.“