KR880001623A - Process for preparing nitrogen-containing heterocyclic compound - Google Patents

Abstract

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Description

Process for preparing nitrogen-containing heterocyclic compound

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Claims (5)

Preparation of the nitrogen-containing heterocyclic compound of the following formula (A) characterized by halogenating the compound of the formula (A) obtained by etherifying the compound of the following formula (I) with the compound of the following formula (II). Way. M and m 'in the formula (A) are each 0 or 1; n is 0, 1 or 2; W is oxygen, sulfur NR ⁴ or carbonyl; W 'is oxygen, sulfur, NR ⁴ , carbonyl, sulfinyl or sulfonyl; X is oxygen or sulfur; Z is hydrogen, C _1-8 alkyl, C _1-8 haloalkyl or halogen; R is C _3-8 alkyl, C _2-8 alkenyl, _2-8 alkynyl, C _1-8 haloalkyl, C _2-8 haloalkenyl, C _2-8 haloalkynyl, C _2-10 alkoxyalkyl , C _2-10 alkylthioalkyl, C _3-8 cycloalkyl, C _3-8 halocycloalkyl, C _4-12 cycloalkyl or hetero cycloalkyl; Each of R ¹ and R ^{4 is} hydrogen or C _1-8 alkyl; R ² is hydrogen, C _1-8 alkyl or halogen; R ³ is an aromatic nitrogen-containing heteroring selected from pyridyl, 3-pyridazinyl, 2-pyrimidinyl, pyridinyl, triazinyl, or 2-thiazolyl and the like (this hetero ring is halogen, C _1-8 alkyl, C _May be unsubstituted or substituted by one or more substituents selected from _1-8 haloalkyl, C _1-8 alkoxy, C _1-8 alkylthio, NO ₂ and the like), or k is 0 or 1 May be a (G ₁ ) group; (k is 0 degrees 1 and each of R ₁₆ , R ₁₇ , R ₁₈ , and R ₁₉ is hydrogen or methyl); In Formula (I), R, R ₁ , R ₂ , W ', W, Z, m, m' and n are as defined above and Q1 is OH, SH or a free group which can be separated under reaction conditions, R ³ in formula (II) is as defined above and Q ₂ is a free group which can be separated under reaction conditions where Q ₁ is OH or SH or Q ₁ is free group OH or SH. The process of claim 1, wherein R is C _3-6 alkyl or C _3-6 alkenyl. The N-containing heteroring according to claim 1 or 2, wherein R ₃ is selected from 2-pyridyl, 2-pyrimidinyl, 1,3-thiazol-2-yl (heteroring is unsubstituted or Mono-substituted by halogen) or 2-thiazolin-2-yl. 4. The method of claim 3 wherein m and m 'are 1 and n is 0. 5. The method of claim 4, wherein Z is hydrogen, W is oxygen, W 'is oxygen or sulfur, R ¹ is hydrogen or methyl and R ² is hydrogen, methyl or halogen. ※ Note: The disclosure is based on the initial application.