NO20041272L - Tetracycline derivatives and methods of use thereof - Google Patents

Tetracycline derivatives and methods of use thereof

Info

Publication number
NO20041272L
NO20041272L NO20041272A NO20041272A NO20041272L NO 20041272 L NO20041272 L NO 20041272L NO 20041272 A NO20041272 A NO 20041272A NO 20041272 A NO20041272 A NO 20041272A NO 20041272 L NO20041272 L NO 20041272L
Authority
NO
Norway
Prior art keywords
methods
tetracycline derivatives
tetracycline
derivatives
Prior art date
Application number
NO20041272A
Other languages
English (en)
Inventor
Joseph John Hlavka
Richard D Ablin
Original Assignee
Tetragenex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tetragenex Pharmaceuticals Inc filed Critical Tetragenex Pharmaceuticals Inc
Publication of NO20041272L publication Critical patent/NO20041272L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
NO20041272A 2001-10-05 2004-03-26 Tetracycline derivatives and methods of use thereof NO20041272L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32750201P 2001-10-05 2001-10-05
PCT/US2002/031730 WO2003030819A2 (en) 2001-10-05 2002-10-04 Tetracycline derivatives and methods of use thereof

Publications (1)

Publication Number Publication Date
NO20041272L true NO20041272L (no) 2004-07-02

Family

ID=23276795

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20041272A NO20041272L (no) 2001-10-05 2004-03-26 Tetracycline derivatives and methods of use thereof

Country Status (10)

Country Link
US (4) US7214669B2 (no)
EP (1) EP1439843A4 (no)
JP (1) JP2005505588A (no)
CN (2) CN1564690A (no)
AU (1) AU2002341970B2 (no)
CA (1) CA2462572C (no)
MY (1) MY133403A (no)
NO (1) NO20041272L (no)
RU (1) RU2300380C2 (no)
WO (1) WO2003030819A2 (no)

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WO2002072506A2 (en) * 2001-03-13 2002-09-19 Paratek Pharmaceuticals, Inc. 7-pyrollyl tetracycline compounds and methods of use thereof
JP2005506291A (ja) * 2001-03-13 2005-03-03 パラテック ファーマシューティカルズ， インク． ７，９−置換テトラサイクリン化合物
MY133403A (en) * 2001-10-05 2007-11-30 Tetragenex Pharmaceuticals Inc Tetracycline derivatives and methods of use thereof
US20050026833A1 (en) * 2001-11-08 2005-02-03 Rabbani Shafaat Ahmed PSP-94: use for treatment of hypercalcemia and bone metastasis
EP2311799A1 (en) * 2002-01-08 2011-04-20 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
JP4686189B2 (ja) * 2002-10-24 2011-05-18 パラテック ファーマシューティカルズ インコーポレイテッド Ｒｎａを調節するための置換テトラサイクリン化合物の使用方法
AU2004259659B2 (en) 2003-07-09 2011-11-03 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
US8012950B2 (en) * 2003-08-29 2011-09-06 Wisconsin Alumni Research Foundation Method to diagnose and treat degenerative joint disease
EP2332904A3 (en) * 2004-01-15 2012-04-11 Paratek Pharmaceuticals, Inc. Derivatives of tetracycline compounds
KR101171408B1 (ko) 2004-05-21 2012-08-08 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 테트라사이클린 및 이의 유사체의 합성
EP2301916A3 (en) 2004-10-25 2011-09-28 Paratek Pharmaceuticals, Inc. 4-aminotetracyclines and methods of use thereof
AU2006210406C1 (en) 2005-02-04 2013-03-07 Paratek Pharmaceuticals, Inc. 11a, 12-derivatives of tetracycline compounds
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
US8486921B2 (en) * 2006-04-07 2013-07-16 President And Fellows Of Harvard College Synthesis of tetracyclines and analogues thereof
EP2537934A3 (en) * 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
EP2479169B1 (en) 2006-10-11 2014-12-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
US8440646B1 (en) 2006-10-11 2013-05-14 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds for treatment of Bacillus anthracis infections
US9073829B2 (en) 2009-04-30 2015-07-07 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
PL2327676T3 (pl) * 2009-11-26 2014-08-29 Sandoz Ag Reakcja związków organicznych z małymi ilościami wodoru
WO2011109899A1 (en) * 2010-03-10 2011-09-15 University Health Network Use of tigecycline for treatment of cancer
CN102631356B (zh) * 2012-04-11 2014-03-12 广州市东来生物科技有限公司 4-去二甲氨基四环素衍生物在抗幽门螺旋杆菌方面的用途
CN104394856A (zh) * 2012-05-21 2015-03-04 Dcb美国公司 以斑马鱼模型进行药物筛选的方法及筛选所得药物
MA40836A (fr) * 2014-10-23 2017-08-29 Tetraphase Pharmaceuticals Inc Procédures de semi-synthèse
EP3612540A1 (en) 2017-04-20 2020-02-26 Rising Tide Foundation Triphenylphosphonium-tethered tetracycyclines for use in treating cancer
CN110156624B (zh) * 2019-05-29 2022-03-08 河北冀衡药业股份有限公司 一种米诺环素及其衍生物的合成方法
AR127596A1 (es) 2021-02-03 2024-02-14 Consejo Nacional De Investigaciones Cientificas Y Tecn Conicet Transportador acoplado químicamente para drogas bioactivas de baja hidrofobicidad en el sistema nervioso central

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Also Published As

Publication number Publication date
EP1439843A2 (en) 2004-07-28
US7214669B2 (en) 2007-05-08
US20050245491A9 (en) 2005-11-03
US20070142338A1 (en) 2007-06-21
RU2004109986A (ru) 2005-02-20
CN1961885A (zh) 2007-05-16
CN1564690A (zh) 2005-01-12
US20070149488A1 (en) 2007-06-28
MY133403A (en) 2007-11-30
US20050267079A1 (en) 2005-12-01
JP2005505588A (ja) 2005-02-24
CA2462572A1 (en) 2003-04-17
WO2003030819A3 (en) 2004-01-08
US20040067912A1 (en) 2004-04-08
RU2300380C2 (ru) 2007-06-10
EP1439843A4 (en) 2007-01-03
WO2003030819A2 (en) 2003-04-17
AU2002341970B2 (en) 2008-02-14
CA2462572C (en) 2008-11-18

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FC2A Withdrawal, rejection or dismissal of laid open patent application