MX9301942A - DERIVATIVES OF CYCLOHEXAN-ILIDENO NOVEDOSOS. - Google Patents

DERIVATIVES OF CYCLOHEXAN-ILIDENO NOVEDOSOS.

Info

Publication number
MX9301942A
MX9301942A MX9301942A MX9301942A MX9301942A MX 9301942 A MX9301942 A MX 9301942A MX 9301942 A MX9301942 A MX 9301942A MX 9301942 A MX9301942 A MX 9301942A MX 9301942 A MX9301942 A MX 9301942A
Authority
MX
Mexico
Prior art keywords
derivatives
useful
novedosos
ilideno
cyclohexan
Prior art date
Application number
MX9301942A
Other languages
Spanish (es)
Inventor
Siegfried Benjamin Christen Iv
Cornelia Jutta Forster
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MX9301942A publication Critical patent/MX9301942A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Se describen en la presente derivados ciclohexan-ilideno novedosos de la fórmula (I). Estos compuestos inhiben la producción de factor de necrosis tumoral y son útiles en el tratamiento de estados de enfermedad mediados o exacerbados por la producción de FNT; son útiles también en la mediación o inhibición de actividad enzimática o catalítica de fosfodieszterasa IV y por lo tanto son útiles en el tratamiento de estados de enfermedad que requieren mediación o inhibición de la misma.Novel cyclohexane-ylidene derivatives of formula (I) are described herein. These compounds inhibit the production of tumor necrosis factor and are useful in the treatment of disease states mediated or exacerbated by the production of TNF; they are also useful in the mediation or inhibition of enzymatic or catalytic activity of phosphodieszterase IV and therefore they are useful in the treatment of disease states that require mediation or inhibition thereof.

MX9301942A 1992-04-02 1993-03-05 DERIVATIVES OF CYCLOHEXAN-ILIDENO NOVEDOSOS. MX9301942A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86211192A 1992-04-02 1992-04-02
US96876192A 1992-10-30 1992-10-30
PCT/US1993/002516 WO1993019751A1 (en) 1992-04-02 1993-03-05 Compounds useful for treating inflammatory diseases and inhibiting production of tumor necrosis factor

Publications (1)

Publication Number Publication Date
MX9301942A true MX9301942A (en) 1994-08-31

Family

ID=27127668

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9301942A MX9301942A (en) 1992-04-02 1993-03-05 DERIVATIVES OF CYCLOHEXAN-ILIDENO NOVEDOSOS.

Country Status (10)

Country Link
US (1) US5605923A (en)
EP (1) EP0636026B1 (en)
JP (1) JP3251587B2 (en)
CN (1) CN1094031A (en)
AU (1) AU3924993A (en)
DE (1) DE69331265T2 (en)
IL (1) IL105220A0 (en)
MA (1) MA22922A1 (en)
MX (1) MX9301942A (en)
WO (1) WO1993019751A1 (en)

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DE69331265T2 (en) 2002-08-08
EP0636026A4 (en) 1995-02-22
EP0636026B1 (en) 2001-12-05
AU3924993A (en) 1993-11-08
EP0636026A1 (en) 1995-02-01
WO1993019751A1 (en) 1993-10-14
US5605923A (en) 1997-02-25
CN1094031A (en) 1994-10-26
JPH07508263A (en) 1995-09-14
DE69331265D1 (en) 2002-01-17
MA22922A1 (en) 1994-04-01
JP3251587B2 (en) 2002-01-28

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