MXPA99002416A - Human applications of controlled stress - Google Patents
Human applications of controlled stressInfo
- Publication number
- MXPA99002416A MXPA99002416A MXPA/A/1999/002416A MX9902416A MXPA99002416A MX PA99002416 A MXPA99002416 A MX PA99002416A MX 9902416 A MX9902416 A MX 9902416A MX PA99002416 A MXPA99002416 A MX PA99002416A
- Authority
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- Mexico
- Prior art keywords
- pressure
- increase
- spine
- actuator
- abnormal condition
- Prior art date
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Abstract
An effect analogous to a tail-pinch effect is evoked in humans by apparatus for applying variable localized pressure to the spine. Control of the pressure can be accomplished manually, by remote control and/or automatically. By selectively applying pressure a number of changes can be evoked in the human including, for example, causing an increase in appetite, a change in sexual behavior, increased blood flow to brain, and/or an increase of neurotransmitters, including dopamine, serotonin and norepinephrine. The effect is useful in treating Parkinson's disease, depressive disorders, stroke and other conditions.
Description
HUMAN APPLICATIONS OF CONTROLLED VOLTAGE
BACKGROUND OF THE INVENTION Field of the Invention The invention relates to a pinching effect analogous to the human used in animals / and more particularly, with methods, apparatus, systems and techniques for modifying human behavior, for treating certain diseases and that affect other human conditions.
Technique, Previous Pinch effect is known from the prior art and its impact on animals is discussed in the literature. U.S. Patent No. 5,205,238 to Harry E.
Boyce, which was issued on April 27, 1993 entitled METHOD AND APPARATUS FOR INDUCING TENSE CONTROLLED BEHAVIOR IN ANIMALS, SUCH AS GREATER CONSUMPTION OF FOOD, LIQUIDS, MATING, MATERNAL OR SIMILAR BEHAVIOR. That patent describes methods and apparatus for applying controlled voltage to animals by mounting an apparatus on a part of the body of an animal and applying variable tension, such as a pinch. Devices of the type shown in that patent are sometimes known as "ABMMR" devices, which patent is hereby incorporated by reference in its entirety, however, the prior art does not address the application of pinching techniques. or a device of the ABM type to humans.
BRIEF DESCRIPTION OF THE INVENTION The present invention extends what has been done in the prior art to demonstrate an analogous pinching effect in humans. As discussed in greater detail hereinafter, the invention allows the treatment of Parkinson's disease, depressive disorders and stroke, in addition to a variety of other human conditions. The invention is directed to an apparatus for applying controlled tension by applying variable localized pressure to a human body, and includes a pressure actuator for applying pressure against a portion of a human body, and a length of flexible material holding the pressure actuator against the body. human body, even when pressure is applied. The invention is also directed to a system for applying a variable localized pressure to a human body, including a pressure actuator for applying pressure against a portion of a human body, and a remote control for sending one or more control signals to the actuator. of pressure on a communication link. The invention is also directed to a method for applying variable localized pressure to a human body, by placing a pressure actuator against a portion of the human spine; and selectively applying pressure to the spine using such an actuator. The invention is also directed to a method to produce an increase in appetite, a change in sexual behavior, increase blood flow to the brain, and / or an increase of neurotransmitters in the brain in the body of a human being, by placing a pressure actuator against a portion of the human spine; and selectively applying pressure to the spine using such an actuator. Neurotransmitters can be one or more of dopamine, serotonin and norepinephrine. This invention is also directed to the treatment of Parkinson's disease, depressive disorders and stroke, by placing a pressure actuator against a portion of the human spine; and selectively applying pressure to the spine using the actuator. The foregoing and other features, aspects and advantages of the present invention will become more apparent from the following detailed description of the present invention, when taken in conjunction with the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS The objects, characteristics and advantages of the system of the present invention will be evident from the following description, in which; Figure IA is an illustration of an exemplary mounting harness for securing a tension inducing device to a human body. Figure IB illustrates an exemplary remote control device for controlling the application of voltage or pressure to a human. Figure 2 illustrates the external appearance of an exemplary voltage inducing device shown in Figure 1. Figure 3 is a block diagram of the voltage-inducing device of Figure 2, and the exemplary control circuit. Figure 4 is a block diagram of an exemplary remote control device shown in Figure IB.
DETAILED DESCRIPTION OF THE INVENTION A pressure activator is contained in a belt, which the patient uses around the waist, with the stimulation mechanism such as a pressure head placed comfortably against the spinal cord. The stimulating pressures can be regulated personally by the patient. This method of providing therapy allows patients to personally control the "dose" that is being administered based on the current level of need Initial pilot studies using prototypes have resulted in a high level of acceptance and compliance of patients. Therefore, the therapy is not only effective against the disease, but the product will be accepted by the patient.Additional research on the uses of the devices based on the technology described here, indicates that these devices stimulate the release of certain chemical compounds in the brain, which are essential for the therapy and / or control of conditions such as Parkinson's disease, depression and stroke.This extension of the prior art technology provides effective therapies, without drugs, which will complete or be superior to the drugs currently available for some disease conditions and , in others, it provides therapy for which drugs are not yet available.
The device will be placed on a belt used around the waist, so that the stimulator is located along the spine. A personal control device will allow the patient to increase or decrease the level of stimulation. Consequently, instead of being "chained" to the cumulative effects of a drug at a given dose level, patients may increase or decrease the "dose" of the stimulation required at any given time. This feature adds enormous value. In 1973, Dr. Antelman and Henry Szechtman, Ph. D.
(Department of Bio-medical Sciences, University of
McMaster, Ontario, Canada), discovered that the application of moderate, non-painful pressure (pinching) to the tails of fully sated rats would induce the animals to eat. Pinch-induced feeding proved to be an extremely reliable and robust phenomenon, which Dr. Antelman and his colleagues were able to demonstrate in a significant percentage of over 4,000 tested animals. The initial report of the discovery of pinch-induced feeding appeared in Science. { Antelman and Szechtman, 1975), one of the leading scientific journals in the world. The repeated application of a pinch or pressure on the tail, several times a day, was subsequently shown by Neil, Rowland, Ph. D. (Department of Psychology, University of Florida, Gainsville, Florida) and Dr. Antelman, which induces Considerable obesity when applied for several days. This work, which was also applied in Science (Rowland and Antelman, 1976), showed that the application of a pinch or pressure on the tail six times a day for ten minutes each, over a period of four to five days, increased the caloric consumption of two and a half times to more than three times, and increased the weight by more than four times compared to control animals not exposed to stimulation by a pinch or pressure in the tail. The percentage of weight gain in the animals to which a pinch or pressure was applied to the tail, averaged 22% compared to 5% for the controls without pinching. This is equivalent to a gain of 99.9 kilograms (220 pounds) on a cow for meat of 454 kilograms (1,000 pounds) in less than a week. Interestingly, the pinch induced the largest percentage of weight gain (23.5% above and below the controls) in animals treated with estradiol benzoate, the main ingredient in several of the hormonal implants sold commercially in the markets of cattle for meat. In addition to its ability to increase weight gain in normal animals, the pinch is also able to reverse food deficits due to diseases or the anorexic effect of some drugs. In this way, it was demonstrated that pinching could induce feeding in rats or aphicic or adipic cats (that do not eat or drink) by cerebral lesions of the lateral hypothalamus. Such animals usually die unless they are fed by a tube. In fact, all but one of the unpinched controls died in this study with rats, while 42% of the animals that received the pinch or pressure in the tail survived (without being fed with a tube). These animals recovered from the point of view of recovering again the ability to eat spontaneously. Pinching also reversed the essentially complete akinesia in other circumstances, observed in those animals. This has also shown to reverse the damaging effects of brain injuries on reproductive behavior (Wang and Hull, 1980). Since the original report of feeding induced by a pinch or pressure in the tail by Antelman and Szechtman, have been published articles records on the subject and many highly committed scientists have been involved in this area of research. The types and species of animals in which feeding in response to a moderate stimulus has been demonstrated are now considerable. In fact, pinch-induced feeding has already been reported in such primitive species as molluscs (for example, it has been shown in marine slugs - Kavaliers and Hirts, 1980). The body of knowledge constantly expanding throughout the world around the improvement of eating behavior induced by a pinch, quickly seems to have important applications in industries related to the production of animals for food, where they are constantly being sought by producers methods more efficient to increase feed intake and weight gain. The immediate recognition of those potentially lucrative applications of the pinch principle for milk and meat production led scientists to investigate those opportunities through the development and testing of their first devices, called Animal Behavior Modifiers, or *? BWm. The original work of Antelman and his colleagues showed that the neurochemical compound, dopamine, played an important role in the induction of feeding and other behaviors induced by the application of a pinch or pressure on the tail. It is now known that dopamine - which is depleted in Parkinson's disease - is essential for the initiation of motivated behavior in animals, such as eating, sexual and maternal behavior, among others. Subsequent investigations by others have confirmed and expanded the value of the pinch stimulus as a technique without drugs to alter brain neurochemistry in animals. For example, it has now been proven and repeated that a pinch reliably releases the neurotransmitters dopamine, serotonin and norepinephrine from brain cells. It also produces a marked increase in blood flow to the brain. In this way, what began as a way to get animals to eat when ordered, became a major contribution to the study of brain neurochemistry. All this was possible because the pinch or pressure in the tail is very reliable to activate the connections of brain behavior. At the end of the 70s, only a few laboratories in this country were using the pinch or pressure in the tail. In the mid-90s all laboratories in the world were using the pinch or pressure technique in the tail to study the actions of neurochemical compounds. The application of their discoveries according to the invention for the treatment without drugs of a host of conditions with a human version of the ABM, is discussed later. The logic of the treatment of human diseases through the application of this science, is based on the discovery that the activation of behavior via the application of a pinch or pressure on the tail in animals, produces effects that can mimic conventional treatments for certain brain diseases. The advantages of a device for use in humans, which will be referred to as a HBM (Motivator of Human Behavior), in relation to drug therapy are substantial. First and foremost, the concept of Patient Directed Therapy is introduced, available on demand, in any * dose "required, based on * ecesidades". How a person feels at any given time may vary as a function of changes in either or both of the physiological and / or external environments. For example, even healthy people have good days and bad days, as well as good and bad periods within the same day. Therefore, every time a drug is taken, for any disease, there is always the potential difficulty of taking too much in relation to a current state of the individual and therefore causing undesirable 'side effects', or taking a low dose, and of In this way, failure to alleviate the symptoms of that disease, when such problems occur, it does not matter what a patient can do, except wait until the next scheduled administration of the drug and wait for the problem to be relieved then, in other words, once A drug is in a person's system, the person is at the mercy of the consequences, good or bad, and can do little or nothing until they resolve on their own.
In contrast, the great advantage of a device such as the HBM, is that its effects can be modified immediately. If the pressure, that is, the '' dose * '*' is too high, it can be lowered quickly, or if it is too low it can rise.When the symptoms worsen or improve, the * dose "can be changed immediately. In summary, the patient is not captive to a predetermined program of drug administration, but he or she can now control the schedule based on their "needs". In this way, the danger of any unaddressed effects is greatly diminished, since therapy is kept to a minimum and is taken only as required. The portability and capacity of a remote control are also important advantages of HBM in relation to drug therapies. As long as the device is used, it is always immediately available for use. For example, one does not need to look for water to take pills. Similarly, other people do not need to know when a therapy is being given to a patient. In the case of severely disabled patients, unable to activate a typical remote control device, a voice activation device is provided. There are approximately 1.5 million patients with Parkinson's Disease in the United States, Japan and Europe and 2.5 million patients worldwide. The disease is caused by the destruction of a specific nucleus in the brain, which contains large amounts of the neurotransmitter dopamine. The main treatment is the drug levodopa used in combination with an inhibitor of related enzymes, which increases the levels of dopamine available in the brain, thus partially reversing the effects of the disease. There are drugs that usually do not occur until the symptoms become serious, because levodopa will eventually cease to be effective after several years of treatment. Anticholinergic drugs, which block acetylcholine receptors in the brain, usually occur first in the course of treatment and levodopa will usually be introduced when anticholinergics are no longer effective. New drugs, which act similarly to dopamine and new types of enzymatic blockers, which protect dopamine from destruction, are under study for the treatment of the disease. However, the role of activation in providing relief from the symptoms of the akinetic effects of Parkinsonism is well established. Actually, this has been recently portrayed in the film "wakening" (Awakening), based on the book of the same name by neurologist Oliver Sachs.
In animals it has been demonstrated and accepted by scientists throughout the world, that the activation of behavior by the application of a pinch or pressure on the tail increases the levels of extracellular dopamine in the nigrostriatal system of the brain. The invention makes possible the treatment of Parkinson's disease in humans. It is thought that there are 20 million depressed people in the United States. As much as 7% of the population may be depressed at some point in their lives and 3% will be severely depressed. In 1994, almost 9 million people sought treatment for depression and 5.5 million people were treated with drugs that year. The most common form of treatment for depression is the use of drugs, which block the reabsorption of serotonin in the brain, of which the most commonly prescribed class of drugs is Prozac. More than 15 million prescriptions are made each year for depressive disorders, but only 10% of patients go to psychiatrists. The rest is treated by general practitioners. The most effective drugs in the treatment of depression freely increase the levels of the neurotransmitters norepinephrine and serotonin in the brain, blocking its reabsorption in brain neurons (Freeman et al, 1993). The most effective of all antidepressant treatments is not a drug, but an electroconvulsive shock, which is a stressful stimulus. This and other antidepressants that are not drugs such as sleep deprivation, suggest a role of behavioral stimulus in the treatment of depression. It is known that the activation of behavior through the application of a pinch or pressure in the tail in laboratory animals, induces an increase in low extracellular levels of serotonin, dopamine and norepinephrine in the brain. It is known that these neurotransmitters are involved in depression in humans. The commonly used antidepressant drugs actually increase the levels of those neurotransmitters in the brain, blocking the reabsorption of those neurotransmitters in the presynaptic cells. Therefore, the invention allows to activate the behavior in humans, which increases the levels of neurotransmitters in the brain and allows an adjunctive treatment or treatment of depression. The savings in drug costs, not to mention avoiding the side effects of drugs, represent a very significant addition to the possibilities of treating depression. The use of such an activator would be useful as a treatment used in conjunction with conventional drugs, but would also allow the drugs to be used at lower doses where side effects would be less problematic.
There are 500,000 stroke victims each year in the United States. At least 300,000 patients each year will begin rehabilitation treatment after an attack. New types of drugs are being developed. Among those drugs in development, there are compounds known to increase cerebral blood flow and extracellular glucose levels in the striatum. Several research articles that relate changes in blood flow in glucose levels with pinching or tail pressure in animals are found in the literature. The use of the invention to create such a stimulus in humans contributes to the rehabilitation of brain function after stroke damage or could be used to treat ischemic insufficiency. The device for human use, currently referred to as the "Human Behavior Modifier", or "HBM", is based on the same principles used in the Animal Behavior Modifier (ABM) .The HBM is a device that applies pressure and a method Used to produce particular behaviors, it includes a mechanism to mount the device along the spine, a mechanism to apply variable localized pressures to the area of the spine, and a device to automatically control variations in applied pressures. includes the steps of assembling the apparatus to apply pressure and allow the use of variable pressure with time in a predetermined way.The way to automatically control the variations in pressures, is obtained using a programmable electronic timer circuit.Included in the timer circuit a program is provided to produce pressure randomly with the The HBM includes a belt and a halter, which holds the device to apply pressure when the device is mounted along the spine. Another method for mounting the apparatus for applying pressure is an adhesive patch system, which holds the device in place. A manual control system is included, which allows various pressures to be applied automatically over time in a predetermined manner. The manual control includes an interruption capability, which cancels any previous programming. In a study conducted by one or more of the co-inventors, a number of subjects were tested using lists of words of equal difficulty from the evaluation methodology of the ADAS (Altzheimer's Disease Assessment Scale). Subjects were given a list of words and given some time to study the list. The list was then placed face down and they were asked to repeat as many words from the list as possible.
This portion of the test was repeated in different ways and in each case, the participants achieved answers of 95% to 100% correct. The participants were then presented with a second list of words of equal difficulty accompanied by a more distracting stimulus, such as white noise. The subjects to whom a more distracting stimulus was presented had a significant increase in the number of errors when repeating the ADAS list. The percent of correct answers decreased from the 95% to 100% range to the 30% to 50% range. Using a different list of equal difficulty, the same subjects were then presented with the same more distracting stimulus in the presence of controlled tension as described below. The percent of correct answers was again increased to the range of 90% to 95% in the presence of controlled tension. In this way, it is inferred that, since the only variable that changed was the presence of controlled tension in humans, the controlled tension resulted in an increase in selective attention capacities, or in the ability to put aside the stimuli distractors. Figure 1A illustrates a belt with stays to secure a tension inducing device 100 to a human body. Figure IB illustrates a remote control device for interacting with unit 100 to control the application of pressure, a form of tension. The straps 110 shown in Figure 1A sit on the shoulders as suspenders and the belt 120 is wound around the human body to place the tension-inducing unit 100 on the spine. Preferably, the straps are adjustable to allow placement of the tension-inducing unit 100 on the different portions of the spine, to achieve different effects on the human body. Figure 2 illustrates the voltage inductive unit
100 in more detail. The voltage-inducing unit 100 is approximately 1.81 cm (1 1/2") high by 3.81 cm (1 1/2") deep by 7.62 cm (3") in length, with belt buckles 200 for connecting to the belt shown in Figure IB A pressure head 210 is activated by a servo unit within the box to apply controlled pressure to the area of a human's spine A pressure sensor 220 is optionally installed and preferable to the Same level as the pressure head 210 for detecting the pressure that is being applied against the spine for controlled purposes Control buttons 230A and 230B are provided to allow the human subject to control the amount of pressure in a self-administration mode.
Figure 3 is a block diagram of the voltage-inducing device shown in Figures IA and 2. As shown in Figure 3, antenna 300 is used to both receive and transmit. A double coupler or duplex coupler 305 maintains the isolation between the transmit and receive paths. The incoming commands of the remote control device 150 shown in Figure IB are transmitted through the coupler 305 to the receiver 310 and then to the decoder 320, where the different commands are decoded. The two most significant orders involve an increase in the pressure shown on the line 331 and a decrease in the pressure shown on the line 332. These lines connect the servomotor 330 and activate the servomotor 330 to increase or decrease the pressure applied to the spine dorsal of the human, respectively. Servomotor 330 activates a threaded shaft on which the pressure head 340 is mounted. In operation, the servomotor causes the pressure head to move back and forth in a controlled manner, beyond the front of the actuator. box or container shown in Figure 2, to increase or decrease the amount of pressure against the spine. Servomotor 330 can drive the threaded shaft directly or through an intermediate chain of change, depending on obvious design considerations.
A pressure sensor 350 is mounted at the same level as the surface of the pressure head and is used to measure the amount of pressure that is being applied against the human. The amount of pressure is encoded in an encoder 360 and sent to the transmitter 370 to be transmitted back to the remote control device 150, shown in FIG. IB. That device will be discussed later. In Figure 3 there is shown a manual user control 380 connected to the decoder to allow the user to control the amount of pressure manually, in response to the buttons 230A and 230B shown in Figure 2. Figure 4 is a block diagram of the device of remote control 150 shown in Figure IB. A pressure control device 400 is used, such as a lever or a pair of increase / decrease switches to increase or decrease the pressure. The control signals generated by the pressure control 400 are applied to the CPU 410, which controls the generation of commands by the order generator 420, which are sent via the emitter 430, duplex or coupler duplex 440 and the antenna 445 are attached to the device shown in Figure 3. When the pressure is increased or decreased, the pressure is detected by the pressure sensor 350, shown in Figure 3 and the value of the detected pressure is returned by an encoder 360 and the transmitter 370 to * the antenna 300, all shown in Figure 3. The returned return information is received at the antenna 445 shown in Figure 4 and coupled over the coupler 440 to the receiver 450 and the decoder 460 decodes the value of the pressure and applies it to the CPU 410, which uses the detected pressure for control purposes. Using the devices shown in these figures, one can place and apply tension to a human in a reliable way, to achieve the desired effects. The techniques described above can be used to facilitate the treatment of Parkinson's disease, depressive disorders and stroke. In addition, the application of controlled tension increases coronary blood flow, increases hemoglobin levels (as a treatment of iron deficiency anemia or general anemia), reduces the symptoms of sickle cell anemia, provides a treatment for human sexual dysfunction, provides a possibility to treat fertility without the results of multiple births that often accompany other forms of treatment, it is useful to control and / or prevent feeding disorders such as those that occur in patients with cancer, anorexia nervosa or bulimia. The use of controlled tension results in better surveillance and improved selective attention and can be usefully applied in the hyperactive condition of attention deficit for children and adults, and in certain diseases such as schizophrenia. Although the present invention has been described and illustrated in detail, it should be clearly understood that it was done by way of illustration and example only, and that it should not be taken as a limitation thereof, the spirit and scope of the present invention will be limited only by the terms of the appended claims and their equivalents.
Claims (43)
- CHAPTER CLAIMEDICATORÍO Having described the invention, it is considered as a novelty and, therefore, the content is claimed in the following CLAIMS: 1. An apparatus for applying variable localized pressure to a human body, characterized in that it comprises: a. a pressure pusher to respond to a control signal to apply pressure against a portion of a human body, and b. at least one length of flexible material for holding the pressure actuator against the human body when pressure is applied.
- 2 . The apparatus according to claim 1, characterized in that the flexible material is an adhesive patch.
- 3. The apparatus according to claim 1, characterized in that the flexible material is a belt. The apparatus according to claim 1, characterized in that the actuator comprises a pressure head and a pressure sensor. 5. The apparatus according to claim 2, characterized in that the actuator increases the applied pressure until the pressure sensor indicates that the pressure exceeds a threshold. • 6, The apparatus according to claim 1, characterized in that at least one belt is part of a harness to hold the pressure actuator in place. The apparatus according to claim 1, characterized in that it also comprises a remote control for generating the control signal. The apparatus according to claim 7, characterized in that the remote control comprises a central processing unit. 9. The apparatus according to claim 8, characterized in that the remote control comprises. a transmitter and a receiver. 10. The apparatus according to claim 1, characterized in that it also comprises a control accessible to the user to generate the control signal. The apparatus according to claim 1, characterized in that it also comprises a timer to generate a control signal to apply pressure and selectively remove pressure. 12. The apparatus according to claim 7, characterized in that the timer is programmable. The apparatus according to claim 7, characterized in that the timer programs the application of pressure to occur at random or pseudo-random intervals. The apparatus according to claim 1, characterized in that it also comprises a control accessible to the user to adjust the amount of applied pressure. 15. The apparatus according to claim 1, characterized in that the control signal is activated by the voice. 16. The apparatus according to claim 1, characterized in that it also comprises a manual switch. 17. A system for applying variable localized pressure to a human body, characterized in that it comprises: a. a pressure actuator for responding to a control signal for applying pressure against a portion of a human body, and b. a remote control for sending one or more control signals to the pressure actuator over a communications link. 18. A method for applying variable localized pressure to a human body, characterized in that it comprises the steps of: a. placing a pressure actuator against a portion of the human spine; and b. selectively apply pressure on the spine using the actuator. The method according to claim 18, characterized in that the step of applying pressure selectively comprises applying pressure to the spine periodically. The method according to claim 18, characterized in that the step of selectively applying pressure comprises applying pressure to the spine at irregular intervals. 21. The method according to claim 20, characterized in that the amount of pressure applied to the spine can vary with each case of application of pressure. 22. The method according to claim 18, characterized in that a user can control the amount of applied pressure. 23. The method according to claim 18, characterized in that a user can initiate the application of pressure. 24. The method according to claim 18, characterized in that a user can control an average duration between the pressure applications. 25. A method for producing a change in the body of a human being, characterized in that it comprises the steps of: a. placing a pressure actuator against a portion of the human spine; and b. selectively apply pressure on the spine using the actuator. 26. The method according to claim 25, characterized in that the change is an increase in appetite. 27. The method according to claim 25, characterized in that the change is an increase in sexual activity. 28. The method according to claim 25, characterized in that the change is an increase in blood flow to the brain. 29. The method of compliance with the claim 25, characterized in that the change is an increase of neurotransmitters in the brain. 30. The method according to claim 29, characterized in that increase in neurotransmitters is an increase in dopamine. 31. The method according to claim 29, characterized in that the increase in neurotransmitters is an increase in serotonin. 32- The method according to claim 29, characterized in that the increase in neurotransmitters is an increase in norepinephrine. 33. A method for treating an abnormal condition in humans, characterized in that it comprises the steps of: a. placing a pressure actuator against a portion of the human spine; and b, selectively applying pressure to the spine using the actuator, 34. The method according to claim 33, characterized in that the abnormal condition is Parkinson's disease. 35. The method according to claim 33, characterized in that the abnormal condition is a depressive condition. 36. The method according to claim 33, characterized in that the abnormal condition is apoplexy. 37. The method according to claim 33, characterized in that the abnormal condition is iron deficiency anemia. 38. The method according to claim 33, characterized in that the abnormal condition is general anemia. 39. The method according to claim 33, characterized in that the abnormal condition is sickle-cell anemia. 40. The method according to claim 33, characterized in that the abnormal condition is infertility. 41. The method according to the claim 33, characterized in that the abnormal condition is a condition of the food type. 42. The method according to claim 33, characterized in that the abnormal condition is the hyperactive condition of lack of attention. 43. The method according to claim 33, characterized in that the abnormal condition is schizophrenia.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US026007 | 1996-09-12 |
Publications (1)
Publication Number | Publication Date |
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MXPA99002416A true MXPA99002416A (en) | 2000-05-01 |
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