NO305555B1 - Kondenserte indan-derivater og farmas°ytisk akseptable salter derav, preparat og anti-tumormiddel - Google Patents
Kondenserte indan-derivater og farmas°ytisk akseptable salter derav, preparat og anti-tumormiddelInfo
- Publication number
- NO305555B1 NO305555B1 NO960239A NO960239A NO305555B1 NO 305555 B1 NO305555 B1 NO 305555B1 NO 960239 A NO960239 A NO 960239A NO 960239 A NO960239 A NO 960239A NO 305555 B1 NO305555 B1 NO 305555B1
- Authority
- NO
- Norway
- Prior art keywords
- group
- substituted
- optionally substituted
- ring
- pharmaceutically acceptable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10719094 | 1994-05-20 | ||
| PCT/JP1995/000944 WO1995032187A1 (fr) | 1994-05-20 | 1995-05-18 | Nouveau derive d'indane fusionne et sel dudit derive acceptable pharmaceutiquement |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO960239D0 NO960239D0 (no) | 1996-01-19 |
| NO960239L NO960239L (no) | 1996-03-18 |
| NO305555B1 true NO305555B1 (no) | 1999-06-21 |
Family
ID=14452758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO960239A NO305555B1 (no) | 1994-05-20 | 1996-01-19 | Kondenserte indan-derivater og farmas°ytisk akseptable salter derav, preparat og anti-tumormiddel |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US5733918A (no) |
| EP (1) | EP0713870B1 (no) |
| KR (1) | KR100190732B1 (no) |
| CN (1) | CN1131216C (no) |
| AT (1) | ATE203236T1 (no) |
| AU (1) | AU685631B2 (no) |
| CA (1) | CA2167382C (no) |
| DE (1) | DE69521770T2 (no) |
| DK (1) | DK0713870T3 (no) |
| ES (1) | ES2158109T3 (no) |
| FI (1) | FI111721B (no) |
| GR (1) | GR3036795T3 (no) |
| HU (1) | HU218308B (no) |
| IL (1) | IL113778A (no) |
| NO (1) | NO305555B1 (no) |
| NZ (1) | NZ285448A (no) |
| PT (1) | PT713870E (no) |
| RU (1) | RU2124017C1 (no) |
| TW (1) | TW440562B (no) |
| WO (1) | WO1995032187A1 (no) |
| ZA (1) | ZA954077B (no) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3141148B2 (ja) * | 1995-08-08 | 2001-03-05 | 大鵬薬品工業株式会社 | 縮合インダン誘導体及びその塩 |
| US6956035B2 (en) * | 2001-08-31 | 2005-10-18 | Inotek Pharmaceuticals Corporation | Isoquinoline derivatives and methods of use thereof |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
| ATE316971T1 (de) * | 2001-10-05 | 2006-02-15 | Hoffmann La Roche | Polycyclische verbindungen mit antitumor-wirkung |
| US6946472B2 (en) | 2002-04-30 | 2005-09-20 | Hoffman-La Roche Inc. | Polycyclic compounds exhibiting anti-tumor activities |
| CL2004000366A1 (es) * | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
| BRPI0407757A (pt) * | 2003-02-28 | 2006-02-14 | Inotek Pharmaceuticals Corp | derivados de benzamida tetracìclica e métodos de uso dos mesmos |
| EP1722797A4 (en) * | 2004-02-26 | 2008-03-19 | Inotek Pharmaceuticals Corp | ISOCHINOLINE DERIVATIVES AND METHOD FOR THE APPLICATION THEREOF |
| JP2007525526A (ja) * | 2004-02-26 | 2007-09-06 | イノテック ファーマシューティカルズ コーポレイション | 四環系ラクタム誘導体およびその使用 |
| US20060019980A1 (en) * | 2004-06-16 | 2006-01-26 | Inotek Pharmaceutical, Corp. | Methods for treating or preventing erectile dysfunction or urinary incontinence |
| CN101128431B (zh) * | 2005-02-24 | 2011-05-25 | 詹森药业有限公司 | 作为钾离子通道打开剂的喹啉衍生物 |
| JP2008531563A (ja) * | 2005-02-25 | 2008-08-14 | イノテック ファーマシューティカルズ コーポレイション | 四環スルホンアミド化合物およびこれらの使用法 |
| US7381722B2 (en) * | 2005-02-25 | 2008-06-03 | Inotek Pharmaceuticals Corporation | Tetracyclic amino and carboxamido compounds and methods of use thereof |
| AU2006219022A1 (en) * | 2005-02-25 | 2006-09-08 | Inotek Pharmaceuticals Corporation | Isoqunoline Compounds and methods of use thereof |
| KR20080039508A (ko) * | 2005-08-24 | 2008-05-07 | 이노텍 파마슈티컬스 코포레이션 | 인데노이소퀴놀리논 유사체 및 이의 사용 방법 |
| CA2677046A1 (en) * | 2007-02-28 | 2008-09-04 | Inotek Pharmaceuticals Corporation | Indenoisoquinolinone analogs and methods of use thereof |
| CN103102304B (zh) * | 2013-01-19 | 2015-03-11 | 安徽师范大学 | N-磺酰基取代四氢异喹啉衍生物的制备方法 |
| HUE034807T2 (en) | 2013-08-22 | 2018-02-28 | Taiho Pharmaceutical Co Ltd | New quinoline-substituted compound |
| JOP20190073A1 (ar) | 2016-10-31 | 2019-04-07 | Taiho Pharmaceutical Co Ltd | مثبط انتقائي لمستقبل عامل نمو بشروي (egfr) لطافر إدخال exon 20 |
| JOP20200044A1 (ar) | 2017-09-01 | 2020-02-26 | Taiho Pharmaceutical Co Ltd | مثبط انتقائي egfr طافر exon 18 و/أو exon 21 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223506A (en) * | 1991-06-04 | 1993-06-29 | Glaxo Inc. | Cyclic antitumor compounds |
-
1995
- 1995-05-17 TW TW084104882A patent/TW440562B/zh not_active IP Right Cessation
- 1995-05-18 CA CA002167382A patent/CA2167382C/en not_active Expired - Fee Related
- 1995-05-18 ES ES95918733T patent/ES2158109T3/es not_active Expired - Lifetime
- 1995-05-18 WO PCT/JP1995/000944 patent/WO1995032187A1/ja active IP Right Grant
- 1995-05-18 IL IL11377895A patent/IL113778A/xx not_active IP Right Cessation
- 1995-05-18 AT AT95918733T patent/ATE203236T1/de not_active IP Right Cessation
- 1995-05-18 PT PT95918733T patent/PT713870E/pt unknown
- 1995-05-18 EP EP95918733A patent/EP0713870B1/en not_active Expired - Lifetime
- 1995-05-18 CN CN95190639A patent/CN1131216C/zh not_active Expired - Fee Related
- 1995-05-18 KR KR1019960700277A patent/KR100190732B1/ko not_active IP Right Cessation
- 1995-05-18 DK DK95918733T patent/DK0713870T3/da active
- 1995-05-18 NZ NZ285448A patent/NZ285448A/en unknown
- 1995-05-18 DE DE69521770T patent/DE69521770T2/de not_active Expired - Fee Related
- 1995-05-18 US US08/578,542 patent/US5733918A/en not_active Expired - Fee Related
- 1995-05-18 RU RU96105034A patent/RU2124017C1/ru not_active IP Right Cessation
- 1995-05-18 HU HU9600130A patent/HU218308B/hu not_active IP Right Cessation
- 1995-05-18 AU AU24542/95A patent/AU685631B2/en not_active Ceased
- 1995-05-18 ZA ZA954077A patent/ZA954077B/xx unknown
-
1996
- 1996-01-19 NO NO960239A patent/NO305555B1/no unknown
- 1996-01-19 FI FI960280A patent/FI111721B/fi active
- 1996-09-12 US US08/713,224 patent/US5710162A/en not_active Expired - Fee Related
-
1997
- 1997-08-12 US US08/909,934 patent/US6028079A/en not_active Expired - Fee Related
-
2001
- 2001-10-04 GR GR20010401657T patent/GR3036795T3/el not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0713870B1 (en) | 2001-07-18 |
| FI960280A (fi) | 1996-03-18 |
| ZA954077B (en) | 1996-01-19 |
| CN1131216C (zh) | 2003-12-17 |
| CA2167382A1 (en) | 1995-11-30 |
| ES2158109T3 (es) | 2001-09-01 |
| DE69521770T2 (de) | 2002-05-23 |
| NO960239L (no) | 1996-03-18 |
| WO1995032187A1 (fr) | 1995-11-30 |
| FI111721B (fi) | 2003-09-15 |
| FI960280A0 (fi) | 1996-01-19 |
| CA2167382C (en) | 1999-08-31 |
| IL113778A0 (en) | 1995-08-31 |
| HUT75651A (en) | 1997-05-28 |
| US5733918A (en) | 1998-03-31 |
| GR3036795T3 (en) | 2002-01-31 |
| PT713870E (pt) | 2001-11-30 |
| DE69521770D1 (de) | 2001-08-23 |
| RU2124017C1 (ru) | 1998-12-27 |
| ATE203236T1 (de) | 2001-08-15 |
| KR960703864A (ko) | 1996-08-31 |
| US5710162A (en) | 1998-01-20 |
| TW440562B (en) | 2001-06-16 |
| DK0713870T3 (da) | 2001-09-24 |
| AU2454295A (en) | 1995-12-18 |
| US6028079A (en) | 2000-02-22 |
| AU685631B2 (en) | 1998-01-22 |
| HU218308B (en) | 2000-07-28 |
| CN1130903A (zh) | 1996-09-11 |
| NO960239D0 (no) | 1996-01-19 |
| EP0713870A1 (en) | 1996-05-29 |
| EP0713870A4 (en) | 1996-12-18 |
| NZ285448A (en) | 1997-11-24 |
| KR100190732B1 (ko) | 1999-06-01 |
| IL113778A (en) | 1999-09-22 |
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