MX2011009806A - Nuevos derivados de indazol inhibidores de hsp90, composiciones que los contienen y su uso. - Google Patents
Nuevos derivados de indazol inhibidores de hsp90, composiciones que los contienen y su uso.Info
- Publication number
- MX2011009806A MX2011009806A MX2011009806A MX2011009806A MX2011009806A MX 2011009806 A MX2011009806 A MX 2011009806A MX 2011009806 A MX2011009806 A MX 2011009806A MX 2011009806 A MX2011009806 A MX 2011009806A MX 2011009806 A MX2011009806 A MX 2011009806A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- optionally substituted
- compositions containing
- containing same
- indazole derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La invención se refiere a nuevos productos que tienen fórmula (I), en donde; R4 representa H, CH3, CH2CH3, CF3, F, CI, Br, I; Het representa un heterociclo sustituido opcionalmente por uno o más radicales R1 ó Rl seleccionados entre H, halógeno, CF3, nitro, ciano, alquilo, hidroxi, mercapto, amino, alquilamino, dialquilamino, alcoxi, fenilalcoxi, alquiltio, carboxi libre o esterificado con un radical alquilo, carboxamida, CO-NH(alquilo), CON(alquilo)2, NH-CO-alquilo, sulfonamida, NH-SO2-alquilo, S(O)2-N Halquilo, S(O2)-N(alquilo)2, todos los radicales alquilo, alcoxi y alquiltio están a su vez sustituidos opcionalmente; R se selecciona del grupo que comprende (A'), (B), (C), (D) y (E), en donde W1, W2, W3 representan independientemente CH ó N, X representa: O, S, NR2, C(O), S(O) ó S(O)2; V representa H, Hal, -O-R2 ó -NH-R2, con R2 representa H, alquilo, cicloalquilo o heterocicloalquilo sustituidos opcionalmente; estando estos productos en todas las formas isómeras y las sales, como medicamentos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0901274A FR2943341B1 (fr) | 2009-03-19 | 2009-03-19 | Nouveaux derives d'indazole inhibiteurs d'hsp90,compositions les contenant et utilisation |
| FR1050341A FR2955323B1 (fr) | 2010-01-19 | 2010-01-19 | Nouveaux derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
| PCT/FR2010/050483 WO2010106290A1 (fr) | 2009-03-19 | 2010-03-18 | Derives d'indazole inhibiteurs d'hsp90, compositions les contenant et utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011009806A true MX2011009806A (es) | 2011-09-29 |
Family
ID=42313103
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011009806A MX2011009806A (es) | 2009-03-19 | 2010-03-18 | Nuevos derivados de indazol inhibidores de hsp90, composiciones que los contienen y su uso. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20120010241A1 (es) |
| EP (1) | EP2408762A1 (es) |
| JP (1) | JP2012520859A (es) |
| KR (1) | KR20110128942A (es) |
| CN (1) | CN102439003A (es) |
| AR (1) | AR075874A1 (es) |
| AU (1) | AU2010224652A1 (es) |
| BR (1) | BRPI1009375A2 (es) |
| CA (1) | CA2755660A1 (es) |
| IL (1) | IL215139A0 (es) |
| MX (1) | MX2011009806A (es) |
| RU (1) | RU2011142151A (es) |
| SG (1) | SG174466A1 (es) |
| TW (1) | TW201038553A (es) |
| UY (1) | UY32505A (es) |
| WO (1) | WO2010106290A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI1013999B1 (pt) | 2009-07-10 | 2020-06-02 | Taiho Pharmaceutical Co., Ltd. | Composto de azabiciclo e um sal deste, produto farmacêutico e composição farmacêutica compreendendo dito composto e uso do mesmo para tratar câncer |
| BR112013017416A2 (pt) * | 2011-01-07 | 2019-09-24 | Taiho Pharmaceutical Co Ltd | derivado de indola ou indazola ou sal do mesmo |
| CN103313970B (zh) * | 2011-01-07 | 2016-09-07 | 大鹏药品工业株式会社 | 新型二环式化合物或其盐 |
| EP2831061A1 (en) * | 2012-03-28 | 2015-02-04 | Synta Pharmaceuticals Corp. | Triazole derivatives as hsp90 inhibitors |
| CN104302625B (zh) * | 2012-05-18 | 2017-04-19 | 赛诺菲 | 吡唑衍生物及其作为lpar5拮抗剂的用途 |
| US9096549B2 (en) * | 2013-02-01 | 2015-08-04 | Acetylon Pharmaceuticals, Inc. | Selective HDAC3 inhibitors |
| DE102017008073A1 (de) * | 2017-08-28 | 2019-02-28 | Henkel Ag & Co. Kgaa | Neue anionische Tenside und Wasch- und Reinigungsmittel, welche diese enthalten |
| CN117003754A (zh) * | 2022-04-28 | 2023-11-07 | 腾讯科技（深圳）有限公司 | 吡咯并[2,3-d]嘧啶或吡唑并[3,4-d]嘧啶衍生物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6353007B1 (en) * | 2000-07-13 | 2002-03-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 1-(4-aminophenyl)indoles and their use as anti-inflammatory agents |
| WO2003027107A1 (en) * | 2001-09-26 | 2003-04-03 | Bayer Pharmaceuticals Corporation | Substituted 3-pyridyl oxazoles as c17,20 lyase inhibitors |
| US7297709B2 (en) * | 2003-05-22 | 2007-11-20 | Abbott Laboratories | Indazole, benzisoxazole, and benzisothiazole kinase inhibitors |
| ES2527770T3 (es) * | 2005-02-25 | 2015-01-29 | Serenex, Inc. | Derivados de tetrahidroindolona y tetrahidroindazolona |
| JP2007145786A (ja) * | 2005-11-30 | 2007-06-14 | Toray Ind Inc | ピラジン誘導体及びそれを有効成分とする腎炎治療薬 |
| JP2009527562A (ja) * | 2006-02-21 | 2009-07-30 | アムゲン インコーポレイティッド | ホスホジエステラーゼ１０阻害剤としてのシンノリン誘導体 |
| US20090170898A1 (en) * | 2006-03-31 | 2009-07-02 | Malena Bengtsson | Sulphonamide Derivatives as Modulators of the Glucocorticoid Receptor |
| JP2010501593A (ja) * | 2006-08-24 | 2010-01-21 | セレネックス， インコーポレイテッド | イソキノリン、キナゾリンおよびフタラジン誘導体 |
-
2010
- 2010-03-18 AR ARP100100858A patent/AR075874A1/es not_active Application Discontinuation
- 2010-03-18 CN CN2010800219733A patent/CN102439003A/zh active Pending
- 2010-03-18 TW TW099108049A patent/TW201038553A/zh unknown
- 2010-03-18 US US13/257,516 patent/US20120010241A1/en not_active Abandoned
- 2010-03-18 SG SG2011067634A patent/SG174466A1/en unknown
- 2010-03-18 WO PCT/FR2010/050483 patent/WO2010106290A1/fr active Application Filing
- 2010-03-18 BR BRPI1009375A patent/BRPI1009375A2/pt not_active IP Right Cessation
- 2010-03-18 AU AU2010224652A patent/AU2010224652A1/en not_active Abandoned
- 2010-03-18 CA CA2755660A patent/CA2755660A1/fr not_active Abandoned
- 2010-03-18 MX MX2011009806A patent/MX2011009806A/es not_active Application Discontinuation
- 2010-03-18 JP JP2012500297A patent/JP2012520859A/ja active Pending
- 2010-03-18 RU RU2011142151/04A patent/RU2011142151A/ru not_active Application Discontinuation
- 2010-03-18 EP EP10715951A patent/EP2408762A1/fr not_active Withdrawn
- 2010-03-18 KR KR1020117024518A patent/KR20110128942A/ko not_active Application Discontinuation
- 2010-03-19 UY UY0001032505A patent/UY32505A/es not_active Application Discontinuation
-
2011
- 2011-09-14 IL IL215139A patent/IL215139A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2012520859A (ja) | 2012-09-10 |
| RU2011142151A (ru) | 2013-04-27 |
| WO2010106290A1 (fr) | 2010-09-23 |
| UY32505A (es) | 2010-10-29 |
| US20120010241A1 (en) | 2012-01-12 |
| SG174466A1 (en) | 2011-10-28 |
| CA2755660A1 (fr) | 2010-09-23 |
| TW201038553A (en) | 2010-11-01 |
| AR075874A1 (es) | 2011-05-04 |
| IL215139A0 (en) | 2011-12-29 |
| CN102439003A (zh) | 2012-05-02 |
| KR20110128942A (ko) | 2011-11-30 |
| BRPI1009375A2 (pt) | 2016-03-15 |
| AU2010224652A1 (en) | 2011-10-13 |
| EP2408762A1 (fr) | 2012-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |