NL2029067B1

NL2029067B1 - Fluidic interface

Info

Publication number: NL2029067B1
Application number: NL2029067A
Authority: NL
Inventors: Krishna Ghatkesar Murali; Frederik Jacobus Van Altena Pieter
Original assignee: Univ Delft Tech
Priority date: 2021-08-27
Filing date: 2021-08-27
Publication date: 2023-03-15

Abstract

The invention provides a connection system (1) for connecting a tube (100) to a fluidic device (200), wherein the tube (100) in a relaxed state of the tube (100) comprises (i) a tube inner circumference (110) and (ii) a tube outer circumference (120) defining a tube wall (130), wherein the tube wall (130) is flexible; wherein the connection system (1) comprises (i) a tube connecter (10) comprising a connector outer circumference (12) and (ii) a securing element (20) comprising a securing element inner circumference (21), wherein the tube connector (10) is (i) fluidly connectable to a port (201) of the fluidic device (200), or (ii) is fluidly connected to the port (201) of the fluidic device (200), wherein the connection system (1) is configured for sealing the tube (100) at the tube connector (10) with the securing element (20), Wherein the connector outer circumference (12) is equal to or larger than the tube inner circumference (110) and wherein the securing element inner circumference (21) is equal to or larger than the tube outer circumference (120).

Description

P1690235NL00

Fluidic interface

FIELD OF THE INVENTION

The invention relates to a connection system for connecting a tube to a fluidic device. The invention further relates to a fluidic device comprising such connection system and a method for manufacturing the connection system.

BACKGROUND OF THE INVENTION

Interfaces between microfluidic chips and tubing are generally based on threaded or magnetic connections. A state-of-the-art threaded connection is for instance a luer-lock connection. The connection is often applied in medical and laboratory instruments and may provide a leak-free connection between a male-tape fitting and its mating female part. Another often applied connection is a ferrule type fitting, wherein the ferrule arranged around the tube, or wherein the ferrule is part of a nut. Many different configurations are on the market and basically follow the same principle: by screwing the fitting together, the ferrule may be compressed and deformed to keep the tubing in place

SUMMARY OF THE INVENTION

Microfluidics deals with fluid flow in microns size diameter channels. A microfluidic chip may consist of microchannels in glass, silicon, polymers, etc. These microchannels need an interface to connect with external devices, e.g. to provide the fluid to the channel (or discharge it from the channel). To facilitate connecting tubing to the channels, or tubing to tubing, different types of fittings, or interfaces may be used, such as the luer-lock connections and ferrule type fittings described above. These threaded types of connectors are rather large relative to the channel to which they are connected. Next to threaded type connectors, magnetic connectors may be applied. The magnetic connectors may be based on a first magnet with a fluid channel, a gasket, or an O-ring to be arranged over a port of the chip at the first side of the chip and a second (backing) magnet to be arranged at the opposite side of the chip to hold/attract the first magnet tightly to the chip.

These threaded and magnetic connectors may require a significant part of a surface of the chip and may have a large “footprint”, especially reducing a total number of connectors that may be configured at the chip or increasing the size of the chip. Furthermore, gluing 5S the connectors to the chip may even further increase the footprint. Prior art connectors may further comprise barbed connectors. Alternatively metal, especially stainless steel, piping connectors may be used. They may be pushed in, and glued to, the chip for slidably receiving the tubing over the piping.

Many connectors, appear to be prone for leakage, e.g. when not properly being glued to the chip or as a result of increased pressures in the microfluidic device.

Further, most barbed connectors, appear to require a high mounting force and may provide a large tube deformation (around the barb). Threaded connectors may further require free space to rotate the threaded parts. Threaded connectors need perfect matching of the threads. Further, preferably the fittings/connections allow a repeated use and a fast connection/disconnection which may not always be possible. Preferably, connecting, and disconnecting tubing to/from the chips is simple. Moreover, preferably, repeatedly connecting and disconnecting the tubing to/from the chip does not result in degradation or wear of the fitting/connection and/or the tubing.

Threaded connections may initially provide leak-free connections. Yet, the connection may slowly degenerate which may result in leakage. Moreover, ferrules may normally be used only a single time. Sliding connections, like barbed connections may require large tube deformations to withstand high operating pressures in the chip/tubing.

Hence, it is an aspect of the invention to provide an alternative connection system for connecting a tube (to a fluidic device or to another tube), which preferably further at least partly obviate(s) one or more of above-described drawbacks. It is a further aspect of the invention to provide an alternative fluidic device, which preferably further at least obviate(s) one or more of above-described drawbacks. The present invention may have as object to overcome or ameliorate at least one of the disadvantages of the prior art, or to provide a useful alternative.

In a first aspect, the invention provides a connection system for connecting a tube (or tubing). In embodiments, the connection system is configured for connecting the tube to a further tube. In further specific embodiments, the connection system is configured for connecting the tube to a fluidic device. The tube may especially be a flexible tube. The tube may in a relaxed state (or “uncompressed”, “unstrained”, especially not being deformed based on external forces) of the tube comprise (1) a tube inner 5S circumference and (ii) a tube outer circumference (together) defining a tube wall, especially a thickness of the tube wall. The tube wall may be flexible, in embodiments.

The tube wall is especially (reversibly) compressible (or deformable, especially resilient).

In specific embodiments, the connection system comprises a tube connecter. The connection system, especially, further comprises a securing element. In further embodiments, the tube connector is fluidly (and especially also sealingly) connectable to a port of the fluidic device. Additionally or alternatively, the tube connector may in embodiments be fluidly (and sealingly) connected to the port of the fluidic device. The tube connector may in further embodiments be fluidly (and sealingly) connectable to a further tube. The tube connector may further comprise a (tube) connector outer circumference. Further, the securing element may comprise a(n) (securing) element inner circumference. In further specific embodiments, the connection system is especially configured for sealing the tube at (around) the tube connector with the securing element.

In further specific embodiments, (a value of) the connector outer circumference is equal to or larger than, especially larger than, (a value of) the tube inner circumference. In specific embodiments, (a value of) the (securing) element inner circumference is equal to or larger than, especially larger than, (a value of) the tube outer circumference. Further, especially, the connection system may be configured such that (the value of) the (securing) element inner circumference is especially smaller than (a value of) a (strained) (outer) circumference of the tube being arranged around the tube connector. Further, especially, (the value of) the (securing) element inner circumference is larger than (the value of) the connector outer circumference.

In a further aspect, the invention provides a fluidic device comprising a connection system for connecting a tube, especially a flexible tube, to the fluidic device.

The connection system my in embodiments especially be configured for (connecting the tube to the fluidic device, wherein) a tube comprising a tube inner circumference and a tube outer circumference (in a relaxed state of the tube) (together) defining a tube wall,

especially wherein the tube wall is flexible. The connection system (of the fluidic device) may (thus) in embodiments be configured for connecting the tube described above (and also below) to the fluidic device. In further specific embodiments, the fluidic device comprises the connection system described above. In specific embodiments (of the fluidic device) the connection system comprises the tube connecter fluidly connected to a port of the fluidic device. In further embodiments (of the fluidic device) the connection system (also) comprises the securing element.

It is an aspect of the invention to provide a new type of connector interface mechanism for connecting tubing, especially to channels in a fluidic device, especially for connecting tubing to the microchannels. The invention especially provides a fluidic device and/or a connection system based on (comprising) the new type of connector interface.

The system may especially be less complex to use than prior art systems and may be smaller/require less space than prior art systems, which may be much bigger than the tube dimensions itself (especially threaded, magnetic an/or barbed systems).

Moreover, the connector size may in embodiments almost equal the tube outer dimension and may not require additional threading or magnets. Furthermore, the connection may be more durable than e.g. threaded connection of which the threads wear with time.

In embodiments a connecting tube/hose may simply be secured/compressed between the tube connector and the securing element. In specific embodiments the tube may be expanded from inside by the tube connector and compressed from outside by the securing element by sliding the elements together. The connection mechanism may in embodiments withstand at least 5 bars of pressure without leak. The tube connector and the securing element may in embodiment be fabricated by 3D printing or standard molding methods. The system may be suitable for any inner and outer diameter connecting (polymer) tube commercially available. The system may further be configured to connect from top, side, bottom, or edge. The connectors and/or fluidic devices comprising the connectors may in embodiments be 3D printed or produced by molding.

Hence, the invention provides in embodiments, a connection system for connecting a (flexible) tube to a fluidic device, wherein the tube, in a relaxed state of the tube, comprises (1) a tube inner circumference and (i1) a tube outer circumference (together) defining a tube wall, especially wherein the tube wall is flexible (especially

(reversibly) compressible (especially resilient)); wherein the connection system comprises (1) a tube connecter comprising a connector outer circumference and (ii) a securing element comprising a(n) (securing) element inner circumference, where in the tube connector is (1) fluidly (and sealingly) connectable to a port of the fluidic device, or

S wherein (i1) the tube connector is fluidly (and sealingly) connected to the port of the fluidic device, wherein the connection system is configured for sealing the tube at the tube connector with the securing element, wherein (a value of) the connector outer circumference is equal to or larger than (a value of) the tube inner circumference (in the relaxed state of the tube) and wherein (a value of) the (securing) element inner circumference is larger than (a value of) the tube outer circumference (in the relaxed stat of the tube). In further embodiments, the connection system may be configured such that (the value of) the (securing) element inner circumference is especially smaller than (a value of) a (strained) (outer) circumference of the tube being arranged at (around) the tube connector.

Further, the invention provides in embodiments, a connection system for connecting a (flexible) tube (to a further flexible tube), wherein the tube, in a relaxed state of the tube, comprises (i) a tube inner circumference and (i1) a tube outer circumference (together) defining a tube wall, especially wherein the tube wall is flexible (especially (reversibly) compressible (especially resilient)), wherein the connection system comprises (1) a tube connecter comprising a connector outer circumference and (ii) a securing element comprising a(n) (securing) element inner circumference, where in the tube connector is fluidly (and sealingly) connectable to a further flexible, wherein the connection system is configured for sealing the tube at the tube connector with the securing element, wherein (a value of) the connector outer circumference is equal to or larger than (a value of) the tube inner circumference (in the relaxed state of the tube) and wherein (a value of) the (securing) element inner circumference is larger than (a value of) the tube outer circumference (in the relaxed stat of the tube).

Further, additionally or alternatively, the invention may provide in embodiments, a fluidic device comprising a connection system for connecting a (flexible/resilient) tube to the fluidic device, wherein the tube in a relaxed (uncompressed) state of the tube comprises a tube inner circumference and a tube outer circumference

(together) defining a tube wall, especially wherein the tube wall is flexible (especially (reversibly) compressible (especially resilient)); wherein the connection system comprises (1) a tube connecter fluidly connected to a port of the fluidic device, wherein the tube connector comprises a connector outer circumference, and (ii) a securing element comprising an element inner circumference; wherein the connection system is configured for sealing the tube at (around) the tube connector with the securing element, wherein (a value of) the connector outer circumference is equal to or larger than (a value of) the tube inner circumference, and wherein (a value of) the (securing) element inner circumference is equal to or larger than (a value of) the tube outer circumference.

The connection described herein is especially based on arranging the tube around the tube connector and fastening or securing the tube at the tube connector with the securing element, especially wherein the tube wall is arranged between the tube connector and the securing element, and especially wherein the tube wall provides a sealed connection. During use of the connection system, the tube may in embodiments be expanded from inside by the tube connector and be compressed at the tube outer circumference by the securing element.

The invention may in an aspect relate to a connector interface for connecting a fluid circuit in a fluidic device to a fluid system external of the fluidic device.

The fluidic device may comprise a fluid channel inside the fluidic device. The fluid channel may especially comprise one or more ports for connecting to an external fluid system. The port may e.g. comprise an inlet port, or feed port, especially for feeding a fluid in a fluid channel fluidly connected to the port and/or comprising the port. The port may comprise an exit port or discharge port, especially for exiting or discharging fluid from a fluid channel comprising the port and/or fluidly connected to the port. In embodiments, the port may be used to provide fluid to the fluid channel and/or to discharge fluid from the channel.

The term “port” may especially refer to an opening to feed/and or discharge fluid from the fluid channel. In embodiments the tube connector is fluidly (detachably) connected to the port of the fluidic device. In further embodiments, the tube connector may be configured for fluidly connecting to the port of the fluidic device. A fluid provided to the tube connector may especially flow through the tube connector via the port in the fluid channel (when being connected to the fluidic device). Further, the connection may especially be a sealing connection, indicating that the connection does not leak; especially all fluid provided to the tube connector may end up in the fluid channel.

Herein, the term “port” may refer to a plurality of different ports. Further, the term “fluidic device” may especially refer to a microfluidic device. In embodiments, the fluidic device is especially a microfluidic device. Moreover, the term “fluid channel” may refer in embodiments to a microfluidic channel. Further, the term “connector interface” may refer to the connection system. The connector interface may be configured for connecting a tube or (“tubing”) to a microfluidic device. Moreover terms like “connecting to a fluidic device”, such as in the phrase “the connection system for connecting a tube to a (micro)fluidic device” may especially refer to connecting to a port of the fluidic device, especially a port fluidly connected to a fluid channel (and/or comprised by the fluid channel). Accordingly, this may also be indicated with phrases like “connecting the tube to a (micro) fluidic channel”, “connecting the tube (tubing) to an inlet (opening) of the fluid channel”, “connecting the tube to an outlet (opening) of the fluid channel”, “connecting the tube to an opening of the channel”, and e.g. “connecting the tube to (a channel comprised by) the fluidic device”.

Herein, the terms “channel” and “fluid channel” may be used interchangeably. The term especially refers to a fluid channel of the fluidic device, or e.g. a microfluidic channel of a microfluidic device. Furthermore, the term “channel” may refer to a plurality of different channels. The fluidic device may in embodiments comprise a plurality of fluid channels.

The securing element may be configured for enclosing at least part of a (outer) circumference of the tube, such as at least 50%, especially at least 70%, such as at least 80%, even more especially at least 90%. In specific embodiments, the securing element may be configured for enclosing substantially 100% of the circumference of the tube. The securing element may comprise an opening for hosting the tube. The securing element may in embodiments especially have a tube-like shape. In embodiments, the securing element e.g. comprise a cylindrical shape.

Especially, (a part of) the tube (especially comprising an end of the tube) may be locked by the tube connector and the securing element. Fastening may especially be based on compressing the tube between the tube connector and the securing element. In embodiments, a first force provided by the tube connector may act on an internal side of the tube wall (comprising the tube inner circumference) and especially a second force provided by the securing element may act in opposite direction on an external side of the tube wall (comprising the tube outer circumference). Based on these forces the tube wall may be compressed between the tube connector and the securing element. The connection system may especially be configured for compressible and/or flexible tubes, especially resilient tubes. The connection system may further especially be configured based on dimensions of the tube.

In embodiments, at least part of the tube connector and the tube may have a similar (geometrical) shape. In further embodiments, at least part of the securing element and the tube may comprise a similar shape. In yet further embodiments, at least part of the tube connector and (at least part of) the securing element may comprise a similar shape.

For instance, in embodiments, the tube is a circular (round) tube, and at least part of the tube connector is circular (e.g. comprising a cylinder shape) and at least part of the securing element is circular (e.g. ring shaped), see further below.

The term “tube” may especially refer to a tube, a hose, or a pipe configured for transporting a fluid through the tube, hose, pipe, etc. The term may further be indicated as “tubing”. The tube is especially flexible. The tube may e.g. in embodiments comprise a polymer tube. The tube may e.g. comprise (be made of) polyethylene, silicone, polypropylene, polyurethan, a fluoro polymer, latex, or nylon. Yet also other types of polymers are known to the skilled person.

The tube(s) may essentially comprise any arbitrary shape or cross-section (perpendicular to a -longitudinal- tube axis). The tube may e.g. comprise a rectangular, such as square, cross-section or a triangular cross-section. The tube may further especially comprise a circular cross-section. Moreover, especially the tube comprises a tube inner circumference and a tube outer circumference (together) defining the tube wall. Since the tube may be flexible and compressible, herein values of the tube inner circumference and the outer circumference may especially relate to values determined/defined in the tube comprising aa relaxed tube. Herein this may also be indicated with the term “in a relaxed state of condition of the tube”. The term especially indicates that no external forces may act on the tube (except e.g. from gravity) that may deform the tube. The tube especially is not strained, compressed, expanded and/or elongated in the relaxed state/condition.

Likewise, a thickness of the tube wall may relate to the thickness in a relaxed or not deformed state of the tube, unless indicated otherwise.

The term “circumference” may relate to perimeter or edge. The term may refer to the (physical) edge as well as to a total length of the edge. Based on the description it will be clear whether the term refers to a physical/tangible element, or to a length or distance along such physical/tangible element. For instance if a ratio of circumferences is indicated, this relates to a ratio of total lengths of the circumferences/edges. Yet, in phrases like “the outer circumference and the inner circumference define the tube wall” the term especially refers to the outer and inner edge (or surface) of the tube.

Further, the term “(value of) (securing) (element inner) circumference” especially refers to a total (closed) circumference. For instance, for a securing element configured for enclosing 90% of the outer circumference of the tube, (the value of) the securing element inner circumference may especially equal (the value of) the securing element inner circumference of a similar securing element configured for enclosing 100% of the circumference of the tube. Furthermore the term “value” in relation to a circumference may especially refer to a (total) length of/along the circumference.

In embodiments, the tube connector may be configured for (slidably) arranging inside (an end of) the tube, and the securing element may be configured for arranging slidably around the tube and to compress the tube wall between the tube connector and the securing element (especially at a securing location, see below), especially wherein the tube is in open fluid connection with the port of fluidic device.

For connecting the tube to the tube connector, the tube may in embodiments be slid over the tube connector. Therefore, in embodiments the connector outer circumference may be selected close to the tube inner circumference. In embodiments, the outer circumference of the tube connector (“connector outer circumference”) may be equal to or be (slightly) larger that the tube inner circumference. When arranging the tube around the tube connector, the tube may be stretched or expanded (and the actual tube wall thickness may be reduced). The tube may further be elongated. Yet in further embodiments, the connector outer circumference may be slightly (such as up to 30%, especially up to 20%) smaller than the tube inner circumference. In further embodiments, a ratio of (the value of) the connector outer circumference to (the value of the) the tube inner circumference (herein also indicated as “connector ratio”) may be at least 0.8, 5S especially at least 0.9, even more especially at least 1. The connector ratio may in embodiments be no more than 1.5, especially no more than 1.25, such as equal to or smaller than 1.2. Yet, in further embodiments, the connector ratio may be larger than 1.5, such as 2 at maximum, or even 3 at maximum, or especially even larger. The connector ratio may especially be selected based on an elasticity of material of the tube. At a higher 10 connector ratio a strain imposed on the tube (by the tube connector) is especially higher than at a lower connector ratio. The maximal connector ratio may essentially be selected to impose a strain under a tearing limit (strain at fracture/tearing) of material of the tube.

The connector ratio may in further embodiments selected to be smaller than the connector ratio at tearing of the tube. The connector ratio may especially be selected in the range of 1-3, such as 1-2, especially 1-1.5.

In specific embodiments, the tube connector is configured for receiving a (round) tube having a circular cross-section. The tube may comprise a tube outer diameter and a tube inner diameter (especially wherein a value of these diameters is defined in the relaxed condition of the tube). A ratio of the tube outer diameter and the tube inner diameter may be highly variable. In embodiments, said ratio may e.g. be around 1.1. Yet, in further embodiments, said ratio may be 5, 10, or even higher. The tube inner diameter and the tube outer diameter may define the tube wall width (or “tube wall thickness”) in embodiments. The tube wall width may thus also be highly variable and may e.g. depend on an elastic modulus of the tube material. The tube connector may in embodiments (also) comprise a circular cross section, especially comprising a connector outer diameter. In embodiments, the connector outer diameter may be selected close to the tube inner diameter. In embodiments, the connector outer diameter may be equal to or (slightly, such as up to 30%, especially up to 20%) larger that the tube inner diameter. Yet in further embodiments, the connector outer diameter may be 1.5, such as 2 at maximum, or even 3 times larger than the tube inner diameter. In further specific embodiments, the connector outer diameter may be slightly smaller than the tube inner diameter. In further embodiments, (a value of) a ratio of the connector outer diameter to the tube inner diameter may be equal to the value as described herein in relation to the connector ratio.

The ratio of the connector outer diameter to the tube inner diameter may especially be selected in one of the ranges described herein in relation to the connector ratio.

In embodiments, the connection system may be configured for connecting the tube to a further tube. Properties/characteristics, such as shape, dimensions, material, etc. of the further tube may in embodiments correspond to the properties/characteristics described herein in relation to the tube. The tube and the further tube may in embodiments e.g. have the same tube circumference and the same wall thickness. Yet in alternative embodiments the tube circumference of the further tube may e.g. differ from the tube circumference of the tube. In embodiments, the tube connector is configured for connecting at least two tubes fluidly (and sealingly) to each other. In further specific embodiments, the tube connector comprises a monolithic structure. The tube connector may e.g. comprise a fluid flow splitter (and may, e.g., comprise a T-shape or Y-shape for connecting two further tubes to the tube). The term “further tube” may refer to a plurality of further tubes. Likewise, the term “securing element” may refer to a plurality of securing elements (especially each securing element being configured for securing a respective tube at the tube connector).

The tube connector may further especially comprise a first (tube) connector portion configured for receiving the tube. The tube connector may further comprise a second (tube) connector portion configured for connecting to the port of the fluidic device.

In further embodiments, the tube connector may comprise at least two first (tube) connector portions (for receiving the tube and the further tube(s), respectively). The term “first (tube) connector portion” may refer to a plurality of (different) first (tube) connector portions. The plurality of first tube connector portions are especially fluidly (and sealingly) connected to each other.

Further, the term “tube” may relate to a plurality of tubes, especially to the tube and one or more further tubes. The term “tube” in relation to tube characteristics, e.g. the tube diameter, the tube shape, the tube outer circumference, the tube material, the tube wall, etc. may especially also refer to the (one or more) further tube(s).

The second tube connector portion may in embodiments be embedded in the fluidic device. In embodiments, the dimensions described herein in relation to the circumference of the tube connector, or e.g. in relation to the diameter of the tube connector especially refer to dimensions of the first tube connector portion(s). The dimension may especially relate to a predetermined (securing) location (or region) at the tube connector, especially at the first connector portion. The dimensions may change along a (longitudinal) tube connector axis. The dimensions may in embodiment especially change along a first (longitudinal) axis of the first connector portion (herein also indicated as a “first tube connector axis”).

In specific embodiments, the tube connector, especially the first tube connector portion may comprise a cylinder shape. In further embodiments, the tube connector may comprise a tapered shape. The tapered shape may especially be configured for tapering in a direction extending from the fluidic device. The tapered shape may facilitate sliding the tube (and/or further tube) over the tube connector. Hence, in embodiments, the tube connector outer circumference, or e.g. the tube connector outer diameter may increase in a direction towards the second tube portion, especially over at least part of the first tube portion. In further embodiments, the tube connector outer circumference, or e.g. the tube connector outer diameter may increase in a direction away from an extreme of the tube connector. In further specific embodiments, the first tube connector portion may comprise a tapered shape. Herein the term “tapered”, and comparable terms especially refers to becoming narrower, or reducing is size, especially in cross-sectional area, or outer circumference). The tube connector may further comprise a combination of a circular-cylinder shape and a tapered shape. For instance, the cylindrical shape may in embodiments taper, especially at an extreme of the tube connector (comprising the first connector portion). In embodiments, the tube connector may at least comprise the circular cylinder shape at the securing location (region) (see further below).

In further embodiments the tapered part may comprise the securing location.

Further, in embodiments, the tube connector, especially the first tube connector portion, may have a smooth surface. In embodiments, the surface may, e.g, have a Roughness value (Ra) equal to or than less 100 um, such as equal to or less than 50 um, such as equal to or less than 25 um, or equal to or less than 10 um. The Roughness value may e.g. be determined according to the ISO 4287:1997 standard. The surface may in embodiments essentially not comprise a rim or a barb or a bumpy, irregular, rough or non-uniform surface. In alternative embodiments, the surface may comprise a rim, a barb, or a bumpy, irregular, rough or non-uniform surface.

Hence, in embodiments the tube connector comprises a smooth outer surface, especially having a Roughness value (Ra) equal to or than less 50 um (according to an ISO 4287:1997 standard).

The tube connector may further be rigid, stiff and/or inflexible. The tube connector may e.g.be made of a substantially inelastic connector material. The tube connector may in further embodiments configured inflexible (e.g. having a thickness to provide a rigid character of the tube connector). In embodiments, an elastic modulus of the tube connector is larger than an elastic modulus of the tube. In embodiments, the connector material may comprise a polymer, such as polydimethylsiloxane (PDMS). In further embodiments, the connector material may comprise poly (lactic acid) (PLA). In further embodiments, the connector material may comprise a photo-curable polymer and/or a (negative) photoresist. The connector material may comprise a photo-resin. The connector material may further comprise a mixture of acrylated monomers and acrylated polymers. In yet further embodiments, the connector material may comprise poly (methyl methacrylate) (PMMA). Yet, further connector material may comprise polyethylene (PE), acrylonitrile butadiene styrene (ABS), or, e.g., polyethylene terephthalate (PET).

Additionally, or alternatively, the connector material may comprise Poly U (a UV absorbing polymer). In further embodiments, the connector material may comprise a thermoplastic elastomer (TPE) and/or a thermoset polyester. In yet further embodiments, the connector material may comprise polystyrene (PS), a Cyclic Olefin Copolymer (COC), or Polytetrafluoroethylene (PTFE). The connector material may especially comprise a thermosetting polymer and/or a photo-curable polymer, especially an UV-curable polymer. Additionally or alternatively, the connector material may comprise a thermoplastic polymer.

The term “thermosetting polymer” especially refers to a polymer that may be obtained by irreversibly hardening ("curing") a soft solid or viscous liquid prepolymer (or resin). Curing may be induced by heat (“heat or thermo setting”) or suitable radiation

(such as UV) (“photo-curable™). The term “thermoplastic polymer” especially refers to a thermo-softening plastic; a plastic polymer material that becomes pliable or moldable at a certain elevated temperature and solidifies upon cooling.

In further embodiments, the connector material may comprise a metal, e.g. 5S aluminium, stainless steel, copper, zinc, chromium, iron, or a combination (alloy) of metals. In yet further embodiments, the connector material may comprise glass or fused silica.

The term “connector material” may in embodiments refer to a combination (or a mixture) of connector materials described herein.

The tube connector may in embodiments be manufactured by mechanical machining. In further embodiments, the tube connector may be manufactured using selective laser etching. The tube connector may in further specific embodiments, be manufactured using an additive manufacturing technique. In specific embodiments, the tube connector may be manufactured by 3D printing or stereolithography. In further embodiments, the tube connector may be manufactured using inkjet printing techniques.

In further embodiments, the tube connector may be manufactured using a molding technique. Examples of molding techniques that may be used are e.g. casting, or injection molding. Hence, the tube connector material may especially be selected for its processability in one or more of the above-described manufacturing methods. The tube connector may further especially be manufactured as a monolithic structure.

Hence, in embodiments, the tube connector is manufactured using 3D printing or using a molding technique. In further embodiments, the tube connector may be fluidly connected to the port of the fluidic device. The tube connector may, in embodiments, be part of at least part of the fluidic device. Moreover, in further specific embodiments, at least part of the fluidic device in comprising the tube connector may be manufactured simultaneously. The at least part of the fluidic device may especially at least comprise the port of the fluidic device. In further embodiments, (substantially) the entire fluidic device and the tube connector may form a single monolithic structure. Yet in further embodiments, the tube connector may e.g. be glued to (the port of) the fluidic device.

Hence, in further specific embodiments, the tube connecter forms a monolithic structure with at least part of the fluidic device. In specific further embodiments, the monolithic structure is manufactured using 3D printing or a molding technique.

In further embodiments, the tube connector may be part of the fluidic device and especially the tube connector and at least a part of a remainder of the fluidic device are manufactured by 3D printing or a molding technique.

The tube connector may in embodiments be (partly, especially at least part of the second tube connector portion) be embedded in the fluidic device. In further embodiments, the tube connector is detachably connected to the port of the fluidic device.

The tube connector may, e.g., comprise or be coupled to an interface comprising an O-ring or another kind of gasket or seal. In embodiments, such interface may be mounted on/coupled to the port of the fluidic device. Such detachable coupling may, e.g., allow changing a size and/or shape of the tube connector.

In embodiments, the tube connector, especially the tube connector axis may be configured perpendicular to a plane of the fluidic device. The first tube connector axis may especially be configured parallel to, especially coinciding with, a (longitudinal) axis of the second connector portion (herein also indicated as a “second tube connector axis”), or an axis of the channel. Yet, it may further be advantageous to provide the tube to the tube connector under another angle with the plane of the fluidic device, or e.g. parallel to the plane of the fluidic. The tube connector may, in embodiments, essentially be connected or connectable to a port of the fluidic device under any arbitrary angle. The tube connector may in embodiments, e.g., be connectable (connected) to the fluidic device from one or more of a top of the fluidic device, a bottom of the fluidic device, a side of the fluidic device, and an edge (especially over any angle) of the fluidic device.

It may be advantageous in embodiments, to provide the tubes to one or more tube connectors connected to an inlet port from one side of the fluidic device, and the provide tubing to one or more tube connectors connected to an outlet port, from another side of the fluidic device. This may e.g. further be realized by configuring the first tube connector axis at an angle with respect to the second tube connector axis. The term “angle” herein may especially relate to an oblique angle as well as to a straight angle. In embodiments, the angle a is at least 45°, such as at least 60°, even more especially at least 90°. In yet further embodiments, the angle a may be smaller than 45°, such as in the range of 0-45°. The angle a is especially equal to or smaller than 180°. In specific embodiments, 0<a<180°, especially 45<a<180°, such as 60<a<180°, such as 90<u<180°. The first tube 5S connector may e.g. comprise a U-shaped configuration, wherein the angle may be 0° (or 360°). The first tube portion and the second tube portion may in embodiments extend in a same direction.

Hence, in further embodiments, the tube connector comprises (i) a first tube connector portion, configured for receiving the tube and defining a first (longitudinal) tube connector axis and (11) a second tube connector portion, configured for connecting to the port of the fluidic device and defining a second (longitudinal) tube connector axis, wherein the first tube connector axis and the second tube connector axis define an angle.

The securing element is especially configured for maintaining/securing the tube (and/or further tube(s)) around the tube connector. The element may be configured for compressing/sealing the tube at the (surface of) the tube connector. The securing element is in embodiments configured for arranging at a location/region of (especially around) the first tube portion (comprising the tube). The location/region (configured for) comprising the securing element securing the tube at the tube connector may herein also be indicated as the securing location or securing region. The securing location may especially be defined in relation to a longitudinal position of the tube connector. The securing location/region may refer to a location/region surrounding said longitudinal position. Therefore, herein the securing location may be indicated with respect to the tube connector, but also in relation to the tube and/or in relation to the securing element. Hence, in embodiments, the tube connector may comprise a plurality of securing locations, especially wherein each first tube connector portion comprises one securing location.

Herein the term “securing element”, and features of the securing element may also be referred to with the term “element” (only). Based on the description it may be clear when “element” refers to the securing element or wherein the term refers to any element/part or e.g. component.

The securing element may in embodiments be slid over the tube (and/or further tube) to secure the tube (and/or further tube) to the tube connector. The securing element may further, in embodiments, be slid over the tube in the relaxed condition.

Therefore, in embodiments the inner circumference of the securing element (herein also indicated as “(securing) inner element circumference”) may be selected close to the tube outer circumference (including the further tube outer conference). In embodiments, the 5S (securing) element inner circumference may be equal to or (slightly, such as up to 30%, especially up to 20%) larger that the tube outer circumference. Yet in further embodiments, the element inner circumference may be slightly (such as up to 30%, especially up to 20%) smaller than the tube outer circumference (in the relaxed condition of the tube). In further specific embodiments, a ratio (of the value) of the (securing) element inner circumference to (the value of) the tube outer circumference (also indicated as “(securing) element ratio) may be (selected to be) at least 0.8, especially at least 0.9, even more especially at least 1, such as larger than 1. The (securing) element ratio may in embodiments be no more than 1.5, especially no more than 1.25, such as equal to or smaller than 1.2. The element ratio may especially be selected in the range of 0.8-1.25, suchas 0.9-1.25, especially 1-1.25. Yet, in further embodiments, the element ratio may be larger than 1.5, such as 2 at maximum, or even 3 at maximum, or even larger. The element ratio may especially be selected based on an elasticity of material of the tube (and/or further tube) and an elasticity of the securing element.

The element ratio may further especially be selected based on the connector ratio (especially an amount of expansion of the tube). In further specific embodiments, the connector ratio is equal to or larger than 1, and especially the (securing) element ratio is (equal to or) larger than 1.

Further, in embodiments, the (respective) connector outer circumference is larger than the (respective) tube inner circumference, and especially during use, the securing element inner circumference (or inner diameter) is smaller than a (strained) outer circumference of the tube (or a strained outer diameter of the tube) (when being) arranged at (around) the tube connector. In embodiments, a ratio of (the value of) the securing element inner circumference to (a value of) the (strained) (outer) circumference of the tube (when being arranged around the tube connector) may define a tube ratio. The connection system may especially be configured for providing the tube ratio smaller than 1. The tube ratio may further especially be at least 0.5, such as at least 0.7, e.g. in the range of 0.5-

0.99, especially 0.7-0.99. The (strained) (outer) circumference of the tube is especially defined for the tube being expanded by the tube connector in the absence of the securing element.

In further embodiments, the tube connector and the securing element may be configured to provide a tube wall thickness in the strained or expanded state of the tube (and/or further tube) (at the securing region) being equal to or larger than 10% of the wall thickness in the relaxed state of the tube, and especially smaller than 100% of the wall thickness in the relaxed state of the tube, e.g. in the range of 0.1-0.99, especially 0.2-0.99, such as 0.5-0.99, or e.g. 0.5-0.95. The wall thickness in the strained (or expanded) state of the tube is especially defined for the tube being expanded by the tube connector in the absence of the securing element

In specific embodiments, the securing element may (also) comprise a circular cross section, especially comprising an element inner diameter. The securing element may comprise a ring shape or an open cylinder shape, in embodiments. In embodiments, the element inner diameter may be selected close to the tube outer diameter.

In embodiments, the element inner diameter may be equal to or (slightly, such as up to 30%, especially up to 20%) larger that the tube outer diameter. Yet, in further embodiments, the element inner diameter may be slightly smaller than the tube outer diameter. In further embodiments, (a value of) a ratio of the (securing) element inner diameter to the tube outer diameter may be equal to the value as described herein in relation to the (securing) element ratio.

Hence, in specific embodiments, the element inner circumference is equal to or larger than, especially larger than, the tube outer circumference. Further, especially, the connector outer circumference is equal to or larger than, especially larger than, the tube inner circumference. In further specific embodiments, tube connector and the securing element have a circular cross section, wherein (in the uncompressed state of the tube), the tube comprises an inner diameter and an outer diameter, wherein the tube connector comprises a connector outer diameter, and wherein the securing element comprises an element inner diameter, the connector outer diameter is equal to or larger than, especially larger than, the tube inner diameter and the element inner diameter is equal to or larger than, especially larger than, the tube outer diameter. Further, especially a difference between the element inner diameter and the connector outer diameter may be selected smaller than two times a thickness of the tube wall (in the relaxed state of the tube), e.g. 5-49% of the thickness of the tube wall, especially 15-49%, such as 25-49%, even more especially 25-45% of the thickness of the tube wall.

Further, the securing element may in embodiments be less rigid or stiff then the tube connector. The securing element may in embodiments be elastic. The securing element may especially be (configured) more rigid (less flexible) than the tube. In further embodiments, an elastic modulus of the securing element is larger than an elastic modulus of the tube.

The securing element may, in embodiments, be made of a polymeric material (“element material”). The securing element may in further embodiments configured inflexible (e.g. having a thickness or comprising an element material to provide a rigid character of the securing element). In embodiments, the securing element may e.g. comprise a metal element material or a rigid polymeric material. The securing element may in embodiments, especially, be flexible. In embodiments, the element material may comprise a polymer, such as polydimethylsiloxane (PDMS). In further embodiments, the element material may comprise a thermosetting polymer and/or a photo-curable polymer, especially an UV-curable polymer. Additionally or alternatively, the element material may comprise a thermoplastic polymer. The element material may in further embodiments, comprise a metal, a glass, or e.g. a fused silica. Further especially, the element material may comprise a material described herein in relation to the tube connector material. In further specific embodiments, the securing element may be manufactured using 3D printing or using a molding technique. In further embodiments, the securing element may be manufactured using machine tooling or mechanical machining.

The term “securing element material” may refer to a plurality (or combination) of (different) securing element materials.

Hence, in embodiments, the tube connector comprises a tube connector material, and the securing element comprises a securing element material, wherein the tube connector material and the securing element material are independently from each other selected from the group of polymers consisting of thermosetting polymers, photo- curable polymers, and thermoplastic polymers.

The securing element may especially (seal and) compress the tube between the securing element and the tube connector at the securing location. In embodiments, the securing element may comprise a circular round shape. The securing element may comprise a ring shape or e.g. a cylindrical ring shape. Further, the securing element may 5S further be configured to ease sliding of the securing element over the tube to the securing location. In embodiments, the securing element may (also) comprise a tapered (or cone- like / narrowing) shape, especially to facilitate sliding and securing. In embodiments, e.g, an inner size or dimension of the securing element may change over a length of the securing element (perpendicular to the opening in the securing element). The securing element may e.g. have a truncated cone shape. Such truncated cone or comparable shapes may especially be slid over the tube starting from the largest inner size, to gradually increase the compression on the tube when arranging the securing element. In further embodiments the inner size/dimension of the securing element may be substantially constant, and the outer size may (gradually) increase over the length of the securing element.

Further, a thickness (of a wall) of the securing element may change over the length of the securing element. In such configuration, the increased outer size may provide less flexibility compared to a location with a smaller outer size. Hence in embodiments the flexibility of the securing element may change over the length. The less flexible parts may provide an increased compression to the tube. Such tapered shape securing element may e.g. be slid over the tube starting from the smallest outer size of the securing element, to gradually increase the compression on the tube when arranging the securing element. The tapered shape (of the securing element) may in embodiments be configured for tapering in a direction towards the fluidic device. The tapered shape (of the securing element) may in further embodiments be configured for tapering in a direction away from the fluidic device.

Hence, in further embodiments one or more of the tube connector and the securing element comprises a tapered shape. In further embodiments, one or more of the tube connector and the securing connector comprises a(n) (open) cylindrical shape. For instance, in embodiments, (an extreme of) the tube connector may comprise a tapered shape (especially in combination with a cylindrical shape) and the securing element may comprise a cylindrical ring shape.

As discussed above, the tube connector may in embodiments be manufactured by 3D printing or stereolithography. The tube connector may further be 5S manufactured by molding, such as casting or injection molding. The tube connector may be manufactured using mechanical machining, or machine tooling. Also the securing element may in embodiments be manufactured by 3D printing or stereolithography. The securing element may further be manufactured by molding, such as casting or injection molding.

Hence, in a further aspect, the invention provides a method for manufacturing the connection system. The method may especially comprise a manufacturing method described above (e.g. inkjet printing, mechanical machining, 3D printing, injection molding, casting, etc.) (for the tube connector and/or the securing element). The method may especially comprise 3D printing or molding one or more of the tube connector and the securing element. Especially, the tube connector is manufactured by 3D printing or molding and the securing element is manufactured by 3D printing or molding. In embodiments, the method comprises 3D printing or molding at least part of a fluidic device comprising the tube connector, especially as a single monolithic structure.

The tube connector may in embodiments be manufactured from a connector material described herein. Further, the method may especially provide the tube connector and/or the securing element comprising characteristics (such as shape, dimensions, etc.) described above in relation to the connection system.

In further embodiments, the method may comprise manufacturing one or more of the of the tube connector and the securing element by stereolithography.

The embodiments described above in relation to the connection system of the present invention, may especially also apply for the device of the invention. Further, embodiments described in relation to the devices of the invention may also apply for the method of the invention.

BRIEF DESCRIPTION OF THE DRAWINGS

Embodiments of the invention will now be described, by way of example only, with reference to the accompanying schematic drawings in which corresponding reference symbols indicate corresponding parts, and in which: Figs 1A-4 schematically depict embodiments and aspects of a connection system of the invention.

The schematic drawings are not necessarily to scale.

DETAILED DESCRIPTION OF THE EMBODIMENTS

Figs 1A and 1B schematically depict embodiments of the connection system 1. In the embodiment, the connection system 1 is configured for connecting a (flexible) tube 100 to a (micro) fluidic device 200. In the figure the fluidic device 200 is very schematically depicted by the dotted lines. Therefore, the figure may also depict a (micro) fluidic device 200 comprising the connection system 1. The connection system 1 comprises a tube connecter 10 and a securing element 20. In the depicted embodiment in

Fig. 1A, the connecting system 1 is configured at a top of the fluidic device 200. In the embodiment of Fig 1B, the connection system 1 is configured at a side of the fluidic device 200. Yet in further embodiments, the connection system may be arranged at a bottom, or, e.g., under an angle at an edge of fluidic device 200, see also Figs 4. In further embodiments (not depicted), the connection system 1 may be configured for connecting the tube 100 to one or more further tubes 100. Essentially, this may be pictured by exchanging the depicted fluidic device 200 in the figures with one or more further tube connectors 10 (fluidly connected to the tube connector 10. depicted in the figures) and securing elements 20. In the later embodiments, the system 1 is especially configured to connect tubing 100 to other tubing 100. For instance, two tube connectors 10 on opposite sides or a T splitters /junction may be configured to connect two or more tubes 100.

Herein, the connection system 1 may especially be explained based on the depicted embodiments (for connecting to the fluidic device 200). It will be clear that in embodiments for connecting tubing 100 to tubing 100, the explained connection may be related to all connections of the plurality of tubes 100 to the system 1. Moreover, a fluidic network may comprise a combination of different systems 1, especially fluidically connected to each other.

In Fig. 1A, the tube 100 is depicted in the relaxed or uncompressed state of the tube 100 and comprises a tube inner circumference 110 and a tube outer circumference 120, together defining the tube wall 130. The tube wall 130 is especially flexible (and/or compressible). In Fig. 1B, the tube 100 is arranged around the tube connector 10 and is expanded by the tube connector 10 as is indicated by the strained outer circumference 125 of the tube 100, which is larger than the relaxed outer circumference 120 of the tube 100.

The strained outer circumference 125 is especially defined when the tube 100 is expanded or strained by the tube connector 10, in the absence of the securing element 20. When the securing element 20 is arranged over the tube 100, and together with the tube connector 10 encloses the tube 100, the tube 100 may be compressed by the securing element 20, which may result in a reduction in the outer circumference of the tube 100 at the securing location 16 again (not depicted in the figure).

The tube connector 10 may be fluidly connected to the port 201 of the fluidic device 200. It is noted that for clarity reasons, the fluidic device 200 in Figs 1 are only very schematically depicted, and also the channel 209 is not shown in the figures (a channel 1s very schematically depicted in Fig. 2 and Fig. 4). In other embodiments, see e.g. Fig. 3, the tube connector 10 is fluidly connectable to a port 201 of the fluidic device 200. In Fig. 1A also the outer circumference 12 of the tube connector 10 is depicted. The ratio of the connector outer circumference 12 to the tube inner circumference 110, herein also indicated as “connector ratio” is in embodiments selected to be smaller than 1. The connector ratio may especially be larger than 1, indicating that the tube 100 may be expanded when being slid over the tube connector 10. The tube connector 10 may especially be made of a tube connector material 19 such as a thermosetting polymer, a photo-curable polymer, or a thermoplastic polymer. Yet, other materials are also possible, for instance a glass, fused silica, or a metal.

The securing element 20 is especially configured for securing the tube 100 at the tube connector 10. Therefore, a ratio of the element inner circumference 21 to the tube outer circumference 120 (“securing element ratio”) may in embodiments be selected in the range of 0.8-1.2. The securing element ratio may especially be at least 1. This may especially allow to slide the securing element 20 over the tube 100 in the relaxed state.

The securing element 20 may be made of a securing element material 29, especially a polymer, such as e.g. also described in relation to the tube connector 10 or, e.g. a metal.

The figures further depicts that the element inner circumference 21 is larger than the tube outer circumference 12, and the connector outer circumference 12 is larger 5S than the tube inner circumference 110. Moreover, in the depicted embodiments, the tube connector 10 and the securing element 20 both have a circular cross section.

In Fig. 1A also the tube inner diameter 111 and tube outer diameter 121 (in the relaxed state) are depicted. Further, the tube connector outer diameter 11, and the element inner diameter 23 are shown. In the embodiment, the connector outer diameter 11 is larger than the tube inner diameter 23 and the element inner diameter 23 again is larger than the tube outer diameter 121.

When the tube connector 10 is arranged inside the tube 100, the securing element 20 may especially be slidably arranged around the tube 100 and as such may compress the tube wall 130 between the tube connector 10 and the securing element 20.

This way the securing element 20 may seal the tube 100 to the tube connector 10. The connection may withstand high pressures, e.g. 5 bars. To lock the tube 100 between the securing element 20 and the tube connector 10, the elastic modulus of the securing element 20 may especially be selected larger than the elastic modulus of the tube 100.

Further, especially the elastic modulus of the tube connector 10 is selected to be larger than the elastic modulus of the tube100.

In the embodiment of Fig 1A, the tube connector 10 comprises a tapered shape, indicated with reference 13, especially to ease sliding the tube 100 around the tube connector 10. The tube connector 10 further also comprises a circular cylinder shape portion 14. Also, the tube connectors 20 in Figs 1A and 1B comprise a (open) cylindrical shape. During use, the securing element 20 may seal the tube 10 at the tube connector 100, especially at the securing location 16 or securing region 16. The securing location 16 may in the embodiment of Fig. 1A be provided at the cylindrical shaped portion 14 (see also

Fig. 1B). The tube connector 10 further also comprises a smooth outer surface 15.

In Fig. 2 some further aspects of the system 1 and the fluidic device 200 are depicted. The tube connector 10 may be manufactured using 3D printing or using a molding technique. Yet, in embodiments, e.g. depicted in Fig.2, the tube connecter 10 forms a monolithic structure 220 with at least part of the fluidic device 200. Also such monolithic structure 220 may easily be manufactured using 3D printing or a molding technique. Likewise, the securing element 20 may be manufactured using 3D printing or using molding. The connection system 1 may e.g. be manufactured with the method of the invention. Although not explicitly shown, the tube connector 10 in the embodiment is fluidly connected with an inlet port 201. Reference 209 depicts the fluid channel. It is noted that the channel 209 is very schematically depicted and basically may have any arbitrary shape and size (see also Fig. 4). Further, the securing element 20 of the embodiment comprises a tapered shape 13.

In Fig. 3, a further tube connector 10 is depicted. The tube connector 10 may in embodiments be configured as a straight connector. However, the connector 10 may also comprise an angle. The tube connector 10 may have a first tube connector portion 17, configured for receiving the tube 100 and a second tube connector portion 18, configured for connecting to the port 201 of the fluidic device 200. Especially, a first tube connector axis Al defined by the first tube connector portion 18 and a second tube connector axis A2, defined by the second tube portion 18 may define an angle a, such as e.g. between (and including) 0 and 180°. An angle of 0° may especially refer to a U- shaped tube connector 10, whereas an angle of 180° may refer to a straight tube connector 10.

In Fig. 4 some further embodiments of the connection system 1 are depicted. The embodiments may further depict embodiments of the fluidic device 200 and/or the monolithic structure 220. The figure depicts some configurations of the tube connector 10 relative to the fluidic device 200, e.g. wherein the tube connector is arranged at a bottom, or a side of the fluidic device, or wherein the tube connector is arranged under an angle of a plane of the fluidic device (200), indicating the versatility of the connection system 1.

The term “plurality” refers to two or more. Furthermore, the terms “a plurality of” and “a number of” may be used interchangeably

The terms “substantially” or “essentially” herein, and similar terms, will be understood by the person skilled in the art. The terms “substantially” or “essentially” may also include embodiments with “entirely”, “completely”, “all”, etc. Hence, in embodiments the adjective substantially or essentially may also be removed. Where applicable, the term “substantially” or the term “essentially” may also relate to 90% or higher, such as 95% or higher, especially 99% or higher, even more especially 99.5% or higher, including 100%. For numerical values it is to be understood that the terms “substantially”, “essentially”, “about”, and “approximately” may also relate to the range of 90% - 110%, such as 95%-105%, especially 99%-101% of the values(s) it refers to.

The term “comprise” also includes embodiments wherein the term “comprises” means “consists of”.

The term “and/or” especially relates to one or more of the items mentioned before and after “and/or”. For instance, a phrase “item 1 and/or item 2” and similar phrases may relate to one or more of item 1 and item 2. The term "comprising" may in an embodiment refer to "consisting of" but may in another embodiment also refer to "containing at least the defined species and optionally one or more other species".

Furthermore, the terms first, second, third and the like in the description and in the claims, are used for distinguishing between similar elements and not necessarily for describing a sequential or chronological order. It is to be understood that the terms so used are interchangeable under appropriate circumstances and that the embodiments of the invention described herein are capable of operation in other sequences than described or illustrated herein.

The devices, apparatus, or systems may herein amongst others be described during operation. As will be clear to the person skilled in the art, the invention is not limited to methods of operation, or devices, apparatus, or systems in operation.

It should be noted that the above-mentioned embodiments illustrate rather than limit the invention, and that those skilled in the art will be able to design many alternative embodiments without departing from the scope of the appended claims. In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim.

Use of the verb "to comprise" and its conjugations does not exclude the presence of elements or steps other than those stated in a claim. Unless the context clearly requires otherwise, throughout the description and the claims, the words “comprise”, “comprising”, and the like are to be construed in an inclusive sense as opposed to an exclusive or exhaustive sense; that is to say, in the sense of “including, but not limited to”.

The article "a" or "an" preceding an element does not exclude the presence of a plurality of such elements.

The invention may be implemented by means of hardware comprising several distinct elements, and by means of a suitably programmed computer. In a device claim, or an apparatus claim, or a system claim, enumerating several means, several of these means may be embodied by one and the same item of hardware. The mere fact that certain measures are recited in mutually different dependent claims does not indicate that a combination of these measures cannot be used to advantage.

The invention also provides a control system that may control the device, apparatus, or system, or that may execute the herein described method or process. Yet further, the invention also provides a computer program product, when running on a computer which is functionally coupled to or comprised by the device, apparatus, or system, controls one or more controllable elements of such device, apparatus, or system.

The invention further applies to a device, apparatus, or system comprising one or more of the characterizing features described in the description and/or shown in the attached drawings. The invention further pertains to a method or process comprising one or more of the characterizing features described in the description and/or shown in the attached drawings.

The various aspects discussed in this patent can be combined in order to provide additional advantages. Further, the person skilled in the art will understand that embodiments can be combined, and that also more than two embodiments can be combined. Furthermore, some of the features can form the basis for one or more divisional applications.

Claims

Conclusions

A connection system (1) for connecting a tube (100) to a fluid device (200), the tube (100) in a relaxed state of the tube S (100) (1) having a tube inner circumference (110) and ( ii) comprises a tube outer periphery (120) defining a tube wall (130), the tube wall (130) being flexible; wherein the connection system (1) comprises (i) a tube connector (10) comprising a connector outer periphery (12), and (ii) a fastening element (20) comprising a fastening element inner periphery (21); wherein - the tube connector (10) is (1) fluidly connectable to a port (201) of the fluidic device (200), or (i1) is fluidly connected to the port (201) of the fluidic device ( 200), - the connection system (1) is adapted to seal the tube (100) on the tube connector (10) with the fixing element (20), the connector outer circumference (12) being equal to or greater than the tube inner circumference (110 ) and wherein the fastener inner circumference (21) is equal to or greater than the pipe outer circumference (120).

The connection system (1) according to claim 1, wherein the element inner circumference (21) is larger than the tube outer circumference (120), and wherein the connector outer circumference (12) is larger than the inner tube circumference (110), and in use the fastener inner circumference (21) is smaller than a tensioned outer circumference (125) of the tube (100) fitted to the tube connector (10).

A connection system (1) according to any one of the preceding claims, wherein the pipe connector (10) is configured to be fitted into the pipe (100), the fastening element (20) being configured to be slidable about the pipe (100). installed and to compress the pipe wall (130) between the pipe connector (10) and the fastener (20).

A connection system (1) according to any one of the preceding claims, wherein the tube connector (10) and the fixing element (20) have a circular cross-section, the tube (100), in the non-compressed state, having an inner diameter (111) and a outer diameter (121), wherein the conduit connector (10) comprises a connector outer diameter (11) and the fastener (20) comprises an element inner diameter (23), the connector outer diameter (11) being greater than the inner diameter (121) of the conduit and wherein the fastener inner diameter (23) is greater than the outer diameter (121) of the tube.

A connection system (1) according to any one of the preceding claims, wherein one or more of the pipe connector (10) and the fastening element (20) has a tapered shape.

A connection system (1) according to any one of the preceding claims, wherein the tube connector (10) comprises a smooth outer surface (15).

A connection system (1) according to any one of the preceding claims, wherein a modulus of elasticity of the fastener (20) is greater than a modulus of elasticity of the pipe (100) and wherein a modulus of elasticity of the pipe connector (10) is greater than the modulus of elasticity of the tube (100).

A connection system (1) according to any one of the preceding claims, wherein the tube connector (10) is manufactured using 3D printing or using a molding technique.

A connection system (1) according to any one of the preceding claims, wherein the tube connector (10) forms a monolithic structure (220) with at least part of the fluidic device (200).

A connection system (1) according to any one of the preceding claims, wherein the tube connector (10) is manufactured using 3D printing or a molding technique.

A connection system (1) according to any one of the preceding claims, wherein the pipe connector (10) defines (i) a first pipe connector portion (17) configured to receive the pipe (100) and a first pipe connector axis (A1) and (i1 ) a second tube connector portion (18) configured to connect to the port (201) of the fluidic device (200) and defining a second tube connector shaft (A2), wherein the first tube connector axis (A1) and the second tube connector axis (A2) define an angle (a), where 0<a<180°.

A connection system (1) according to any one of the preceding claims, wherein the pipe connector (10) comprises a pipe connector material (19), and wherein the fastening element (20) comprises a fastening element material (29), the pipe connector material (19) and the fastening element material ( 29) are independently selected from the group of polymers consisting of thermosetting polymers, photocurable polymers and thermoplastic polymers.

A fluidic device (200) comprising a connection system (1) for connecting a tube (100) to the fluidic device (200), the tube (100) in a relaxed state of the tube (100) having a tube inner circumference (110 ) and a tube outer periphery (120) defining a tube wall (130), the tube wall (130) being flexible; wherein - the connection system (1) comprises: (i) a tube connector fluidly connected to a port (201) of the fluidic device (200), the tube connector (10) comprising a connector outer periphery (12), and (11) a fastening element (200) comprising an element inner periphery (21), - the connection system (1) is configured to seal the pipe (100) on the pipe connector (10) with the fastening element (20), the connector outer periphery (12) being equal to 1s at or greater than 1s than the tube inner circumference (110), and wherein the fastener inner circumference (21) is equal to or greater than the tube outer circumference (120).

The fluidic device (200) of claim 13, wherein the fluidic device is a microfluidic device.

A fluidic device (200) as claimed in any one of claims 13 to 14, wherein the tube connector (10) and the fastener (20) have a circular cross-section, wherein, in the non-compressed state, the tube (100) has a tube inside diameter ( 111) and comprises a tube outer diameter (121), the connector (10) comprises a connector outer diameter (11), and the fastener (20) comprises a member inner diameter (23), the connector outer diameter (11) being greater than the inner tube diameter (111) and wherein the element inner diameter (23) is greater than the tube outer diameter (121).

A fluidic device according to any one of claims 13 to 15, wherein the tube connector (10) forms a monolithic structure (220) with at least part of the fluidic device (200).

A fluidic device (200) according to any one of claims 13 to 16, wherein the connector (10) is releasably connected to the port (201) of the fluidic device (200).

A method of manufacturing the connection system (1) as defined in any one of claims 1-12, wherein the method comprises 3D printing and/or molding of one or more of the tube connector (10) and the fixing element (20) .