MX2022009170A - Methods for treatment of cancer with an anti-tigit antagonist antibody. - Google Patents

Methods for treatment of cancer with an anti-tigit antagonist antibody.

Info

Publication number
MX2022009170A
MX2022009170A MX2022009170A MX2022009170A MX2022009170A MX 2022009170 A MX2022009170 A MX 2022009170A MX 2022009170 A MX2022009170 A MX 2022009170A MX 2022009170 A MX2022009170 A MX 2022009170A MX 2022009170 A MX2022009170 A MX 2022009170A
Authority
MX
Mexico
Prior art keywords
cancer
treatment
antagonist antibody
tigit antagonist
methods
Prior art date
Application number
MX2022009170A
Other languages
Spanish (es)
Inventor
Edward Namserk Cha
Yulei Wang
Stephen Chui
Raymond D Meng
Catherine Lai
Janet Lau
Anthony Jongha Lee
Shi Li
Yvonne Gail Lin-Liu
Christina Jeanne Matheny
Diana Mendus
Duc Anh Nguyen
Jilpa Bhupendra Patel
Thin Quang PHAM
Isabelle Anne Rooney
Heather Blythe Stevens
Sarah Marie Troutman
Lijia Wang
Patrick Georges Robert Williams
Benjamin Wu
Yibing Yan
Aijing Zhang
Xiaosong Zhang
Marcus Dale Ballinger
Hila Barak
Elizabeth Alexandra Bennett
Marcela Lucia Castro
Hui Min Phyllis Chan
Christopher Roland Cotter
Viraj Vinay Degaonkar
Barbara Jennifer Gitlitz
Tien Hoang
Kimberly Mayumi Komatsubara
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2020/024526 external-priority patent/WO2021194481A1/en
Priority claimed from PCT/US2020/049415 external-priority patent/WO2022050954A1/en
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX2022009170A publication Critical patent/MX2022009170A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention relates to methods, uses, and compositions for the treatment of cancer (e.g., a lung cancer; a cervical cancer; a breast cancer; a head and neck cancer; a liver cancer; a bladder cancer; a gastric cancer; an esophageal cancer; a pancreatic cancer; a kidney or renal cancer; a melanoma; an ovarian cancer; or a colorectal cancer). More specifically, the invention concerns the treatment of patients having cancer with an anti-TIGIT antagonist antibody, including treatment with an anti-TIGIT antagonist antibody in a combination therapy.
MX2022009170A 2020-01-27 2021-01-26 Methods for treatment of cancer with an anti-tigit antagonist antibody. MX2022009170A (en)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US202062966448P 2020-01-27 2020-01-27
US202062985822P 2020-03-05 2020-03-05
US202062994272P 2020-03-24 2020-03-24
PCT/US2020/024526 WO2021194481A1 (en) 2020-03-24 2020-03-24 Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
US202063059054P 2020-07-30 2020-07-30
US202063059960P 2020-07-31 2020-07-31
US202063074827P 2020-09-04 2020-09-04
US202063074807P 2020-09-04 2020-09-04
PCT/US2020/049415 WO2022050954A1 (en) 2020-09-04 2020-09-04 Dosing for treatment with anti-tigit and anti-pd-l1 antagonist antibodies
US202063085890P 2020-09-30 2020-09-30
US202063105198P 2020-10-23 2020-10-23
US202063114517P 2020-11-16 2020-11-16
US202063124693P 2020-12-11 2020-12-11
US202063127109P 2020-12-17 2020-12-17
PCT/US2021/015143 WO2021154761A1 (en) 2020-01-27 2021-01-26 Methods for treatment of cancer with an anti-tigit antagonist antibody

Publications (1)

Publication Number Publication Date
MX2022009170A true MX2022009170A (en) 2022-08-17

Family

ID=74626264

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022009170A MX2022009170A (en) 2020-01-27 2021-01-26 Methods for treatment of cancer with an anti-tigit antagonist antibody.

Country Status (10)

Country Link
EP (1) EP4096646A1 (en)
JP (1) JP2023511595A (en)
KR (1) KR20220133243A (en)
CN (1) CN115315256A (en)
AU (1) AU2021212662A1 (en)
CA (1) CA3165187A1 (en)
IL (1) IL294800A (en)
MX (1) MX2022009170A (en)
TW (1) TW202142230A (en)
WO (1) WO2021154761A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021293038A1 (en) * 2020-06-16 2023-02-02 F. Hoffmann-La Roche Ag Methods and compositions for treating triple-negative breast cancer
TW202309078A (en) * 2021-07-02 2023-03-01 美商建南德克公司 Methods and compositions for treating cancer
TW202320848A (en) * 2021-07-28 2023-06-01 美商建南德克公司 Methods and compositions for treating cancer
WO2023018675A1 (en) * 2021-08-10 2023-02-16 Merck Sharp & Dohme Llc A therapeutic combination comprising a tigit antagonist, a pd-1 antagonist, and lenvatinib
WO2023018677A1 (en) * 2021-08-10 2023-02-16 Merck Sharp & Dohme Llc A therapeutic combination comprising a t1git antagonist, a pd-1 antagonist, and a chemotherapeutic agent(s)
WO2023040804A1 (en) * 2021-09-14 2023-03-23 信达生物制药(苏州)有限公司 Pharmaceutical composition of anti-pd-1 antibody and chemotherapy agent and method for using same
TW202328195A (en) * 2021-09-15 2023-07-16 大陸商江蘇恆瑞醫藥股份有限公司 Proteins that specifically bind to pd-1 and the pharmaceutical use thereof
WO2023122665A1 (en) * 2021-12-22 2023-06-29 Genentech, Inc. Clinical formulations of anti-tigit antibodies
CN114181310B (en) * 2022-02-14 2022-07-05 中山康方生物医药有限公司 anti-TIGIT antibody, and pharmaceutical composition and use thereof

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548640B1 (en) 1986-03-27 2003-04-15 Btg International Limited Altered antibodies
DE3920358A1 (en) 1989-06-22 1991-01-17 Behringwerke Ag BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
CA2122732C (en) 1991-11-25 2008-04-08 Marc D. Whitlow Multivalent antigen-binding proteins
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
US5654307A (en) 1994-01-25 1997-08-05 Warner-Lambert Company Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
WO1996003397A1 (en) 1994-07-21 1996-02-08 Akzo Nobel N.V. Cyclic ketone peroxide formulations
US5804396A (en) 1994-10-12 1998-09-08 Sugen, Inc. Assay for agents active in proliferative disorders
JP3088018B2 (en) 1995-03-30 2000-09-18 ファイザー・インコーポレーテッド Quinazoline derivatives
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
GB9508565D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quiazoline derivative
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
CZ1598A3 (en) 1995-07-06 1998-04-15 Novartis Ag Pyrrolopyrimidines and process for preparing thereof
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
CN100503580C (en) 1996-04-12 2009-06-24 沃尼尔·朗伯公司 Irreversible inhibitor of tyrosine kinase
DK0912559T3 (en) 1996-07-13 2003-03-10 Glaxo Group Ltd Condensed heterocyclic compounds as protein tyrosine kinase inhibitors
ID18494A (en) 1996-10-02 1998-04-16 Novartis Ag PIRAZOLA DISTRIBUTION IN THE SEQUENCE AND THE PROCESS OF MAKING IT
UA73073C2 (en) 1997-04-03 2005-06-15 Уайт Холдінгз Корпорейшн Substituted 3-cyan chinolines
US6002008A (en) 1997-04-03 1999-12-14 American Cyanamid Company Substituted 3-cyano quinolines
ES2201484T3 (en) 1997-05-06 2004-03-16 Wyeth Holdings Corporation USE OF QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF RENAL POLYCHYSTOSIS DISEASE.
ZA986729B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitors of tyrosine kinases
ZA986732B (en) 1997-07-29 1999-02-02 Warner Lambert Co Irreversible inhibitiors of tyrosine kinases
TW436485B (en) 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
BR9814116A (en) 1997-11-06 2000-10-03 American Cyanamid Co Use of quinazoline derivatives as tyrosine kinase inhibitors for the treatment of colonic polyp
WO1999029888A1 (en) 1997-12-05 1999-06-17 The Scripps Research Institute Humanization of murine antibody
ATE229008T1 (en) 1998-11-19 2002-12-15 Warner Lambert Co N- 4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-7-(3- MORFOLIN-4-YL-PROPOXY)-CHINAZOLINE-6-YL -AKRYLAMIDE, AN IRREVERSIBLE TYROSINE KINASE INHIBITOR
EP3042964A1 (en) 2004-06-04 2016-07-13 Genentech, Inc. Egfr mutations
ES2633864T3 (en) 2012-09-24 2017-09-25 Ventana Medical Systems, Inc. Procedure to identify non-small cell lung cancer that responds to treatment using anaplastic lymphoma kinase (alk) as a marker
LT3294770T (en) 2015-05-12 2020-12-28 F. Hoffmann-La Roche Ag Therapeutic and diagnostic methods for cancer
CA2984003A1 (en) 2015-05-29 2016-12-08 Genentech, Inc. Therapeutic and diagnostic methods for cancer
KR20200135313A (en) * 2018-02-26 2020-12-02 제넨테크, 인크. Dosing for treatment with anti-TIGIT and anti-PD-L1 antagonist antibodies

Also Published As

Publication number Publication date
KR20220133243A (en) 2022-10-04
CA3165187A1 (en) 2021-08-05
TW202142230A (en) 2021-11-16
IL294800A (en) 2022-09-01
JP2023511595A (en) 2023-03-20
EP4096646A1 (en) 2022-12-07
CN115315256A (en) 2022-11-08
AU2021212662A1 (en) 2022-08-11
WO2021154761A1 (en) 2021-08-05

Similar Documents

Publication Publication Date Title
MX2022009170A (en) Methods for treatment of cancer with an anti-tigit antagonist antibody.
CY1120300T1 (en) CLAUDIN 6 SPECIALTY PARTS (CLDN6)
CY1117031T1 (en) CLAUDIN-18 Monoclonal Antibodies In Cancer Treatment
ZA202110422B (en) Heterocyclic compounds, preparation methods and uses thereof
MX2020012204A (en) Kras g12c inhibitors for treating cancer.
MX2019009967A (en) Bispecific binding molecules that are capable of binding cd137 and tumor antigens, and uses thereof.
JOP20170131B1 (en) 1-trahydropyranylcarbonyl-2,3-dihydro-1h-indole compounds for treating cancer
CA3156451A1 (en) Antibodies having specificity for nectin-4 and uses thereof
TW200610538A (en) Therapy of platinum-resistant cancer
MY152864A (en) Treatment of metastatic breast cancer
MX2020001224A (en) Antibodies for treatment of cancer expressing claudin 6.
NZ607337A (en) Antibodies for epidermal growth factor receptor 3 (her3)
EA024630B9 (en) Pyrazole derivatives as calcium release-activated calcium (crac) channel inhibitors
NZ628298A (en) Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
RU2014108044A (en) PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF A MALIGNANT TUMOR
WO2021007428A3 (en) Molecules, compositions and methods for treatment of cancer
MX2009009816A (en) Monoclonal antibodies for treatment of cancer.
ZA201907225B (en) Treatment of her2 positive cancers
RU2017138468A (en) ANTIBODIES AGAINST HUMAN HER3, HAVING LOW CONTENT OF FUKOZY, AND AREAS OF THEIR APPLICATION
PE20221830A1 (en) SPECIFIC ANTIBODIES AGAINST CLAUDIN 18.2 TUMOR
RU2016112421A (en) ANTI-TUMORING AGENT AND AMPLIFIER OF ANTI-TUMOR EFFECT
MX2021005784A (en) Compounds that selectively and effectively inhibit hakai-mediated ubiquitination, as anti-cancer drugs.
MX2021012644A (en) Integrin alpha10 and aggressive cancer forms.
MY188446A (en) Treatment of patients diagnosed with pancreatic ductal adenocarcinoma using monoclonal antibodies against the epidermal growth factor receptor (egfr)
BG108932A (en) Pharmaceutical composition comprising arsenite for the treatment of malignancy