ME00129B - Triciklicnj benzodiazepini kao antagonisti receptora vazopresina - Google Patents

Triciklicnj benzodiazepini kao antagonisti receptora vazopresina

Info

Publication number
ME00129B
ME00129B MEP-2008-178A MEP17808A ME00129B ME 00129 B ME00129 B ME 00129B ME P17808 A MEP17808 A ME P17808A ME 00129 B ME00129 B ME 00129B
Authority
ME
Montenegro
Prior art keywords
receptor antagonists
heart failure
vasopressin receptor
tricyclic benzodiazepines
benzodiazepines
Prior art date
Application number
MEP-2008-178A
Other languages
English (en)
French (fr)
Inventor
William J Hoekstra
Alexey B Dyatkin
Bruce E Maryanoff
Jay M Matthews
Original Assignee
Ortho Mcneil Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Janssen Pharmaceuticals Inc filed Critical Ortho Mcneil Janssen Pharmaceuticals Inc
Publication of MEP17808A publication Critical patent/MEP17808A/xx
Publication of ME00129B publication Critical patent/ME00129B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Ovaj pronalazak se odnosi na triciklične benzodiazepine koji su korisni kao antagonisti receptora vazopresina prilikom tretiranja stanja koja obuhvataju povećanu vaskulamu rezistenciju i srčanu insuficijenciju. Opisani su takođe farmaceutski preparati koji sadrže triciklične benzodiazepine iz ovog pronalaska i postupci za tretiranje stanja kao što su hipertenzija, kongestivna srčana smetnja, srčana insuficijencija, koronarni vazospazam, srčana ishemija, ciroza jetre, bubrežni vazospazam, bubrežna smetnja, edem i ishemija mozga, moždani udar, tromboza ili retencija vode.
MEP-2008-178A 1999-01-19 1999-12-21 Triciklicnj benzodiazepini kao antagonisti receptora vazopresina ME00129B (me)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11635899P 1999-01-19 1999-01-19
US46865099A 1999-12-21 1999-12-21
PCT/US1999/030423 WO2000043398A2 (en) 1999-01-19 1999-12-21 Tricyclic benzodiazepines as vasopressin receptor antagonists

Publications (2)

Publication Number Publication Date
MEP17808A MEP17808A (en) 2010-06-10
ME00129B true ME00129B (me) 2010-10-10

Family

ID=26814157

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-178A ME00129B (me) 1999-01-19 1999-12-21 Triciklicnj benzodiazepini kao antagonisti receptora vazopresina

Country Status (27)

Country Link
US (2) US6713475B2 (me)
EP (1) EP1147115B3 (me)
KR (1) KR100771184B1 (me)
CN (1) CN1174986C (me)
AR (1) AR035837A1 (me)
AT (1) ATE249465T1 (me)
AU (1) AU772397B2 (me)
BR (1) BRPI9917086B8 (me)
CA (1) CA2360767C (me)
CZ (1) CZ302647B6 (me)
DE (2) DE69911259D1 (me)
DK (1) DK1147115T5 (me)
ES (1) ES2207333T7 (me)
HK (1) HK1038361B (me)
HU (1) HU229074B1 (me)
IL (2) IL144270A0 (me)
ME (1) ME00129B (me)
MY (1) MY128065A (me)
NO (1) NO327896B1 (me)
NZ (1) NZ512960A (me)
PL (1) PL205704B1 (me)
PT (1) PT1147115E (me)
RS (1) RS50820B (me)
TR (1) TR200102069T2 (me)
TW (1) TWI289564B (me)
UA (1) UA70984C2 (me)
WO (1) WO2000043398A2 (me)

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IL145684A (en) * 2000-10-04 2007-06-17 Warner Lambert Co Medications for the treatment of pulmonary hypertension
JP2004526771A (ja) 2001-04-12 2004-09-02 ワイス シクロヘキシルフェニルバソプレッシンアゴニスト
US6903091B2 (en) 2001-04-12 2005-06-07 Wyeth Biphenyl vasopressin agonists
PL370114A1 (en) 2001-10-29 2005-05-16 Ortho-Mcneil Pharmaceutical, Inc. Bridged bicycle (1,4) benzodiazepine vasopressin receptor antagonists
EP1364968A1 (en) * 2002-05-23 2003-11-26 Bayer Aktiengesellschaft Diagnostics and therapeutics for diseases associated with arginine vasopressin receptor 1 (AVPR1)
US7119088B2 (en) 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
DK1597260T3 (da) * 2003-02-19 2007-04-02 Pfizer Triazol forbindelser, der er anvendelige i behandling
US7763605B2 (en) 2004-10-28 2010-07-27 Janssen Pharmaceutica, N.V. [1,4]benzodiazepines as vasopressin V2 receptor antagonists
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
WO2008007661A1 (fr) * 2006-07-11 2008-01-17 Takeda Pharmaceutical Company Limited Composé hétérocyclique tricycique et son utilisation
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
JP5567027B2 (ja) * 2008-11-13 2014-08-06 エフ．ホフマン−ラ ロシュ アーゲー スピロ−５，６−ジヒドロ−４Ｈ−２，３，５，１０ｂ−テトラアザ−ベンゾ［ｅ］アズレン
PL2358714T3 (pl) * 2008-11-18 2012-12-31 Hoffmann La Roche Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu
NZ592076A (en) * 2008-11-28 2012-06-29 Hoffmann La Roche Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
DE102009033392A1 (de) * 2009-07-16 2011-01-20 Merck Patent Gmbh Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
JP2013505914A (ja) * 2009-09-24 2013-02-21 シャイア−モベティス エヌ．ブイ． バソプレシンｖ２受容体アンタゴニストとしての［１，４］−ベンゾジアゼピン
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
EP2575681B1 (en) 2010-05-25 2022-06-22 JenaValve Technology, Inc. Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US8828989B2 (en) 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
EP3038567B1 (en) 2013-08-30 2022-09-07 JenaValve Technology, Inc. Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
WO2016089797A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
WO2016089833A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
WO2016089830A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
WO2016177562A1 (en) 2015-05-01 2016-11-10 Jenavalve Technology, Inc. Device and method with reduced pacemaker rate in heart valve replacement
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JP7094965B2 (ja) 2017-01-27 2022-07-04 イエナバルブ テクノロジー インク 心臓弁模倣
EP3875078A1 (en) * 2020-03-06 2021-09-08 Dompe' Farmaceutici S.P.A. Compounds for the treatment of covid-19

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DE69911259D1 (de) * 1999-01-19 2003-10-16 Ortho Mcneil Pharm Inc Tricyclische benzodiazepine als vasopressin antagonisten

Also Published As

Publication number Publication date
BR9917086B1 (pt) 2013-12-03
AU772397B2 (en) 2004-04-29
DE69911259D1 (de) 2003-10-16
CA2360767C (en) 2009-11-03
BRPI9917086B8 (pt) 2016-05-24
DK1147115T3 (da) 2004-01-12
HK1038361B (zh) 2004-05-07
PT1147115E (pt) 2004-02-27
HU229074B1 (en) 2013-07-29
TR200102069T2 (tr) 2001-11-21
RS50820B (sr) 2010-08-31
HK1038361A1 (en) 2002-03-15
NO20013515D0 (no) 2001-07-16
HUP0105034A2 (hu) 2002-04-29
DE69911259T2 (de) 2004-12-02
MY128065A (en) 2007-01-31
EP1147115B3 (en) 2008-12-24
HUP0105034A3 (en) 2004-11-29
DK1147115T5 (da) 2008-12-08
US20020103373A1 (en) 2002-08-01
CZ302647B6 (cs) 2011-08-17
BR9917086A (pt) 2001-10-30
CN1339038A (zh) 2002-03-06
DE69911259T4 (de) 2009-07-09
AU772397C (en) 2000-08-07
NO20013515L (no) 2001-09-17
AU2201400A (en) 2000-08-07
US7317005B2 (en) 2008-01-08
EP1147115A2 (en) 2001-10-24
NO327896B1 (no) 2009-10-12
YU51901A (sh) 2004-03-12
AR035837A1 (es) 2004-07-21
US6713475B2 (en) 2004-03-30
NZ512960A (en) 2004-01-30
IL144270A (en) 2010-04-29
KR20010101577A (ko) 2001-11-14
EP1147115B1 (en) 2003-09-10
ES2207333T3 (es) 2004-05-16
ES2207333T7 (es) 2009-06-18
CN1174986C (zh) 2004-11-10
WO2000043398A2 (en) 2000-07-27
IL144270A0 (en) 2002-05-23
ATE249465T1 (de) 2003-09-15
KR100771184B1 (ko) 2007-10-29
WO2000043398A3 (en) 2001-01-11
UA70984C2 (uk) 2004-11-15
US20040242866A1 (en) 2004-12-02
PL205704B1 (pl) 2010-05-31
CZ20012598A3 (cs) 2002-08-14
CA2360767A1 (en) 2000-07-27
PL349778A1 (en) 2002-09-09
MEP17808A (en) 2010-06-10
TWI289564B (en) 2007-11-11

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