NL2009976C2

NL2009976C2 - Method and apparatus for assembly of intraocular lens with two optical elements.

Info

Publication number: NL2009976C2
Application number: NL2009976A
Authority: NL
Inventors: Aleksey Nikolaevich Simonov; Michiel Christiaan Rombach
Original assignee: Akkolens Int Bv
Priority date: 2011-12-12
Filing date: 2012-12-12
Publication date: 2014-03-24
Also published as: NL2009976A

Description

Method and apparatus for assembly of intraocular lens with two optical elements

An intraocular lens, an IOL, generally comprises two main components, firstly, at least one lens comprised of at least one optical element to provide for optical functions, to 5 modulate the light beam to provide for an image on the retina of the eye, and, secondly, at least one haptic, an anchor, to provide for mechanical functions, to anchor and position the lens in the eye.

In accommodating lenses the haptics generally also transfers movement of a component of the eye to focus the image on the retina, which focusing can be driven by, for 10 example, the ciliary muscle of the eye, which provides for movement of at least one optical element of the lens relative to, for example, perpendicular to, the optical axis, or, alternatively, provides for movement of at least one optical element of the lens along the optical axis, or, alternatively, provides for a change in the shape of at least one optical element of the lens.

15

One-piece IOLs, which can be monofocal IOLs or, alternatively, can be multifocal IOLs, consist of a single optical element which is the lens, generally of a foldable material, which lens is fitted with, at its circumference, at least one haptic. The lens and haptic are generally comprised of the same material, which IOLs can be manufactured 20 by lathing and milling from a single lens button, meaning a block, a piece, of semiproduct, or, alternatively, can be manufactured by molding in a cast from a liquid compound generally comprising a combination of monomers and additives.

Multi-piece IOLs, for example three-piece IOLs, which can be monofocal or, alternatively, can be multifocal IOLs, consist of a single optical element which is the 25 lens, generally of a foldable material, for example, an hydrophilic acrylate lens, which lens is fitted with, at its circumference, with, for example, two C-shaped, or, J-shaped, haptics from a different material, for example made from PMMA or polypropylene. The haptics are attached to the lens by glue, with positioning and gluing of the haptics to the lens being one of the last assembly steps of the IOL manufacturing process. Four 30 materials can comprise the haptic, C-loops or J-loopsloops, of three-piece lenses: PMMA (Perspex), polypropylene (Prolene), polyamide (Elastamide), and polyvinylidene fluoride (PVDF).

2

The following definitions will be used in the context of the present document: Polymer: a compound of high molecular weight derived from addition of many molecules forming chains; Elastomer: a material that returns to its original shape after folding; Acrylic resin: any of a group of thermoplastic resins formed by polymerizing the esters 5 of acrylic or methacrylic acid; Acrylics: polymers incorporating methacrylic or acrylic esters, including PMMA, hydrogels, and foldable acrylic; PMMA: poly-methylmethacrylate, a hydrophobic acrylic; Acrylic PMMA IOLs are acrylic in nature even though the term “acrylic IOL” has come to define a foldable IOL with an acrylic structure and a acrylics are composed of long-chain meth-acrylate and acrylate co-10 monomers (for example, 2-phenylethyl acrylate and 2-phenylethyl methacrylate), and it is hydrophobic, with a water content of less than 1%. Hydrophilic acrylic, also: hydrogels: polymers that swell in water and retain a significant amount of water in their hydrated structure. These co-polymers of meth-acrylate esters mostly consist of a hydrophilic co-monomer with a hydroxyl functional group such as HEMA of 6-15 hydroxyethyl methacrylate, also: HOHEXMA. The presence of this hydroxyl group is responsible for absorbing and retaining water. They may also include a second hydrophobic co-monomer such as methyl-methacrylate. The ratio of hydrophilic to hydrophobic co-monomers determines the water content of the hydrogel, and it may vary from 18% to 38%. HEMA: 2-hydroxyethylmethacrylate, also: poly-HEMA, a 20 hydrogel of high water content (38%). HOHEXMA: 6-hydroxy-hexyl-meth-acrylate combines with HEMA in some formulations. Combinations of HEMA, HOHEXMA, and 1, 6-hexane-diol-dimeth-acrylate. Elastamide is a poly-amide haptic structure which can be used in three-piece silicone optic IOLs. Silicones are silicone-oxygen chains comprising organic groups such as methyl or phenyl to form an 25 elastomer. Poly-siloxane with two methyl groups forms poly-dimethyl-siloxane and if the organic groups are two phenyl groups alternating with poly-dimethyl-siloxane the material is poly-dimethyl-di-phenyl-siloxane. All silicone materials are hydrophobic. UV blocker generally comprise benzophenone or benzotriazole groups.

30 Accommodating intraocular lenses, AIOLs, can comprise two optical elements which move along the optical axis during the accommodation process. Such AIOLs are disclosed in, for example, CA 2.752.046, of with some embodiments comprise a copolymer comprising an acrylate recurring unit and an optionally substituted vinylaryl recurring unit, wherein a portion of at least one of the recurring units comprises a vinyl- 3 dialkyl-siloxy pendant group. Such co-polymers may be useful as soft acrylic haptics for intraocular lenses. Other embodiments in the same document relate to IOLs with a hydrophobic soft acrylic optic and with a silicone haptic, such as a dual optic accommodative lens a having hydrophobic soft acrylic anterior and posterior optic 5 bodies and a silicone haptic. Note that, in the present document, examples of IOLs and AIOLs comprised of, generally combinations, of acrylates are carried forward to illustrate the principles of the present inventions, but that the inventions are not limited to these groups of chemical acrylate constituents.

10 Alternatively, polymers such as hydrophobic acrylics can comprise IOLs, with typical water content of less than 2%. Alternatively, polymers such as hydrophilic acrylics, also: hydrogels, or polymers which are combinations of said polymer constituents. The flexibility is the effect of the flexibility of the molecular chain, the inter-chain flexibility, and flexibility due to additives which can be additional co-polymers or 15 chemical groups, for example, hydroxyl groups, which bond to the molecular polymer scaffolding without said chemical groups polymerizing. For example, one IOL material comprises a co-polymer of hydrophilic acrylic material and porcine collagen as an additive chemical, leading to a material of 34% water content. Hydrophilic acrylic polymers comprise hydrophilic cross-linked polymers and water, do not dissolve in 20 water but swell in water to a stable state containing water in the range of 18-40%, depending on the constituents of the material. IOLs can be made from hydrophilic acrylates and co-polymers with hydrophilic groups, from hydrophobic acrylates and copolymers with hydrophobic groups, from silicones, and from perspex, PMMA . Hydrophilic acrylates, HAs, will be carried forward as examples in the present 25 document. HAs are water-insoluble, are absorbent and are flexible. The water content of HAs varies from 18% to 30%. Hydrogel acrylics are HAs made from poly-hydroxy-ethyl-methacrylate, p-HEMA, Acrylics are non-hydrogel HAs with a relatively low water content, and Hybrid acrylics usually incorporate HEMA to improve flexibility. The chemical p-HEMA is soft and flexible, is autoclavable, is Nd:YAG compatible and 30 is foldable, which allows small-incision surgery to implant the IOLs. The first hydrophilic IOLs were made of poly-(hydroxyl-ethyl-methacrylate) in the 1980’s, but later material with combinations of polymers were developed, for example, a combinations of the co-polymer of hydroxyl-ethyl-methacrylate, HEMA, and the copolymer of hydrophobic methyl-methacrylate, MMA. Such materials comprising 4 combinations of co-polymers have the desired water contents of 18-30%, are foldable, and have a higher refractive index than HEMA alone. In general an increased percentage of hydroxyl groups leads to increased hydrophilic properties of the material.

5 The method for manufacturing an IOL with at least two optical elements includes two main steps. Firstly, provision of the at least two optical elements, which process starts with a first liquid compound with the first liquid compound comprising a single monomer or, alternatively, and more generally, comprising a combination of at least two monomers and additives. This first liquid compound is polymerized to provide a 10 single polymer, in the case of a single monomer or, alternatively, a combination of copolymers for the optical elements, in the case of a combination of monomers. Secondly, provision of at least one connection between at least two optical elements, which optical elements are mutually connected at, at least one, connection face, meaning a component of the optical element adapted to provide the surface for the bond between the optical 15 elements, with at least one connection face on one optical element opposing a connection face on the other optical element. Each optical element comprises at least one connection face adapted to provide the bonding. So, the method comprises polymerizing of a first liquid compound, which liquid compound comprises a combination of at least one monomer, to provide the optical elements, connecting the 20 optical elements at opposing connection faces, with each optical element fitted with at least one connection face, dosing of a second liquid compound, which compound comprises a combination of at least one monomer, to at least one connection face of at least one optical element, and, positioning of at least two opposing connection faces such that said faces are in mutual contact, and, finally, polymerizing of the second 25 liquid compound to provide connection between the optical elements.

The present invention discloses a method to provide processing of a second liquid compound which is either the same as the first liquid compound, meaning that the constituents of the first liquid compound and the constituents of the second liquid 30 compound are the same. So, the method is adapted to provide processing of a first liquid compound and a second liquid compound of which the constituents are the same, or, alternatively, method is adapted to provide processing of a first liquid compound which comprises at least one additional additive compared to the second liquid compound.

5

Examples of materials for the first liquid compound and second liquid compound are as follows, for which the method can provide processing: The first liquid compound and the second liquid compound both contain the constituents hydroxyl-ethyl-methacrylate and methyl-methacrylate for a hydrophilic material, or, contain long-chain methacrylate 5 and acrylate co-monomers, for example 2-phenylethyl acrylate and 2-phenylethyl methacrylate for hydrophobic material, or, the first liquid compound and the second liquid compound both contain at least one polysiloxane compound, for example, poly-dimethyl-siloxane or poly -dimethyl-diphenyl-siloxane, for silicone materials.

10 Generally the chemical constituency of the first and the second liquid compound will be the same, resulting in a chemical constituency of the optical elements which is the same as the constituency of the connections of the optical elements. Such sameness eases production because the same material and same polymerization procedures can be used throughout the lens production and assembly, and such sameness strengthens the IOL or 15 AIOL construction because the sameness aligns the elasticity of the optical elements with the elasticity of the connections which prevents stresses in the lens, once in the eye, especially in such AIOLs of which optical elements move relative to each other. The second liquid compound can be a combination of at least one monomer from the first liquid compound which combination is adapted to provide a desired flexible 20 connection between said optical elements. So, in practice, the connection will likely contain either the same range of compounds, of monomers and additives, as do the optical elements, but the connection can contain a subset of the thereof, for example the connection can be comprised of only HEMA or, alternatively, only MMA, with additives deleted. For example, the first liquid compound and the second liquid 25 compound can both contain hydroxyl-ethyl-methacrylate and methyl-methacrylate, and, for example, the first liquid compound and the second liquid compound can both contain hydroxyl-ethyl-methacrylate and methyl-methacrylate in such relative percentages that the resulting polymer is a hydrophilic polymer, or, alternatively, the first liquid compound and the second liquid compound can both contain hydroxyl-ethyl-30 methacrylate and methyl-methacrylate in such relative percentages that the resulting polymer is a hydrophobic polymer.

Flexible acrylic polymers are created by cross-linking, and when different monomers are polymerized together, the process is called co-polymerization. Foldable acrylic lenses can comprise different copolymer acrylics, with different refractive indices, glass 6 transition temperatures, water contents and mechanical properties. Flexible, foldable, IOLs can comprise polymers such as silicones, polysiloxanes, for example poly-dimethyl-siloxane or poly -dimethyl diphenyl siloxane, all highly cross-linked. So, the method can be characterized in that the the first and second liquid compounds both 5 contain at least one polysilane compound resulting in a combination of co-polymers which is a silicone hydrophobic material.

The second liquid compound is applied to at least one connection face on at least one optical element, followed by positioning of the optical elements such that the 10 connection faces are in mutual contact, meaning direct contact, or, alternatively, are in near mutual contact, meaning at such close distance that the second liquid compound forms a bonding film, generally a capillary film, between the connection faces of the optical elements, followed by polymerization of said second liquid compound into a single polymer, or, alternatively, into a combination of co-polymers, depending on the 15 constituents of the second liquid compound. The first liquid compound and the second liquid compound can be comprised of a single monomer, but are generally combinations of, at least two, monomers which liquid compounds can be further enriched with additives. Such additives are chemical constituents which bind to the single polymer or, alternatively, to at least one of the polymers in the combination of polymers, and which 20 additives, for example, perform certain optical function, such as blocking, filtering, UV-light, as is the case in nearly all IOL materials today, or blocking, filtering, certain frequencies of blue light, as in the optional yellow materials, blue-light blocking IOL materials today. Note that such additives, for example the UV-blocking additive, are generally required to be included in the optical elements, but not necessarily required in 25 connections outside the optical area from which such additives can be safely excluded.

So, the first liquid compound and the second liquid compound can comprise the same monomers and additives, or, alternatively, the first liquid compound can comprises additional monomers and additives compared to the second liquid compound, or, 30 alternatively, the first liquid compound comprises a combination of at least two monomers and additives which differs from the combination of monomers and additives which is comprised in the second liquid compound.

7

The constituents of the first liquid compound and the second liquid compound can be the same, or, alternatively, the constituents of the first liquid compound and second liquid differ, for example, the first liquid can comprise at least one additional additive compared to the second monomer. Such additive can be a co-polymer or, alternatively, 5 can be a light blocking additive as discussed above, for example a UV-light or blue light blocking additive, or, alternatively, such additive can be any other constituent with any other function. Two classes of UV-absorbing chromophores can be included in IOL materials: benzotriazole and benzophenone. Also, IOLs that filter both UV and short wavelength visible violet and blue light have been introduced. A yellow chromophore is 10 incorporated into the IOL material, which represents an attempt to more accurately mimic the light transmission characteristics of the crystalline lens, also: light-normalized IOL materials.

The optical elements can be manufactured by mechanical means, meaning machining on 15 a machine tool, generally lathing and milling, starting with a polymerized block, a piece, of semi-product, for example a thickened disc, a button, of polymerized first liquid compound so the manufacturing by mechanical means starts with the first liquid compound indirectly. Note that machining is not restricted to only lathing and milling but that any other mechanical manufacturing processes are included. Alternatively, the 20 optical elements can be manufactured by chemical means, meaning molding, generally molding in a cast with the optical elements provided by polymerization of the first liquid compound in a mold, a mould, so molding generally starts with said liquid compound directly with the compound being poured and polymerized in the cavity of the mold and with the polymerization and molding steps occurring concurrently.

25

Polymerization of the first liquid compound can be initiated by any irradiation or radiation, such as UV-light or by IR irradiation, by heat, or by ultrasound, meaning radiation by sound, by vibration. For ease of processing of the assembly of the optical elements the polymerization of the second liquid compound is generally initiated by 30 irradiation of UV-light only, but not restricted thereto.

So, the method is adapted to provide, for example, an accommodating intraocular lens, or, alternatively, a multifocal intraocular lens, or, alternatively, a hitherto unpublished invention, an accommodating multifocal lens. All of these lenses comprise at least two 8 optical elements. The lens comprises at least two optical elements comprising at least one polymer of the first liquid compound, which optical elements are connected at opposing connection faces by a connection comprising at least one polymer of the second liquid compound. The IOLs and AIOLs comprise an assembly of at least two 5 optical elements of which the optical elements have such a shape such that only the combination of optical elements forms the lens with the intended optical functions such as, for example, refractive power and, for example, accommodative power. Firstly, accommodating lenses can have a combination of two optical elements which move relatively to each other in the eye. Only the combination of optical elements provides 10 the lens of the desired refractive power, meaning the optical power which focuses the eye at a distance when the driving means of accommodation are inactive, and only the combination of optical elements provides the desired variable focal power, meaning the optical power which focuses the eye at closer distances with the intended distance depending on the degree of activity of the driving means, which driving means can be, 15 for example, the ciliary muscle of the eye.

For AIOLs the optical elements can either move along the optical axis to accommodate, to change the focal distance of the lens, as in, for example, US2010.324.673 and W02010.054.255, in a Newtonian telescope or Galilean telescope optical design, or, 20 alternatively, the optical elements can move perpendicular to the optical axis to accommodate, to change the focal distance of the lens, as in, for example, US2010/0.094.413 and US 2009062912, or, alternatively, the optical elements can rotate relative to each other, as in, for example, AIOLs comprising two chiral optical elements, as in a hitherto unpublished patent application document, or adjustable 25 multifocal IOLs comprising at least two chiral optical elements, as in, for example, WO2011.102.719, which comprise a combination of two optical elements which move relatively to each other and which only the combination provides a lens of the desired multifocality, as in, for example, which discloses multifocal lenses of which the relative optical powers, at least two focal distances, are adjustable by rotation of at least two 30 optical elements relative to each other.

The apparatus for assembly of an IOL or AIOL with two optical elements, which elements comprise at least one polymer and each of which optical elements comprises at least a connection face, can comprise at least one fixation means for fixation of at least 9 one of the optical elements, and, at least one dosing means for applying the second liquid compound to at least one connection face of at least one of the optical elements, and, at least one manipulating means for manipulating at least one optical element to at least one position wherein at least one of its connection faces contacts the connection 5 face of the other optical element, and, the apparatus comprises at least one polymerization means for polymerizing said second liquid compound following said dosing of the second liquid compound and said positioning of at least one optical element. So, the apparatus is intended for manufacturing of an intraocular lens, with the lens comprising at least two optical elements, with the optical elements comprising a 10 combination of at least one polymer obtained by polymerizing a first liquid compound, and, with the lens comprising at least one connection between the optical elements with the connection comprising a combination of at least one polymer obtained from polymerizing a second liquid compound, characterized in that the apparatus comprises at least one fixation means for fixation of at least one of the optical elements, and, at 15 least one dosing means for applying the second liquid compound to at least one connection face of at least one of the optical elements, and, at least one manipulating means for manipulating at least one optical element to at least one position wherein at least one of its connection faces contacts said applied liquid compound on at least one connection face of at least one of the other optical elements, and, at least one 20 polymerization means for polymerizing said second liquid compound. So, the apparatus for manufacturing of an intraocular lens with the lens comprising at least two optical elements which elements made of at least one polymer and each of which elements comprises at least one connection face, wherein the apparatus comprises at least one fixation means for fixation of at least one of the optical elements, and, at least one 25 dosing means for applying the second liquid compound to at least one connection face of at least one of the optical elements, and, at least one manipulating means for manipulating at least one optical element to at least one position wherein at least one of its connection faces contacts said applied liquid compound on at least one connection face of at least one of the other optical elements, and, at least one polymerization means 30 for polymerizing said second liquid compound.

The fixation means of the apparatus can comprise a standardized industrial fixation component for semi-finished lens components, which stub is adapted to provide also fixation of the optical element for at least one machining tool. So, the fixation means 10 comprise a standardized industrial fixation component for semi-finished lens components, which fixation component is adapted to provide such that the component provides fixation of the optical element to the apparatus for assembly and to at least one machining tool.

5

The dosing means can include a dosing component, a precision extruder, comprising at least one combination of a barrel, plunger and needle adapted to provide dosing of the second liquid compound. So, the dosing means can include a precision extruder with the extruder comprising a combination of a barrel, plunger and needle adapted to provide 10 precise dosing of the second liquid compound.

The manipulation means can be adapted to provide precise positioning of the dosing means, meaning that the fixation means remain in a fixed position during the dosing process, or, alternatively, the manipulation means can be adapted to provide precise 15 positioning of the fixation means, meaning that the dosing means remain in a fixed position during the dosing process, or, alternatively, the manipulation can be adapted to position both the dosing means as well as the fixation means. The combination of manipulation means and dosing means can be adapted to provide a single drop of second liquid compound on at least one connection face, or, alternatively, the 20 combination can be adapted to provide a pattern, for example a string, of multiple single drops on the connection surface.

The polymerization means for polymerizing said second liquid compound preferably comprises UV-light irradiation polymerizing means because of the least complex 25 integration in the apparatus. Note the need of operating the apparatus in near dark conditions with such UV-polymerization to prevent partial polymerization of the second liquid compound by UV frequencies in ambient light. So, the polymerization means for polymerizing said second liquid compound can include at least one UV-light irradiation polymerizing means.

30

Figure 1. An example of an accommodating intraocular lens which, in this particular example, changes focus by shifting, at least one, of the optical elements in a direction perpendicular to the optical axis, a design set forth in, for example, US2010/0.094.413 and US 2009062912, with the optical elements, 1, and haptics, 2, with hinges, 3, with 11 said optical elements and haptics manufactured by polymerization of the first liquid, and the assembly of the lens by connection between the elements, 4, with said connections manufactured by dosing and polymerizing the second liquid.

5 Figure 2. An example of a multifocal lens which provides at least two fixed focal distances, a design set forth in, for example, WO2011.102.719, with the chiral optical elements, 5, and haptics, 6, in this example C-loop haptics, with the chiral elements partially rotated to separate the discrete zones, 8a, to provide the sectors, 7, 8, which in turn provide the two distinct lenses, with the optical elements arranged around a central 10 axis, 9, with said optical elements and haptics manufactured by polymerization of the first liquid, and the assembly of the lens by connection between the elements, 10, in this example four connections, with the connections manufactured by dosing and polymerizing the second liquid.

15 Figure 3. An example of an accommodating multifocal lens which provides at least two variable focal distances, according to a design set forth in an hitherto unpublished document, with the chiral optical elements, 5, rotatable by the eye over an angle, 11, around a central axis, 9, with the lens providing said two variable foci by the variable sectors 13, 14, with said optical elements manufactured by polymerization of the first 20 liquid, and the assembly of the lens by the, elastic, connection between the elements, 12, which said connection manufactured by dosing and polymerizing the second liquid, with the lens

So, in summary, the method for manufacturing and assembly of an intraocular lens 25 comprises at least two optical elements with the method comprising processing of two liquid compounds with polymerizing of a first liquid compound to provide the optical elements, with the first liquid compound comprising a first monomer; and, connecting the optical elements at mutually opposing connection faces, and, provision of dosing of a second liquid compound to at least one connection face of one of the optical elements 30 with the second liquid compound comprising a second monomer, positioning of said opposing connection faces such that said faces are in mutual contact, and, polymerizing the second liquid compound. So, in summary, The intraocular lens comprises at least two optical elements comprising at least two optical elements with the optical elements provided by polymerizing of a first liquid compound with the first liquid compound 12 comprising a first monomer, and, with at least one connection between the optical elements at mutually opposing connection faces, characterized in that connection is provided by dosing of a second liquid compound to at least one connection face of one of the optical elements with the second liquid compound comprising a second 5 monomer, and, positioning of said opposing connection faces such that said faces are in mutual contact, and, polymerizing the second liquid compound. So, in summary, the apparatus is disclosed for assembly of an intraocular lens, with the lens comprising at least two optical elements, with the optical elements comprising a combination of at least one polymer obtained by polymerizing a first liquid compound, and, with the lens 10 comprising at least one connection between the optical elements with the connection comprising a combination of at least one polymer obtained from polymerizing a second liquid compound, characterized in that the apparatus comprises at least one fixation means for fixation of at least one of the optical elements, and, at least one dosing means for applying the second liquid compound to at least one connection face of at least one 15 of the optical elements, and, at least one manipulating means for manipulating at least one optical element to at least one position wherein at least one of its connection faces contacts said applied liquid compound on at least one connection face of at least one of the other optical elements, and, at least one polymerization means for polymerizing said second liquid compound.

20

Claims

Method for manufacturing and assembling an intraocular lens consisting of at least two optical elements, the method comprising processing two liquid connections: - polymerization of a first liquid connection to obtain the optical elements, the first liquid compound consists of a first monomer; and - connecting the optical elements on opposite connecting faces, characterized in that the method is further tailored to: 10. supplying a second liquid connection to at least one connecting face of one of the optical elements, wherein the second liquid connection consists of a second monomer; - positioning said opposite connecting surfaces such that these surfaces make contact with each other; and 15. polymerization of the second liquid compound.

The method according to claim 1, characterized in that the first liquid compound and the second liquid compound are identical.

The method as postulated in claim 1, characterized in that the second monomer and the second monomer are identical.

4. The method according to claim 1, characterized in that the first liquid compound contains at least one additional additive compared to the second liquid compound.

The method according to any of the preceding claims, characterized in that the method is tailored to process at least one liquid compound consisting of hydroxyethyl methacrylate monomers and methyl methacrylate monomers.

The method according to any one of claims 1-4, characterized in that the method is tailored to process at least one liquid compound consisting of long-chain methacrylate and acrylate comonomers.

The method according to claim 5, characterized in that the method is tailored to process at least one liquid compound consisting of 2-phenylethyl acrylate and 2-phenylethyl methacrylate monomers. 5

The method according to claim 1, 2 or 3, characterized in that the method is tailored to the processing of at least one liquid compound consisting of at least one siloxane monomer.

The method according to claim 8, characterized in that the method is tailored to the processing of at least one liquid compound consisting of dimethyl siloxane monomers.

10. The method according to claim 8, characterized in that the method is tailored to the processing of at least one liquid compound consisting of dimethyl diphenyl siloxane monomers.

11. The method according to any of claims 1-10, characterized in that the optical elements are prepared via polymerization of the first liquid compound in a mold.

12. The method according to any of claims 1-10, characterized in that the optical elements are prepared by machining, with at least one piece of machine tool, of solid semi-finished products prepared via polymerization of the first liquid compound.

The method according to any of the preceding claims, characterized in that the polymerization of at least one of any liquid compound is initiated by any form of irradiation or radiation. 30

The method according to claim 12, characterized in that the polymerization of the second liquid compound is initiated by irradiation with UV light.

An intraocular lens consisting of at least two optical elements consisting of at least two optical elements, the optical elements being obtained by polymerizing a first liquid compound, the first liquid compound consisting of a first monomer, and having at least one junction 5 between the optical elements on opposite connecting faces, characterized in that the connecting point is obtained by supplying a second liquid connection to at least one connecting face of one of the optical elements, wherein the second liquid connection consists of a second monomer, and with such positioning of said opposite connecting surfaces that these surfaces make contact with each other, and with polymerization of the second liquid connection.

The intraocular lens according to claim 15, characterized in that the lens is an accommodating intraocular lens.

The intraocular lens according to claim 15, characterized in that the lens is a multifocal lens.

18. The intraocular lens according to claim 15, characterized in that the lens is an adjustable multifocal lens.

The intraocular lens according to claim 15, characterized in that the lens is an accommodating multifocal lens.

An apparatus for assembling an intraocular lens, the lens consisting of at least two optical elements, the optical elements consisting of a combination of at least one polymer obtained by polymerization of a first liquid compound, and wherein the lens comprises at least one connecting point between the optical elements, wherein the connecting point consists of a combination of at least one polymer obtained by polymerizing a second liquid compound, characterized in that the apparatus consists of: - at least one fixing device for fixing at least one one of the optical elements, and - at least one feeding device for applying the second liquid connection to at least one connecting surface of at least one of the optical elements, and - at least one handling device for placing at least one optical element in at least one position in which at least one n of its connecting faces makes contact with said applied liquid connection on at least one connecting face of at least one of the other optical elements, and - at least one polymerization device for polymerizing said second liquid connection. 10

21. The apparatus of claim 20, characterized in that the fixation device consists of a standardized industrial fixation component for semi-processed lens parts, which fixation component is tailored for the component to provide fixation of the optical element on the apparatus for assembling and at least 15 one piece of machine tool.

22. The apparatus according to claim 20, characterized in that the feeding device is provided, inter alia, with a precision extruder, an extruder consisting of a combination of a cylinder, a plunger and a needle, which is tailored to accurately feeding the second liquid compound.

The device according to claim 20, characterized in that the polymerization device for polymerizing said second liquid compound comprises at least one device for polymerization via irradiation with UV light.