MX2018007145A - Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use. - Google Patents
Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use.Info
- Publication number
- MX2018007145A MX2018007145A MX2018007145A MX2018007145A MX2018007145A MX 2018007145 A MX2018007145 A MX 2018007145A MX 2018007145 A MX2018007145 A MX 2018007145A MX 2018007145 A MX2018007145 A MX 2018007145A MX 2018007145 A MX2018007145 A MX 2018007145A
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- myostatin antibodies
- regions
- polypeptides containing
- nucleic acids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/53—Hinge
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The disclosure provides anti-myostatin antibodies and methods of making and using the same. Nucleic acids encoding the anti-myostatin antibodies and host cells comprising the nucleic acids are also provided. The disclosure also provides polypeptides containing a variant Fc region and methods of making and using the same. Nucleic acids encoding the polypeptides and host cells comprising the nucleic acids are also provided.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2015247070 | 2015-12-18 | ||
PCT/JP2016/087487 WO2017104783A1 (en) | 2015-12-18 | 2016-12-16 | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018007145A true MX2018007145A (en) | 2018-08-15 |
Family
ID=59011957
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018007145A MX2018007145A (en) | 2015-12-18 | 2016-12-16 | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use. |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP3390443A4 (en) |
JP (4) | JP6142069B1 (en) |
KR (4) | KR20240058997A (en) |
CN (2) | CN108473562B (en) |
AR (1) | AR107078A1 (en) |
AU (1) | AU2016372934B2 (en) |
BR (1) | BR112018011073A2 (en) |
CA (1) | CA3002422C (en) |
EA (1) | EA201891420A1 (en) |
HK (1) | HK1254755A1 (en) |
MX (1) | MX2018007145A (en) |
MY (1) | MY189425A (en) |
PH (1) | PH12018501280A1 (en) |
SG (2) | SG11201610812WA (en) |
TW (3) | TWI605057B (en) |
WO (1) | WO2017104783A1 (en) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5624276B2 (en) | 2006-03-31 | 2014-11-12 | 中外製薬株式会社 | Methods for controlling blood kinetics of antibodies |
EP4368721A2 (en) | 2007-09-26 | 2024-05-15 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
MY195714A (en) | 2008-04-11 | 2023-02-07 | Chugai Pharmaceutical Co Ltd | Antigen-Binding Molecule Capable of Binding to Two or More Antigen Molecules Repeatedly |
KR102385507B1 (en) | 2010-11-30 | 2022-04-12 | 추가이 세이야쿠 가부시키가이샤 | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
TWI766939B (en) | 2012-05-30 | 2022-06-11 | 日商中外製藥股份有限公司 | target tissue-specific antigen binding molecule |
WO2014030750A1 (en) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | MOUSE FcγRII-SPECIFIC Fc ANTIBODY |
KR102273985B1 (en) | 2012-08-24 | 2021-07-06 | 추가이 세이야쿠 가부시키가이샤 | FcγRIIb-specific Fc region variant |
CN113621057A (en) | 2013-04-02 | 2021-11-09 | 中外制药株式会社 | Fc region variants |
TW202043467A (en) | 2013-12-04 | 2020-12-01 | 日商中外製藥股份有限公司 | Antigen-binding molecules, the antigen-binding activity of which varies according to the concentration of compounds, and libraries of said molecules |
MA41294A (en) | 2014-12-19 | 2017-11-08 | Chugai Pharmaceutical Co Ltd | ANTI-MYOSTATIN ANTIBODIES, POLYPEPTIDES CONTAINING FC REGION VARIANTS, AND METHODS OF USE |
EP3253778A1 (en) | 2015-02-05 | 2017-12-13 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
EA201891420A1 (en) * | 2015-12-18 | 2019-02-28 | Чугаи Сейяку Кабусики Кайся | ANTIBODIES TO MYOSTATIN, POLYPEPTIDES, CONTAINING OPTIONS OF FC-REGIONS, AND METHODS OF THEIR APPLICATION |
WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
KR20220143961A (en) * | 2016-06-17 | 2022-10-25 | 추가이 세이야쿠 가부시키가이샤 | Anti-myostatin antibodies and methods of use |
AU2017305073B2 (en) | 2016-08-05 | 2024-02-01 | Chugai Seiyaku Kabushiki Kaisha | Composition for prevention or treatment of IL-8 related diseases |
SG11201907288RA (en) | 2017-02-28 | 2019-09-27 | Seattle Genetics Inc | Cysteine mutated antibodies for conjugation |
CA3108369A1 (en) | 2018-08-10 | 2020-02-13 | Tomoyuki Igawa | Anti-cd137 antigen-binding molecule and utilization thereof |
CA3136398A1 (en) * | 2019-04-10 | 2020-10-15 | Chugai Seiyaku Kabushiki Kaisha | Method for purifying fc region-modified antibody |
KR20220093103A (en) * | 2019-09-13 | 2022-07-05 | 어드메어 테라퓨틱스 소사이어티 | Anti-oncolytic virus antigen antibody and method of use thereof |
RU2750267C1 (en) * | 2020-02-07 | 2021-06-25 | Общество с ограниченной ответственностью «НАУЧНО-ПРОИЗВОДСТВЕННОЕ ОБЪЕДИНЕНИЕ ИН-ВЕТ» | Recombinant growth differentiation factor 11 (gdf11), a method for its production, an injectable drug for increasing the muscle mass of mammals and poultry as well as a method of using the drug |
TW202144395A (en) | 2020-02-12 | 2021-12-01 | 日商中外製藥股份有限公司 | Anti-CD137 antigen-binding molecule for use in cancer treatment |
CN118055767A (en) | 2021-10-06 | 2024-05-17 | 豪夫迈·罗氏有限公司 | Novel combined application |
WO2023187022A1 (en) | 2022-04-01 | 2023-10-05 | F. Hoffmann-La Roche Ag | New treatment for facioscapulohumeral muscular dystrophy (fshd) |
US11780910B1 (en) | 2022-05-02 | 2023-10-10 | Novo Nordisk A/S | Anti-ANGPTL3 antibodies suitable for high concentration compositions and subcutaneous administration |
US20240173325A1 (en) | 2022-10-14 | 2024-05-30 | Genentech, Inc. | Methods for treating spinal muscular atrophy |
CN116990528B (en) * | 2023-09-27 | 2024-02-06 | 成都华西海圻医药科技有限公司 | Analysis method for rapidly determining anti-CD40 monoclonal antibody based on Gyrolab platform |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7320789B2 (en) * | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
AR047392A1 (en) * | 2002-10-22 | 2006-01-18 | Wyeth Corp | NEUTRALIZATION OF ANTIBODIES AGAINST GDF 8 AND ITS USE FOR SUCH PURPOSES |
JP5017116B2 (en) * | 2004-09-24 | 2012-09-05 | アムジエン・インコーポレーテツド | Modified Fc molecule |
US8008453B2 (en) * | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
CA2661836A1 (en) * | 2006-09-05 | 2008-03-13 | Eli Lilly And Company | Anti-myostatin antibodies |
PE20091163A1 (en) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | ANTIBODIES FOR GDF8 |
MY195714A (en) * | 2008-04-11 | 2023-02-07 | Chugai Pharmaceutical Co Ltd | Antigen-Binding Molecule Capable of Binding to Two or More Antigen Molecules Repeatedly |
UY32341A (en) * | 2008-12-19 | 2010-07-30 | Glaxo Group Ltd | NEW ANTIGEN UNION PROTEINS |
SG10201507722QA (en) * | 2010-03-11 | 2015-10-29 | Rinat Neuroscience Corp | ANTIBODIES WITH pH DEPENDENT ANTIGEN BINDING |
TW201210612A (en) * | 2010-06-03 | 2012-03-16 | Glaxo Group Ltd | Humanised antigen binding proteins |
HUE053310T2 (en) * | 2012-03-16 | 2021-06-28 | Regeneron Pharma | Histidine engineered light chain antibodies and genetically modified rodents for generating the same |
TWI619729B (en) * | 2012-04-02 | 2018-04-01 | 再生元醫藥公司 | Anti-hla-b*27 antibodies and uses thereof |
WO2014028354A1 (en) * | 2012-08-13 | 2014-02-20 | Regeneron Pharmaceuticals, Inc. | Anti-pcsk9 antibodies with ph-dependent binding characteristics |
KR102273985B1 (en) * | 2012-08-24 | 2021-07-06 | 추가이 세이야쿠 가부시키가이샤 | FcγRIIb-specific Fc region variant |
SG10201800800YA (en) * | 2013-05-06 | 2018-03-28 | Scholar Rock Inc | Compositions and methods for growth factor modulation |
AU2014307589A1 (en) * | 2013-08-14 | 2016-02-11 | Novartis Ag | Methods of treating sporadic inclusion body myositis |
AU2015342936B2 (en) * | 2014-11-06 | 2020-10-08 | Scholar Rock, Inc. | Anti-pro/latent-Myostatin antibodies and uses thereof |
WO2016073879A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related antibodies and uses thereof |
MA41294A (en) * | 2014-12-19 | 2017-11-08 | Chugai Pharmaceutical Co Ltd | ANTI-MYOSTATIN ANTIBODIES, POLYPEPTIDES CONTAINING FC REGION VARIANTS, AND METHODS OF USE |
EA201891420A1 (en) * | 2015-12-18 | 2019-02-28 | Чугаи Сейяку Кабусики Кайся | ANTIBODIES TO MYOSTATIN, POLYPEPTIDES, CONTAINING OPTIONS OF FC-REGIONS, AND METHODS OF THEIR APPLICATION |
-
2016
- 2016-12-16 EA EA201891420A patent/EA201891420A1/en unknown
- 2016-12-16 MX MX2018007145A patent/MX2018007145A/en unknown
- 2016-12-16 JP JP2016244254A patent/JP6142069B1/en active Active
- 2016-12-16 AU AU2016372934A patent/AU2016372934B2/en active Active
- 2016-12-16 KR KR1020247013912A patent/KR20240058997A/en active Search and Examination
- 2016-12-16 AR ARP160103887A patent/AR107078A1/en unknown
- 2016-12-16 WO PCT/JP2016/087487 patent/WO2017104783A1/en active Application Filing
- 2016-12-16 EP EP16875757.3A patent/EP3390443A4/en active Pending
- 2016-12-16 SG SG11201610812WA patent/SG11201610812WA/en unknown
- 2016-12-16 CN CN201680072782.7A patent/CN108473562B/en active Active
- 2016-12-16 KR KR1020187001235A patent/KR102501335B1/en active IP Right Grant
- 2016-12-16 KR KR1020237005092A patent/KR20230027321A/en not_active IP Right Cessation
- 2016-12-16 TW TW105141729A patent/TWI605057B/en active
- 2016-12-16 CA CA3002422A patent/CA3002422C/en active Active
- 2016-12-16 TW TW106129765A patent/TWI749057B/en active
- 2016-12-16 TW TW110149330A patent/TW202231662A/en unknown
- 2016-12-16 SG SG10201707267RA patent/SG10201707267RA/en unknown
- 2016-12-16 MY MYPI2018702306A patent/MY189425A/en unknown
- 2016-12-16 CN CN202210678733.5A patent/CN115028721A/en active Pending
- 2016-12-16 BR BR112018011073A patent/BR112018011073A2/en active Search and Examination
- 2016-12-16 KR KR1020177003241A patent/KR101820637B1/en active IP Right Grant
-
2017
- 2017-05-08 JP JP2017092151A patent/JP7053164B2/en active Active
-
2018
- 2018-06-14 PH PH12018501280A patent/PH12018501280A1/en unknown
- 2018-10-29 HK HK18113798.7A patent/HK1254755A1/en unknown
-
2022
- 2022-03-31 JP JP2022058710A patent/JP2022097485A/en active Pending
-
2023
- 2023-11-29 JP JP2023201204A patent/JP2024023427A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PH12018501280A1 (en) | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use | |
MX2023001834A (en) | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use. | |
MX2023007211A (en) | Anti-myostatin antibodies and methods of use. | |
MX2022001222A (en) | Anti-tim-3 antibodies and methods of use thereof. | |
MX2023008559A (en) | Il15/il15rî± heterodimeric fc-fusion proteins. | |
SG10201909716RA (en) | Modified j-chain | |
MX2017014397A (en) | Anti-fcrn antibodies. | |
SG10201909180SA (en) | Humanized anti-c1s antibodies and methods of use thereof | |
PH12016501689B1 (en) | Tatk-cdkl5 fusion proteins, compositions, formulations, and use thereof | |
MX2019013124A (en) | Uti fusion proteins. | |
PH12020550483A1 (en) | Anti-apoc3 antibodies and methods of use thereof | |
MX2015012281A (en) | Improved tnf binding proteins. | |
MX2018003445A (en) | Expression of fc-containing proteins. |