MXPA00011983A - Direct dual filling device for sealing agents - Google Patents

Abstract

A filling device (10) and method particularly for two component sealants such as fibrin sealants, which enable two fluids to be separately, directly filled to the reservoirs of a dual syringe fluid applicator (22) from two storage containers (28, 29), which can be standardized, sealed, sterilized bottles.

Description

DIRECT DUAL FILLING DEVICE FOR SEALANT AGENTS REMISSION OF APPLICATIONS This application discloses matters related to our co-pending International Patent Applications Nos PCT / US98 / 07 88 and PCT / US98 / 0784Ó both dated April 14, 1998, the disclosure of these applications, 'the above mentioned applications' are incorporated with the same reference BACKGROUND OF THE INVENTION 1. FIELD OF THE INVENTION This invention relates to a filling device for an applicator that applies multiple liquid sealing components on a work surface and particularly, although not exclusively, useful in the application of tissue sealing elements in biological tissue to achieve haemostasis or obtain other therapeutic results. In particular, it refers to a dual compartment included directly with the filling device in a manual apdor 2 Description of the Environment that Includes Information Published in 37 CFR 1.97 and 37 CFR 1.98.

The use of tissue sealants and other biological materials is an important surgical technique in the process of development, adaptable to the surgery room or to medical offices or mobile medical units. The most preferred sealants include fibrin sealants that are formed by plasma components. and, on the one hand, include a first element that contains fibpnogen and XHI Factor in addition to a second element that usually includes calcium ions and thrombin. Fibrinogen is able to polymerize and bind to form a solid fibrin clot when these elements The other factors necessary to stimulate relevant parts of the natural cascade of blood coagulation are precisely distributed between the fibpnogenic elements and the thrombins.

Antanavich et al U.S. Patent No. 5,585,007, the disclosure and references of which are incorporated herein, extensively discuss the literature related to the preparation of fibpnogenic sealants (column 1, line 20 to column 4, line 62) and the column of applicators 4 line 62 to column 5, line 14), as well as a bibliography, (columns 6-10) and is a useful teaching guide to know the subject before working with it Depending on the power of the formula used, the coagulation of the sealant can be very tapida, creating a gel in a lapse of 10 to 20 seconds and despite being a desirable solution in qunuigicas situations, these properties of action r fast They present potential problems such as obstruction and coagulation. These problems can be solved by means of applicators, application methods and suitable devices to fill said applicators.

The most popular manual applicator of these sealing elements employs a double syringe connected by a clamp, each containing a space to store each of the elements In the old devices the sealing elements are discharged in separate streams and mixed externally The operation of these applicators is similar to the Silicon guns used in the home Since May 1998, when the FDA first approved these products, fibrin sealants were not commercially available, so the use of fibrin sealants was limited to the supplies produced within the clinics, being out of control of the FDA As taught in the US Patent No. 5,266,877 and in our international applications PCT / US98 / 07846, the sealant components can be placed in separate compartments in a flat filling tray for transfer to a dispenser. Although it is useful for a device to allow filling When using a dual syringe dispenser at the time of use, these filling trays are not suitable for the extemal storage of sealing components. This process can take a long time and requires a significant degree of care to efficiently transfer the sealant to the cleaner Also, a small amount of sealant will remain in the tray, becoming a waste In addition, the transfer of the sealing components to a multiple storage container increases the possibility of the sealant becoming contaminated with bacteria, which can threaten the sterility of the sealant However, after FDA approval, fibrin sealants are commercially available in the United States. This availability has created the need for an effective and efficient device to transfer sealant components.

According to this there is a need for a device that can effectively release, in a sterile environment, multiple sealing components directly from its storage container to the applicator SUMMARY OF THE INVENTION This invention solves the problem of effectively applying multiple sealing compounds directly from commercial or standardized packaging, for example, from a fiasco to the applicator while allowing the use of a complete filling device within a sterile environment On the one hand the invention contains a dual direct filling device for multiple liquid sealing elements at least two of which are complementary and polimepzan when joining the direct filling device contains a body having a plurality of input ports connected to tubes of extraction that can pierce the protective cover of commercial bottles containing commercial sealing elements The device also has a hook that is gripped to the base to join the bottle to the structure allowing the device to be in a sterile environment This base has slanted supports that hold the bottle in an inclined position with a lower point of each volume of the bottle aligned under each respective extractor tube This feature allows the extractor tubes to extract virtually all the liquid contained in the bottles This device can be attached to an applicator with keys that when the plunger of the apl When the liquid is withdrawn, the liquid is led from each respective bottle to the corresponding receptacle inside the applicator The invention allows multiple sealing elements to be released directly from commercial containers into a dispenser without a significant risk of contamination of the sealing elements and with minimal waste of sealing elements. Different sealing elements are released directly from their containers in individual receptacles. separated without contamination thus preventing the coagulation of the sealing elements Once the hook of the device It is introduced into the bottle and is attached to the base, the entire device can be driven to a sterile environment BRIEF EXPLANATION OF THE DRAWINGS One of the ways to carry out this invention is described in detail with reference to the drawings that illustrate one or more of the structures of the invention and where Figure 1 is an elevated side view of a dual direct fill device connected to an applicator according to the present invention, Figure 2 is a side elevational side enlarged view of the present invention, Figure 3 is a view of the present invention throughout the lines 3 3 of figure 2, figure 4 is a top view of the present invention, figure 5 is a perspective view of the present invention figure 6 is a perspective view of a dual direct filling device connected to an appliance according to an alternative embodiment of the present invention Figure 7 is an amplified view of an alternative embodiment of the present invention, Figure 8 is a high sectional view of an alternative embodiment of the present invention, Figure 9 is an elevational view of an alternative embodiment of the present invention, Figure 10 is an elevational view of an alternative embodiment of the present invention, Figure 10a is a partial raised view showing the bottle holder, Figure 11 is an elevational view of an alternative embodiment of the present invention, Figure 12 is a cut-away view showing the hook going down into the base during accommodation, and Figure 13 is a cropped view showing the extraction tube held in place. for a guide DESCRIPTION OF PREFERRED INCORPORATIONS With reference to Figures 1 and 2 of the drawings, the dual direct fill device 10 comprises a body 12, a hook 14 and a collar 16 which is adapted to be accommodated in the applicator 18. The device of the invention is preferably constructed of a Tepnoplastic material such as pohcarbonate, polystyrene, polypropylene, polytetrafluorostylene, styrene-butadiene acploruitpleno or aerifico, however it can be used any other suitable material The applicator 18 preferably has at least two receptacles of liquid to separately hold and controlly dispatch the activating liquids, each of the liquid receptacles will be connected to a syringe by a liquid conduit. The liquid can be expelled and conducted into the receptacles. when operating the plunger 19. The tampon is of the type primarily used to apply multiple liquid sealing elements to a biological tissue to effect hemostasis or achieve other therapeutic results. However, the filling device of this invention can be adapted to accommodate the applicators having a variety of uses that require the direct filling of liquids in separate receptacles located in an applicator Located inside the body 12 are the inlet ports 20 and 21 which are adapted to receive the syringes 22 and 23 of the puncher 18 The rubber O-rings 34 and 35 are placed in the inlet ports 20 and 21 respectively, in such a way that an airtight seal is achieved. The inlet ports 20 and 21 are connected to the extractor tubes 24 and 25 by transverse channels 26 and 27 respectively, which extractor tubes 24 and 25 extend into the bottles 28 and 29. The channels 26 and 27 have a length sufficient to provide a desired separation between the extractor tubes 24 and 25 The extractor tubes 24 and 25 must be of sufficient length to extract substantially all of the liquid contained in the bottle, or else they should be of a length such that when the system is reversed substantially all the liquid is removed. The extractor tubes 24 and Preferably they should have pointed ends 30 and 31 which have the ability to pierce the protective packing found in the commercial bottles 28 and 29 The extractor tubes 24 and 25 are preferably formed of a metallic material, however any other material can be used as well as the thermoplastic The tubes must also have the ability to be removed from the support sleeves 32 and 33 for replacement The channel 26 allows the liquid contained in the right bottle 28 to be led through the tube 24 and into the syringe 22 to deposit within the suitable receptacle located in the puncher 18 without coming into contact with the bottle 29 Similarly, the channel 27 allows the liquid contained in the left bottle 29 to be led through the tube 25 and into the syringe 23 to deposit it in the suitable receptacle located inside the puncher 18 without coming into contact with the liquid contained in the bottle 28 This allows the simultaneous filling of both sides of the applicator directly from the commercial containers The channels 26 and 27 can be formed of thermoplastic tubes or molded directly into the body 12 of the direct filling device 10 To fill the puncher 18 directly from the bottles 28 and 29, the hook 14 is placed on said bottles in such a way that the pointed tips 30 and 31 are centered approximately in the center of the protective seal of the bottles The shape of the guide hook 14 the device of the invention while the bottles are placed in place with the hook 14 closing the members 40 As clearly shown in Figure 3, the closing members 40 are located within the hook 14 so that they move apart when the lid 42 or its respective bottles pass during the insertion of the bottle, then once the bottle has the proper position the closed members 40 retracts under the lid of the bottle 42 to close or "seal" the 10 bottles in place Once the bottles are placed the system can be inverted to remove more liquid from the bottles, depending on the length of the extractor tubes 24, 25 The piston 19 of the puncher 18 is retracted thereby pulling the liquid contained in the bottles 18 and 29 through their respective extractor tubes and channels towards the syringes of the puncher 18 to deposit them in the receptacle The direct filling device 10, as shown in Figure 4, is connected to the applicator 18 by a pair of members 36. The puncher 18 is placed over the filling device in such a way that the syringes are centered approximately on the ports of Entitled 22 and 23, then they are pushed down until they are put in place using the accommodating toothed members 36 The novel shape of the collar 16 allows the filling device 10 to fit the applicator 18 in a single orientation The general shape of the pentagon fits precisely into the body of the dispenser in the same manner as interchangeable applicators or heads, which are used to spray or drop the sealant The feature of adjusting the neck of the filling device to the applicator ensures that the proper fibrin elements are applied in their respective receptacles without incurring a significant risk or cross-contamination, particularly when being filled, making bottles 28 and 29 the respective suitable positions with the hook 14, which can be facilitated by certain characteristics of structures of the invention, as will be discussed below As shown in Figure 5, the bottle 29 is inserted into the hook 14 until the members 40 seal it. As can clearly be seen, the hook 14 has a cavity 44 which helps the user to remove the bottles. The cavity 44 is also useful, if the hook 14 is opaque, to see the label of the bottle to be able to verify that the suitable elements are applied in the suitable receptacles It is also shown in the figure of the hook 14 This figure can vary to allow the use of different types and shapes of jars The hook can also be modified so that each end allows the insertion of different forms of jars, thus locating the jars to the filling device. This in conjunction with the novelty form of the collar is important to ensure that the appropriate elements are released in the jars. suitable receptacles of the apheador The dual direct fill device shown in Figures 6-11 is a more detailed embodiment of the invention that includes most of the features shown in the embodiment of Figures 1-5 and is suitable for fabrication with moldable plastic elements. As will be described , vain of the parts of the dual direct fill device shown in Figures 6-11 contains a similar construction and functionality of the components of the embodiment shown in Figures 1-5 Many individual structure features of the dual direct fill device can be seen in the enlarged view of Figure 7, while Figures 8-13 show characteristics of additional structures and relationships of the internal components and Figure 6 shows the external complete appearance of the dual device of direct filling in use Referring to Figure 7, the dual direct fill device 100, shown in an enlarged view, comprises the hook 102, having a first half 104 and a second half 106, a pair of extractor tubes 108 and 1 10, a pair of ducts of liquid 1 12 and 114 and a base 1 16 The half point 104 and the second half 102, of the hook 102 have a pair of guide tubes 118 and 120 and a pair of cavities 122 and 124 The base 116 has a pal e supports for bottles 126 and 128 that are configured to support the bottles 130 and 132 In addition, each holder of the bottles 126 has a support surface for bottle 134 The hook 102 can be accommodated to conform to the shape of the filling device when it is attached to the agent bottles The shape can also be varied to allow the use of different types and shapes of jars The hook can be modified in such a way that each end permits the insertion of different jars shapes, achieving the accommodation of the jars in the filling device This in conjunction with the novelty shape of the collar is important to ensure that the proper elements are released into the appropriate receptacles of the applicator In the aforementioned embodiments, the hook 102 and the base 116 are essentially rigid, injected molded elements having a limited strength in their thinnest sections. The hook 102 is preferably formed of a transparent plastic such as the pohcarbonate or SAN In contrast, the conduits of liquid 112 and 114 are preferably made of elastomer, a moldable and resistant material such as Sihcon rubber Once accommodated the hook 102 is configured to conform to the base 116 using the accommodating toothed members 1 1 1 The hook 102 and the base 1 16 are configured in such a way that they can only be accommodated in one direction, therefore, in use the operator can not accommodate the device correctly Base 1 16 and the hook 102 also have a color code to indicate which side is for the thrombin bottle and which side is for the fibpnogen bottle. Furthermore, base 116 is labeled with a "T" indicating the side of the thrombin and with an 'F' indicating the fibpnogen side When accommodated, the upper portions of the first half 104 and the second half 106 combine to form a collar 136, conforming to the characteristics of the collar 16 A pair of channels 137 having inlet ports 140 and 142 are also defined in the hook 102 Channels 137 are configured to retain liquid conduits 112 and 114 The liquid conduits 112 and 114 comprise a cylindrical cup 144 and a tubular arm 146, which accommodate the channel 137. The cups 144 are internally configured to be pressed in a hermetically sealed gear, when they are molded to the syringes 22 and 23 of the applicator 18, with the ends of the syringes of the sealing elements placed in a combinable attaching body, to receive the liquid elements The tubular arms 146 of the liquid conduits 1 12 and 1 14 are flexible and can actually be manipulated during the assembly of the filling device 102 The ends of the tubular arms 146 are configured to accommodate the ends of the extractor tubes 108 and 1 10 respectively. This configuration allows the liquid elements to be brought to the tube 108 inside the conduit 1 12 and stored in the receptacle respective located in the applicator 18 Similarly, the liquid elements can be conducted through the tube 1 10 to the liquid conduit 114 and stored in another receptacle located in the applicator 18 without lesser pollution risk Once assembled, the filling device provides an interface tightness of the extractor tubes to the receptacle of the aphcador The extractor tubes 108 and 1 10 should be of sufficient length to reach substantially the deepest point of the co-compacting bottle. The extractor tubes 108 and 110 are preferably configured with a tip end having the ability to pierce the protective seal located in the bottles of medical liquids The extractor tubes 108 and 110 generally look like a needle, and preferably are formed of a metallic material, however any material can be used, for example the thermoplastic. Both tubes can have the similar diameter, however the diameter of the tube can differ for accommodate liquids that have different viscosities The guide tubes 1 18 and 120 are hinged in the cavities 122 and 124 so that they can be coupled with the cavities when the filling device is in use. Figure 13 illustrates the manner in which the extractor tube is put in place by the extractor tubes guide 1 18 Each of the guides has a fork end 1 19 that when used in conjunction with another holds the tube Extraction 118 in vertical position Cavities 122 and 124 must be sized to allow variation of the position of the guide, when stored The collar 136 is connected to the puncher 18 by a pair of accommodating toothed members 138. The applicator 18 is positioned on the dual direct fill device 100 such that the syringes of the puncher 18 are centered approximately on the inlet ports 140 and 142., then pushed until they are in place using the serrated accommodation members 138 Alternatively, the collar 136 may be configured without the toothed fitting members 138 Due to the stability of the device when it is armed, the applicator 18 may be held in place by a combination of gravity and friction generated by the nature of the seal formed between the syringes and the liquid conduits The novel shape of the collar 136 allows the direct filling dual device 100 to accommodate the puncher 18 in a single orientation, thus fitting the filling device with the applicator The general shape of the pentagon fits precisely in the body of the applicator in the same way as the interchangeable tips or heads of the applicator, which are used to discharge the sealant in spray or drops This way of fitting the collar of the filling device to the applicator ensures that the fibrin elements are applied in their resp ectives receptacles without incurring a significant risk of a contaminated contamination and the resulting loss of contaminated matepales As shown in Figure 8, the first half 104 of the hook 102 has a central division 148 that divides the hook into two compartments 150 and 152, which when the hook 102 is accommodated, enter the bottles 130 and 132 respectively. The compartment 150 it has an upper surface 154 which is inclined at its bottom in the division 148 to the upper part of the outer wall 156 Similarly, the compartment 152 has an upper surface 158 that is inclined from its lower part of the divider 148 to the wall highest external 160 The supports of the bottles 126 and 128 are separated by a divider slot 162 which is configured to receive the central divider 148 of the hook 102. The surface of the vial holder 134 has a toothed outer portion 164, a central portion 166 and an internal serrated surface. U-shaped The angle at which the internal and external parts of the surface of the bottle holder 132 is constructed, is substantially parallel to the upper toothed surface 154 and 158 of the hook 102. The surface of the bottle holder 134 has an opening that it has a width that allows the bottles 130 and 132 to be suspended by the necks as shown in figure 8 The assembly of the components of the filling device 100 can be done in a factory or in any other place that has that purpose before using the device of the invention. The extractor tubes 108 and 110 are accommodated with the arms. tubular 146 of the liquid conduits 1 12 and 1 14 The assembly is now accommodated with the channel 137 in such a way that the extractor tubes 108 and 1 10 are supported by guides 118 and 120 respectively. Preferably, one half of the channel 137 has the enough proportion to accommodate a larger portion of the liquid conduits 1 12 and 114 This allows the liquid conduits to be placed in the larger channel before accommodating the two halves, thus allowing greater strength of the conduits before assembling the two halves of the hook 102 Once the extractor tubes and liquid conduits are in place, the first half 104 and the second half 106 of the hook 102 are configured to be assembled together by the accommodating toothed members 105. Alternatively, ultrasonic welding, glue, pressure can be used. or any other method to assemble All the components of the device of the invention must be sterilized When the operator wishes to use the filling device he will only have to insert the bottles 130, 132 and arrange the hook in the base Generally, the bottles of agents are not sterilized and can not be carried to a sterilized medium without the risk of contamination. However, when agent fiascos are covered and sealed together with the filling device of the invention the assembly can be taken to a medium sterile and used The operator assembles the device by sliding the bottles of agents into the bottle holders 126 and 128 in such a way that the necks of the two bottles of agents rest on the surface of the bottle holder 134. The angle at which the outer part 164 of the support surface of the bottle 134 is configured, it will cause the two bottles of agent to slide in place resting the central portion 166 of the support surface of the bottle 134. The angle is such that the friction will not prevent the bottle from being placed in the central portion 166. As shown in Figure 10 a bottle 130 is suitably placed in the bottle holder 126 when the center line 180 of the bottle 130 is placed at a point in the central portion 166 furthest from the pivot fulcrum 182. The fulcrum of the pivot 182 occurs at the moment when the portion of level 166 is transformed within the internal support surface 168. This position allows the bottle 130 to hold firm. is in place by the holder 126, while still allowing the bottle 130 to rotate in the direction of the arrow 184. By allowing the bottle 130 to fully sit on the surface of the bottle holder 134, the bottle 130 will maintain the level position during the first part of the insertion of the extractor tube. This allows the needle to properly align with the septum area of the vial. Because the septum of the bottle has a thin portion in the center which allows the needles to prick it, it is desirable to align the extractor tube with the target area, assuming a clean perforation and a good seal.

Once the bottles 103, 132 are properly positioned, the hook assembly is placed on the base in such a way that the divider 148 is positioned together with the divider slot 162 as shown in Figure 9 as the hook assembly is lowered towards the base in the direction of the arrow 170, the divider 148 and the groove of the divider 162 act to align the extractor tubes 108 and 110 with the target area of the agent vials 130 and 132 While the assembly is lowered further towards the base in the direction of the arrow 170, the extractor tubes 108 and 110 pierce the septum of the agent bottles creating an airtight interface As indicated above the extractor tubes 108, 110 must be supported vertically through their guides and the vials of agents will be positioned correctly by the part of the holder of the bottle so that the extractor tubes pierce the target area of the septa As illustrated in Figure 12, when the guides 1 18 and 120 are brought into contact with the upper portion of the agent bottles 130 and 132 they are covered up and out of the path of the cavities 122 and 124 Figure 10 shows the point where the supepor portion of the bottles 130 and 132 come into contact with the upper surfaces 154 and 158 While the casing moves in the base in the direction of the arrow 170, the toothed configuration of the upper surface 154 causes the agent bottle 130 to tilt in the direction of the arrow 172 Similarly the toothed configuration of the supepor surface 158 causes the agent bottle 132 to tilt in the direction of the arrow 174 The bottles are tilted because the toothed internal surface of the jars of the bottle casings are pressed down towards the lid of each bottle, causing them to incline towards the same angle as the internal upper part of the cavity Simultaneously with the inclination of the agent bottles 130 and 132 the extraction tubes 108 and 110 are led to the deep corner of their respective bottles Ideally, their sharp tips of the extractor tubes are configured in such a way that they conform to the shape of the deep corner of the agent jars to get as much liquid as possible Once the assembly has been completed completely and is at the bottom of the base in the fully engaged position as in Figure 11, it can be put in place by the serrated ushers 11 1 The agent bottles 130 and 132 are inclined in such a way so that the extractor tubes 108 and 1 10 are pushed inward towards the deep corner of each respective bottle which has now become the bottom part so that the agent can be submerged This configuration together with the shape of the extractor tubes allow minimal waste of the agent contained in the jars Once the filling device of the invention is assembled it can be carried to a sterile medium. However, the agent bottles are generally not sterile and therefore are not allowed in a sterile environment because of the pollution hazard, the hook and seal assembly. The base has effectively coated the bottles in a sterile medium so they can be taken to a sterile medium Although only two bottles are shown for use in the filling device of the invention, one can easily make an adaptation to use three or more, which can directly fill three or more receptacles contained in the dispenser. Adaptation can be achieved by expanding the hook and adding another entrance port, a transverse channel and an extraction tube Although embodiments of the invention have been described above, it is, of course, understandable that various modifications are obvious to those skilled in the art. Many of these modifications are contemplated as an important part of the invention.

Claims (48)

1 - . 1 - A connector for connecting a dispensing instrument for multiple containers characterized by containing a) a body having a lower and a lower part, said upper part having an outer perimeter and a plurality of outgoing ports in said perimeter, said lower part having a plurality of input ports connected to said outgoing ports where each port of the inlet is connected to one of the said output ports by an internal diameter in said body, b) a collar extending from said perimeter, said collar adapted to receive said dispensing instrument c) a plurality of tubes wherein each of said tubes is connected to one of said inlet ports and has a distal end to said inlet ports to extend within said containers, each end having an opening for conducting liquid, and d) a hook extending from said lower ark and adapted to receive simultaneously a plurality of containers in such a way that once the containers are located with said hook, said extensions of said tubes allow to conduct liquids simultaneously and separately in said dispensing instrument 2 The connector described in clause 1 is characterized in that said collar, said body and said hook are formed of thermoplastic materials The connector mentioned in clause 2 is characterized in that said thermoplastic is selected from a group consisting of pohcarbonate, polystyrene, polypropylene, polytetrafluoroethylene styrene butadiene acplonitplo and aerifico 4 The connector mentioned in clause 1 is characterized in that said collar, said body and said hook are formed by a single member of thermoplastic 5 The connector mentioned in clause 1 is characterized in that said tubes are formed of a metallic material The connector mentioned in clause 1 is characterized in that said collar fits into said dispensing instrument in such a way that said dispensing instrument can be accommodated in said connector in a single orientation The connector mentioned in clause 1 is characterized in that said hook contains a resistant matenal and is adjusted in such a way that when each said containers are placed within each said hook, said hook is formed resistently to accommodate and secure each of said containers in place The connector mentioned in clause 1 is characterized in that said hook also contains a closing member adapted to secure said containers in said connector The connector mentioned in clause 8 is characterized in that said closure member contains a resistant plastic attached to said hook and extends radially inwardly from said hook in such a way that when each of said containers is placed inside said member of said hook. closure, said closure member secures each of said containers in place The connector mentioned in clause 8 is characterized in that said closing member is ring-shaped inside said hook 1 1 The connector mentioned in clause 1 is characterized in that each of said output ports has a circular shape 12 The connector mentioned in clause 1 is characterized in that each of said internal diameters is combo 13 The connector mentioned in clause 1 is characterized in that said collar is able to make a Luer lock with said dispensing instrument The connector mentioned in clause 1 is characterized in that said connector also contains at least one tubular air window in said connector where each air window also contains a first opening, a second opening and a conduit connected to said first opening to said second opening and said first opening is positioned in such a way that said containers are closed 10 with said hook, each of said first openings are located in said containers and each of said second openings are located externally in said connector in such a way that the positive air pressure is supplied to each of said containers reducing any vacuum force created inside said container during the extraction 15. connector cited in clause 1 is characterized in that each of said distal ends of said tubes have a pointed tip adapted to pierce the lid of said containers 20 16 The connector mentioned in clause 1 is characterized in that: a) said plurality of output ports consist of a first and second output ports; b) said plurality of input ports consist of a first and second input ports where said first input port is connected to said first output port and said second input port is connected to said second output port; c) said plurality of tubes consists of two tubes; Y d) said hook is adapted to simultaneously receive and close freely in the two containers in such a way that once the two containers are interspersed with said hook, said ends of said tubes allow the simultaneous and separate conduction of the liquids inside said instrument dispatcher 17. A device for driving liquids from a plurality of containers comprises: a) a plurality of containers where said containers are adapted to hold liquids; b) a dispensing instrument having at least two liquid receptacles for separately holding and dispensing in a controlled manner valuable liquids, said dispensing instrument further having a supply port connected to each liquid receptacle by a supply conduit, c) a connector for accommodating said dispensing instrument to said plurality of containers where said connector is characterized by: (i) a body having a bottom and a lid, said lid having an external perimeter and a plurality of external ports within said perimeter, said bottom having a plurality of input ports connected to said exit ports where each of said input ports are connected to one of said output ports by an internal diameter in said body, (ll) a collar extending from the perimeter, said collar adapted to separately receive said dispensing instrument connecting said supply ports to said input ports of said connector, (NI) a plurality of tubes wherein each of said tubes is connected to one of said inlet ports and has a distal end of said inlet ports to extend within one of said containers, each of said ends having an opening for drive the liquid, and (iv) a hook extending from said bottom and adapted to receive simultaneously sliding and closing freely in each plurality of containers in such a way that once said plurality of containers are interceding with said hook, said ends of said tubes allow simultaneously and separately driving the liquids within said liquid receptacles of said dispensing instrument 18. The equipment mentioned in clause 17 is characterized in that said collar, said body and said hook of said connector are formed of thermoplastic materials The equipment mentioned in clause 2 is characterized in that said thermoplastic of said connector is selected from a group consisting of polycarbonate, polystyrene, polypropylene, polytetrafluoroethylene, styrene-butadiene acplonitplo and acrylic The equipment mentioned in clause 17 is characterized in that it is characterized in that said collar, said body and said hook are formed by a single thermoplastic member 21 The equipment mentioned in clause 17 is characterized in that it is characterized in that said tubes are formed of a metallic matepal 22. The equipment mentioned in clause 17 is characterized in that it is characterized in that said collar fits in said dispensing instrument in such a way that said dispensing instrument can be accommodated in said connector in a single orientation. 23. The equipment mentioned in clause 17 is characterized in that it is characterized in that said hook contains a resistant material and is adjusted in such a way that when each of said containers are placed inside each said hook, said hook is formed resistently to accommodate and Secure each of these containers in place. 24. The equipment mentioned in clause 17 is characterized in that it is characterized in that said hook also contains a closing member adapted to secure said containers in said connector. 25. The equipment mentioned in clause 8 is characterized in that said closure member contains a resistant plastic attached to said hook and extends radially inward from said hook in such a way that when each of said containers is placed inside said closing member , said closure member secures each of said containers in place. 26 The equipment mentioned in clause 8 is characterized in that said closing member is ring-shaped inside said hook 27 The equipment mentioned in clause 17 is characterized in that each of said output ports has a circular shape 28 The equipment mentioned in clause 17 is characterized in that each of said internal diameters is combo 29 The equipment mentioned in clause 17 is characterized in that said collar is able to make a Luer lock with said dispensing instrument The equipment mentioned in clause 17 is characterized in that said connector also contains at least one tubular air window in said connector where each air window additionally contains a first opening, a second opening and a conduit connected to said opening aperture. said second opening and said opening aperture is positioned in such a way that said containers are closed with said hook, each of said ppm openings are located in said containers and each of said second openings are located externally in said connector in such a way that the positive air pressure is supplied to each of said containers reducing any vacuum force created inside said container during the extraction 30. The equipment mentioned in clause 17 is characterized in that each of said distal ends of said tubes of said connector has a pointed tip adapted to pierce the lid of said containers. 31. The equipment mentioned in clause 17 is characterized in that: a) said plurality of output ports consist of a first and second output ports; b) said plurality of input ports consist of a first and second input ports where said first input port is connected to said first output port and said second input port is connected to said second output port; c) said plurality of tubes consists of two tubes; Y d) said hook is adapted to simultaneously receive and close freely in the two containers in such a way that once the two containers are interspersed with said hook, said ends of said tubes allow the simultaneous and separate conduction of the liquids inside said instrument dispatcher 32 A device mentioned in clause 17 is characterized in that said connector comprises a) two output ports consisting of a ppmer and second output ports, b) two input ports consisting of a first and second input ports where said first input port is connected to said ppmer output port and said second input port is connected to said second output port, c) two tubes, and d) said hook is adapted to simultaneously receive and dine freely in the two containers and allow to simultaneously and separately conduct two liquids inside a dispensing instrument adapted to dispatch two liquids 33 A connector for connecting a dispensing instrument to multiple containers characterized by containing a) a body having a bottom and a lid, said lid has an external perimeter and a plurality of external ports within said meter, said bottom has a plurality of input ports connected to said output ports where each one of said input ports are connected to one of said output ports by an internal diameter in said body; b) a collar extending from the perimeter, said collar adapted to receive said dispensing instrument separately c) a plurality of tubes where each of said tubes is connected to one of said inlet ports and has a distal end of said inlet ports to extend within one of said containers, each of said ends having 10 an opening for conducting the liquid; d) a hook extending from said bottom; Y ?) a base having a plurality of support members adapted simultaneously to receive a plurality of containers, said base is adapted to receive said hook in such a way that once the hook is located in said base, said ends of said tubes they allow the simultaneous and separate conduction of liquids inside the dispensing instrument. 20 34. A connector for connecting a dispensing instrument to multiple containers characterized by containing: a) an envelope having a bottom and a lid, said lid has an external perimeter and a plurality of external ports within said perimeter, said envelope has a plurality of cavities each defining an internal volume for wrapping one of said containers, each one of these cavities has a port of entry 5 where each of the input ports is connected to each of the output ports by a conduit, b) a collar extending from the outer perimeter, said collar adapted to separately receive said dispensing instrument, c) a plurality of tubes where each of said tubes is connected to one of said input ports to extend within one of said containers, each of said ends has an opening for conducting the liquid, and D) a base having a plurality of support members adapted to receive simultaneously one of said containers, said base is adapted to freely receive said wrapping in such a way that said wrapping is located in said base, said containers are placed inside said cavities 20 35 A filling device to facilitate the conduction of a liquid inside a lepnga from a container the container must have a superior part where the liquid can enter and leave the container and a bottom that allows the container is supported straight on a flat surface, the filling device is characterized by containing a) a locator member of the container to place the container 5 b) a locator member of the syringe to align the syringe with the container to drive the liquid from the container Where, in the filling mode, the liquid conduit extends within the container to the syringe as a passage for the liquid from the container to the syringe and vice versa, also in the filling mode, the container locator member orients the container in an inclined position to increase the exit of liquid through the liquid conduit 15 36 A filling device according to clause 35 is characterized in that the container locator member inclines the container to align the lowest point of the container, in inclined position with the liquid conduit A filling device according to clause 35 is characterized in that the container has, in the inclined position, an inverted apex with the liquid conduit to facilitate the conduction of an optimum quantity of liquid from the container A filling device according to clause 35 is characterized in that the syringe locator member supports the syringe and moves down with the syringe towards the container and where the movement below the syringe locator member inclines the container locator member A filling device according to clause 35 is characterized in that the downstream movement of the syringe locator member towards the container locator member inserts the liquid conduit into the container A filling device according to clause 39 is characterized in that in the lid of the liquid container is closed by a seal, the liquid conduit has a downstream tip structure to penetrate the seal and where the downward movement of the member syringe locator to the container locator member penetrates the liquid conduit through container seal 41 A filling device according to clause 35 is characterized in that the filling device contains an eclipse for enclosing the container and the liquid conduit in the filling mode 42 A filling device according to clause 41 is characterized in that the filling provides a sealed ecubation allowing the device to filling, when assembled with the syringes and the container, is admitted in a sterile environment. 43. A filling device according to clause 35, 36, 37, 38, 39, 40, 41, 42 for a dual syringe applicator for liquid having dual syringe receptacles is characterized in that the syringe locator locates the two syringes in the syringe. In a side-by-side relationship, two liquid conduits are achieved to separately transport liquids from two containers to the dual syringe receptacles, the syringe locator member provides a side-by-side location of two liquid containers in alignment with the liquid conduits and where, in the filling mode, both containers are inclined to increase the liquid output of the containers. 44. A filling device to facilitate the transport inside a syringe of a liquid exiting a container, the container that has a tip through which the liquid can leave and enter the container and a bottom that allows the container to be supported in a straight manner On a flat surface, the filling device is characterized by containing: a) a container locator member to place the container; b) a syringe locator member for aligning the syringe with the container for liquid delivery from the container. Where, in the filling mode, a liquid conduit extends from the container to the syringe to pass the liquid from the container to the syringe and where the filling device further contains: c) a coating to encamp the container and the liquid conduit in the filling mode. 45. A filling device according to clause 44 is characterized in that the coating provides a sealed cover allowing the filling device, when assembled with the syringe and the container, to be admitted in a sterile medium. 15 46. A method for separately filling two liquids stored in two containers inside a dual syringe liquid applicator, each container having a neck through which liquid can pass from the container, a side wall extending downstream from the neck and a bottom that allows the container to be supported straight on a flat surface, the method is characterized in that 0 contains; a) locate the containers in a side-by-side relationship in a filling device having two separate liquid conduits, one for each liquid; b) connect the liquid applicator with the liquid conduits; and 5 c) operating the applicator to conduct the liquids simultaneously and separately from the containers through the liquid conduits in separate liquid receptacles in the dual syringe liquid applicator. 10 47. A method according to clause 46 is characterized in that each container has a circumference and where the liquid conduits extend laterally in the necks of the containers to accommodate the circumferences of the containers. 48. A method according to clause 46 is characterized by moving the dual syringe liquid applicator 15 and the liquid conduits down to insert the liquid conduits into the containers, before driving the liquids into the liquid applicator. 0