MX2009009428A - Analogos de ciclopamina heterociclicos y metodos de uso de los mismos. - Google Patents

Analogos de ciclopamina heterociclicos y metodos de uso de los mismos.

Info

Publication number
MX2009009428A
MX2009009428A MX2009009428A MX2009009428A MX2009009428A MX 2009009428 A MX2009009428 A MX 2009009428A MX 2009009428 A MX2009009428 A MX 2009009428A MX 2009009428 A MX2009009428 A MX 2009009428A MX 2009009428 A MX2009009428 A MX 2009009428A
Authority
MX
Mexico
Prior art keywords
methods
cyclopamine analogs
heterocyclic
heterocyclic cyclopamine
analogs
Prior art date
Application number
MX2009009428A
Other languages
English (en)
Inventor
Alfredo C Castro
Michael J Grogan
Martin R Tremblay
Original Assignee
Infinity Discovery Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infinity Discovery Inc filed Critical Infinity Discovery Inc
Publication of MX2009009428A publication Critical patent/MX2009009428A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invenci?n se relaciona a compuestos similares a alcaloides esteroidales que se pueden utilizar en el tratamiento de des?rdenes relacionados con la ruta hedgehog, particularmente c?ncer.
MX2009009428A 2007-03-07 2008-03-07 Analogos de ciclopamina heterociclicos y metodos de uso de los mismos. MX2009009428A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89359507P 2007-03-07 2007-03-07
PCT/US2008/003200 WO2008109184A1 (en) 2007-03-07 2008-03-07 Heterocyclic cyclopamine analogs and methods of use thereof

Publications (1)

Publication Number Publication Date
MX2009009428A true MX2009009428A (es) 2010-04-27

Family

ID=39738651

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009428A MX2009009428A (es) 2007-03-07 2008-03-07 Analogos de ciclopamina heterociclicos y metodos de uso de los mismos.

Country Status (15)

Country Link
US (3) US7648994B2 (es)
EP (1) EP2129677B1 (es)
JP (1) JP2010520295A (es)
KR (1) KR20090117957A (es)
CN (1) CN101687877B (es)
AU (1) AU2008223355B2 (es)
BR (1) BRPI0808663A2 (es)
CA (1) CA2680186A1 (es)
HK (1) HK1139657A1 (es)
IL (1) IL200684A0 (es)
MX (1) MX2009009428A (es)
NZ (1) NZ579361A (es)
RU (1) RU2009137014A (es)
WO (1) WO2008109184A1 (es)
ZA (1) ZA200906089B (es)

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Also Published As

Publication number Publication date
US20080293755A1 (en) 2008-11-27
US8426436B2 (en) 2013-04-23
US20100144775A1 (en) 2010-06-10
JP2010520295A (ja) 2010-06-10
CN101687877A (zh) 2010-03-31
AU2008223355A1 (en) 2008-09-12
US20120065218A1 (en) 2012-03-15
CA2680186A1 (en) 2008-09-12
US7648994B2 (en) 2010-01-19
RU2009137014A (ru) 2011-04-20
US7994191B2 (en) 2011-08-09
IL200684A0 (en) 2010-05-17
BRPI0808663A2 (pt) 2014-08-26
ZA200906089B (en) 2011-02-23
AU2008223355B2 (en) 2014-03-20
HK1139657A1 (en) 2010-09-24
KR20090117957A (ko) 2009-11-16
EP2129677A1 (en) 2009-12-09
NZ579361A (en) 2012-04-27
CN101687877B (zh) 2014-07-23
EP2129677B1 (en) 2014-12-17
WO2008109184A1 (en) 2008-09-12
EP2129677A4 (en) 2012-02-01

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