MX2018015770A - Variant adeno-associated viruses and methods of using. - Google Patents

Variant adeno-associated viruses and methods of using.

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Publication number
MX2018015770A
MX2018015770A MX2018015770A MX2018015770A MX2018015770A MX 2018015770 A MX2018015770 A MX 2018015770A MX 2018015770 A MX2018015770 A MX 2018015770A MX 2018015770 A MX2018015770 A MX 2018015770A MX 2018015770 A MX2018015770 A MX 2018015770A
Authority
MX
Mexico
Prior art keywords
methods
associated viruses
variant adeno
adeno
variant
Prior art date
Application number
MX2018015770A
Other languages
Spanish (es)
Inventor
Schaffer David
Dudman Joshua
Hantman Adam
Looger Loren
Ritola Kimberly
Gowanlock Robinson Tervo Dougal
Viswanathan Sarada
Karpova Alla
Hwang Bum-Yeol
Original Assignee
Hughes Howard Med Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hughes Howard Med Inst filed Critical Hughes Howard Med Inst
Publication of MX2018015770A publication Critical patent/MX2018015770A/en

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    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/015—Parvoviridae, e.g. feline panleukopenia virus, human parvovirus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C40—COMBINATORIAL TECHNOLOGY
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    • C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
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    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
    • C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biochemistry (AREA)
  • Virology (AREA)
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  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Ophthalmology & Optometry (AREA)
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Abstract

The present disclosure provides AAV variants that exhibit a preference for retrograde movement in neurons and methods of using such variants.
MX2018015770A 2016-06-15 2017-06-15 Variant adeno-associated viruses and methods of using. MX2018015770A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662350361P 2016-06-15 2016-06-15
US201662404585P 2016-10-05 2016-10-05
PCT/US2017/037781 WO2017218842A1 (en) 2016-06-15 2017-06-15 Variant adeno-associated viruses and methods of using

Publications (1)

Publication Number Publication Date
MX2018015770A true MX2018015770A (en) 2019-08-29

Family

ID=59258370

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015770A MX2018015770A (en) 2016-06-15 2017-06-15 Variant adeno-associated viruses and methods of using.

Country Status (27)

Country Link
US (2) US10961282B2 (en)
EP (2) EP4268852A3 (en)
JP (2) JP7094277B2 (en)
KR (2) KR102522661B1 (en)
CN (2) CN116003532A (en)
AU (2) AU2017286652B2 (en)
BR (1) BR112018076090A2 (en)
CA (1) CA3028113A1 (en)
DK (1) DK3472183T3 (en)
EA (1) EA201990033A1 (en)
ES (1) ES2962611T3 (en)
FI (1) FI3472183T3 (en)
HR (1) HRP20231403T1 (en)
HU (1) HUE063755T2 (en)
IL (2) IL300981A (en)
LT (1) LT3472183T (en)
MA (1) MA44546B1 (en)
MX (1) MX2018015770A (en)
MY (1) MY190221A (en)
PH (1) PH12018502664A1 (en)
PL (1) PL3472183T3 (en)
PT (1) PT3472183T (en)
RS (1) RS64769B1 (en)
SG (1) SG11201811189RA (en)
SI (1) SI3472183T1 (en)
WO (1) WO2017218842A1 (en)
ZA (1) ZA201900278B (en)

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EP3827812A1 (en) * 2016-07-29 2021-06-02 The Regents of the University of California Adeno-associated virus virions with variant capsid and methods of use thereof
MX2020001997A (en) 2017-08-28 2020-07-20 Univ California Adeno-associated virus capsid variants and methods of use thereof.
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MX2021001336A (en) * 2018-07-31 2021-09-10 Univ Cornell Gene therapy methods to control organ function.
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CN111825772B (en) * 2020-07-30 2023-10-20 中国科学院精密测量科学与技术创新研究院 Adeno-associated virus with variant capsid protein and application thereof
MX2023000968A (en) 2020-08-06 2023-03-01 Fundacion Para La Investig Medica Aplicada Viral particles for use in treating tauopathies such as alzheimer's diseases by gene therapy.
WO2022126189A1 (en) * 2020-12-16 2022-06-23 Children's Medical Research Institute Adeno-associated virus capsids and vectors
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WO2023288184A2 (en) * 2021-07-14 2023-01-19 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for treating chronic pain and for retrograde transduction of neurons
KR20240052746A (en) 2021-07-14 2024-04-23 메이라지티엑스 유케이 Ii 리미티드 KCNV2 gene therapy
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WO2023131811A2 (en) 2021-12-15 2023-07-13 Meiragtx Uk Ii Limited Polycistronic expression of gut peptides
WO2023192450A1 (en) * 2022-03-30 2023-10-05 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Adeno-associated virus vectors for nucleic acid delivery to retinal ganglion cells and/or retinal pigment epithelium cells
WO2024056902A2 (en) 2022-09-16 2024-03-21 Christopher Shaw Compositions and methods for treating neurological diseases
WO2024079657A1 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Formulations for aav gene therapy
WO2024079655A1 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Chromatography methods for purification of aav capsids
WO2024079662A1 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Upf1 expression constructs
WO2024079530A2 (en) 2022-10-11 2024-04-18 Meiragtx Uk Ii Limited Nucleic acid regulatory elements for gene expression in the muscle and methods of use
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AU2021225247B2 (en) 2023-02-16
BR112018076090A2 (en) 2019-03-26
WO2017218842A1 (en) 2017-12-21
AU2017286652A1 (en) 2019-01-24
HRP20231403T1 (en) 2024-02-16
HUE063755T2 (en) 2024-01-28
US20210230231A1 (en) 2021-07-29
SI3472183T1 (en) 2023-11-30
KR20190039930A (en) 2019-04-16
ES2962611T3 (en) 2024-03-20
IL263719B2 (en) 2023-09-01
CN109641939A (en) 2019-04-16
PL3472183T3 (en) 2024-02-12
MY190221A (en) 2022-04-06
US20190300579A1 (en) 2019-10-03
FI3472183T3 (en) 2023-11-03
CN116003532A (en) 2023-04-25
PH12018502664A1 (en) 2019-10-07
AU2021225247A1 (en) 2021-09-30
EP3472183A1 (en) 2019-04-24
CN109641939B (en) 2022-11-08
US10961282B2 (en) 2021-03-30
IL263719A (en) 2019-01-31
US11939355B2 (en) 2024-03-26
ZA201900278B (en) 2022-04-28
EP4268852A3 (en) 2024-02-07
CA3028113A1 (en) 2017-12-21
RS64769B1 (en) 2023-11-30
EA201990033A1 (en) 2019-06-28
JP2019518793A (en) 2019-07-04
AU2017286652B2 (en) 2021-10-07
IL263719B1 (en) 2023-05-01
IL300981A (en) 2023-04-01
EP4268852A2 (en) 2023-11-01
JP7094277B2 (en) 2022-07-01
DK3472183T3 (en) 2023-11-06
PT3472183T (en) 2023-11-16
KR102522661B1 (en) 2023-04-18
LT3472183T (en) 2023-09-25
MA44546A1 (en) 2019-07-31
SG11201811189RA (en) 2019-01-30
MA44546B1 (en) 2021-03-31
EP3472183B1 (en) 2023-08-09
KR20230054754A (en) 2023-04-25

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