MX9710260A - 1,6-disubstituted isochromans for treatment of migraine headaches. - Google Patents

1,6-disubstituted isochromans for treatment of migraine headaches.

Info

Publication number
MX9710260A
MX9710260A MX9710260A MX9710260A MX9710260A MX 9710260 A MX9710260 A MX 9710260A MX 9710260 A MX9710260 A MX 9710260A MX 9710260 A MX9710260 A MX 9710260A MX 9710260 A MX9710260 A MX 9710260A
Authority
MX
Mexico
Prior art keywords
treatment
isochromans
disubstituted
migraine headaches
headaches
Prior art date
Application number
MX9710260A
Other languages
Spanish (es)
Inventor
Michael D Ennis
Ruth E Tenbrink
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of MX9710260A publication Critical patent/MX9710260A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

The present invention is 1,6-disubstituted isochromans of formula (I) and aromatic bicyclic amines (ABA) which are useful for the treatment of headaches, especially migraine and cluster headaches and also useful as antipsychotics and for the treatment of other CNS and/or cardiovascular disorders and as analgesics.
MX9710260A 1995-06-30 1996-06-07 1,6-disubstituted isochromans for treatment of migraine headaches. MX9710260A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74195P 1995-06-30 1995-06-30
US1123496P 1996-02-06 1996-02-06
PCT/US1996/008681 WO1997002259A1 (en) 1995-06-30 1996-06-07 1,6-disubstituted isochromans for treatment of migraine headaches

Publications (1)

Publication Number Publication Date
MX9710260A true MX9710260A (en) 1998-03-29

Family

ID=26668092

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9710260A MX9710260A (en) 1995-06-30 1996-06-07 1,6-disubstituted isochromans for treatment of migraine headaches.

Country Status (12)

Country Link
EP (1) EP0836599A1 (en)
JP (1) JPH11509532A (en)
AU (1) AU6252296A (en)
BR (1) BR9609631A (en)
CA (1) CA2225282A1 (en)
CZ (1) CZ418597A3 (en)
FI (1) FI974640A0 (en)
MX (1) MX9710260A (en)
NO (1) NO976112L (en)
PL (1) PL324319A1 (en)
SK (1) SK164297A3 (en)
WO (1) WO1997002259A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2370270A (en) * 2000-12-20 2002-06-26 Lilly Co Eli Pharmaceutical compounds
GB0130339D0 (en) * 2001-12-19 2002-02-06 Lilly Co Eli Isochroman compounds
US7335660B2 (en) 2001-12-19 2008-02-26 Eli Lilly And Company Isochroman compounds for treatment of CNS disorders
US7110576B2 (en) 2002-12-30 2006-09-19 Pitney Bowes Inc. System and method for authenticating a mailpiece sender
ATE458727T1 (en) 2004-05-05 2010-03-15 Hoffmann La Roche ARYLSULFONYLBENZODIOXANES SUITABLE FOR MODULATION OF THE 5-HT6 RECEPTOR, THE 5-HT2A RECEPTOR OR BOTH RECEPTORS
PL1831152T3 (en) 2004-12-21 2009-03-31 Hoffmann La Roche Tetralin and indane derivatives and uses thereof as 5-ht antagonists
SI1831159T1 (en) 2004-12-21 2010-04-30 Hoffmann La Roche Tetralin and indane derivatives and uses thereof
CN101119989B (en) 2004-12-21 2010-06-09 弗·哈夫曼-拉罗切有限公司 Chroman derivatives and uses thereof in treating CNS disease
CA2591793A1 (en) 2004-12-21 2006-06-29 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
ATE396183T1 (en) 2004-12-21 2008-06-15 Hoffmann La Roche CHROMEAND DERIVATIVES AND THEIR USE AS LIGANDS OF THE 5-HT RECEPTOR
WO2007051735A1 (en) 2005-11-03 2007-05-10 F. Hoffmann-La Roche Ag Arylsulfonylchromans as 5-ht6 inhibitors indolylmaleimide derivatives as protein kinase inhibitors
AU2007263084A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Tetralin and indane derivatives and uses thereof
AU2007263075A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonamidyl tetralin derivatives and uses thereof
AU2007263076A1 (en) 2006-06-20 2007-12-27 F. Hoffmann-La Roche Ag Arylsulfonyl naphthalene derivatives and uses thereof
JP2010229128A (en) * 2009-03-05 2010-10-14 Sumitomo Chemical Co Ltd Halogen-substituted terephthalic acid diamide compound, method for producing the same, and method for producing halogen-substituted benzene dimethanol by using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1552004A (en) * 1976-05-26 1979-09-05 Takeda Chemical Industries Ltd Isochroman derivatives
ATE182590T1 (en) * 1993-12-28 1999-08-15 Upjohn Co HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF CARDIOVASCULAR AND CENTRAL NERVOUS SYSTEM DISORDERS

Also Published As

Publication number Publication date
FI974640A (en) 1997-12-30
BR9609631A (en) 1999-03-02
CZ418597A3 (en) 1998-06-17
NO976112L (en) 1998-03-02
NO976112D0 (en) 1997-12-29
PL324319A1 (en) 1998-05-25
FI974640A0 (en) 1997-12-30
WO1997002259A1 (en) 1997-01-23
CA2225282A1 (en) 1997-01-23
SK164297A3 (en) 1998-09-09
JPH11509532A (en) 1999-08-24
EP0836599A1 (en) 1998-04-22
AU6252296A (en) 1997-02-05

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