MX2009008103A - Compuestos anulares fusionados como agonistas parciales de prar-gamma. - Google Patents

Compuestos anulares fusionados como agonistas parciales de prar-gamma.

Info

Publication number
MX2009008103A
MX2009008103A MX2009008103A MX2009008103A MX2009008103A MX 2009008103 A MX2009008103 A MX 2009008103A MX 2009008103 A MX2009008103 A MX 2009008103A MX 2009008103 A MX2009008103 A MX 2009008103A MX 2009008103 A MX2009008103 A MX 2009008103A
Authority
MX
Mexico
Prior art keywords
ppar
gamma
fused ring
partial agonists
ring compounds
Prior art date
Application number
MX2009008103A
Other languages
English (en)
Inventor
Nobuo Cho
Taisuke Tawaraishi
Hiroshi Imoto
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39523585&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009008103(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of MX2009008103A publication Critical patent/MX2009008103A/es

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)

Abstract

La presente invención provee un agente para la prevención o el tratamiento de diabetes, que tiene una acción hipoglucémica superior, y está asociado con menos efectos secundarios tales como aumento de peso corporal, y similares. La presente invención se refiere a un agente para la prevención o el tratamiento de diabetes, que comprende un compuesto representado por (ver fórmula (I')) en donde cada símbolo es como se definió en la descripción, o una de sus sales o uno de sus profármacos.
MX2009008103A 2007-02-09 2008-02-05 Compuestos anulares fusionados como agonistas parciales de prar-gamma. MX2009008103A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007031221 2007-02-09
PCT/JP2008/052217 WO2008099794A1 (en) 2007-02-09 2008-02-05 Fused ring compounds as partial agonists of ppar-gamma

Publications (1)

Publication Number Publication Date
MX2009008103A true MX2009008103A (es) 2009-08-18

Family

ID=39523585

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009008103A MX2009008103A (es) 2007-02-09 2008-02-05 Compuestos anulares fusionados como agonistas parciales de prar-gamma.

Country Status (21)

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US (2) US20110009384A1 (es)
EP (1) EP2118066A1 (es)
JP (1) JP2010517935A (es)
KR (1) KR20090106660A (es)
CN (1) CN101646653A (es)
AR (1) AR065206A1 (es)
AU (1) AU2008215490A1 (es)
BR (1) BRPI0807014A2 (es)
CA (1) CA2677736A1 (es)
CL (1) CL2008000377A1 (es)
CR (1) CR10991A (es)
DO (1) DOP2009000202A (es)
EA (1) EA200970746A1 (es)
EC (1) ECSP099618A (es)
IL (1) IL200114A0 (es)
MA (1) MA31189B1 (es)
MX (1) MX2009008103A (es)
PE (1) PE20090068A1 (es)
TN (1) TN2009000312A1 (es)
TW (1) TW200838515A (es)
WO (1) WO2008099794A1 (es)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009097995A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
TW201014850A (en) 2008-09-25 2010-04-16 Takeda Pharmaceutical Solid pharmaceutical composition
US8501804B2 (en) 2008-10-27 2013-08-06 Takeda Pharmaceutical Company Limited Bicyclic compound
US9045453B2 (en) 2008-11-14 2015-06-02 Concert Pharmaceuticals, Inc. Substituted dioxopiperidinyl phthalimide derivatives
ES2444433T3 (es) * 2008-11-14 2014-02-25 Concert Pharmaceuticals, Inc. Derivados de dioxopiperidinil-ftalimida sustituidos
JPWO2010076884A1 (ja) 2008-12-29 2012-06-21 武田薬品工業株式会社 新規縮合環化合物およびその用途
WO2010143733A1 (en) 2009-06-09 2010-12-16 Takeda Pharmaceutical Company Limited Novel fused cyclic compound and use thereof
EP2460523B1 (en) 2009-07-28 2017-01-04 Takeda Pharmaceutical Company Limited Tablet
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
UY33354A (es) 2010-04-27 2011-12-01 Takeda Pharmaceutical Compuesto biciclico como inhibidor acc
SG186223A1 (en) 2010-06-16 2013-01-30 Takeda Pharmaceutical Crystal of amide compound
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
EP2617726A4 (en) 2010-09-17 2014-05-14 Takeda Pharmaceutical DIABETES THERAPEUTIC
AR084032A1 (es) 2010-11-30 2013-04-17 Takeda Pharmaceutical Compuesto biciclico
SG192645A1 (en) 2011-02-17 2013-09-30 Takeda Pharmaceutical Production method of optically active dihydrobenzofuran derivative
CN102816205B (zh) * 2011-06-09 2014-12-10 中国科学院上海生命科学研究院 β抑制蛋白1、其片段及其应用
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013061962A1 (ja) 2011-10-24 2013-05-02 武田薬品工業株式会社 二環性化合物
WO2013068486A1 (en) 2011-11-08 2013-05-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the diagnosis and treatment of male infertility
US9365540B2 (en) 2012-01-12 2016-06-14 Takeda Pharmaceutical Company Limited Benzimidazole derivatives as MCH receptor antagonists
US9382188B2 (en) 2012-02-13 2016-07-05 Takeda Pharmaceutical Company Limited Aromatic ring compound
JP6121339B2 (ja) 2012-02-13 2017-04-26 武田薬品工業株式会社 芳香環化合物
EP2814466B1 (en) 2012-02-15 2018-12-26 Takeda Pharmaceutical Company Limited Tablet comprising 1-(4-methoxybutyl)-n-(2-methylpropyl)-n-[(3s,5r)-5-(morpholin-4-ylcarbonyl)piperidin-3-yl]-1h-benzimidazole-2-carboxamide or a salt thereof
ES2640258T3 (es) 2012-02-24 2017-11-02 Takeda Pharmaceutical Company Limited Compuesto anular aromático como inhibidor de grelina o-aciltransferasa
JPWO2013147026A1 (ja) 2012-03-29 2015-12-14 武田薬品工業株式会社 芳香環化合物
EP2848622A4 (en) 2012-05-10 2015-11-04 Takeda Pharmaceutical AROMATIC RING CONNECTION
EP2848621A4 (en) 2012-05-10 2016-06-01 Takeda Pharmaceutical AROMATIC CYCLIC COMPOUND
RU2645344C2 (ru) 2012-05-18 2018-02-21 Санофи Производные пиразола и их применение в качестве lpar5 антагонистов
WO2013171316A1 (en) 2012-05-18 2013-11-21 Sanofi Pyridine derivatives and their use in the treatment of conditions associated with pathological thrombus formation
KR102145641B1 (ko) 2012-06-05 2020-08-18 다케다 야쿠힌 고교 가부시키가이샤 고형 제제
JP2015127299A (ja) 2012-07-19 2015-07-09 武田薬品工業株式会社 固形製剤
JP2015534989A (ja) 2012-10-22 2015-12-07 コンサート ファーマシューティカルズ インコーポレイテッド ｛ｓ−３−（４−アミノ−１−オキソ−イソインドリン−２−イル）（ピペリジン−３，４，４，５，５−ｄ５）−２，６−ジオン｝の固体形態
US9605000B2 (en) 2013-03-14 2017-03-28 Takeda Pharmaceutical Company Limited Spiro azetidine isoxazole derivatives and their use as SSTR antagonists
US10005720B2 (en) 2013-04-05 2018-06-26 North Carolina Central University Compounds useful for the treatment of metabolic disorders and synthesis of the same
UY35650A (es) 2013-07-09 2015-02-27 Takeda Pharmaceutical Compuesto heterocíclico
EP3031799B1 (en) 2013-08-09 2018-04-04 Takeda Pharmaceutical Company Limited Aromatic compound
JO3442B1 (ar) 2013-10-07 2019-10-20 Takeda Pharmaceuticals Co مضادات ذات نوع فرعي من مستقبل سوماتوستاتين 5 (sstr5)
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
WO2016105118A2 (ko) 2014-12-24 2016-06-30 주식회사 엘지생명과학 Gpr120 효능제로서의 바이아릴 유도체
US10445126B2 (en) * 2017-02-21 2019-10-15 Red Hat, Inc. Preloading enhanced application startup
JOP20180029A1 (ar) 2017-03-30 2019-01-30 Takeda Pharmaceuticals Co مركب حلقي غير متجانس
WO2018181847A1 (ja) 2017-03-31 2018-10-04 武田薬品工業株式会社 芳香環化合物
AR111199A1 (es) 2017-03-31 2019-06-12 Takeda Pharmaceuticals Co Compuesto aromático agonista de gpr40
JOP20180028A1 (ar) 2017-03-31 2019-01-30 Takeda Pharmaceuticals Co مركب ببتيد
US10471045B2 (en) * 2017-07-21 2019-11-12 The University Of Hong Kong Compounds and methods for the treatment of microbial infections
WO2019166633A1 (en) * 2018-03-02 2019-09-06 Inflazome Limited Sulfonamide derivates as nlrp3 inhibitors
US11834433B2 (en) 2018-03-02 2023-12-05 Inflazome Limited Compounds
US11530200B2 (en) 2018-03-02 2022-12-20 Inflazome Limited Compounds
WO2019166628A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
EA202092269A1 (ru) 2018-03-23 2020-12-14 Кармот Терапьютикс, Инк. Модуляторы сопряженных с g-белком рецепторов
AR116019A1 (es) 2018-08-27 2021-03-25 Scohia Pharma Inc Derivados de guanidinobenzoilo como inhibidores de enteropeptidasa
EP3856768A2 (en) 2018-09-24 2021-08-04 Takeda Pharmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
US20220016215A1 (en) 2018-09-24 2022-01-20 Takeda Phaarmaceutical Company Limited Gip receptor agonist peptide compounds and uses thereof
PE20221727A1 (es) 2020-03-25 2022-11-04 Takeda Pharmaceuticals Co Dosificacion qw de compuestos peptidicos agonistas del receptor de gip y sus usos
KR20230005184A (ko) 2020-03-25 2023-01-09 다케다 야쿠힌 고교 가부시키가이샤 Gip 수용체 작용제 펩티드 화합물의 qd 투약 및 이의 용도
EP4337682A2 (en) 2021-05-13 2024-03-20 Carmot Therapeutics Inc. Modulators of g-protein coupled receptors
WO2023169456A1 (en) 2022-03-09 2023-09-14 Gasherbrum Bio , Inc. Heterocyclic glp-1 agonists
WO2023179542A1 (en) 2022-03-21 2023-09-28 Gasherbrum Bio , Inc. 5,8-dihydro-1,7-naphthyridine derivatives as glp-1 agonists for the treatment of diabetes
WO2023198140A1 (en) 2022-04-14 2023-10-19 Gasherbrum Bio, Inc. Heterocyclic glp-1 agonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939442A (en) * 1995-06-07 1999-08-17 The Salk Institute For Biological Studies Modulations of peroxisome proliferator activated receptor-γ, and methods for the use thereof
US6413994B1 (en) * 1999-02-22 2002-07-02 The Salk Institute For Biological Studies Modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
WO1999035147A1 (fr) * 1998-01-05 1999-07-15 Eisai Co., Ltd. Derives de purine et antagonistes du recepteur a2 d'adenosine utiles comme moyens de prevention/traitement du diabete
TR200101865T2 (tr) * 1998-12-24 2001-12-21 Fujisawa Pharmaceutical Co .Ltd. İmidazol bileşimleri ve onların tıbbi kullanımları.
IL155447A0 (en) * 2000-10-20 2003-11-23 Eisai Co Ltd Nitrogenous aromatic ring compounds
WO2003099793A1 (en) * 2002-05-24 2003-12-04 Takeda Pharmaceutical Company Limited 1,2-azole derivatives with hypoglycemic and hypolipidemic activity
US7317032B2 (en) * 2003-09-02 2008-01-08 Bristol-Myers Squibb Co. Imidazolyl inhibitors of 15-lipoxygenase
US7432271B2 (en) * 2003-09-02 2008-10-07 Bristol-Myers Squibb Company Pyrazolyl inhibitors of 15-lipoxygenase
WO2006075955A1 (en) * 2005-01-13 2006-07-20 Astrazeneca Ab Pyrazolyl acylsulfonamide derivatives as endothelin converting enzyme inhibitors and useful in the treatment of chronic obstructive pulmonary disease

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