MXPA02012034A - Derivados de tiofeno utiles como agentes anticancerosos. - Google Patents

Derivados de tiofeno utiles como agentes anticancerosos.

Info

Publication number
MXPA02012034A
MXPA02012034A MXPA02012034A MXPA02012034A MXPA02012034A MX PA02012034 A MXPA02012034 A MX PA02012034A MX PA02012034 A MXPA02012034 A MX PA02012034A MX PA02012034 A MXPA02012034 A MX PA02012034A MX PA02012034 A MXPA02012034 A MX PA02012034A
Authority
MX
Mexico
Prior art keywords
anticancer agents
derivatives useful
thiophene derivatives
compounds
formula
Prior art date
Application number
MXPA02012034A
Other languages
English (en)
Inventor
Michael Joseph Luzzio
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MXPA02012034A publication Critical patent/MXPA02012034A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

El invento se refiere a compuestos de formula 1; (Ver formula). y a sales e hidratos farmaceuticamente aceptables de los mismos, formula en la que X, Y, R1, R2 y R11son como aqui se definen. El invento se refiere tambien a composiciones farmaceuticas que contienen los compuestos de formula 1, ya metodos para tratar trastornos hiperproliferativos en un mamifero mediante la administracion de los compuestos de formula 1.
MXPA02012034A 2000-06-06 2001-05-02 Derivados de tiofeno utiles como agentes anticancerosos. MXPA02012034A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20968600P 2000-06-06 2000-06-06
PCT/IB2001/000766 WO2001094353A1 (en) 2000-06-06 2001-05-02 Thiophene derivatives useful as anticancer agents

Publications (1)

Publication Number Publication Date
MXPA02012034A true MXPA02012034A (es) 2003-04-25

Family

ID=22779830

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA02012034A MXPA02012034A (es) 2000-06-06 2001-05-02 Derivados de tiofeno utiles como agentes anticancerosos.

Country Status (22)

Country Link
US (1) US6964961B2 (es)
EP (1) EP1287001B1 (es)
JP (1) JP2003535867A (es)
AR (1) AR032621A1 (es)
AT (1) ATE277933T1 (es)
AU (1) AU2001252463A1 (es)
BR (1) BR0111377A (es)
CA (1) CA2411084A1 (es)
DE (1) DE60106022T2 (es)
DO (1) DOP2001000170A (es)
EC (1) ECSP014097A (es)
ES (1) ES2223827T3 (es)
GT (1) GT200100104A (es)
MX (1) MXPA02012034A (es)
PA (1) PA8518701A1 (es)
PE (1) PE20011373A1 (es)
PT (1) PT1287001E (es)
SV (1) SV2002000478A (es)
TN (1) TNSN01082A1 (es)
TR (1) TR200402656T4 (es)
UY (1) UY26750A1 (es)
WO (1) WO2001094353A1 (es)

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EP1483268A2 (en) 2002-03-01 2004-12-08 Pfizer Inc. Indolyl-urea derivatives of thienopyridines useful as anti-angiogenic agents
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UA77303C2 (en) * 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
US7488823B2 (en) * 2003-11-10 2009-02-10 Array Biopharma, Inc. Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors
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UA81453C2 (en) 2003-02-27 2008-01-10 Pyrazolopyridine derivates
EP1620094A4 (en) * 2003-05-06 2010-04-28 Glaxosmithkline Llc NEW CHEMICAL COMPOUNDS
KR101028952B1 (ko) 2003-08-14 2011-04-12 어레이 바이오파마 인크. 수용체 티로신 키나아제 억제제로서의 퀴나졸린 유사체
US7501427B2 (en) 2003-08-14 2009-03-10 Array Biopharma, Inc. Quinazoline analogs as receptor tyrosine kinase inhibitors
US7459562B2 (en) 2004-04-23 2008-12-02 Bristol-Myers Squibb Company Monocyclic heterocycles as kinase inhibitors
TW200538453A (en) 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7432373B2 (en) 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
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CN101031570B (zh) 2004-07-30 2012-09-05 梅特希尔基因公司 Vegf受体和hgf受体信号的抑制剂
US8093264B2 (en) 2005-05-20 2012-01-10 Methylgene Inc. Fused heterocycles as inhibitors of VEGF receptor and HGF receptor signaling
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WO2007035428A1 (en) 2005-09-15 2007-03-29 Bristol-Myers Squibb Company Met kinase inhibitors
PE20070619A1 (es) * 2005-09-27 2007-07-02 Wyeth Corp TIENO(2,3-b)PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINAS QUINASA
US7547782B2 (en) 2005-09-30 2009-06-16 Bristol-Myers Squibb Company Met kinase inhibitors
CA2755268C (en) 2005-11-15 2013-12-31 Array Biopharma, Inc. Erbb inhibitors
TW200806675A (en) * 2006-01-30 2008-02-01 Array Biopharma Inc Heterobicyclic thiophene compounds and methods of use
EP2137177B1 (en) 2007-04-05 2014-05-07 Amgen, Inc Aurora kinase modulators and method of use
BRPI0923670A2 (pt) 2008-03-05 2013-07-30 Methylgene Inc inibidores da atividade de proteÍna tirosina quinase e seu uso, bem como composiÇço compreendendo os mesmos
MX2010010151A (es) 2008-03-20 2010-10-25 Amgen Inc Moduladores de cinasa aurora y metodo de uso.
US9126935B2 (en) 2008-08-14 2015-09-08 Amgen Inc. Aurora kinase modulators and methods of use
PL2355822T3 (pl) 2008-11-19 2013-03-29 Envivo Pharmaceuticals Inc Leczenie zaburzeń funkcji poznawczych (R)-7-chloro-N-(chinuklidyn-3-ylo)benzo[b]tiofeno-2-karboksyamidem i jego farmaceutycznie dopuszczalnymi solami
JP5808319B2 (ja) * 2009-05-11 2015-11-10 フォルム ファーマシューティカルズ、インコーポレイテッド アセチルコリンエステラーゼ阻害剤と組み合わせた特定のα７ニコチン酸受容体を用いた認知障害の治療
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EP2846796A4 (en) 2012-05-08 2015-10-21 Forum Pharmaceuticals Inc METHODS OF MAINTAINING, PROCESSING OR ENHANCING COGNITIVE FUNCTION
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Also Published As

Publication number Publication date
EP1287001A1 (en) 2003-03-05
CA2411084A1 (en) 2001-12-13
US6964961B2 (en) 2005-11-15
UY26750A1 (es) 2002-01-31
ES2223827T3 (es) 2005-03-01
PA8518701A1 (es) 2002-09-17
AR032621A1 (es) 2003-11-19
BR0111377A (pt) 2003-06-03
DE60106022T2 (de) 2006-03-09
ECSP014097A (es) 2003-02-06
WO2001094353A1 (en) 2001-12-13
US20020042409A1 (en) 2002-04-11
TR200402656T4 (tr) 2004-11-22
TNSN01082A1 (fr) 2005-11-10
DE60106022D1 (de) 2004-11-04
GT200100104A (es) 2002-01-31
PT1287001E (pt) 2004-12-31
ATE277933T1 (de) 2004-10-15
PE20011373A1 (es) 2002-01-18
DOP2001000170A (es) 2002-05-15
JP2003535867A (ja) 2003-12-02
AU2001252463A1 (en) 2001-12-17
SV2002000478A (es) 2002-07-03
EP1287001B1 (en) 2004-09-29

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