NO20040511L - Aminoisoxazolderivater som kinaseinhibitorer - Google Patents
Aminoisoxazolderivater som kinaseinhibitorerInfo
- Publication number
- NO20040511L NO20040511L NO20040511A NO20040511A NO20040511L NO 20040511 L NO20040511 L NO 20040511L NO 20040511 A NO20040511 A NO 20040511A NO 20040511 A NO20040511 A NO 20040511A NO 20040511 L NO20040511 L NO 20040511L
- Authority
- NO
- Norway
- Prior art keywords
- compounds
- kinase inhibitors
- aminoisoxazole derivatives
- aminoisoxazole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Det beskrives forbindelser med formel (I) som er aminoisoksazolderivater, eller farmasøytisk akseptable salter derav, sammen med farmasøytiske preparater omfattende forbindelsene.Forbindelsene eller preparatene har anvendelse ved terapi av sykdommer forårsaket av og/eller forbundet med en endret proteinkinase-aktivitet som cancer, celleproliferative lidelser, Alzheimers sykdom, virale infeksjoner, autoimmune sykdommer og neuro-degenerative lidelser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92175101A | 2001-08-06 | 2001-08-06 | |
PCT/EP2002/008634 WO2003013517A1 (en) | 2001-08-06 | 2002-07-29 | Aminoisoxazole derivatives active as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20040511L true NO20040511L (no) | 2004-03-23 |
Family
ID=25445927
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20040511A NO20040511L (no) | 2001-08-06 | 2004-02-03 | Aminoisoxazolderivater som kinaseinhibitorer |
Country Status (18)
Country | Link |
---|---|
US (1) | US20050059657A1 (no) |
EP (1) | EP1435948A1 (no) |
JP (1) | JP2005501073A (no) |
KR (1) | KR20040030941A (no) |
CN (1) | CN1549714A (no) |
AU (1) | AU2002342607B2 (no) |
BR (1) | BR0211742A (no) |
CA (1) | CA2455631A1 (no) |
CO (1) | CO5640104A2 (no) |
CZ (1) | CZ2004168A3 (no) |
EA (1) | EA006769B1 (no) |
IL (1) | IL159926A0 (no) |
MX (1) | MXPA04000920A (no) |
NO (1) | NO20040511L (no) |
NZ (1) | NZ530782A (no) |
PL (1) | PL368403A1 (no) |
WO (1) | WO2003013517A1 (no) |
ZA (1) | ZA200400347B (no) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005514330A (ja) * | 2001-09-24 | 2005-05-19 | イーラン ファーマスーティカルズ、インコーポレイテッド | アルツハイマー病治療のための置換アミン |
CA2900181C (en) | 2003-08-06 | 2019-01-29 | Catherine Tachdjian | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
JP2007512255A (ja) | 2003-11-13 | 2007-05-17 | アンビット バイオサイエンシス コーポレーション | キナーゼ調節因子としての尿素誘導体 |
WO2005061519A1 (en) * | 2003-12-19 | 2005-07-07 | Takeda San Diego, Inc. | Kinase inhibitors |
JP2007533753A (ja) * | 2004-04-23 | 2007-11-22 | タケダ サン ディエゴ インコーポレイテッド | インドール誘導体及びキナーゼ阻害剤としてのその使用 |
AU2005245389A1 (en) * | 2004-05-12 | 2005-12-01 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
US7550499B2 (en) | 2004-05-12 | 2009-06-23 | Bristol-Myers Squibb Company | Urea antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
EP1778669A2 (en) * | 2004-08-18 | 2007-05-02 | Takeda San Diego, Inc. | Kinase inhibitors |
DE602005023333D1 (de) | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
EP1954696B1 (en) | 2005-01-19 | 2011-02-23 | Bristol-Myers Squibb Company | 2-phenoxy-n-(1,3,4-thiadizol-2-yl)pyridin-3-amine derivatives and related compounds as p2y1 receptor inhibitors for the treatment of thromboembolic disorders |
TWI375521B (en) | 2005-02-04 | 2012-11-01 | Senomyx Inc | Compounds comprising linked heteroaryl moieties and their use as novel umami flavor modifiers, tastants and taste enhancers for comestible compositions |
JP5147109B2 (ja) | 2005-06-07 | 2013-02-20 | 塩野義製薬株式会社 | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 |
AR055329A1 (es) | 2005-06-15 | 2007-08-15 | Senomyx Inc | Amidas bis-aromaticas y sus usos como modificadores de sabor dulce, saborizantes, y realzadores de sabor |
EP1896466B1 (en) | 2005-06-27 | 2011-04-13 | Bristol-Myers Squibb Company | N-linked heterocyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
US7714002B2 (en) | 2005-06-27 | 2010-05-11 | Bristol-Myers Squibb Company | Carbocycle and heterocycle antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
WO2007002584A1 (en) | 2005-06-27 | 2007-01-04 | Bristol-Myers Squibb Company | Linear urea mimics antagonists of p2y1 receptor useful in the treatment of thrombotic conditions |
ES2352796T3 (es) | 2005-06-27 | 2011-02-23 | Bristol-Myers Squibb Company | Antagonistas cíclicos unidos a c del receptor p2y1 útiles en el tratamiento de afecciones trombóticas. |
EP1772449A1 (en) * | 2005-10-05 | 2007-04-11 | Bayer CropScience S.A. | New N-alkyl-heterocyclyl carboxamide derivatives |
US8119655B2 (en) * | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
CN101277952B (zh) * | 2005-10-11 | 2011-09-28 | 弗·哈夫曼-拉罗切有限公司 | 异*唑衍生物 |
ES2341131T3 (es) * | 2005-11-09 | 2010-06-15 | F.Hoffmann-La Roche Ag | Derivados de 3-aril-isoxazol-4-carbonil-benzofurano. |
KR101394245B1 (ko) | 2005-12-30 | 2014-05-14 | 에스케이바이오팜 주식회사 | 아이속사졸 유도체 및 이의 용도 |
US8017638B2 (en) | 2006-03-30 | 2011-09-13 | Shionogi & Co., Ltd. | Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 |
TWI674069B (zh) | 2006-04-21 | 2019-10-11 | 美商賽諾米克斯公司 | 包含高度鮮味風味劑之可食用組合物及其製造方法 |
DK2076502T3 (da) * | 2006-06-08 | 2011-07-25 | Lilly Co Eli | Substituerede carboxamider som antagonister af gruppe-1 metabotrope receptorer |
US20100120717A1 (en) | 2006-10-09 | 2010-05-13 | Brown Jason W | Kinase inhibitors |
EP2223925A1 (en) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
US8193225B2 (en) | 2006-10-13 | 2012-06-05 | The Board Of Regents Of The University Of Texas System | Isoxazole amides, derivatives and methods of chemical induction of neurogenesis |
WO2008046072A2 (en) * | 2006-10-13 | 2008-04-17 | The Board Of Regents Of The University Of Texas System | Chemical inducers of neurogenesis |
US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
ES2379746T3 (es) * | 2007-06-29 | 2012-05-03 | Sk Biopharmaceuticals Co., Ltd. | Composición farmacéutica para la prevención y el tratamiento de la restenosis que comprende los derivados del isoxazol |
KR101257550B1 (ko) | 2007-09-10 | 2013-04-24 | 칼시메디카, 인크 | 세포내 칼슘을 조절하는 화합물 |
WO2009076454A2 (en) * | 2007-12-12 | 2009-06-18 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
KR101724161B1 (ko) * | 2008-08-27 | 2017-04-06 | 칼시메디카, 인크 | 세포내 칼슘을 조절하는 화합물 |
US8524763B2 (en) | 2008-09-22 | 2013-09-03 | Calcimedica, Inc. | Inhibitors of store operated calcium release |
WO2011034962A2 (en) | 2009-09-16 | 2011-03-24 | Calcimedica Inc. | Compounds that modulate intracellular calcium |
CN103242256A (zh) * | 2013-05-21 | 2013-08-14 | 苏州科捷生物医药有限公司 | 一种3-胺甲基-异噁唑盐酸盐的合成方法 |
KR101646180B1 (ko) | 2014-09-22 | 2016-08-05 | 한양대학교 에리카산학협력단 | N-(5-아릴아미도-2-메틸페닐)-5-메틸이소옥사졸-4-카복스아미드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 fms 키나아제 저해제 |
CN113069451B (zh) * | 2021-04-02 | 2022-08-09 | 苏州大学 | 一种吡咯-2-磺酰胺化合物的制备方法及其在制备抗肿瘤药物中的应用 |
CN116283946B (zh) * | 2023-03-27 | 2024-05-07 | 武汉工程大学 | 5-(n-取代吲哚-5-基)异噁唑-3-甲酸衍生物及其合成方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1108397A (en) * | 1965-08-18 | 1968-04-03 | Geigy Ag J R | 5-nitro-2-furyl-isoxazoles |
GB1162257A (en) * | 1965-09-22 | 1969-08-20 | Danippon Pharmaceutical Co Ltd | 3-(5-Nitro-2-Furyl) Isoxazole Derivatives and methods of preparation thereof |
US3631169A (en) * | 1966-09-22 | 1971-12-28 | Dainippon Pharmaceutical Co | 3-(5-nitro-2-furyl)isoxazoline derivatives |
US3522252A (en) * | 1968-04-03 | 1970-07-28 | R & L Molecular Research Ltd | Basic esters of 5-alkanoylamino-3-(5'-nitrofur - 2' - yl)isoxazole - 4 - carboxylic acid |
GB1250219A (no) * | 1968-12-06 | 1971-10-20 | ||
US5968737A (en) * | 1996-11-12 | 1999-10-19 | The University Of Mississippi | Method of identifying inhibitors of glutathione S-transferase (GST) gene expression |
AU6909600A (en) * | 1999-08-13 | 2001-03-13 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-jun n-terminal kinases (jnk) and other protein kinases |
IL154710A0 (en) * | 2000-09-15 | 2003-10-31 | Vertex Pharma | Isoxazole derivatives and pharmaceutical compositions containing the same |
-
2002
- 2002-07-29 WO PCT/EP2002/008634 patent/WO2003013517A1/en not_active Application Discontinuation
- 2002-07-29 CN CNA028169395A patent/CN1549714A/zh active Pending
- 2002-07-29 IL IL15992602A patent/IL159926A0/xx unknown
- 2002-07-29 BR BR0211742-8A patent/BR0211742A/pt not_active IP Right Cessation
- 2002-07-29 PL PL02368403A patent/PL368403A1/xx not_active Application Discontinuation
- 2002-07-29 CA CA002455631A patent/CA2455631A1/en not_active Abandoned
- 2002-07-29 MX MXPA04000920A patent/MXPA04000920A/es unknown
- 2002-07-29 CZ CZ2004168A patent/CZ2004168A3/cs unknown
- 2002-07-29 NZ NZ530782A patent/NZ530782A/xx unknown
- 2002-07-29 EA EA200400289A patent/EA006769B1/ru not_active IP Right Cessation
- 2002-07-29 KR KR10-2004-7001848A patent/KR20040030941A/ko not_active Application Discontinuation
- 2002-07-29 AU AU2002342607A patent/AU2002342607B2/en not_active Ceased
- 2002-07-29 US US10/485,871 patent/US20050059657A1/en not_active Abandoned
- 2002-07-29 JP JP2003518526A patent/JP2005501073A/ja not_active Withdrawn
- 2002-07-29 EP EP02779257A patent/EP1435948A1/en not_active Withdrawn
-
2004
- 2004-01-16 ZA ZA2004/00347A patent/ZA200400347B/en unknown
- 2004-02-03 CO CO04008334A patent/CO5640104A2/es not_active Application Discontinuation
- 2004-02-03 NO NO20040511A patent/NO20040511L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1435948A1 (en) | 2004-07-14 |
WO2003013517A1 (en) | 2003-02-20 |
MXPA04000920A (es) | 2004-04-02 |
JP2005501073A (ja) | 2005-01-13 |
US20050059657A1 (en) | 2005-03-17 |
ZA200400347B (en) | 2005-03-30 |
KR20040030941A (ko) | 2004-04-09 |
CO5640104A2 (es) | 2006-05-31 |
CN1549714A (zh) | 2004-11-24 |
NZ530782A (en) | 2005-11-25 |
EA006769B1 (ru) | 2006-04-28 |
BR0211742A (pt) | 2004-08-24 |
EA200400289A1 (ru) | 2004-06-24 |
PL368403A1 (en) | 2005-03-21 |
AU2002342607B2 (en) | 2006-10-19 |
IL159926A0 (en) | 2004-06-20 |
CA2455631A1 (en) | 2003-02-20 |
CZ2004168A3 (cs) | 2004-05-12 |
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Legal Events
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FC2A | Withdrawal, rejection or dismissal of laid open patent application |