MXPA05008148A - Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transformante (tgf). - Google Patents
Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transformante (tgf).Info
- Publication number
- MXPA05008148A MXPA05008148A MXPA05008148A MXPA05008148A MXPA05008148A MX PA05008148 A MXPA05008148 A MX PA05008148A MX PA05008148 A MXPA05008148 A MX PA05008148A MX PA05008148 A MXPA05008148 A MX PA05008148A MX PA05008148 A MXPA05008148 A MX PA05008148A
- Authority
- MX
- Mexico
- Prior art keywords
- tgf
- growth factor
- transforming growth
- inhibitors
- fused heteroaromatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
Se describen nuevos compuestos heteroaromaticos condensados, incluidos sus derivados, intermedios para su preparacion, composiciones farmaceuticas que los contienen y su uso medicinal. Los compuestos de la presente invencion son potentes inhibidores de la ruta senalizadora del factor de crecimiento transformante ("TGF")-(. Son utiles en el tratamiento de enfermedades relacionadas con TGF-( incluidas, por ejemplo, cancer y enfermedades fibroticas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45168303P | 2003-03-04 | 2003-03-04 | |
PCT/IB2004/000532 WO2004078110A2 (en) | 2003-03-04 | 2004-02-23 | Fused imizadoles as transforming growth factor (tgf) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05008148A true MXPA05008148A (es) | 2005-09-30 |
Family
ID=32962623
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05008148A MXPA05008148A (es) | 2003-03-04 | 2004-02-23 | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transformante (tgf). |
Country Status (14)
Country | Link |
---|---|
US (2) | US7417041B2 (es) |
EP (1) | EP1601676A2 (es) |
JP (1) | JP2006519249A (es) |
AR (1) | AR043449A1 (es) |
BR (1) | BRPI0407999A (es) |
CA (1) | CA2517933C (es) |
GT (1) | GT200400032A (es) |
MX (1) | MXPA05008148A (es) |
NL (1) | NL1025623C2 (es) |
PA (1) | PA8595001A1 (es) |
PE (1) | PE20050306A1 (es) |
TW (1) | TW200504069A (es) |
UY (1) | UY28214A1 (es) |
WO (1) | WO2004078110A2 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA80295C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Pyrazolopyridines and using the same |
UA80296C2 (en) * | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
JP4519657B2 (ja) * | 2002-09-18 | 2010-08-04 | ファイザー・プロダクツ・インク | 形質転換成長因子(tgf)阻害剤としての新規なピラゾ−ル化合物 |
CN1681805A (zh) * | 2002-09-18 | 2005-10-12 | 辉瑞产品公司 | 作为转化生长因子(tgf)抑制剂的新的咪唑类化合物 |
JP2008516962A (ja) * | 2004-10-15 | 2008-05-22 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 血管傷害を治療する方法 |
JPWO2006070943A1 (ja) * | 2004-12-28 | 2008-06-12 | 武田薬品工業株式会社 | 縮合イミダゾール化合物およびその用途 |
EP1928237A4 (en) * | 2005-09-02 | 2011-03-09 | Abbott Lab | NEW HETEROCYCLES BASED ON IMIDAZO |
WO2007070866A2 (en) * | 2005-12-16 | 2007-06-21 | Alcon, Inc. | Control of intraocular pressure using alk5 modulation agents |
ME02736B (me) * | 2005-12-21 | 2017-10-20 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
US7790741B2 (en) * | 2006-10-06 | 2010-09-07 | Abbott Laboratories | Imidazothiazoles and imidazoxazoles |
SI3034075T1 (sl) | 2006-11-22 | 2018-12-31 | Incyte Holdings Corporation | Imidazotriazini in imidazopirimidini kot inhibitorji kinaze |
US20080249305A1 (en) * | 2007-03-27 | 2008-10-09 | Calderwood David J | Novel imidazole based heterocycles |
CN103214482B (zh) | 2007-04-03 | 2016-06-29 | 阵列生物制药公司 | 作为受体酪氨酸激酶抑制剂的咪唑并[1,2-a]吡啶化合物 |
WO2008133192A1 (ja) * | 2007-04-19 | 2008-11-06 | Takeda Pharmaceutical Company Limited | 縮合イミダゾール化合物およびその用途 |
CN101678014B (zh) * | 2007-05-21 | 2012-12-12 | Sgx药品公司 | 杂环激酶调节剂 |
WO2008150827A1 (en) * | 2007-05-29 | 2008-12-11 | Smithkline Beecham Corporation | Naphthyridine, derivatives as p13 kinase inhibitors |
US8188083B2 (en) * | 2007-06-28 | 2012-05-29 | Abbott Laboratories | Triazolopyridazines |
CN101878219B (zh) * | 2007-09-27 | 2014-04-02 | 西班牙国家癌症研究中心 | 用于作为蛋白激酶抑制剂使用的咪唑并噻二唑类 |
CA2732186A1 (en) | 2008-07-29 | 2010-02-04 | Merck Patent Gmbh | Imidazothiadiazole derivatives |
DK2414369T3 (en) | 2009-04-02 | 2015-09-21 | Fundacion Ct Nac Investigaciones Oncologicas Carlos Iii | Imidazo [2,1-b] [1,3,4] thiadiazole derivatives |
FR2945289A1 (fr) * | 2009-05-11 | 2010-11-12 | Sanofi Aventis | Derives de 2-cycloamino-5-(pyridin-4-yl)imidazo°2,1-b! °1,3,4!thiadiazole, leur preparation et leur application en therapeutique |
WO2011047320A2 (en) | 2009-10-16 | 2011-04-21 | Rib-X Pharmaceuticals, Inc. | Antimicrobial compounds and methods of making and using the same |
MX2012004990A (es) | 2009-10-30 | 2012-06-12 | Janssen Pharmaceutica Nv | Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10. |
CN102781930B (zh) | 2009-12-18 | 2016-03-23 | 田边三菱制药株式会社 | 抗血小板药 |
AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
EP2723744B1 (en) | 2011-06-27 | 2016-03-23 | Janssen Pharmaceutica, N.V. | 1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES |
PL2731949T3 (pl) | 2011-07-13 | 2018-10-31 | Tiumbio Co., Ltd. | 2-pirydylo podstawione imidazole jako inhibitory alk5 i/lub alk4 |
CN104520422B (zh) | 2012-05-30 | 2019-08-23 | 康奈尔大学 | 由人羊水来源的细胞生成功能性的和持久的内皮细胞 |
JP6426603B2 (ja) | 2012-06-26 | 2018-11-21 | ヤンセン ファーマシューティカ エヌ.ベー. | 神経障害または代謝障害の治療に使用するための、1−アリール−4−メチル−[1,2,4]トリアゾロ[4,3−a]−キノキサリン化合物などのPDE2阻害剤とPDE10阻害剤との組合せ |
EP2869822B1 (en) | 2012-07-09 | 2016-09-14 | Janssen Pharmaceutica, N.V. | Inhibitors of phosphodiesterase 10 enzyme |
US20140120116A1 (en) * | 2012-10-26 | 2014-05-01 | The Chinese University Of Hong Kong | Treatment of cancer using smad3 inhibitor |
AU2014275130B2 (en) | 2013-06-05 | 2019-09-12 | Reverse Bioengineering, Inc. | Compositions and methods for induced tissue regeneration in mammalian species |
ES2813875T3 (es) | 2014-01-01 | 2021-03-25 | Medivation Tech Llc | Compuestos y procedimientos de uso |
US11078462B2 (en) | 2014-02-18 | 2021-08-03 | ReCyte Therapeutics, Inc. | Perivascular stromal cells from primate pluripotent stem cells |
US10240127B2 (en) | 2014-07-03 | 2019-03-26 | ReCyte Therapeutics, Inc. | Exosomes from clonal progenitor cells |
WO2016081364A1 (en) * | 2014-11-21 | 2016-05-26 | Rigel Pharmaceuticals, Inc. | Fused imidazole derivatives as tgf-beta inhibitors |
AR103232A1 (es) | 2014-12-22 | 2017-04-26 | Bristol Myers Squibb Co | ANTAGONISTAS DE TGFbR |
CN107922418A (zh) | 2015-03-11 | 2018-04-17 | 梅琳塔治疗公司 | 抗微生物化合物及制备和使用所述化合物的方法 |
EP3894401A2 (en) | 2018-12-11 | 2021-10-20 | Theravance Biopharma R&D IP, LLC | Naphthyridine and quinoline derivatives useful as alk5 inhibitors |
IL293084A (en) * | 2019-11-22 | 2022-07-01 | Theravance Biopharma R& D Ip Llc | 5,1-Converted naphthyridines or quinolines as alk5 inhibitors |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE640616A (es) * | 1962-12-19 | |||
US3492397A (en) * | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
US4060598A (en) * | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
ZW24186A1 (en) | 1985-12-12 | 1987-07-08 | Smithkline Beckman Corp | Inhibition of the 5-lipoxygenase pathway |
US5002941A (en) | 1985-12-12 | 1991-03-26 | Smithkline Beecham Corporation | Pyrrolo(1,2-a)imidazole and imidazo(1,2-a)pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors |
US4719218A (en) * | 1985-12-12 | 1988-01-12 | Smithkline Beckman Corporation | Pyrrolo[1,2-a]imidazole and pyrrolo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitor |
IL83467A0 (en) | 1986-08-15 | 1988-01-31 | Fujisawa Pharmaceutical Co | Imidazole derivatives,processes for their preparation and pharmaceutical compositions containing the same |
MY103766A (en) * | 1987-09-02 | 1993-09-30 | Smithkline Beckman Corp | Pyrrolo[1,2-a]imidazole and imidazo[1,2-a] pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors |
US5656644A (en) * | 1994-07-20 | 1997-08-12 | Smithkline Beecham Corporation | Pyridyl imidazoles |
WO1996030347A1 (en) | 1995-03-30 | 1996-10-03 | Pfizer Inc. | Quinazoline derivatives |
BR9809451A (pt) | 1997-05-22 | 2000-06-20 | Searle & Co | Pirazóis substituìdos com 3(5)-heteroarila como inibidores de quinase p38. |
AU7726898A (en) | 1997-05-22 | 1998-12-11 | G.D. Searle & Co. | Pyrazole derivatives as p38 kinase inhibitors |
US6514977B1 (en) | 1997-05-22 | 2003-02-04 | G.D. Searle & Company | Substituted pyrazoles as p38 kinase inhibitors |
WO2000061576A1 (en) | 1999-04-09 | 2000-10-19 | Smithkline Beecham Corporation | Triarylimidazoles |
CO5271680A1 (es) | 2000-02-21 | 2003-04-30 | Smithkline Beecham Corp | Compuestos |
GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
PE20020506A1 (es) | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
WO2002040468A1 (en) | 2000-11-16 | 2002-05-23 | Smithkline Beecham Corporation | Compounds |
GB0027987D0 (en) | 2000-11-16 | 2001-01-03 | Smithkline Beecham Plc | Compounds |
GB0100762D0 (en) | 2001-01-11 | 2001-02-21 | Smithkline Beecham Plc | Novel use |
GB0102672D0 (en) | 2001-02-02 | 2001-03-21 | Glaxo Group Ltd | Compounds |
US20040087623A1 (en) | 2001-02-02 | 2004-05-06 | Gellibert Francoise Jeanne | Pyrazole derivatives against tgf overexpression |
JP2004521901A (ja) | 2001-02-02 | 2004-07-22 | グラクソ グループ リミテッド | Tgf阻害剤としてのピラゾール |
HUP0303415A2 (hu) * | 2001-03-09 | 2004-01-28 | Pfizer Products Inc. | Triazolopiridinek, mint gyulladásgátló anyagok és ezeket tartalmazó gyógyszerkészítmények |
MXPA03008142A (es) | 2001-03-09 | 2003-12-12 | Pfizer Prod Inc | Nuevos compuestos antiinflamatorios de bencimidazol. |
ATE304009T1 (de) * | 2001-04-04 | 2005-09-15 | Pfizer Prod Inc | Neue benzotriazole mit entzündungshemmender wirkung |
WO2003000682A1 (en) | 2001-06-25 | 2003-01-03 | Merck & Co., Inc. | (pyrimidyl)(phenyl)substituted fused heteroaryl p38 inhibiting and pkg kinase inhibiting compounds |
AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
JP2005539000A (ja) * | 2002-07-31 | 2005-12-22 | スミスクライン・ビーチャム・コーポレイション | Alk5阻害剤としての2−フェニルピリジン−4−イル誘導体 |
GB0217783D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Compounds |
UA80296C2 (en) | 2002-09-06 | 2007-09-10 | Biogen Inc | Imidazolopyridines and methods of making and using the same |
AU2003267087A1 (en) * | 2002-09-13 | 2004-04-30 | Merck & Co., Inc. | Fused heterobicyclo substituted phenyl metabotropic glutamate-5 modulators |
DE60327443D1 (de) | 2002-09-18 | 2009-06-10 | Pfizer Prod Inc | Neue oxazolverbindungen als inhibitoren des transforming growth factor (tgf) |
EA200500286A1 (ru) | 2002-09-18 | 2005-08-25 | Пфайзер Продактс Инк. | Новые изотиазольные и изоксазольные соединения в качестве ингибиторов трансформирующего фактора роста (тфр) |
CN1681805A (zh) * | 2002-09-18 | 2005-10-12 | 辉瑞产品公司 | 作为转化生长因子(tgf)抑制剂的新的咪唑类化合物 |
JP4519657B2 (ja) | 2002-09-18 | 2010-08-04 | ファイザー・プロダクツ・インク | 形質転換成長因子(tgf)阻害剤としての新規なピラゾ−ル化合物 |
AP2005003260A0 (en) | 2002-09-18 | 2005-03-31 | Pfizer Prod Inc | Novel triazole compounds as transforming growth factor (TGF) inhibitors. |
-
2004
- 2004-01-30 PA PA20048595001A patent/PA8595001A1/es unknown
- 2004-02-20 US US10/783,251 patent/US7417041B2/en not_active Expired - Fee Related
- 2004-02-23 CA CA002517933A patent/CA2517933C/en not_active Expired - Fee Related
- 2004-02-23 WO PCT/IB2004/000532 patent/WO2004078110A2/en active Application Filing
- 2004-02-23 BR BRPI0407999-0A patent/BRPI0407999A/pt not_active IP Right Cessation
- 2004-02-23 EP EP04713609A patent/EP1601676A2/en not_active Withdrawn
- 2004-02-23 JP JP2006506271A patent/JP2006519249A/ja active Pending
- 2004-02-23 MX MXPA05008148A patent/MXPA05008148A/es active IP Right Grant
- 2004-03-01 PE PE2004000223A patent/PE20050306A1/es not_active Application Discontinuation
- 2004-03-02 GT GT200400032A patent/GT200400032A/es unknown
- 2004-03-02 UY UY28214A patent/UY28214A1/es not_active Application Discontinuation
- 2004-03-02 AR ARP040100654A patent/AR043449A1/es not_active Application Discontinuation
- 2004-03-03 TW TW093105533A patent/TW200504069A/zh unknown
- 2004-03-03 NL NL1025623A patent/NL1025623C2/nl not_active IP Right Cessation
-
2008
- 2008-07-23 US US12/178,160 patent/US20080275235A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7417041B2 (en) | 2008-08-26 |
UY28214A1 (es) | 2004-09-30 |
CA2517933A1 (en) | 2004-09-16 |
US20080275235A1 (en) | 2008-11-06 |
US20040176390A1 (en) | 2004-09-09 |
AR043449A1 (es) | 2005-07-27 |
CA2517933C (en) | 2009-05-12 |
BRPI0407999A (pt) | 2006-03-07 |
PE20050306A1 (es) | 2005-05-16 |
WO2004078110A3 (en) | 2004-11-11 |
GT200400032A (es) | 2004-10-21 |
NL1025623A1 (nl) | 2004-09-07 |
WO2004078110A2 (en) | 2004-09-16 |
PA8595001A1 (es) | 2004-09-28 |
TW200504069A (en) | 2005-02-01 |
NL1025623C2 (nl) | 2005-03-14 |
EP1601676A2 (en) | 2005-12-07 |
JP2006519249A (ja) | 2006-08-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MXPA05008148A (es) | Nuevos compuestos heteroaromaticos condensados que son inhibidores del factor de crecimiento transformante (tgf). | |
MXPA05009245A (es) | Nuevos compuestos de pirazina como inhibidores del factor de crecimiento transformante (tgf). | |
CA2498047A1 (en) | Novel imidazole compounds as transforming growth factor (tgf) inhibitors | |
WO2004026306A3 (en) | Pyrazole derivatives as transforming growth factor (tgf) inhibitors | |
WO2004026863A8 (en) | Novel oxazole and thiazole compounds as transforming growth factor (tgf) inhibitors | |
NO20051010L (no) | Triazolderivater som transformerende vekst faktor (TGF) inhibitorer | |
NO20051852L (no) | Nye isotiazol- og isoksazolforbindelser samt transformerende vekstfaktor (TGF)-inhibitorer. | |
MY129422A (en) | Medicinal compounds | |
NZ516347A (en) | Indanyl-substituted benzenecarboxamides, process for their preparation, their use as a medicament and pharmaceutical formulations containing them | |
PL1687305T3 (pl) | Pochodne 1H-imidazochinolin jako inhibitory kinaz białkowych | |
RS60503A (en) | Substituted alkylamine derivatives and methods of use | |
GB0112348D0 (en) | Compounds | |
ES2187300A1 (es) | Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos. | |
WO2005037798A3 (en) | Amide or thiomide derivatives and their use in the treatment of pain | |
ES2193875A1 (es) | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. | |
SI1727817T1 (sl) | Azabiciklooktan-3-onski derivati in njihova uporaba | |
IL160171A0 (en) | Depsipeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same | |
MEP42908A (en) | Substituted 4-phenyltetrahydroisoquinolines, method for the production thereof, the use of the same as medicaments, and medicament containing such compounds | |
MY139613A (en) | Novel piperazinyl-pyrazinone derivatives for the treatment of 5-ht2a receptor-related disorders | |
AP2002002572A0 (en) | Novel substituted pyrazol(4,3-e) diazepines, pharmaceutical compositions containing them, as medical products and processes for preparing them | |
PE20030236A1 (es) | Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados | |
EA200100876A2 (ru) | Фармацевтическая композиция для предупреждения или лечения заболевания, связанного с избыточным продуцированием il-12 | |
HK1097548A1 (en) | Novel indeno | |
DOP2003000712A (es) | Nuevos compuestos de triazol como inhibidores del factor de crecimiento transformante (tgf) | |
MY135855A (en) | "pyrrolopyrimidinone derivatives, process of preparation and use" |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |