MX2009011783A - Inhibidores de iap. - Google Patents
Inhibidores de iap.Info
- Publication number
- MX2009011783A MX2009011783A MX2009011783A MX2009011783A MX2009011783A MX 2009011783 A MX2009011783 A MX 2009011783A MX 2009011783 A MX2009011783 A MX 2009011783A MX 2009011783 A MX2009011783 A MX 2009011783A MX 2009011783 A MX2009011783 A MX 2009011783A
- Authority
- MX
- Mexico
- Prior art keywords
- iap
- inhibitors
- general formula
- compounds
- useful
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Abstract
La invención proporciona nuevos inhibidores de IAP que son útiles como agentes terapéuticos para tratar enfermedades malignas, en donde los compuestos tienen la fórmula general U1 - M - U2 en donde M es un grupo de enlace que une de manera covalente a R2, R3, R4 o R5 de U1 a un grupo R2, R3, R4 o R5 de U2 teniendo U1 y U2 la fórmula general (I) (ver fórmula I) y G, X1, X2, R2, R3, R3´, R4, R4´ y R5 son como se describe en la presente.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91501007P | 2007-04-30 | 2007-04-30 | |
PCT/US2008/061891 WO2008134679A1 (en) | 2007-04-30 | 2008-04-29 | Inhibitors of iap |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009011783A true MX2009011783A (es) | 2009-12-04 |
Family
ID=39926122
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009011783A MX2009011783A (es) | 2007-04-30 | 2008-04-29 | Inhibidores de iap. |
Country Status (18)
Country | Link |
---|---|
US (1) | US8907092B2 (es) |
EP (1) | EP2148858A4 (es) |
JP (1) | JP5368428B2 (es) |
KR (1) | KR20100024923A (es) |
CN (1) | CN101687787A (es) |
AR (1) | AR066348A1 (es) |
AU (1) | AU2008245447C1 (es) |
BR (1) | BRPI0809867A2 (es) |
CA (1) | CA2683392A1 (es) |
CL (1) | CL2008001234A1 (es) |
IL (1) | IL201379A0 (es) |
MX (1) | MX2009011783A (es) |
NZ (2) | NZ598890A (es) |
PE (2) | PE20090211A1 (es) |
RU (1) | RU2491276C2 (es) |
TW (1) | TWI432212B (es) |
WO (1) | WO2008134679A1 (es) |
ZA (1) | ZA200906946B (es) |
Families Citing this family (88)
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TWI543988B (zh) | 2006-03-16 | 2016-08-01 | 科學製藥股份有限公司 | 結合於細胞凋亡抑制蛋白(iap)之桿狀病毒iap重複序列(bir)區域之化合物 |
CN101516904A (zh) | 2006-07-24 | 2009-08-26 | 泰特拉洛吉克药业公司 | 二聚的iap拮抗剂 |
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-
2008
- 2008-04-29 MX MX2009011783A patent/MX2009011783A/es not_active Application Discontinuation
- 2008-04-29 CN CN200880022901A patent/CN101687787A/zh active Pending
- 2008-04-29 KR KR1020097024828A patent/KR20100024923A/ko active IP Right Grant
- 2008-04-29 NZ NZ598890A patent/NZ598890A/xx not_active IP Right Cessation
- 2008-04-29 TW TW097115740A patent/TWI432212B/zh not_active IP Right Cessation
- 2008-04-29 NZ NZ580226A patent/NZ580226A/xx not_active IP Right Cessation
- 2008-04-29 RU RU2009144094/04A patent/RU2491276C2/ru not_active IP Right Cessation
- 2008-04-29 JP JP2010506573A patent/JP5368428B2/ja not_active Expired - Fee Related
- 2008-04-29 PE PE2008000757A patent/PE20090211A1/es not_active Application Discontinuation
- 2008-04-29 CA CA002683392A patent/CA2683392A1/en not_active Abandoned
- 2008-04-29 PE PE2012001805A patent/PE20130150A1/es not_active Application Discontinuation
- 2008-04-29 BR BRPI0809867-0A patent/BRPI0809867A2/pt not_active IP Right Cessation
- 2008-04-29 EP EP08747109A patent/EP2148858A4/en not_active Withdrawn
- 2008-04-29 AU AU2008245447A patent/AU2008245447C1/en not_active Ceased
- 2008-04-29 CL CL200801234A patent/CL2008001234A1/es unknown
- 2008-04-29 AR ARP080101812A patent/AR066348A1/es not_active Application Discontinuation
- 2008-04-29 US US12/598,027 patent/US8907092B2/en not_active Expired - Fee Related
- 2008-04-29 WO PCT/US2008/061891 patent/WO2008134679A1/en active Application Filing
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2009
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- 2009-10-11 IL IL201379A patent/IL201379A0/en unknown
Also Published As
Publication number | Publication date |
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NZ580226A (en) | 2012-11-30 |
KR20100024923A (ko) | 2010-03-08 |
TW200902067A (en) | 2009-01-16 |
WO2008134679A1 (en) | 2008-11-06 |
RU2009144094A (ru) | 2011-06-10 |
BRPI0809867A2 (pt) | 2014-09-30 |
JP5368428B2 (ja) | 2013-12-18 |
CN101687787A (zh) | 2010-03-31 |
AR066348A1 (es) | 2009-08-12 |
ZA200906946B (en) | 2011-05-25 |
CL2008001234A1 (es) | 2008-09-22 |
US20110077265A1 (en) | 2011-03-31 |
EP2148858A4 (en) | 2011-01-26 |
AU2008245447C1 (en) | 2014-11-20 |
RU2491276C2 (ru) | 2013-08-27 |
AU2008245447A1 (en) | 2008-11-06 |
PE20130150A1 (es) | 2013-02-27 |
PE20090211A1 (es) | 2009-04-02 |
TWI432212B (zh) | 2014-04-01 |
EP2148858A1 (en) | 2010-02-03 |
JP2010526079A (ja) | 2010-07-29 |
AU2008245447B2 (en) | 2014-01-23 |
NZ598890A (en) | 2013-10-25 |
US8907092B2 (en) | 2014-12-09 |
IL201379A0 (en) | 2010-05-31 |
CA2683392A1 (en) | 2008-11-06 |
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