MX2007004183A - Derivados de benzoimidazol utiles como agentes antiproliferacion. - Google Patents

Derivados de benzoimidazol utiles como agentes antiproliferacion.

Info

Publication number
MX2007004183A
MX2007004183A MX2007004183A MX2007004183A MX2007004183A MX 2007004183 A MX2007004183 A MX 2007004183A MX 2007004183 A MX2007004183 A MX 2007004183A MX 2007004183 A MX2007004183 A MX 2007004183A MX 2007004183 A MX2007004183 A MX 2007004183A
Authority
MX
Mexico
Prior art keywords
derivatives useful
antiproliferative agents
benzoimidazole derivatives
formula
relates
Prior art date
Application number
MX2007004183A
Other languages
English (en)
Inventor
John Charles Kath
Kirk Russell Henne
Ruby Anthea Szewc
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MX2007004183A publication Critical patent/MX2007004183A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invencion se refiere a compuestos sustancialmente puros de formula 1 Y a sales farmaceuticamente aceptables, profarmacos y solvatos de los mismos, en la que R, R1, R2, R3, R4 y R5 son como se han definido anteriormente; la invencion tambien se refiere a composiciones farmaceuticas que comprenden los compuestos de formula 1 y procedimientos para tratar el crecimiento celular anormal, tal como cancer, en mamiferos, mediante la administracion de dichas formulaciones farmaceuticas.
MX2007004183A 2004-10-07 2005-10-03 Derivados de benzoimidazol utiles como agentes antiproliferacion. MX2007004183A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61697804P 2004-10-07 2004-10-07
PCT/IB2005/003034 WO2006038111A1 (en) 2004-10-07 2005-10-03 Benzoimidazole derivatives useful as antiproliferative agents

Publications (1)

Publication Number Publication Date
MX2007004183A true MX2007004183A (es) 2007-06-07

Family

ID=35520072

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004183A MX2007004183A (es) 2004-10-07 2005-10-03 Derivados de benzoimidazol utiles como agentes antiproliferacion.

Country Status (7)

Country Link
US (1) US20100016353A1 (es)
EP (1) EP1799670A1 (es)
JP (1) JP2008515872A (es)
BR (1) BRPI0516453A (es)
CA (1) CA2582479C (es)
MX (1) MX2007004183A (es)
WO (1) WO2006038111A1 (es)

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US8051425B2 (en) * 2004-10-29 2011-11-01 Emc Corporation Distributed system with asynchronous execution systems and methods
US8055711B2 (en) * 2004-10-29 2011-11-08 Emc Corporation Non-blocking commit protocol systems and methods
US7551572B2 (en) * 2005-10-21 2009-06-23 Isilon Systems, Inc. Systems and methods for providing variable protection
US7917474B2 (en) * 2005-10-21 2011-03-29 Isilon Systems, Inc. Systems and methods for accessing and updating distributed data
US7756898B2 (en) * 2006-03-31 2010-07-13 Isilon Systems, Inc. Systems and methods for notifying listeners of events
FR2901135B1 (fr) * 2006-05-22 2017-12-08 Oreal Utilisation de modulateurs de la glycolyse comme agents diminuant la proliferation des keratinocytes
US7822932B2 (en) * 2006-08-18 2010-10-26 Isilon Systems, Inc. Systems and methods for providing nonlinear journaling
US7680836B2 (en) * 2006-08-18 2010-03-16 Isilon Systems, Inc. Systems and methods for a snapshot of data
US7899800B2 (en) * 2006-08-18 2011-03-01 Isilon Systems, Inc. Systems and methods for providing nonlinear journaling
US7590652B2 (en) * 2006-08-18 2009-09-15 Isilon Systems, Inc. Systems and methods of reverse lookup
US20080155191A1 (en) * 2006-12-21 2008-06-26 Anderson Robert J Systems and methods for providing heterogeneous storage systems
US8286029B2 (en) 2006-12-21 2012-10-09 Emc Corporation Systems and methods for managing unavailable storage devices
MY157724A (en) 2007-04-03 2016-07-15 Array Biopharma Inc IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS
US7779048B2 (en) 2007-04-13 2010-08-17 Isilon Systems, Inc. Systems and methods of providing possible value ranges
US7966289B2 (en) * 2007-08-21 2011-06-21 Emc Corporation Systems and methods for reading objects in a file system
HU230981B1 (hu) * 2007-10-12 2019-08-28 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás rosuvastatin só előállítására
HU230637B1 (hu) * 2007-10-12 2017-05-29 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Eljárás rosuvastatin intermedierek előállítására
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
WO2011163355A1 (en) 2010-06-24 2011-12-29 Takeda Pharmaceutical Company Limited Fused heterocyclic compounds as phosphodiesterases (pdes) inhibitors
TWI570122B (zh) * 2011-06-22 2017-02-11 武田藥品工業股份有限公司 稠合雜環化合物之結晶
WO2014031445A1 (en) 2012-08-22 2014-02-27 Merck Sharp & Dohme Corp. Novel benzimidazole tetrahydropyran derivatives
JP6407504B2 (ja) * 2012-09-21 2018-10-17 アログ・ファーマシューティカルズ・インコーポレイテッドＡｒｏｇ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 恒常的に活性であるリン酸化型ｆｌｔ３キナーゼの阻害方法
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
KR20230049102A (ko) * 2020-08-05 2023-04-12 더 제너럴 하스피탈 코포레이션 염 유도성 키나제 억제제

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA75055C2 (uk) * 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
PA8580301A1 (es) * 2002-08-28 2005-05-24 Pfizer Prod Inc Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
DE602004017731D1 (de) * 2003-06-24 2008-12-24 Pfizer Prod Inc Verfahren zur herstellung von 1-ä(benzimidazol-1-yl)chinolin-8-ylüpiperidin-4-ylaminderivaten

Also Published As

Publication number Publication date
BRPI0516453A (pt) 2008-09-02
CA2582479C (en) 2011-07-12
WO2006038111A1 (en) 2006-04-13
CA2582479A1 (en) 2006-04-13
US20100016353A1 (en) 2010-01-21
EP1799670A1 (en) 2007-06-27
JP2008515872A (ja) 2008-05-15

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