MX2023001782A - Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms. - Google Patents

Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms.

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Publication number
MX2023001782A
MX2023001782A MX2023001782A MX2023001782A MX2023001782A MX 2023001782 A MX2023001782 A MX 2023001782A MX 2023001782 A MX2023001782 A MX 2023001782A MX 2023001782 A MX2023001782 A MX 2023001782A MX 2023001782 A MX2023001782 A MX 2023001782A
Authority
MX
Mexico
Prior art keywords
immunostimulatory bacteria
tumor
vaccines
therapeutics
colonization
Prior art date
Application number
MX2023001782A
Other languages
Spanish (es)
Inventor
Laura Hix Glickman
Christopher D Thanos
Alexandre Charles Michel Iannello
Haixing Kehoe
Bret Nicholas Peterson
Original Assignee
Actym Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US17/320,200 external-priority patent/US20220380720A1/en
Application filed by Actym Therapeutics Inc filed Critical Actym Therapeutics Inc
Publication of MX2023001782A publication Critical patent/MX2023001782A/en

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Abstract

Provided are attenuated immunostimulatory bacteria with genomes that are modified to, for example, reduce toxicity and improve the anti-tumor activity, such as by increasing accumulation in the tumor microenvironment, particularly in tumor- resident myeloid cells, improving resistance to complement inactivation, reducing immune cell death, promoting adaptive immunity, and enhancing T-cell function. Also provided are immunostimulatory bacteria for use as vaccines, and for delivery of mRNA. The increase in colonization of phagocytic cells improves the delivery of encoded therapeutic products to the tumor microenvironment and to tumors and permits, among other routes, systemic administration of the immunostimulatory bacteria. The increase in colonization of phagocytic cells also provides for use of immunostimulatory bacteria for direct tissue administration for use as vaccines.
MX2023001782A 2020-08-12 2021-08-12 Immunostimulatory bacteria-based vaccines, therapeutics, and rna delivery platforms. MX2023001782A (en)

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