MX2009006873A - Promotores de desintegracion en formulaciones de granulacion humeda de dosis solida. - Google Patents
Promotores de desintegracion en formulaciones de granulacion humeda de dosis solida.Info
- Publication number
- MX2009006873A MX2009006873A MX2009006873A MX2009006873A MX2009006873A MX 2009006873 A MX2009006873 A MX 2009006873A MX 2009006873 A MX2009006873 A MX 2009006873A MX 2009006873 A MX2009006873 A MX 2009006873A MX 2009006873 A MX2009006873 A MX 2009006873A
- Authority
- MX
- Mexico
- Prior art keywords
- wet granulation
- solid dose
- disintegrant
- formula
- dosage form
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se describe una forma de dosificación sólida de desintegración rápida que comprende un ingrediente farmacéutico activo, un desintegrador y un promotor de desintegración, cuya formulación se puede obtener mediante un procedimiento de granulación húmeda; en una modalidad ejemplificada, el agente farmacéutico activo es un antagonista del receptor de trombina, el desintegrador es croscarmelosa de sodio, y el promotor de desintegración es silicato de calcio; en algunas modalidades, el antagonista del receptor de trombina está representado por la fórmula: (ver fórmula) o su sal farmacéuticamente aceptable; también se describen métodos para tratar pacientes en riesgo de síndrome coronario agudo mediante la administración de dicha forma de dosificación sólida de desintegración rápida.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87160506P | 2006-12-22 | 2006-12-22 | |
PCT/US2007/025996 WO2008079260A2 (en) | 2006-12-22 | 2007-12-19 | Disintegration promoters in solid dose wet granulation formulations |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009006873A true MX2009006873A (es) | 2009-07-03 |
Family
ID=39467196
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009006873A MX2009006873A (es) | 2006-12-22 | 2007-12-19 | Promotores de desintegracion en formulaciones de granulacion humeda de dosis solida. |
Country Status (6)
Country | Link |
---|---|
US (1) | US20080194560A1 (es) |
EP (1) | EP2120879A2 (es) |
JP (1) | JP2010513516A (es) |
CA (1) | CA2673228A1 (es) |
MX (1) | MX2009006873A (es) |
WO (1) | WO2008079260A2 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI367112B (en) * | 2006-06-30 | 2012-07-01 | Schering Corp | Immediate-release tablet formulations of a thrombin receptor antagonist |
CN101465825B (zh) * | 2008-12-31 | 2012-07-11 | 阿里巴巴集团控股有限公司 | 即时通信的方法、即时通信服务器、语音服务器及系统 |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4304773A (en) * | 1980-06-26 | 1981-12-08 | E. R. Squibb & Sons, Inc. | Novel bendroflumethiazide formulations and method |
FR2623810B2 (fr) * | 1987-02-17 | 1992-01-24 | Sanofi Sa | Sels de l'alpha-(tetrahydro-4,5,6,7 thieno(3,2-c) pyridyl-5) (chloro-2 phenyl) -acetate de methyle dextrogyre et compositions pharmaceutiques en contenant |
US5576328A (en) * | 1994-01-31 | 1996-11-19 | Elf Sanofi | Method for the secondary prevention of ischemic events |
US6063847A (en) * | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
FR2779726B1 (fr) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | Forme polymorphe de l'hydrogenosulfate de clopidogrel |
AU5895500A (en) * | 1999-06-29 | 2001-01-31 | Cor Therapeutics, Inc. | Novel indazole peptidomimetics as thrombin receptor antagonists |
KR100604742B1 (ko) * | 2000-06-15 | 2006-07-26 | 쉐링 코포레이션 | 트롬빈 수용체 길항제 |
US7488742B2 (en) * | 2000-06-15 | 2009-02-10 | Schering Corporation | Thrombin receptor antagonists |
US20040192753A1 (en) * | 2000-06-15 | 2004-09-30 | Samuel Chackalamannil | Methods of use of thrombin receptor antagonists |
US7235567B2 (en) * | 2000-06-15 | 2007-06-26 | Schering Corporation | Crystalline polymorph of a bisulfate salt of a thrombin receptor antagonist |
US6521270B1 (en) * | 2001-06-11 | 2003-02-18 | The Procter & Gamble Company | Compositions comprising nitrofurantoin and uva ursi |
TWI324074B (en) * | 2001-10-09 | 2010-05-01 | Bristol Myers Squibb Co | Flashmelt oral dosage formulation |
EP1436298B1 (en) * | 2001-10-18 | 2011-09-21 | Schering Corporation | Himbacine analogues as thrombin receptor antagonists |
ATE494284T1 (de) * | 2002-04-16 | 2011-01-15 | Schering Corp | Tricyclischer thrombinrezeptorantagonist |
JP2004238348A (ja) * | 2003-02-07 | 2004-08-26 | Fuji Pharmaceutical Co Ltd | 経口投与用イトラコナゾール製剤 |
DE10317816A1 (de) * | 2003-04-16 | 2004-11-04 | Claas Selbstfahrende Erntemaschinen Gmbh | Feldhäcksler mit positionierbarer Fahrerkabine |
DE10355461A1 (de) * | 2003-11-27 | 2005-06-23 | Bayer Healthcare Ag | Verfahren zur Herstellung einer festen, oral applizierbaren pharmazeutischen Zusammensetzung |
JP2009542677A (ja) * | 2006-06-30 | 2009-12-03 | シェーリング コーポレイション | トロンビン受容体拮抗薬の固形製剤 |
TWI367112B (en) * | 2006-06-30 | 2012-07-01 | Schering Corp | Immediate-release tablet formulations of a thrombin receptor antagonist |
TWI343262B (en) * | 2006-09-26 | 2011-06-11 | Schering Corp | Rapidly disintegrating lyophilized oral formulations of a thrombin receptor antagonist |
-
2007
- 2007-12-19 CA CA002673228A patent/CA2673228A1/en not_active Abandoned
- 2007-12-19 WO PCT/US2007/025996 patent/WO2008079260A2/en active Application Filing
- 2007-12-19 EP EP07867849A patent/EP2120879A2/en not_active Withdrawn
- 2007-12-19 US US11/960,320 patent/US20080194560A1/en not_active Abandoned
- 2007-12-19 MX MX2009006873A patent/MX2009006873A/es not_active Application Discontinuation
- 2007-12-19 JP JP2009542908A patent/JP2010513516A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
EP2120879A2 (en) | 2009-11-25 |
CA2673228A1 (en) | 2008-07-03 |
WO2008079260A3 (en) | 2008-09-25 |
US20080194560A1 (en) | 2008-08-14 |
WO2008079260A2 (en) | 2008-07-03 |
JP2010513516A (ja) | 2010-04-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |