MXPA06010715A - Anticuerpo del receptor del factor de crecimiento humano anti-epidermico. - Google Patents

Anticuerpo del receptor del factor de crecimiento humano anti-epidermico.

Info

Publication number
MXPA06010715A
MXPA06010715A MXPA06010715A MXPA06010715A MXPA06010715A MX PA06010715 A MXPA06010715 A MX PA06010715A MX PA06010715 A MXPA06010715 A MX PA06010715A MX PA06010715 A MXPA06010715 A MX PA06010715A MX PA06010715 A MXPA06010715 A MX PA06010715A
Authority
MX
Mexico
Prior art keywords
antibodies
egfr
growth factor
factor receptor
epidermal growth
Prior art date
Application number
MXPA06010715A
Other languages
English (en)
Inventor
Meilin Liu
Zhenping Zhu
Original Assignee
Imclone Systems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imclone Systems Inc filed Critical Imclone Systems Inc
Publication of MXPA06010715A publication Critical patent/MXPA06010715A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La Presente invencion provee un anticuerpo completamente humano que se enlaza al EGFR humano con una afinidad comparable o superior a IMC-C225, y que neutraliza la activacion de EGFR. Los anticuerpos de cadena simple, anticuerpos de cadena simple multivalentes, anticuerpos de dominios dobles, triples y sencillos. La invencion ademas provee acidos nucleicos y celulas anfitrionas y animales que codifican y expresan esos anticuerpos. La invencion ademas proporciona un metodo para neutralizar la activacion de EGFR, el tratamiento en un mamifero con crecimiento neoplasico y enfermedades hiperproliferativas no cancerosas usando los anticuerpos solos o en combinacion con otros agentes.
MXPA06010715A 2004-03-19 2005-03-21 Anticuerpo del receptor del factor de crecimiento humano anti-epidermico. MXPA06010715A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US55455504P 2004-03-19 2004-03-19
US62426404P 2004-11-02 2004-11-02
PCT/US2005/009583 WO2005090407A1 (en) 2004-03-19 2005-03-21 Human anti-epidermal growth factor receptor antibody

Publications (1)

Publication Number Publication Date
MXPA06010715A true MXPA06010715A (es) 2007-05-23

Family

ID=34964896

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA06010715A MXPA06010715A (es) 2004-03-19 2005-03-21 Anticuerpo del receptor del factor de crecimiento humano anti-epidermico.

Country Status (18)

Country Link
US (1) US7598350B2 (es)
EP (2) EP1735348B1 (es)
JP (1) JP4734319B2 (es)
CN (1) CN103007279B (es)
AU (1) AU2005224267B2 (es)
CA (1) CA2560305C (es)
CY (2) CY1113037T1 (es)
DK (1) DK1735348T3 (es)
ES (1) ES2387809T3 (es)
HU (1) HUS000495I2 (es)
LT (1) LTC1735348I2 (es)
LU (1) LU93093I2 (es)
MX (1) MXPA06010715A (es)
NL (1) NL300819I2 (es)
PL (1) PL1735348T3 (es)
PT (1) PT1735348E (es)
RU (1) RU2402569C2 (es)
WO (1) WO2005090407A1 (es)

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LU93093I2 (fr) 2016-08-01
WO2005090407A1 (en) 2005-09-29
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US20070264253A1 (en) 2007-11-15
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