MXPA05008386A - Electrolysed superoxidated solution with a neutral ph. - Google Patents

Abstract

The electrolysed superoxidated solution and gel (E.S.S) has been improved so as to remain a longer period of time in contact with skin tissues during its semisolid phase, thereby reducing the healing time in burnt patients. The invention is also useful in maxillofacial surgery where the tissue regenerating time is short and the healing fast, the inventive solution acting as an antiseptic and germicide for medical instruments, having a 2-year expiration date at room temperature without losing its properties, controlling viral and skin infections, including lesions caused by the varicella virus and ulcers in the neck of the uterus caused by the papillomavirus. The gel is useful as a lubricant for preservatives, and can be vaginally applied since it does not cause irritations, also decreasing HIV virus transmission. The present invention is obtained by a saturated electrolysis process including reactive-grade chlorine and water, whereby an ion solution from chlorine is obtained, such as sodium hypochlorite, chlorine dioxide, hypochlorite ion, molecular chlorine, sodium chlorine, as well as oxygen-derived ions, such as O3 molecular oxygen, hydroxyl radicals, hydrides. The solution has a pH of from about 6.4 to about 7.5, and a reduction-oxide potential of from about 750 mv to about 950 mv.

Description

(A SUPPLEXIZED SOLUTION-DACONPHNEUTRO. (S.E.S.) CAMPODELAINVENTION This invention both in its liquid phase, as well as in its gel, has achieved changes that have allowed in its semi-solid phase, to remain longer in contact with the skin tissues favoring a germ-free environment and a faster dissolution by shortening in burned patients the healing time, in relation to other conventional patients, in addition another way of demonstrating it, has been in the use of facial masilo surgery, where the time of tissue regeneration and bone callus formation is shortened in time and the healing is faster.

Therefore, the super-oxidized electrolyzed solution with neutral ph, as in its semisolid form, have achieved changes by shortening the healing time of the wounds, as well as in the treatment of deep infections with circulatory alterations, as in the case of gangrene and in Its gel state has favored the formation of granulation tissues and healing is faster.

It also serves to disinfect medical material, and eliminates pathogenic microorganisms from medical instruments, in addition its antiseptic effect does not damage the tissues on which it is applied, since it has been used in infected superficial wounds, as well as in the washing of deep infections and it has been achieved sterility, since the electrolyzed solution super oxidized ph neutral its expiration can be from 18 months to two years at room temperature, without losing its properties, without risks, or special requirements.

It has high-level sterilizing and disinfecting properties, which allow it to be used to control viral, coetaneous, mucosal infections including varicella-zoster virus lesions and ulcers in the cervix, produced by the human papillomavirus in its gel state. , it is like preservative lubricant, to diminish the possibilities of viral contagion during sexual activity, it can also be applied directly by vaginal route, which decreases the transmission of human immunodeficiency virus (AIDS), it has bacterial spore destroyer effect, also It has sterilizing properties, as a disinfectant, which does not cause corrosion, dermal irritation, ocular irritability, oral toxicity, nasal mucosal toxicity.

Due to its properties when applied to meats in traces, it allows a longer shelf life, in the application in the agricultural field, especially in postharvest when it is packed, eradicates any microorganism.

There is currently an acid solution in wound healing, and we could say that it is slow and does not produce the rapid healing that my invention has, besides that it can be applied without damaging or irritating the skin, in deep cavities and has the indicated uses to avoid sexual contagion.

For what was thought in the development of the present product that is intended to protect, by means of the present application, since said invention has been proven in the management of both superficial and deep infections and also in the application of meats in traces its application It allows a life of the meat in the shelf without more elongated microbes and in the agricultural field an excellent quality is obtained in the fruit.

DESCRIPTION OF THE INVENTION The characteristic details of this innovative super oxidized solution with ph. neutral, (SES) obtained from an electrolysis process, in which a solution of chlorine-derived ions, such as sodium hypochlorite (HCLO), is obtained from a saturated solution of sodium chloride reactive grade and pure water ), chlorine dioxide (Clo2), lon hypochlorite (Cio), molecular chlorine (CI2), sodium chloride (NaCl). In addition to oxygen-derived ions, such as, ozone (O3), oxygen peroxide (H2O2), molecular oxygen (O3), hydroxyl radicals (OH), hydrides (H +).

The super-oxidized electrolyte solution has a range of pp. from about 6.4 to 7.5, a potential oxide-reduction between 750 to 950 mv and a free chlorine content of 10 ppm to 120 ppm. The pp. of the solution comprising stabilized electrolyzed chlorine is reduced to about 6.8 to 7.5, giving the solution bactericidal, virucidal, fungicidal and sporicidal properties.

This is attributed to the oxidation effect of the sulfhydric (-sh) groups and amino acids of the bacterial wall, which also affects the respiration and nutrition process of the microorganisms, producing oxidation of the respiratory components, inhibition of the synthesis of proteins, alteration in cellular metabolism with decreased production of high-energy phosphates (adenosine phosphate), independently of the breakdown of DNA strands and repression of RNA.

Due to the controlled concentration and the chemical stability of the ions, achieved in this process, the solution is not toxic to the cells of higher species by skin or mucosal contact, does not damage the conjunctiva or the mesothelial membranes (pleura or peritoneum) .

The super-oxidized solution with neutral pH (SES), has been proven as an antiseptic in the management of superficial and deep wound infections and in large cavities due to its germicidal properties eliminating the presence of bacteria, viruses from the tissue surface , fungi and spores promoting healing.

It can also be used by immersion allowing the disinfection of non-critical medical instruments in just 1 minute and the sterilization of critical material in 15 minutes.

It is important to mention that the application by aspersion in meats in traces highly decreases the microbiological load, allowing a longer half shelf life.

It is important to highlight the importance of the application of the super-oxidized electrolyte solution (S. E .S.) And in its semi-solid phase in the agricultural field especially in post-harvest and packaging, since any microorganism is eradicated and with this a fruit is obtained with excellent quality and a longer half shelf life.

It is worth noting the disinfecting effect of the super-oxidized electrolyte solution (S. E .S.) In the treatment of water, deep wells, drinking wells, waste and industrial wells.

Currently, complete stability of the super-oxidized electrolyte solution (SES) has been achieved, which gives it a useful half-life of 18 months to 2 years, stored at room temperature and protected from sunlight without losing its properties, which allows it to production, distribution and storage without risks or special requirements.

It is important to point out that the changes achieved in order to use the different physical states of the super-oxidized electrolyzed solution (S. E .S.), Have allowed that in the semi-solid phase (GELIFIED) to remain longer in contact with the tissues favoring an environment germ-free, and rapid tissue regeneration, when using the super-oxidized electrolyte solution (S. E .S.) in GEL, in burned patients, shortening the healing time.

The efficacy in burned patients is that they shorten the healing time in relation to patients with conventional treatments, since laxas scars are formed, of better biological quality.

It was demonstrated in the use in facial masilo surgery where the time of tissue regeneration and bone callus formation has been shortened, even more, when using the super-oxidized electrolyte solution (S. E .S.) In the form of GEL, In patients with cutaneous ulcers resulting from postphlebitic syndrome or chronic arterial insufficiency, they have favored the formation of granulation tissue and faster healing.

From the test observations of the super-oxidized electrolyte solution as its semisolid form (GEL) its tolerance was tested in live animals, in search of dermal irritation, ocular irritability, oral toxicity, nasal mucosal toxicity, administration in bronchial washes, being completely harmless .

Later for its analysis, the super-oxidized electrolyte solution (S. E .S.) As its semisolid gel form, were subjected to a controlled clinical trial (RCT's) in animal models., exposing the endothelial surfaces of the pleura and the peritoneum, being less inflamogenic than the 0.9% saline solution, then carried out phase II studies (healthy volunteers) in which the innocuousness in the topical application is demonstrated and finally it was used in studies of phase III in which it was applied both in the treatment of infected superficial wounds, as in the washing of bone wounds and in the treatment of deep infections such as peritonitis, empyema and even in infections with circulatory alterations as in the case of gangrene.

It has also been proven in the treatment of infections secondary to diabetes mellitus, such as infections secondary to gangrene of fournier showing that its content of ions "free radicals" when reacting with the pro-inflammatory and defensive factors of human cells conditions a destructive effect of the proteins of the bacterial wall, altering its metabolism and allowing the diffusion of the ions that damage the replication of the DNA so they can not generate resistance to this process.

METHOD OF PRODUCTION OF THE SUPEROXED ELECTROLYZED SOLUTION WITH NEUTRAL pH: REQUIREMENTS: a) .- Demineralized water.- This water must have the following physical-chemical and microbiological characteristics: - pH between 6.0 and 7.0 - hardness as CaCO3 less than 1 grain per gallon. - Conductivity less than 8 uS. - Dissolved total solids less than 5 ppm. - Chlorine equal to zero. - The bacteriological study must have 0 ufe of viable mesophilic bacteria. For coniferous bacteria it must be less than 3 by the most probable number method. Must be absent from E. coli and free of P. aeruginosa per 100 ml of sample. b) .- NaCl.- Sodium chloride must be a reactive grade with a minimum purity of 99.9%. c) .- Electric power.- The electrical energy that feeds the "SES" machine is three-phase.

DESCRIPTION OF SPECIFICATIONS. (FIGURE I) 1. - The entrance of the demineralized water to the "SES machine", must be through a mixture of demineralized water and a NaCl solution with a known concentration for example: 5%, 10%, 20%, 30%, etc.) , this mixture will depend on the concentration of ions that are required in the final product. For example: water inlet 20 l / min, 10% NaCl (tank), NaCl / water 0.05% w. this is equal to a concentration of approximately 80 ppm free chlorine. 0.1% w NaCl / water = 120 ppm free chlorine. 2. - The demineralized water is carried by means of a 1.5 kg / cm2 pump to a mixer as well as the sodium chloride solution through a pump of 0J It / min. 3. - The previous mixture is carried to the two cells, each passing through a flow sensor that is regulated by a sphere valve (the flow sensor is connected to a digital reader). 4. - The machine S.E.S. It consists of two cells. 5. - The NaCl solution is ionized and separated inside the cell, this cell is composed, on 2 sides of PVC, by 2 metal plates (platinum / titanium) with positive charge (anode) and 2 metal plates (platinum / titanium) ) with negative charge (cathode). See the description below attached copy). 6. - Two types of solution are obtained from each cell, one that is acid from pH 2.0 to 3.0 and another alkaline solution from pH 12 to 13. In this way, the two alkaline solutions are united and deposited in a container (alkaline) and the two acid solutions are deposited in a container (acid). 7. - The acid product is used 100%, while the alkaline product is used to 20 to 30% and the rest is discarded. 8. - Once the acid and alkali tanks reach a medium level, these solutions are mixed in a ratio of: acid solution within a range of 1 to 30 Its / min (50 to 90%) and an alkaline solution within a range of 1 to 20 Its / min (10 to 40%) these flow through two tubes that are connected between each other this mixture reaches a mixing tank through a 90 ° elbow directed downwards and opposite to the side where they are the electrodes to avoid bubbling and do not alter the pH and ORP readings. NOTE: the mixing tank consists of two electrodes that read the pH and ORP respectively. 9. - From the mixing tank, the super-oxidized electrolyzed solution with neutral pH is pumped to a finished product receiving tank.

METHOD OF PRODUCTION TO PRODUCE THIS SUPEROXIZED ELECTROLYZED SOLUTION WITH NEUTRAL PH COMPOSED BY IONS, THE FOLLOWING REACTIONS ARE CARRIED OUT. a) 2H O + 2e (gas) + 20H e) NaCl + H20 NaOH + Cl-b) 2H O + 2e H (gas) + 2HO f) NaCl + H2O NaOH + ClO-c) 2CI-2e Cl (gas) g ) 2 NaCI + H20 2 HCIO + 2Na + d) Cl + HO HCIO and HCl h) 2NaCI + 2H2 O H2 O2 + 2NaCI + H2 i) 6 NaCl + 3 H20 03+ 6 HCl + 6 Na + FORMULAS OF THE SUPEROXIZED ELECTROLYZED SOLUTION WITH NEUTRAL pH AS A FINISHED PRODUCT: 1. - EVERY 100 mL contains: ACTIVE CHLORINE 10 - 12 mg Available in ion form: Permissible range according to FDA and EPA mg / 100 Ml HCIO 4.5 mg CIO2 0.15 - 0.8 CIO 3.5 mg HCIO 2.5 - 4.5 H2O2 0.5 mg CIO 1.5 - 3.5 NaCl 4.0 mg H2O2 0.4 - 0.6 03 0.02 - 0.5 * VEHICLE CBP 100 mL NaCl 2 - 15 * PURIFIED WATER * Neutral pH THE PH RANGE IS FROM 6.4 TO 7.5 THE ORP IS: 750 to 950 mV 2.- Each 100 ml contains: Active chlorine 10 - 12 mg. Available in the form of ions: HCIO 4.0 mg / 100ml CIO 3.Omg / 100ml CI02 0.7 mg / 1 OOml NaCl 4.3 mg / 1 OOml 3. - Each 100 ml contains: Active chlorine 7.5 - 9.5 mg / 100ml Available in the following ions: HCI0 3.0 mg / 1 OOml CIO 2.0 g / 100ml CI02 .... 0.5 mg / 1 OOml NaCl .... 3.5 mg / 100ml H202 .... 0.5 mg / 1 OOml 03 0.05 mg / 1 OOml 02 (as gas ) 4. - Each 100 ml contains: Active chlorine 8.5 - 9.5 mg / 100ml Available in the following ions: HCIO 3.5 mg / 1 OOml CIO 3.0 mg / 1 OOml NaCl 2.4 mg / 1 OOml CI02 0.6 mg 03 0.05mg / 100ml 5. - Each 100ml contains: Active chlorine 10 -12 mg / 100ml Available in the following ions: HCl0 4.5 mg / 1 OOml CIO 3.5 mg / 100ml NaCl 3.3 mg / 1 OO l H202 0.5 mg / 1 OOml

Claims (22)

REINVIDICATION Having sufficiently described my invention, I consider as a novelty and therefore claim as my exclusive property, what is contained in the following clauses

1. - In the treatment of both partial and total thickness burns, in the understanding that during the initial handling the solution serves as an antiseptic product for the initial washing and decontamination, followed by the application of the super-oxidized electrolyte solution (S. E .S. .) WITH PH NEUTRO IN GEL, in addition to acting with all its germicidal properties, acts as a moisturizing cover, which decreases the loss of liquids through the burned surface, this protective barrier moisturizing, also accelerates the healing process . The super-oxidized electrolyte solution (S. E .S.) WITH NEUTRAL GEL PH, used in the treatment of both partial and total thickness burns, which during initial handling the solution serves as an antiseptic product for initial washing and decontamination, followed by the application of the gel solution, which in addition to acting with all its germicidal properties acts as a moisturizing cover with which the loss of liquids through the burned surface is diminished, this protective and hydrating barrier also accelerates the process of healing according to theories.

2. - The antiseptic effect combined with the tissue regenerative effect and the high oxygen concentrations allowed the super-oxidized electrolyzed gel solution with neutral pH gel to serve as an interface to partial thickness grafts, helping the initial tissue inhibition, improving the cups of integration of the grafts.

3. - When applying the GEL on surfaces on the other hand bloody reduces the bleeding in an important way so I claim its use as a coagulant and haemostatic agent, with the understanding that the reactive parts when coming into contact with the platelets activate and through them to the coagulation shell depending on fibrin, on the other hand, also interferes with the release of nitric oxide favoring a transient basal spasm that allows the segregation of fibrin and platelets.

4. - When applying super oxidized electrolyzed solution with neutral ph in gel, on bone cuts made in masilocal treatments we have certified the acceleration in the ossification process calcification of said lesions, arriving to the conclusion that due to the components of the GEL, the acceleration of osteogenesis, an effect that is also the subject of claims.

5. - The antiseptic effect of internal use due to the fact that in controlled clinical trials (RCT.S) In animal models SES with neutral pH was tested as antiseptic for internal use, exposing the endothelial surfaces, the pleura and the peritoneum without this condition no type of reaction different to that produced by normal saline until today in the gold standard for body cavity washings, and against the exposure of said cavities to the ambient air nor that there are no differences even more, in models of infections severe periteonal, it was possible to attenuate the diathermic inflammatory response after washing the peritoneal cavity, with our solution so I also claim its use.

6. - Washing fruit and vegetables in post-harvest and packaging, the product is not only for medical applications but its spectrum as a bactericide and fungicide goes beyond the barriers of science to go to its application to the industry in agriculture in the production and storage of carnicol products of different species, so I claim its use in the washing of fruits and vegetables after harvest and packaging with what has been achieved the decrease in the amount of germs that usually contaminate them secondary to uncontrolled irrigation techniques such as It happens in the majority of the crops of alfalfa, radish, green beans, etc., in which E COLI, SALMONEYA, ENTERITIRIS AND LYSTERIA MONOSYTOGENES can be isolated, not only this, SIMO that, when washing the seeds of corn, the eradication of Aspergilluesniger, aparasitipusa, flavus these fungi, considered as freezers for the human, allowing to make a consumption of free aflatoxin, contaminant.

7. - The application of the SES, by ASPERSCION, to considerably reduce the degree of microbiological contamination of drug products, both of porcine, bovine, goat, chicken and fish origin, thereby eliminating the bacteria that condition the putrefaction of said products. products, allowing a longer shelf life.

8. - The super oxidized electrolyzed solution with neutral pH, with a concentration of 100 to 120 pem of free chlorine brought to a dilution of 1.10, has allowed the wastewater, after eliminating the solid receipts, to become a bacterially contained water. transmit its reuse for irrigation purposes and industrial SES, with neutral pH with a concentration of 100 120 of free chlorine brought to a dilution of 1:10 has allowed a total control of microorganisms in fruits and vegetables and vegetables in post harvest and packaging, the gel also shows antimicrobial activity in post-harvest and packaging so I claim the use of those items.

9. - Antiseptic in dental use, (SUPERIOR ELETROLYZED SOLUTION WITH PH NETRUO) the results in the washing processes of the dental canals in endodontic treatments and washing of periodental and odontogenic accesses, in washing and sterilization in its application shows extraordinary results in the processes of washing of the dental canals in the endodontic treatments in washing of periodontal accesses, and odontogenics in washing and sterilization of cavities before their filling, irrigation through the high pressure systems to avoid contamination during the dental treatments.

10. - It is healing and tissue regenerator, since it is shown that accelerates this process, reduces the amount of bacteria, which causes infection increases inflammation and tissue destruction, in addition by contacting the tissue electrolyzed solution super oxidized gel with higher oxygen concentrations to any other antiseptic, is why tissue regeneration is increased. Also when putting in contact with the tissues active ions of sodium, chlorine and oxygen, they are used by the cells that intervene in the inflammatory response to form and release reactive oxygen metabolites, which in addition to being the main anilíquidadores of the bacteria stimulate the release of sito quimioatractoras quinas, which bring wings to cells responsible for modulating the inflammatory response, also cause the activation of platelets to release platelet-dependent growth factor principal chemoattractant macrophages and fibroblasts, as well as generator of the extracellular matrix in which initiates the healing process in the inflammatory phase of the injury.

11. - I also claim its use as a healing material in deep superficial wounds, ulcers, cutaneous, chronic, both vascular and non-vascular origin.

12- I claim the process of sterilizing on inanimate objects, since the physical chemical process aimed at destroying all types of microorganisms that may exist on inanimate objects, considering the critical medical material as important is the medical and dental instruments, implants, probes and catheters. flexible rigid endoscope and all its accessories that penetrate into germ-free cavities by the use of my product and even prevents the entry of germs into the bloodstream.

13. - The super-oxidized electrolyzed solution when applied from 10 to 6 UF6 A UFC, is a fungicide, bactericidal, sporicidal and virucidal, that inhibits the growth of fungi and sterilizes by immersion of pararoscopic instruments, in addition to the study of said solution, its effectiveness of glutaraldohyde at 2% is compared, which is more effective with other products , since the super-oxidized letetrolized solution with neutral pH with the single ten-minute immersion will have more effective results than other products that exist in the market.

14. - Decontaminant and sanitizing., For cleaning industrial areas, sanitary sinks, pavements, bathroom furniture in toilet areas or food preparation eliminating microorganisms or infecting particles.

15. - Solution as an antiseptic, to be applied on epithelial surface destroys contaminating microorganisms without damaging the tissues. Its effect in the treatment of infected superficial heirs, in the washing of deep infections of the musculoskeletal system as in osteomenitis, in infections with circulatory alterations as in the case of gangrene also in infections of gangrene of foumier, is proved. It diminishes the penetration of the germs in the tissues this when using the super-oxidized electrolyzed solution, this happens when the active ions of my product are mixed with the proinflammatory and defensive factors of the human cells.

16. - I claim the use of electrolyzed solution with neutral pH, as a disinfectant, since it is a chemically inert substance that destroys microorganisms when applied to any material, without deteriorating it.

17. -I claim the invention in its liquid phase is a germicide that destroys both great positive and large negative bacteria, likewise destroys both yeast and filamentous fungi, destroys virus with lipid envelope, as well as without it, which also has effects on bacteria and on spores, in its gel phase is a germicide that destroys both great positive and large negative bacteria, also destroys both yeast and filamentous fungi, destroys virus with lipid envelope, and without it, which also has effects on bacteria and spores.

18. - the super-oxidized electrolyzed solution with neutral pH, a claim that is a more powerful fungicide than the products that exist in the market, since as with other bacteria it produces oxidation of the fungal wall proteins, producing its death and eliminating simultaneously fungal spores.

19. -I claim the prolonged exposure given by the super-oxidized electrolyte solution of the netron ph in its gel phase, which allows to control cutaneous viral infections in mucous membranes, including varicella-zoster virus lesions and that controls ulcers in the cervix. , by the human papilloma virus, also destroys the elimination of particular viral in medical instruments, you can also use this gel as a lubricant of condoms to reduce viral infections during sexual activity, as well as the decrease in the transmission of human immunodeficiency virus (AIDS).

20. - Claim on its gel effect destroys the superoxidated electrolyzed solution of neutral ph in its semisolid (gelled) phase that has destructive effects on spores esporecida, in resistant microorganisms.

21. - claim of the superoxidated electrolyzed solution of the neutral ph in its liquid phase (which has a neutral pH, since its variability can be acid or base very stable, and its small oxila range of 6.8 to 7.5 said solution can be applied as a disinfectant to any type of inert surface without damaging it or producing corrosion, which makes it a high-level disinfectant.

22. - reclamation claim of the superoxidated electrolyzed solution of the neutral ph in its liquid phase, as a bactericide, since it prevents it from conserving the intracellular ionic composition and which acts by producing the oxidation of the amino acids of the bacteria network by modifying the structure of the wall cellular, avoiding that its intracellular ionic composition is conserved with what damages vital processes, irreversibly for the microorganism, producing alteration in the oxidative phosphorylation process altering the bacterial respiration and denaturing the DNA that makes the generation of resistant organisms impossible.