MA43417A - Agonistes améliorés du récepteur de l'apéline (apj) et leurs utilisations - Google Patents
Agonistes améliorés du récepteur de l'apéline (apj) et leurs utilisationsInfo
- Publication number
- MA43417A MA43417A MA043417A MA43417A MA43417A MA 43417 A MA43417 A MA 43417A MA 043417 A MA043417 A MA 043417A MA 43417 A MA43417 A MA 43417A MA 43417 A MA43417 A MA 43417A
- Authority
- MA
- Morocco
- Prior art keywords
- apeline
- apj
- agonists
- receptor
- enhanced
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
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- A61K31/425—Thiazoles
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- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C—CHEMISTRY; METALLURGY
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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US (4) | US10100059B2 (fr) |
EP (1) | EP3386976A1 (fr) |
JP (2) | JP2019501899A (fr) |
KR (1) | KR20180090852A (fr) |
CN (1) | CN108602806B (fr) |
AU (1) | AU2016366310C1 (fr) |
BR (1) | BR112018011784A2 (fr) |
CA (1) | CA3006205A1 (fr) |
CO (1) | CO2018005871A2 (fr) |
HK (1) | HK1255452A1 (fr) |
IL (1) | IL259634A (fr) |
MA (1) | MA43417A (fr) |
MX (2) | MX2018006979A (fr) |
PE (1) | PE20190258A1 (fr) |
RU (2) | RU2766148C1 (fr) |
WO (1) | WO2017100558A1 (fr) |
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Families Citing this family (18)
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JP6767878B2 (ja) | 2014-06-06 | 2020-10-14 | リサーチ トライアングル インスティテュート | アペリン受容体(apj)アゴニストおよびそれらの使用 |
BR112017024618B1 (pt) | 2015-05-20 | 2023-03-14 | Amgen Inc | Compostos agonistas de triazol do receptor apj, composições e usos relacionados |
MY189453A (en) | 2015-06-03 | 2022-02-14 | Bristol Myers Squibb Co | 4-hydroxy-3-(heteroaryl)pyridine-2-one apj agonists for use in the treatment of cardiovascular disorders |
PE20190258A1 (es) | 2015-12-09 | 2019-02-25 | Res Triangle Inst | Antagonistas del receptor de la apelina (apj) mejorados y usos de los mismos |
EP3452466B1 (fr) | 2016-05-03 | 2020-08-12 | Amgen Inc. | Composés triazole hétérocycliques utilisés en tant qu'agonistes du récepteur apj |
KR102541080B1 (ko) | 2016-10-12 | 2023-06-08 | 리서치 트라이앵글 인스티튜트 | 복소환식 아펠린 수용체(apj) 작용제 및 이의 용도 |
WO2018093580A1 (fr) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Composés de triazole pyridyle en tant qu'agonistes du récepteur apj |
EP3541805B1 (fr) | 2016-11-16 | 2020-10-14 | Amgen Inc. | Triazoles substitués par hétéroaryle utilisés en tant qu'agonistes du récepteur apj |
EP3541802A1 (fr) | 2016-11-16 | 2019-09-25 | Amgen Inc. | Composés de triazole substitués par alkyle en tant qu'agonistes du récepteur apj |
US10736883B2 (en) | 2016-11-16 | 2020-08-11 | Amgen Inc. | Triazole furan compounds as agonists of the APJ receptor |
WO2018093577A1 (fr) | 2016-11-16 | 2018-05-24 | Amgen Inc. | Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj |
US10906890B2 (en) | 2016-11-16 | 2021-02-02 | Amgen Inc. | Triazole phenyl compounds as agonists of the APJ receptor |
WO2019071073A1 (fr) | 2017-10-06 | 2019-04-11 | Forma Therapeutics, Inc. | Inhibition de la peptidase 30 spécifique de l'ubiquitine |
MA50509A (fr) | 2017-11-03 | 2021-06-02 | Amgen Inc | Agonistes de triazole fusionnés du récepteur apj |
US11807624B2 (en) | 2018-05-01 | 2023-11-07 | Amgen Inc. | Substituted pyrimidinones as agonists of the APJ receptor |
EP4218934A1 (fr) | 2018-10-05 | 2023-08-02 | Forma Therapeutics, Inc. | Inhibition de la protéase 30 spécifique de l'ubiquitine (usp30) |
WO2021041791A1 (fr) | 2019-08-29 | 2021-03-04 | Rti International, Inc. | Méthodes et utilisations pour agonistes de récepteur de l'apeline |
KR20230152025A (ko) * | 2021-02-25 | 2023-11-02 | 리서치 트라이앵글 인스티튜트 | 아펠린 수용체 작용제로서의 헤테로아릴 유도체 |
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-
2016
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- 2016-12-09 MX MX2018006979A patent/MX2018006979A/es unknown
- 2016-12-09 CA CA3006205A patent/CA3006205A1/fr active Pending
- 2016-12-09 JP JP2018530026A patent/JP2019501899A/ja active Pending
- 2016-12-09 AU AU2016366310A patent/AU2016366310C1/en active Active
- 2016-12-09 MA MA043417A patent/MA43417A/fr unknown
- 2016-12-09 EP EP16826220.2A patent/EP3386976A1/fr active Pending
- 2016-12-09 WO PCT/US2016/065808 patent/WO2017100558A1/fr active Application Filing
- 2016-12-09 CN CN201680081397.9A patent/CN108602806B/zh not_active Expired - Fee Related
- 2016-12-09 KR KR1020187018896A patent/KR20180090852A/ko not_active Application Discontinuation
- 2016-12-09 RU RU2018118568A patent/RU2766148C1/ru active
- 2016-12-09 RU RU2021133849A patent/RU2021133849A/ru unknown
- 2016-12-09 BR BR112018011784A patent/BR112018011784A2/pt not_active Application Discontinuation
- 2016-12-09 US US15/374,386 patent/US10100059B2/en not_active Ceased
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2018
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- 2021-02-26 JP JP2021029791A patent/JP7195356B2/ja active Active
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CO2018005871A2 (es) | 2018-07-10 |
AU2016366310A1 (en) | 2018-06-07 |
AU2016366310A8 (en) | 2021-06-03 |
USRE49594E1 (en) | 2023-08-01 |
CN108602806B (zh) | 2022-07-12 |
MX2022002026A (es) | 2022-03-11 |
PE20190258A1 (es) | 2019-02-25 |
MX2018006979A (es) | 2019-05-16 |
RU2766148C1 (ru) | 2022-02-08 |
KR20180090852A (ko) | 2018-08-13 |
US11535630B2 (en) | 2022-12-27 |
BR112018011784A2 (pt) | 2018-12-04 |
WO2017100558A1 (fr) | 2017-06-15 |
CN108602806A (zh) | 2018-09-28 |
AU2016366310C1 (en) | 2021-09-09 |
CA3006205A1 (fr) | 2017-06-15 |
US20170166577A1 (en) | 2017-06-15 |
ZA201803301B (en) | 2019-07-31 |
US20210070767A1 (en) | 2021-03-11 |
JP7195356B2 (ja) | 2022-12-23 |
AU2016366310B8 (en) | 2021-06-03 |
US10100059B2 (en) | 2018-10-16 |
JP2019501899A (ja) | 2019-01-24 |
US20180265518A1 (en) | 2018-09-20 |
EP3386976A1 (fr) | 2018-10-17 |
US10954247B2 (en) | 2021-03-23 |
IL259634A (en) | 2018-07-31 |
RU2021133849A (ru) | 2022-03-21 |
AU2016366310B2 (en) | 2021-05-20 |
JP2021100934A (ja) | 2021-07-08 |
HK1255452A1 (zh) | 2019-08-16 |
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