MA28774B1 - SOLID DOSING FORM OF WET HEPARIN - Google Patents

SOLID DOSING FORM OF WET HEPARIN

Info

Publication number
MA28774B1
MA28774B1 MA29506A MA29506A MA28774B1 MA 28774 B1 MA28774 B1 MA 28774B1 MA 29506 A MA29506 A MA 29506A MA 29506 A MA29506 A MA 29506A MA 28774 B1 MA28774 B1 MA 28774B1
Authority
MA
Morocco
Prior art keywords
heparin
wet
dosing form
pharmaceutical composition
solid dosing
Prior art date
Application number
MA29506A
Other languages
French (fr)
Inventor
Shingai Majuru
Brahma Singh
Nikhil Dhoot
Original Assignee
Emisphere Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emisphere Tech Inc filed Critical Emisphere Tech Inc
Publication of MA28774B1 publication Critical patent/MA28774B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/609—Amides, e.g. salicylamide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition pharmaceutique solide (telle qu'une forme de dosage solide) comprenant un agent d'administration et de l'héparine mouillée. L'inclusion d'héparine mouillée provoque, dans la composition pharmaceutique solide, beaucoup plus qu'une héparine non mouillée, une administration accrue de l'héparine. Sans aucun lien avec une théorie particulaire, les inventeurs estiment que du fait que la chaîne polymère d'héparine mouillée est déjà une forme « ouverte », alors que l'héparine non mouillée ne l'est pas, moins d'héparine mouillée est décomposée dans le tractus gastro-intestinal et est plus facilement absorbée dans l'estomac.The invention relates to a solid pharmaceutical composition (such as a solid dosage form) comprising a delivery agent and wet heparin. The inclusion of wet heparin causes, in the solid pharmaceutical composition, much more than a non-wetted heparin, increased administration of heparin. Without any connection with a particular theory, the inventors believe that because the wet heparin polymer chain is already an "open" form, while the non-wetted heparin is not, less wet heparin is decomposed in the gastrointestinal tract and is more easily absorbed into the stomach.

MA29506A 2004-05-06 2006-12-04 SOLID DOSING FORM OF WET HEPARIN MA28774B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56947504P 2004-05-06 2004-05-06
US57267904P 2004-05-19 2004-05-19
US59897804P 2004-08-04 2004-08-04

Publications (1)

Publication Number Publication Date
MA28774B1 true MA28774B1 (en) 2007-08-01

Family

ID=35320730

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29506A MA28774B1 (en) 2004-05-06 2006-12-04 SOLID DOSING FORM OF WET HEPARIN

Country Status (14)

Country Link
US (1) US8039018B2 (en)
EP (1) EP1750729A2 (en)
JP (1) JP2007536268A (en)
KR (1) KR20070008720A (en)
AU (1) AU2005240206B2 (en)
BR (1) BRPI0510226A (en)
CA (1) CA2564866A1 (en)
EC (1) ECSP067050A (en)
IL (1) IL178846A0 (en)
MA (1) MA28774B1 (en)
MX (1) MXPA06012841A (en)
NZ (1) NZ550894A (en)
RU (1) RU2006138703A (en)
WO (1) WO2005107773A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8273794B2 (en) * 2004-05-14 2012-09-25 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
AU2008316634B2 (en) * 2007-10-24 2014-02-27 Mannkind Corporation Method of preventing adverse effects by GLP-1
WO2011097148A2 (en) * 2010-02-04 2011-08-11 Parsons Lowell C Use of oral heparin preparations to treat urinary tract diseases and conditions
DK3326620T3 (en) 2010-12-16 2020-05-25 Novo Nordisk As SOLID COMPOSITIONS CONTAINING A GLP-1 AGONIST AND SALT OF N- (8- (2- HYDROXYBENZOYL) AMINO) CAPRYLIC ACID
RU2602601C2 (en) 2011-04-12 2016-11-20 Ново Нордиск А/С Double acylated glp-1 derivatives
AU2013234496B2 (en) 2012-03-22 2017-07-27 Novo Nordisk A/S Compositions of GLP-1 peptides and preparation thereof
HUE042757T2 (en) 2012-03-22 2019-07-29 Novo Nordisk As Compositions comprising a delivery agent and preparation thereof
EP2827845B1 (en) 2012-03-22 2018-12-26 Novo Nordisk A/S Compositions comprising a delivery agent and preparation thereof
US9993430B2 (en) 2012-06-20 2018-06-12 Novo Nordisk A/S Tablet formulation comprising semaglutide and a delivery agent
ES2960687T3 (en) 2018-02-02 2024-03-06 Novo Nordisk As Solid compositions comprising a GLP-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid and a lubricant
TWI829687B (en) * 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3510561A (en) 1965-05-20 1970-05-05 Canada Packers Ltd Sulfone-enhanced heparin absorption through mucous membranes
US5578323A (en) 1992-06-15 1996-11-26 Emisphere Technologies, Inc. Proteinoid carriers and methods for preparation and use thereof
US5541155A (en) 1994-04-22 1996-07-30 Emisphere Technologies, Inc. Acids and acid salts and their use in delivery systems
US5714167A (en) 1992-06-15 1998-02-03 Emisphere Technologies, Inc. Active agent transport systems
US6221367B1 (en) 1992-06-15 2001-04-24 Emisphere Technologies, Inc. Active agent transport systems
US5629020A (en) 1994-04-22 1997-05-13 Emisphere Technologies, Inc. Modified amino acids for drug delivery
US6331318B1 (en) 1994-09-30 2001-12-18 Emisphere Technologies Inc. Carbon-substituted diketopiperazine delivery systems
US5693338A (en) 1994-09-29 1997-12-02 Emisphere Technologies, Inc. Diketopiperazine-based delivery systems
US6916489B2 (en) 1992-06-15 2005-07-12 Emisphere Technologies, Inc. Active agent transport systems
US6610329B2 (en) 1993-04-22 2003-08-26 Emisphere Technologies Inc. Compositions for the delivery of antigens
US20040062773A1 (en) 1993-04-22 2004-04-01 Emisphere Technologies Inc. Compositions for the delivery of antigens
US5643957A (en) 1993-04-22 1997-07-01 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US20010003001A1 (en) 1993-04-22 2001-06-07 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
SE9302135D0 (en) 1993-06-18 1993-06-18 Kabi Pharmacia Ab NEW PHARMACEUTICAL COMPOSITION
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
US5965121A (en) 1995-03-31 1999-10-12 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6001347A (en) 1995-03-31 1999-12-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5866536A (en) 1995-03-31 1999-02-02 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
BR9604880A (en) 1995-03-31 1998-05-19 Emisphere Tech Inc Compound composition dosage unit form methods for administering a biologically active agent for preparing a composition for administering an active agent and for preparing a compound and pharmacological composition
US5989539A (en) 1995-03-31 1999-11-23 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US5820881A (en) 1995-04-28 1998-10-13 Emisphere Technologies, Inc. Microspheres of diamide-dicarboxylic acids
US5750147A (en) 1995-06-07 1998-05-12 Emisphere Technologies, Inc. Method of solubilizing and encapsulating itraconazole
AU2595697A (en) 1996-03-29 1997-10-22 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
JP2000512671A (en) 1996-06-14 2000-09-26 エミスフェアー テクノロジーズ インク Microencapsulated fragrance and preparation method
US6391303B1 (en) 1996-11-18 2002-05-21 Emisphere Technologies, Inc. Methods and compositions for inducing oral tolerance in mammals
US6358504B1 (en) 1997-02-07 2002-03-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6313088B1 (en) 1997-02-07 2001-11-06 Emisphere Technologies, Inc. 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents
IN186245B (en) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
WO1999044642A1 (en) 1998-03-05 1999-09-10 Phares Pharmaceutical Research Nv Pharmaceutical compositions and their use
US6949816B2 (en) * 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
IL140710A0 (en) 1998-07-27 2002-02-10 Emisphere Tech Inc Pulmonary delivery of active agents
US6440929B1 (en) 1998-07-27 2002-08-27 Emisphere Technologies, Inc. Pulmonary delivery of active agents
CN1313439C (en) 1998-08-07 2007-05-02 艾米斯菲尔技术有限公司 Compounds and compositions for delivering active agents
US6627228B1 (en) 1999-01-08 2003-09-30 Emisphere Technologies, Inc. Polymeric delivery agents and delivery agents compounds
AU3357800A (en) 1999-02-05 2000-08-25 Emisphere Technologies, Inc. Method of preparing alkylated salicylamides
AU3492100A (en) 1999-02-11 2000-08-29 Emisphere Technologies, Inc. Oxadiazole compounds and compositions for delivering active agents
AU3378100A (en) 1999-02-26 2000-09-14 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
IL145546A0 (en) 1999-04-05 2002-06-30 Emisphere Tech Inc Disodium salts, monohydrates, and ethanol solvates for delivering active agents
US6458383B2 (en) * 1999-08-17 2002-10-01 Lipocine, Inc. Pharmaceutical dosage form for oral administration of hydrophilic drugs, particularly low molecular weight heparin
CZ20021554A3 (en) 1999-11-05 2002-10-16 Emisphere Technologies, Inc. Derivatives of a phenoxycarboxylic compound and preparations for delivering active component
MXPA02004741A (en) 1999-11-12 2003-12-11 Emisphere Tech Inc Liquid heparin formulation.
US6693208B2 (en) 1999-12-16 2004-02-17 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
EP1246792B1 (en) 2000-01-13 2014-08-13 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US6384278B1 (en) 2000-02-04 2002-05-07 Emisphere Technologies, Inc. Boron-mediated amidation of carboxylic acids
SE0000774D0 (en) 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
WO2001070219A1 (en) 2000-03-21 2001-09-27 Emisphere Technologies, Inc. Method of preparing alkylated salicylamides via a dicarboxylate intermediate
AU2001275231A1 (en) 2000-06-02 2001-12-11 Emisphere Technologies, Inc. Method of preparing salicylamides
DE60133555T2 (en) 2000-06-29 2008-09-18 Emisphere Technologies, Inc. COMPOUNDS AND MIXTURES FOR THE ADMINISTRATION OF AN ACTIVE AGENCY
US7138546B2 (en) 2000-08-18 2006-11-21 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
JP4707931B2 (en) 2000-08-18 2011-06-22 エミスフェアー・テクノロジーズ・インク Active agent delivery compounds and compositions
JP5089845B2 (en) 2000-09-06 2012-12-05 エミスフェアー・テクノロジーズ・インク Cyanophenoxycarboxylic acid compounds and compositions for delivering active agents
AU2001296865A1 (en) 2000-09-06 2002-03-22 Emisphere Technologies, Inc. (5-(2-hydroxy-4-chlorobenzoyl) aminovaleric acid and salts thereof and compositions containing the same for delivering active agents
MXPA03007857A (en) 2001-03-01 2004-05-24 Emisphere Tech Inc Compounds and compositions for delivering active agents.
US20030225300A1 (en) 2001-04-19 2003-12-04 Emisphere Technologies Inc. Compounds and compositions for delivering active agents
BRPI0411165A (en) 2003-05-14 2006-07-11 Emisphere Tech Inc pharmaceutical composition, dosage unit form and methods for preparing its use

Also Published As

Publication number Publication date
EP1750729A2 (en) 2007-02-14
RU2006138703A (en) 2008-06-20
NZ550894A (en) 2011-02-25
US20070224262A1 (en) 2007-09-27
AU2005240206A1 (en) 2005-11-17
US8039018B2 (en) 2011-10-18
AU2005240206B2 (en) 2011-04-07
KR20070008720A (en) 2007-01-17
BRPI0510226A (en) 2007-10-23
MXPA06012841A (en) 2007-02-15
WO2005107773A3 (en) 2006-01-05
WO2005107773A2 (en) 2005-11-17
WO2005107773A8 (en) 2006-12-21
JP2007536268A (en) 2007-12-13
CA2564866A1 (en) 2005-11-17
ECSP067050A (en) 2007-02-28
IL178846A0 (en) 2007-05-15

Similar Documents

Publication Publication Date Title
MA28774B1 (en) SOLID DOSING FORM OF WET HEPARIN
Yin et al. Polymer integrity related absorption mechanism of superporous hydrogel containing interpenetrating polymer networks for oral delivery of insulin
US10272155B2 (en) Use of polymeric materials with other substances for improved performance
US20100130426A1 (en) Compositions containing satiogens and methods of use
CA2561649C (en) Compressed pharmaceutical compositions comprising peg and electrolytes
MA28754B1 (en) PREPARATION OF PHARMACEUTICAL COMPOSITIONS OF INSOLUBLE DRUGS WITH RAPID DIFFUSION WATER AND PHARMACEUTICAL COMPOSITIONS THUS PREPARED
Sharma et al. Biodegradable in situ gelling system for subcutaneous administration of ellagic acid and ellagic acid loaded nanoparticles: evaluation of their antioxidant potential against cyclosporine induced nephrotoxicity in rats
WO2007044906A3 (en) Compositions and methods for enhanced gastrointestinal stability of oligopeptides and polypeptides
EP1992336A3 (en) Dosage form for the administration of active agents in the colon
WO2004080401A3 (en) Oral insulin therapies and protocol
EP2609950A3 (en) Medical device for administering a solution
Bernkop-Schnürch et al. Thiomers: The next generation of mucoadhesive polymers
Gomez-Rubio et al. Intestinal endometriosis as a cause of chronic abdominal pain leading to intestinal obstruction.
Feriani et al. Peritoneal dialysis solutions and systems
KR970064597A (en) Composition for rectal administration of drugs with gastrointestinal disorders or gastric acid degradation
WO2020008442A3 (en) Biopharmaceutical agents for use in reducing lipid content in cells
CA2551043A1 (en) The use of cystine or cysteine for the prevention and treatment of oxidative stress caused by haemodialysis and of acute or chronic kidney diseases
Kim et al. Leukocytoclastic Vasculitis Associated with Ulcerative Colitis
WO2003037296A3 (en) Methods and dosage forms for improving the bioavailability of therapeutic agents
Harijanti et al. Candidosis on oral lichen planus
Akimoto Acute interstitial nephritis: case report
JOHKO et al. CHRONIC IDIOPATHIC COLONIC PSEUDO-OBSTRUCTION IMPROVED BY LAPAROSCOPY-ASSISTED SIGMOIDECTOMY
Dhia et al. Insuffisance rénale aiguė aux antibiotiques
Morelle Diclofenac/tenofovir disoproxil fumarate interaction
Denis-Thely et al. P161-Miliaire sudorale pas toujours anodine!