NZ500075A - Method for the oral delivery of a protein encapsulated within a hydrogel matrix - Google Patents

Method for the oral delivery of a protein encapsulated within a hydrogel matrix

Info

Publication number
NZ500075A
NZ500075A NZ500075A NZ50007598A NZ500075A NZ 500075 A NZ500075 A NZ 500075A NZ 500075 A NZ500075 A NZ 500075A NZ 50007598 A NZ50007598 A NZ 50007598A NZ 500075 A NZ500075 A NZ 500075A
Authority
NZ
New Zealand
Prior art keywords
hydrogel matrix
oral delivery
protein encapsulated
protein
oral administration
Prior art date
Application number
NZ500075A
Inventor
Nicholas A Peppas
Anthony M Lowman
Tsuneji Nagai
Mariko Morishita
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of NZ500075A publication Critical patent/NZ500075A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A pharmaceutical composition for oral administration which comprises a swellable hydrogel matrix and a labile protein contained therein. The hydrogel matrix comprises a crosslinked co-polymer of methacrylic acid and poly(alkylene glycol) monomethacrylate. Also described is a method of administering a therapeutically effective amount of a protein to a non-human vertebrate which comprises orally administering the abovementioned composition. Further described is the use of the abovementioned composition in the preparation of a pharmaceutical composition formulated for oral administration.
NZ500075A 1997-04-02 1998-04-02 Method for the oral delivery of a protein encapsulated within a hydrogel matrix NZ500075A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4228097P 1997-04-02 1997-04-02
US6136797P 1997-10-08 1997-10-08
PCT/US1998/006563 WO1998043615A1 (en) 1997-04-02 1998-04-02 Method for oral delivery of proteins

Publications (1)

Publication Number Publication Date
NZ500075A true NZ500075A (en) 2001-03-30

Family

ID=26719055

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ500075A NZ500075A (en) 1997-04-02 1998-04-02 Method for the oral delivery of a protein encapsulated within a hydrogel matrix

Country Status (14)

Country Link
EP (1) EP0975328A1 (en)
JP (1) JP2002512607A (en)
KR (1) KR20010005952A (en)
CN (1) CN1259045A (en)
AU (1) AU727053B2 (en)
BR (1) BR9808466A (en)
CA (1) CA2285457A1 (en)
IL (1) IL132176A0 (en)
NO (1) NO994757L (en)
NZ (1) NZ500075A (en)
PL (1) PL335974A1 (en)
TR (1) TR199903240T2 (en)
WO (1) WO1998043615A1 (en)
YU (1) YU49699A (en)

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US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
DE10040592A1 (en) * 2000-08-15 2002-03-07 Aventis Res & Tech Gmbh & Co Composition for oral administration of drugs, e.g. peptidomimetics or sparingly soluble antibiotics, containing hydrogel copolymer of unsaturated acid and polyalkylene glycol ester as resorption improver
US6878384B2 (en) 2001-03-13 2005-04-12 Microvention, Inc. Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use
CA2479751C (en) 2002-03-20 2008-06-03 Trent Poole Inhalation apparatus
BRPI0514263B8 (en) 2004-08-20 2021-05-25 Mannkind Corp method for the synthesis of n-protected bis-3,6-[4-aminobutyl]-2,5-diketopiperazine n-protected
DK2314298T3 (en) 2004-08-23 2015-06-15 Mannkind Corp Microparticles comprising diketopiperazinsalte for drug delivery
US8110212B2 (en) 2005-04-07 2012-02-07 Drexel University Bioactive thermogelling polymer systems and methods of their use
DK1916995T4 (en) 2005-07-29 2022-10-03 Stichting Groningen Centre For Drug Res PH-CONTROLLED, PULSABLE DELIVERY SYSTEM, METHODS OF MANUFACTURE AND USE THEREOF
AU2006275424B2 (en) * 2005-08-01 2013-01-10 Mannkind Corporation Method of preserving the function of insulin-producing cells
US7803404B2 (en) 2005-09-14 2010-09-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
BRPI0707991B8 (en) 2006-02-22 2021-05-25 Mannkind Corp methods of preparing a dry powder medicine with an improved pharmaceutical property, said dry powder and using an effective amount of the dry powder
CN101500623B (en) 2006-06-15 2016-08-24 微温森公司 A kind of embolization device being made up of expandable polymer
WO2009086208A2 (en) 2007-12-21 2009-07-09 Microvention, Inc. Hydrogel filaments for biomedical uses
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
AU2009257311B2 (en) 2008-06-13 2014-12-04 Mannkind Corporation A dry powder inhaler and system for drug delivery
US9358352B2 (en) 2008-06-13 2016-06-07 Mannkind Corporation Dry powder drug delivery system and methods
DK2300083T3 (en) 2008-06-20 2013-07-22 Mannkind Corp INTERACTIVE DEVICE AND PROCEDURE FOR REAL-TIME PROFILING INHALATION TESTS
TWI494123B (en) 2008-08-11 2015-08-01 Mannkind Corp Use of ultrarapid acting insulin
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
US8538707B2 (en) 2009-03-11 2013-09-17 Mannkind Corporation Apparatus, system and method for measuring resistance of an inhaler
KR101875969B1 (en) 2009-06-12 2018-07-06 맨카인드 코포레이션 Diketopiperazine microparticles with defined specific surface areas
HUP0900482A2 (en) 2009-08-03 2011-03-28 Cera Med Kft Pharmaceutical formulation for oral administration
AU2010298026B2 (en) 2009-09-24 2015-11-05 Microvention, Inc. Injectable hydrogel filaments for biomedical uses
JP5722333B2 (en) 2009-10-26 2015-05-20 マイクロベンション インコーポレイテッド Embolization device composed of expandable polymer
WO2011056889A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
ES2625858T3 (en) 2011-04-01 2017-07-20 Mannkind Corporation Blister pack for pharmaceutical cartridges
WO2012145431A2 (en) 2011-04-18 2012-10-26 Microvention, Inc. Embolic devices
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
JP6018640B2 (en) 2011-10-24 2016-11-02 マンカインド コーポレイション Analgesic composition effective for alleviating pain, and dry powder and dry powder drug delivery system comprising the composition
WO2013158781A1 (en) 2012-04-18 2013-10-24 Microvention, Inc. Embolic devices
ES2624294T3 (en) 2012-07-12 2017-07-13 Mannkind Corporation Dry powder drug delivery systems
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
EP2970149B1 (en) 2013-03-15 2019-08-21 MannKind Corporation Microcrystalline diketopiperazine compositions and methods
CN114848614A (en) 2013-07-18 2022-08-05 曼金德公司 Heat stable dry powder pharmaceutical compositions and methods
WO2015021044A1 (en) * 2013-08-05 2015-02-12 University Of Rochester Compositions and methods for stimuli-responsive release of a therapeutic agent
CA2920488C (en) 2013-08-05 2022-04-26 Mannkind Corporation Insufflation apparatus and methods
WO2015148905A1 (en) 2014-03-28 2015-10-01 Mannkind Corporation Use of ultrarapid acting insulin
US10124090B2 (en) 2014-04-03 2018-11-13 Terumo Corporation Embolic devices
US10226533B2 (en) 2014-04-29 2019-03-12 Microvention, Inc. Polymer filaments including pharmaceutical agents and delivering same
WO2015167751A1 (en) 2014-04-29 2015-11-05 Microvention, Inc. Polymers
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
US10265405B2 (en) 2014-11-18 2019-04-23 Board Of Regents, The University Of Texas System Polymers for delivery of factor VIII and/or factor IX
WO2016201250A1 (en) 2015-06-11 2016-12-15 Microvention, Inc. Expansile device for implantation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2976576A (en) * 1956-04-24 1961-03-28 Wichterle Otto Process for producing shaped articles from three-dimensional hydrophilic high polymers
US3220960A (en) * 1960-12-21 1965-11-30 Wichterle Otto Cross-linked hydrophilic polymers and articles made therefrom
ES335314A1 (en) * 1966-01-06 1967-12-01 Ceskoslovenska Akademie Ved Improvements introduced in the preparation of insoluble vehicles of substances at least partially soluble, biologically active. (Machine-translation by Google Translate, not legally binding)
US3607848A (en) * 1967-08-07 1971-09-21 Ceskoslovenska Akademie Ved Method for preparing insoluble,cross-linked organic hydrogels comprising copolymers of glycol monoesters with diesters
US3885078A (en) * 1968-03-06 1975-05-20 Ceskoslovenska Akademie Ved Hydrogel laminates and method of manufacturing thereof
US4071508A (en) * 1975-02-11 1978-01-31 Plastomedical Sciences, Inc. Anionic hydrogels based on hydroxyalkyl acrylates and methacrylates
FR2601026B1 (en) * 1986-04-15 1988-09-16 Rhone Poulenc Chimie DRY MATERIAL MOISTURIZABLE IN AN AQUEOUS GEL CONTAINING PARTICLES OF DISPERSE POLYMERS, METHOD FOR ITS PREPARATION AND ITS APPLICATION IN BIOLOGY

Also Published As

Publication number Publication date
YU49699A (en) 2002-12-10
CN1259045A (en) 2000-07-05
AU6880998A (en) 1998-10-22
NO994757L (en) 1999-11-29
AU727053B2 (en) 2000-11-30
CA2285457A1 (en) 1998-10-08
NO994757D0 (en) 1999-09-30
WO1998043615A1 (en) 1998-10-08
IL132176A0 (en) 2001-03-19
KR20010005952A (en) 2001-01-15
TR199903240T2 (en) 2000-05-22
BR9808466A (en) 2001-08-07
EP0975328A1 (en) 2000-02-02
JP2002512607A (en) 2002-04-23
PL335974A1 (en) 2000-06-05

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