NO20064351L - Caspaseinhibitorer og anvendelser derav - Google Patents
Caspaseinhibitorer og anvendelser deravInfo
- Publication number
- NO20064351L NO20064351L NO20064351A NO20064351A NO20064351L NO 20064351 L NO20064351 L NO 20064351L NO 20064351 A NO20064351 A NO 20064351A NO 20064351 A NO20064351 A NO 20064351A NO 20064351 L NO20064351 L NO 20064351L
- Authority
- NO
- Norway
- Prior art keywords
- caspase inhibitors
- compounds
- formula
- present
- provides
- Prior art date
Links
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- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
Foreliggende oppfinnelse tilveiebringer en forbindelse med formel I: hvori variablene er som definert i beskrivelsen. Foreliggende oppfinnelse tilveiebringer også fremgangsmåter for å fremstille forbindelsene med formel I og mellomprodukter derav, farmasøytiske sammensetninger omfattende disse forbindelser og metoder for anvendelse av forbindelsene og sammensetninger.
Applications Claiming Priority (4)
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US54861004P | 2004-02-27 | 2004-02-27 | |
US62966104P | 2004-11-19 | 2004-11-19 | |
US62974304P | 2004-11-19 | 2004-11-19 | |
PCT/US2005/006540 WO2005085236A2 (en) | 2004-02-27 | 2005-02-28 | Caspase inhibitors and uses thereof |
Publications (1)
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NO20064351L true NO20064351L (no) | 2006-11-20 |
Family
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NO20064351A NO20064351L (no) | 2004-02-27 | 2006-09-26 | Caspaseinhibitorer og anvendelser derav |
NO20064344A NO20064344L (no) | 2004-02-27 | 2006-09-26 | Caspaseinhibitorer og anvendelser derav |
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NO20064344A NO20064344L (no) | 2004-02-27 | 2006-09-26 | Caspaseinhibitorer og anvendelser derav |
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US (2) | US7652153B2 (no) |
EP (2) | EP2270004A1 (no) |
JP (3) | JP2007525503A (no) |
KR (1) | KR20060129069A (no) |
CN (1) | CN102161656B (no) |
AR (1) | AR047981A1 (no) |
AU (1) | AU2005219861B2 (no) |
BR (1) | BRPI0508102A (no) |
CA (1) | CA2557645C (no) |
HK (2) | HK1099757A1 (no) |
IL (1) | IL177709A0 (no) |
NO (2) | NO20064351L (no) |
NZ (1) | NZ549665A (no) |
RU (1) | RU2382780C2 (no) |
TW (2) | TWI362381B (no) |
WO (1) | WO2005085236A2 (no) |
ZA (1) | ZA200607634B (no) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
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DE69939689D1 (de) * | 1998-03-19 | 2008-11-20 | Vertex Pharma | Caspase inhibitoren |
PE20011350A1 (es) | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
KR101135765B1 (ko) * | 2004-03-12 | 2012-04-23 | 버텍스 파마슈티칼스 인코포레이티드 | 아스파르트산 아세탈 카스파아제 억제제의 제조를 위한방법 및 중간체 |
JP4848367B2 (ja) * | 2004-05-15 | 2011-12-28 | バーテックス ファーマシューティカルズ インコーポレイテッド | Iceインヒビターを使用した発作の処置 |
EP2295054A1 (en) * | 2004-05-27 | 2011-03-16 | Vertex Pharmaceuticals Incorporated | Ice inhibitors for the treatment of autoinflammatory diseases |
US9365612B2 (en) | 2010-01-29 | 2016-06-14 | United States Of America As Represented By The Secretary, Department Of Health And Human Services | Caspase inhibitors |
US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
WO2015175381A1 (en) | 2014-05-12 | 2015-11-19 | Conatus Pharmaceuticals, Inc. | Treatment of the complications of chronic liver disease with caspase inhibitors |
WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
KR20180101418A (ko) | 2015-12-31 | 2018-09-12 | 코나터스 파마슈티칼스, 인크. | 간 질환의 치료에서의 카스파제 억제제의 사용 방법 |
CN105853408B (zh) * | 2016-04-15 | 2018-12-04 | 浙江大学 | 苯酰胺衍生物在制备Caspase-1抑制剂中的应用 |
CA3039283A1 (en) | 2016-10-05 | 2018-04-12 | Novartis Ag | Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder |
WO2022123062A1 (en) | 2020-12-11 | 2022-06-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6204261B1 (en) * | 1995-12-20 | 2001-03-20 | Vertex Pharmaceuticals Incorporated | Inhibitors of interleukin-1β Converting enzyme inhibitors |
US5716929A (en) * | 1994-06-17 | 1998-02-10 | Vertex Pharmaceuticals, Inc. | Inhibitors of interleukin-1β converting enzyme |
JP3492703B2 (ja) * | 1996-09-12 | 2004-02-03 | アイドゥン ファーマシューティカルズ,インコーポレイテッド | システインプロテアーゼのICE/ced―3ファミリーの阻害剤としてのC―末端変性(N―置換)―2―インドリルジペプチド |
DE69734718T2 (de) * | 1996-09-12 | 2006-08-24 | Idun Pharmaceuticals, Inc., San Diego | Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie |
FR2766188B1 (fr) | 1997-07-15 | 2000-02-11 | Hoechst Marion Roussel Inc | Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes |
DE69939689D1 (de) * | 1998-03-19 | 2008-11-20 | Vertex Pharma | Caspase inhibitoren |
US7053056B2 (en) | 1998-07-02 | 2006-05-30 | Idun Pharmaceuticals, Inc. | C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases |
EP1179345B1 (en) | 1999-01-29 | 2009-04-08 | Senju Pharmaceutical Co., Ltd. | Inhibitors against increase in ocular tension caused by irradiation with lasers, containing 1,4-dihydropyridine derivatives |
SK15592002A3 (sk) | 2000-04-24 | 2003-04-01 | Vertex Pharmaceuticals Incorporated | Spôsob a medziprodukty na prípravu substituovaných acetálov kyseliny aspartovej |
PE20011350A1 (es) * | 2000-05-19 | 2002-01-15 | Vertex Pharma | PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE) |
WO2001090070A2 (en) | 2000-05-23 | 2001-11-29 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
IL152845A0 (en) | 2000-06-07 | 2003-06-24 | Vertex Pharma | Fused heterocyclic compounds and pharmaceutical compositions containing the same |
PE20020500A1 (es) | 2000-09-13 | 2002-06-25 | Vertex Pharma | Derivados de piperidina, tetrahidroquinolina, tetrahidroisoquinolina como inhibidores de caspasas |
EP1381602A1 (en) | 2001-04-19 | 2004-01-21 | Vertex Pharmaceuticals Incorporated | Heterocyclyldicarbamides as caspase inhibitors |
US6645994B1 (en) | 2001-06-01 | 2003-11-11 | Alcon, Inc. | Method of treating dry eye disorders |
EP1485107A1 (en) | 2002-02-11 | 2004-12-15 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
KR101135765B1 (ko) * | 2004-03-12 | 2012-04-23 | 버텍스 파마슈티칼스 인코포레이티드 | 아스파르트산 아세탈 카스파아제 억제제의 제조를 위한방법 및 중간체 |
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2005
- 2005-02-28 AR ARP050100737A patent/AR047981A1/es unknown
- 2005-02-28 BR BRPI0508102-5A patent/BRPI0508102A/pt not_active IP Right Cessation
- 2005-02-28 EP EP10013186A patent/EP2270004A1/en not_active Withdrawn
- 2005-02-28 KR KR1020067019903A patent/KR20060129069A/ko not_active Application Discontinuation
- 2005-02-28 CN CN2010106215884A patent/CN102161656B/zh not_active Expired - Fee Related
- 2005-02-28 NZ NZ549665A patent/NZ549665A/en not_active IP Right Cessation
- 2005-02-28 EP EP05724143A patent/EP1718639A2/en not_active Withdrawn
- 2005-02-28 US US11/069,895 patent/US7652153B2/en not_active Expired - Fee Related
- 2005-02-28 JP JP2007500824A patent/JP2007525503A/ja active Pending
- 2005-02-28 AU AU2005219861A patent/AU2005219861B2/en not_active Ceased
- 2005-02-28 RU RU2006134258/04A patent/RU2382780C2/ru not_active IP Right Cessation
- 2005-02-28 CA CA2557645A patent/CA2557645C/en not_active Expired - Fee Related
- 2005-02-28 WO PCT/US2005/006540 patent/WO2005085236A2/en active Application Filing
- 2005-03-01 TW TW094106099A patent/TWI362381B/zh not_active IP Right Cessation
- 2005-03-01 TW TW101100244A patent/TW201217332A/zh unknown
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2006
- 2006-08-27 IL IL177709A patent/IL177709A0/en not_active IP Right Cessation
- 2006-09-12 ZA ZA2006/07634A patent/ZA200607634B/en unknown
- 2006-09-26 NO NO20064351A patent/NO20064351L/no not_active Application Discontinuation
- 2006-09-26 NO NO20064344A patent/NO20064344L/no unknown
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2007
- 2007-07-03 HK HK07107033.7A patent/HK1099757A1/xx not_active IP Right Cessation
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2009
- 2009-12-03 US US12/630,350 patent/US20100105914A1/en not_active Abandoned
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2011
- 2011-04-21 JP JP2011095553A patent/JP2011144203A/ja not_active Withdrawn
- 2011-12-29 HK HK11114041.7A patent/HK1159614A1/xx not_active IP Right Cessation
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2014
- 2014-05-09 JP JP2014097786A patent/JP2014140385A/ja active Pending
Also Published As
Publication number | Publication date |
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WO2005085236A2 (en) | 2005-09-15 |
NO20064344L (no) | 2006-10-19 |
RU2006134258A (ru) | 2008-04-10 |
AU2005219861B2 (en) | 2011-08-11 |
EP2270004A1 (en) | 2011-01-05 |
JP2011144203A (ja) | 2011-07-28 |
US20100105914A1 (en) | 2010-04-29 |
CN102161656B (zh) | 2013-02-20 |
ZA200607634B (en) | 2008-01-08 |
AU2005219861A1 (en) | 2005-09-15 |
RU2382780C2 (ru) | 2010-02-27 |
NZ549665A (en) | 2010-09-30 |
BRPI0508102A (pt) | 2007-07-17 |
US20050233979A1 (en) | 2005-10-20 |
TWI362381B (en) | 2012-04-21 |
TW201217332A (en) | 2012-05-01 |
KR20060129069A (ko) | 2006-12-14 |
JP2007525503A (ja) | 2007-09-06 |
AR047981A1 (es) | 2006-03-15 |
US7652153B2 (en) | 2010-01-26 |
CN102161656A (zh) | 2011-08-24 |
JP2014140385A (ja) | 2014-08-07 |
HK1099757A1 (en) | 2007-08-24 |
HK1159614A1 (en) | 2012-08-03 |
EP1718639A2 (en) | 2006-11-08 |
TW200540152A (en) | 2005-12-16 |
CA2557645A1 (en) | 2005-09-15 |
WO2005085236A3 (en) | 2005-10-20 |
IL177709A0 (en) | 2006-12-31 |
CA2557645C (en) | 2013-09-24 |
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