KR20220148823A - Poxvirus-based vectors produced by natural or synthetic DNA and uses thereof - Google Patents

Abstract

Disclosed is a method for producing a poxvirus-based vector or a recombinant poxvirus-based vector from a naturally derived, chemically synthesized DNA fragment, or a combination of naturally derived and chemically synthesized DNA fragments. One or more DNA sequences or other heterologous gene sequences encoding one or more antigens, subunits or fragments thereof are inserted at one or more poxvirus insertion sites in the one or more DNA fragments. The method comprises reconstituting a poxvirus or recombinant poxvirus in the host cell and transfecting the host cell with one or more circular or linear DNA fragments such that the reconstituted poxvirus or recombinant poxvirus comprises the genome of the desired poxvirus. . Also disclosed are poxviruses or recombinant poxviruses produced by the technology and uses thereof.

Description

Poxvirus-based vectors produced by natural or synthetic DNA and uses thereof

claim priority

This application claims priority to U.S. Provisional Patent Application No. 62/969,628, filed on February 3, 2020, and U.S. Provisional Patent Application No. 63/113,803, filed on November 13, 2020, the contents of which are herein incorporated by reference in their entirety. incorporated by reference.

sequence list

This application has been filed electronically in ASCII format and contains a Sequence Listing, which is incorporated herein by reference in its entirety. Said ASCII copy, created on February 2, 2021, is named 8200WO00_SequenceListing.txt and is 652 kilobytes in size.

Poxviruses are large double-stranded, enveloped DNA viruses that fully replicate in the cytoplasm of infected cells by encoding their own enzymes for DNA transcription and replication ^20,27 . One of the greatest achievements in medical history has been the eradication of the causative agent of smallpox (Variola virus) by herd vaccination with a replication-competent, attenuated Vaccinia virus vaccine strain. Vaccinia virus has been used as a prototype member to study poxvirus replication and has been further developed to generate recombinant vaccines and oncolytic agents.

Modified Vaccinia Ankara (MVA) is a highly attenuated orthopox derived from its parent strain Chorioallantois Vaccinia Ankara (CVA) by passage 570 on chicken embryonic fibroblasts (CEF). It is an orthopoxvirus ¹ . As a result of the attenuation process, MVA acquired six major genomic deletions (Del1-6) as well as a number of shorter deletions, insertions, and point mutations, resulting in gene fragmentation, truncations, short internal deletions, and amino acid substitutions. ² . Although all of these mutations likely contribute to the highly attenuated phenotype of MVA, the precise genetic determinants associated with MVA assembly deficiency remain unclear ^2,3 . MVA severely limited host cell tropism, which allowed for productive assembly only in avian cells, e.g., CEF and baby hamster kidney (BHK) cells, whereas in humans and most other mammalian cells, MVA assembly is highly resistant to viruses. ^4,5 It is interrupted due to late blockage of assembly. Although non-pathogenic and highly attenuated, MVA retains good immunogenicity as demonstrated in various animal models and humans ^6,7 . In the later stages of the smallpox eradication campaign, MVA was used as a priming vector for a replication competent vaccinia-based vaccine in more than 120,000 individuals in Germany and no adverse events were reported ⁸ . Over the past few decades, MVA has been developed as a standalone smallpox vaccine and is currently pursued by the US government as a safer alternative to replace the existing vaccinia-based vaccine stock as a preventive measure in case of smallpox outbreaks ^9-11 . The FDA approved MVA under the trade name Jynneos (Bavarian Nordic) on September 24, 2019 to prevent both smallpox and monkey smallpox. Previously, the same MVA vaccine using the trade name Imvamune was approved as a smallpox vaccine in Europe.

All MVA vectors or derivatives thereof currently used are licensed or owned by academic, commercial, or government agencies, which greatly limits their use to develop MVA-based vaccine vectors. Therefore, there is a need to develop alternative MVA vectors for various research, prophylactic, and therapeutic uses. In addition, new technologies are urgently needed to accelerate the development of recombinant poxvirus vectors for pathogen preparation and disease prevention.

In one aspect, the present disclosure relates to a poxvirus vector or a method of producing a recombinant poxvirus vector. The method involves transfecting one or more DNA fragments into a host cell, wherein the one or more DNA fragments comprise the entire genomic DNA sequence of a poxvirus of interest such that the poxvirus is reconstituted in the host cell. In certain embodiments, two or more DNA fragments are co-transfected into a host cell, each DNA fragment being sequentially assembled by homologous recombination when the two or more DNA fragments are reconstituted in the host cell to form a fragment of the poxvirus genome. contains a partial sequence of the poxvirus genome to include the full-length sequence. In certain embodiments, the method further involves infecting a host cell with a helper virus prior to, during, or after transfection of the one or more DNA fragments to initiate transcription of the one or more DNA fragments. In certain embodiments, the helper virus is Fowl pox virus (FPV), sheep fibroma virus, vaccinia virus, or vaccinia virus. In certain embodiments, one or more DNA fragments are circularized or transfected into a host cell in circular form prior to transfection. In certain embodiments, one or more DNA fragments are cloned into a plasmid or bacterial artificial chromosome (BAC) vector. In certain embodiments, one or more DNA fragments are linearized or transfected into a host cell in a linearized form prior to co-transfection. In certain embodiments, the one or more DNA fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments. In certain embodiments, the poxvirus genomic sequence comprises the sequence of modified vaccinia ankara (MVA) accession number #U94848 or #AY603355. In certain embodiments, the poxvirus genomic sequence comprises a sequence of a vaccinia virus genome. In certain embodiments, two adjacent DNA fragments have overlapping sequences that facilitate homologous recombination. In certain embodiments, the overlapping sequence is from about 100 bp to about 5000 bp in length. In certain embodiments, the one or more DNA fragments further comprise an inverted terminal repeat (ITR) region. In certain embodiments, the one or more DNA fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genomic degradation (CR) sequence, or both, wherein the HL or CR sequence is single-stranded in a sense or antisense orientation. or added to one or both ends of the DNA fragment as a double-stranded DNA sequence. In certain embodiments, the one or more DNA fragments further comprise one or more HL sequences and one or more CR sequences. In certain embodiments, each HL sequence is flanked by two CR sequences at both ends of the HL sequence. In certain embodiments, only a subset of one or more DNA fragments comprises an HL or CR sequence. In certain embodiments, the one or more DNA fragments further comprise one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof. In certain embodiments, the two or more DNA fragments comprise DNA sequences of the same antigen, subunits or fragments thereof, or identical heterologous DNA sequences. In certain embodiments, the two or more DNA fragments comprise DNA sequences of different antigens, subunits or fragments thereof, or other heterologous DNA sequences. In certain embodiments, the DNA sequence or other heterologous DNA sequence of the antigen, subunit or fragment thereof, is codon optimized for expression in a host cell. In certain embodiments, the one or more DNA fragments comprise a viral promoter upstream of the antigen, a DNA sequence of a subunit or fragment thereof or other heterologous DNA sequence, a DNA sequence of the antigen, a subunit or fragment thereof, or other heterologous DNA sequence downstream of a transcription termination signal; or both. In certain embodiments, a DNA sequence or other heterologous DNA sequence encoding an antigen, subunit or fragment thereof, is inserted at one or more poxvirus insertion sites such as intergenic regions, non-essential genes and regions, and deletion sites.

In another aspect, (i) a single DNA fragment, or two or more DNA fragments, comprising the entire genome of a poxvirus of interest, when delivered to a host cell upon co-transfection, assembles sequentially to form the poxvirus genome two or more DNA fragments comprising the full-length sequence and each comprising a partial sequence of the genome of the desired poxvirus to enable reconstitution of the poxvirus, and (ii) one or more antigens inserted at one or more insertion sites of the poxvirus , one or more DNA sequences or other heterologous DNA sequences encoding subunits or fragments thereof, wherein the antigen or subunits or other heterologous DNA sequences are present in a host cell upon transfection of the one or more poxvirus DNA fragments and reconstitution of the poxviruses. Disclosed herein is an expression system comprising a DNA sequence that is to be expressed. In certain embodiments, one or more DNA fragments are circularized or transfected into a host cell in circular form prior to transfection. In certain embodiments, one or more DNA fragments are cloned into a plasmid or BAC vector. In certain embodiments, one or more DNA fragments are linearized or transfected into a host cell in a linearized form prior to transfection. In certain embodiments, the one or more DNA fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments. In certain embodiments, the genomic sequence of the poxvirus comprises the sequence of MVA accession number #U94848 or #AY603355. In certain embodiments, two adjacent DNA fragments have overlapping sequences that facilitate homologous recombination. In certain embodiments, the overlapping sequence is from about 100 bp to about 5000 bp in length. In certain embodiments, the one or more DNA fragments further comprise an inverted terminal repeat (ITR) region. In certain embodiments, the one or more DNA fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genomic degradation (CR) sequence, or both, wherein the HL or CR sequence is single-stranded in a sense or antisense orientation. or added to one or both ends of the DNA fragment as a double-stranded DNA sequence. In certain embodiments, the one or more DNA fragments further comprise one or more HL sequences and one or more CR sequences. In certain embodiments, each HL sequence is flanked by two CR sequences at both ends of the HL sequence. In certain embodiments, only a subset of one or more DNA fragments comprises an HL or CR sequence. In certain embodiments, the one or more DNA fragments comprise a DNA sequence encoding an antigen, a subunit or fragment thereof, or another heterologous DNA sequence upstream of a viral promoter, a DNA sequence encoding an antigen, a subunit or fragment thereof, or other heterologous DNA sequence. downstream of a transcription termination signal, or both. In certain embodiments, a DNA sequence or other heterologous DNA sequence encoding one or more antigens, subunits or fragments thereof is inserted at one or more poxvirus insertion sites.

In another aspect, (i) a single DNA fragment, or two or more DNA fragments, comprising the entire genome of a poxvirus of interest, when delivered to a host cell upon co-transfection, assembles sequentially to form the poxvirus genome two or more DNA fragments comprising the full-length sequence and each comprising a partial sequence of the genome of the desired poxvirus to enable reconstitution of the poxvirus, and (ii) one or more antigens inserted at one or more insertion sites of the poxvirus , one or more DNA sequences or other heterologous DNA sequences encoding subunits or fragments thereof, wherein the antigen, subunits or fragments thereof or other heterologous DNA sequences are present in a host cell upon transfection of the one or more DNA fragments and reconstitution of the poxvirus. Disclosed herein is a vaccine composition for preventing or treating cancer or an infectious disease comprising a DNA sequence that is expressed. In certain embodiments, the antigen, subunit or fragment thereof or other heterologous DNA sequence is inserted at one or more poxvirus insertion sites. In certain embodiments, the vaccine composition further comprises a pharmaceutically acceptable carrier, adjuvant, additive, or combination thereof.

In another aspect, disclosed herein is a method of preventing or treating a cancer or viral infection in a subject comprising administering to the subject a prophylactically or therapeutically effective amount of a vaccine composition, wherein the vaccine comprises (i) the poxvirus of interest When a single DNA fragment, or two or more DNA fragments, comprising the entire genome of two or more DNA fragments, each comprising a partial sequence of the genome of the poxvirus desired to cause, and (ii) one or more DNA encoding one or more antigens, subunits or fragments thereof inserted into one or more insertion sites of the poxvirus sequence or other heterologous DNA sequence, wherein the antigen, subunit or fragment thereof or other heterologous DNA sequence is expressed in a host cell upon transfection of one or more DNA fragments and reconstitution of a poxvirus. In certain embodiments, the antigen, subunit or fragment thereof or other heterologous DNA sequence is inserted at one or more poxvirus insertion sites.

This application contains at least one drawing made in color. Copies of this application with color drawings will be provided by the Office upon request and payment of the necessary fees.
1A-1C present schematics of sMVA construction. 1A: Schematic of the MVA genome. The MVA genome is approximately 178 kbp long and contains an internal native region (UR) flanked by inverted terminal repeats (ITRs) of large ˜9.6 kbp length. 1B: Schematic of the sMVA fragment. Each of the three sMVA fragments is approximately 60 kbp in length. sMVA fragment 1 (F1) contains the sequence of the left portion of the MVA genome including the left ITR; sMVA fragment 2 (F2) contains the sequence of the middle portion of the MVA genome; sMVA fragment 3 (F3) contains the sequence of the right portion of the MVA genome including the right ITR. sMVA F1 and F2 as well as sMVA F2 and F3 share a ~3 kbp overlapping sequence (crossed dotted lines) for homologous recombination. Common, including Del2, IGR44/45 (44/45), and IGR64/65 (69/70) in sMVA F1, IGR69/70 (69/70) and TK insertion sites in sMVA F2, and Del3 in sMVA F3 The approximate location of the MVA insertion site used as 1C: Schematic of terminal HL and CR sequences. Each sMVA fragment contains a sequence composition comprising duplex copies of the MVA terminal HL and flanking CR sequences at both ends to facilitate genomic digestion and packaging. SfiI and Fsel restriction sites at both ends of each sMVA fragment as shown to release the fragment from the bacterial vector backbone (pCCI-Brick) with or without terminal CR/HL/CR sequences by enzymatic digestion Included.
Figure 2 presents the reconstruction of sMVA. A schematic for the generation of sMVA (sMVA) using three sMVA fragments (F1-F3) as shown in FIG. 1 is shown. The three sMVA fragments are from E. It is stably maintained in E. coli and then isolated from the bacteria and transferred to MVA-permissive BHK or CEF cells as circular or linearized DNA molecules by transfection. Transfected cells are subsequently infected with fowlpox virus (FPV) as a helper virus to initiate MVA genome transcription and replication and consequently reconstitution of sMVA in its viral form.
3 depicts the construction of recombinant sMVA with one antigen. A schematic is presented for an example of construction of recombinant sMVA (rsMVA) with one introduced antigen sequence, heterologous gene sequence, or other genomic alteration. Antigen or heterologous gene sequences (black circles) are either linear PCR-derived products or other types of linear DNA constructs using E. It is inserted into the MVA genomic sequence of F2 (or one of the other sMVA fragments (F1 or F3)) by bacterial recombination methods in E. coli. The modified sMVA fragment F1 and the unmodified sMVA fragment F2 and F3 are E. E. coli isolated and co-transfected with FPV-infected BHK or CEF cells in circular or linearized form to initiate reconstitution of rsMVA expressing one antigen or heterologous gene sequence. Nucl. = cell nucleus.
Figure 4 illustrates the construction of recombinant sMVA with three antigens. A schematic is presented for an example of the generation of recombinant sMVA (rsMVA) with three introduced antigen sequences, heterologous gene sequences, or other genomic alterations. Antigen or heterologous gene sequences (shown as squares, circles, or rectangles) can be generated using linear PCR-derived products or other types of linear DNA constructs. It is inserted into each of the three sMVA fragments (F1-F3) by bacterial recombination in E. coli. The modified F1, F2, and F3 sMVA fragments are from E. E. coli and co-transfected into permissive BHK or CEF cells in circular or linearized form, wherein the rsMVA virus expressing three antigens or heterologous gene sequences is reconstituted in the presence of FPV as a helper virus. Nucl. = cell nucleus.
5 illustrates the sMVA reconstruction process. A schematic is presented for an example of a tissue culture reconstitution process of sMVA or rsMVA using three sMVA fragments (F1-F3) or modified forms thereof. BHK cells seeded in a 6-well tissue culture format were co-transfected with three sMVA fragments (unmodified, modified, or a combination thereof) and subsequently infected with FPV as a helper virus to induce transcription of the sMVA fragment and replication and, consequently, reconstitution of the sMVA virus. Transfected/infected BHK cells are transferred to a larger tissue culture format every other day (at 2, 4, and 6 days post-transfection/infection (dpt/i)) to facilitate sMVA reconstitution as indicated. Plaque development and progression can be detected after day 2 and day 4 cell migration, resulting in 90-100% infected BHK cells at 7 or 8 dpt/i after day 6 migration.
6A-6B present the sMVA infectivity assay. 6A is a plaque assay showing representative brightfield microscopy images of five individual plaques of BHK cell monolayers infected with either sMVA or MVA NIH clone 1 at 1 day post-infection (dpi). 6B shows the progression of infection. Representative bright field microscopy images of BHK cell monolayers infected with sMVA or MVA NIH clone 1 at 1, 2, and 3 dpi are shown. Mock-infected (uninfected) BHK cell monolayers were analyzed as controls. Plaques and infected areas were visualized by immunostaining for vaccinia virus B5R protein.
7A-7L show PCR analysis of reconstituted sMVA. BHK cells were infected with three sMVA fragments (F1-F3) or sMVA virus reconstituted from MVA NIH clone 1 at MOI 5 and DNA extracted from infected BHK cells was evaluated by PCR. DNA extracted from mock-infected (uninfected) BHK cells (BHK) as well as H ₂ O alone (Ctrl) were analyzed for control. PCR analysis showed inverted terminal repeats (ITRs) ( FIG. 7A ); Transition from left ITR to internal native region (LITR/UR) ( FIG. 7B ) and MVA deletion 2 site (Del2) ( FIG. 7C ), located in sMVA F1-derived DNA; Intergenic region (IGR) between MVA 69R and 70L located in sMVA F2-derived DNA (IGR69/70) ( FIG. 7D ); located in sMVA F3-derived DNA, MVA deletion 3 site (Del3) ( FIG. 7E ) and internal UR to right ITR transition (UR/RITR) ( FIG. 7F ); reconstitution of recombination sites of sMVA F1 and F2 (F1/F2) (FIG. 7G) as well as F2 and F3 (F2/F3) (FIG. 7H); and sequence detection of MVA genomic locations ( FIGS. 7I-7L ) containing five nucleotide polymorphisms (Polym. 1, 2, 3, 4/5) specific for the MVA strain Antoine. Prospective PCR products are indicated on the right side of each panel by arrows. Expected sizes of PCR products are provided in parentheses below each panel.
Figure 8 presents the reconstruction of sMVA using a single fluorescent marker. At 6 and 7 days (dpt/i) post-transfection/infection with unmodified sMVA fragments F1 and F3 and modified sMVA fragment F2 (F2-RFP) with inserted red fluorescent protein (RFP) marker. Representative immunofluorescence and bright field microscopy images of BHK cell monolayers are shown. The sMVA reconstitution procedure from these fragments is illustrated in Figure 5 and FPV was used as a helper virus. Mock-transfected/infected BHK cell monolayers were analyzed as controls.
Figure 9 presents the reconstruction of sMVA using dual fluorescent markers. Unmodified sMVA fragment F1, modified sMVA fragment F2 with an inserted red fluorescent protein (RFP) marker (F2-RFP), and modified sMVA fragment F3 with an inserted blue fluorescent protein (BFP) marker (F3-BFP) ) are shown representative immunofluorescence and brightfield microscopy images of BHK cell monolayers at 6 and 7 days post-transfection/infection (dpt/i). The sMVA reconstitution procedure from these fragments is illustrated in Figure 5 and FPV was used as a helper virus. Mock-transfected/infected BHK cell monolayers were analyzed as controls.
10A-10H illustrate various examples of rsMVA HCMV vector construction. Inserted HCMV antigen sequence based on the 5 subunits of the pentameric complex (PC; including UL128, UL130, UL131A, gH, and gL), glycoprotein B (gB), phosphoprotein 65 (pp65), and/or An example is given of the use of the sMVA fragment F1-F3 to generate an rsMVA vector with very early proteins 1 and 2 (IE1 and IE2). The HCMV antigen sequences were individually or combined into 2A-linked polycistronic expression constructs as indicated, resulting in MVA deletion 3 (Del3) sites or open reading frames 044/045 (44/45), 064/065 (64/65) , or different MVA insertion sites containing the intergenic region between 069/070 (69/70). all PC subunits (sMVA-PC1 (FIG. 10A) and sMVA-PC2 (FIG. 10B)), along with gB and pp65 all PC subunits (sMVA-7Ag1 (FIG. 10C) and sMVA-7Ag2 (FIG. 10D)), or Examples are provided for rsMVA vectors expressing all PC subunits, gB, and pp65 (sMVA-8Ag1/2 ( FIGS. 10E-10F )) and sMVA-9Ag2 ( FIGS. 10G-10H ) with IE1/IE2 antigens. mH5 denotes a vaccinia modified H5 promoter and ITR denotes an inverted terminal repeat.
11A-11B present sMVA characterization. 11A: PCR analysis. CEFs infected with sMVA derived from FPV HP1.441 (sMVA hp) or TROVAC from two independent viral reconstitutions (sMVA tv1 and sMVA tv2) were identified by PCR at multiple MVA genomic locations (ITR sequence, left to internal native region). or right ITR transitions (left ITR/UR; UR/right ITR), Del2, IGR69/70 and Del3 insertion sites, and F1/F2 and F2/F3 recombination sites, and absence of BAC vector sequences. PCR reactions using wtMVA-infected and uninfected cells, no samples (mock), or using MVA BAC were performed as controls. 11B: Restriction fragment length analysis. Viral DNA isolated from ultra-purified sMVA (sMVA tv1 and sMVA tv2) or wtMVA virus was compared by KpnI and XhoI restriction enzyme digestion.
12A-12D present sMVA replication characteristics. The replication properties of sMVA (sMVA hp) derived from FPV HP1.441 or TROVAC (sMVA tv1 and sMVA tv2) from two independent sMVA virus reconstitutions were compared with wtMVA. 12A: Virus focus. CEFs infected with sMVA virus or wtMVA reconstituted at low multiplicity of infection (MOI) were immunostained using anti-vaccinia polyclonal antibody (αVAC). 12B: Replication rate. BHK or CEF cells were infected with sMVA or wtMVA at an MOI of 0.02 and the viral titers of inoculum and infected cells at 24 and 48 hours post infection were determined on CEF. A mixed-effect model using Geisser-Greenhouse corrections was applied; Differences between groups at 24 and 48 hours post infection were not significant. 12C: Virus focus size analysis. BHK or CEF cell monolayers were infected with sMVA or wtMVA at an MOI of 0.002 and the area of viral foci was determined after immunostaining with αVAC antibody 24 hours after infection. 12D: Host cell coverage analysis. Various human cell lines (HEK293, A549, 143b, and HeLa), CEF or BHK cells were infected with sMVA or wtMVA at an MOI of 0.01 and virus titers were determined on CEFs 48 h post infection. The dotted line represents the calculated viral titer of the inoculum based on an MOI of 0.01. Differences between groups in Figures 12C-12D were calculated using one-way ANOVA followed by Tukey (2C) or Dunnett (2D) multiple comparison tests. ns = not significant.
13A-13D demonstrate sMVA in vivo immunogenicity. sMVA derived from FPV HP1.441 (sMVA hp) or TROVAC (sMVA tv1 and sMVA tv2) from two independent viral reconstitutions were compared to wtMVA by in vitro assays. C57BL/6 mice were immunized twice with low (1×10 ⁷ PFU) or high (5×10 ⁷ PFU) doses of sMVA or wtMVA at 3-week intervals. Mock-immunized mice were used as controls. Figure 13A: Binding antibody. MVA-specific binding antibodies (IgG titers) stimulated by sMVA or wtMVA were measured by ELISA after the first and second immunizations. Figure 13B: NAb reaction. MVA-specific NAb titers induced by sMVA or wtMVA were measured against recombinant wtMVA expressing GFP markers after booster immunization. 13C-13D: T cell response. After two immunizations, MVA-specific IFNγ, TNFα, IL-4, and IL-10-secreting CD8+ (13C) and CD4+ (13D) T cell responses induced by sMVA or wtMVA were compared with B8R immunodominant peptides. Measured by flow cytometry after ex vivo antigen stimulation. Differences between groups were assessed using one-way ANOVA using the Turkish multiple comparison test. ns = not significant.
14A-14D demonstrate sMVA immunogenicity in vivo. sMVA derived from FPV strain HP1.441 (sMVA hp) or FPV strain TROVAC (sMVA tv1 and sMVA tv2) from two independent viral reconstitutions were compared to wtMVA by in vitro assays. C57BL/6 mice (N=4) were immunized twice with low (1×10 ⁷ PFU) or high (5×10 ⁷ PFU) doses of sMVA or wtMVA at 3-week intervals. Mock-immunized mice were used as controls. 14A: Binding antibody. The absorbance at 450 nm at different serum dilutions of the MVA-specific binding antibody (IgG titer) measured by ELISA after the first and second immunizations in mice receiving either sMVA or wtMVA is shown. 14B: NAb reaction. MVA-specific NAb titers induced by sMVA or wtMVA were measured against wtMVA expressing GFP markers after booster immunization. The measured GFP area (forward pixels (pix ² ×10 ³ )) of infected cells at different serum dilutions is shown. 14C-14D: T cell response. MVA-specific CD8+ (14C) and CD4+ (14D) T cells expressing IFNγ, TNFα, IL-4, and IL-10 in vivo with vaccinia A19L immunodominant peptide after two immunizations with sMVA or wtMVA It was measured by flow cytometry after exogenous antigen stimulation. Differences between groups were assessed using one-way ANOVA using the Turkish multiple comparison test. ns = not significant.

Disclosed herein are methods for producing poxvirus-based vectors and recombinant poxvirus vectors from circularized or linearized, naturally derived or chemically synthesized DNA. Specific examples are provided for producing fully synthetic versions of MVA (sMVA) from circularized synthetic DNA fragments as well as recombinant sMVA (rsMVA) expressing one or more heterologous gene sequences comprising fluorescent markers or infectious disease and cancer antigens.

Because of its versatile expression system and large ability to accommodate foreign DNA sequences (up to 30 kbp), in addition to its excellent stability profile ¹ , MVA is widely used to develop recombinant vaccine vectors against infectious diseases and cancer ^7,12,13 . MVA is a versatile vaccine to prevent human cytomegalovirus (HCMV) infection, a common cause of permanent birth defects in newborns and complications in transplant recipients ¹⁹ as well as different vaccine strategies ^14,15 for the treatment of cancer. Approaches ^16-18 have been sought to develop. Some of these vaccines have completed Phase I or II clinical evaluation ^14,17 . As a member of the poxvirus family, MVA replicates fully in the cytoplasm of infected cells, providing its own enzymes for transcription and DNA replication ^1,20 . Although MVA virus production is halted due to a late blockade of assembly in mammalian cells, MVA can efficiently infect most mammalian cells, including human cells, and initiate robust gene expression and DNA replication, which causes MVA to bind to foreign antigens. This makes it an ideal vehicle for efficient in vitro and in vivo delivery and expression of ^1,5 . The most commonly used method for generating MVA recombinants is the use of a transfer plasmid that is co-delivered into permissive cells (CEF or BHK) with MVA, whereby the desired antigen along with an upstream promoter sequence and a downstream transcription termination signal is spontaneously transferred. It is based on the so-called transfection/infection method, which inserts into the MVA genome by homologous recombination ^1,5,21 .

Although this method is widely used, it can be difficult and hampered by several rounds of selection during antigen insertion and additionally during subsequent marker removal to obtain a homogeneous population of recombinant MVA ²¹ . These problems with conventional transfection/infection methods can be particularly problematic for the generation of multiantigen MVA vectors with antigens inserted into two or more insertion sites, which can reduce MVA vaccine stability ^18,22 . As an alternative to conventional transfection/infection methods and to facilitate the production of multiantigen MVA vectors, methods for generating MVA recombinants using bacterial artificial chromosome (BAC) technology have been developed ^23-25 . These methods allow repeated manipulations to insert antigen into the MVA genome by a highly efficient and versatile mutagenesis technique and the helpers required to "jump-start" the transcription of the non-infectious MVA genome in BHK cells. The use of fowlpox virus (FPV) as a virus allows reconstitution of a homogeneous viral population of recombinant MVA ²³ .

Construction of synthetic poxviruses

Disclosed herein are methods of producing poxvirus-based vectors or recombinant poxvirus vectors from naturally derived or chemically synthesized DNA. In certain embodiments, a single DNA fragment is derived from or chemically synthesized from viral DNA and comprises the entire genome sequence of a poxvirus. This single DNA fragment can be used to transfect host cells such that the poxvirus is reconstituted. In other embodiments, two or more naturally derived or chemically synthesized DNA fragments, or a combination thereof, are used to co-transfect a host cell, wherein each DNA fragment comprises two or more DNA fragments. When co-transfected into this host cell, a pox having overlapping sequences at the ends of two adjacent DNA fragments such that they assemble together by homologous recombination to form a poxvirus comprising the full-length sequence of the desired poxvirus genome. Contains a partial sequence of viral genomic DNA. In certain embodiments, the overlapping sequence is from about 100 bp to about 5000 bp in length.

In certain embodiments, a shortened genomic sequence other than the whole genomic sequence or an altered genomic sequence having deletion(s) or modification(s) in a non-essential gene or region of the genomic sequence of a poxvirus, or two or more different pox Hybrid derivatives comprising genomic sequences from viruses can be used to produce the vectors disclosed herein.

In certain embodiments, one or more naturally-derived or chemically synthesized DNA fragment(s) comprising poxvirus genomic or subgenomic DNA is further modified to form an artificial hybrid composed of natural and synthetic poxvirus genomic DNA sequences. fragments can be formed. In other embodiments, one or more naturally derived or chemically synthesized DNA fragment(s) may be composed of sequences derived from two different poxviruses to form a poxvirus hybrid sequence. The one or more DNA fragment(s) is a poxvirus sequence or MVA (NCBI accession #U94848, #AY603355), vaccinia virus (#NC_006998, #LT966077), Camelpox virus (#NC_003391), vaccinia virus (# NC_003663) Ectromelia virus (#NC_004105), monkey smallpox virus (#NC_003310), Racoonpox virus (#NC_027213), Skunkpox virus (#NC_031038), taterapox Taterapox virus (#NC_008291), Variola virus (#NC_001611, #L22579), Velopox virus (#NC_031033), Canarypox virus (#NC_005309), Swinepox virus ) (#NC_003389), FPV (#NC_002188, #MH734528), Myxoma virus (#GQ409969), Sheeppox virus (NC_004002), Goatpox virus (#NC_004003), (Orff Virus (Orf virus #NC_005336), Rabbit fibroma virus (#NC_001266), any strain variant of these poxviruses, or any other poxvirus or strain variants thereof, consisting of different poxvirus sequences derived from It may consist of a sequence.

In certain embodiments, the host cell is infected with a helper virus such as FPV prior to, during, or after transfection of one or more DNA fragments comprising sequences of poxvirus genomic or subgenomic DNA. The helper virus may be any suitable virus that infects a host cell and allows the initiation of transcription and replication of the poxvirus. FPV that does not undergo homologous recombination with poxvirus DNA in a host cell is used herein as an example. Helper viruses cannot replicate in host cells. Moreover, a helper virus, eg FPV for the purposes of the present application, is not itself a component of the reconstituted poxvirus. In certain embodiments, vaccinia virus, Shope fibroma virus, or other suitable poxvirus may be used as the helper virus. In certain embodiments, one or more DNA fragments for transfection may be linearized, circularized, or a combination of linearized and circularized DNA fragments. In certain embodiments, one or more DNA fragments for transfection are cloned into a vector such as a plasmid or BAC and/or a host cell such as a bacterial cell, eg, E. maintained in coli.

In certain embodiments, the one or more DNA fragment(s) further comprise one or both inverted terminal repeat (ITR) regions of a poxvirus. In certain embodiments, the sequence of the ITR may contain one or more alterations or mutations that do not affect the design scheme of the reconstituted poxvirus. In one embodiment, the one or more DNA fragments that reconstitute the poxvirus may contain only a portion of the ITR sequence. For example, sMVA fragments F1 and F3 as well as reconstituted sMVA vectors or recombinant sMVA vectors ( FIGS. 1-4 ) may contain only a portion of the MVA ITR sequence. In certain embodiments, one or more DNA fragment(s) are further modified to one or both ends as a duplex copy (double-stranded DNA) or at the 5' and/or 3' ends as a single-stranded nucleotide sequence to the poxvirus Add the terminal hairpin loop (HL) sequence. For example, an HL sequence can be added to one or both ends of a synthetic DNA fragment as a double-stranded or single-stranded DNA sequence in either sense (5' to 3') or antisense (3' to 5') orientation. In certain embodiments, one or more DNA fragment(s) are further modified to digest poxvirus concatemers at one or both ends as a double-stranded DNA sequence or at the 5' and/or 3' ends as a single-stranded nucleotide sequence. (CR: concatemeric resolution) sequence is added. The CR sequence may be based on any sequence derived from the consensus sequence 5'-T ₆ -N _7-9 -T/CA ₃ -T/A-3', wherein A is adenine, C is cytosine, G is guanine, T is thymine, and N is any nucleotide. In certain embodiments, two CR sequences may be added to both ends of an HL sequence to form a CR-HL-CR sequence. The CR-HL-CR sequence may be added to one or more DNA fragment(s) at one or both ends as a double-stranded DNA sequence, or at the 5' end, 3' end, or both ends as a single-stranded nucleotide sequence. . In other embodiments, only HL or CR sequences are added to one or both ends of the one or more DNA fragment(s) as double or single stranded DNA sequences. In certain embodiments, all DNA fragments contain an HL or CR sequence or a combination thereof at one or both ends. In other embodiments, not all DNA fragments contain HL or CR sequences. In certain embodiments, only a subset or subpopulation of DNA fragments contain HL or CR sequences, or a combination thereof. ITR, HL or CR sequences are MVA (NCBI accession #U94848, #AY603355), vaccinia virus (#NC_006998, #LT966077), camelpox virus (#NC_003391), vaccinia virus (#NC_003663) ectromelia virus (#NC_004105) ), monkey pox virus (#NC_003310), raccoonpox virus (#NC_027213), skunkpox virus (#NC_031038), taterapox virus (#NC_008291), variola virus (#NC_001611, #L22579), velopox virus ( #NC_031033), canarypox virus (#NC_005309), pigpox virus (#NC_003389), FPV (#NC_002188, #MH734528), myxoma virus (#GQ409969), sheeppox virus (NC_004002), goatpox virus (#NC_004003), ( Orff virus #NC_005336), rabbit fibroma virus (#NC_001266), any strain variant of these poxviruses, or any other poxvirus or strain variant thereof.

In certain embodiments, an HL or CR sequence as used herein is disclosed as follows:

The sequence of the terminal CR-HL-CR sequence (215 bp long, 5' to 3') containing a duplex copy of the MVA terminal hairpin loop (HL) flanked by the MVA concatemer cleavage sequence (SEQ ID NO: SEQ ID NO): 1) (CR sequence is underlined and HL sequence is italicized and double underlined):

Sequence of the terminal CR-HL-CR sequence (215 bp long, 5' to 3') containing a duplex copy of the complementary form of the MVA terminal hairpin loop (HL) flanked by the concatemer cleavage sequence (SEQ ID NO: 3') Number: 2) (CR sequence is underlined and HL sequence is italicized and double underlined):

Sequence of MVA terminal hairpin loop (HL, 165 nt length, 5' to 3') (SEQ ID NO: 3):

The sequence of the complementary form of the MVA terminal hairpin loop (HL, 165 nt length, 5' to 3') (SEQ ID NO: 4):

Sequence of the terminal CR-HL-CR sequence (154 bp long, 5' to 3') containing a duplex copy of the vaccinia terminal hairpin loop (HL; S-form) flanked by a concatemer cleavage sequence ( SEQ ID NO: 5) (CR sequence is underlined and HL sequence is italicized and double underlined):

The sequence of the terminal CR-HL-CR sequence (154 bp long, 5' to 3') containing a duplex copy of the vaccinia terminal hairpin loop (HL; F-form) flanked by a concatemer cleavage sequence ( SEQ ID NO: 6) (CR sequence is underlined and HL sequence is italicized and double underlined):

SEQ ID NO: 1 (HL, S-form, 104 nt length, 5' to 3') of the vaccinia virus terminal hairpin loop (SEQ ID NO: 7):

SEQ ID NO: 2 (HL, F-form, 104 nt length, 5' to 3') of the vaccinia virus terminal hairpin loop (SEQ ID NO: 8):

SEQ ID NO: 1 (CR, 20 bp length, 5' to 3') of the MVA concatemer cleavage sequence, included at the left end of the hairpin duplex copy in the example (SEQ ID NO: 9, sense orientation):

SEQ ID NO: 2 (CR, 20 bp length, 5' to 3') of the MVA concatemer cleavage sequence, included at the right end of the hairpin duplex copy in the example (SEQ ID NO: 10, antisense orientation):

As demonstrated in the examples, the sMVA and rsMVA recombinants disclosed herein are chemically synthesized from three -60 kbp long DNA fragments comprising the total 178 kbp of the MVA genome (Accession # U94848) published by Antoine and co-workers. It is generated based on synthesis ²⁶ . It contains an internal native region (UR) and a flanking inverted terminal repeat (ITR) region of ˜9.6 kbp in length, as illustrated in FIG. 1 . The MVA genome sequence published by Antoine et al. (Accession# U94848) ²⁶ , referred to herein as the MVA strain Antoine, is a licensed and commercially available National Institute of Health clone 1 MVA genome (MVA NIH clone) from 1974. 1) and the internal UR differ by exactly 5 bases, which is identical in sequence to the published genome of MVA strain Acambis (Accession # AY603355). sMVA fragment 1 (F1) contains the left ITR of the MVA genome and the left end of -50 kbp of the inner UR; sMVA fragment 2 (F2) contains an intermediate portion of -60 kbp of the internal UR of the MVA genome; sMVA fragment 3 (F3) contains the right end and right ITR of -50 kbp of the internal UR of the MVA genome ( FIG. 1 ). sMVA F1 and F2 as well as sMVA F2 and F3 were designed to share ˜3 kbp overlapping sequences, allowing reconstitution of the complete MVA genome by homologous recombination ( FIG. 1 ). Duplex copies of the 165-nucleotide long MVA terminal HL flanked by the MVA CR sequence were added to both ends of each of the three fragments to facilitate MVA genome digestion and packaging ²⁶ ( FIG. 1 ). In addition, SfiI and Fsel restriction sites are included at both ends of each of the three fragments in such a way that the fragment can be released or linearized with or without HL and CR sequences. The only exception is the HL and CR sequences in the ITR of F1 and F3 fused to the ends in the same arrangement as occurred at the junction of the MVA concatemer replication intermediate ²⁶ ( FIG. 1 ). As shown in Figure 1, three sMVA fragments with flanking HL and CR sequences as well as overlapping homologous recombination sequences were synthesized and generated using a yeast-based recombination system by Genscript Biotech. . All three sMVA fragments were cloned into a yeast shuttle vector called pCCI-Brick containing a bacterial mini-F replicon element that can be used as a BAC vector for stably propagating the three fragments with low copy number in bacteria ( Fig. 1). The sMVA fragment contains recombinantly defective DH10B or EPI300 E. It was ultimately cloned into E. coli cells.

In certain embodiments, duplex copies of HL with flanking CR sequences at both ends of each of the three MVA fragments are included - they are included only at the ends in the ITR of F1 and F3 naturally occurring in concatemer replication intermediates Contrary to that This design is based on the unique functions these sequence elements have during poxvirus DNA replication. The terminal HL in the packaged poxvirus genome joins two DNA strands at the end of the genome into a continuous polynucleotide chain, where they are incompletely base-paired and present at both ends in an AT-rich, inverted and complementary form ^{26 -29} . The poxvirus HL sequence is important for replication of the double-stranded DNA genome into a multimeric head-tail or head-head concatemer replication intermediate, where the HL sequence is present at the concatemer junction as an exact duplex copy ^30-32 . CR elements consist of highly conserved poxvirus degradation sequences and can be found at both ends of large ITRs directly adjacent to the terminal HL in the packaged genome ^26,27,33,34 . The poxvirus CR elements in the concatemer replication intermediate are present at one site of the HL duplex copy at the genomic junction, and these CR/HL/CR sequence alignments are essential for digestion of the unit-length genome and subsequent genome packaging ^{33- 36} . When circular plasmids containing poxvirus concatemer junctions consisting of HL duplex copies flanked by CR elements are transfected into poxvirus infected cells, they spontaneously degrade into linear minichromosomes with terminal HL ^{36, 37} . In certain embodiments, when transfected into a host cell, the circularized sMVA fragment is capable of immediate replication in the host cell in an origin-independent manner. It has been reported that any circular DNA molecule transfected into poxvirus infected cells replicates in an origin-independent manner and that this non-specific sequence replication is not enhanced by insertion of any viral DNA fragment ³⁸ . In other embodiments, when transfected into a host cell, the circularized sMVA fragment can be replicated by a eukaryotic or viral origin of replication inserted into a vector or MVA sequence.

The disclosed construction technique of synthetic poxviruses such as sMVA is a circular plasmid containing three synthetic MVA fragments with flanking concatemer genomic junctions (CR-HL-CR) and overlapping genomic sequences into FPV-infected BHK or CEF cells. or transfection of the DNA molecule promotes (1) transcription and replication of the three sMVA fragments, (2) digestion of the three sMVA fragments from the plasmid vector sequence, and (3) recombination of the three sMVA fragments into the full-length genome. and, ultimately, contain HL and CR sequences to result in packaging of the vector-free genome with terminal HLs into preformed viral particles ( FIGS. 1 and 2 ). These events may be initiated immediately as a result of FPV infection or they may occur in a sequential process following transcriptional initiation and replication of the three sMVA fragments. In another embodiment, the process of reconstitution of sMVA from three sMVA fragments can be initiated without FPV or other helper virus. In an alternative to this strategy of reconstituting sMVA from three MVA fragments using circular plasmids or DNA molecules, reconstitution of sMVA is also linearized using, for example, added Fsel and SfiI restriction sites as shown in Figures 1 and 2 This can be facilitated by an approach based on the three sMVA fragments in the isolated form.

Regardless of whether using a circular or linearized form of the three MVA fragments or a combination of circular and linearized forms, the ends of the fragments may or may not contain HL and CR sequences. In certain embodiments, only a subset of the fragments may contain HL and CR sequences, or they may be in a sense or antisense orientation, e.g., the MVAs of F1 and F3 where they occur naturally in putative concatemer replication intermediates. It can be appended to only one or two ends of a fragment as a single or double-stranded DNA sequence in such a way that it is only present in partial sequence. In another example, not all F1 fragments contain HL and CR sequences; Rather, F1 fragments with or without HL and CR sequences can be mixed during construction. Likewise, a subset or subpopulation of F2 or F3 fragments may contain HL and CR sequences, although not all F2 or F3 fragments are required to contain HL and CR sequences. In certain embodiments, the HL and/or CR sequences may also be chemically ligated as single or double stranded DNA sequences in the three fragments in a linearized form.

In another embodiment, an sMVA virus reconstituted from an sMVA fragment is modified by introducing insertions, deletions, or point mutations, or by insertion into one or more heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof. can These modifications or antigenic sequences can be introduced into the sMVA DNA fragment by conventional transfection/infection methods using transfer plasmids with homologous flanks that mediate homologous recombination. In certain embodiments, one or more nucleotide sequences encoding one or more antigens, subunits or fragments thereof may be codon optimized for eukaryotic or vaccinia expression. For example, an antigen, subunit or fragment thereof can be optimized for stability of transcription or expression in a host cell. alteration of four consecutive identical nucleotides (e.g. GGGG, CCCC, TTTT, AAAA) by introduction of silent point mutations that do not result in amino acid changes in the encoded protein, or adaptation of codon usage to a particular host species, Various codon optimization techniques may be used, but not limited thereto.

In another embodiment, a sMVA virus reconstituted from an sMVA fragment in a host cell such as a BHK or CEF cell can be used to generate an sMVA bacterial artificial chromosome (BAC) containing the full-length sMVA genome. The BAC vector sequence can be inserted into the sMVA genome by a transfer construct containing a BAC sequence with flanking homologous sequences that mediate homologous recombination. Circular replication intermediates with inserted BAC sequences are isolated from host cells such as BHK or CEF cells and allow stable propagation of large DNA constructs by electroporation or chemical transformation. coli cells, such as DH10B or EPI300. In another embodiment, the sMVA BAC is GS1783 E. It can be transferred into E. coli cells and manipulated by Red-recombinant techniques such as En passant mutagenesis.

In another embodiment, the sMVA fragment can be used to reconstruct the complete or full-length sMVA genome by in vitro ligation methods or by other in vitro DNA assembly methods such as Gibson or Golden Gate assembly. .

Expression of antigens or other heterologous gene sequences

The techniques disclosed herein provide a method for reconstituting a variety of antigens, its subunits or fragments, into one or more naturally derived or chemically synthesized DNA fragment(s) prior to transfection, such that upon reconstitution, a synthetic poxvirus expressing the antigen, subunits or fragments thereof is obtained. It has the flexibility to insert subunits or fragments, or other heterologous DNA sequences. These antigens, subunits or fragments thereof, are viruses such as cytomegalovirus (CMV), Epstein-Barr virus (EBV), Kaposi-Sarcoma-associated herpesvirus (KSHV). ), other herpesviruses, Zika virus, Lassa virus, Hepatitis C virus (HCV), hepatitis (HBV), Coronavirus (such as 2019-nCoV, SARS) , MERS), influenza, or any other virus, bacterium, or other form of an infectious pathogen. The antigenic sequence may also be derived from or based on a cancer-associated protein (eg, p53, retinoblastoma, neoantigen). Likewise, other heterologous gene sequences can be inserted into the naturally derived or chemically synthesized poxvirus DNA fragment(s). Such heterologous gene sequences include, but are not limited to, fluorescent markers, cDNA copies of RNA such as RNAi, shRNA, LNCRNA, miRNA, etc., interferons, cytokines, antibodies or fragments thereof, or other proteins expressed in prokaryotic or eukaryotic cells. does not In certain embodiments, the antigenic sequence or heterologous gene sequence is selected from an upstream native or synthetic poxvirus promoter (pSyn, P11, H5, mH5, P28, ATI, pHyb, p7.5) and downstream transcription termination signal (TTTTTAT) can be inserted into the sMVA fragment.

The DNA sequence of the antigen, subunit or fragment thereof, or other heterologous gene sequence may be inserted into one or more poxvirus insertion sites in one or more DNA fragment(s). Using sMVA as an example, the DNA sequence of one antigen or fragment thereof can be inserted into a single MVA insertion site located on one sMVA DNA fragment, eg, sMVA F2, prior to transfection of the host cell ( FIG. 3 ). ). In another example, the DNA sequences of two or more antigens or fragments thereof can be inserted into a single MVA insertion site located on one DNA fragment, eg, sMVA F2, prior to transfection of the host cell. These antigenic DNA sequences may be under the control of a single promoter or two or more promoters. Likewise, antigenic DNA sequences may share the same transcription termination signal or have different transcription termination signals. Nucleotide sequences encoding two or more antigens may also include the 2A sequence of picornaviruses (P2A, T2A, P2A, T2A, F2A, etc.) or by an internal ribosome entry site (IRES).

In certain embodiments, one or more DNA sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA sequences are transfected into a host cell by one or more naturally derived or chemically synthesized poxvirus DNA fragments. one or more fusion proteins consisting of a poxvirus protein with one or more antigens, subunits or fragments thereof, or other heterologous protein sequences added at the C-terminus, N-terminus, or any internal position of the poxvirus protein when inserted in frame at the 5' end, 3' end, or any internal location of one or more essential or non-essential poxvirus open reading frames (ORFs) for expression. In some embodiments, one or more DNA sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA sequences are added at the C-terminus, N-terminus, or any internal location of the poxvirus protein to one or more Picor such that expressed one or more fusion proteins consisting of a poxvirus protein together with an antigen, subunit or fragment thereof, or other heterologous protein sequence are processed ("cleaved") into individual components in the 2A linker sequence by a ribosome skipping mechanism. linked to one or more poxvirus ORFs by a navirus 2A coding sequence (P2A, F2A, T2A, etc.). In other embodiments, one or more DNA sequences encoding one or more antigens, subunits or fragments thereof, or other heterologous DNA sequences are transfected into a host cell by one or more naturally derived or chemically synthesized poxvirus DNA fragments. chimeric polycistronic expression constructs wherein one or more poxvirus proteins and one or more antigens, subunits or fragments thereof, or other heterologous protein sequences have multiple translation initiation sites at the 5' end of each ORF in the expression construct linked to one or more essential or non-essential poxvirus ORFs by an internal ribosome entry site sequence for simultaneous expression via

In certain embodiments, the DNA sequences or other heterologous gene sequences of two or more antigens, subunits or fragments thereof may be inserted into two or more MVA insertion sites that may be located on the same sMVA fragment or on different sMVA fragments. . For example, the DNA sequences of two or more antigens, subunits or fragments thereof can both be inserted at two different MVA insertion sites located on sMVA F1. In another example, the DNA sequences of two or more antigens, subunits or fragments thereof can be inserted into two different MVA insertion sites, one located on sMVA F1 and the other located on sMVA F2 ( FIG. 4 ). It is understood that the DNA sequences of the same antigen, subunits or fragments thereof may be inserted into different DNA fragments. Alternatively, upon reconstitution after transfection with different sMVA fragments, the different antigens, subunits or fragments thereof, expressed by synthetic MVA self-process into complete antigens comprising viral particles, viral complexes, or subunits or fragments thereof. The DNA sequences of different antigens, subunits or fragments thereof can be inserted so that they become self-assembled and self-assemble.

As demonstrated in the Examples, previously established methods ^16,18,24,25 for generating recombinant MVA vectors using BAC technology were adapted to generate rsMVA recombinants using three sMVA fragments. Since the three sMVA fragments were cloned into a BAC vector with a mini-F replicon, they can be stably propagated in bacteria, and as a result, they are highly efficient recombinant methods such as enzymatic mutagenesis or other E. coli. can be manipulated by E. coli-based manipulation procedures ^39,40 . Using these methods, a naturally derived or synthetic heterologous antigen sequence, along with an upstream vaccinia virus promoter and a downstream transcription termination signal, can be obtained from only one of three sMVA fragments in a parallel, contiguous, or repeated fashion to virtually every MVA genomic location. One, two, or all can be inserted ( FIGS. 3 and 4 ). These insertion sites are commonly used insertion sites such as MVA deletion 2 (Del2) site, open reading frame (ORF) intergenic region (IGR) between 44L and 45L (IGR44/45), ORF IGR between 69R and 70L ( IGR69/70), an IGR between 64L and 65L (IGR64/65), a thymidine kinase (TK) gene insertion site, or an MVA deletion 3 (Del3) site ( FIG. 1 ), or any other MVA deletion site, intergenic region, or gene insertion site (ORF number is based on MVA strain Antoine (Accession# U94848)). These methods can also be used to generate one or multiple point mutations, insertions, or deletions at one or multiple positions of one or more sMVA fragments. Then, the modified sMVA fragment was produced in E. E. coli isolated and co-transferred into BHK or CEF cells infected with helper viruses as circular or linearized DNA molecules by various transfection methods to initiate reconstitution of rsMVA with single, double, or multiple antigen insertions or genomic alterations. There are (Figures 3 and 4). In certain embodiments, rsMVA reconstitution may be initiated without the addition of a helper virus. In certain embodiments, three sMVA fragments can also be used to generate sMVAs with single or multiple antigen insertions or genomic alterations by in vitro ligation methods. In certain embodiments, one or more antigens, subunits or fragments thereof may be inserted into one or more MVA insertion sites of an sMVA fragment. In certain embodiments, one or more antigens or fragments thereof are inserted into only one sMVA fragment ( FIG. 3 ). In certain embodiments, one or more antigens or fragments thereof are inserted into two or more sMVA fragments ( FIG. 4 ). In certain embodiments, one or more antigens, subunits or fragments thereof are inserted into all sMVA fragments ( FIG. 4 ). When an antigen, subunit or fragment thereof is inserted into two or more sMVA fragments, the antigen, subunit or fragment thereof may be the same or different for different sMVA fragments. For example, one type of antigen or fragment thereof may be inserted into sMVA F1, and a different type of antigen or fragment thereof may be inserted into sMVA F2. Alternatively, antigens of the same type or fragments thereof may be inserted into sMVA F1 and F2 and antigens of the same type or fragments thereof or different types of antigens, subunits or fragments thereof may be inserted into sMVA F3.

The poxvirus vectors produced by the techniques disclosed herein can be used, for example, to generate multi-antigen vaccine vectors to stimulate multifunctional humoral and cellular immune responses against a variety of conditions such as viral infection and cancer. . As an example, the disclosed technology based on three sMVA fragments F1-F3 can be used to generate multi-antigen rsMVA vaccine vectors to stimulate multifunctional humoral and cellular immune responses against human cytomegalovirus (HCMV). It may contain immunodominant antigen sequences based on the five subunits of the HCMV pentameric complex (PC), glycoprotein B (gB), phosphoprotein 65 (pp65), and very early 1 and 2 proteins (IE1 and IE2). have. Antigen sequences were inserted into sMVA fragments either individually or in combination with 2A-linked polycistronic expression constructs at different commonly used MVA insertion sites (Del2, Del3, IGR44/45, IGR69/70, IGR64/65), Figure 6 and rsMVA vaccine vectors expressing 5, 6, 7, 8, or 9 HCMV antigens as illustrated in FIG. 10 . rsMVA vectors expressing only a single HCMV antigen or any other number or combination of the nine HCMV antigens mentioned above can also be generated. Any antigen sequence or expression construct can be inserted with an upstream mH5 promoter and a downstream transcription termination signal. These vectors can be used to stimulate an immune response to HCMV in animal models or humans.

Expression Systems and Vaccines

In accordance with embodiments described herein, an MVA expression system is provided herein. In certain embodiments, the expression system is capable of expressing one or more desired antigens, subunits or fragments thereof, or other heterologous protein sequences.

As described above, a DNA sequence encoding one or more antigens, subunits or fragments thereof may be inserted into one or more sMVA fragments such that the reconstituted sMVA simultaneously expresses the antigen, subunits and fragments thereof.

In certain embodiments, the antigen DNA sequence inserted into the sMVA fragment may be based on a native DNA sequence or may be from chemical synthesis. In other embodiments, antigenic DNA sequences may be optimized for expression and stability in expression systems.

The sMVA described herein can be part of a vaccine composition that can be used in a method of treating or preventing a viral infection or treating cancer, depending on the antigen expressed by the sMVA. A vaccine composition as described herein may comprise a therapeutically effective amount of an sMVA as described herein, further comprising a pharmaceutically acceptable carrier according to standard methods. Examples of acceptable carriers include physiologically acceptable solutions such as sterile saline and sterile buffered saline.

In some embodiments, a vaccine or pharmaceutical composition may be used in combination with a pharmaceutically effective amount of an adjuvant to enhance the prophylactic or therapeutic effect. Any immune adjuvant capable of stimulating the immune system and increasing the response to a vaccine without itself having any specific antigenic effect can be used as an adjuvant. Many immune adjuvants mimic evolutionarily conserved molecules known as pathogen-associated molecular patterns (PAMPs) and are recognized by a set of immune receptors known as Toll-like receptors (TLRs). Examples of adjuvants that may be used in accordance with embodiments described herein include Freund's complete adjuvant, Freund's incomplete adjuvant, double stranded RNA (TLR3 ligand), LPS, LPS analogs such as monophosphoryl lipid A (MPL). ) (TLR4 ligand), flagellin (TLR5 ligand), lipoproteins, lipopeptides, single-stranded RNA, single-stranded DNA, imidazoquinoline analogs (TLR7 and TLR8 ligand), CpG DNA (TLR9 ligand), Ribi jujube Vant (monophosphoryl-lipid A/trehalose dicorinoicolate), glycolipid (α-GalCer analog), unmethylated CpG island, oil emulsion, liposome, virosome, saponin (active fraction of saponin, such as QS21), muramyl dipeptides, alum, aluminum hydroxide, squalene, BCG, cytokines such as GM-CSF and IL-12, chemokines such as MIP 1-α and RANTES, activating cell surface ligands such as CD40L, N-acetylmuramine-L-alanyl- D-isoglutamine (MDP), and thymosin α1. The amount of adjuvant used will suitably depend on the severity of the symptoms that may develop as part of the immune response in humans or animals after administration of this type of vaccine, such as softening of the skin, pain, erythema, fever, headache, and muscle pain. can be selected.

In a further embodiment, the use of various other adjuvants, drugs or additives in conjunction with a vaccine of the invention as discussed above may enhance the therapeutic effect achieved by administration of the vaccine or pharmaceutical composition. Pharmaceutically acceptable carriers may contain minor amounts of additives, such as substances that enhance isotonicity and chemical stability. Such additives must be nontoxic to human or other mammalian subjects at the dosages and concentrations employed, examples of which include buffers such as phosphoric acid, citric acid, succinic acid, acetic acid, and other organic acids, and salts thereof; antioxidants such as ascorbic acid; low molecular weight (eg, less than about 10 residues) polypeptides (eg, polyarginine and tripeptides) proteins (eg, serum albumin, gelatin, and immunoglobulins); amino acids (eg, glycine, glutamic acid, aspartic acid, and arginine); monosaccharides, disaccharides, and other carbohydrates (eg, cellulose and its derivatives, glucose, mannose, and dextrins), chelating agents (eg, EDTA); sugar alcohols (eg, mannitol and sorbitol); counterions (eg, sodium); nonionic surfactants (eg, polysorbates and poloxamers); Antibiotic; and PEG.

Vaccines or pharmaceutical compositions containing sMVA described herein may be stored as aqueous solutions or lyophilized products in unit or multi-dose containers such as sealed ampoules or vials.

Prevention or treatment of viral infection or cancer

A poxvirus reconstituted from one or more naturally derived or chemically synthesized DNA fragment(s) with or without inserted antigen, subunits or fragments thereof, or other heterologous sequences, can prevent various viral infections or cancers or It can be used as a vaccine composition for treatment. One of ordinary skill in the art would know how to select a particular viral or cancer antigen for a condition or disease to be prevented or treated. This may include, but is not limited to, any infectious disease or cancer antigen capable of eliciting an immune response, such as a viral envelope glycoprotein or glycoprotein complex, an immunodominant T cell antigen, or a mutated cancer neoantigen. These antigenic sequences, or portions thereof, are derived from a virus such as CMV, EBV, KSHV, other herpesviruses, Zika virus, Lassa virus, HCV, HBV, coronavirus, influenza, or any other virus, bacteria, or other form of an infectious pathogen. or may be based on it.

The following examples are intended to illustrate various embodiments of the invention. Accordingly, the specific embodiments discussed should not be construed as limitations on the scope of the invention. It will be apparent to those skilled in the art that various equivalents, changes, and modifications can be made without departing from the scope of the invention, and it is understood that such equivalent embodiments should be embraced herein. Additionally, all references cited in this disclosure are hereby incorporated by reference in their entirety as if fully set forth herein.

Example

Example 1: Reconstitution of sMVA Using Synthetic MVA Fragment in Circular Form

As an initial test to validate the sMVA platform, the procedure as illustrated in Figure 2 was used to evaluate the reconstruction of sMVA from three sMVA fragments in a circular form. EPI300 or DH10B EPI300 or DH10B allowing stable propagation of the cloned large DNA fragment as ⁴¹ BAC by alkaline lysis of three sMVA fragments (F1 to F3). It was isolated from E. coli and co-transfected (˜1-2 μg/fragment) into monolayers of BHK cells (6-well plate format) by lipofection as a circular plasmid ( FIG. 5 ). At 4 h post infection (hpi), BHK cells were infected with helper FPV at a multiplicity of infection (MOI) of 0.1 to initiate MVA transcription and DNA replication. FPV-infected BHK cells transfected with only one or a combination of only two of the MVA fragments, mock-infected (uninfected) BHK cells transfected with all three MVA fragments, and mock-transfected BHK cells infected with FPV as controls was used as Transfected/infected BHK cells were grown under appropriate conditions and dispersed (passaged) in a ˜1:2 to 1:3 ratio into a larger tissue culture format using the procedure as illustrated in FIG. 5 every 2 days. FPV-infected BHK cells transfected with all three synthetic MVA fragments 3-6 days post-transfection/infection (dpt/i) with signs of viral plaque formation and progression and cytopathic effect (CPE) demonstrating reconstitution of sMVA was detected in the monolayer. At 7-8 dpt/i after dispersal of FPV-infected BHK cells transfected with all three MVA fragments, the derived BHK cell monolayer showed 90-100% infection. In contrast, no characteristic signs of MVA virus plaque formation or CPE were observed in any controls. MVA infection and spread at 16-72 hpi using sMVA prepared by conventional freeze/thaw methods from BHK cell monolayers with 100% CPE, titrated for BHK cells, and used to infect BHK cell monolayers at low MOI. was evaluated by immunostaining for the vaccinia virus glycoprotein B5R ^16,42 .

This analysis showed that reconstituted sMVA had a similar ability compared to MVA NIH clone 1 to form characteristic MVA virus foci and spread in BHK cell monolayers ( FIG. 6 ), indicating that sMVA from three sMVA fragments check the formation. Characteristic viral foci were detected in sMVA and MVA NIH-infected BHK cell monolayers 1 day post infection (dpi), but at 2 dpi MVA virus infection was visible in whole BHK cell monolayers infected with sMVA or MVA NIH, and at 3 dpi Most cells in BHK cell monolayers infected with sMVA or MVA NIH were isolated. In contrast, no characteristic MVA virus infection or CPE was detected in mock-infected controls. Other research groups have conclusively demonstrated that FPV used as a helper virus either does not give off genetic material or recombines with the MVA genome when introduced into transfection/infection incubation on BHK or CEF cells ^43,44 .

To characterize the genome of reconstituted sMVA, viral DNA prepared from sMVA-infected BHK cells was evaluated by PCR using primers specific for different genomic locations within three synthetic MVA fragments. DNA prepared from mock-infected (uninfected) BHK cells as well as BHK cells infected with NIH MVA clone 1 were used as controls. This PCR analysis revealed the presence of DNA derived from all three sMVA fragments within the genomic DNA of the reconstituted sMVA ( FIG. 7 ). All PCR products derived from sMVA-infected BHK cells were similar (in molecular weight) compared to those derived from MVA NIH-infected BHK cells. These include (1) PCR products derived from ITR sequences located within sMVA F1 and F3 ( FIG. 7A ); (2) PCR products corresponding to sMVA F1-derived DNA such as transfer of the left ITR to the left end of the internal UR ( FIG. 7B ), and the Del2 insertion site ( FIG. 7C ); (3) sMVA F2-derived DNA such as a PCR product corresponding to the G1L/I8R insertion site (IGR69/70) ( FIG. 7D ); and sMVA F3-derived DNA such as a Del3 insertion site ( FIG. 7E ), a PCR product corresponding to the transition of the right end of the inner UR to the right ITR ( FIG. 7F ). In addition, PCR analysis using primers with binding sites flanked by sMVA F1/F2 or sMVA F2/F3 overlapping homology sequences (Figure 1) showed similar product sizes for MVA and MVA NIH-infected BHK cells. ( FIGS. 7G-7H ), indicating successful recombination of the three sMVA fragments and removal of the vector sequence in sMVA.

Sanger sequencing analysis of all PCR products derived from sMVA-infected BHK cells revealed sequences at these genomic locations identical to published SEQ ID NOs: ²⁶ of MVA strain Antoine containing recombination sites of F1/F2 and F2/F3. . The only exception to this was a PCR product derived from the Del2 site of sMVA, which exhibits a single T to A nucleotide change located at the IGR 3 base pairs downstream of the open reading frame (ORF) 021L ²⁶ . BLAST analysis indicated that this sequence alteration in the sMVA DNA was not present in any published MVA or vaccinia virus genomic sequences. this. Sanger sequence analysis of sMVA F1 purified from E. coli showed that this specific nucleotide alteration at the Del2 site was already present prior to sMVA reconstitution in BHK cells, indicating that either it had its origin in the chemical synthesis of F1 or that it . It is suggested that this is the result of cloning or propagation of sMVA F1 in E. coli. Further sequencing analysis of PCR products derived from sMVA-infected BHK cells ( FIGS. 7I-7L ) showed that the sMVA genomic sequence contains all five Antoine-specific nucleotide polymorphisms of the internal UR that distinguish it from the genomic sequence of MVA NIH clone 1 showed that

The following DNA sequence is provided as the nucleotide sequence (5' to 3') of the sense strand of the DNA molecule. Sequence of sMVA fragment 1 (F1, 60021 bp in length) (SEQ ID NO: 11):

Any of the sequences of sMVA fragments F1, F2, and F3 may contain one or more alterations or mutations. For example, the sequence of sMVA fragment F1 (deposited to NCBI under accession number MW023923, www.ncbi.nlm.nih.gov/nuccore/MW023923.1/) is 1 downstream of the non-coding decision region of open reading frame 021. contains nucleotide alterations (SEQ ID NO: 12):

Sequence of sMVA fragment 2 (F2, 63035 bp in length) (deposited at NCBI under accession number MW023924, www.ncbi.nlm.nih.gov/nuccore/MW023924.1/) (SEQ ID NO: 13):

Sequence of sMVA fragment 3 (F3, 62068 bp in length) (SEQ ID NO: 14):

Alternatively, the sequence of sMVA F3 may contain one nucleotide alteration in the non-coding determining region at 88 bp proximal to the end of the ITR sequence (deposited to NCBI under accession number MW030459, www.ncbi.nlm. nih.gov/nuccore/MW030459.1/) (SEQ ID NO: 15):

Also disclosed are examples of synthetic vaccinia virus (sVAC) fragments for reconstructing the complete vaccinia virus genome. Exemplary sequence of sVAC fragment 1 (F1, 66679 bp in length) (SEQ ID NO: 16):

Example of sVAC fragment 2 (F2, 66679 bp long) (SEQ ID NO: 17):

Exemplary sequence of sVAC fragment 3 (F3, 66679 bp in length) (SEQ ID NO: 18):

To evaluate the removal of bacterial vector sequences after sMVA reconstitution, DNA from sMVA-infected BHK cells during serial viral passage of sMVA in BHK cells was subjected to PCR using primers specific for the sopA and cat chloramphenicol resistance genes of the bacterial vector. evaluated by This PCR analysis indicated that residual vector sequences could be detected in sMVA DNA at 7 or 8 dpt/i, although after two additional viral passages of sMVA were not detectable in sMVA DNA. Taken together, these results show that co-transfection of three synthetic MVA fragments as circular plasmid molecules into FPV-infected BHK cells appears to have a sequence composition similar to that of the published genome SEQ ID NO: ²⁶ of MVA strain Antoine, a full-length, vector-free genome. provides evidence that it causes the formation of sMVA with

Example 2: Generation of recombinant sMVA expressing a single heterologous gene sequence

To evaluate the use of three sMVA fragments to generate ^rsMVA , the three fragments were transformed into GS1783 e. transferred to E. coli cells ⁴⁰ . This highly efficient method allows the introduction of point mutations or large or small sequence insertions or deletions into BAC cloned DNA molecules by a two-step mutagenesis procedure based on red recombination that leaves no bacterial marker sequences ^39,40 . As an initial test of the sMVA platform to generate rsMVA expressing heterologous gene sequences, the generation of rsMVA expressing a single fluorescent marker was evaluated. 18,24 As previously described for insertion of the antigenic sequence into ^MVABAC -TK, umbilical mutagenesis was performed using an expression cassette consisting of a red fluorescent protein (RFP) marker with an upstream mH5 promoter and a downstream TTTTTAT vaccinia virus transcription termination signal. F2-RFP was generated using insertion into the IGR69/70 (also known as G1L/I8R) insertion site in sMVA fragment F2 ( FIG. 3 ). The sequence integrity of the engineered sMVA fragment was determined by restriction fragment length polymorphism (RFLP) analysis of the gene insertion site as well as PCR and Sanger sequencing analysis. The modified sMVA fragment F2 with the inserted RFP marker as well as the unmodified sMVA fragments F1 and F3 were transferred to E. Reconstitution of rsMVA in the presence of FPV as a helper virus was evaluated using a procedure as illustrated in FIG. 5 by isolation from E. coli and co-transfection into BHK cells. As shown in Figure 8, immunofluorescence imaging revealed the formation and progression of red fluorescent viral plaques in BHK cell monolayers transfected with the F1/F2-RFP/F3 plasmid combination at 3-6 dpt/i, but at 7 dpt/i. In i, RFP expression was visible in the whole BHK cell monolayer. In contrast, RFP expression was not visible in mock-transfected/infected BHK cell monolayers. Taken together, these results demonstrate that the sMVA platform can be used to rapidly generate rsMVA expressing a single heterologous gene sequence.

Example 3: Generation of recombinant sMVA expressing two heterologous gene sequences

To evaluate the sMVA platform for the generation of rsMVA with multiple heterologous gene sequences inserted into different genomic locations, the construction of rsMVA expressing two fluorescent markers was evaluated. Using umbilical mutagenesis of GS1783 cells, gene expression cassettes consisting of the P11 promoter, RFP marker or blue fluorescent protein (BFP) marker, and TTTTTAT transcription termination signal were individually transfected into the IGR69/70 of sMVA F2 and the Del3 sites of sMVA F3. inserted into The modified sMVA F2 (F2-RFP) with the inserted RFP marker and the modified sMVA F3 (F3-BFP) with the inserted BFP marker were combined with GS1783 E. Reconstitution of rsMVA with RFP and BFP markers in the presence of helper virus was assessed using the procedure presented in FIG. 5 by isolation from E. coli cells and co-transfection into BHK cells with unmodified sMVA F1. As shown in Figure 9, immunofluorescence imaging revealed the formation of double fluorescent (red and blue) viral plaques of BHK cell monolayers co-transfected with the F1/F2-RFP/F3-BFP plasmid combination at 3-6 dpt/i. , and at 7 dpt/i most or all of the BHK cells appeared to express RFP and BFP dual fluorescent protein expression. These results provide evidence that the sMVA platform can be used to rapidly generate rsMVA expressing two heterologous gene sequences inserted into different insertion sites.

Example 4: Generation of recombinant sMVA expressing three heterologous gene sequences

To further evaluate the sMVA platform for the generation of rsMVA with multiple inserted heterologous gene sequences, the generation of rsMVA expressing three fluorescent markers was investigated. this. Green fluorescent protein (GFP) markers were inserted into the IGR44/45 of MVA F1, along with the upstream P11 promoter and downstream transcription termination signal, using en wave mutagenesis in E. coli. The resulting modified sMVA fragment F1 (F1-GFP) with the GFP marker inserted was then transfected with fluorescently tagged forms of F2 and F3 (F2-RFP and F3-BFP) as well as unmodified F1, F2, and F3. Single, double, or triple fluorescent sMVA expression vectors were evaluated using the procedure shown in FIG. 5 by testing different combinations of sMVA fragments. The fragment combinations used for co-transfection were F1-GFP/F2-RFP/F3-BFP, F1-GFP/F2-RFP/F3, F1-GFP/F2/F3-BFP, F1/F2-RFP/F3- BFP, F1-GFP/F2/F3, F1/F2-RFP/F3, and F1/F2/F3-BFP. Co-transfection of three non-modified sMVA fragments (F1/F2/F3) into FPV-infected BHK cells was evaluated as a negative control. Except for the negative control, fluorescent gene expression was observed in BHK cell monolayers transfected with any of the different fragment combinations at 3-6 dpt/i by immunofluorescence imaging. At 7-8 dpt/i, fluorescent marker expression was observed in most cells of the BHK monolayer, indicating reconstitution of the fluorescent recombinant sMVA expression vector. Recombinant sMVA expression vectors were prepared by freeze/thaw technique, titrated to BHK cells, and used to infect BHK cell monolayers at low MOIs. At 16-24 hpi, infected BHK cell monolayers were evaluated by IF imaging to confirm the formation and reconstitution of sMVA expressing different fluorescent marker sequences. This assay analyzed triple fluorescence expression in BHK cell monolayers infected with F1-GFP/F2-RFP/F3-BFP-derived sMVA; double fluorescence expression in BHK cell monolayers infected with F1-GFP/F2-RFP/F3, F1-GFP/F2/F3-BFP, or F1/F2-RFP/F3-BFP-derived sMVA; and formation of viral foci that exhibited single fluorescence expression in BHK cell monolayers infected with F1-GFP/F2/F3, F1/F2-RFP/F3, or F1/F2/F3-BFP-derived sMVA. Taken together, these results show that the three sMVA fragments are E. It shows that it can be used as a circular DNA molecule to reconstruct single, double, or triple recombinant sMVA expression vectors engineered in E. coli, highlighting the potential of three sMVA fragments to generate recombinant vaccine vectors.

Example 5: Construction and evaluation of examples of infectious disease antigen-modified MVA

To demonstrate the utility of the sMVA platform for generating multi-antigen vaccine vectors against infectious diseases, rsMVA expressing five members of the HCMV envelope pentamer complex (PC) consisting of gH, gL, UL128, UL130, and UL131A evaluate the construction of Antigen expression cassettes composed of 2A-linked gH/gL and UL128/UL130/UL131A subunits were individually isolated from E. In E. coli, hem-wave mutagenesis was used to insert into the IGR69/70 located in sMVA F2 and the Del3 site located in sMVA F3. The modified sMVA fragments of F2 and F3 together with the unmodified sMVA fragments of F1 were transfected into FPV-infected BHK cells to reconstruct sMVA expressing all five PC subunits (rsMVA-PC). As a control, rsMVA expressing only gH/gL or UL128/130/131A subunits as well as sMVA without any inserted antigen sequence are generated. The expression of the antigen sequence was confirmed by Western blot, and the formation of a multi-protein complex by the PC subunit expressed from rsMVA-PC was a neutralizing antibody (NAb) targeting a structural epitope formed by two or more subunits of PC. Confirm by flow cytometry (FC) using To investigate the immunogenicity of rsMVA-PC vectors stimulating NAb, Balb/c mice are immunized three times with rsMVA-PC or control vectors at 4-week intervals by the intraperitoneal route. At various time points after immunization, HCMV-specific NAb responses are measured for MRC-5 fibroblasts (FB) and ARPE-19 epithelial cells (EC). This assay can reveal potent stimulation of FB and EC-specific NAb responses in mice immunized with rsMVA-PC, whereas no or only minimal responses are measured in mice immunized with control vectors. . These results can demonstrate that the sMVA vaccine platform can be used to generate multi-antigen MVA vaccine vectors that assemble together to form NAb epitopes and express all five PC subunits that stimulate robust NAb responses in mice. .

Example 6: Construction and evaluation of 2019-nCoV expressed from sMVA

Examples of the utility of the sMVA platform for generating vaccines against the recently emerged coronavirus strain 2019-nCoV (Wuhan) as a novel, highly contagious and pathogenic coronavirus are illustrated. As the S (spike) protein of coronavirus is involved in receptor recognition, as well as virus attachment and entry, and is the predominant target for protecting humoral and cellular immunity, it has potential for the development of coronavirus (CoV) vaccines and therapeutics. indicates a target. cDNAs encoding the full-length S protein (~1273 amino acids), the immunogenic S1 domain of the S protein, or the receptor binding domain (RBD) of the S1 domain of the 2019-nCoV strain are individually inserted into the MVA Del3 site of the sMVA fragment F3 . The resulting modified fragment of sMVA F3 was then co-transfected with unmodified versions of sMVA fragments F1 and F2 into BHK cells using the procedure as exemplified in FIG. 5 for novel coronavirus S protein (sMVA- Reconstitution of sMVA expressing 2019-nCoV-S), S1 domain (sMVA-2019-nCoV-S1), or RBD domain (sMVA-2019-nCoV-RBD) is disclosed. Expression of the S protein, S1 domain, or RBD domain from the sMVA recombinant is confirmed by immunoblot and flow cytometry analysis. Convalescent sera from infected humans, mice or rabbits are used as detection reagents for immunoblots. In some cases, tags such as HA are covalently attached to the carboxyl terminus, and antibodies to them are used as detection reagents for immunoblot or flow cytometry. Similarly, multi-antigen vaccines are developed by inserting additional immunogenic proteins, such as N or M antigens from 2019-nCoV, into the native gene insertion region of sMVA. For example, one or more of these 2019-nCoV antigens are inserted into one or more insertion sites such as the Del3 site of sMVA fragment F3 and IGR69/70 of sMVA fragment F2.

To test the immunogenicity and protective efficacy of sMVA constructs, two animal models can be used: (1) given the more severe symptoms observed in elderly individuals, 12-month-old Balb/c mice were treated by subcutaneous and intramuscular routes. immunized twice with 1x10 ⁷ -1x10 ⁸ sMVA plaque forming units (Pfu) at 4 week intervals by (2) Considering the potential involvement of human angiotensin-converting enzyme-2 (hACE-2) in nCoV entry into lung cells, transgenic mice expressing the human hACE2 receptor are used to test vaccine efficacy.

To test the immunogenicity and protective efficacy of sMVA constructs, Balb/c mice transgenic for angiotensin converting enzyme 2 (ACE2) were treated with 1x10 ⁷ -1x10 ⁸ sMVA plaque forming units at 4-week intervals by subcutaneous and intramuscular routes. (Pfu) for two immunizations. Neutralizing antibody responses and T cell responses specific for 2019-nCoV-S proteins and derivatives are measured as previously described one week after each immunization. At 45 days post booster immunization, mice were infected with 7 x 10 ⁴ 50% tissue culture infectious dose (TICD50) of 2019-nCoV homologous to the vaccine antigen, and heterologous strains (SARS-CoV and MERS-CoV) and post-challenge. On day 4, animals are sacrificed and their lungs are harvested for measurement of viral load and histopathological analysis. On average, large viral loads of >11,000 to >20,000 2019-nCoV genome equivalents/ng of total RNA are found in both mock-immunized and non-recombinant MVA-immunized control groups and animals challenged with the heterologous CoV strain . In sharp contrast, the lung tissue of the protein (sMVA-nCoV-S) or S1 domain (sMVA-nCoV-S1) subjects contained significantly lower levels of 2019-nCoV RNA (viral load), which was vaccine-derived. Shows efficient inhibition of 2019-nCoV replication by immune response. All placebo control animals (MVA-GFP) succumbed 4-8 days post infection, but MVA-S, MVA-N and MVA-N/S showed minimal signs of disease, including minimal weight loss, or does not indicate this MVA-N/S immunized mice are fully protected.

Histopathology focuses on substantially reduced lung injury in 2019-nCoV subunit antigen immunized animals. The potential for antibody-enhancing the disease is also assessed and found absent in these subunit vaccine models. NAb responses to S protein antigens and their S1 and RBD derivatives are evaluated using a pseudotyping strategy for nCoV that is robust for recognition by antigen-specific NAbs, but the use of pathogenic strains of CoV is avoided. Sera from animals immunized with the S protein and derivatives elicit high titers and neutralizing antibodies against the homologous 2019-nCoV strain, but not the pathogens against heterologous CoV strains such as MERS and SARS. IC90 neutralizing titers are calculated for each mouse serum sample. Building on the success of vaccine studies in the transgenic ACE2 Balb/c mouse strain, continue to larger animal species, namely rabbits, ferrets, and rabbits, ferrets, and known to respond to MVA-based vaccines with sensitivity to the 2019-nCoV challenge. Examine the rhesus macaque.

Example 7: Construction and evaluation of examples of cancer antigen-modified sMVA

This example demonstrates the insertion of the mouse p53 gene, previously used in studies, into the MVA backbone obtained from ATCC or NIAID ⁴⁶ . Mouse p53 cDNA is inserted into the deletion (DEL3) locus using an umbilical cord so that no additional nucleotide additions or removals are made at the correct insertion site of the locus. Insertion is confirmed by sequencing to ensure that the insertion is correct and all relevant regions are intact and 100% sequence identifiable. Following modification of plasmid F3, all three plasmids were combined in a single aliquot using the same method as described in Example 2, to generate a modified version of sMVA, and transfection/infection of live virus with FPV 2 obtained after one day. Live virus was concentrated and expanded on BHK cells, stock prepared, and sequenced using Sanger method to establish that the virus had the correct sequence of the p53 gene insertion at the DEL3 locus. Moreover, virus stocks are prepared, frozen and stored for long periods of time, while working stocks are prepared using published methods to expand the modified sMVA stock to titers of ≧1× ^{10 9} pfu/mL. Identification of the expanded stock is performed using a combination of qPCR, Sanger sequencing, infectivity titer, and Western blot analysis. All four of these procedures were performed and appropriate results were obtained to confirm that the nucleotide sequence had an appropriate size, and the infectivity titer was in the range of ≥1x10 ⁹ pfu/mL, and Western blot analysis identified a protein band at approximately 53 Kd. do. A person skilled in the art can apply this approach as a vaccine to protect humans from cancer progression using a human version of the p53 gene.

Murine (mu) p53-sMVA

Female 6-8-week-old BALB/C mice are obtained from Jackson Laboratory (Bar Harbor, MA) and maintained in a specific pathogen-free environment. All studies are approved by the Research Animal Care Committee of the City of Hope National Medical Center and are conducted under American Association for the Accreditation of Laboratory Animal Care guidelines. Meth A sarcoma cells (Meth A) are donated by Dr. LJ Old, Memorial Sloan-Kettering Cancer Center (New York, NY). Meth A is passaged as an ascites tumor. Anti-CTLA-4 (9H10) was donated by Dr. James Allison, MD Anderson Cancer Center (Houston, Texas). Antibodies are produced using a CELLine device (BD Biosciences, Mountain View, CA). IgG antibodies are purified by uptake over protein G-Sepharose (Amersham Biosciences, Uppsala, Sweden) followed by elution with 0.1 M glycine-HCL, pH 2.7. The product is dialyzed against phosphate-buffered saline and concentrated using a Sentry Plus centrifugal filter apparatus (Millipore, Bedford, MA). Control Syrian hamster IgG is obtained from Jackson ImmunoResearch (West Grove, PA). rsMVA titers are determined by immunostaining infected cultures using the VECTASTAIN Elite ABC kit (Vector Laboratories, Burlingame, CA). Antigen-specific detection of mouse p53 protein expressed from sMVA uses an anti-p53 antibody, pab122, followed by incubation with a peroxidase-labeled goat anti-mouse secondary antibody provided in the kit. Control sMVA expressing CMV-pp65 was also constructed using the same technique as used for construction of murine sMVAp53.

In vivo tumor challenge experiments

6-week-old female BALB/C mice are injected with 5×10 ⁵ METH A cells in the left flank by subcutaneous route. On day 3, mice are treated with 5x10 ⁷ pfu of sMVAp53 by intraperitoneal injection. Negative control mice are injected with 5x10 ⁷ pfu of sMVApp65 or phosphate buffered saline. An additional positive control uses the same murine MVAp53 described in the original report. Subcutaneous tumors are evaluated weekly by the IVIS imaging method using luciferase technology or by calipers if the luciferase gene has not been inserted into METH A sarcoma cells. An additional approach is to inject 1X10 ⁶ METH A cells into the left flank into BALB/C mice of the same age as the sMVA infection. This tumor appears to produce rapidly lethal tumors in many mice despite CTLA-4 (9H10) antibody treatment. Seven days after tumor inoculation, mice are intraperitoneally injected with 5x10 ⁷ pfu of sMVAp53. Controls are the same as described above. Anti-CTLA-4 (9H10) antibody or control hamster antibody is injected intraperitoneally at doses of 100, 50, and 50 micrograms, respectively, on days 6, 9, and 12 after tumor injection.

Example 8: Construction and characterization of sMVA in vitro and in vivo

The three sMVA fragments designed as shown in Figure 1, when co-transfected into helper virus infected cells as circular DNA plasmids, can degrade into linear minichromosomes and recombine with each other via shared homologous sequences, and ultimately packaged as a full-length MVA genome. All three sMVA fragments were identified as bacterial artificial chromosome (BAC) clones in E. It was cloned into E. coli.

^16,24,25 , using the procedure previously used to obtain MVA from BAC, upon co-transfection of the three DNA plasmids into BHK cells that are non-permissive to fowlpox (FPV) with sMVA virus (Figure 2). Reconstituted using FPV as helper virus. Two different FPV strains (HP1.441 and TROVAC) were used to facilitate sMVA virus reconstitution ( FIG. 12A ). Ultra-purified sMVA virus was produced after viral propagation in CEF, which is commonly used for MVA vaccine production. The viral titers achieved with the reconstituted sMVA virus were similar to those achieved with wild-type MVA (wtMVA) (Table 1 below).

To characterize the viral DNA of sMVA, DNA extracts from sMVA and wtMVA-infected CEFs were compared for several MVA genomic locations by PCR. Similar PCR results were obtained for all evaluated genomic positions containing F1/F2 and F2/F3 recombination sites with sMVA and wtMVA ( FIG. 11A ), indicating efficient recombination of the three sMVA fragments. Additional PCR analysis revealed the absence of any BAC vector sequences in the sMVA virus DNA ( FIG. 11A ), suggesting a spontaneous and efficient removal of bacterial vector elements upon sMVA virus reconstitution. Comparison of viral DNA from ultra-purified sMVA and wtMVA viruses by restriction enzyme digestion revealed similar genomic patterns between sMVA and wtMVA ( FIG. 11B ). Sequencing analysis of sMVA viral DNA confirmed the MVA genomic sequence at several locations, including F1/F2 and F2/F3 recombination sites. Moreover, whole genome sequencing of one of the sMVA virus isolates reconstituted with FPV TROVAC confirmed the assembly of the reference MVA genomic sequence and the absence of vector-specific sequences in the viral DNA, including from the reconstituted sMVA virus.

To characterize the replication properties of sMVA, the growth rates of sMVA and wtMVA were compared on BHK and CEF cells, two cell types known to support productive MVA replication ⁴ . This analysis revealed similar growth rates of sMVA and wtMVA in both BHK and CEF cells (Fig. 12B). In addition, similar areas of viral foci were determined in BHK and CEF cell monolayers infected with sMVA or wtMVA (Fig. 12C), suggesting a similar ability of sMVA and wtMVA to spread in MVA-permissive cells. Compared to the productive replication of sMVA and wtMVA in BHK and CEF cells ⁴ , only limited viral production was observed after infection of various human cell lines with sMVA or wtMVA ( FIG. 12D ). These results are consistent with the severely limited replication properties of MVA and indicate that the sMVA virus can efficiently proliferate in BHK and CEF cells, but not in human cells.

To characterize sMVA in vivo, the immunogenicity of sMVA and wtMVA was compared after two immunizations at high or low doses in C57BL/6 mice. MVA-specific binding antibodies stimulated by sMVA and wtMVA after the first and second immunizations were comparable ( FIGS. 13A, 14A ). Antibody levels in the high dose vaccine group exceeded those of the low dose vaccine group after the first immunization, but similar antibody levels in the high and low dose vaccine groups were observed after the second immunization. In addition, no significant difference was detected in the level of MVA-specific NAb responses induced by sMVA and wtMVA after the second immunization ( FIGS. 13B, 14B ). MVA-specific T cell responses determined by ex vivo antigen stimulation with immunodominant peptides after booster immunization revealed similar MVA-specific T cell levels in mice receiving either ⁴⁷ sMVA or wtMVA ( FIGS. 13C-13D and 14C- 14D). These results indicate that the sMVA virus has a similar ability to wtMVA in the induction of MVA-specific humoral and cellular immunity in mice.

references

The references listed below, patents and published patent applications, and all references cited in the above specification are hereby incorporated by reference in their entirety as if fully set forth herein.

SEQUENCE LISTING <110> CITY OF HOPE <120> POXVIRUS-BASED VECTORS PRODUCED BY NATURAL OR SYNTHETIC DNA AND USES THEREOF <130> 054435-8200.WO00 <150> US 62/969,628 <151> 2020-02-03 <150> US 63/113,803 <151> 2020-11-13 <160> 18 <170> PatentIn version 3.5 <210> 1 <211> 215 <212> DNA <213> Artificial Sequence <220> <223> terminal CR-HL-CR <220> <221> misc_feature <222> (1)..(20) <223> poxvirus concatemeric resolution <220> <221> misc_feature <222> (26)..(190) <223> MVA terminal hairpin loop <220> <221> misc_feature <222> (196)..(215) <223> poxvirus concatemeric resolution <400> 1 tttttttcta gacactaaat aaatagtaag attaaattaa ttataaaatt atgtatataa 60 tattaattat aaaattatgt atatgattta ctaactttag ttagataaat taataataca 120 taaattttag tatattaata ttataaatta ataatacata aattttagta tattaatatt 180 atattttaaa tattttatta gtgtctagaa aaaaa 215 <210> 2 <211> 215 <212> DNA <213> Artificial Sequence <220> <223> terminal CR-HL-CR <220> <221> misc_feature <222> (1)..(25) <223> poxvirus concatemeric resolution <220> <221> misc_feature <222> (26)..(190) <223> MVA terminal hairpin loop <220> <221> misc_feature <222> (191)..(215) <223> poxvirus concatemeric resolution <400> 2 tttttttcta gacactaaat aaatatttaa aatataatat taatatacta aaatttatgt 60 attattaatt tataatatta atatactaaa atttatgtat tattaattta tctaactaaa 120 gttagtaaat catatacata attttataat taatattata tacataattt tataattaat 180 ttaatcttac tatttattta gtgtctagaa aaaaa 215 <210> 3 <211> 165 <212> DNA <213> Artificial Sequence <220> <223> MVA terminal hairpin loop <400> 3 gtaagattaa attaattata aaattatgta tataatatta attataaaat tatgtatatg 60 atttactaac tttagttaga taaattaata atacataaat tttagtatat taatattata 120 aattaataat acataaattt tagtatatta atattatatt ttaaa 165 <210> 4 <211> 165 <212> DNA <213> Artificial Sequence <220> <223> MVA terminal hairpin loop <400> 4 tttaaaatat aatattaata tactaaaatt tatgtattat taatttataa tattaatata 60 ctaaaattta tgtattatta atttatctaa ctaaagttag taaatcatat acataatttt 120 ataattaata ttatatacat aattttataa ttaatttaat cttac 165 <210> 5 <211> 154 <212> DNA <213> Artificial Sequence <220> <223> terminal CR-HL-CR <220> <221> misc_feature <222> (1)..(25) <223> poxvirus concatemeric resolution <220> <221> misc_feature <222> (26)..(129) <223> Vaccinia terminal hairpin loop <220> <221> misc_feature <222> (130)..(154) <223> poxvirus concatemeric resolution <400> 5 tttttttcta gacactaaat aaaatattta aaatataata ttaatgtact aaaacttata 60 tattattaat ttatctaact aaagttagta aattatatat ataattttat aattaattta 120 attttactaa ttttatttag tgtctagaaa aaaa 154 <210> 6 <211> 154 <212> DNA <213> Artificial Sequence <220> <223> terminal CR-HL-CR <220> <221> misc_feature <222> (1)..(25) <223> poxvirus concatemeric resolution <220> <221> misc_feature <222> (26)..(129) <223> Vaccinia terminal hairpin loop <220> <221> misc_feature <222> (130)..(154) <223> poxvirus concatemeric resolution <400> 6 tttttttcta gacactaaat aaaattagta aaattaaatt aattataaaa ttatatatat 60 aatttactaa ctttagttag ataaattaat aatatataag ttttagtaca ttaatattat 120 attttaaata ttttatttag tgtctagaaa aaaa 154 <210> 7 <211> 104 <212> DNA <213> Artificial Sequence <220> <223> Vaccinia virus terminal hairpin loop <400> 7 tagtaaaatt aaattaatta taaaattata tatataattt actaacttta gttagataaa 60 ttaataatat ataagtttta gtacattaat attatatttt aaat 104 <210> 8 <211> 104 <212> DNA <213> Artificial Sequence <220> <223> Vaccinia virus terminal hairpin loop <400> 8 atttaaaata taatattaat gtactaaaac ttatatatta ttaatttatc taactaaagt 60 tagtaaatta tatatataat tttataatta atttaatttt acta 104 <210> 9 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> MVA concatemer resolution <400> 9 tttttttcta gacactaaat 20 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> MVA concatemer resolution <400> 10 atttagtgtc tagaaaaaaa 20 <210> 11 <211> 60021 <212> DNA <213> Artificial Sequence <220> <223> sMVA fragment 1 <400> 11 ggcctagcag gccggccttt ttttctagac actaaataaa tagtaagatt aaattaatta 60 taaaattatg tatataatat taattataaa attatgtata tgatttacta actttagtta 120 gataaattaa taatacataa attttagtat attaatatta taaattaata atacataaat 180 tttagtatat taatattata ttttaaatat ttatttagtg tctagaaaaa aatgtgtgac 240 caacgaccgt aggaaactct agagggtaag aaaaatcaat cgctttatag agaccatcag 300 aaagaggttt aatatttttg tgagaccatc gaaggagaaa gagataaaac ttttttacga 360 ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac 420 ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa 480 gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg 540 aaggagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 600 agaccatcga aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat 660 atttttgtga gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag 720 aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 780 catcagaaag aggtttaata tttttgtgag accatcgaag gagaaagaga taaaactttt 840 ttacgactcc a tcagaaaga ggtttaatat ttttgtgaga ccatcgaaga gagaaagaga 900 ataaaaatat tttagtgaca ccatcagaaa gaggtttaat atttttgtga gaccatcgaa 960 gagagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 1020 gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag aggtttaata 1080 tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc catcagaaag 1140 aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 1200 catcagaaag accatcgaag agagaaagag aaagagatag ttagtctaga tatttttctt 1260 agtacaaaag tcaatgtttt aaaatatatg gacaagaatt tgtctgtata aaaacttgtg 1320 tgaaattttg taccaaagaa aaaatgtgag cagtatcccc tacatggatt ttactagatc 1380 atttatatac caaaaaatat tatacgatct acgttttatt atatgatttt aacgtgtaaa 1440 ttataaacat tattttatga tatacaattg tctggtaacc tagatgggca taggggatga 1500 gtatatgttg ttggacgtta ttgtttaaga aatagttgat gcatcagaaa gaggtttaat 1560 atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttacgact ccatcagaaa 1620 gaggtttaat atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttatgact 1680 ccattgaaga gagaatgag a ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1740 attttttatg agaccatcaa agagagaaag agaataaaaa tattttatga ctccattgaa 1800 gagagaaaga gaaaatgaga ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1860 attttttatg agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt 1920 tatgagacca tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag 1980 accatcaaag agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc 2040 aaagagagaa agagaataaa aatatttttg taaaactttt tttatgagac catcaaagag 2100 agaaagagaa taaaaatatt tttgtaaaac tttttttatg agaccatcaa agagagaaag 2160 agaataaaaa tatttttgta aaactttttt tatgagacca tcaaagagag aaagagaata 2220 aaaatatttt tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata 2280 ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca ccatcagaaa 2340 gaggtttaat atttttgtga gaccatcgaa gagagaaaga gaataaaaat attttatgac 2400 tccattgaag agagaaagag aataaaaata ttttagtgac accatcagaa agaggtttaa 2460 tattttttat gagaccatca aagagagaaa gagaataaaa atatttttgt aaaacttttt 2520 ttatgagacc atcaaagaga gaaa gagaat aaaaatattt ttgtaaaact ttttttatga 2580 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 2640 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 2700 gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 2760 gagaataaaa atattttatg actccattga agagagaatg agaataaaaa tattttagtg 2820 acaccatcag aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa 2880 aatattttat gactccattg aagagagaaa gagaataaaa atattttagt gacaccatca 2940 gaaagaggtt taatattttt tatgagacca tcaaagagag aaagagaata aaaatatttt 3000 tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 3060 acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 3120 tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 3180 agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 3240 tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag accatcaaag 3300 agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc aaagagagaa 3360 agagaataaa aatattttat gactccattg aagagagaat gagaataaaa atattttagt 3420 gacaccatca gaaagaggtt taatattttt gtgagaccat cgaagagaga aagagaataa 3480 aaatatttta tgactccatt gaagagagaa tgagaataaa aatattttag tgacaccatc 3540 agaaagaggt ttaatatttt ttatgagacc atcaaagaga gaaagagaat aaaaatattt 3600 ttgtaaaact ttttttatga gaccatcaaa gagagaaaga gaataaaaat atttttgtaa 3660 aaattataaa cattatttta tgatatacaa ttgtctggta acctagatgg gcatagggga 3720 tgttgataag ctcgacgagt atatgttgtt ggacgttatt gtttaagaaa tagttgatgc 3780 atcagaaaga gaataaaaaa tattttagtg agaccatcga agagagaaag agataaaact 3840 tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 3900 agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 3960 aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 4020 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 4080 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 4140 gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 4200 gagaataaaa atatttttgt aaaacttttt ttatg agacc atcaaagaga gaaagagaat 4260 aaaaatattt tatgactcca ttgaagagag aatgagaata aaaatatttt agtgacacca 4320 tcagaaagag gtttaatatt tttgtgagac catcgaagag agaaagagaa taaaaatatt 4380 ttatgactcc attgaagaga gaatgagaat aaaaatattt tagtgacacc atcagaaaga 4440 ggtttaatat tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 4500 acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 4560 tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 4620 agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 4680 tcaaagagag aaagagaata aaaatatttt atgactccat tgaagagaga atgagaataa 4740 aaatatttta gtgacaccat cagaaagagg tttaatattt ttgtgagacc atcgaagaga 4800 gaaagagaat aaaaatattt tatgactcca ttgaagagag aaagagaata aaaatatttt 4860 agtgacacca tcagaaagag gtttaatatt ttttatgaga ccatcaaaga gagaaagaga 4920 ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa gagaataaaa 4980 atattttatg actccattga agagagaatg agaataaaaa tattttagtg acaccatcag 5040 aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa aatattttat 5100 gactccattg aagagagaat gagaataaaa atattttagt gacaccatca gaaagaggtt 5160 taatattttt gtgagaccat cgaagagaga aagagaataa aaatatttta tgactccatt 5220 gaagagagaa tgagaataaa aatattttag tgacaccatc agaaagaggt ttaatatttt 5280 ttatgagacc atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga 5340 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 5400 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 5460 gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat 5520 ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga 5580 gagaaagaga ataaaaatat tttatgactc cattgaagag agaaagagaa taaaaatatt 5640 ttagtgacac catcagaaag aggtttaata tttttgtgag accatcgaag agagaaagag 5700 aataaaaata ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca 5760 ccatcagaaa gaggtttaat attttttatg agaccatcaa agagagaaag agaataaaaa 5820 tattttttat gagaccatca aagagagaaa gagaataaaa atattttatg agaccatcaa 5880 agagagaaag agaataaaaa tattttttat gagaccatca aagaga gaaa gagaataaaa 5940 atattttatg agaccatcaa agagagaaag agaataaaaa tattttttat gagaccatca 6000 aagagagaaa gagaataaaa atatttttgt atgagaccat cagaaagagg tttaatattt 6060 ttgtgatacc ctgaaaggaa ataggaatag tgtcataatc gtatcacact attgagacag 6120 aaaaagaaga agtcgcgaga ggtaactttt tgttttgcaa accggaatat agtgtccggt 6180 acactttttt aattcgtggt gtgcctgaat cgttcgatta accctactca tccaatttca 6240 gatgaataga gttatcgatt cagacacacg ctttgagttt tgttgaatcg atgagtgaag 6300 tatcatcggt tgcaccttca gatgccgatc cgtcgacata cttgacctca agttcagatg 6360 attccttgca catgtctccg atacgaacgc taaactctag attcttgaca cattttgtat 6420 cgacgatcgt tgaaccgatg atatcttcgt aactcacttt cttatgagag atgttagacc 6480 cgagtactgg atgggtcttg atgtcgctgt ctttctcttc ttcgctacat ctgatgtcga 6540 tagacacctc acagtctttc catcagcgga ttctgagatg gatttaatct gaggacattt 6600 ggtgaatcca aagttcattc tcagacctcc accgatgatg gagtaataag tggtaggagg 6660 atctacatcc tcgactgatt ccacctcggg atctggatct gactcggact ctgtaatttc 6720 cgttacggat tggcaaatct tatcatcggt cggtgtttgg tcttgctttg t gactttgat 6780 aataacatcg attcccatat gatgtttgtt ttcttcttcc gtacacgatg aggatgattg 6840 ctgaagactg gcaggcacat gcatgccagt acgatatatt gtttcatgat tgctattgat 6900 tgagtactgt tctttatgat tctacttcct taccgtgcaa taaattagaa tatattttct 6960 acttttacga gaaattaatt attgtattta tgggtgaaaa acttactata aaaagcgggt 7020 gggtttggaa ttagtgatca gtttatgtat atcgcaacta ccgggcatat ggctacatta 7080 cccacatgat aagagattgt atcagtttcg tagtcttgag tattggtatt actatatagt 7140 atatagatgt cgacgctaga gttactgtct ccgaatgcgg catgatagta tcattctttg 7200 ctttcgttaa ctgtttggag gaagaatctt tgttattgca tttaatctcg aaattcagag 7260 tgcacacctt tctcctgtaa agaaacctga agtcgctacc ttattaagaa gacgggatcg 7320 cagtctttat gattcatagt aatagttagt tccgacgttg agatggattc gctgagaccg 7380 gtagtggtcg tccgagtaca cgatgtgtcg ttaactggat acaggttaat ttccacatcg 7440 atatagttaa aggtatttct gggtacgggt tcgcatttat ctgcggaaga gacggtgtga 7500 gaatatgttc cgagaccaca cggagaacag atgacgtctc cggatactcc gtatcctatt 7560 ccacattttg tttgggaaac acatgccttg catccatgat cgggagagca ttcacag att 7620 ctattgtgag tcgtgttaca cgatcgcgtc gacattgttg acagaaacgt gaccttcatt 7680 cttaccgtcg tccataaata cgttaggtat gtaccacata ctgtcgcgaa cgatgcgtcc 7740 atctcataat gatttacttt ttcataatta aagatgtgaa agaaaaccga acaatatatt 7800 tttttagtaa tgtttatgcg agacatataa aataaactcc gtgtttatga tgccggtaaa 7860 tgtttttatc atcttggacg gaatcgattt tgtaatatgc catggaaaca ggacattatc 7920 actccatgat aaattattta atggagtcga tcctctcatt gttctttgcg tatctcaatc 7980 tgtggcgttt gcttcgttta aataatatat caaacatgga gacgcctgat atgtaggcat 8040 tcttcattct attaatgtct gctctatagc gctttagttc cttatgacga ccggcgatat 8100 catacttact ttagaaggaa aatcatcatc taggattaag gcgtatctga tacaggcgaa 8160 taatggttca ggatatagat agcgtatatc tctattaaat gcgtcaatca tagtctctag 8220 agtgggatgg taactcagta ataaatcaac tagcttctct ttggtaactg cttttctgga 8280 tggccgtatt gattatcgag cgtgacactc gctccatatt ccaataaccg ctttgcaaat 8340 tgtatattat tgacatcgac cgcgtaatat agtagagtta tcgatcatat ctatatcatc 8400 catgtacttg cttagtatat caaatacatc ttcataacag tgatacccgc aattattaaa 84 60 tctcgataat atcagaccgt acatacatag acggccattg ttagatatgt gatttacagc 8520 cgcgtgtcca tattttccac gataaacctt acgacgttta catcgacgag attattatta 8580 acaaagttgt tgtccgtcgt cttatccaac atgcattgaa tgataggtat acttaccata 8640 tcgccgtaat gtaagtagtt tatcagtatg gcttgtacga tggattcatc ctgttgtcta 8700 aatctcttta gaatgttatc gatgatgtag tggttatatt ctctggaatc gtacgaagta 8760 atactacgca ttacgtcgac aagagtatga cgtctctcaa taagaagatt aacgatttcc 8820 atgtctacat tatatggggt tactctaaat cgcttgttta gataatacgc ctctaatata 8880 gggctgacgt cgtatactct acacgtgtcc acatccttta ttaataatct ctatatctat 8940 ggttgagcaa gaccagtagt attggatgga aacattgtta tcgatcaaac atttaattac 9000 atccttggat agagattctc tatgagacga tatatagtaa tgaagagagt tcttacacat 9060 atcactgttg tacatacagg tacgaaatac gtaaccggtg ctgtaacatt ctgatttaag 9120 aagccatagc aatacttctg gtctcggatt aggcgtcgtt acgtatatat ccaccaatcc 9180 gagaccattg attgcataat tcgtattctt ggacggacgt atccgtttat ccacaattag 9240 gtattttagc agacgtaagt cgaaatcatt tatattcgac ttgagttcgt tagaggaatt 9300 cga atagctg gatatcagta gatgcacaat ctgagatttt acgtatctat gcttactgta 9360 tgctcctagc ggagttaatc cttcgttgtt tctacaaagt ctctcgactc cgcgagagag 9420 taacagtcga acaatcttaa tgtctgtatc gcatttattg gagacgtaac aatgtagcgc 9480 attgtttcct cgtctatcta tatgttttga taagttgtga cacgtttcaa tttctagttt 9540 tatttttttg tacgtcacat cttcatccag tagacgacat agaatacatg tgcaatccat 9600 agctattctg gtgctaatta ttcctcataa gatgataaaa agtgtagtga gagagcatga 9660 aggagattta gtatttagca gtgcggatat gatccaagag ggtgagatag tcgttctcgt 9720 tcagaatctt tcgcagcata agtagtatgt cgatatactt atcgttgaag actcttccag 9780 agacgatagc tgattgagta caaagtccaa tgattgcacg aagttcttcg gcggttttca 9840 tggagtcatt tctgatgaaa catttaatga tctaaatttc agtttatgtt tgtaccccgt 9900 attcatactt aacaaattgg tattacatac cattaataat gcaagcataa aaaatcgtta 9960 gtagatgttt ctaaatatag gttccgtaag caaagaatat aagaatgaag cggtaatgat 10020 aaaatcaatc gttatctaaa atgatcatac tcatttattt tattctatta tattaacaca 10080 tacattttta acagcaacac attcaatatt gtattgttat ttttatatta tttacacaat 10140 taacaa tata ttattagttt atattactga attaataata taaaattccc aatcttgtca 10200 taaacacaca ctgagaaaca gcataaacac aaaatccatc aaaaatgttg ataaattatc 10260 tgatgttgtt gttcgctgct atgataatca gatcattcgc cgatagtggt aacgctatcg 10320 aaacgacatc gccagaaatt acaaacgcta caacagatat tccagctatc agattatgcg 10380 gtccagaggg agatggatat tgtttacacg gtgactgtat ccacgctaga gatatcgacg 10440 gtatgtattg tagatgctct catggttata caggcattag atgtcagcat gtagtattag 10500 tagactatca acgttcagaa aaaccaaaca ctacaacgtc atatatccca tctcccggta 10560 ttatgcttgt attagtaggc attattatta ttacgtgttg tctattatct gtttataggt 10620 tcactcgacg aactaaacta cctatacaag atatggttgt gccataattt ttataaattt 10680 tttttatgag tatttttaca aaaatgtata aagtgtatgt cttatgtata tttataaaaa 10740 tgctaaatat gcgatgtatc tatgttattt gtatttatct aaacaatacc tctacctcta 10800 gatattatac aaaaattttt tatttcggca tattaaagta aaatctagtt accttgaaaa 10860 tgaatacagt gggtggttcc gtatcaccag taagaacata atagtcgaat acagtatccg 10920 attgagattt tgcatacaat actagtctag aaagaaattt gtaatcatct tctgtgacgg 1098 0 gagtccatat atctgtatca tcgtcccatg ctatattcct gttatcatca ttagttaatg 11040 aaaataactc tcgtgcttca gaaaagtcaa atattgtatc catacataca tctccaaaac 11100 tatcgcttat acgtttatct ttaacgatac ctatacctag atggttattt actaacagac 11160 attttccaga tctattgact ataactccta tagtttccac atcaaccaag taatgatcat 11220 ctattgttat ataacaataa cataactctt ttccgttttt atcagtatgt atatctatat 11280 caacgtcgtc gttgtagtga atagtagtca ttgatctatt atatgaaacg gatatgtcta 11340 gaacggcaat tgttttacgt ccagttaaca ctttcgttga tttaaagtct agagtctttg 11400 caaacataat atccttatcc gactttatat ttcctgtagg gtggtataat tttattttgc 11460 ctccacatat cggtgtttcc aaatatatta ctagacaata ttccatatag ttattagtta 11520 agggtaccca attagaacac gtacgcttat tatcatcatt tggatcgtat ttcataaaag 11580 ttattgtact atcgatgtca acacattcta cattttttaa tcgtctatat agtatttttc 11640 tgatattttc tataatatca gaattgtctt ccatcggaag ttgtatacta tcggaatcag 11700 ttacatgttt aaataattct ctgatgtcat tccttataca atcaaattca ttattaaaca 11760 gtttaatagt ctgtagacct ttatcgtcgt aaatatccat tgtcttatta gttacgc tta 11820 tttttatgtg tttttacgtt gctttattat attttataag aatgattgtt tgacgaatca 11880 cgagaactat taagacacat tattaggtat atattataaa aaagtttttg attacgatgt 11940 tataagagga aagaggacac attaacatca tacatcaatt aactacattc ttataacatc 12000 gtaatcaaaa gaattgcaat tttgatgtat aacaactgtc aatgggttat ggaattgtat 12060 attacatatt atacggtatg ttggtaacga caaataccga tcggtaattg tctgccggtg 12120 taatagaatt atatatatct atctattaca ccggccttgt atacataata ataagttgtg 12180 gtagtatgat ctccatattt ataatttagg actttgtatt cagttttttt ggaatcataa 12240 aaaataaaaa aaagttttac taatttaaaa ttatttacat ttttttcact gtttagtcgc 12300 ggatatggaa ttcgatcctg ccaaaatcaa tacatcatct atagatcatg taacaatatt 12360 acaatacata gatgaaccaa atgatataag actaacagta tgcattatca caaaaataaa 12420 tccacatttg gctaatcaat ttcgggcttg gaaaaaacgt atcgccggaa gggactatat 12480 gactaactta tctagagata caggaataca acaatcaaaa cttactgaaa ctgtcaaaaa 12540 aatagaaaca tatatggtct atatatacac tacaatttag ttattaattg gataaccgat 12600 gtgattatca atcaatatta agaaggttgg taaattggta catagctaat aatacctata 12660 cacccaataa tacaacaacc atttctgagt tggatatcat caaaatactg gataaatacg 12720 aggacgtgta tagagtaagt aaagaaaaag aatgtgaaat ttgctatgaa gttgtttact 12780 caaaacgata gatactttgg tttattggat tcgtgtaatc atatattttg cataacatgc 12840 atcaatatat ggcatagaac acgaagagaa accggtgcgt cggataattg tcctatatgt 12900 cgtacccgtt ttagaaacat aacaatgagc aagttaacta ataaataaaa agtttaattt 12960 gttgacgacg tatgtcgtta ttttttctcg tataaaagat taatttgatt ctaatataat 13020 ctttagtatt ggataaatat caattcaaat taattccatt agattatatc ataaataaaa 13080 atagtagcac gcactacttc agccaaatat tcttttttga aacgccatct atcgtagtga 13140 ggacacaagt gaacctataa tgagcaaatt tattagtatc ggttacatga aggactttac 13200 gtagagtggt gattccacta tctgtggtac gaacggtttc atcttctttg atgccatcac 13260 ccagatgttc tataaacttg gtatcctttg ccaaccaata catatagcta aactcaggca 13320 tatgttccac acatcctgaa caatgaaatt ctccagaaga tgttacaatg tctagatttg 13380 gacatttggt ttcaaccgcg ttaacatatg agtgaacaca cccatacatg aaagcgatga 13440 gaaataggat tttcatcttg ccaaaatatc actagaaaaa at ttatttat caattttaaa 13500 ggtataaaaa atacttattg ttgctcgaat attttgtatt tgatggtata cggaagatta 13560 gaaatgtagg tattatcatc aactgattct atggttttat gtattctatc atgtttttt tattctatc atgtttttt tggattattatagt attatttt 13620 atttgc tactcacgta attctggatt attgacatat ctatgaataa ttttagctcc atgatcagta 13740 aatattaatg agaacatagt attaccacct accattattt ttttcatctc attcaattct 13800 taattgcaaa gatctatata atcattatag cgttgactta tggactctgg aatcttagac 13860 gatgtacagt catctataat catggcatat ttaatacatt gttttatagc atagtcgtta 13920 tctacgatgt tagatatttc tctcaatgaa tcaatcacac aatctaatgt aggtttatga 13980 cataatagca ttttcagcag ttcaatgttt ttagattcgt tgatggcaat ggctatacat 14040 gtatatccgt tatttgatct aatgttgaca tctgaaccgg attctagcag taaagatact 14100 agagattgtt tattatatct aacagccttg tgaagaagtg tttctcctcg tttgtcaatc 14160 atgttaatgt ctttaagata aggtaggcaa atgtttatag tactaagaat tgggcaagca 14220 taagacatgt cacaaagacc ctttttgtat gtataagtgt aaaaattata acattcatag 14280 ttggatttac ataggtgtcc aatcgggatc tctccatcat cgagataatt gatggcatct 14340 cccttccttt tttagtagat atttcatcgt gtaagaatca atattaatat ttctaaagta 14400 tccgtgtata gcctctttat ttaccacagt tccatattcc actagaggga tatcgccgaa 14460 tgtcatatac tcaattagta tatgttggag gacatccgag ttcattgttt tcaatatca a 14520 aaagatggtt tccttatcat ttctccatag tggtacaata ctacacatta ttccgtgcgg 14580 ctttccattt tccaaaaaca atttgaccaa atctacatct ttattgtatc tataatcact 14640 atttagataa tcagccataa ttactcgagt gcaacatgtt agatcgtcta tatatgaata 14700 agccgtgtta tctattcctt tcattaacaa tttaacgatg tctatatcta tatgagatga 14760 cttaatataa tattgaagag ctgtacaata gtttttatct ataaaagacg gcttgattcc 14820 gtgattaatt agacatttaa caacttccgg acgcacatat gctctcgtat ccgactctga 14880 atacagatga gagatgatat acagatgcaa tacggtaccg caatttcgta gttgataatc 14940 atcatacgcg tatcagtact cgtcctcata aagaacactg cagccatttt ctatgaacaa 15000 atcaataatt tcaggaacag gatcatctgt cattacataa ttttctataa ctgaacgatg 15060 gttttcacat ttaacactca agtcaaatcc atgttctacc aacaccttta tcaagtcaac 15120 gtctacattt ttggatttca tatagctgaa tatattaaag tcatttatgt tgctaaatcc 15180 agtggcttct agtagagcca tcgctatatc ctttaacttt aacatgtcta ctatttgtgt 15240 attcttctaa tggggtagct gtctccaatt tttgcgtaat ggattagtgc cactgtctag 15300 tagtagtttg acgacctcga cattattaca atgctcatta aaaaggtatg c gtgtaaagc 15360 attattcttg aattggttcc tggtatcatt aggatctctg tctctcaaca tctgtttaag 15420 ttcatcgaga gccacctcct cattttccaa atagtcaaac attttgactg aatgagctac 15480 tgtgaactct atacacccac acaactaatg tcattaaata tcatgtcaaa aacttgtaca 15540 attattaata aaaataattt agtgtttaaa ttttaccagt tccagatttt acacctccgt 15600 taaccccact ttttacacca ctggacgatc ctcctcccca cattccaccg ccaccagatg 15660 tataagtttt agatccttta ttactaccat catgtccatg gataaagaca ctccacatgc 15720 cgccactacc ccctttagaa gacatattaa taagacttaa ggacaagttt aacaataaaa 15780 ttaatcacga gtaccctact accaacctac actattatat gattatagtt tctattttta 15840 cagtacctta actaaagtct ctagtcacaa gagcaatact accaacctac actattatat 15900 gattatagtt tctattttta taggaacgcg tacgagaaaa tcaaatgtct aatttctaac 15960 ggtagtgttg ataaacgatt atcgtcaatg gatacctcct ctatcatgtc gtctattttc 16020 ttactttgtt ctattaactt attagcatta tatattattt gattataaaa cttatattgc 16080 ttattagccc aatctgtaaa tatcggatta ttaacatatc gtttctttgt aggtttattt 16140 aacatgtaca tcactgtaag catgtccgta ccatttattt taat ttgacg catatccgca 16200 atttcttttt cgcagtcggt tataaattct atatatgatg gatacatgct acatgtgtac 16260 ttataatcga ctaatatgaa gtacttgata catattttca gtaacgattt attattacca 16320 cctatgaata agtacctgtg atcgtctagg taatcaactg ttttcttaat acattcgatg 16380 gttggtaatt tactcagaat aatttccaat atcttaatat ataattctgc tatttctggg 16440 atatatttat ctgccagtat aacacaaata gtaatacatg taaacccata ttttgttatt 16500 atattaatgt ctgcgccatt atctattaac cattctacta ggctgacact atgcgactta 16560 atacaatgat aaagtatact acatccatgt ttatatcatc aatatacggc ttacaaagtt 16620 ttagtatcga taacacatcc aactcacgca tagagaaggt agggaataat ggcataatat 16680 ttattaggtt atcatcattg tcattatcta caactaagtt tccatttttt aaaatatact 16740 cgacaacttt aggatctcta ttgccaaatt tttgaaaata tttatttata tgcttaaatc 16800 tatataatgt agctccttca tcaatcatac atttaataac attgatgtat actgtatgat 16860 aagatacata ttctaacaat agatcttgta tagaatctgt atatctttta agaattgtgg 16920 atattattac gtaaactatt acacaattct aaaatataaa acgtatcacg gtcgaataat 16980 agttgatcaa ctatataatt atcgattttg tgatttt tct tcctaaactg tttacgtaaa 17040 tagttagata gaatattcat tagttcatga ccactatagt tactatcgaa taacgcgtca 17100 aatatttccc gtttaatatc gcatttgtca agataataat agagtgtggt atgttcacga 17160 taagtataat aacgcatctc tttttcgtgt gaaattaaat agtttattac gtccaaagat 17220 gtagcataac catcttgtga cctagtaata atataataat agagaactgt tttacccatt 17280 ctatcatcat aatcagtggt gtagtcgtaa tcgtaattgt ctaattcatc atcccaatta 17340 taatattcac cagcacgtct aatctgttct attttgatct tgtatccata ctgtatgttg 17400 ctacatgtag gtattccttt atccaataat agtttaaaca catctacatt gggatttgat 17460 gttgtagcgt atttttctac aatattaata ccatttttga tactatttat ttctatacct 17520 ttcgaaatta gtaatttcaa taagtctata tcgatgttat cagaacatag atattcgagt 17580 atatcaaaat cattgatatt tttatagtcg actgacgaca ataacaaaat cacaacatcg 17640 tttttgatat tattattttt cttggtaacg tatgccttta atggagtttc accatcatac 17700 tcatataatg gatttgcacc actttctatc aatgattgtg cactgctggc atcgatgtta 17760 aatgttttac aactatcata gagtatctta tcgttaacca tgattggttg ttgatgctat 17820 cgcatttttt ggtttctttc atttcagtta tgtatggatt tagcacgttt gggaagcatg 17880 agctcatatg atttcagtac tgtagtgtca gtactattag tttcaataag atcaatctct 17940 agatctatag aatcaaaaca cgataggtca gaagataatg aatatctgta ggcttcttgt 18000 tgtactgtaa cttctcgttt tgttagatgt ttgcatcgtg ctttaacatc aatggtacaa 18060 attttatcct cgctttgtgt atcatattcg tccctactat aaaattgtat attcagatta 18120 tcatgagatg tgtatacgct aacggtatca ataaacggag cacaccattt agtcataacc 18180 gtaatccaaa aatttttaaa gtatatctta acgaaagaag ttgtgtcatt gtctacggtg 18240 tatggtacta gatcctcata agtgtatata tctagagtaa tgtttaattt atcaaatggt 18300 tgataatatg gatcctcatg acaatttccg aagatggaaa tgagatatag acatgcaata 18360 aatctaattg cggacatggt tactccttaa aaaaatacga ataatcacct tggctattta 18420 gtaagtgtca tttaacacta tactcatatt aatccatgga ctcataatct ctatacggga 18480 ttaacggatg ttctatatac ggggatgagt agttttcttc tttaacttta tactttttac 18540 taatcatatt tagactgatg tatgggtaat agtgtttaaa gagttcgttc tcatcatcag 18600 aataaatcaa tatctctgtt tttttgttat acagatgtat tacagcctca tatattacgt 18660 aatagaacgt gtcatctacc tt attaactt tcaccgcata gttgtttgca aatacggtta 18720 atcctttgac ctcgtcgatt tccgaccaat ctgggcgtat aatgaatcta aactttaatt 18780 tcttgtaatc attcgaaata atttttagtt tgcatccgta gttatcccct ttatgtaact 18840 gtaaatttct caacgcgata tctccattaa taatgatgtc gaattcgtgc tgtataccca 18900 tactgaatgg atgaacgaat accgacggcg ttaatagtaa tttacttttt catctttaca 18960 tattgggtac tagttttact atcataagtt tataaattcc acaagctact atggaataag 19020 ccaaccatct tagtataaca cacatgtctt aaagtttatt aattaattac atgttgtttt 19080 atatatcgct acgaatttaa acagagaaat cagtttagga aaaaaaaata tctatctaca 19140 tcatcacgtc tctgtattct acgatagagt gctactttaa gatgagacat atccgtgtca 19200 tcaaaaatat actccattaa aatgattatt ccggcagcga acttgatatt ggatatatca 19260 caacctttgt taatatctac gacaatagac agcagtccca tggttccata aacagtgagt 19320 ttatctttct ttgaagagat attttgtaga gatcttataa aactgtcgaa tgacatcgca 19380 tttatatctt tagctaaatc gtatatgtta ccatcgtaat atctaaccgc gtctatctta 19440 aacgtttcca tcgctttaaa gacgtttccg atagatggtc tcatttcatc agtcatactg 19500 agccaacaaa tataa tcgtg tataacatct ttgatagaat cagactctaa agaaaacgaa 19560 tcggctttat tatacgcatt catgataaac ttaatgaaaa atgtttttcg ttgtttaagt 19620 tggatgaata gtatgtctta ataattgtta ttatttcatt aattaatatt tagtaacgag 19680 tacactctat aaaaacgaga atgacataac tagttatcaa agtgtctagg acgcgtaatt 19740 ttcatatggt atagatcctg taagcattgt ctgtattctg gagctatttt ctctatatct 19800 aatttctgaa cgttcaccaa tgtctctagc cactttggca ctaatagcga tcattcgctt 19860 agcgtcttct atattattaa ctggttgatt caatctatct agcaatggac cgtcggacag 19920 cgtcattctc atgttcttaa tcaatgtaca tacatcgccg tcatctacca attcatccaa 19980 caacataagc tttttaaaat catcattata ataggtttga tcgttgtcat ttctccaaag 20040 aatatatcta ataagtagag tcctcatgat tagttaacaa ctatttttta tgttaaatca 20100 attagtacac cgctatgttt aatacttatt catattttag tttttaggat tgagaatcaa 20160 tacaaaaatt aatgcatcat taattttaga aatacttagt ttccacgtag tcaatgaaac 20220 atttgaactc atcgtacagg acgttctcgt acaggacgta actataaacc ggtttatatt 20280 tgttcaagat agatacaaat ccgataactt tttttacgaa ttctacggga tccactttaa 20340 aagtgtca ta ccgggttctt tttatttttt taaacagatt aatggtgtga tgttgattag 20400 gtcttttacg aatttgatat agaatagcgt ttacatattc tccataatgg tcaatcgcca 20460 tttgttcgta tgtcataaat tctttaatta tatgacactg tgtattattt agttcatcct 20520 tgttcatcat taggaatcta tccaatatgg caattatact agaactatag gtgcgttgta 20580 tacacatatt gatgtgtctg tttatacaat ccatgctact accttcgggt aaaattgtag 20640 catcatatac catttctagt actttaggtt cattgttatc cattgcagag gacgtcatga 20700 tcgcatccta aaaaaatata ttatttttat gttattttgt taaaaataat catcgaatac 20760 gaatcatcca gtccactgaa tagcaaaatc tttactattt tggtatcttc caatgtggct 20820 gcctgatgta atggaaattc attctctaga agatttttca atgctccagc gttcaacaac 20880 gtacatacta gacgcacgtt attatcagct attgcataat acaaggcact atgtccatgg 20940 acatccgcct taaatgcatc tttgctagag agaaagcttt tcagctgctt agacttccaa 21000 gtattaattc gtgacagatc catgtctgaa acgagacgct aattagtgta taatttttgt 21060 catattgcac cagaattaat aatatctcta atagatctga ttagtagata catggctatc 21120 gcaaaacaac atatacacat ttaataaaaa taatatttat taagaaaatt cagatttcac 21180 gtacccatca atataaataa aataatgatt ccttacaccg tacccatatt aaggagattc 21240 taccttaccc ataaacaata taaatccagt aatatcatgt ctgatgatga acacaaatgg 21300 tgtattaaat tccagttttt caggagatga tctcgccgta gctaccataa tagtagatgc 21360 ctctgctaca gttccttgtt cgtcgacatc tatctttgca ttctgaaaca ttttataaat 21420 atataatggg tccctagtca tatgtttaaa cgacgcatta tctggattaa acatactagg 21480 agccatcatt tcggctatcg acttaatatc cctcttattt tcgatagaaa atttagggag 21540 tttaagattg tacactttat tccctaattg aaacgaccaa tagtctaatt ttgcagccgt 21600 aatagaatct gtgaaatggg tcatattatc acctattgcc aggtacatac taatattagc 21660 atccttatac ggaaggcgta ccatgtcata ttctttgtca tcgattgtga ttgtatttcc 21720 ttgcaattta gtaactacgt tcatcatggg aaccgttttc gtaccgtact tattagtaaa 21780 actagcattg cgtgttttag tgatatcaaa cggatattgc catatacctt taaaatatat 21840 agtattaatg attgcccata gagtattatt gtcgagcata ttagaatcta ctacattaga 21900 cataccggat ctacgttcta ctatagaatt aattttatta accgcatctc gtctaaagtt 21960 taatctatat aggccgaatc tatgatattg ttgataatac gacggtttaa tacacacag t 22020 attatctacg aaactttgat aagttagatc agtgtacgta tatttagatg ttttcagctt 22080 agctaatcct gatattaatt ctgtaaatgc tggacccaga tctctttttc tcaaatccat 22140 agtcttcaat aattctattc tagtattacc tgatgcaggc aatagcgaca taaacataga 22200 aaacgaataa ccaaacggtg agaagacaat attatcatct tgaatatttt tatacgctac 22260 tataccggca ttggtaaatc cttgtagacg ataggtagac gctgaacacg ttaacgatag 22320 tatcaataac gcaatcatga ttttatggta ttaataatta accttatttt tatgttcggt 22380 ataaaaatta ttgatgtcta cacatccttt tgtaattgac atctatatat ccttttgtat 22440 aatcaactct aatcacttta acttttacag ttttccctac cagtttatcc ctatattcaa 22500 catatctatc catatgcatc ttaacactct ctgccaagat agcttcagag tgaggatagt 22560 caaaaagata aatatataga gcataatcat tctcgtatac tctgcccttt attacatcgc 22620 ccgcattggg caacgaataa caaaatgcaa gcatcttgtt aacgggctcg taaattggga 22680 taaaaattat gtttttatat ctattttatt caagagaata ttcaggaatt tctttttccg 22740 gttgtatctc atcgcagtat atatcatttg tacattgttt catatttttt aatagtttac 22800 accttttagt aggactagta tcgtacaatt catagctgta ttttgaattc c aatcacgca 22860 taaaaatatc ttctaattgt tgacgaagac ctaatccatc atccggtgta atattaatag 22920 atgctccaca tgtatccgta aagtaatttc ctgtccaatt tgaggtacct atataggccg 22980 ttttatcggt taccatatat ttggcatggt ttaccctaga atacggaatg ggaggatcag 23040 catctggtac aataaatagc tttacttcta tatttatgtt tttagatttt agcatagcga 23100 tagatcttaa aaagtttctc atgataaacg aagatcgttg ccagcaacta atcaatagct 23160 taacggatac ttgtctgtct atagcggatc ttcttaattc atcttctata taaggccaaa 23220 acaaaatttt acccgccttc gaataaataa tagggataaa gttcataaca gatacataaa 23280 cgaatttact cgcatttcta atacatgaca ataaagcggt taaatcattg gttctttcca 23340 tagtacatag ttgttgcggt gcagaagcaa taaatacaga gtgtggaaca ccacttacgt 23400 taatactaag aggatgatct gtattataat acgacggata aaagtttttc caattatatg 23460 gtagattgtt aactccaaga taccagtata cctcaaaaat ttgagtgaga tccgctgcca 23520 agttcctatt attgaagatc gcaataccca attctttgac ctgagttagt gatctccaat 23580 ccatgttagc gcttcctaaa taaatatgtg tattatcaga tatccaaaat tttgtatgaa 23640 gaactcctcc taggatattt gtaatatcta tgtatcgtac ttca actccg gccatttgta 23700 gtctttcaac atcctttaat ggtttgttag atttattgac ggctactcta actcgtactc 23760 ctcttttggg taattgtaca atctcgttta atattatcgt gccgaaattc gtacccactt 23820 catccgataa actccaataa aaagatgata tatctagtgt ttttgtggta ttggatagaa 23880 tttccctcca catgttaaat gtagacaaat atactttatc aaattgcata cctataggaa 23940 tagtctctgt aatcactgcg attgtattat ccggattcat tttatttgtt aaaagaataa 24000 tcctatatca cttcactcta ttaaaaatcc aagtttctat ttctttcatg actgattttt 24060 taacttcatc cgtttcctta tgaagatgat gtttggcacc ttcataaatt tttatttctc 24120 tattacaatt tgcatgttgc atgaaataat atgcacctaa aacatcgcta atctcattgt 24180 ttgttccctg gagtatgaga gtcggggtgt taatcttgga aattattttt ctaaccttgt 24240 tggtagcctt caagacctga ctagcaaatc cagccttaat tttttcatga ttgattaatg 24300 ggtcgtattg gtatttataa actttatcca tatctctaga tactgattct ggacatagct 24360 ttccgactgg cgcatttggt gtgatggttc ccataagttt ggcagctagc agattcagtc 24420 ttgaaacagc atctgcatta actagaggag acattagaat cattgctgta aacaagtttg 24480 gattatcgta agaggctagt atagaaattg ttgctcc cat ggaatgaccc aataagtaga 24540 tttaatagtt accacgtgct gtaccaaagt catcaatcat cattttttca ccattacttc 24600 ttccatgtcc aatatgatca tgtgagaata ctaaaattcc taacgatgat atgttttcag 24660 ctagttcgtc ataacgtcca gaatgtttac cagctccatg acttatgaat actaatgcct 24720 taggatatgt aatcattgtc cagattgaac atacagtttg cactcatgat tcacgttata 24780 taactatcaa tattaacagt tcgtttgatg atcatattat ttttatgttt tattgataat 24840 tgtaaaaaca tacaattaaa tcaatataga ggaaggagac ggctactgtc ttttgtgaga 24900 tagtcatggc gactaaatta gattatgagg atgctgtttt ttactttgtg gatgatgata 24960 aaatatgtag tcgcgactcc atcatcgatc taatagatga atatattacg tggagaaatc 25020 atgttatagt gtttaacaaa gatattacca gttgtggaag actgtacaag gaattgatga 25080 agttcgatga tgtcgctata cggtactatg gtattgataa aattaatgag attgtcgaag 25140 ctatgagcga aggagaccac tacatcaatt ttacaaaagt ccatgatcag gaaagtttat 25200 tcgctaccat aggaatatgt gctaaaatca ctgaacattg gggatacaaa aagatttcag 25260 aatctagatt ccaatcattg ggaaacatta cagatctgat gaccgacgat aatataaaca 25320 tcttgatact ttttctagaa aaaaaattga attgatgata taggggtctt cataacgcat 25380 aattattacg ttagcattct atatccgtgt taaaaaaaat tatcctatca tgtatttgag 25440 agttttatat gtagcaaaca tgatagctgt gatgccaata agctttagat attcacgcgt 25500 gctagtgtta gggatggtat tatctggtgg tgaaatgtcc gttatataat ctacaaaaca 25560 atcatcgcat atagtatgcg atagtagagt aaacattttt atagttttta ctggattcat 25620 acatcgtcta cccaattcgg ttatgaatga aattgtcgcc aatcttacac ccaacccctt 25680 gttatccatt agtatagtat taacttcgtt atttatgtca taaactgtaa atgattttgt 25740 agatgccata tcatacatga tattcatgtc cctattataa tcattactaa ctttatcaca 25800 atatatgttg ataatatcta tatatgatct agtctttgtg ggcaactgtc tatacaagtc 25860 gtctaaacgt tgtttactca tatagtatcg aacagccatc attacatggt cccgttccgt 25920 tgatagataa tcgagtatgt tagtggactt gtcaaatcta tataccatat tttctggaag 25980 tggatataca tagtcgtgat caacattatt gctagcctca tcttctatat cctgtactat 26040 accatctaca taatctacga tattattaca cataaacatc gacaacatac tattgtttat 26100 tatctaagtc ctgttgatcc aaacccttga tctcctctat ttgtactatc tagagattgt 26160 acttcttcca gttctggata at atatacgt tgatagatta gctgagctat tctatctcca 26220 gtatttacat taaacgtaca ttttccatta ttaataagaa tgactcctat gtttccccta 26280 taatcttcgt ctattacacc acctcctata tcaatgcctt ttagtgacag accagaccta 26340 ggagctattc taccatagca aatcttaggc atggacatac taatatctgt cttaattaac 26400 tgtctttctc ctggagggat agtataatcg taagcgctat acaaatcata tccggcagca 26460 cccggcgatt gcctagtagg agatttagct ctgttagttt ccttaacaaa tctaactggt 26520 gagttaatat tcatgttgaa cataaaacta atattttatt tcaaaattat ttaccatccc 26580 atatattcca tgaataagtg tgatgattgt acacttctat agtatctata tacgattcac 26640 gataaaatcc tcctatcaat agcagtttat tatccactat gatcaattct ggattatccc 26700 tcggataaat aggatcatct atcagagtcc atgtattgct ggattcacaa taaaattccg 26760 catttctacc aaccaagaat aaccttctac cgaacactaa cgcgcatgat ttataatgag 26820 gataataagt ggatggtcca aactgccact gatcatgatt gggtagcaaa tattctgtag 26880 ttgtatcagt ttcagaatgt cctcccatta cgtatataac attgtttatg gatgccactg 26940 ctggattaca tctaggtttc agaagactcg gcatattaac ccaagcagca tccccgtgga 27000 accaacgctc aacag atgtg ggatttggta gacctcctac tacgtataat ttattgttag 27060 cgggtatccc gctagcatac agtctggggc tattcatcgg aggaattgga atccaattgt 27120 ttgatatata atttacagct atagtacattacgt tatgtattatttt tacctatacgt tatgtattatttc tacctata 27ttcat gatccatgtt cataggatac tctatgaatg gatacttgta tgatttgcgt ggttgtttat 27300 cacaatgaaa tattttggta cagtctagta tccattttac attatttata cctctgggag 27360 aaagataatt tgacctgatt acatttttga taaggagtag cagatttcct aatttatttc 27420 ttcgctttat ataccactta atgacaaaat cctcatctgg aacatttagt tcatcgcttt 27480 ctagaataag tttcatagat agataatcaa aattgtctat gatgtcatct tccagttcca 27540 aaaagtgttt ggcaataaag tttttagtat gacataagag attggatagt ccgtattcta 27600 tacccatcat gtaacactcg acacaatatt cctttctaaa atctcgtagg ataaagttta 27660 tacaagtgta gatgataaat tctacagagg ttaatataga agcacgtaat aaattgacga 27720 cgttatgact atctatatat acctttccag tatatgagta aataactata gaagttagac 27780 tgtgaatgtc aaggtctaga caaaccctcg taactggatc tttatttttc gtgtattttt 27840 gacgtaaatg tgtgcgaaag taaggagata actttttcaa tatcgtagaa ttgactatta 27900 tattgcctcc tatggcatca ataattgttt tgaatttctt agtcatagac aatgctaata 27960 tattcttaca gtacacagta ttgacaaata tcggcattta tgtttcttta aaagtcaaca 28020 tctaaagaaa aatgattatc ttcttgagac ataactccca ttttttggta ttcacccac a 28080 cgtttttcga aaaaattagt tttaccttct aatgatatat tttccatgaa atcaaacgga 28140 ttggtaacat tataaatttt tttaaatccc aattcagaaa tcaatctatc cgcgacgaat 28200 tctatatatg ttttcatcat ttcacaattc attcctataa gtttaactgg aagagccgca 28260 gtaagaaatt cttgttcaat ggataccgca tctgttataa tagatctaac ggtttcttca 28320 ctcggtggat gcaataaatg tttaaacatc aaacatgcga agtcgcagtg tagaccctcg 28380 tctctactaa tcaattcgtt ggaaaacgtg agtccgggca ttaggccacg ctttttaagc 28440 caaaatatgg aagcgaatga tccggaaaag aagattcctt ctactgcagc aaaggcaata 28500 agtctctctc cataaccggc gctgtcatgt atccactttt gagcccaatc ggccttcttt 28560 tttacacaag gcatcgtttc tatggcatta aagagatagt ttttttcatt actatcttta 28620 acataagtat cgatcaaaag actatacatt tccgaatgaa tgttttcaat ggccatctga 28680 aatccgtaga aacatctagc ctcggtaatc tgtacttctg tacaaaatcg ttccgccaaa 28740 ttttcattca ctattccgtc actggctgca aaaaacgcca atacatgttt tataaaatat 28800 ttttcgtctg gtgttagttt attccaatca ttgatatctt tagatatatc tacttcttcc 28860 actgtccaaa atgatgcctc tgccttttta tacatgttcc agatgtcatg a tattggatt 28920 gggaaaataa caaatctatt tggatttggt gcaaggatgg gttccataac taaattaaca 28980 ataacaataa attttttttc agttatctat atgcctgtac ttggatcttt tgtacatcga 29040 tatcgccgca atcactacaa taattacaag tattattgat agcattgtta ttagtactat 29100 cataattaaa ttatcgttat tatcattttg taattgtgac atcatactag ataaatcgtt 29160 tgcgagattg ttgtgggaag cgggcatgga ggatgaatta tcgttattat tatttaaagc 29220 ctcccattcg gattcacaaa tatggcgcgc gttcaacatt ttatggaaac agataacaag 29280 aaaactcgtc atcgttcaaa tttttaacga tagtaaaccg attaaacgtc gagctaattt 29340 ctaacgctag cgactctgtt ggatatgggt ttccagatat atatcttttc agttccccta 29400 cgtatctata atcatctgta ggaaatggaa gatatttcca tttatctact gttcctaata 29460 tcatatgtgg tggtgtagta gaaccattaa gcgcgaaaga tgttatttcg catcgtattt 29520 taacttcgca ataatttctg gttagataac gcactctacc agtcaagtca atgatattag 29580 cctttacaga tatattcata gtagtcgtaa cgatgactcc atcttttaga tgcgatactc 29640 ctttgtatgt accagaatct tcgtacctca aactcgatat atttaaacaa gttaatgaga 29700 tattaacgcg ttttatgaat gatgatatat aaccagaagt ttta tcctcg gtggctagcg 29760 ctataacctt atcattataa taccaactag tgtgattaat atgtgacacg ttagtgtggg 29820 tacaaatatg tacattatcg tctacgtcgt attcgataca tccgcataca gccaacaaat 29880 ataaaatgac aaatactcta acgccgttcg tacccatctt gatgcggttt aataaatgtt 29940 ttgatttcaa tttattgtaa aaaaagattc ggttttatac tgttcgatat tctcattgct 30000 tatattttca tctatcatct ccacacagtc aaatccgtgg ttagcatgca cctcatcaac 30060 cggtaaaaga ctatcggact cttctatcat tataactcta gaatatttaa tttggtcatt 30120 attaatcaag tcaattatct tatttttaac aaacgtgagt attttactca ttttttataa 30180 aaacttttag aaatatacag actctatcgt gtgtctatat cttcttttta tatccaatgt 30240 atttatgtct gatttttctt catttatcat atataatggt ccaaattcta cacgtgcttc 30300 ggattcatcc agatcattaa ggttcttata attgtaacat ccttctcttc cctcttctac 30360 atcttccttc ttattcttat tcttagcgtc acagaatcta ccacagcagg atcccatgac 30420 gagcgtcata ttaaactaat ccattttcaa ttataatata cgattagtaa tgaccattaa 30480 aataaaaata ttcttcataa ccggcaagaa agtgaaaagt tcacattgaa actatgtcag 30540 tagtatacat catgaaatga tgatatatat atactct att ttggtggagg attatatgat 30600 ataattcgtg gataatcatt cttaagacac atttcttcat tcgtaaatct tttcacgtta 30660 aatgagtgtc catattttgc aatttcttca tatgatggcg gtgtacgtgg acgaggctgc 30720 tcctgttctt gttgtagtcg ccgactgtcg tgtctgcgtt tagatccctc cattatcgcg 30780 attgcgtaga tggagtacta ttttatacct tgtaattaaa tttttttatt aattaaacgt 30840 ataaaaacgt tccgtatctg tatttaagag ccagatttcg tctaatagaa caaatagcta 30900 cagtaaaaat aactagaata attgctacac ccactagaaa ccacggatcg taatacggca 30960 atcggttttc gataataggt ggaacgtata ttttatttaa ggacttaaca attgtctgta 31020 aaccacaatt tgcttccgcg gatcctgtat taactatctg taaaagcata tgttgaccgg 31080 gcggagccga acattctccg atatccaatt tctgtatatc tataatatta ttaacctccg 31140 catacgcatt acagttcttt tctagcttgg ataccgcact aggtacatcg tctagatcta 31200 ttcctatttc ctcagcgata gctcttctat ccttttccgg aagcaatgaa atcacttcaa 31260 taaatgattc aaccatgagt gtgaaactaa gtcgagaatt actcatgcat ttgttagtta 31320 ttcggagcgc gcaattttta aactgtccta taacctctcc tatatgaata gcacaagtga 31380 cattagtagg gatagaatgt tgagctaatt tttgtaaata actatctata aaaagattat 31440 acaaagtttt aaactcttta gtttccgcca tttatccagt ctgagaaaat gtctctcata 31500 ataaattttt ccaagaaact aattgggtga agaatggaaa cctttaatct atatttatca 31560 cagtctgttt tggtacacat gatgaattct tccaatgccg tactaaattc gatatctttt 31620 tcgatttctg gatatgtttt taataaagta tgaacaaaga aatggaaatc gtaataccag 31680 ttatgtttaa ctttgaaatt gttttttatt ttcttgttaa tgattccagc cacttgggaa 31740 aagtcaaagt cgtttaatgc cgatttaata cgttcattaa aaacaaactt tttatccttt 31800 agatgaatta ttattggttc attggaatca aaaagtaaga tattatcggg tttaagatct 31860 gcgtgtaaaa agttgtcgca gcatggtagt tcgtaaattt taatgtataa cagagccatc 31920 tgtaaaaaga taaactttat gtattgtacc aaagatttaa atcctaattt gatagctagc 31980 tcggtatcta ctttatctgc cgaatacagt gctaggggaa aaattataat atttcctctt 32040 tcgtattcgt agttagttct cttttcatgt tcgaaaaagt gaaacatgcg gttaaaatag 32100 tttataacat taatattact gttaataact gccggataaa agtgggatag taatttcacg 32160 aatttgatac tgtcctttct ctcgttaaac gcctttaaaa aaactttaga agaatatctc 32220 aatgatagtt cctgaccatc ca tagtttgt atcaataata gcaacatatg aagaacacgt 32280 ttatacagag tatgtaaaaa tgttaattta tagtttaatc ccatggccca cgcacacacg 32340 attaattttt tttcatctcc ctttagattg ttgtatagaa atttgggtac tgtgaactcc 32400 gccgtagttt ccatgggact atataatttt gtggcctcga atacaaattt tactacatag 32460 ttatctatct taaagactat accatatcct cctgtagata tgtgataaaa atcgtcgttt 32520 ataggataaa atcgtttatc cttttgttgg aaaaaggatg aattaatgta atcattctct 32580 tctatcttta gtagtgtttc cttattaaaa ttcttaaaat aatttaacaa tctaactgat 32640 ggagcccaat tttggtgtaa atctaattgg gacattatat tgttaaaata caaacagtct 32700 cctaatataa cagtatctga taatctatgg ggagacatcc attgatattc aggggatgaa 32760 tcattggcaa cacccattta ttgtacaaaa agccccaatt tacaaacgaa agtccaggtt 32820 tgatagagac aaactattaa ctattttgtc tctgttttta atttctttgg taatgaaatt 32880 attcacaata tcagtatctt ctttatctac cagagatttt actaacttga taaccttggc 32940 tgtctcattc aatagggtag taatatttgt atgtgtgata ttgatatctt ttagaagtga 33000 ttctttgatg gtgccagcat acgaattaca ataatgcaga aactcggtta acatgcagga 33060 attatagtaa gccaa ttcca attgttgcct gtgttgtatt agagtgtcaa tatgagcaat 33120 ggtgtccttg cgtttctctg atagaatgcg agcagcgatt ttggcgttat catttgacga 33180 tatttctgga atgacgaatc ctgtttctac taactttttg gtaggacaaa gtgaaacaat 33240 caagaagata gcttctcctc ctatttgtgg aagaaattga actcctctag atgatctcct 33300 tgacagatat tggaccgaat tacagaagta cctggaatgt aaagccctga aaccccctca 33360 ttttttaagc agattgttgc cgtaaatcct gcactatgcc caagatagag agctcctttg 33420 gtgaatccat ctctatgttt cagtttaacc aagaaacagt cagctggtct aaaatttcca 33480 tctctatcta atacagcatc taacttgatg tcaggaacta tgaccggtta tgttatatgt 33540 aacattgagt aaatccttaa gttcataatc atcactgtca tcagttatgt acgatccaaa 33600 caatgtttct actggcatag tggatacgaa gatgctatcc atcagaatgt ttccctgatt 33660 agtattttct atatagctat tcttctttaa acgattttcc aaatcagtaa ctatgttcat 33720 ttttttagga gtaggacgcc tagccagtat ggaagaggat tttctagatc ctctcttcaa 33780 catctttgat ctcaatggaa tgcaaaaccc catagtgtaa caaccaacga taaaaataat 33840 attgtttttc actttttata attttaccat ctgactcatg gattcattaa tatctttata 33900 agagctac ta acgtataatt ctttataact gaactgagat atatacaccg gatctatggt 33960 ttccataatt gagtaaatga atgctcggca ataactaatg gcaaatgtat aaaacaacga 34020 aattatacta gagttgttaa agttaatatt ttctatgagc tgttccaata aattatttgt 34080 tgtaactgcg ttcaagtcat aaatcatctt gatactatcc agtaaaccgt ttttaagttc 34140 tggaatatta ttatcccatt gtaaagcccc taattcgact atcgaatatc ctgctctgat 34200 agcagtttca atatcgacgg acgtcaatac tgtaataaag gtggtagtat tgtcatcatc 34260 gtgataaact actggaatat ggtcgttagt aggtacggta actttacaca acgcgatata 34320 taactttcct tttgtaccat ttttaacgta gttgggacgt cctgcagggt attgttttga 34380 agaaatgata tcgagaacag atttgatacg atatttgttg gattcctgat tatttactat 34440 aatataatct agacagatag atgattcgat aaatagagaa ggtatatcgt tggtaggata 34500 atacatcccc attccagtat tctcggatac tctattaatg acactagtta agaacatgtc 34560 ttctattcta gaaaacgaaa acatcctaca tggactcatt aaaacttcta acgctcctga 34620 ttgtgtctcg aatgcctcgt acaaggattt caaggatgcc atagattctt tgaccaacga 34680 tttagaattg cgtttagcat ctgatttttt tattaaatcg aatggtcggc tctctggttt 34740 gctaccccaa tgataacaat agtcttgtaa agataaaccg caagaaaatt tatacgcatc 34800 catccaaata accctagcac catcggatga tattaatgta ttattataga ttttccatcc 34860 acagttattg ggccagtata ctgttagcaa cggtatatcg aatagattac tcatgtaacc 34920 tactagaatg atagttcgtg tactagtcat aatatcttta atccaatcta agaaatttaa 34980 aattagattt tttacactgt taaagttaac aaaggtatta cccggatacg tggatatcat 35040 atatggtatt ggtccattat cagtaatagc tccataaact gatacggcga tggtttttat 35100 atgtgtttga tctaacgagg aagaaattcg cgcccacaat tcatctctag atatgtattt 35160 aatatcaaac ggtaacacat caatttcggg acgcgtatat gtttctaaat ttttaatcca 35220 aatataatga tgacctatat gccctattat catactgtca actatagtac acctagagaa 35280 cttacgatac atctgtttcc tataatcgtt aaattttaca aatctataac atgctaaacc 35340 ttttgacgac aaccattcat taatttctga tatggaatct gtattctcaa taccgtatcg 35400 ttctaaagcc agtgctatat ctccctgttc gtgagaacgc tttcgtataa tatcgatcaa 35460 cggataatct gaagtttttg gagaataata tgactcatga tctatttcgt ccataaacaa 35520 tctagacata ggaattggag gcgatgatct taattttgtg caatgagtcg tcaatccta t 35580 aacttctaat attgtaatat tcatcatcga cataacacta tctatgttat catcgtatat 35640 tagtatacca tgaccttctt catttcgtgc caaaatgata tacagtctta aatagttacg 35700 caatatctca atagtttcat aattgttagc tgttttcatc aaggtttgta tcctgtttaa 35760 catgatggcg ttctatacgt ttctattttt taaattttta acgatttact gtggctagat 35820 acccaatctc tctcaaatat ttttttagcc tcgcttacaa gctgtttatc tatactatta 35880 aaactgacga atccgtgatt ttggtaatgg gttccgtcga aatttgccga agtgatatga 35940 acatattcgt cgtcgactat caacaatttt gtattattct gaatagtgaa aaccttcaca 36000 gatagatcat tttgaacaca caacgcgtct agacttctgg cggttgccat agaatatacg 36060 tcgttcttat cccaattacc aactagaagt ctgatcttaa ctcctctatt aatggctgct 36120 tctataatgg agttgtaaat gtcgggccaa tagtagctat taccgtcgac acgtgtagtg 36180 ggaactatgg ccaaatgttc aatatctata ctagtcttag ccgacttgag tttatcaata 36240 actacatcag tgtctagatc tctagaatat cccaataggt gttccggaga atcagtaaag 36300 aacactccac ctataggatt cttaatatga tacgcagtgc taactggcag acaacaagcc 36360 gcagagcata aattcaacca tgaatttttt gcgctattaa aggctttaaa a gtatcaaat 36420 cttctacgaa gatctgtggc cagcggggga taatcagaat atacacctaa cgttttaatc 36480 gtatgtatag atcctccagt aaatgacgcg tttcctacat aacatctttc attatctgac 36540 acccaaaaac aaccgagtag tagtcccaca ttattttttt tatctatatt aacggttata 36600 aaatttatat ccgggcagtg actttgtagc tctcccagat ttcttttccc tcgttcatct 36660 agcaaaacta ttattttaat ccctttttca gatgcctctt ttagtttatc aaaaataagc 36720 gctcccctag tcgtactcag aggattacaa caaaaagatg ctatgtatat atatttctta 36780 gctagagtga taatttcgtt aaaacattca aatgttgtta aatgatcgga tctaaaatcc 36840 atattttctg gtagtgtttc taccagccta cattttgctc ccgcaggtac cggtgcaaat 36900 ggccacattt agttaacata aaaacttata catcctgttc tatcaacgat tctagaatat 36960 catcggctat atcgctaaaa ttttcatcaa agtcgacatc acaacctaac tcagtcaata 37020 tattaagaag ttccatgatg tcatcttcgt ctatttctat atccgtatcc attgtagatt 37080 gttgaccgat tatcgagttt aaatcattac taatactcaa tccttcagaa tacaatctgt 37140 gtttcattgt aaatttatag gcggtgtatt taagttggta gattttcaat tatgtatcaa 37200 tatagcaaca gtagttcttg ctcctccttg attctagcat cctc ttcatt attttcttct 37260 acgtacataa acatgtccaa tacgttagac aacacaccga cgatggcggc cgccacagac 37320 acgaatatga ctaaaccgat gaccatttaa aaacccctct ctagctttca cttaaactgt 37380 atcgattatt cttttagaac atgtataata taaaaacatt attctatttc gaatttaggc 37440 ttccaaaaat ttttcatccg taaaccgata ataatatata tagacttgtt aatagtcgga 37500 ataaatagat taatgcttaa actatcatca tctccacgat tagagataca atatttacat 37560 tttttttgct gtttcgaaac tttatcaata cacgttaata caaacccagg aaggagatat 37620 tgaaactgag gctgttgaaa atgaaacggt gaatacaata attcagataa tgtaaaatca 37680 tgattccgta ttctgatgat attagaactg ctaatggatg tcgatggtat gtatctagga 37740 gtatctattt taacaaagca tcgatttgct aatatacaat tatcattttg attaattgtt 37800 attttattca tattcttaaa aggtttcata tttatcaatt cttctacatt aaaaatttcc 37860 atttttaatt tatgtagccc cgcaatactc ctcattacgt ttcatttttt gtctataata 37920 tccattttgt tcatctcggt acatagatta tccaattgag aagcgcattt agtagttttg 37980 tacattttaa gtttattgac gaatcgtcga aaactagtta tagttaacat tttattattt 38040 gataccctga tattaatacc cctgccgtta ctattat tta taactgatgt aatccacgta 38100 acattggaat taactatcga tagtaatgca tcgacgcttc caaaattgtc tattataaac 38160 tcaccgataa tttttttatt acatgttttc atattcatta ggattattaa atctttaatc 38220 ttactacgat tgtatgcgtt gatattgcaa gacgtcattc taaaagacgg aggatctcca 38280 tcaaatgcca gacaatcacg tacaaagtac atggaaatag gttttgttct attgcgcatc 38340 atagatttat atagaacacc cgtagaaata ctaatttgtt ttactctata aaatactaat 38400 gcatctattt catcgttttg tataacgtct ttccaagtgt caaattccaa atttttttca 38460 ttgatagtac caaattcttc tatctcttta actacttgca tagataggta attacagtga 38520 tgcctacatg ccgttttttg aaactgaata gatgcgtcta gaagcgatgc tacgctagtc 38580 acaatcacca ctttcatatt tagaatatat atatgtaaaa atatagtaga atttcatttt 38640 gttttttttc tatgctataa atgaattctc attttgcatc tgctcatact ccgttttata 38700 tcaataccaa agaaggaaga tatctggttc taaaagccgt taaagtatgc gatgttagaa 38760 ctgtagaatg cgaaggaagt aaagcttcct gcgtactcaa agtagataaa ccctcatcac 38820 ccgcgtgtga gagaagacct tcgtcccctt ccagatgcga gagaatgaat aacccaggaa 38880 aacaagttcc gtttatgagg acggacatgc tacaaaatat gttcgcggct aatcgcgata 38940 atgtagcttc tagacttttg tcctaaaata caattatatc cttttcgata ttaataaatc 39000 cgtgtcgtcc aggtttttta tctctttcag tatgtgaata gataggtatt ttatctctat 39060 tcatcatcga atttaagaga tccgataaac attgtttgta ttctccagat gtcagcatct 39120 gatacaacaa tatatgtgca cataaacctc tggcacttat ttcatgtacc ttccccttat 39180 cactaaggag aatagtattt gagaaatatg tatacatgat attatcatga attagatata 39240 cagaatttgt aacactctcg aaatcacacg atgtgtcggc gttaagatct aatatatcac 39300 tcgataacac attttcatct agatacacta gacatttttt aaagctaaaa tagtctttag 39360 tagtaacagt aactatgcga ttattttcat cgatgataca tttcatcggc atattattac 39420 gcttaccatc aaagactata ccatgtgtat atctaacgta ttctagcatg gttgccatac 39480 gcgcattaaa cttttcagga tctttggata gatcttccaa tctatctatt tgagaaaaca 39540 tttttatcat gttcaatagt tgaaacgtcg gatccactat atagatatta tctataaaga 39600 ttttaggaac tacgttcatg gtatcctggc gaatattaaa actatcaatg atatgattat 39660 cgttttcatc ttttatcacc atatagtttc taagatatgg gattttactt aatataatat 39720 tatttcccgt aataaatttt at tagaaatg ccaaatctat aagaaaagtc ctcgaattag 39780 tttgaagaat atctatatcg ccgtaccgta tatttggatt aattagatat agagaatatg 39840 atccgtaaca tatacaactt ttattatggc gtctaagata ttcttccatc aacttattaa 39900 catttttgac tagggaagat acattatgac gtcccattac ttttgccttg tctattactg 39960 cgacgttcat agaatttagc atatctcttg ccaattcttc cattgatgtt acattataag 40020 aaattttaga tgaaattaca tttggagctt taatagtaag aactcctaat atgtccgtgt 40080 atgtggtcac taatacagat tgtagttcta taatcgtaaa taatttacct atattatatg 40140 tttgagtctg tttagaaaag tagctaagta tacgatcttt tatttctgat gcagatgtat 40200 caacatcgga aaaaaatctt tttttattct tttttactaa agatacaaat atgtctttgt 40260 taaaaacagt tattttctga atatttctag cttgtaattt taacatatga tattcgttca 40320 cactaggtac tctgcctaaa taggtttcta taatctttaa tgtaatatta ggaaaagtat 40380 tctgatcagg attcctattc attttgagga tttaaaactc tgattattgt ctaatatggt 40440 ctcaacacaa actttttcac agagcgatag agtttttgat aactcgtttt tcttaagaaa 40500 tataaaacta ctgtctccag agctcgctct atcttttatt ttatttaatt cgatacaaac 40560 tcctgatact ggttc agaaa gtaattcatt aattttcagt cctttataga agatatttaa 40620 tatagataat acaaaatctt cagtttttga tatcgatctg attgatccta gaactagata 40680 tattaataac gtgctgctcatta ggcagtttat gatatta tagattt 740 tatttagtata tattga tatta aaataaatcc aaaataacta gacattctat tttttgtgga ttagtgtact ctcttccctc 40860 tatcatgttc actactggtg tccacgatga taaatatcta gagggaatat aatatagtcc 40920 ataggatgcc aatctagcaa tgtcgaataa ctgtaatttt attcttcgct cttcattatg 40980 aattgattct tgaggtataa acctaacaca aattatatta ttagactttt cgtatgtaat 41040 gtctttcatg ttataagttt ttaatcctgg aatagaatct attttaatga ggcttttaaa 41100 cgcagagttc tccaacgagt caaagcataa tactctgttg gttttcttat atacgatgtt 41160 acgattttct tctttgaatg gaataggttt ttgaattagt ttataattac aacataatag 41220 ataaggaagt gtgcaaatag tacgcggaaa aaacataata gctcccctgt tttcatccat 41280 ggttttaagt aaatgatcac tggcttcttt agtcaatgga tattcgaaca ttaaccgttt 41340 catcatcatt ggacagaatc catatttctt aatgtaaaga gtgatcaaat cattgtgttt 41400 attgtaccat cttgttgtaa atgtgtattc ggttatcgga tctgctcctt tttctattaa 41460 agtatcgatg tcgatctcgt ctaagaattc aactatatcg acatatttca tttgtataca 41520 cataaccatt actaacgtag aatgtatagg aagagatgta acgggaacag ggtttgttga 41580 ttcgcaaact attctaatac ataattcttc tgttaatacg tcttgcacgt aatctatta t 41640 agatgccaag atatctatat aattattttg taagatgatg ttaactatgt gatctatata 41700 agtagtgtaa taattcatgt atttcgatat atgttccaac tctgtctttg tgatgtctag 41760 tttcgtaata tctatagcat cctcaaaaaa tatattcgca tatattccca agtcttcagt 41820 tctatcttct aaaaaatctt caacgtatgg aatataataa tctattttac ctcttctgat 41880 atcattaatg atatagtttt tgacactatc ttctgtcaat tgattcttat tcactatatc 41940 taagaaacgg atagcgtccc taggacgaac tactgccatt aatatctcta ttatagcttc 42000 tggacataat tcatctatta taccagaatt aatgggaact attccgtatc tatctaacat 42060 agttttaaga aagtcagaat ctaagacctg atgttcatat attggttcat acatgaaatg 42120 atctctattg atgatagtga ctatttcatt ctctgaaaat tggtaactca ttctatatat 42180 gctttccttg ttgatgaagg atagaatata ctcaatagaa tttgtaccaa caaactgttc 42240 tcttatgaat cgtatatcat catctgaaat aatcatgtaa ggcatacatt taacaattag 42300 agacttgtct cctgttatca atatactatt cttgtgataa tttatgtgtg aggcaaattt 42360 gtccacgttc tttaattttg ttatagtaga tatcaaatcc aatggagcta cagttcttgg 42420 cttaaacaga tatagttttt ctggaacgaa ttctacaaca ttattataaa g gactttggg 42480 tagataagtg ggatgaaatc ctattttaat taatgcgata gccttgtcct cgtgcagata 42540 tccaaacgct tttgtgatag tatggcattc attgtctaga aacgctctac gaatatctgt 42600 gacagatatc atctttagag aatatactag tcgcgttaat agtactacaa tttgtatttt 42660 ttaatctatc tcaataaaaa aattaatatg tatgattcaa tgtataacta aactactaac 42720 tgttattgat aactagaatc agaatctaat gatgacgtaa ccaagaagtt tatctactgc 42780 caatttagct gcattatttt tagcatctcg tttagatttt ccatctgcct tatcgaatac 42840 tcttccgtcg atatctacac aggcataaaa tgtaggagag ttactaggcc ccactgattc 42900 aatacgaaaa gaccaatctc tcttagttat ttggcagtac tcattaataa tggtgacagg 42960 gttagcatct ttccaatcaa taattttttt agccggaata acatcatcaa aagacttatg 43020 atcctctctc attgattttt cgcgggatac atcatctatt atggcgtcag ccataacatc 43080 agcatccggc ttatccgcct ccgttgtcat aaaccaacga ggaggaatat cgtcggagct 43140 gtacaccata gcactacgtt gaagatcgta cagagcttta ttaacttctc gcttctccat 43200 attaagttgt ctagttagtt gtgcagcagt agctccttcg attccaatgt ttttaatagc 43260 cgcacacaca atctctgcgt cagaacgctc gtcaatatag atct tagaca tttttagaga 43320 gaactaacac aaccagcaat aaaactaatt tattttatca tttttttatt catcatcctc 43380 tggtggttcg tcgtttctat cgaatgtgga tctgattaac ccgtcatcta taggtgatgc 43440 tggttctgga gattctggag gagatggatt attatctgga agaatctctg ttatttcctt 43500 gttttcatgt atcgattgcg ttgtaacatt aagattgcga aatgctctaa atttgggagg 43560 cttaaagtgt tgtttgcaat ctctacacgc atgtctaact agtggaggtt cgtcagcggc 43620 tctagtttga atcatcatcg gcgtagtatt cctactttta cagttaggac acggtgtatt 43680 gtatttctcg tcgagaacgt taaaataatc gttgtaactc acatccttta ttttatctat 43740 attgtattct actcctttct taatgcattt tataccgaat aagagatagc gaaggaattc 43800 tttttcggtg ccgctagtac ccttaatcat atcacatagt gttttatatt ccaaatttgt 43860 ggcaatagac ggtttatttc tatacgatag tttgtttctg gaatcctttg agtattctat 43920 accaatatta ttctttgatt cgaatttagt ttcttcgata ttagattttg tattacctat 43980 attcttgatg tagtactttg atgatttttc catggcccat tctattaagt cttccaagtt 44040 ggcatcatcc acatattgtg atagtaattc tcggatatca gtagcggcta ccgccattga 44100 tgtttgttca ttggatgagt aactactaat gtataca ttt tccatttata acacttatgt 44160 attaactttg ttcatttata ttttttcatt attatgttga tattaacaaa agtgaatata 44220 tatgttaata attgtattgt ggttatacgg ctacaatttc ataatgagtg gaagtcagtg 44280 tccgatgatc aatgacgata gctttactct gaaaagaaag tatcaaatcg atagtgcgga 44340 gtcaacaata aaaatggata agaagaggat aaagtttcag aatagagcca aaatggtaaa 44400 agaaataaat cagacaataa gagcagcaca aactcattac gagacattga aactaggata 44460 cataaaattt aagagaatga ttaggactac tactctagaa gatatagcac catctattcc 44520 aaataatcag aaaacttata aactattctc ggacatttca gccatcggca aagcatcaca 44580 gaatccgagt aagatggtat atgctctgct gctttacatg tttcccaatt tgtttggaga 44640 tgatcataga ttcattcgtt atagaatgca tccaatgagt aaaatcaaac acaagatctt 44700 ctctcctttc aaacttaatc ttattagaat attagtggaa gaaagattct ataataatga 44760 atgcagatct aataaatgga gaataattgg aacacaagtt gataaaatgt tgatagctga 44820 atctgataaa tatacaatag atgcaaggta taacctaaaa cccatgtata gaatcaaggg 44880 aaaatctgaa gaagataccc tctttatcaa acagatggta gaacaatgtg tgacatccca 44940 ggaattggtg gaaaaagtgt tgaagatact gtttagagat ttgttcaaga gtggagaata 45000 caaagcgtac agatacgatg atgatgtaga aaatggattt attggattgg atacactaaa 45060 attaaacatt gttcatgata tagttgaacc atgtatgcct gttcgtaggc cagtggctaa 45120 gatactgtgt aaagaaatgg taaataaata ctttgagaat ccgctacata ttattggtaa 45180 aaatcttcaa gagtgcattg actttgttag tgaataggca tttcatcttt ctccaatact 45240 aattcaaatt gttaaattaa taatggatag tataaatagt tattagtgat aaaatagtaa 45300 aaataattat tagaataaga gtgtagtatc atagataact ctcttctata aaaatggatt 45360 ttattcgtag aaagtatctt atatacacag tagaaaataa tatagatttt ttaaaggatg 45420 atacattaag taaagtaaac aattttaccc tcaatcatgt actagctctc aagtatctag 45480 ttagcaattt tcctcaacac gttattacta aggatgtatt agctaatacc aatttttttg 45540 ttttcataca tatggtacga tgttgtaaag tgtacgaagc ggttttacga cacgcatttg 45600 atgcacccac gttgtacgtt aaagcattga ctaagaatta tttatcgttt agtaacgcaa 45660 tacaatcgta caaggaaacc gtgcataaac taacacaaga tgaaaaattt ttagaggttg 45720 ccgaatacat ggacgaatta ggagaactta taggcgtaaa ttatgactta gttcttaatc 45780 cattatttca cggaggggaa cc catcaaag atatggaaat cattttttta aaactgttta 45840 agaaaacaga cttcaaagtt gttaaaaaat taagtgttat aagattactt atttgggctt 45900 acctaagcaa gaaagataca ggcatagagt ttgcggataa tgatagacaa gatatataca 45960 ctctatttca acaaactggt agaatagtcc atagcaatct aacagaaacg tttagagatt 46020 atatctttcc cggagataag actagctatt gggtgtggtt aaacgaaagt atagctaatg 46080 atgcggatat tgttcttaat agacacgcca ttaccatgta tgataaaatt cttagttata 46140 tatactctga gataaaacaa ggacgcgtta ataaaaacat gcttaagtta gtttatatct 46200 ttgagcctga aaaagatatc agagaacttc tgctagaaat catatatgat attcctggag 46260 atatcctatc tattattgat gcaaaaaacg acgattggaa aaaatatttt attagttttt 46320 ataaagctaa ttttattaac ggtaatacat ttattagtga tagaacgttt aacgaggact 46380 tattcagagt tgttgttcaa atagatcccg aatatttcga taatgaacga attatgtctt 46440 tattctctac gagtgctgcg gacattaaac gatttgatga gttagatatt aataacagtt 46500 atatatctaa tataatttat gaggtgaacg atatcacatt agatacaatg gatgatatga 46560 agaagtgtca aatctttaac gaggatacgt cgtattatgt taaggaatac aatacatacc 46620 tgtttttgca cgagt cggat cccatggtca tagagaacgg aatactaaag aaactgtcat 46680 ctataaaatc caagagtaga cggctgaact tgtttagcaa aaacatttta aaatattatt 46740 tagacggaca attggctcgt ctaggtcttg tgttagatga ttataaagga gacttgttag 46800 ttaaaatgat aaaccatctt aagtctgtgg aggatgtatc cgcattcgtt cgattttcta 46860 cagataaaaa ccctagtatt cttccatcgc taatcaaaac tattttagct agttataata 46920 tttccatcat cgtcttattt caaaggtttt tgagagataa tctatatcat gtagaagaat 46980 tcttggataa aagcatccat ctaaccaaga cggataagaa atatatactt caattgataa 47040 gacacggtag atcatagaac agaccaaata tattattaat aatttgtata tacatagata 47100 taattatcac acatttttga taaatgggaa ctgctgcaac aattcagact cccaccaaat 47160 taatgaataa agaaaatgca gaaatgattt tggaaaaaat tgttgatcat atagttatgt 47220 atattagtga cgaatcaagt gattcagaaa ataatcctga atatattgat tttcgtaaca 47280 gatacgaaga ctatagatct ctcattataa aaagtgatca cgagtttgta aagctatgta 47340 aaaatcatgc agagaaaagt tctccagaaa cgcaacaaat gattatcaaa cacatatacg 47400 aacaatatct tattccagta tctgaagtac tattaaaacc tataatgtcc atgggtgaca 47460 taattaca ta taacggatgt aaagacaatg aatggatgct agaacaactc tctaccctaa 47520 actttaacaa tctccgcaca tggaactcat gtagcatagg caatgtaacg cgtctgtttt 47580 atacattttt tagttatctg atgaaagata aactaaatat ataagtataa tcccattcta 47640 atactttaac ctgatgtatt acctgcatct tattagaata ttaacctaac taaaagacat 47700 aacatagttg ataaaaagcg gtaggatata aatattatgg ctgccaccgt tccgcgtttt 47760 gacgacgtgt acaaaaatgc acaaagaaga attctagatc aagaaacatt ttttagtaga 47820 ggtctaagta gaccgttaat gaaaaacaca tatctatttg ataattacgc gtatggatgg 47880 ataccagaaa ctgcaatttg gagtagtaga tacgcaaact tagatgcaag tgactattat 47940 cccatttcgt tgggattact taaaaagttc gagtttctca tgtctctata taaaggtcct 48000 attcccgtat atgaagaaaa agtaaatact gaattcattg ctaatggatc gttctctggt 48060 agatacgtat catatcttcg aaagttttct gcccttccaa caaacgagtt tattagtttt 48120 ttgttactga cttccattcc aatctataat atcttgttct ggtttaaaaa tactcagttt 48180 gatattacta aacacacatt attcagatac gtctatacag ataatgccaa acacctggcg 48240 ttggctaggt atatgcatca aacaggagac tataagcctt tgtttagtcg tctcaaagag 48300 aattatatat ttaccggtcc cgttccaata agtatcaaag atatagatca ccctaatctt 48360 agtagagcaa gaagtccatc cgattatgag acattagcta atattagtac tatattgtac 48420 tttaccaagt atgatccggt attaatgttt ttattgtttt acgtacctgg gtattcaatt 48480 actacaaaaa ttactccagc cgtagaatat ctaatggata aactgaatct aacaaagagc 48540 gacgtacaac tgttgtaaat tattttatgc ttcgtaaaat gtaggttttg aaccaaacat 48600 tctttcaaag aatgagatgc ataaaacttt attatccaat agattgacta tttcggacgt 48660 caatcgttta aagtaaactt cgtaaaatat tctttgatca ctgccgagtt taaaacttct 48720 atcgataatt gtttcatatg ttttaatatt tacaagtttt ttggtccatg gtacattagc 48780 cggacaaata tatgcaaaat aatatcgttc tccaagttct atagtttctg gattattttt 48840 attatattca gtaaccaaat acatattagg gttatctgcg gatttataat ttgagtgatg 48900 cattcgactc aacataaata attctagagg agacgatcta ctatcaaatt cggatcgtaa 48960 atctgtttct aaagaacgga gaatatctat acatacctga ttagaattca tccgtccttc 49020 agacaacatc tcagacagtc tggtcttgta tgtcttaatc atattcttat gaaacttgga 49080 aacatctctt ctagtttcac tagtaccttt attaattctc tcaggtacag attttgaat t 49140 cgacgatgct gagtatttca tcgttgtata tttcttcttc gattgcataa tcagattctt 49200 atataccgcc tcaaactcta ttttaaaatt attaaacaat actctattat taatcagtcg 49260 ttctaactct ttcgctattt ctatagactt atcgacatct tgactgtcta tctctgtaaa 49320 cacggagtcg gtatctccat acacgctacg aaaacgaaat ctgtaatcta taggcaacga 49380 tgttttcaca atcggattaa tatctctatc gtccatataa aatggattac ttaatggatt 49440 ggcaaaccgt aacataccgt tagataactc tgctccattt agtaccgatt ctagatacaa 49500 gatcattcta cgtcctatgg atgtgcaact cttagccgaa gcgtatgagt atagagcact 49560 atttctaaat cccatcagac catatactga gttggctact atcttgtacg tatattgcat 49620 ggaatcatag atggcctttt cagttgaact ggtagcctgt tttagcatct ttttatatct 49680 ggctctctct gccaaaaatg ttcttaatag tctaggaatg gttccttcta tcgatctatc 49740 gaaaattgct atttcagaga tgaggttcgg tagtctaggt tcacaatgaa ccgtaatata 49800 tctaggaggt ggatatttct gaagcaagag ctgattattt atttcttctt ccaatctatt 49860 ggtactaaca acgacaccga ctaatgtttc cggagataga tttccaaaga tacacacatt 49920 aggatacaga ctgttataat caaagattaa tacattatta ctaaacattt t ttgttttgg 49980 agcaaatacc ttaccgcctt cataaggaaa cttttgtttt gtttctgatc taactaagat 50040 agttttagtt tccaacaata gctttaacag tggacccttg atgactgtac tcgctctata 50100 ttcgaatacc atggattgag gaagcacata tgttgacgca cccgcgtctg tttttgtttc 50160 tactccataa tactcccaca aatactgaca caaacaagca tcatgaatac agtatctagc 50220 catatctaaa gctatgttta gattataatc cttatacatc tgagctaaat caacgtcatc 50280 ctttccgaaa gataatttat atgtatcatt aggtaaagta ggacatgata gtacgacttt 50340 aaatccattt tcccaaatat ctttacgaat tactttacat ataatatcct catcaacagt 50400 cacataatta cctgtggtta aaacctttgc aaatgcagcg gctttgcctt tcgcgtccgt 50460 agtatcgtca ccgatgaacg tcatttctct aactcctcta tttaatactt tacccatgca 50520 actgaacgcg ttcttggata tagaatccaa tttgtacgaa tccaattttt cagatttttg 50580 aatgaatgaa tatagatcga aaaatatagt tccattattg ttattaacgt gaaacgtagt 50640 attggccatg ccgcctactc ccttatgact agactgattt ctctcataaa tacagagatg 50700 tacagcttcc tttttgtccg gagatctaaa gataatcttc tctcctgtta ataactctag 50760 acgattagta atatatctca gatcaaagtt atgtccgtta aagg taacga cgtagtcgaa 50820 cgttagttcc aacaattgtt tagctattcg taacaaaact atttcagaac atagaactag 50880 ttctcgttcg taatccattt ccattagtga ctgtatcctc aaacatcctc tatcgacggc 50940 ttcttgtatt tcctgttccg ttaacatctc ttcattaatg agcgtaaaca ataatcgttt 51000 accacttaaa tcgatataac agtaacttgt atgcgagatt gggttaataa atacagaagg 51060 aaacttctta tcgaagtgac actctatatc tagaaataag tacgatcttg ggatatcgaa 51120 tctaggtatt tttttagcga aacagttacg tggatcgtca caatgataac atccattgtt 51180 aatctttgtc aaatattgct cgtccaacga gtaacatccg tctggagata tcccgttaga 51240 aatataaaac caactaatat tgagaaattc atccatggtg gcattttgta tgctgcgttt 51300 ctttggctct tctatcaacc acatatctgc gacggagcat tttctatctt taatatctag 51360 attataactt attgtctcgt caatgtctat agttctcatc tttcccaacg gcctcgcatt 51420 aaatggagga ggagacaatg actgatatat ttcgtccgta actacgtaat aaaagtaatg 51480 aggaaatcgt ataaatacgg tctcgccatt tcgacatctg gatttcagat ataaaaatct 51540 gttttcaccg tgactttcaa accaattaat gcaccgaaca tccatttata gaatttagaa 51600 atatattttc atttaaatga atcccaaaca ttgggga aga gccgtatgga ccattatttt 51660 tatagtactt tcgcaagcgg gtttagacgg caacatagaa gcgtgtaaac gaaaactata 51720 tactatagtc agcactcttc catgtcctgc atgtagacgg cacgcgacta tcgctataga 51780 ggacaataat gtcatgtcta gcgatgatct gaattatatt tattattttt tcatcagatt 51840 atttaacaat ttggcatctg atcccaaata cgcgatcgat gtgacaaagg ttaacccttt 51900 ataaacttaa cccattataa aacttatgat tagtcacgac tgaaataacc gcgtgattat 51960 tttttggtat aattctacac ggcatggttt ctgtaactat gaattcaacc cccgttacat 52020 tagtgaaatc tttaacaaac agcaagggtt cgtcaaagac ataaaactca ttgtttacaa 52080 tcgaaataga ccccctatca cacttaaaat aaaaaatatc cttatccttt accaccaaat 52140 aaaattctga ttggtcaatg tgaatgtatt cacttaacag ttccacaaat ttatttatta 52200 actccgaggc acatacatcg tcggtatttt ttatggcaaa ctttactctt ccagcatccg 52260 tttctaaaaa aatattaacg agttccattt atatcatcca atattattga aatgacgttg 52320 atggacagat gatacaaata agaaggtacg gtacctttgt ccaccatctc ctccaattca 52380 tgctctattt tgtcattaac tttaatgtat gaaaacagta cgccacatgc ttccatgaca 52440 gtgtgtaaca ctttggatac aaaatgtttg acattagtat aattgtccaa gactgtcaat 52500 ctataataga tagtagctat aatatattct atgatggtat tgaagaagat gacaatcttg 52560 gcatattgat catttaacac agacatggta tcaacagata gcttgaatga aagagaatca 52620 gtaattggaa taagcgtctt ctcgatagag tgtccgtata ccaacatgtc tgatattttg 52680 atgtattcca ttaaattatt tagttttttc tttttattct cgttaaacag catttctgtc 52740 aacggacccc aacatcgttg accgattaag ttttgattga tttttccgtg taaggcgtat 52800 ctagtcagat cgtatagcct atccaataat ccatcatctg tgcgtagatc acatcgtaca 52860 ctttttaatt ctctatagaa gagcgacaga cagcaatttc tttattctct acagatgtaa 52920 gatacttgaa gacattccta tgatgatgca gaattttgga taacacggta ttgatggtat 52980 ctgttaccat aattcctttg atggctgata gtgtcagagc acaagatttc caatctttgt 53040 tttgatatct atatcagaca gcatggtgcg tctgacaaca caaggattaa gacggaaaga 53100 tgaaatgatt ctctcaacat cttcaatgga taccttgcta ttttttctgg cattatctat 53160 atgtgcgaga atatcctcta gagaatcagt atcctttttg atgatagtgg atctcaatga 53220 catgggacgt ctaaaccttc ttattctatc accagattgc atggtgattt gtcttctttc 53280 ttttatcata atgtaatctc ta aattcatc ggcaaattgt ctatatctaa aatcataata 53340 tgagatgttt acctctacaa atatctgttc gtccaatgtt agagtatcta catcagtttt 53400 gtattccaaa ttaaacatgg caacggattt aattttatat tcctctatta agtcctcgtc 53460 gataataaca gaatgtagat aatcatttaa tccatcgtac atggttggaa gatgcttgtt 53520 gacaaaatct ttaattgtct tgatgaaggt gggactatat ctaacatctt gattaataaa 53580 atttataaca ttgtccatag gatactttgt aactagtttt atacacatct cttcatcggt 53640 aagtttagac agaatatcgt gaacaggtgg tatattatat tcatcagata tacgaagaac 53700 aatgtccaaa tctatattgt ttaatatatt atatagatgt agcgtagctc ctacaggaat 53760 atctttaact aagtcaatga tttcatcaac cgttagatct attttaaagt taatcatata 53820 ggcattgatt tttaaaaggt atgtagcctt gactacattc tcattaatta accattccaa 53880 gtcactgtgt gtaagaagat tatattctat cataagcttg actacatttg gtcccgatac 53940 cattaaagaa ttcttatgat ataaggaaac agattttagg tactcatcta ctctacaaga 54000 attttggaga gccttaacga tatcagtgac gtttattatt tcaggaggaa agaatctaac 54060 attgagaata tcggaattaa tagcttccag atacagtgat tttggcaata gtccgtgtaa 54120 tccataatcc agtaa cacga gctggtgctt gctagacacc ttttcaatgt ttaatttttt 54180 tgaaataagc tttgataaag ccttcctcgc aaattccgga tacatgaaca tgtcggcgac 54240 atgattaagt attgtttttt cattattttc tcaacaagtt ctcaataccc caatagatga 54300 tagaatatca cccaatgcgt ccatgttgtc tatttccaac aggtcgctat atccaccaat 54360 agaagttttt ccaaaaaaga ttctaggaac agttctacca ccagtaattt gttcaaaata 54420 gtcacgcaat tcattttcgg gtttaaattc tttaatatcg acaatttcat acgctcctct 54480 tttgaaacta aacttattta gaatatccag tgcatttcta caaaaaggac atgtatactt 54540 gacaaaaatt gtcactttgt tattggccaa cctttgttgt acaaattcct cggccatttt 54600 aatatttaag tgatataaaa ctatctcgac ttatttaact ctttagtcga gatatatgga 54660 cgcagatagc tatatgatag ccaactacag aaggcaaacg ctataaaaaa cataattacg 54720 acgagcatat ttataaatat ttttattcag cattacttga tatagtaata ttaggcacag 54780 tcaaacattc aaccactctc gatacattaa ctctctcatt ttctttaaca aattctacaa 54840 tatcttcgta aaaagattct tgaaactttt tagaatatct atcgactcta gatgaaatag 54900 cgttcgtcaa catactatgt tttgtataca taaaggcgcc cattttaaca gtttctagtg 54960 acaaaatgct agcgatccta ggatccttta gaatcacata gattgacgat tcgtctctct 55020 tagtaactct agtaaaataa tcatacaatc tagtacgcga aataatatta tccttgactt 55080 gaggagatct aaacaatcta gttttgagaa catcgataag ttcatcggga atgacataca 55140 tactatcttt aatagaactc ttttcatcca gttgaatgga ttcgtcctta accaactga t 55200 taatgagatc ttctatttta tcattttcca gatgatatgt atgtccatta aagttaaatt 55260 gtgtagcgct tctttttagt ctagcagcca atactttaac atcactaata tcgatataca 55320 aaggagatga tttatctatg gtattaagaa ttcgtttttc gacatctgtc aaaaccaatt 55380 cctttttgcc tgtatcatcc agttttccat cctttgtaaa gaaattattt tctactagac 55440 tattaataag actgataagg attcctccat aattgcacaa tccaaacttt ttaacaaaac 55500 tagactttac aagatctaca ggaatgcgta attcaggttt cttagcttgt gattttttct 55560 tttgtggaca ttttcttgtg accaactcat ctaccatttc attgatttta gcagtgaaat 55620 aagctttcaa tgcacgggca ctgatactat tgaaaacgag ttgatcttca aattccgcca 55680 tttaagttca ccaaacaact tttaaataca aatatatcaa tagtagtaga ataagaacta 55740 taaaaaaaat aataattaac caataccaac cccaacaacc ggtattatta gttgatgtga 55800 ctgttttctc atcacttaga acagatttaa caatttctat aaagtctgtc aaatcatctt 55860 ccggagaccc cataaataca ccaaatatag cggcgtacaa cttatccatt tatacattga 55920 atattggctt ttctttatcg ctatcttcat catattcatc atcaatatca acaagtccca 55980 gattacgagc cagatcttct tctacatttt cagtcattga tacacgttca c tatctccag 56040 agagtccgat aacgttagcc accacttctc tatcaatgat tagtttcttg agtgcgaatg 56100 taatttttgt ttccgttccg gatctataga agacgatagg tgtgataatt gccttggcca 56160 attgtctttc tcttttactg agtgattcta gttcaccttc tatagatctg agaatggatg 56220 attctccagt cgaaacatat tctaccatgg atccgtttaa tttgttgatg aagatggatt 56280 catccttaaa tgttttctct gtaatagttt ccaccgaaag actatgcaaa gaatttggaa 56340 tgcgttcctt gtgcttaatg tttccataga cggcttctag aagttgatac aacataggac 56400 tagccgcggt aacttttatt tttagaaagt atccatcgct tctatcttgt ttagatttat 56460 ttttataaag tttagtctct ccttccaaca taataaaagt ggaagtcatt tgactagata 56520 aactatcagt aagttttata gagatagacg aacaattagc gtattgagaa gcatttagtg 56580 taacgtattc gatacatttt gcattagatt tactaatcga ttttgcatac tctataacac 56640 ccgcacaagt ctgtagagaa tcgctagatg cagtaggtct tggtgaagtt tcaactctct 56700 tcttgattac cttactcatg attaaaccta aataattgta ctttgtaata taatgatata 56760 tattttcact ttatctcatt tgagaataaa aatgtttttg tttaaccact gcatgatgta 56820 cagatttcgg aatcgcaaac caccagtggt tttattttat cctt gtccaa tgtgaattga 56880 atgggagcgg atgcgggttt cgtacgtaga tagtacattc ccgtttttag accgagactc 56940 catccgtaaa aatgcatact cgttagtttg gaataactcg gatctgctat atggatattc 57000 atagattgac tttgatcgat gaaggctccc ctgtctgcag ccatttttat gatcgtcttt 57060 tgtggaattt cccaaatagt tttataaact cgcttaatat cttctggaag gtttgtattc 57120 tgaatggatc caccatctgc cataatccta ttcttgatct catcattcca taattttctc 57180 tcggttaaaa ctctaaggag atgcggatta actacttgaa attctccaga caatactctc 57240 cgagtgtaaa tattactggt atacggttcc accgactcat tatttcccaa aatttgagca 57300 gttgatgcag tcggcatagg tgccaccaat aaactatttc taagaccgta tgttctgatt 57360 ttatctttta gaggttccca attccaaaga tccgacggta caacattcca aagatcatat 57420 tgtagaatac cgttactggc gtacgatcct acatatgtat cgtatggtcc ttccttctca 57480 gctagttcac aactcgcctc taatgcaccg taataaatgg tttcgaagat cttcttattt 57540 agatcttgtg cttccaggct atcaaatgga taatttaaga gaataaacgc gtccgctaat 57600 ccttgaacac caataccgat aggtctatgt ctcttattag agatttcagc ttctggaata 57660 ggataataat taatatctat aattttattg agatttc tga caattacttt gaccacatcc 57720 ttcagtttga gaaaatcaaa tcgcccatct attacaaaca tgttcaaggc aacagatgcc 57780 agattacaaa cggctacctc attagcatcc gcatattgta ttatctcagt gcaaagatta 57840 ctacacttga tagttcctaa attttgttga ttactctttt tgttacacgc atccttataa 57900 agaatgaatg gagtaccagt ttcaatctga gattctataa tcgctttcca gacgactcga 57960 gcctttatta tagatttgta tctcctttct ctttcgtata gtgtatacaa tcgttcgaac 58020 tcgtctcccc aaacattgtc caatccagga cattcatccg gacacatcaa cgaccactct 58080 ccgtcatcct tcactcgttt cataaagaga tcaggaatcc aaagagctat aaatagatct 58140 ctggttctat gttcctcgtt tcctgtattc tttttaagat cgaggaacgc cataatatca 58200 gaatgccacg gttccaagta tatggccata actccaggcc gtttgtttcc tccctgatct 58260 atgtatctag cggtgttatt ataaactctc aacattggaa taataccgtt tgatatacca 58320 ttggtaccgg agatatagct tccactggca cgaatattac taattgatag acctattccc 58380 cctgccattt tagagattaa tgcgcatcgt tttaacgtgt catagatacc ctctatgcta 58440 tcatcgatca tgttaagtag aaaacagcta gacatttggt gacgactagt tcccgcatta 58500 aataaggtag gagaagcgtg cgtaaaccat ttttcagaaa gtagattgta cgtctcaata 58560 gctgagtcta tatcccattg atgaattcct actgcgacac gcattaacat gtgctgaggt 58620 ctttcaacga tcttgttgtt tattttcaac aagtaggatt tttccaaagt tttaaaacca 58680 aaatagttgt atgaaaagtc tcgttcgtaa ataataaccg agttgagttt atccttatat 58740 ttgttaacta tatccatggt gatacttgaa ataatcggag aatgtttccc atttttagga 58800 ttaacatagt tgaataaatc ctccatcact tcactaaata gtttttttgt ttccttgtgt 58860 agatttgata cggctattct ggcggctaga atggcataat ccggatgttg tgtagtacaa 58920 gtggctgcta tttcggctgc cagagtgtcc aattctaccg ttgttactcc attatatatt 58980 ccttgaataa ccttcatagc tattttaata ggatctatat gatccgtgtt taagccataa 59040 cataattttc taatacgaga cgtgatttta tcaaacatga cattttcctt gtatccattt 59100 cgtttaatga caaacatttt tgttggtgta ataaaaaaaa ttatttaact tttcattaat 59160 agggatttga cgtatgtagc gtacaaaatt atcgttcctg gtatatagat aaagagtcct 59220 atatatttga aaatcgttac ggctcgatta aactttaatg attgcatagt gaatatatca 59280 ttaggattta actccttgac tatcatggcg gcgccagaaa ttaccatcaa aagcattaat 59340 acagttatgc cgatcgcagt ta gaacggtt atagcatcca ccatttatat ctaaaaatta 59400 gatcaaagaa tatgtgacaa agtcctagtt gtatactgag aattgacgaa acaatgtttc 59460 ttacatattt tttttttatt agtaaccgac ttaatagtag gaactggaaa actagacttg 59520 attattctat aagtatagat acccttccaa ataatattct ctttgataaa agttccagaa 59580 aatgtagaat tttttaaaaa gttatctttt gctattacca agattgtgtt tagacgctta 59640 ttattaatat gagtgatgaa atccacaccg cctctagata tcgcttttat ttccacatta 59700 gatggtaaat ccaatagtga aactatcttt ttaggaatgt atggactcgc gtttagagga 59760 gtgaacgtct taggcgtcgg aaaggggccg gccttttttt ctagacacta aataaatagt 59820 aagattaaat taattataaa attatgtata taatattaat tataaaatta tgtatatgat 59880 tactaactt tagttagata aattataataat acataaattta 60 attatatatta atattataaa 59940 cctatta atattataaaa 59940 ttaatagtata atatata <210> 12 <211> 60021 <212> DNA <213> Artificial Sequence <220> <223> sMVA fragment F1 <400> 12 ggcctagcag gccggccttt ttttctagac actaaataaa tagtaagatt aaattaatta 60 taaaattatg tatataatat taattataaa attatgtata tgatttacta actttagtta 120 gataaattaa taatacataa attttagtat attaatatta taaattaata atacataaat 180 tttagtatat taatattata ttttaaatat ttatttagtg tctagaaaaa aatgtgtgac 240 caacgaccgt aggaaactct agagggtaag aaaaatcaat cgctttatag agaccatcag 300 aaagaggttt aatatttttg tgagaccatc gaaggagaaa gagataaaac ttttttacga 360 ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac 420 ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa 480 gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg 540 aaggagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 600 agaccatcga aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat 660 atttttgtga gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag 720 aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 780 catcagaaag aggtttaata tttttgtgag accatcgaag gagaaagaga taaaactttt 840 ttacgactcc a tcagaaaga ggtttaatat ttttgtgaga ccatcgaaga gagaaagaga 900 ataaaaatat tttagtgaca ccatcagaaa gaggtttaat atttttgtga gaccatcgaa 960 gagagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 1020 gaccatcgaa ggagaaagag ataaaacttt tttacgactc catcagaaag aggtttaata 1080 tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc catcagaaag 1140 aggtttaata tttttgtgag accatcgaag agagaaagag ataaaacttt tttacgactc 1200 catcagaaag accatcgaag agagaaagag aaagagatag ttagtctaga tatttttctt 1260 agtacaaaag tcaatgtttt aaaatatatg gacaagaatt tgtctgtata aaaacttgtg 1320 tgaaattttg taccaaagaa aaaatgtgag cagtatcccc tacatggatt ttactagatc 1380 atttatatac caaaaaatat tatacgatct acgttttatt atatgatttt aacgtgtaaa 1440 ttataaacat tattttatga tatacaattg tctggtaacc tagatgggca taggggatga 1500 gtatatgttg ttggacgtta ttgtttaaga aatagttgat gcatcagaaa gaggtttaat 1560 atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttacgact ccatcagaaa 1620 gaggtttaat atttttgtga gaccatcgaa gagagaaaga gataaaactt ttttatgact 1680 ccattgaaga gagaatgag a ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1740 attttttatg agaccatcaa agagagaaag agaataaaaa tattttatga ctccattgaa 1800 gagagaaaga gaaaatgaga ataaaaatat tttagtgaca ccatcagaaa gaggtttaat 1860 attttttatg agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt 1920 tatgagacca tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag 1980 accatcaaag agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc 2040 aaagagagaa agagaataaa aatatttttg taaaactttt tttatgagac catcaaagag 2100 agaaagagaa taaaaatatt tttgtaaaac tttttttatg agaccatcaa agagagaaag 2160 agaataaaaa tatttttgta aaactttttt tatgagacca tcaaagagag aaagagaata 2220 aaaatatttt tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata 2280 ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca ccatcagaaa 2340 gaggtttaat atttttgtga gaccatcgaa gagagaaaga gaataaaaat attttatgac 2400 tccattgaag agagaaagag aataaaaata ttttagtgac accatcagaa agaggtttaa 2460 tattttttat gagaccatca aagagagaaa gagaataaaa atatttttgt aaaacttttt 2520 ttatgagacc atcaaagaga gaaa gagaat aaaaatattt ttgtaaaact ttttttatga 2580 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 2640 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 2700 gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 2760 gagaataaaa atattttatg actccattga agagagaatg agaataaaaa tattttagtg 2820 acaccatcag aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa 2880 aatattttat gactccattg aagagagaaa gagaataaaa atattttagt gacaccatca 2940 gaaagaggtt taatattttt tatgagacca tcaaagagag aaagagaata aaaatatttt 3000 tgtaaaactt tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 3060 acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 3120 tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 3180 agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 3240 tcaaagagag aaagagaata aaaatatttt tgtaaaactt tttttatgag accatcaaag 3300 agagaaagag aataaaaata tttttgtaaa acttttttta tgagaccatc aaagagagaa 3360 agagaataaa aatattttat gactccattg aagagagaat gagaataaaa atattttagt 3420 gacaccatca gaaagaggtt taatattttt gtgagaccat cgaagagaga aagagaataa 3480 aaatatttta tgactccatt gaagagagaa tgagaataaa aatattttag tgacaccatc 3540 agaaagaggt ttaatatttt ttatgagacc atcaaagaga gaaagagaat aaaaatattt 3600 ttgtaaaact ttttttatga gaccatcaaa gagagaaaga gaataaaaat atttttgtaa 3660 aaattataaa cattatttta tgatatacaa ttgtctggta acctagatgg gcatagggga 3720 tgttgataag ctcgacgagt atatgttgtt ggacgttatt gtttaagaaa tagttgatgc 3780 atcagaaaga gaataaaaaa tattttagtg agaccatcga agagagaaag agataaaact 3840 tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 3900 agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 3960 aggagaaaga gataaaactt ttttacgact ccatcagaaa gaggtttaat atttttgtga 4020 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 4080 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 4140 gagaaagaga ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa 4200 gagaataaaa atatttttgt aaaacttttt ttatg agacc atcaaagaga gaaagagaat 4260 aaaaatattt tatgactcca ttgaagagag aatgagaata aaaatatttt agtgacacca 4320 tcagaaagag gtttaatatt tttgtgagac catcgaagag agaaagagaa taaaaatatt 4380 ttatgactcc attgaagaga gaatgagaat aaaaatattt tagtgacacc atcagaaaga 4440 ggtttaatat tttttatgag accatcaaag agagaaagag aataaaaata tttttgtaaa 4500 acttttttta tgagaccatc aaagagagaa agagaataaa aatatttttg taaaactttt 4560 tttatgagac catcaaagag agaaagagaa taaaaatatt tttgtaaaac tttttttatg 4620 agaccatcaa agagagaaag agaataaaaa tatttttgta aaactttttt tatgagacca 4680 tcaaagagag aaagagaata aaaatatttt atgactccat tgaagagaga atgagaataa 4740 aaatatttta gtgacaccat cagaaagagg tttaatattt ttgtgagacc atcgaagaga 4800 gaaagagaat aaaaatattt tatgactcca ttgaagagag aaagagaata aaaatatttt 4860 agtgacacca tcagaaagag gtttaatatt ttttatgaga ccatcaaaga gagaaagaga 4920 ataaaaatat ttttgtaaaa ctttttttat gagaccatca aagagagaaa gagaataaaa 4980 atattttatg actccattga agagagaatg agaataaaaa tattttagtg acaccatcag 5040 aaagaggttt aatatttttg tgagaccatc gaagagagaa agagaataaa aatattttat 5100 gactccattg aagagagaat gagaataaaa atattttagt gacaccatca gaaagaggtt 5160 taatattttt gtgagaccat cgaagagaga aagagaataa aaatatttta tgactccatt 5220 gaagagagaa tgagaataaa aatattttag tgacaccatc agaaagaggt ttaatatttt 5280 ttatgagacc atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga 5340 gaccatcaaa gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat 5400 caaagagaga aagagaataa aaatattttt gtaaaacttt ttttatgaga ccatcaaaga 5460 gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat 5520 ttttgtgaga ccatcaaaga gagaaagaga ataaaaatat ttttgtgaga ccatcaaaga 5580 gagaaagaga ataaaaatat tttatgactc cattgaagag agaaagagaa taaaaatatt 5640 ttagtgacac catcagaaag aggtttaata tttttgtgag accatcgaag agagaaagag 5700 aataaaaata ttttatgact ccattgaaga gagaaagaga ataaaaatat tttagtgaca 5760 ccatcagaaa gaggtttaat attttttatg agaccatcaa agagagaaag agaataaaaa 5820 tattttttat gagaccatca aagagagaaa gagaataaaa atattttatg agaccatcaa 5880 agagagaaag agaataaaaa tattttttat gagaccatca aagaga gaaa gagaataaaa 5940 atattttatg agaccatcaa agagagaaag agaataaaaa tattttttat gagaccatca 6000 aagagagaaa gagaataaaa atatttttgt atgagaccat cagaaagagg tttaatattt 6060 ttgtgatacc ctgaaaggaa ataggaatag tgtcataatc gtatcacact attgagacag 6120 aaaaagaaga agtcgcgaga ggtaactttt tgttttgcaa accggaatat agtgtccggt 6180 acactttttt aattcgtggt gtgcctgaat cgttcgatta accctactca tccaatttca 6240 gatgaataga gttatcgatt cagacacacg ctttgagttt tgttgaatcg atgagtgaag 6300 tatcatcggt tgcaccttca gatgccgatc cgtcgacata cttgacctca agttcagatg 6360 attccttgca catgtctccg atacgaacgc taaactctag attcttgaca cattttgtat 6420 cgacgatcgt tgaaccgatg atatcttcgt aactcacttt cttatgagag atgttagacc 6480 cgagtactgg atgggtcttg atgtcgctgt ctttctcttc ttcgctacat ctgatgtcga 6540 tagacacctc acagtctttc catcagcgga ttctgagatg gatttaatct gaggacattt 6600 ggtgaatcca aagttcattc tcagacctcc accgatgatg gagtaataag tggtaggagg 6660 atctacatcc tcgactgatt ccacctcggg atctggatct gactcggact ctgtaatttc 6720 cgttacggat tggcaaatct tatcatcggt cggtgtttgg tcttgctttg t gactttgat 6780 aataacatcg attcccatat gatgtttgtt ttcttcttcc gtacacgatg aggatgattg 6840 ctgaagactg gcaggcacat gcatgccagt acgatatatt gtttcatgat tgctattgat 6900 tgagtactgt tctttatgat tctacttcct taccgtgcaa taaattagaa tatattttct 6960 acttttacga gaaattaatt attgtattta tgggtgaaaa acttactata aaaagcgggt 7020 gggtttggaa ttagtgatca gtttatgtat atcgcaacta ccgggcatat ggctacatta 7080 cccacatgat aagagattgt atcagtttcg tagtcttgag tattggtatt actatatagt 7140 atatagatgt cgacgctaga gttactgtct ccgaatgcgg catgatagta tcattctttg 7200 ctttcgttaa ctgtttggag gaagaatctt tgttattgca tttaatctcg aaattcagag 7260 tgcacacctt tctcctgtaa agaaacctga agtcgctacc ttattaagaa gacgggatcg 7320 cagtctttat gattcatagt aatagttagt tccgacgttg agatggattc gctgagaccg 7380 gtagtggtcg tccgagtaca cgatgtgtcg ttaactggat acaggttaat ttccacatcg 7440 atatagttaa aggtatttct gggtacgggt tcgcatttat ctgcggaaga gacggtgtga 7500 gaatatgttc cgagaccaca cggagaacag atgacgtctc cggatactcc gtatcctatt 7560 ccacattttg tttgggaaac acatgccttg catccatgat cgggagagca ttcacag att 7620 ctattgtgag tcgtgttaca cgatcgcgtc gacattgttg acagaaacgt gaccttcatt 7680 cttaccgtcg tccataaata cgttaggtat gtaccacata ctgtcgcgaa cgatgcgtcc 7740 atctcataat gatttacttt ttcataatta aagatgtgaa agaaaaccga acaatatatt 7800 tttttagtaa tgtttatgcg agacatataa aataaactcc gtgtttatga tgccggtaaa 7860 tgtttttatc atcttggacg gaatcgattt tgtaatatgc catggaaaca ggacattatc 7920 actccatgat aaattattta atggagtcga tcctctcatt gttctttgcg tatctcaatc 7980 tgtggcgttt gcttcgttta aataatatat caaacatgga gacgcctgat atgtaggcat 8040 tcttcattct attaatgtct gctctatagc gctttagttc cttatgacga ccggcgatat 8100 catacttact ttagaaggaa aatcatcatc taggattaag gcgtatctga tacaggcgaa 8160 taatggttca ggatatagat agcgtatatc tctattaaat gcgtcaatca tagtctctag 8220 agtgggatgg taactcagta ataaatcaac tagcttctct ttggtaactg cttttctgga 8280 tggccgtatt gattatcgag cgtgacactc gctccatatt ccaataaccg ctttgcaaat 8340 tgtatattat tgacatcgac cgcgtaatat agtagagtta tcgatcatat ctatatcatc 8400 catgtacttg cttagtatat caaatacatc ttcataacag tgatacccgc aattattaaa 84 60 tctcgataat atcagaccgt acatacatag acggccattg ttagatatgt gatttacagc 8520 cgcgtgtcca tattttccac gataaacctt acgacgttta catcgacgag attattatta 8580 acaaagttgt tgtccgtcgt cttatccaac atgcattgaa tgataggtat acttaccata 8640 tcgccgtaat gtaagtagtt tatcagtatg gcttgtacga tggattcatc ctgttgtcta 8700 aatctcttta gaatgttatc gatgatgtag tggttatatt ctctggaatc gtacgaagta 8760 atactacgca ttacgtcgac aagagtatga cgtctctcaa taagaagatt aacgatttcc 8820 atgtctacat tatatggggt tactctaaat cgcttgttta gataatacgc ctctaatata 8880 gggctgacgt cgtatactct acacgtgtcc acatccttta ttaataatct ctatatctat 8940 ggttgagcaa gaccagtagt attggatgga aacattgtta tcgatcaaac atttaattac 9000 atccttggat agagattctc tatgagacga tatatagtaa tgaagagagt tcttacacat 9060 atcactgttg tacatacagg tacgaaatac gtaaccggtg ctgtaacatt ctgatttaag 9120 aagccatagc aatacttctg gtctcggatt aggcgtcgtt acgtatatat ccaccaatcc 9180 gagaccattg attgcataat tcgtattctt ggacggacgt atccgtttat ccacaattag 9240 gtattttagc agacgtaagt cgaaatcatt tatattcgac ttgagttcgt tagaggaatt 9300 cga atagctg gatatcagta gatgcacaat ctgagatttt acgtatctat gcttactgta 9360 tgctcctagc ggagttaatc cttcgttgtt tctacaaagt ctctcgactc cgcgagagag 9420 taacagtcga acaatcttaa tgtctgtatc gcatttattg gagacgtaac aatgtagcgc 9480 attgtttcct cgtctatcta tatgttttga taagttgtga cacgtttcaa tttctagttt 9540 tatttttttg tacgtcacat cttcatccag tagacgacat agaatacatg tgcaatccat 9600 agctattctg gtgctaatta ttcctcataa gatgataaaa agtgtagtga gagagcatga 9660 aggagattta gtatttagca gtgcggatat gatccaagag ggtgagatag tcgttctcgt 9720 tcagaatctt tcgcagcata agtagtatgt cgatatactt atcgttgaag actcttccag 9780 agacgatagc tgattgagta caaagtccaa tgattgcacg aagttcttcg gcggttttca 9840 tggagtcatt tctgatgaaa catttaatga tctaaatttc agtttatgtt tgtaccccgt 9900 attcatactt aacaaattgg tattacatac cattaataat gcaagcataa aaaatcgtta 9960 gtagatgttt ctaaatatag gttccgtaag caaagaatat aagaatgaag cggtaatgat 10020 aaaatcaatc gttatctaaa atgatcatac tcatttattt tattctatta tattaacaca 10080 tacattttta acagcaacac attcaatatt gtattgttat ttttatatta tttacacaat 10140 taacaa tata ttattagttt atattactga attaataata taaaattccc aatcttgtca 10200 taaacacaca ctgagaaaca gcataaacac aaaatccatc aaaaatgttg ataaattatc 10260 tgatgttgtt gttcgctgct atgataatca gatcattcgc cgatagtggt aacgctatcg 10320 aaacgacatc gccagaaatt acaaacgcta caacagatat tccagctatc agattatgcg 10380 gtccagaggg agatggatat tgtttacacg gtgactgtat ccacgctaga gatatcgacg 10440 gtatgtattg tagatgctct catggttata caggcattag atgtcagcat gtagtattag 10500 tagactatca acgttcagaa aaaccaaaca ctacaacgtc atatatccca tctcccggta 10560 ttatgcttgt attagtaggc attattatta ttacgtgttg tctattatct gtttataggt 10620 tcactcgacg aactaaacta cctatacaag atatggttgt gccataattt ttataaattt 10680 tttttatgag tatttttaca aaaatgtata aagtgtatgt cttatgtata tttataaaaa 10740 tgctaaatat gcgatgtatc tatgttattt gtatttatct aaacaatacc tctacctcta 10800 gatattatac aaaaattttt tatttcggca tattaaagta aaatctagtt accttgaaaa 10860 tgaatacagt gggtggttcc gtatcaccag taagaacata atagtcgaat acagtatccg 10920 attgagattt tgcatacaat actagtctag aaagaaattt gtaatcatct tctgtgacgg 1098 0 gagtccatat atctgtatca tcgtcccatg ctatattcct gttatcatca ttagttaatg 11040 aaaataactc tcgtgcttca gaaaagtcaa atattgtatc catacataca tctccaaaac 11100 tatcgcttat acgtttatct ttaacgatac ctatacctag atggttattt actaacagac 11160 attttccaga tctattgact ataactccta tagtttccac atcaaccaag taatgatcat 11220 ctattgttat ataacaataa cataactctt ttccgttttt atcagtatgt atatctatat 11280 caacgtcgtc gttgtagtga atagtagtca ttgatctatt atatgaaacg gatatgtcta 11340 gaacggcaat tgttttacgt ccagttaaca ctttcgttga tttaaagtct agagtctttg 11400 caaacataat atccttatcc gactttatat ttcctgtagg gtggtataat tttattttgc 11460 ctccacatat cggtgtttcc aaatatatta ctagacaata ttccatatag ttattagtta 11520 agggtaccca attagaacac gtacgcttat tatcatcatt tggatcgtat ttcataaaag 11580 ttattgtact atcgatgtca acacattcta cattttttaa tcgtctatat agtatttttc 11640 tgatattttc tataatatca gaattgtctt ccatcggaag ttgtatacta tcggaatcag 11700 ttacatgttt aaataattct ctgatgtcat tccttataca atcaaattca ttattaaaca 11760 gtttaatagt ctgtagacct ttatcgtcgt aaatatccat tgtcttatta gttacgc tta 11820 tttttatgtg tttttacgtt gctttattat attttataag aatgattgtt tgacgaatca 11880 cgagaactat taagacacat tattaggtat atattataaa aaagtttttg attacgatgt 11940 tataagagga aagaggacac attaacatca tacatcaatt aactacattc ttataacatc 12000 gtaatcaaaa gaattgcaat tttgatgtat aacaactgtc aatgggttat ggaattgtat 12060 attacatatt atacggtatg ttggtaacga caaataccga tcggtaattg tctgccggtg 12120 taatagaatt atatatatct atctattaca ccggccttgt atacataata ataagttgtg 12180 gtagtatgat ctccatattt ataatttagg actttgtatt cagttttttt ggaatcataa 12240 aaaataaaaa aaagttttac taatttaaaa ttatttacat ttttttcact gtttagtcgc 12300 ggatatggaa ttcgatcctg ccaaaatcaa tacatcatct atagatcatg taacaatatt 12360 acaatacata gatgaaccaa atgatataag actaacagta tgcattatca caaaaataaa 12420 tccacatttg gctaatcaat ttcgggcttg gaaaaaacgt atcgccggaa gggactatat 12480 gactaactta tctagagata caggaataca acaatcaaaa cttactgaaa ctgtcaaaaa 12540 aatagaaaca tatatggtct atatatacac tacaatttag ttattaattg gataaccgat 12600 gtgattatca atcaatatta agaaggttgg taaattggta catagctaat aatacctata 12660 cacccaataa tacaacaacc atttctgagt tggatatcat caaaatactg gataaatacg 12720 aggacgtgta tagagtaagt aaagaaaaag aatgtgaaat ttgctatgaa gttgtttact 12780 caaaacgata gatactttgg tttattggat tcgtgtaatc atatattttg cataacatgc 12840 atcaatatat ggcatagaac acgaagagaa accggtgcgt cggataattg tcctatatgt 12900 cgtacccgtt ttagaaacat aacaatgagc aagttaacta ataaataaaa agtttaattt 12960 gttgacgacg tatgtcgtta ttttttctcg tataaaagat taatttgatt ctaatataat 13020 ctttagtatt ggataaatat caattcaaat taattccatt agattatatc ataaataaaa 13080 atagtagcac gcactacttc agccaaatat tcttttttga aacgccatct atcgtagtga 13140 ggacacaagt gaacctataa tgagcaaatt tattagtatc ggttacatga aggactttac 13200 gtagagtggt gattccacta tctgtggtac gaacggtttc atcttctttg atgccatcac 13260 ccagatgttc tataaacttg gtatcctttg ccaaccaata catatagcta aactcaggca 13320 tatgttccac acatcctgaa caatgaaatt ctccagaaga tgttacaatg tctagatttg 13380 gacatttggt ttcaaccgcg ttaacatatg agtgaacaca cccatacatg aaagcgatga 13440 gaaataggat tttcatcttg ccaaaatatc actagaaaaa at ttatttat caattttaaa 13500 ggtataaaaa atacttattg ttgctcgaat attttgtatt tgatggtata cggaagatta 13560 gaaatgtagg tattatcatc aactgattct atggttttat gtattctatc atgtttttt tattctatc atgtttttt tggattattatagt attatttt 13620 atttgc tactcacgta attctggatt attgacatat ctatgaataa ttttagctcc atgatcagta 13740 aatattaatg agaacatagt attaccacct accattattt ttttcatctc attcaattct 13800 taattgcaaa gatctatata atcattatag cgttgactta tggactctgg aatcttagac 13860 gatgtacagt catctataat catggcatat ttaatacatt gttttatagc atagtcgtta 13920 tctacgatgt tagatatttc tctcaatgaa tcaatcacac aatctaatgt aggtttatga 13980 cataatagca ttttcagcag ttcaatgttt ttagattcgt tgatggcaat ggctatacat 14040 gtatatccgt tatttgatct aatgttgaca tctgaaccgg attctagcag taaagatact 14100 agagattgtt tattatatct aacagccttg tgaagaagtg tttctcctcg tttgtcaatc 14160 atgttaatgt ctttaagata aggtaggcaa atgtttatag tactaagaat tgggcaagca 14220 taagacatgt cacaaagacc ctttttgtat gtataagtgt aaaaattata acattcatag 14280 ttggatttac ataggtgtcc aatcgggatc tctccatcat cgagataatt gatggcatct 14340 cccttccttt tttagtagat atttcatcgt gtaagaatca atattaatat ttctaaagta 14400 tccgtgtata gcctctttat ttaccacagt tccatattcc actagaggga tatcgccgaa 14460 tgtcatatac tcaattagta tatgttggag gacatccgag ttcattgttt tcaatatca a 14520 aaagatggtt tccttatcat ttctccatag tggtacaata ctacacatta ttccgtgcgg 14580 ctttccattt tccaaaaaca atttgaccaa atctacatct ttattgtatc tataatcact 14640 atttagataa tcagccataa ttactcgagt gcaacatgtt agatcgtcta tatatgaata 14700 agccgtgtta tctattcctt tcattaacaa tttaacgatg tctatatcta tatgagatga 14760 cttaatataa tattgaagag ctgtacaata gtttttatct ataaaagacg gcttgattcc 14820 gtgattaatt agacatttaa caacttccgg acgcacatat gctctcgtat ccgactctga 14880 atacagatga gagatgatat acagatgcaa tacggtaccg caatttcgta gttgataatc 14940 atcatacgcg tatcagtact cgtcctcata aagaacactg cagccatttt ctatgaacaa 15000 atcaataatt tcaggaacag gatcatctgt cattacataa ttttctataa ctgaacgatg 15060 gttttcacat ttaacactca agtcaaatcc atgttctacc aacaccttta tcaagtcaac 15120 gtctacattt ttggatttca tatagctgaa tatattaaag tcatttatgt tgctaaatcc 15180 agtggcttct agtagagcca tcgctatatc ctttaacttt aacatgtcta ctatttgtgt 15240 attcttctaa tggggtagct gtctccaatt tttgcgtaat ggattagtgc cactgtctag 15300 tagtagtttg acgacctcga cattattaca atgctcatta aaaaggtatg c gtgtaaagc 15360 attattcttg aattggttcc tggtatcatt aggatctctg tctctcaaca tctgtttaag 15420 ttcatcgaga gccacctcct cattttccaa atagtcaaac attttgactg aatgagctac 15480 tgtgaactct atacacccac acaactaatg tcattaaata tcatgtcaaa aacttgtaca 15540 attattaata aaaataattt agtgtttaaa ttttaccagt tccagatttt acacctccgt 15600 taaccccact ttttacacca ctggacgatc ctcctcccca cattccaccg ccaccagatg 15660 tataagtttt agatccttta ttactaccat catgtccatg gataaagaca ctccacatgc 15720 cgccactacc ccctttagaa gacatattaa taagacttaa ggacaagttt aacaataaaa 15780 ttaatcacga gtaccctact accaacctac actattatat gattatagtt tctattttta 15840 cagtacctta actaaagtct ctagtcacaa gagcaatact accaacctac actattatat 15900 gattatagtt tctattttta taggaacgcg tacgagaaaa tcaaatgtct aatttctaac 15960 ggtagtgttg ataaacgatt atcgtcaatg gatacctcct ctatcatgtc gtctattttc 16020 ttactttgtt ctattaactt attagcatta tatattattt gattataaaa cttatattgc 16080 ttattagccc aatctgtaaa tatcggatta ttaacatatc gtttctttgt aggtttattt 16140 aacatgtaca tcactgtaag catgtccgta ccatttattt taat ttgacg catatccgca 16200 atttcttttt cgcagtcggt tataaattct atatatgatg gatacatgct acatgtgtac 16260 ttataatcga ctaatatgaa gtacttgata catattttca gtaacgattt attattacca 16320 cctatgaata agtacctgtg atcgtctagg taatcaactg ttttcttaat acattcgatg 16380 gttggtaatt tactcagaat aatttccaat atcttaatat ataattctgc tatttctggg 16440 atatatttat ctgccagtat aacacaaata gtaatacatg taaacccata ttttgttatt 16500 atattaatgt ctgcgccatt atctattaac cattctacta ggctgacact atgcgactta 16560 atacaatgat aaagtatact acatccatgt ttatatcatc aatatacggc ttacaaagtt 16620 ttagtatcga taacacatcc aactcacgca tagagaaggt agggaataat ggcataatat 16680 ttattaggtt atcatcattg tcattatcta caactaagtt tccatttttt aaaatatact 16740 cgacaacttt aggatctcta ttgccaaatt tttgaaaata tttatttata tgcttaaatc 16800 tatataatgt agctccttca tcaatcatac atttaataac attgatgtat actgtatgat 16860 aagatacata ttctaacaat agatcttgta tagaatctgt atatctttta agaattgtgg 16920 atattattac gtaaactatt acacaattct aaaatataaa acgtatcacg gtcgaataat 16980 agttgatcaa ctatataatt atcgattttg tgatttt tct tcctaaactg tttacgtaaa 17040 tagttagata gaatattcat tagttcatga ccactatagt tactatcgaa taacgcgtca 17100 aatatttccc gtttaatatc gcatttgtca agataataat agagtgtggt atgttcacga 17160 taagtataat aacgcatctc tttttcgtgt gaaattaaat agtttattac gtccaaagat 17220 gtagcataac catcttgtga cctagtaata atataataat agagaactgt tttacccatt 17280 ctatcatcat aatcagtggt gtagtcgtaa tcgtaattgt ctaattcatc atcccaatta 17340 taatattcac cagcacgtct aatctgttct attttgatct tgtatccata ctgtatgttg 17400 ctacatgtag gtattccttt atccaataat agtttaaaca catctacatt gggatttgat 17460 gttgtagcgt atttttctac aatattaata ccatttttga tactatttat ttctatacct 17520 ttcgaaatta gtaatttcaa taagtctata tcgatgttat cagaacatag atattcgagt 17580 atatcaaaat cattgatatt tttatagtcg actgacgaca ataacaaaat cacaacatcg 17640 tttttgatat tattattttt cttggtaacg tatgccttta atggagtttc accatcatac 17700 tcatataatg gatttgcacc actttctatc aatgattgtg cactgctggc atcgatgtta 17760 aatgttttac aactatcata gagtatctta tcgttaacca tgattggttg ttgatgctat 17820 cgcatttttt ggtttctttc atttcagtta tgtatggatt tagcacgttt gggaagcatg 17880 agctcatatg atttcagtac tgtagtgtca gtactattag tttcaataag atcaatctct 17940 agatctatag aatcaaaaca cgataggtca gaagataatg aatatctgta ggcttcttgt 18000 tgtactgtaa cttctcgttt tgttagatgt ttgcatcgtg ctttaacatc aatggtacaa 18060 attttatcct cgctttgtgt atcatattcg tccctactat aaaattgtat attcagatta 18120 tcatgagatg tgtatacgct aacggtatca ataaacggag cacaccattt agtcataacc 18180 gtaatccaaa aatttttaaa gtatatctta acgaaagaag ttgtgtcatt gtctacggtg 18240 tatggtacta gatcctcata agtgtatata tctagagtaa tgtttaattt atcaaatggt 18300 tgataatatg gatcctcatg acaatttccg aagatggaaa tgagatatag acatgcaata 18360 aatctaattg cggacatggt tactccttaa aaaaatacga ataatcacct tggctattta 18420 gtaagtgtca tttaacacta tactcatatt aatccatgga ctcataatct ctatacggga 18480 ttaacggatg ttctatatac ggggatgagt agttttcttc tttaacttta tactttttac 18540 taatcatatt tagactgatg tatgggtaat agtgtttaaa gagttcgttc tcatcatcag 18600 aataaatcaa tatctctgtt tttttgttat acagatgtat tacagcctca tatattacgt 18660 aatagaacgt gtcatctacc tt attaactt tcaccgcata gttgtttgca aatacggtta 18720 atcctttgac ctcgtcgatt tccgaccaat ctgggcgtat aatgaatcta aactttaatt 18780 tcttgtaatc attcgaaata atttttagtt tgcatccgta gttatcccct ttatgtaact 18840 gtaaatttct caacgcgata tctccattaa taatgatgtc gaattcgtgc tgtataccca 18900 tactgaatgg atgaacgaat accgacggcg ttaatagtaa tttacttttt catctttaca 18960 tattgggtac tagttttact atcataagtt tataaattcc acaagctact atggaataag 19020 ccaaccatct tagtataaca cacatgtctt aaagtttatt aattaattac atgttgtttt 19080 atatatcgct acgaatttaa acagagaaat cagtttagga aaaaaaaata tctatctaca 19140 tcatcacgtc tctgtattct acgatagagt gctactttaa gatgagacat atccgtgtca 19200 tcaaaaatat actccattaa aatgattatt ccggcagcga acttgatatt ggatatatca 19260 caacctttgt taatatctac gacaatagac agcagtccca tggttccata aacagtgagt 19320 ttatctttct ttgaagagat attttgtaga gatcttataa aactgtcgaa tgacatcgca 19380 tttatatctt tagctaaatc gtatatgtta ccatcgtaat atctaaccgc gtctatctta 19440 aacgtttcca tcgctttaaa gacgtttccg atagatggtc tcatttcatc agtcatactg 19500 agccaacaaa tataa tcgtg tataacatct ttgatagaat cagactctaa agaaaacgaa 19560 tcggctttat tatacgcatt catgataaac ttaatgaaaa atgtttttcg ttgtttaagt 19620 tggatgaata gtatgtctta ataattgtta ttatttcatt aattaatatt tagtaacgag 19680 tacactctat aaaaacgaga atgacataac tagttatcaa agtgtctagg acgcgtaatt 19740 ttcatatggt atagatcctg taagcattgt ctgtattctg gagctatttt ctctatatct 19800 aatttctgaa cgttcaccaa tgtctctagc cactttggca ctaatagcga tcattcgctt 19860 agcgtcttct atattattaa ctggttgatt caatctatct agcaatggac cgtcggacag 19920 cgtcattctc atgttcttaa tcaatgtaca tacatcgccg tcatctacca attcatccaa 19980 caacataagc tttttaaaat catcattata ataggtttga tcgttgtcat ttctccaaag 20040 aatatatcta ataagtagag tcctcatgat tagttaacaa ctatttttta tgttaaatca 20100 attagtacac cgctatgttt aatacttatt catattttag tttttaggat tgagaatcaa 20160 tacaaaaatt aatgcatcat taattttaga aatacttagt ttccacgtag tcaatgaaac 20220 atttgaactc atcgtacagg acgttctcgt acaggacgta actataaacc ggtttatatt 20280 tgttcaagat agatacaaat ccgataactt tttttacgaa ttctacggga tccactttaa 20340 aagtgtca ta ccgggttctt tttatttttt taaacagatt aatggtgtga tgttgattag 20400 gtcttttacg aatttgatat agaatagcgt ttacatattc tccataatgg tcaatcgcca 20460 tttgttcgta tgtcataaat tctttaatta tatgacactg tgtattattt agttcatcct 20520 tgttcatcat taggaatcta tccaatatgg caattatact agaactatag gtgcgttgta 20580 tacacatatt gatgtgtctg tttatacaat ccatgctact accttcgggt aaaattgtag 20640 catcatatac catttctagt actttaggtt cattgttatc cattgcagag gacgtcatga 20700 acgcatccta aaaaaatata ttatttttat gttattttgt taaaaataat catcgaatac 20760 gaatcatcca gtccactgaa tagcaaaatc tttactattt tggtatcttc caatgtggct 20820 gcctgatgta atggaaattc attctctaga agatttttca atgctccagc gttcaacaac 20880 gtacatacta gacgcacgtt attatcagct attgcataat acaaggcact atgtccatgg 20940 acatccgcct taaatgcatc tttgctagag agaaagcttt tcagctgctt agacttccaa 21000 gtattaattc gtgacagatc catgtctgaa acgagacgct aattagtgta taatttttgt 21060 catattgcac cagaattaat aatatctcta atagatctga ttagtagata catggctatc 21120 gcaaaacaac atatacacat ttaataaaaa taatatttat taagaaaatt cagatttcac 21180 gtacccatca atataaataa aataatgatt ccttacaccg tacccatatt aaggagattc 21240 taccttaccc ataaacaata taaatccagt aatatcatgt ctgatgatga acacaaatgg 21300 tgtattaaat tccagttttt caggagatga tctcgccgta gctaccataa tagtagatgc 21360 ctctgctaca gttccttgtt cgtcgacatc tatctttgca ttctgaaaca ttttataaat 21420 atataatggg tccctagtca tatgtttaaa cgacgcatta tctggattaa acatactagg 21480 agccatcatt tcggctatcg acttaatatc cctcttattt tcgatagaaa atttagggag 21540 tttaagattg tacactttat tccctaattg aaacgaccaa tagtctaatt ttgcagccgt 21600 aatagaatct gtgaaatggg tcatattatc acctattgcc aggtacatac taatattagc 21660 atccttatac ggaaggcgta ccatgtcata ttctttgtca tcgattgtga ttgtatttcc 21720 ttgcaattta gtaactacgt tcatcatggg aaccgttttc gtaccgtact tattagtaaa 21780 actagcattg cgtgttttag tgatatcaaa cggatattgc catatacctt taaaatatat 21840 agtattaatg attgcccata gagtattatt gtcgagcata ttagaatcta ctacattaga 21900 cataccggat ctacgttcta ctatagaatt aattttatta accgcatctc gtctaaagtt 21960 taatctatat aggccgaatc tatgatattg ttgataatac gacggtttaa tacacacag t 22020 attatctacg aaactttgat aagttagatc agtgtacgta tatttagatg ttttcagctt 22080 agctaatcct gatattaatt ctgtaaatgc tggacccaga tctctttttc tcaaatccat 22140 agtcttcaat aattctattc tagtattacc tgatgcaggc aatagcgaca taaacataga 22200 aaacgaataa ccaaacggtg agaagacaat attatcatct tgaatatttt tatacgctac 22260 tataccggca ttggtaaatc cttgtagacg ataggtagac gctgaacacg ttaacgatag 22320 tatcaataac gcaatcatga ttttatggta ttaataatta accttatttt tatgttcggt 22380 ataaaaatta ttgatgtcta cacatccttt tgtaattgac atctatatat ccttttgtat 22440 aatcaactct aatcacttta acttttacag ttttccctac cagtttatcc ctatattcaa 22500 catatctatc catatgcatc ttaacactct ctgccaagat agcttcagag tgaggatagt 22560 caaaaagata aatatataga gcataatcat tctcgtatac tctgcccttt attacatcgc 22620 ccgcattggg caacgaataa caaaatgcaa gcatcttgtt aacgggctcg taaattggga 22680 taaaaattat gtttttatat ctattttatt caagagaata ttcaggaatt tctttttccg 22740 gttgtatctc atcgcagtat atatcatttg tacattgttt catatttttt aatagtttac 22800 accttttagt aggactagta tcgtacaatt catagctgta ttttgaattc c aatcacgca 22860 taaaaatatc ttctaattgt tgacgaagac ctaatccatc atccggtgta atattaatag 22920 atgctccaca tgtatccgta aagtaatttc ctgtccaatt tgaggtacct atataggccg 22980 ttttatcggt taccatatat ttggcatggt ttaccctaga atacggaatg ggaggatcag 23040 catctggtac aataaatagc tttacttcta tatttatgtt tttagatttt agcatagcga 23100 tagatcttaa aaagtttctc atgataaacg aagatcgttg ccagcaacta atcaatagct 23160 taacggatac ttgtctgtct atagcggatc ttcttaattc atcttctata taaggccaaa 23220 acaaaatttt acccgccttc gaataaataa tagggataaa gttcataaca gatacataaa 23280 cgaatttact cgcatttcta atacatgaca ataaagcggt taaatcattg gttctttcca 23340 tagtacatag ttgttgcggt gcagaagcaa taaatacaga gtgtggaaca ccacttacgt 23400 taatactaag aggatgatct gtattataat acgacggata aaagtttttc caattatatg 23460 gtagattgtt aactccaaga taccagtata cctcaaaaat ttgagtgaga tccgctgcca 23520 agttcctatt attgaagatc gcaataccca attctttgac ctgagttagt gatctccaat 23580 ccatgttagc gcttcctaaa taaatatgtg tattatcaga tatccaaaat tttgtatgaa 23640 gaactcctcc taggatattt gtaatatcta tgtatcgtac ttca actccg gccatttgta 23700 gtctttcaac atcctttaat ggtttgttag atttattgac ggctactcta actcgtactc 23760 ctcttttggg taattgtaca atctcgttta atattatcgt gccgaaattc gtacccactt 23820 catccgataa actccaataa aaagatgata tatctagtgt ttttgtggta ttggatagaa 23880 tttccctcca catgttaaat gtagacaaat atactttatc aaattgcata cctataggaa 23940 tagtctctgt aatcactgcg attgtattat ccggattcat tttatttgtt aaaagaataa 24000 tcctatatca cttcactcta ttaaaaatcc aagtttctat ttctttcatg actgattttt 24060 taacttcatc cgtttcctta tgaagatgat gtttggcacc ttcataaatt tttatttctc 24120 tattacaatt tgcatgttgc atgaaataat atgcacctaa aacatcgcta atctcattgt 24180 ttgttccctg gagtatgaga gtcggggtgt taatcttgga aattattttt ctaaccttgt 24240 tggtagcctt caagacctga ctagcaaatc cagccttaat tttttcatga ttgattaatg 24300 ggtcgtattg gtatttataa actttatcca tatctctaga tactgattct ggacatagct 24360 ttccgactgg cgcatttggt gtgatggttc ccataagttt ggcagctagc agattcagtc 24420 ttgaaacagc atctgcatta actagaggag acattagaat cattgctgta aacaagtttg 24480 gattatcgta agaggctagt atagaaattg ttgctcc cat ggaatgaccc aataagtaga 24540 tttaatagtt accacgtgct gtaccaaagt catcaatcat cattttttca ccattacttc 24600 ttccatgtcc aatatgatca tgtgagaata ctaaaattcc taacgatgat atgttttcag 24660 ctagttcgtc ataacgtcca gaatgtttac cagctccatg acttatgaat actaatgcct 24720 taggatatgt aatcattgtc cagattgaac atacagtttg cactcatgat tcacgttata 24780 taactatcaa tattaacagt tcgtttgatg atcatattat ttttatgttt tattgataat 24840 tgtaaaaaca tacaattaaa tcaatataga ggaaggagac ggctactgtc ttttgtgaga 24900 tagtcatggc gactaaatta gattatgagg atgctgtttt ttactttgtg gatgatgata 24960 aaatatgtag tcgcgactcc atcatcgatc taatagatga atatattacg tggagaaatc 25020 atgttatagt gtttaacaaa gatattacca gttgtggaag actgtacaag gaattgatga 25080 agttcgatga tgtcgctata cggtactatg gtattgataa aattaatgag attgtcgaag 25140 ctatgagcga aggagaccac tacatcaatt ttacaaaagt ccatgatcag gaaagtttat 25200 tcgctaccat aggaatatgt gctaaaatca ctgaacattg gggatacaaa aagatttcag 25260 aatctagatt ccaatcattg ggaaacatta cagatctgat gaccgacgat aatataaaca 25320 tcttgatact ttttctagaa aaaaaattga attgatgata taggggtctt cataacgcat 25380 aattattacg ttagcattct atatccgtgt taaaaaaaat tatcctatca tgtatttgag 25440 agttttatat gtagcaaaca tgatagctgt gatgccaata agctttagat attcacgcgt 25500 gctagtgtta gggatggtat tatctggtgg tgaaatgtcc gttatataat ctacaaaaca 25560 atcatcgcat atagtatgcg atagtagagt aaacattttt atagttttta ctggattcat 25620 acatcgtcta cccaattcgg ttatgaatga aattgtcgcc aatcttacac ccaacccctt 25680 gttatccatt agtatagtat taacttcgtt atttatgtca taaactgtaa atgattttgt 25740 agatgccata tcatacatga tattcatgtc cctattataa tcattactaa ctttatcaca 25800 atatatgttg ataatatcta tatatgatct agtctttgtg ggcaactgtc tatacaagtc 25860 gtctaaacgt tgtttactca tatagtatcg aacagccatc attacatggt cccgttccgt 25920 tgatagataa tcgagtatgt tagtggactt gtcaaatcta tataccatat tttctggaag 25980 tggatataca tagtcgtgat caacattatt gctagcctca tcttctatat cctgtactat 26040 accatctaca taatctacga tattattaca cataaacatc gacaacatac tattgtttat 26100 tatctaagtc ctgttgatcc aaacccttga tctcctctat ttgtactatc tagagattgt 26160 acttcttcca gttctggata at atatacgt tgatagatta gctgagctat tctatctcca 26220 gtatttacat taaacgtaca ttttccatta ttaataagaa tgactcctat gtttccccta 26280 taatcttcgt ctattacacc acctcctata tcaatgcctt ttagtgacag accagaccta 26340 ggagctattc taccatagca aatcttaggc atggacatac taatatctgt cttaattaac 26400 tgtctttctc ctggagggat agtataatcg taagcgctat acaaatcata tccggcagca 26460 cccggcgatt gcctagtagg agatttagct ctgttagttt ccttaacaaa tctaactggt 26520 gagttaatat tcatgttgaa cataaaacta atattttatt tcaaaattat ttaccatccc 26580 atatattcca tgaataagtg tgatgattgt acacttctat agtatctata tacgattcac 26640 gataaaatcc tcctatcaat agcagtttat tatccactat gatcaattct ggattatccc 26700 tcggataaat aggatcatct atcagagtcc atgtattgct ggattcacaa taaaattccg 26760 catttctacc aaccaagaat aaccttctac cgaacactaa cgcgcatgat ttataatgag 26820 gataataagt ggatggtcca aactgccact gatcatgatt gggtagcaaa tattctgtag 26880 ttgtatcagt ttcagaatgt cctcccatta cgtatataac attgtttatg gatgccactg 26940 ctggattaca tctaggtttc agaagactcg gcatattaac ccaagcagca tccccgtgga 27000 accaacgctc aacag atgtg ggatttggta gacctcctac tacgtataat ttattgttag 27060 cgggtatccc gctagcatac agtctggggc tattcatcgg aggaattgga atccaattgt 27120 ttgatatata atttacagct atagtacattacgt tatgtattatttt tacctatacgt tatgtattatttc tacctata 27ttcat gatccatgtt cataggatac tctatgaatg gatacttgta tgatttgcgt ggttgtttat 27300 cacaatgaaa tattttggta cagtctagta tccattttac attatttata cctctgggag 27360 aaagataatt tgacctgatt acatttttga taaggagtag cagatttcct aatttatttc 27420 ttcgctttat ataccactta atgacaaaat cctcatctgg aacatttagt tcatcgcttt 27480 ctagaataag tttcatagat agataatcaa aattgtctat gatgtcatct tccagttcca 27540 aaaagtgttt ggcaataaag tttttagtat gacataagag attggatagt ccgtattcta 27600 tacccatcat gtaacactcg acacaatatt cctttctaaa atctcgtagg ataaagttta 27660 tacaagtgta gatgataaat tctacagagg ttaatataga agcacgtaat aaattgacga 27720 cgttatgact atctatatat acctttccag tatatgagta aataactata gaagttagac 27780 tgtgaatgtc aaggtctaga caaaccctcg taactggatc tttatttttc gtgtattttt 27840 gacgtaaatg tgtgcgaaag taaggagata actttttcaa tatcgtagaa ttgactatta 27900 tattgcctcc tatggcatca ataattgttt tgaatttctt agtcatagac aatgctaata 27960 tattcttaca gtacacagta ttgacaaata tcggcattta tgtttcttta aaagtcaaca 28020 tctaaagaaa aatgattatc ttcttgagac ataactccca ttttttggta ttcacccac a 28080 cgtttttcga aaaaattagt tttaccttct aatgatatat tttccatgaa atcaaacgga 28140 ttggtaacat tataaatttt tttaaatccc aattcagaaa tcaatctatc cgcgacgaat 28200 tctatatatg ttttcatcat ttcacaattc attcctataa gtttaactgg aagagccgca 28260 gtaagaaatt cttgttcaat ggataccgca tctgttataa tagatctaac ggtttcttca 28320 ctcggtggat gcaataaatg tttaaacatc aaacatgcga agtcgcagtg tagaccctcg 28380 tctctactaa tcaattcgtt ggaaaacgtg agtccgggca ttaggccacg ctttttaagc 28440 caaaatatgg aagcgaatga tccggaaaag aagattcctt ctactgcagc aaaggcaata 28500 agtctctctc cataaccggc gctgtcatgt atccactttt gagcccaatc ggccttcttt 28560 tttacacaag gcatcgtttc tatggcatta aagagatagt ttttttcatt actatcttta 28620 acataagtat cgatcaaaag actatacatt tccgaatgaa tgttttcaat ggccatctga 28680 aatccgtaga aacatctagc ctcggtaatc tgtacttctg tacaaaatcg ttccgccaaa 28740 ttttcattca ctattccgtc actggctgca aaaaacgcca atacatgttt tataaaatat 28800 ttttcgtctg gtgttagttt attccaatca ttgatatctt tagatatatc tacttcttcc 28860 actgtccaaa atgatgcctc tgccttttta tacatgttcc agatgtcatg a tattggatt 28920 gggaaaataa caaatctatt tggatttggt gcaaggatgg gttccataac taaattaaca 28980 ataacaataa attttttttc agttatctat atgcctgtac ttggatcttt tgtacatcga 29040 tatcgccgca atcactacaa taattacaag tattattgat agcattgtta ttagtactat 29100 cataattaaa ttatcgttat tatcattttg taattgtgac atcatactag ataaatcgtt 29160 tgcgagattg ttgtgggaag cgggcatgga ggatgaatta tcgttattat tatttaaagc 29220 ctcccattcg gattcacaaa tatggcgcgc gttcaacatt ttatggaaac agataacaag 29280 aaaactcgtc atcgttcaaa tttttaacga tagtaaaccg attaaacgtc gagctaattt 29340 ctaacgctag cgactctgtt ggatatgggt ttccagatat atatcttttc agttccccta 29400 cgtatctata atcatctgta ggaaatggaa gatatttcca tttatctact gttcctaata 29460 tcatatgtgg tggtgtagta gaaccattaa gcgcgaaaga tgttatttcg catcgtattt 29520 taacttcgca ataatttctg gttagataac gcactctacc agtcaagtca atgatattag 29580 cctttacaga tatattcata gtagtcgtaa cgatgactcc atcttttaga tgcgatactc 29640 ctttgtatgt accagaatct tcgtacctca aactcgatat atttaaacaa gttaatgaga 29700 tattaacgcg ttttatgaat gatgatatat aaccagaagt ttta tcctcg gtggctagcg 29760 ctataacctt atcattataa taccaactag tgtgattaat atgtgacacg ttagtgtggg 29820 tacaaatatg tacattatcg tctacgtcgt attcgataca tccgcataca gccaacaaat 29880 ataaaatgac aaatactcta acgccgttcg tacccatctt gatgcggttt aataaatgtt 29940 ttgatttcaa tttattgtaa aaaaagattc ggttttatac tgttcgatat tctcattgct 30000 tatattttca tctatcatct ccacacagtc aaatccgtgg ttagcatgca cctcatcaac 30060 cggtaaaaga ctatcggact cttctatcat tataactcta gaatatttaa tttggtcatt 30120 attaatcaag tcaattatct tatttttaac aaacgtgagt attttactca ttttttataa 30180 aaacttttag aaatatacag actctatcgt gtgtctatat cttcttttta tatccaatgt 30240 atttatgtct gatttttctt catttatcat atataatggt ccaaattcta cacgtgcttc 30300 ggattcatcc agatcattaa ggttcttata attgtaacat ccttctcttc cctcttctac 30360 atcttccttc ttattcttat tcttagcgtc acagaatcta ccacagcagg atcccatgac 30420 gagcgtcata ttaaactaat ccattttcaa ttataatata cgattagtaa tgaccattaa 30480 aataaaaata ttcttcataa ccggcaagaa agtgaaaagt tcacattgaa actatgtcag 30540 tagtatacat catgaaatga tgatatatat atactct att ttggtggagg attatatgat 30600 ataattcgtg gataatcatt cttaagacac atttcttcat tcgtaaatct tttcacgtta 30660 aatgagtgtc catattttgc aatttcttca tatgatggcg gtgtacgtgg acgaggctgc 30720 tcctgttctt gttgtagtcg ccgactgtcg tgtctgcgtt tagatccctc cattatcgcg 30780 attgcgtaga tggagtacta ttttatacct tgtaattaaa tttttttatt aattaaacgt 30840 ataaaaacgt tccgtatctg tatttaagag ccagatttcg tctaatagaa caaatagcta 30900 cagtaaaaat aactagaata attgctacac ccactagaaa ccacggatcg taatacggca 30960 atcggttttc gataataggt ggaacgtata ttttatttaa ggacttaaca attgtctgta 31020 aaccacaatt tgcttccgcg gatcctgtat taactatctg taaaagcata tgttgaccgg 31080 gcggagccga acattctccg atatccaatt tctgtatatc tataatatta ttaacctccg 31140 catacgcatt acagttcttt tctagcttgg ataccgcact aggtacatcg tctagatcta 31200 ttcctatttc ctcagcgata gctcttctat ccttttccgg aagcaatgaa atcacttcaa 31260 taaatgattc aaccatgagt gtgaaactaa gtcgagaatt actcatgcat ttgttagtta 31320 ttcggagcgc gcaattttta aactgtccta taacctctcc tatatgaata gcacaagtga 31380 cattagtagg gatagaatgt tgagctaatt tttgtaaata actatctata aaaagattat 31440 acaaagtttt aaactcttta gtttccgcca tttatccagt ctgagaaaat gtctctcata 31500 ataaattttt ccaagaaact aattgggtga agaatggaaa cctttaatct atatttatca 31560 cagtctgttt tggtacacat gatgaattct tccaatgccg tactaaattc gatatctttt 31620 tcgatttctg gatatgtttt taataaagta tgaacaaaga aatggaaatc gtaataccag 31680 ttatgtttaa ctttgaaatt gttttttatt ttcttgttaa tgattccagc cacttgggaa 31740 aagtcaaagt cgtttaatgc cgatttaata cgttcattaa aaacaaactt tttatccttt 31800 agatgaatta ttattggttc attggaatca aaaagtaaga tattatcggg tttaagatct 31860 gcgtgtaaaa agttgtcgca gcatggtagt tcgtaaattt taatgtataa cagagccatc 31920 tgtaaaaaga taaactttat gtattgtacc aaagatttaa atcctaattt gatagctagc 31980 tcggtatcta ctttatctgc cgaatacagt gctaggggaa aaattataat atttcctctt 32040 tcgtattcgt agttagttct cttttcatgt tcgaaaaagt gaaacatgcg gttaaaatag 32100 tttataacat taatattact gttaataact gccggataaa agtgggatag taatttcacg 32160 aatttgatac tgtcctttct ctcgttaaac gcctttaaaa aaactttaga agaatatctc 32220 aatgatagtt cctgaccatc ca tagtttgt atcaataata gcaacatatg aagaacacgt 32280 ttatacagag tatgtaaaaa tgttaattta tagtttaatc ccatggccca cgcacacacg 32340 attaattttt tttcatctcc ctttagattg ttgtatagaa atttgggtac tgtgaactcc 32400 gccgtagttt ccatgggact atataatttt gtggcctcga atacaaattt tactacatag 32460 ttatctatct taaagactat accatatcct cctgtagata tgtgataaaa atcgtcgttt 32520 ataggataaa atcgtttatc cttttgttgg aaaaaggatg aattaatgta atcattctct 32580 tctatcttta gtagtgtttc cttattaaaa ttcttaaaat aatttaacaa tctaactgat 32640 ggagcccaat tttggtgtaa atctaattgg gacattatat tgttaaaata caaacagtct 32700 cctaatataa cagtatctga taatctatgg ggagacatcc attgatattc aggggatgaa 32760 tcattggcaa cacccattta ttgtacaaaa agccccaatt tacaaacgaa agtccaggtt 32820 tgatagagac aaactattaa ctattttgtc tctgttttta atttctttgg taatgaaatt 32880 attcacaata tcagtatctt ctttatctac cagagatttt actaacttga taaccttggc 32940 tgtctcattc aatagggtag taatatttgt atgtgtgata ttgatatctt ttagaagtga 33000 ttctttgatg gtgccagcat acgaattaca ataatgcaga aactcggtta acatgcagga 33060 attatagtaa gccaa ttcca attgttgcct gtgttgtatt agagtgtcaa tatgagcaat 33120 ggtgtccttg cgtttctctg atagaatgcg agcagcgatt ttggcgttat catttgacga 33180 tatttctgga atgacgaatc ctgtttctac taactttttg gtaggacaaa gtgaaacaat 33240 caagaagata gcttctcctc ctatttgtgg aagaaattga actcctctag atgatctcct 33300 tgacagatat tggaccgaat tacagaagta cctggaatgt aaagccctga aaccccctca 33360 ttttttaagc agattgttgc cgtaaatcct gcactatgcc caagatagag agctcctttg 33420 gtgaatccat ctctatgttt cagtttaacc aagaaacagt cagctggtct aaaatttcca 33480 tctctatcta atacagcatc taacttgatg tcaggaacta tgaccggtta tgttatatgt 33540 aacattgagt aaatccttaa gttcataatc atcactgtca tcagttatgt acgatccaaa 33600 caatgtttct actggcatag tggatacgaa gatgctatcc atcagaatgt ttccctgatt 33660 agtattttct atatagctat tcttctttaa acgattttcc aaatcagtaa ctatgttcat 33720 ttttttagga gtaggacgcc tagccagtat ggaagaggat tttctagatc ctctcttcaa 33780 catctttgat ctcaatggaa tgcaaaaccc catagtgtaa caaccaacga taaaaataat 33840 attgtttttc actttttata attttaccat ctgactcatg gattcattaa tatctttata 33900 agagctac ta acgtataatt ctttataact gaactgagat atatacaccg gatctatggt 33960 ttccataatt gagtaaatga atgctcggca ataactaatg gcaaatgtat aaaacaacga 34020 aattatacta gagttgttaa agttaatatt ttctatgagc tgttccaata aattatttgt 34080 tgtaactgcg ttcaagtcat aaatcatctt gatactatcc agtaaaccgt ttttaagttc 34140 tggaatatta ttatcccatt gtaaagcccc taattcgact atcgaatatc ctgctctgat 34200 agcagtttca atatcgacgg acgtcaatac tgtaataaag gtggtagtat tgtcatcatc 34260 gtgataaact actggaatat ggtcgttagt aggtacggta actttacaca acgcgatata 34320 taactttcct tttgtaccat ttttaacgta gttgggacgt cctgcagggt attgttttga 34380 agaaatgata tcgagaacag atttgatacg atatttgttg gattcctgat tatttactat 34440 aatataatct agacagatag atgattcgat aaatagagaa ggtatatcgt tggtaggata 34500 atacatcccc attccagtat tctcggatac tctattaatg acactagtta agaacatgtc 34560 ttctattcta gaaaacgaaa acatcctaca tggactcatt aaaacttcta acgctcctga 34620 ttgtgtctcg aatgcctcgt acaaggattt caaggatgcc atagattctt tgaccaacga 34680 tttagaattg cgtttagcat ctgatttttt tattaaatcg aatggtcggc tctctggttt 34740 gctaccccaa tgataacaat agtcttgtaa agataaaccg caagaaaatt tatacgcatc 34800 catccaaata accctagcac catcggatga tattaatgta ttattataga ttttccatcc 34860 acagttattg ggccagtata ctgttagcaa cggtatatcg aatagattac tcatgtaacc 34920 tactagaatg atagttcgtg tactagtcat aatatcttta atccaatcta agaaatttaa 34980 aattagattt tttacactgt taaagttaac aaaggtatta cccggatacg tggatatcat 35040 atatggtatt ggtccattat cagtaatagc tccataaact gatacggcga tggtttttat 35100 atgtgtttga tctaacgagg aagaaattcg cgcccacaat tcatctctag atatgtattt 35160 aatatcaaac ggtaacacat caatttcggg acgcgtatat gtttctaaat ttttaatcca 35220 aatataatga tgacctatat gccctattat catactgtca actatagtac acctagagaa 35280 cttacgatac atctgtttcc tataatcgtt aaattttaca aatctataac atgctaaacc 35340 ttttgacgac aaccattcat taatttctga tatggaatct gtattctcaa taccgtatcg 35400 ttctaaagcc agtgctatat ctccctgttc gtgagaacgc tttcgtataa tatcgatcaa 35460 cggataatct gaagtttttg gagaataata tgactcatga tctatttcgt ccataaacaa 35520 tctagacata ggaattggag gcgatgatct taattttgtg caatgagtcg tcaatccta t 35580 aacttctaat attgtaatat tcatcatcga cataacacta tctatgttat catcgtatat 35640 tagtatacca tgaccttctt catttcgtgc caaaatgata tacagtctta aatagttacg 35700 caatatctca atagtttcat aattgttagc tgttttcatc aaggtttgta tcctgtttaa 35760 catgatggcg ttctatacgt ttctattttt taaattttta acgatttact gtggctagat 35820 acccaatctc tctcaaatat ttttttagcc tcgcttacaa gctgtttatc tatactatta 35880 aaactgacga atccgtgatt ttggtaatgg gttccgtcga aatttgccga agtgatatga 35940 acatattcgt cgtcgactat caacaatttt gtattattct gaatagtgaa aaccttcaca 36000 gatagatcat tttgaacaca caacgcgtct agacttctgg cggttgccat agaatatacg 36060 tcgttcttat cccaattacc aactagaagt ctgatcttaa ctcctctatt aatggctgct 36120 tctataatgg agttgtaaat gtcgggccaa tagtagctat taccgtcgac acgtgtagtg 36180 ggaactatgg ccaaatgttc aatatctata ctagtcttag ccgacttgag tttatcaata 36240 actacatcag tgtctagatc tctagaatat cccaataggt gttccggaga atcagtaaag 36300 aacactccac ctataggatt cttaatatga tacgcagtgc taactggcag acaacaagcc 36360 gcagagcata aattcaacca tgaatttttt gcgctattaa aggctttaaa a gtatcaaat 36420 cttctacgaa gatctgtggc cagcggggga taatcagaat atacacctaa cgttttaatc 36480 gtatgtatag atcctccagt aaatgacgcg tttcctacat aacatctttc attatctgac 36540 acccaaaaac aaccgagtag tagtcccaca ttattttttt tatctatatt aacggttata 36600 aaatttatat ccgggcagtg actttgtagc tctcccagat ttcttttccc tcgttcatct 36660 agcaaaacta ttattttaat ccctttttca gatgcctctt ttagtttatc aaaaataagc 36720 gctcccctag tcgtactcag aggattacaa caaaaagatg ctatgtatat atatttctta 36780 gctagagtga taatttcgtt aaaacattca aatgttgtta aatgatcgga tctaaaatcc 36840 atattttctg gtagtgtttc taccagccta cattttgctc ccgcaggtac cggtgcaaat 36900 ggccacattt agttaacata aaaacttata catcctgttc tatcaacgat tctagaatat 36960 catcggctat atcgctaaaa ttttcatcaa agtcgacatc acaacctaac tcagtcaata 37020 tattaagaag ttccatgatg tcatcttcgt ctatttctat atccgtatcc attgtagatt 37080 gttgaccgat tatcgagttt aaatcattac taatactcaa tccttcagaa tacaatctgt 37140 gtttcattgt aaatttatag gcggtgtatt taagttggta gattttcaat tatgtatcaa 37200 tatagcaaca gtagttcttg ctcctccttg attctagcat cctc ttcatt attttcttct 37260 acgtacataa acatgtccaa tacgttagac aacacaccga cgatggcggc cgccacagac 37320 acgaatatga ctaaaccgat gaccatttaa aaacccctct ctagctttca cttaaactgt 37380 atcgattatt cttttagaac atgtataata taaaaacatt attctatttc gaatttaggc 37440 ttccaaaaat ttttcatccg taaaccgata ataatatata tagacttgtt aatagtcgga 37500 ataaatagat taatgcttaa actatcatca tctccacgat tagagataca atatttacat 37560 tttttttgct gtttcgaaac tttatcaata cacgttaata caaacccagg aaggagatat 37620 tgaaactgag gctgttgaaa atgaaacggt gaatacaata attcagataa tgtaaaatca 37680 tgattccgta ttctgatgat attagaactg ctaatggatg tcgatggtat gtatctagga 37740 gtatctattt taacaaagca tcgatttgct aatatacaat tatcattttg attaattgtt 37800 attttattca tattcttaaa aggtttcata tttatcaatt cttctacatt aaaaatttcc 37860 atttttaatt tatgtagccc cgcaatactc ctcattacgt ttcatttttt gtctataata 37920 tccattttgt tcatctcggt acatagatta tccaattgag aagcgcattt agtagttttg 37980 tacattttaa gtttattgac gaatcgtcga aaactagtta tagttaacat tttattattt 38040 gataccctga tattaatacc cctgccgtta ctattat tta taactgatgt aatccacgta 38100 acattggaat taactatcga tagtaatgca tcgacgcttc caaaattgtc tattataaac 38160 tcaccgataa tttttttatt acatgttttc atattcatta ggattattaa atctttaatc 38220 ttactacgat tgtatgcgtt gatattgcaa gacgtcattc taaaagacgg aggatctcca 38280 tcaaatgcca gacaatcacg tacaaagtac atggaaatag gttttgttct attgcgcatc 38340 atagatttat atagaacacc cgtagaaata ctaatttgtt ttactctata aaatactaat 38400 gcatctattt catcgttttg tataacgtct ttccaagtgt caaattccaa atttttttca 38460 ttgatagtac caaattcttc tatctcttta actacttgca tagataggta attacagtga 38520 tgcctacatg ccgttttttg aaactgaata gatgcgtcta gaagcgatgc tacgctagtc 38580 acaatcacca ctttcatatt tagaatatat atatgtaaaa atatagtaga atttcatttt 38640 gttttttttc tatgctataa atgaattctc attttgcatc tgctcatact ccgttttata 38700 tcaataccaa agaaggaaga tatctggttc taaaagccgt taaagtatgc gatgttagaa 38760 ctgtagaatg cgaaggaagt aaagcttcct gcgtactcaa agtagataaa ccctcatcac 38820 ccgcgtgtga gagaagacct tcgtcccctt ccagatgcga gagaatgaat aacccaggaa 38880 aacaagttcc gtttatgagg acggacatgc tacaaaatat gttcgcggct aatcgcgata 38940 atgtagcttc tagacttttg tcctaaaata caattatatc cttttcgata ttaataaatc 39000 cgtgtcgtcc aggtttttta tctctttcag tatgtgaata gataggtatt ttatctctat 39060 tcatcatcga atttaagaga tccgataaac attgtttgta ttctccagat gtcagcatct 39120 gatacaacaa tatatgtgca cataaacctc tggcacttat ttcatgtacc ttccccttat 39180 cactaaggag aatagtattt gagaaatatg tatacatgat attatcatga attagatata 39240 cagaatttgt aacactctcg aaatcacacg atgtgtcggc gttaagatct aatatatcac 39300 tcgataacac attttcatct agatacacta gacatttttt aaagctaaaa tagtctttag 39360 tagtaacagt aactatgcga ttattttcat cgatgataca tttcatcggc atattattac 39420 gcttaccatc aaagactata ccatgtgtat atctaacgta ttctagcatg gttgccatac 39480 gcgcattaaa cttttcagga tctttggata gatcttccaa tctatctatt tgagaaaaca 39540 tttttatcat gttcaatagt tgaaacgtcg gatccactat atagatatta tctataaaga 39600 ttttaggaac tacgttcatg gtatcctggc gaatattaaa actatcaatg atatgattat 39660 cgttttcatc ttttatcacc atatagtttc taagatatgg gattttactt aatataatat 39720 tatttcccgt aataaatttt at tagaaatg ccaaatctat aagaaaagtc ctcgaattag 39780 tttgaagaat atctatatcg ccgtaccgta tatttggatt aattagatat agagaatatg 39840 atccgtaaca tatacaactt ttattatggc gtctaagata ttcttccatc aacttattaa 39900 catttttgac tagggaagat acattatgac gtcccattac ttttgccttg tctattactg 39960 cgacgttcat agaatttagc atatctcttg ccaattcttc cattgatgtt acattataag 40020 aaattttaga tgaaattaca tttggagctt taatagtaag aactcctaat atgtccgtgt 40080 atgtggtcac taatacagat tgtagttcta taatcgtaaa taatttacct atattatatg 40140 tttgagtctg tttagaaaag tagctaagta tacgatcttt tatttctgat gcagatgtat 40200 caacatcgga aaaaaatctt tttttattct tttttactaa agatacaaat atgtctttgt 40260 taaaaacagt tattttctga atatttctag cttgtaattt taacatatga tattcgttca 40320 cactaggtac tctgcctaaa taggtttcta taatctttaa tgtaatatta ggaaaagtat 40380 tctgatcagg attcctattc attttgagga tttaaaactc tgattattgt ctaatatggt 40440 ctcaacacaa actttttcac agagcgatag agtttttgat aactcgtttt tcttaagaaa 40500 tataaaacta ctgtctccag agctcgctct atcttttatt ttatttaatt cgatacaaac 40560 tcctgatact ggttc agaaa gtaattcatt aattttcagt cctttataga agatatttaa 40620 tatagataat acaaaatctt cagtttttga tatcgatctg attgatccta gaactagata 40680 tattaataac gtgctgctcatta ggcagtttat gatatta tagattt 740 tatttagtata tattga tatta aaataaatcc aaaataacta gacattctat tttttgtgga ttagtgtact ctcttccctc 40860 tatcatgttc actactggtg tccacgatga taaatatcta gagggaatat aatatagtcc 40920 ataggatgcc aatctagcaa tgtcgaataa ctgtaatttt attcttcgct cttcattatg 40980 aattgattct tgaggtataa acctaacaca aattatatta ttagactttt cgtatgtaat 41040 gtctttcatg ttataagttt ttaatcctgg aatagaatct attttaatga ggcttttaaa 41100 cgcagagttc tccaacgagt caaagcataa tactctgttg gttttcttat atacgatgtt 41160 acgattttct tctttgaatg gaataggttt ttgaattagt ttataattac aacataatag 41220 ataaggaagt gtgcaaatag tacgcggaaa aaacataata gctcccctgt tttcatccat 41280 ggttttaagt aaatgatcac tggcttcttt agtcaatgga tattcgaaca ttaaccgttt 41340 catcatcatt ggacagaatc catatttctt aatgtaaaga gtgatcaaat cattgtgttt 41400 attgtaccat cttgttgtaa atgtgtattc ggttatcgga tctgctcctt tttctattaa 41460 agtatcgatg tcgatctcgt ctaagaattc aactatatcg acatatttca tttgtataca 41520 cataaccatt actaacgtag aatgtatagg aagagatgta acgggaacag ggtttgttga 41580 ttcgcaaact attctaatac ataattcttc tgttaatacg tcttgcacgt aatctatta t 41640 agatgccaag atatctatat aattattttg taagatgatg ttaactatgt gatctatata 41700 agtagtgtaa taattcatgt atttcgatat atgttccaac tctgtctttg tgatgtctag 41760 tttcgtaata tctatagcat cctcaaaaaa tatattcgca tatattccca agtcttcagt 41820 tctatcttct aaaaaatctt caacgtatgg aatataataa tctattttac ctcttctgat 41880 atcattaatg atatagtttt tgacactatc ttctgtcaat tgattcttat tcactatatc 41940 taagaaacgg atagcgtccc taggacgaac tactgccatt aatatctcta ttatagcttc 42000 tggacataat tcatctatta taccagaatt aatgggaact attccgtatc tatctaacat 42060 agttttaaga aagtcagaat ctaagacctg atgttcatat attggttcat acatgaaatg 42120 atctctattg atgatagtga ctatttcatt ctctgaaaat tggtaactca ttctatatat 42180 gctttccttg ttgatgaagg atagaatata ctcaatagaa tttgtaccaa caaactgttc 42240 tcttatgaat cgtatatcat catctgaaat aatcatgtaa ggcatacatt taacaattag 42300 agacttgtct cctgttatca atatactatt cttgtgataa tttatgtgtg aggcaaattt 42360 gtccacgttc tttaattttg ttatagtaga tatcaaatcc aatggagcta cagttcttgg 42420 cttaaacaga tatagttttt ctggaacgaa ttctacaaca ttattataaa g gactttggg 42480 tagataagtg ggatgaaatc ctattttaat taatgcgata gccttgtcct cgtgcagata 42540 tccaaacgct tttgtgatag tatggcattc attgtctaga aacgctctac gaatatctgt 42600 gacagatatc atctttagag aatatactag tcgcgttaat agtactacaa tttgtatttt 42660 ttaatctatc tcaataaaaa aattaatatg tatgattcaa tgtataacta aactactaac 42720 tgttattgat aactagaatc agaatctaat gatgacgtaa ccaagaagtt tatctactgc 42780 caatttagct gcattatttt tagcatctcg tttagatttt ccatctgcct tatcgaatac 42840 tcttccgtcg atatctacac aggcataaaa tgtaggagag ttactaggcc ccactgattc 42900 aatacgaaaa gaccaatctc tcttagttat ttggcagtac tcattaataa tggtgacagg 42960 gttagcatct ttccaatcaa taattttttt agccggaata acatcatcaa aagacttatg 43020 atcctctctc attgattttt cgcgggatac atcatctatt atggcgtcag ccataacatc 43080 agcatccggc ttatccgcct ccgttgtcat aaaccaacga ggaggaatat cgtcggagct 43140 gtacaccata gcactacgtt gaagatcgta cagagcttta ttaacttctc gcttctccat 43200 attaagttgt ctagttagtt gtgcagcagt agctccttcg attccaatgt ttttaatagc 43260 cgcacacaca atctctgcgt cagaacgctc gtcaatatag atct tagaca tttttagaga 43320 gaactaacac aaccagcaat aaaactaatt tattttatca tttttttatt catcatcctc 43380 tggtggttcg tcgtttctat cgaatgtgga tctgattaac ccgtcatcta taggtgatgc 43440 tggttctgga gattctggag gagatggatt attatctgga agaatctctg ttatttcctt 43500 gttttcatgt atcgattgcg ttgtaacatt aagattgcga aatgctctaa atttgggagg 43560 cttaaagtgt tgtttgcaat ctctacacgc atgtctaact agtggaggtt cgtcagcggc 43620 tctagtttga atcatcatcg gcgtagtatt cctactttta cagttaggac acggtgtatt 43680 gtatttctcg tcgagaacgt taaaataatc gttgtaactc acatccttta ttttatctat 43740 attgtattct actcctttct taatgcattt tataccgaat aagagatagc gaaggaattc 43800 tttttcggtg ccgctagtac ccttaatcat atcacatagt gttttatatt ccaaatttgt 43860 ggcaatagac ggtttatttc tatacgatag tttgtttctg gaatcctttg agtattctat 43920 accaatatta ttctttgatt cgaatttagt ttcttcgata ttagattttg tattacctat 43980 attcttgatg tagtactttg atgatttttc catggcccat tctattaagt cttccaagtt 44040 ggcatcatcc acatattgtg atagtaattc tcggatatca gtagcggcta ccgccattga 44100 tgtttgttca ttggatgagt aactactaat gtataca ttt tccatttata acacttatgt 44160 attaactttg ttcatttata ttttttcatt attatgttga tattaacaaa agtgaatata 44220 tatgttaata attgtattgt ggttatacgg ctacaatttc ataatgagtg gaagtcagtg 44280 tccgatgatc aatgacgata gctttactct gaaaagaaag tatcaaatcg atagtgcgga 44340 gtcaacaata aaaatggata agaagaggat aaagtttcag aatagagcca aaatggtaaa 44400 agaaataaat cagacaataa gagcagcaca aactcattac gagacattga aactaggata 44460 cataaaattt aagagaatga ttaggactac tactctagaa gatatagcac catctattcc 44520 aaataatcag aaaacttata aactattctc ggacatttca gccatcggca aagcatcaca 44580 gaatccgagt aagatggtat atgctctgct gctttacatg tttcccaatt tgtttggaga 44640 tgatcataga ttcattcgtt atagaatgca tccaatgagt aaaatcaaac acaagatctt 44700 ctctcctttc aaacttaatc ttattagaat attagtggaa gaaagattct ataataatga 44760 atgcagatct aataaatgga gaataattgg aacacaagtt gataaaatgt tgatagctga 44820 atctgataaa tatacaatag atgcaaggta taacctaaaa cccatgtata gaatcaaggg 44880 aaaatctgaa gaagataccc tctttatcaa acagatggta gaacaatgtg tgacatccca 44940 ggaattggtg gaaaaagtgt tgaagatact gtttagagat ttgttcaaga gtggagaata 45000 caaagcgtac agatacgatg atgatgtaga aaatggattt attggattgg atacactaaa 45060 attaaacatt gttcatgata tagttgaacc atgtatgcct gttcgtaggc cagtggctaa 45120 gatactgtgt aaagaaatgg taaataaata ctttgagaat ccgctacata ttattggtaa 45180 aaatcttcaa gagtgcattg actttgttag tgaataggca tttcatcttt ctccaatact 45240 aattcaaatt gttaaattaa taatggatag tataaatagt tattagtgat aaaatagtaa 45300 aaataattat tagaataaga gtgtagtatc atagataact ctcttctata aaaatggatt 45360 ttattcgtag aaagtatctt atatacacag tagaaaataa tatagatttt ttaaaggatg 45420 atacattaag taaagtaaac aattttaccc tcaatcatgt actagctctc aagtatctag 45480 ttagcaattt tcctcaacac gttattacta aggatgtatt agctaatacc aatttttttg 45540 ttttcataca tatggtacga tgttgtaaag tgtacgaagc ggttttacga cacgcatttg 45600 atgcacccac gttgtacgtt aaagcattga ctaagaatta tttatcgttt agtaacgcaa 45660 tacaatcgta caaggaaacc gtgcataaac taacacaaga tgaaaaattt ttagaggttg 45720 ccgaatacat ggacgaatta ggagaactta taggcgtaaa ttatgactta gttcttaatc 45780 cattatttca cggaggggaa cc catcaaag atatggaaat cattttttta aaactgttta 45840 agaaaacaga cttcaaagtt gttaaaaaat taagtgttat aagattactt atttgggctt 45900 acctaagcaa gaaagataca ggcatagagt ttgcggataa tgatagacaa gatatataca 45960 ctctatttca acaaactggt agaatagtcc atagcaatct aacagaaacg tttagagatt 46020 atatctttcc cggagataag actagctatt gggtgtggtt aaacgaaagt atagctaatg 46080 atgcggatat tgttcttaat agacacgcca ttaccatgta tgataaaatt cttagttata 46140 tatactctga gataaaacaa ggacgcgtta ataaaaacat gcttaagtta gtttatatct 46200 ttgagcctga aaaagatatc agagaacttc tgctagaaat catatatgat attcctggag 46260 atatcctatc tattattgat gcaaaaaacg acgattggaa aaaatatttt attagttttt 46320 ataaagctaa ttttattaac ggtaatacat ttattagtga tagaacgttt aacgaggact 46380 tattcagagt tgttgttcaa atagatcccg aatatttcga taatgaacga attatgtctt 46440 tattctctac gagtgctgcg gacattaaac gatttgatga gttagatatt aataacagtt 46500 atatatctaa tataatttat gaggtgaacg atatcacatt agatacaatg gatgatatga 46560 agaagtgtca aatctttaac gaggatacgt cgtattatgt taaggaatac aatacatacc 46620 tgtttttgca cgagt cggat cccatggtca tagagaacgg aatactaaag aaactgtcat 46680 ctataaaatc caagagtaga cggctgaact tgtttagcaa aaacatttta aaatattatt 46740 tagacggaca attggctcgt ctaggtcttg tgttagatga ttataaagga gacttgttag 46800 ttaaaatgat aaaccatctt aagtctgtgg aggatgtatc cgcattcgtt cgattttcta 46860 cagataaaaa ccctagtatt cttccatcgc taatcaaaac tattttagct agttataata 46920 tttccatcat cgtcttattt caaaggtttt tgagagataa tctatatcat gtagaagaat 46980 tcttggataa aagcatccat ctaaccaaga cggataagaa atatatactt caattgataa 47040 gacacggtag atcatagaac agaccaaata tattattaat aatttgtata tacatagata 47100 taattatcac acatttttga taaatgggaa ctgctgcaac aattcagact cccaccaaat 47160 taatgaataa agaaaatgca gaaatgattt tggaaaaaat tgttgatcat atagttatgt 47220 atattagtga cgaatcaagt gattcagaaa ataatcctga atatattgat tttcgtaaca 47280 gatacgaaga ctatagatct ctcattataa aaagtgatca cgagtttgta aagctatgta 47340 aaaatcatgc agagaaaagt tctccagaaa cgcaacaaat gattatcaaa cacatatacg 47400 aacaatatct tattccagta tctgaagtac tattaaaacc tataatgtcc atgggtgaca 47460 taattaca ta taacggatgt aaagacaatg aatggatgct agaacaactc tctaccctaa 47520 actttaacaa tctccgcaca tggaactcat gtagcatagg caatgtaacg cgtctgtttt 47580 atacattttt tagttatctg atgaaagata aactaaatat ataagtataa tcccattcta 47640 atactttaac ctgatgtatt acctgcatct tattagaata ttaacctaac taaaagacat 47700 aacatagttg ataaaaagcg gtaggatata aatattatgg ctgccaccgt tccgcgtttt 47760 gacgacgtgt acaaaaatgc acaaagaaga attctagatc aagaaacatt ttttagtaga 47820 ggtctaagta gaccgttaat gaaaaacaca tatctatttg ataattacgc gtatggatgg 47880 ataccagaaa ctgcaatttg gagtagtaga tacgcaaact tagatgcaag tgactattat 47940 cccatttcgt tgggattact taaaaagttc gagtttctca tgtctctata taaaggtcct 48000 attcccgtat atgaagaaaa agtaaatact gaattcattg ctaatggatc gttctctggt 48060 agatacgtat catatcttcg aaagttttct gcccttccaa caaacgagtt tattagtttt 48120 ttgttactga cttccattcc aatctataat atcttgttct ggtttaaaaa tactcagttt 48180 gatattacta aacacacatt attcagatac gtctatacag ataatgccaa acacctggcg 48240 ttggctaggt atatgcatca aacaggagac tataagcctt tgtttagtcg tctcaaagag 48300 aattatatat ttaccggtcc cgttccaata agtatcaaag atatagatca ccctaatctt 48360 agtagagcaa gaagtccatc cgattatgag acattagcta atattagtac tatattgtac 48420 tttaccaagt atgatccggt attaatgttt ttattgtttt acgtacctgg gtattcaatt 48480 actacaaaaa ttactccagc cgtagaatat ctaatggata aactgaatct aacaaagagc 48540 gacgtacaac tgttgtaaat tattttatgc ttcgtaaaat gtaggttttg aaccaaacat 48600 tctttcaaag aatgagatgc ataaaacttt attatccaat agattgacta tttcggacgt 48660 caatcgttta aagtaaactt cgtaaaatat tctttgatca ctgccgagtt taaaacttct 48720 atcgataatt gtttcatatg ttttaatatt tacaagtttt ttggtccatg gtacattagc 48780 cggacaaata tatgcaaaat aatatcgttc tccaagttct atagtttctg gattattttt 48840 attatattca gtaaccaaat acatattagg gttatctgcg gatttataat ttgagtgatg 48900 cattcgactc aacataaata attctagagg agacgatcta ctatcaaatt cggatcgtaa 48960 atctgtttct aaagaacgga gaatatctat acatacctga ttagaattca tccgtccttc 49020 agacaacatc tcagacagtc tggtcttgta tgtcttaatc atattcttat gaaacttgga 49080 aacatctctt ctagtttcac tagtaccttt attaattctc tcaggtacag attttgaat t 49140 cgacgatgct gagtatttca tcgttgtata tttcttcttc gattgcataa tcagattctt 49200 atataccgcc tcaaactcta ttttaaaatt attaaacaat actctattat taatcagtcg 49260 ttctaactct ttcgctattt ctatagactt atcgacatct tgactgtcta tctctgtaaa 49320 cacggagtcg gtatctccat acacgctacg aaaacgaaat ctgtaatcta taggcaacga 49380 tgttttcaca atcggattaa tatctctatc gtccatataa aatggattac ttaatggatt 49440 ggcaaaccgt aacataccgt tagataactc tgctccattt agtaccgatt ctagatacaa 49500 gatcattcta cgtcctatgg atgtgcaact cttagccgaa gcgtatgagt atagagcact 49560 atttctaaat cccatcagac catatactga gttggctact atcttgtacg tatattgcat 49620 ggaatcatag atggcctttt cagttgaact ggtagcctgt tttagcatct ttttatatct 49680 ggctctctct gccaaaaatg ttcttaatag tctaggaatg gttccttcta tcgatctatc 49740 gaaaattgct atttcagaga tgaggttcgg tagtctaggt tcacaatgaa ccgtaatata 49800 tctaggaggt ggatatttct gaagcaagag ctgattattt atttcttctt ccaatctatt 49860 ggtactaaca acgacaccga ctaatgtttc cggagataga tttccaaaga tacacacatt 49920 aggatacaga ctgttataat caaagattaa tacattatta ctaaacattt t ttgttttgg 49980 agcaaatacc ttaccgcctt cataaggaaa cttttgtttt gtttctgatc taactaagat 50040 agttttagtt tccaacaata gctttaacag tggacccttg atgactgtac tcgctctata 50100 ttcgaatacc atggattgag gaagcacata tgttgacgca cccgcgtctg tttttgtttc 50160 tactccataa tactcccaca aatactgaca caaacaagca tcatgaatac agtatctagc 50220 catatctaaa gctatgttta gattataatc cttatacatc tgagctaaat caacgtcatc 50280 ctttccgaaa gataatttat atgtatcatt aggtaaagta ggacatgata gtacgacttt 50340 aaatccattt tcccaaatat ctttacgaat tactttacat ataatatcct catcaacagt 50400 cacataatta cctgtggtta aaacctttgc aaatgcagcg gctttgcctt tcgcgtccgt 50460 agtatcgtca ccgatgaacg tcatttctct aactcctcta tttaatactt tacccatgca 50520 actgaacgcg ttcttggata tagaatccaa tttgtacgaa tccaattttt cagatttttg 50580 aatgaatgaa tatagatcga aaaatatagt tccattattg ttattaacgt gaaacgtagt 50640 attggccatg ccgcctactc ccttatgact agactgattt ctctcataaa tacagagatg 50700 tacagcttcc tttttgtccg gagatctaaa gataatcttc tctcctgtta ataactctag 50760 acgattagta atatatctca gatcaaagtt atgtccgtta aagg taacga cgtagtcgaa 50820 cgttagttcc aacaattgtt tagctattcg taacaaaact atttcagaac atagaactag 50880 ttctcgttcg taatccattt ccattagtga ctgtatcctc aaacatcctc tatcgacggc 50940 ttcttgtatt tcctgttccg ttaacatctc ttcattaatg agcgtaaaca ataatcgttt 51000 accacttaaa tcgatataac agtaacttgt atgcgagatt gggttaataa atacagaagg 51060 aaacttctta tcgaagtgac actctatatc tagaaataag tacgatcttg ggatatcgaa 51120 tctaggtatt tttttagcga aacagttacg tggatcgtca caatgataac atccattgtt 51180 aatctttgtc aaatattgct cgtccaacga gtaacatccg tctggagata tcccgttaga 51240 aatataaaac caactaatat tgagaaattc atccatggtg gcattttgta tgctgcgttt 51300 ctttggctct tctatcaacc acatatctgc gacggagcat tttctatctt taatatctag 51360 attataactt attgtctcgt caatgtctat agttctcatc tttcccaacg gcctcgcatt 51420 aaatggagga ggagacaatg actgatatat ttcgtccgta actacgtaat aaaagtaatg 51480 aggaaatcgt ataaatacgg tctcgccatt tcgacatctg gatttcagat ataaaaatct 51540 gttttcaccg tgactttcaa accaattaat gcaccgaaca tccatttata gaatttagaa 51600 atatattttc atttaaatga atcccaaaca ttgggga aga gccgtatgga ccattatttt 51660 tatagtactt tcgcaagcgg gtttagacgg caacatagaa gcgtgtaaac gaaaactata 51720 tactatagtc agcactcttc catgtcctgc atgtagacgg cacgcgacta tcgctataga 51780 ggacaataat gtcatgtcta gcgatgatct gaattatatt tattattttt tcatcagatt 51840 atttaacaat ttggcatctg atcccaaata cgcgatcgat gtgacaaagg ttaacccttt 51900 ataaacttaa cccattataa aacttatgat tagtcacgac tgaaataacc gcgtgattat 51960 tttttggtat aattctacac ggcatggttt ctgtaactat gaattcaacc cccgttacat 52020 tagtgaaatc tttaacaaac agcaagggtt cgtcaaagac ataaaactca ttgtttacaa 52080 tcgaaataga ccccctatca cacttaaaat aaaaaatatc cttatccttt accaccaaat 52140 aaaattctga ttggtcaatg tgaatgtatt cacttaacag ttccacaaat ttatttatta 52200 actccgaggc acatacatcg tcggtatttt ttatggcaaa ctttactctt ccagcatccg 52260 tttctaaaaa aatattaacg agttccattt atatcatcca atattattga aatgacgttg 52320 atggacagat gatacaaata agaaggtacg gtacctttgt ccaccatctc ctccaattca 52380 tgctctattt tgtcattaac tttaatgtat gaaaacagta cgccacatgc ttccatgaca 52440 gtgtgtaaca ctttggatac aaaatgtttg acattagtat aattgtccaa gactgtcaat 52500 ctataataga tagtagctat aatatattct atgatggtat tgaagaagat gacaatcttg 52560 gcatattgat catttaacac agacatggta tcaacagata gcttgaatga aagagaatca 52620 gtaattggaa taagcgtctt ctcgatagag tgtccgtata ccaacatgtc tgatattttg 52680 atgtattcca ttaaattatt tagttttttc tttttattct cgttaaacag catttctgtc 52740 aacggacccc aacatcgttg accgattaag ttttgattga tttttccgtg taaggcgtat 52800 ctagtcagat cgtatagcct atccaataat ccatcatctg tgcgtagatc acatcgtaca 52860 ctttttaatt ctctatagaa gagcgacaga cagcaatttc tttattctct acagatgtaa 52920 gatacttgaa gacattccta tgatgatgca gaattttgga taacacggta ttgatggtat 52980 ctgttaccat aattcctttg atggctgata gtgtcagagc acaagatttc caatctttgt 53040 tttgatatct atatcagaca gcatggtgcg tctgacaaca caaggattaa gacggaaaga 53100 tgaaatgatt ctctcaacat cttcaatgga taccttgcta ttttttctgg cattatctat 53160 atgtgcgaga atatcctcta gagaatcagt atcctttttg atgatagtgg atctcaatga 53220 catgggacgt ctaaaccttc ttattctatc accagattgc atggtgattt gtcttctttc 53280 ttttatcata atgtaatctc ta aattcatc ggcaaattgt ctatatctaa aatcataata 53340 tgagatgttt acctctacaa atatctgttc gtccaatgtt agagtatcta catcagtttt 53400 gtattccaaa ttaaacatgg caacggattt aattttatat tcctctatta agtcctcgtc 53460 gataataaca gaatgtagat aatcatttaa tccatcgtac atggttggaa gatgcttgtt 53520 gacaaaatct ttaattgtct tgatgaaggt gggactatat ctaacatctt gattaataaa 53580 atttataaca ttgtccatag gatactttgt aactagtttt atacacatct cttcatcggt 53640 aagtttagac agaatatcgt gaacaggtgg tatattatat tcatcagata tacgaagaac 53700 aatgtccaaa tctatattgt ttaatatatt atatagatgt agcgtagctc ctacaggaat 53760 atctttaact aagtcaatga tttcatcaac cgttagatct attttaaagt taatcatata 53820 ggcattgatt tttaaaaggt atgtagcctt gactacattc tcattaatta accattccaa 53880 gtcactgtgt gtaagaagat tatattctat cataagcttg actacatttg gtcccgatac 53940 cattaaagaa ttcttatgat ataaggaaac agattttagg tactcatcta ctctacaaga 54000 attttggaga gccttaacga tatcagtgac gtttattatt tcaggaggaa agaatctaac 54060 attgagaata tcggaattaa tagcttccag atacagtgat tttggcaata gtccgtgtaa 54120 tccataatcc agtaa cacga gctggtgctt gctagacacc ttttcaatgt ttaatttttt 54180 tgaaataagc tttgataaag ccttcctcgc aaattccgga tacatgaaca tgtcggcgac 54240 atgattaagt attgtttttt cattattttc tcaacaagtt ctcaataccc caatagatga 54300 tagaatatca cccaatgcgt ccatgttgtc tatttccaac aggtcgctat atccaccaat 54360 agaagttttt ccaaaaaaga ttctaggaac agttctacca ccagtaattt gttcaaaata 54420 gtcacgcaat tcattttcgg gtttaaattc tttaatatcg acaatttcat acgctcctct 54480 tttgaaacta aacttattta gaatatccag tgcatttcta caaaaaggac atgtatactt 54540 gacaaaaatt gtcactttgt tattggccaa cctttgttgt acaaattcct cggccatttt 54600 aatatttaag tgatataaaa ctatctcgac ttatttaact ctttagtcga gatatatgga 54660 cgcagatagc tatatgatag ccaactacag aaggcaaacg ctataaaaaa cataattacg 54720 acgagcatat ttataaatat ttttattcag cattacttga tatagtaata ttaggcacag 54780 tcaaacattc aaccactctc gatacattaa ctctctcatt ttctttaaca aattctacaa 54840 tatcttcgta aaaagattct tgaaactttt tagaatatct atcgactcta gatgaaatag 54900 cgttcgtcaa catactatgt tttgtataca taaaggcgcc cattttaaca gtttctagtg 54960 acaaaatgct agcgatccta ggatccttta gaatcacata gattgacgat tcgtctctct 55020 tagtaactct agtaaaataa tcatacaatc tagtacgcga aataatatta tccttgactt 55080 gaggagatct aaacaatcta gttttgagaa catcgataag ttcatcggga atgacataca 55140 tactatcttt aatagaactc ttttcatcca gttgaatgga ttcgtcctta accaactga t 55200 taatgagatc ttctatttta tcattttcca gatgatatgt atgtccatta aagttaaatt 55260 gtgtagcgct tctttttagt ctagcagcca atactttaac atcactaata tcgatataca 55320 aaggagatga tttatctatg gtattaagaa ttcgtttttc gacatctgtc aaaaccaatt 55380 cctttttgcc tgtatcatcc agttttccat cctttgtaaa gaaattattt tctactagac 55440 tattaataag actgataagg attcctccat aattgcacaa tccaaacttt ttaacaaaac 55500 tagactttac aagatctaca ggaatgcgta attcaggttt cttagcttgt gattttttct 55560 tttgtggaca ttttcttgtg accaactcat ctaccatttc attgatttta gcagtgaaat 55620 aagctttcaa tgcacgggca ctgatactat tgaaaacgag ttgatcttca aattccgcca 55680 tttaagttca ccaaacaact tttaaataca aatatatcaa tagtagtaga ataagaacta 55740 taaaaaaaat aataattaac caataccaac cccaacaacc ggtattatta gttgatgtga 55800 ctgttttctc atcacttaga acagatttaa caatttctat aaagtctgtc aaatcatctt 55860 ccggagaccc cataaataca ccaaatatag cggcgtacaa cttatccatt tatacattga 55920 atattggctt ttctttatcg ctatcttcat catattcatc atcaatatca acaagtccca 55980 gattacgagc cagatcttct tctacatttt cagtcattga tacacgttca c tatctccag 56040 agagtccgat aacgttagcc accacttctc tatcaatgat tagtttcttg agtgcgaatg 56100 taatttttgt ttccgttccg gatctataga agacgatagg tgtgataatt gccttggcca 56160 attgtctttc tcttttactg agtgattcta gttcaccttc tatagatctg agaatggatg 56220 attctccagt cgaaacatat tctaccatgg atccgtttaa tttgttgatg aagatggatt 56280 catccttaaa tgttttctct gtaatagttt ccaccgaaag actatgcaaa gaatttggaa 56340 tgcgttcctt gtgcttaatg tttccataga cggcttctag aagttgatac aacataggac 56400 tagccgcggt aacttttatt tttagaaagt atccatcgct tctatcttgt ttagatttat 56460 ttttataaag tttagtctct ccttccaaca taataaaagt ggaagtcatt tgactagata 56520 aactatcagt aagttttata gagatagacg aacaattagc gtattgagaa gcatttagtg 56580 taacgtattc gatacatttt gcattagatt tactaatcga ttttgcatac tctataacac 56640 ccgcacaagt ctgtagagaa tcgctagatg cagtaggtct tggtgaagtt tcaactctct 56700 tcttgattac cttactcatg attaaaccta aataattgta ctttgtaata taatgatata 56760 tattttcact ttatctcatt tgagaataaa aatgtttttg tttaaccact gcatgatgta 56820 cagatttcgg aatcgcaaac caccagtggt tttattttat cctt gtccaa tgtgaattga 56880 atgggagcgg atgcgggttt cgtacgtaga tagtacattc ccgtttttag accgagactc 56940 catccgtaaa aatgcatact cgttagtttg gaataactcg gatctgctat atggatattc 57000 atagattgac tttgatcgat gaaggctccc ctgtctgcag ccatttttat gatcgtcttt 57060 tgtggaattt cccaaatagt tttataaact cgcttaatat cttctggaag gtttgtattc 57120 tgaatggatc caccatctgc cataatccta ttcttgatct catcattcca taattttctc 57180 tcggttaaaa ctctaaggag atgcggatta actacttgaa attctccaga caatactctc 57240 cgagtgtaaa tattactggt atacggttcc accgactcat tatttcccaa aatttgagca 57300 gttgatgcag tcggcatagg tgccaccaat aaactatttc taagaccgta tgttctgatt 57360 ttatctttta gaggttccca attccaaaga tccgacggta caacattcca aagatcatat 57420 tgtagaatac cgttactggc gtacgatcct acatatgtat cgtatggtcc ttccttctca 57480 gctagttcac aactcgcctc taatgcaccg taataaatgg tttcgaagat cttcttattt 57540 agatcttgtg cttccaggct atcaaatgga taatttaaga gaataaacgc gtccgctaat 57600 ccttgaacac caataccgat aggtctatgt ctcttattag agatttcagc ttctggaata 57660 ggataataat taatatctat aattttattg agatttc tga caattacttt gaccacatcc 57720 ttcagtttga gaaaatcaaa tcgcccatct attacaaaca tgttcaaggc aacagatgcc 57780 agattacaaa cggctacctc attagcatcc gcatattgta ttatctcagt gcaaagatta 57840 ctacacttga tagttcctaa attttgttga ttactctttt tgttacacgc atccttataa 57900 agaatgaatg gagtaccagt ttcaatctga gattctataa tcgctttcca gacgactcga 57960 gcctttatta tagatttgta tctcctttct ctttcgtata gtgtatacaa tcgttcgaac 58020 tcgtctcccc aaacattgtc caatccagga cattcatccg gacacatcaa cgaccactct 58080 ccgtcatcct tcactcgttt cataaagaga tcaggaatcc aaagagctat aaatagatct 58140 ctggttctat gttcctcgtt tcctgtattc tttttaagat cgaggaacgc cataatatca 58200 gaatgccacg gttccaagta tatggccata actccaggcc gtttgtttcc tccctgatct 58260 atgtatctag cggtgttatt ataaactctc aacattggaa taataccgtt tgatatacca 58320 ttggtaccgg agatatagct tccactggca cgaatattac taattgatag acctattccc 58380 cctgccattt tagagattaa tgcgcatcgt tttaacgtgt catagatacc ctctatgcta 58440 tcatcgatca tgttaagtag aaaacagcta gacatttggt gacgactagt tcccgcatta 58500 aataaggtag gagaagcgtg cgtaaaccat ttttcagaaa gtagattgta cgtctcaata 58560 gctgagtcta tatcccattg atgaattcct actgcgacac gcattaacat gtgctgaggt 58620 ctttcaacga tcttgttgtt tattttcaac aagtaggatt tttccaaagt tttaaaacca 58680 aaatagttgt atgaaaagtc tcgttcgtaa ataataaccg agttgagttt atccttatat 58740 ttgttaacta tatccatggt gatacttgaa ataatcggag aatgtttccc atttttagga 58800 ttaacatagt tgaataaatc ctccatcact tcactaaata gtttttttgt ttccttgtgt 58860 agatttgata cggctattct ggcggctaga atggcataat ccggatgttg tgtagtacaa 58920 gtggctgcta tttcggctgc cagagtgtcc aattctaccg ttgttactcc attatatatt 58980 ccttgaataa ccttcatagc tattttaata ggatctatat gatccgtgtt taagccataa 59040 cataattttc taatacgaga cgtgatttta tcaaacatga cattttcctt gtatccattt 59100 cgtttaatga caaacatttt tgttggtgta ataaaaaaaa ttatttaact tttcattaat 59160 agggatttga cgtatgtagc gtacaaaatt atcgttcctg gtatatagat aaagagtcct 59220 atatatttga aaatcgttac ggctcgatta aactttaatg attgcatagt gaatatatca 59280 ttaggattta actccttgac tatcatggcg gcgccagaaa ttaccatcaa aagcattaat 59340 acagttatgc cgatcgcagt ta gaacggtt atagcatcca ccatttatat ctaaaaatta 59400 gatcaaagaa tatgtgacaa agtcctagtt gtatactgag aattgacgaa acaatgtttc 59460 ttacatattt tttttttatt agtaaccgac ttaatagtag gaactggaaa actagacttg 59520 attattctat aagtatagat acccttccaa ataatattct ctttgataaa agttccagaa 59580 aatgtagaat tttttaaaaa gttatctttt gctattacca agattgtgtt tagacgctta 59640 ttattaatat gagtgatgaa atccacaccg cctctagata tcgcttttat ttccacatta 59700 gatggtaaat ccaatagtga aactatcttt ttaggaatgt atggactcgc gtttagagga 59760 gtgaacgtct taggcgtcgg aaaggggccg gccttttttt ctagacacta aataaatagt 59820 aagattaaat taattataaa attatgtata taatattaat tataaaatta tgtatatgat 59880 tactaactt tagttagata aattataataat acataaattta 60 attatatatta atattataaa 59940 cctatta atattataaaa 59940 ttaatagtata atatata <210> 13 <211> 63035 <212> DNA <213> Artificial Sequence <220> <223> sMVA fragment 2 <400> 13 ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60 attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120 aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180 gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccataa 240 aaatgttttt gtttaaccac tgcatgatgt acagatttcg gaatcgcaaa ccaccagtgg 300 ttttatttta tccttgtcca atgtgaattg aatgggagcg gatgcgggtt tcgtacgtag 360 atagtacatt cccgttttta gaccgagact ccatccgtaa aaatgcatac tcgttagttt 420 ggaataactc ggatctgcta tatggatatt catagattga ctttgatcga tgaaggctcc 480 cctgtctgca gccattttta tgatcgtctt ttgtggaatt tcccaaatag ttttataaac 540 tcgcttaata tcttctggaa ggtttgtatt ctgaatggat ccaccatctg ccataatcct 600 attcttgatc tcatcattcc ataattttct ctcggttaaa actctaagga gatgcggatt 660 aactacttga aattctccag acaatactct ccgagtgtaa atattactgg tatacggttc 720 caccgactca ttatttccca aaatttgagc agttgatgca gtcggcatag gtgccaccaa 780 taaactattt ctaagaccgt atgttctgat tttatctttt agaggttccc aattccaaag 840 atccgacggt a caacattcc aaagatcata ttgtagaata ccgttactgg cgtacgatcc 900 tacatatgta tcgtatggtc cttccttctc agctagttca caactcgcct ctaatgcacc 960 gtaataaatg gtttcgaaga tcttcttatt tagatcttgt gcttccaggc tatcaaatgg 1020 ataatttaag agaataaacg cgtccgctaa tccttgaaca ccaataccga taggtctatg 1080 tctcttatta gagatttcag cttctggaat aggataataa ttaatatcta taattttatt 1140 gagatttctg acaattactt tgaccacatc cttcagtttg agaaaatcaa atcgcccatc 1200 tattacaaac atgttcaagg caacagatgc cagattacaa acggctacct cattagcatc 1260 cgcatattgt attatctcag tgcaaagatt actacacttg atagttccta aattttgttg 1320 attactcttt ttgttacacg catccttata aagaatgaat ggagtaccag tttcaatctg 1380 agattctata atcgctttcc agacgactcg agcctttatt atagatttgt atctcctttc 1440 tctttcgtat agtgtataca atcgttcgaa ctcgtctccc caaacattgt ccaatccagg 1500 acattcatcc ggacacatca acgaccactc tccgtcatcc ttcactcgtt tcataaagag 1560 atcaggaatc caaagagcta taaatagatc tctggttcta tgttcctcgt ttcctgtatt 1620 ctttttaaga tcgaggaacg ccataatatc agaatgccac ggttccaagt atatggccat 1680 aactccaggc cgtttgttt c ctccctgatc tatgtatcta gcggtgttat tataaactct 1740 caacattgga ataataccgt ttgatatacc attggtaccg gagatatagc ttccactggc 1800 acgaatatta ctaattgata gacctattcc ccctgccatt ttagagatta atgcgcatcg 1860 ttttaacgtg tcatagatac cctctatgct atcatcgatc atgttaagta gaaaacagct 1920 agacatttgg tgacgactag ttcccgcatt aaataaggta ggagaagcgt gcgtaaacca 1980 tttttcagaa agtagattgt acgtctcaat agctgagtct atatcccatt gatgaattcc 2040 tactgcgaca cgcattaaca tgtgctgagg tctttcaacg atcttgttgt ttattttcaa 2100 caagtaggat ttttccaaag ttttaaaacc aaaatagttg tatgaaaagt ctcgttcgta 2160 aataataacc gagttgagtt tatccttata tttgttaact atatccatgg tgatacttga 2220 aataatcgga gaatgtttcc catttttagg attaacatag ttgaataaat cctccatcac 2280 ttcactaaat agtttttttg tttccttgtg tagatttgat acggctattc tggcggctag 2340 aatggcataa tccggatgtt gtgtagtaca agtggctgct atttcggctg ccagagtgtc 2400 caattctacc gttgttactc cattatatat tccttgaata accttcatag ctattttaat 2460 aggatctata tgatccgtgt ttaagccata acataatttt ctaatacgag acgtgatttt 2520 atcaaacatg acattttcct tgta tccatt tcgtttaatg acaaacattt ttgttggtgt 2580 aataaaaaaa attatttaac ttttcattaa tagggatttg acgtatgtag cgtacaaaat 2640 tatcgttcct ggtatataga taaagagtcc tatatatttg aaaatcgtta cggctcgatt 2700 aaactttaat gattgcatag tgaatatatc attaggattt aactccttga ctatcatggc 2760 ggcgccagaa attaccatca aaagcattaa tacagttatg ccgatcgcag ttagaacggt 2820 tatagcatcc accatttata tctaaaaatt agatcaaaga atatgtgaca aagtcctagt 2880 tgtatactga gaattgacga aacaatgttt cttacatatt ttttttttat tagtaaccga 2940 cttaatagta ggaactggaa aactagactt gattattcta taagtataga tacccttcca 3000 aataatattc tctttgataa aagttccaga aaatgtagaa ttttttaaaa agttatcttt 3060 tgctattacc aagattgtgt ttagacgctt attattaata tgagtgatga aatccacacc 3120 gcctctagat atcgctttta tttccacatt agatggtaaa tccaatagtg aaactatctt 3180 tttaggaatg tatggactcg cgtttagagg agtgaacgtc ttaggcgtcg gaaaggatga 3240 ttcatcaaac gaataaacaa tttcacaaat ggatgttaat gtattagtag gaaatttttt 3300 gacgctagtg gaattgaaga ttctaatgga tgatgttcta cctatttcat ccgataacat 3360 gttaatttcc gacaccaacg gttttaatat ttcgatgata tacggtagtc tctctttcgg 3420 acttatatag cttattccac aatacgagtc attatatact ccaaaaaaca aaataactag 3480 tataaaatct gtatcgaatg ggaaaaacga aattatcgac ataggtatag aatctggaac 3540 attgaacgta ttaatactta attctttttc tgtggtaagt accgataggt tattgacatt 3600 gtatggtttt aaatattcta taacttgaga cttgatagat attagtgatg aattgaaaat 3660 tatttttatc accacgtgtg tttcaggatc atcgtcgacg cccgtcaacc aaccgaatgg 3720 agtaaaataa atatcattaa tatatgctct agatattagt atttttatca atcctttgat 3780 tatcatcttc tcgtaggcga atgattccat gatcaagagt gatttaagaa catcctccgg 3840 agtattaatg ggcttagtaa acagtccatc gttgcaataa taaaagttat ccaagttaaa 3900 ggatattatg cattcgttta aagatatcac ctcatctgac ggagacaatt ttttggtagg 3960 ttttagagac tttgaagcta cttgtttaac aaagttattc atcgtcgttt actattctat 4020 ttaattttgt agttaattta tcacatatca cattaattga ctttttggtc catttttcca 4080 tacgtttata ttcttttaat cctgcgttat ccgtttccgt tatatccagg gatagatctt 4140 gcaagttaaa tagaatgctc ttaaataatg tcattttctt atccgctaaa aatttaaaga 4200 atgtataaac ctttttcaga gatttgaaac tctta ggtgg tgtcctagta cacaatatca 4260 taaacaaact aataaacatt ccacattcag attccaacag ctgattaact tctacattaa 4320 tacagcctat tttcgctcca aatgtacatt cgaaaaatct gaataaaaca tcgatgtcac 4380 aatttgtatt atccaataca gaatgtttgt gattcgtgtt aaaaccatcg gagaaggaat 4440 aaaaataaaa attattatag tggtggaatt cagttggaat attgcctccg gagtcataaa 4500 aggatactaa acattgtttt ttatcataaa ttacacattt ccaatgagac aaataacaaa 4560 atccaaacat tacaaatcta gaggtagaac ttttaatttt gtctttaagt atatacgata 4620 agatatgttt attcataaac gcgtcaaatt tttcatgaat cgctaaggag tttaagaatc 4680 tcatgtcaaa ttgtcctata taatccactt cggatccata agcaaactga gagactaagt 4740 tcttaatact tcgattgctc atccaggctc ctctctcagg ctctattttc atcttgacga 4800 cctttggatt ttcaccagta tgtattcctt tacgtgataa atcatcgatt ttcaaatcca 4860 tttgtgagaa gtctatcgcc ttagatactt tttcccgtag tcgaggttta aagaaatacg 4920 ctaacggtat actagtaggt aactcaaaga catcatatat agaatggtaa cgcgtcttta 4980 actcgtcggt taactctttc ttttgatcga gttcgtcgct actattgggt ctgctcaggt 5040 gccccgactc tactagttcc aacatcatac cgataggaat acaagacact ttgccggcgg 5100 ttgtagattt atcatatttc tccactacat atccgttaca atttgttaaa aatttagata 5160 catctatatt gctacataat ccagctagtg aatatatatg acataataaa ttggtaaatc 5220 ctagttctgg tattttacta attactaaat ctgtatatct ttccatttat catggaaaag 5280 aatttaccag atatcttctt ttttccaaac tgcgttaatg tattctctta caaatattca 5340 caagatgaat tcagtaatat gagtaaaacg gaacgtgata gtttctcatt ggcggtgttt 5400 ccagttataa aacatagatg gcataacgca cacgttgtaa aacataaagg aatatacaaa 5460 gttagtacag aagcacgtgg aaaaaaagta tctcctccat cactaggaaa acccgcacac 5520 ataaacctaa ccgcgaagca atatatatac agtgaacaca caataagctt tgaatgttat 5580 agttttctaa aatgtataac aaatacagaa atcaattcgt tcgatgagta tatattaaga 5640 ggactattag aagctggtaa tagtttacag atattttcca attccgtagg taaacgaaca 5700 gatactatag gtgtactagg gaataagtat ccatttagca aaattccatt ggcctcatta 5760 actcctaaag cacaacgaga gatattttca gcgtggattt ctcatagacc tgtagtttta 5820 actggaggaa ctggagtggg taagacgtca caggtaccca agttattgct ttggtttaat 5880 tatttatttg gtggattctc tactctagat aaaatcactg actttc acga aagaccagtc 5940 attctatctc ttcctaggat agctttagtt agattgcata gcaataccat tttaaaatca 6000 ttgggattta aggtactaga tggatctcct atttctttac ggtacggatc tataccggaa 6060 gaattaataa acaaacaacc aaaaaaatat ggaattgtat tttctaccca taagttatct 6120 ctaacaaaac tatttagtta tggcactctt attatagacg aagttcatga gcatgatcaa 6180 ataggagata ttattatagc agtagcgaga aagcatcata cgaaaataga ttctatgttt 6240 ttaatgactg ccacgttaga ggatgacagg gaacggctaa aagtattttt acctaatccc 6300 gcatttatac atattcctgg agatacactg tttaaaatta gcgaggtatt tattcataat 6360 aagataaatc catcttccag aatggcatac atagaagaag aaaagagaaa tttagttact 6420 gctatacaga tgtatactcc tcctgatgga tcatccggta tagtctttgt ggcatccgtt 6480 gcacagtgtc acgaatataa atcatattta gaaaaaagat taccgtatga tatgtatatt 6540 attcatggta aggtcttaga tatagacgaa atattagaaa aagtgtattc atcacctaat 6600 gtatcgataa ttatttctac tccttatttg gaatccagcg ttactatacg caatgttaca 6660 cacatttatg atatgggtag agtttttgtc cccgctcctt ttggaggatc gcaagaattt 6720 atttctaaat ctatgagaga tcaacgaaaa ggaagagtag gaagagttaa t cctgggaca 6780 tacgtatatt tctatgatct gtcttatatg aagtctatac agcgaataga ttcagaattt 6840 ctacataatt atatattgta cgctaataag tttaatctaa cactccccga agatttgttt 6900 ataatcccta caaatttgga tattctatgg cgtacaaagg aatatataga ctcgttcgat 6960 attagtacag aaacatggaa taaattatta tccaattatt atatgaagat gatagagtat 7020 gctaaacttt atgtactaag tcctattctc gctgaggagt tggataattt tgagaggacg 7080 ggagaattaa ctagtattgt acaagaagcc attttatctc taaatttacg aattaagatt 7140 ttaaatttta aacataaaga tgatgatacg tatatacact tttgtaaaat attattcggt 7200 gtctataacg gaacaaacgc tactatatat tatcatagac ctctaacggg atatatgaat 7260 atgatttcag atactatatt tgttcctgta gataataact aaaaatcaaa ctctaatgac 7320 cacatctttt tttagagatg aaaaattttc cacatctcct tttgtagaca cgactaaaca 7380 ttttgcagaa aaaagtttat tagtgtttag ataatcgtat acttcatcag tgtagatagt 7440 aaatgtgaac agataaaagg tattcttgct caatagattg gtaaattcca tagaatatat 7500 taatcctttc ttcttgagat cccacatcat ttcaaccaga gacgttttat ccaatgattt 7560 acctcgtact ataccacata caaaactaga ttttgcagtg acgtcgtatc tggtatt cct 7620 accaaacaaa attttacttt tagttctttt agaaaattct aaggtagaat ctctatttgc 7680 caatatgtca tctatggaat taccactagc aaaaaatgat agaaatatat attgatacat 7740 cgcagctggt tttgatctac tatactttaa aaacgaatca gattccataa ttgcctgtat 7800 atcatcagct gaaaaactat gttttacacg tattccttcg gcatttcttt ttaatgatat 7860 atcttgttta gacaatgata aagttatcat gtccatgaga gacgcgtctc cgtatcgtat 7920 aaatatttca ttagatgtta gacgcttcat taggggtata cttctataag gtttcttaat 7980 cagtccatca ttggttgcgt caagaactac tatcggatgt tgttgggtat ctctagtgtt 8040 acacatggcc ttactaaagt ttgggtaaat aactatgata tctctattaa ttatagatgc 8100 atatatttca tttgtcaagg atattagtat cgacttgcta tcgtcattaa tacgtgtaat 8160 gtaatcatat aaatcatgcg atagccaagg aaaatttaaa tagatgttca tcatataatc 8220 gtcgctataa ttcatattaa tacgttgaca ttgactaatt tgtaatatag cctcgccacg 8280 aagaaagctc tcgtattcag tttcatcgat aaaggatacc gttaaatata actggttgcc 8340 gatagtctca tagtctatta agtggtaagt ttcgtacaaa tacagaatcc ctaaaatatt 8400 atctaatgtt ggattaatct ttaccataac tgtataaaat ggagacggag tcataactat 84 60 tttaccgttt gtacttactg gaatagacga aggaataatc tccggacatg ctggtaaaga 8520 cccaaatgtc tgtttgaaga aatccaatgt tccaggtcct aatctcttaa caaaaattac 8580 gatattcgat cccgatatcc tttgcattct atttaccagc atatcacgaa ctatattaag 8640 attatctatc atgtctattc tcccaccgtt atataaatcg cctccgctaa gaaacgttag 8700 tatatccata caatggaata cttcatttct aaaatagtat tcgttttcta attctttaat 8760 gtgaaatcgt atactagaaa gggaaaaatt atctttgagt tttccgttag aaaagaacca 8820 cgaaactaat gttctgattg cgtccgattc cgttgctgaa ttaatggatt tacaccaaaa 8880 actcatataa cttctagatg tagaagcatt cgctaaaaaa ttagtagaat caaaggatat 8940 aagtagatgt tccaacaagt gagcaattcc caagatttca tctatatcat tctcgaatcc 9000 gaaattagaa attcccaagt agatatcctt tttcatccga tcgttgatga aaatacgaac 9060 tttattcggt aagacaatca tttactaagg agtaaaatag gaagtaatgt tcgtatgtcg 9120 ttatcatcgt ataaattaaa ggtgtgtttt ttaccattaa gtgacattat aattttacca 9180 atattggaat tataatatag gtgtatttgc gcactcgcga cggttgatgc atcggtaaat 9240 atagctgtat ctaatgttct agtcggtatt tcatcatttc gctgtctaat aatagcgttt 9300 tct ctatctg tttccattac agctgcctga agtttattgg tcggataata tgtaaaataa 9360 taagaaatac atacgaataa caaaaataaa ataagatata ataaagatgc catttagaga 9420 tctaattttg tttaacttgt ccaaattcct acttacagaa gatgaggaat cgttggagat 9480 agtgtcttcc ttatgtagag gatttgaaat atcttatgat gacttgataa cttactttcc 9540 agataggaaa taccataaat atatttctaa agtatttgaa catgtagatt tatcggagga 9600 attaagtatg gaattccatg atacaactct gagagattta gtctatctta gattgtacaa 9660 gtattccaag tgtatacggc cgtgttataa attaggagat aatctaaaag gcatagttgt 9720 tataaaggac aggaatattt atattagaga agcaaatgat gacttgatag aatatctcct 9780 caaggaatac actcctcaga tttatacata ttctaatgag cgcgtcccca taactggttc 9840 aaaattaatt ctttgtggat tttctcaagt tacatttatg gcgtatacaa cgtcgcatat 9900 aacaacaaat aaaaaggtag atgttctcgt ttccaaaaaa tgtatagatg aactagtcga 9960 tccaataaat tatcaaatac ttcaaaattt atttgataaa ggaagcggaa caataaacaa 10020 aatactcagg aagatatttt attcggtaac cggtggccaa actccataat ttgctttttc 10080 tatttcggat tttagaattt ccaaattcac cagcgattta tcggttttgg tgaaatccaa 10140 ggattt atta atgtccacaa atgccatttg ttttgtctgt ggattgtatt tgaaaatgga 10200 aacgatgtag ttagatagat gcgctgcaaa gtttcctatt agggttccgc gctttacgtc 10260 acccagcata cttgaatcac catcctttaa aaaaaatgat aagatatcaa catggagtat 10320 atcatactcg gattttaatt cttctactgc atcactgaca ttttcacaaa tactacaata 10380 cggtttaccg aaaataatca gtacgttctt catttatggg tatcaaaaac ttaaaatcgt 10440 tactgctgga aaataaatca ctgacgatat tagatgataa tttatacaaa gtatacaatg 10500 gaatatttgt ggatacaatg agtatttata tagccgtcgc caattgtgtc agaaacttag 10560 aagagttaac tacggtattc ataaaatacg taaacggatg ggtaaaaaag ggagggcatg 10620 taaccctttt tatcgataga ggaagtataa aaattaaaca agacgttaga gacaagagac 10680 gtaaatattc taaattaacc aaggacagaa aaatgctaga attagaaaag tgtacatccg 10740 aaatacaaaa tgttaccgga tttatggaag aagaaataaa ggcagaaatg caattaaaaa 10800 tcgataaact cacatttcaa atatatttat ctgattctga taacataaaa atatcattga 10860 atgagatact aacacatttc aacaataatg agaatgttac attattttat tgtgatgaac 10920 gagacgcaga attcgttatg tgtctcgagg ctaaaacaca tttctctacc acaggagaat 1098 0 ggccgttgat aataagtacc gatcaggata ctatgctatt tgcatctact gataatcatc 11040 ctaagatgat aaaaaactta actcaactgt ttaaatttgt tccctcggca gaggataact 11100 atttagcaaa attaacggcg ttagtgaatg gatgtgattt ctttcctgga ctctatgggg 11160 catctataac acccaccaac ttaaacaaaa tacaattgtt tagtgatttt acaatcgata 11220 atatagtcac tagtttggca attaaaaatt attatagaaa gactaactct accgtagacg 11280 tgcgtaatat tgttacgttt ataaacgatt acgctaattt agacgatgtc tactcgtatg 11340 ttcctccttg tcaatgcact gttcaagaat ttatattttc cgcattagat gaaaaatgga 11400 acaattttaa atcatcttat ttagagaccg ttccgttacc ctgccaatta atgtatgcat 11460 tagaaccacg caaggagatt gatgtttcag aagttaaaac tttatcatct tatatagatt 11520 tcgaaaatac taaatcagat atcgatgtta taaaatctat atcttcgatc ttcggatatt 11580 ctaacgaaaa ctgtaacact atagtgttcg gcatctataa ggataattta ctactgagta 11640 taaatagttc attttacttt aacgatagtc tgttaataac caatactaaa agtgataata 11700 taataaatat aggttactag attaaaaatg gtgttccaac tcgtgtgctc tacgtgcggc 11760 aaagatattt ctcacgaacg atataaattg attatacgaa aaaaatcatt aaaggat gta 11820 ctcgtcagtg taaagaacga atgttgtagg ttaaaattat ctacacaaat agaacctcaa 11880 cgtaacttaa cagtgcaacc tctattggat ataaactaat atggatccgg ttaattttat 11940 caagacatat gcgcctagag gttctattat ttttattaat tataccatgt cattaacaag 12000 tcatttgaat ccatcgatag aaaaacatgt gggtatttat tatggtacgt tattatcgga 12060 acacttggta gttgaatcta cctatagaaa aggagttcga atagtcccat tggatagttt 12120 ttttgaagga tatcttagtg caaaagtata catgttagag aatattcaag ttatgaaaat 12180 agcagctgat acgtcattaa ctttattggg tattccgtat ggatttggtc ataatagaat 12240 gtattgtttt aaattggtag ctgaatgtta taaaaatgcc ggtattgata catcgtctaa 12300 acgaatatta ggtaaagata tttttctgag ccaaaacttc acagatgata atagatggat 12360 aaagatatat gattctaata atttaacatt ttggcaaatt gattacctta aagggtgagt 12420 taatatgcat aactactcct ccgttgtttt ttccctcgtt ctttttctta acgttgtttg 12480 ccatcactct cataatgtaa agatattcta aaatggtaaa cttttgcata tcggacgcag 12540 aaattggtat aaatgttgta attgtattat ttcccgtcaa tggactagtc acagctccat 12600 cagttttata tcctttagag tatttctcac tcgtgtctaa cattctagag cattccatga 12660 tctgtttatc gttgatattg gccggaaaga tagatttttt attttttatt atattactat 12720 tggcaattgt agatataact tctggtaaat atttttctac cttttcaatc tcttctattt 12780 tcaagccggc tatatattct gctatattgt tgctagtatc aatacctttt ctggctaaga 12840 agtcatatgt ggtattcact atatcagttt taactggtag ttccattagc ctttccactt 12900 ctgcagaata atcagaaatt ggttctttac cagaaaatcc agctactata ataggctcac 12960 cgatgatcat tggcaaaatc ctatattgta ccagattaat gagagcatat ttcatttcca 13020 ataattctgc tagttcttga gacattgatt tatttgatga atctagttgg ttctctagat 13080 actctaccat ttctgccgca tacaataact tgttagataa aatcagggtt atcaaagtgt 13140 ttagcgtggc tagaatagtg ggcttgcatg tattaaagaa tgcggtagta tgagtaaacc 13200 gttttaacga attatatagt ctccagaaat ctgtggcgtt acatacatga gccgaatgac 13260 atcgaagatt gtccaatatt tttaatagct gctctttgtc cattatttct atatttgact 13320 cgcaacaatt gtagatacca ttaatcactg attccttttt cgatgccgga caatagcaca 13380 attgtttagc tttggactct atgtattcag aattaataga tatatctctc aatacagatt 13440 gcactataca ttttgaaact atgtcaaaaa ttgtagaacg ac gctgttct gcagccattt 13500 aactttaaat aatttacaaa aatttaaaat gagcatccgt ataaaaatcg ataaactgcg 13560 ccaaattgtg gcatattttt cagagttcag tgaagaagta tctataaatg tagactcgac 13620 gggatgagtta at gccattaatg tagactcgac 13620 gggatgagtta at acctctcagt gcatcagtgt tctaccgcgg agccgaaaac attgtgttta atcttcctgt 13740 gtccaaggta aaatcgtgtt tgtgtagttt tcacaatgat gccatcatag atatagaacc 13800 tgatctggaa aataatctag taaaactttc tagttatcat gtagtaagtg tcgattgtaa 13860 caaggaactg atgcctatta ggacagatac tactatttgt ctaagtatag atcaaaagaa 13920 atcttacgtg tttaattttc acaagtatga agaaaaatgt tgtggtagaa ccgtcattca 13980 tttagaatgg ttgttgggct ttatcaagtg tattagtcag catcagcatt tggctattat 14040 gtttaaagat gacaatatta ttatgaagac tcctggtaat actgatgcgt tttccaggga 14100 atattctatg actgaatgtt ctcaagaact acaaaagttt tctttcaaaa tagctatctc 14160 gtctctcaac aaactacgag gattcaaaaa gagagtcaat gtttttgaaa ctagaatcgt 14220 aatggataat gacgataaca ttctaggaat gttgttttcg gatagagttc aatcctttaa 14280 gatcaacatc tttatgacgt ttttagatta atactttcaa tgagataaat atgggtggca 14340 gagtaagtgt tgagctccct aaacgggatc cgcctccggg agtacccact gatgagatgt 14400 tattaaacgt ggataaaatg catgacgtga tagctcccgc taagctttta gaatatgtgc 14460 atataggacc actagcaaaa gataaagagg ataaagtaaa gaaaagatat ccagagttt a 14520 gattagtcaa cacaggaccc ggtggtcttt cggcattgtt aagacaatcg tataatggaa 14580 ccgcacccaa ttgctgtcgc acttttaatc gtactcatta ttggaaaaag gatggaaaga 14640 tatcagataa gtatgaagag ggtgcagtat tagaatcgtg ttggccagac gttcacgaca 14700 ctggaaaatg cgatgttgat ttattcgact ggtgtcaggg ggatacgttc gatagaaaca 14760 tatgccatca gtggatcggt tcagccttta ataggagtga tagaactgta gagggtcaac 14820 aatcgttaat aaatctgtat aataagatgc aaacattatg tagtaaagat gctagtgtac 14880 caatatgtga atcatttttg catcatttac gcgcacacaa tacagaagat agcaaagaga 14940 tgatcgatta tattctaaga caacagtctg cggactttaa acagaaatat atgagatgta 15000 gttatcccac tagagataag ttagaagagt cattaaaata tgcggaacct cgagaatgtt 15060 gggatccaga gtgttcgaat gccaatgtta atttcttact aacacgtaat tataataatt 15120 taggactttg caatattgta cgatgtaata ctagcgtgaa caacttacag atggataaaa 15180 cttcctcatt aagattgtca tgtggattaa gcaatagtga tagattttct actgttcccg 15240 tcaatagagc aaaagtagtt caacataata ttaaacattc gttcgaccta aaattgcatt 15300 tgatcagttt attatctctc ttggtaatat ggatactaat tgtagctatt t aaatgggtg 15360 ccgcggcaag catacagacg acggtgaata cactcagcga acgtatctcg tctaaattag 15420 aacaagaagc gaacgctagt gctcaaacaa aatgtgatat agaaatcgga aatttttata 15480 tccgacaaaa ccatggatgt aacctcactg ttaaaaatat gtgctctgcg gacgcggatg 15540 ctcagttgga tgctgtgtta tcagccgcta cagaaacata tagtggatta acaccggaac 15600 aaaaagcata cgtaccagct atgtttactg ctgcgttaaa cattcagacg agtgtaaaca 15660 ctgttgttag agattttgaa aattatgtga aacagacttg taattctagc gcggtcgtcg 15720 ataacaaatt aaagatacaa aacgtaatca tagatgaatg ttacggagcc ccaggatctc 15780 caacaaattt ggaatttatt aatacaggat ctagcaaagg aaattgtgcc attaaagcgt 15840 tgatgcaatt gacgactaag gccactactc aaatagcacc tagacaagtt gctggtacag 15900 gagttcagtt ttatatgatt gttatcggtg ttataatatt ggcagcgttg tttatgtact 15960 atgccaagcg tatgttgttc acatccacca atgataaaat caaacttatt ttagccaata 16020 aggaaaacgt ccattggact acttacatgg acacattctt tagaacttct ccgatggtta 16080 ttgctaccac ggatatgcaa aactgaaaat atattgataa tattttaata gattaacatg 16140 gaagttatcg ctgatcgtct agacgatata gtgaaacaaa atat agcgga tgaaaaattt 16200 gtagattttg ttatacacgg tctagagcat caatgtcctg ctatacttcg accattaatt 16260 aggttgttta ttgatatact attatttgtt atagtaattt atatttttac ggtacgtcta 16320 gtaagtagaa attatcaaat gttgttggcg ttggtggcgc tagtcatcac attaactatt 16380 ttttattact ttatactata atagtactag actgacttct aacaaacatc tcacctgcca 16440 taaataaatg cttgatatta aagtcttcta tttctaacac tattccatct gtggaaaata 16500 atactctgac attatcgcta attgacacat cggtgagtga tatgcctata aagtaataat 16560 cttctttggg cacatatacc agtgtaccag gttctaacaa cctatttact ggtgctcctg 16620 tagcatactt tttctttacc ttgagaatat ccatcgtttg cttggtcaat agcgatatgt 16680 gattttttat caaccactca aaaaagtaat tggagtgttc atatcctcta cgggctattg 16740 tctcatggcc gtgtatgaaa tttaagtaac acgactgtgg tagatttgtt ctatagagcc 16800 ggttgccgca aatagataga actaccaata tgtctgtaca aatgttaaac attaattgat 16860 taacagaaaa aacaatgttc gttctgggaa tagaaaccag atcaaaacaa aattcgttag 16920 aatatatgcc acgtttatac atggaatata aaataactac agtttgaaaa ataacagtat 16980 catttaaaca tttaacttgc ggggttaatt tcacaac ttt actgttttta aactgttcaa 17040 aatatagcat cgatccatga gaaatacgtt tagccgcctt taatagagga aatcccaccg 17100 cctttctgga tctcaccaac gacgatagtt ctgaccagca acttatttct tcatcatcca 17160 cctgttttaa catataatag gcaggagata gatatccgtc attgcaatat tccttttcgt 17220 aggcacacaa tctaatattg ataaaatctc cattctcttc tctgcattta ttatcttgtt 17280 tcggtggctg attaggctgt agtcttggtt taggctttgg tatatcgttg ttgaatctat 17340 tttggtcatt aaatctttca tttcttcctg gtatatttct atcacctcgt ttggttggat 17400 ttttgtctat attatcgttt gtaacatcgg tacgggtatt catttatcac aaaaaaaact 17460 tctctaaatg agtctactgc tagaaaacct catcgaagaa gataccatat tttttgcagg 17520 aagtatatct gagtatgatg atttacaaat ggttattgcc ggcgcaaaat ccaaatttcc 17580 aagatctatg ctttctattt ttaatatagt acctagaacg atgtcaaaat atgagttgga 17640 gttgattcat aacgagaata tcacaggggc aatgtttacc acaatgtata atataagaaa 17700 caatttgggt ctaggagatg ataaactaac tattgaagcc attgaaaact atttcttgga 17760 tcctaacaat gaggttatgc ctcttatcat taataatacg gatatgactg ccgtcattcc 17820 taaaaaaagt ggtaggagaa agaataagaa catggttatt ttccgtcaag gatcatcacc 17880 tatcttgtgt attttcgaaa ctcgtaaaaa gattaatatt tataaagaaa atatggaatc 17940 cgcgtcgact gagtatacac ctatcggaga caacaaggct ttgatatcta aatatgcggg 18000 aattaatgtc ctgaatgtgt attctccttc cacatccatg agattgaatg ccatttacgg 18060 attcaccaat aaaaataaac tagagaaact tagtactaat aaggaactag aatcgtatag 18120 ttctagccct cttcaagaac ccattaggtt aaatgatttt ctgggactat tggaatgtgt 18180 taaaaagaat attcctctaa cagatattcc gacaaaggat tgattactat aaatggagaa 18240 tgttcctaat gtatacttta atcctgtgtt tatagagccc acgtttaaac attctttatt 18300 aagtgtttat aaacacagat taatagtttt atttgaagta ttcattgtat tcattctaat 18360 atatgtattt tttagatctg aattaaatat gttcttcatg cctaaacgaa aaatacccga 18420 tcctattgat agattacgac gtgctaatct agcgtgtgaa gacgataaat taatgatcta 18480 tggattacca tggatgacaa ctcaaacatc tgcgttatca ataaatagta aaccgatagt 18540 gtataaagat tgtgcaaagc ttttgcgatc aataaatgga tcacaaccag tatctcttaa 18600 cgatgttctt cgcagatgat gattcatttt ttaagtattt ggctagtcaa gatgatgaat 18660 cttcattatc tgatatattg ca aatcactc aatatctaga ctttctgtta ttattattga 18720 tccaatcaaa aaataaatta gaagccgtgg gtcattgtta tgaatctctt tcagaggaat 18780 acagacaatt gacaaaattc acagactttc aagattttaa aaaactgttt aacaaggtcc 18840 ctattgttac agatggaagg gtcaaactta ataaaggata tttgttcgac tttgtgatta 18900 gtttgatgcg attcaaaaaa gaatcctctc tagctaccac cgcaatagat cctattagat 18960 acatagatcc tcgtcgcgat atcgcatttt ctaacgtgat ggatatatta aagtcgaata 19020 aagtgaacaa taattaattc tttattgtca tcatgaacgg cggacatatt cagttgataa 19080 tcggccccat gttttcaggt aaaagtacag aattaattag acgagttaga cgttatcaaa 19140 tagctcaata taaatgcgtg actataaaat attctaacga taatagatac ggaacgggac 19200 tatggacgca tgataagaat aattttgaag cattggaagc aactaaacta tgtgatgtct 19260 tggaatcaat tacagatttc tccgtgatag gtatcgatga aggacagttc tttccagaca 19320 ttgttgaatt ctgtgagcgt atggcaaacg aaggaaaaat agttatagta gccgcactcg 19380 atgggacatt tcaacgtaaa ccgtttaata atattttgaa tcttattcca ttatctgaaa 19440 tggtggtaaa actaactgct gtgtgtatga aatgctttaa ggaggcttcc ttttctaaac 19500 gattgggtga ggaaa ccgag atagagataa taggaggtaa tgatatgtat caatcggtgt 19560 gtagaaagtg ttacgtcggc tcataatatt atatttttta tctaaaaaac taaaaataaa 19620 cattgattaa attttaatat aatacttaaa aatggatgtt gtgtcgttag ataaaccgtt 19680 tatgtatttt gaggaaattg ataatgagtt agattacgaa ccagaaagtg caaatgaggt 19740 cgcaaaaaaa ctgccgtatc aaggacagtt aaaactatta ctaggagaat tattttttct 19800 tagtaagtta cagcgacacg gtatattaga tggtgccacc gtagtgtata taggatctgc 19860 tcccggtaca catatacgtt atttgagaga tcatttctat aatttaggag tgatcatcaa 19920 atggatgcta attgacggcc gccatcatga tcctatttta aatggattgc gtgatgtgac 19980 tctagtgact cggttcgttg atgaggaata tctacgatcc atcaaaaaac aactgcatcc 20040 ttctaagatt attttaattt ctgatgtgag atccaaacga ggaggaaatg aacctagtac 20100 ggcggattta ctaagtaatt acgctctaca aaatgtcatg attagtattt taaaccccgt 20160 ggcgtctagt cttaaatgga gatgcccgtt tccagatcaa tggatcaagg acttttatat 20220 cccacacggt aataaaatgt tacaaccttt tgctccttca tattcagctg aaatgagatt 20280 attaagtatt tataccggtg agaacatgag actgactcga gttaccaaat cagacgctgt 20340 aaattatg aa aaaaagatgt actaccttaa taagatcgtc cgtaacaaag tagttgttaa 20400 ctttgattat cctaatcagg aatatgacta ttttcacatg tactttatgc tgaggaccgt 20460 gtactgcaat aaaacatttc ctactactaa agcaaaggta ctatttctac aacaatctat 20520 atttcgtttc ttaaatattc caacaacatc aactgaaaaa gttagtcatg aaccaataca 20580 acgtaaaata tctagcaaaa attctatgtc taaaaacaga aatagcaaga gatccgtacg 20640 cagtaataaa tagaaacgta ctactgagat atactaccga tatagagtat aatgatttag 20700 ttactttaat aaccgttaga cataaaattg attctatgaa aactgtgttt caggtattta 20760 acgaatcatc cataaattat actccggttg atgatgatta tggagaacca atcattataa 20820 catcgtatct tcaaaaaggt cataacaagt ttcctgtaaa ttttctatac atagatgtgg 20880 taatatctga cttatttcct agctttgtta gactagatac tacagaaact aatatagtta 20940 atagtgtact acaaacaggc gatggtaaaa agactcttcg tcttcccaaa atgttagaga 21000 cggaaatagt tgtcaagatt ctctaccgtc ctaatatacc attaaaaatt gttagatttt 21060 tccgcaataa catggtaact ggagtagaga tagccgatag atctgttatt tcagtcgctg 21120 attaatcaat tagtagagat gagataagaa cattataata atcaataata tattttatat 21180 cttatatctt gtttagaaaa atgctaatat taaaatagct aacgctagta atccaatcgg 21240 aagccatttg atatctataa tagggtatct aatttcctga ttcagatagc ggacagctat 21300 attctcggta gctactcgtt tggaatcaca aacattattt acatctaatt tactatctgt 21360 aatggaaacg tttcccaatg aaatggtaca atccgataca ttgcattttg ttatattttt 21420 ttttaaagag gctggtaaca acgcatcgct tcgtttacat ggctcgtacc aacaataata 21480 gggtaatctt gtatctattc ctatccgtac tatgctttta tcaggataaa tacatttaca 21540 tcgtatatcg tctttgttag catcacagaa tgcataaatt tgttcgtccg tcatgataaa 21600 aatttaaagt gtaaatataa ctattatttt atagttgtaa taaaaaggga aatttgattg 21660 tatactttcg gttctttaaa agaaactgac ttgataaaaa tggctgtaat ctctaaggtt 21720 acgtatagtc tatatgatca aaaagagatt aatgctacag atattatcat tagtcatgtt 21780 aaaaatgacg acgatatcgg taccgttaaa gatggtagac taggtgctat ggatggggca 21840 ttatgtaaaa cttgtgggaa aacggaattg gaatgtttcg gtcactgggg taaagtaagt 21900 atttataaaa ctcatatagt taagcctgaa tttatttcag aaattattcg tttactgaat 21960 tatatatgta ttcactgcgg attattgcgt tcacgagaac cgtattccga cgatattaa c 22020 ctaaaagagt tatcgggaca cgctcttagg agattaaagg ataaaatatt atccaagaaa 22080 aagtcatgtt ggaacagtga atgtatgcaa ccgtatcaaa aaattacttt ttcaaagaaa 22140 aaggtttgtt tcgtcaacaa gttggatgat attaacgttc ctaattctct catctatcaa 22200 aagttaattt ctattcatga aaagttttgg ccattattag aaattcatca atatccagct 22260 aacttatttt atacagacta ctttcccatc cctccgttga ttattagacc ggctattagt 22320 ttttggatag atagtatacc caaagaaacc aatgaattaa cttacttatt aggtatgatc 22380 gttaagaatt gtaacttgaa tgctgatgaa caggttatcc agaaggcggt aatagaatac 22440 gatgatatta aaattatttc taataacact tccagtatca atttatcata tatcacatcc 22500 ggcaaaaata atatgattag aagttatatc gtcgcccggc gaaaagatca gaccgctaga 22560 tctgtaattg gtcccagtac atctatcacc gttaatgagg taggaatgcc cgcatatatt 22620 agaaatacac ttacagaaaa gatatttgtt aatgccttta cagtggataa agttaaacaa 22680 ctattagcgt caaaccaagt taaattttac tttaataaac gattaaacca attaacaaga 22740 atacgccaag gaaagtttat caaaaataaa atacatttat tgcctggtga ttgggtagaa 22800 gtagctgttc aagaatatac aagtattatt tttggaagac agccgtctct a catagatac 22860 aacgtcatcg cttcatctat cagagctacc gaaggagata ctatcaaaat atctcccgga 22920 attgtcaact ctcaaaatgc tgatttcgac ggagatgaag aatggatgat attggagcaa 22980 aatcctaaag ccgtaattga acaaagtatt cttatgtatc cgacgacgtt actcaaacac 23040 gatattcatg gagcccccgt ttatggatct attcaagatg aaatcgtagc agcgtattca 23100 ttgtttagga tacaagatct ttgtttagat gaagtattga acatcttggg gaaatatgga 23160 agagagttcg atcctaaagg taaatgtaaa ttcagcggta aagatatcta tacttacttg 23220 ataggtgaaa agattaatta tccgggtctc ttaaaggatg gtgaaattat tgcaaacgac 23280 gtagatagta attttgttgt ggctatgagg catctgtcat tggctggact cttatccgat 23340 cataagtcga acgtggaagg tatcaacttt attatcaagt catcttatgt ttttaagaga 23400 tatctatcta tttacggttt tggggtgaca ttcaaagatc tgagaccaaa ttcgacgttc 23460 actaataaat tggaggccat caacgtagaa aaaatagaac ttatcaaaga agcatacgcc 23520 aaatatctca acgatgtaag agacgggaaa atagttccat tatctaaagc tttagaggcg 23580 gactatgtgg aatccatgtt atccaacttg acaaatctta atatccgaga gatagaagaa 23640 catatgagac aaacgctgat agatgatcca gataataacc tcct gaaaat ggccaaagcg 23700 ggttataaag taaatcccac agaactaatg tatattctag gtacttatgg acaacagagg 23760 attgatggtg aaccagcaga gactcgagta ttgggtagag tcttacctta ctatcttcca 23820 gactctaagg atccagaagg aagaggttac attcttaatt ctttaacaaa aggattaacg 23880 ggttctcaat attacttttc gatgctggtt gcaagatctc aatctactga tatcgtctgt 23940 gaaacatcac gtaccggaac actggctaga aaaatcatta aaaagatgga ggatatggtg 24000 gtcgacggat acggacaagt agttataggt aatacgctca tcaagtacgc cgccaattat 24060 accaaaattc taggctcagt atgtaaacct gtagatctta tctatccaga tgagtccatg 24120 acttggtatt tggaaattag tgctctgtgg aataaaataa aacagggatt cgtttactct 24180 cagaaacaga aacttgcaaa aaagacattg gcgccgttta atttcctagt attcgtcaaa 24240 cccaccactg aggataatgc tattaaggtt aaggatctgt acgatatgat tcataacgtc 24300 attgatgatg tgagagagaa atacttcttt acggtatcta atatagattt tatggagtat 24360 atattcttga cgcatcttaa tccttctaga attagaatta caaaagaaac ggctatcact 24420 atctttgaaa agttctatga aaaactcaat tatactctag gtggtggaac tcctattgga 24480 attatttctg cacaggtatt gtctgagaag tttacac aac aagccctgtc cagttttcac 24540 actactgaaa aaagtggtgc cgtcaaacaa aaacttggtt tcaacgagtt taataacttg 24600 actaatttga gtaagaataa gaccgaaatt atcactctgg tatccgatga tatctctaaa 24660 cttcaatctg ttaagattaa tttcgaattt gtatgtttgg gagaattaaa tccaaacatc 24720 actcttcgaa aagaaacaga taggtatgta gtagatataa tagtcaatag attatacatc 24780 aagagagcag aaattaccga attagtcgtc gaatatatga ttgaacgatt catctccttt 24840 agcgtcattg taaaggaatg gggtatggaa acattcattg aggatgagga taatattaga 24900 tttactgtct acctaaattt cgttgaaccg gaagaattga atcttagtaa gtttatgatg 24960 gttcttccgg gtgccgccaa caagggcaag attagtaaat tcaagattcc tatctctgat 25020 tatacgggat atgacgactt caatcaaaca aaaaagctca ataagatgac tgtagaactc 25080 atgaatctaa aagaattggg ttctttcgat ttggaaaacg tcaacgtgta tcctggagta 25140 tggaatacat acgatatctt cggtatcgag gccgctcgtg aatacttgtg cgaagccatg 25200 ttaaacacct atggagaagg gttcgattat ctgtatcagc cttgtgatct tctcgctagt 25260 ttactatgtg ctagttacga accagaatca gtgaataaat tcaagttcgg cgcagctagt 25320 actcttaaga gagctacgtt cggagacaat aaagcattgt taaacgcggc tcttcataaa 25380 aagtcagaac ctattaacga taatagtagc tgccactttt ttagcaaggt ccctaatata 25440 ggaactggat attacaaata ctttatcgac ttgggtcttc tcatgagaat ggaaaggaaa 25500 ctatctgata agatatcttc tcaaaagatc aaggaaatgg aagaaacaga agacttttaa 25560 ttcttatcaa taacatattt ttctatgatc tgtcttttaa acgatggatt ttccacaaat 25620 gcgcctctca agtccctcat agaatgatac acgtataaaa aatatagcat aggcaatgac 25680 tccttatttt tagacattag atatgccaaa atcatagccc cgcttctatt tactcccgca 25740 gcacaatgaa ccaacacggg ctcgtttcgt tgatcacatt tagataaaaa ggcggttacg 25800 tcgtcaaaat atttactaat atcggtagtt gtatcatcta ccaacggtat atgaataata 25860 ttaatattag agttaggtaa tgtatattta tccatcgtca aatttaaaac atatttgaac 25920 ttaacttcag atgatggtgc atccatagca tttttataat ttcccaaata cacattattg 25980 gttactcttg tcattatagt gggagatttg gctttgtgca tatctccagt tgaacgtagt 26040 agtaagtatt tatacaaact tttcttatcc atttataacg tacaaatgga taaaactact 26100 ttatcggtaa acgcgtgtaa tttagaatac gttagagaaa aggctatagt aggcgtacaa 26160 gcagccaaaa catcaacact ta tattcttt gttattatat tggcaattag tgcgctatta 26220 ctctggtttc agacgtctga taatccagtc tttaatgaat taacgagata tatgcgaatt 26280 aaaaatacgg ttaacgattg gaaatcatta acggatagca aaacaaaatt agaaagtgat 26340 agaggtagac ttctagccgc tggtaaggat gatatattcg aattcaaatg tgtggatttc 26400 ggcgcctatt ttatagctat gcgattggat aagaaaacat atctgccgca agctattagg 26460 cgaggtactg gagacgcgtg gatggttaaa aaggcggcaa aggtcgatcc atctgctcaa 26520 caattttgtc agtatttgat aaaacacaag tctaataatg ttattacttg tggtaatgag 26580 atgttaaatg aattaggtta tagcggttat tttatgtcac cgcattggtg ttccgatttt 26640 agtaatatgg aatagtgtta gataaatgcg gtaacgaatg ttcctgtaag gaaccataac 26700 agcttagatt taacgttaaa gatgagcata aacataataa acaaaattac aatcaaacct 26760 ataacattaa tatcaaacaa tccaaaaaat gaaatcagtg gagtagtaaa cgcgtacata 26820 actcctggat aacgtttagc agctgccgtt cctattctag accaaaaatt cggtttcatg 26880 ttttcgaaac ggtattctgc aacaagtcga ggatcgtgtt ctacatattt ggcggcgtta 26940 tccagtatct gcctattgat cttcatttcg ttttcgattc tggctatttc aaaataaaat 27000 cccgatgata gacct ccaga ctttataatt tcatctacga tgttcagcgc cgtagtaact 27060 ctaataatat aggctgataa gctaacatca taccctcctg tatatgtgaa tatggcatga 27120 tttttgtcca ttacaagctc ggttttaact ttattgcctg taataatttc tctcatctgt 27180 aggatatcta tttttttgtc atgcattgcc ttcaagacgg gacgaagaaa cgtaatatcc 27240 tcaataacgt tatcgttttc tacaataact acatattcta cctttttatt ttctaactcg 27300 gtaaaaaaat tagaatccca tagggctaaa tgtctagcga tatttctttt cgtttcctct 27360 gtacacatag tgttacaaaa ccctgaaaag aagtgagtat acttgtcatc atttctaatg 27420 tttcctccag tccactgtat aaacgcataa tccttgtaat gatctggatc atccttgact 27480 accacaacat ttcttttttc tggcataact tcattgtcct ttacatcatc gaacttctga 27540 tcattaatat gctcatgaac attaggaaat gtttctgatg gaggtctatc aataactggc 27600 acaacaataa caggagtttt caccgccgcc atttagttat tgaaattaat catatacaac 27660 tctttaatac gagttatatt ttcgtctatc cattgtttca catttacata tttcgacaaa 27720 aagatataaa atgcgtattc caatgcttct ctgtttaatg aattactaaa atatacaaac 27780 acgtcactgt ctggcaataa atgatatctt agaatattgt aacaatttat tttgtattgc 27840 acatgttcgt gatctatgag ttcttcttcg aatggcatag gatctccgaa tctgaaaacg 27900 tataaatagg agttagaata ataatatttg agagtattgg taatatataa actctttagc 27960 ggtataatta gtttttttct ctcgatttct atttttagat gtgatggaaa aatgactaat 28020 tttgtagcat tagtatcatg aactctaatc gagatcttaa tatcttcgtc acacgttag t 28080 tctttgaagt ttttaagaga tgcatcagtt ggttcgaccg atggagtagg tgcaacaatt 28140 ttttgttcga tgtatgtatg tactggagcc attgtcttaa ctataatggt gcttgtatcg 28200 aaaaacttta atgcagataa tggaagctct tcgccgcgac tttctacatc gtaattgggt 28260 tctaacgccg atctctgaat ggatactagt tttctaagtt ctaatgtgat tctctgaaaa 28320 tgtaaatcca attcctccgg cattatagat gtgtatacat cggtaaataa aactatagta 28380 tccaacgatc ccttctcgca aattctagtc ttaaccaaaa aatcgtatat aaccacggag 28440 atggcgtatt taagagtgga ttcttctacc gttttgttct tggatttcat ataagaaact 28500 ataaagtccg cactactgtt aagaatgatt actaacgcaa ctatatagtt taaattaagc 28560 atcttggaaa cataaaataa ctctgtagac gatacttgac tttcgaataa gtttgcagac 28620 aaacgaagaa agaacagacc tctcttaatt tcagaagaaa actttttttc gtattcctga 28680 cgtctagagt ttatatcaat aagaaagtta agaattagtc ggttaatgtt gtatttcatt 28740 acccaagttt gagatttcat aatattatca aaagacatga taatattaaa gataaagcgc 28800 tgactatgaa cgaaatagct atatggttcg ctcaagaata tagtcttgtt aaacgtggaa 28860 acgataactg tatttttaat cacgtcagcg gcatctaaat taaatatagg t atatttatt 28920 ccacacactc tacaatatgc cacaccatct tcataataaa taaattcgtt agcaaaatta 28980 ttaattttag tgaaatagtt agcgtcaact ttcatagctt ccttcaatct aatttgatgc 29040 tcacacggtg cgaattccac tctaacatcc cttttccatg cctcaggttc atcgatctct 29100 ataatatcta gttttttgcg tttcacaaac acaggctcgt ctctcgcgat gagatctgta 29160 tagtaactat gtaaatgata actagataga aagatgtagc tatatagatg acgatccttt 29220 aagagaggta tgatgacttt accccaatca gatagactgt tgttatggtc ttcggaaaaa 29280 gaatttttat aaatttttcc agtattttcc aaatatacgt acttaacatc taaaaaatcc 29340 ttaatgataa taggaatgga taatccgtct attttataaa gaaatacata tcgcacatta 29400 tacttttttt tggaaatggg aataccgatg tgtctacata aatatgcaaa gtctaaatat 29460 tttttagaga atcttagttg gtccaaattc ttttccaagt acggtaatag atttttcata 29520 ttgaacggta tcttcttaat ctctggttct agttccgcat taaatgatga aactaagtca 29580 ctatttttat aactaacgat tacatcacct ctaacatcat catttaccag aatactgatc 29640 ttcttttgtc gtaaatacat gtctaatgtg ttaaaaaaaa gatcatacaa gttatacgtc 29700 atttcatctg tggtattctt gtcattgaag gataaactcg tact aatctc ttctttaaca 29760 gcctgttcaa atttatatcc tatatacgaa aaaatagcaa ccagtgtttg atcatccgcg 29820 tcaatattct gttctatcgt agtgtataac aatcgtatat cttcttctgt gatagtcgat 29880 acgttataaa ggttgataac gaaaatattt ttatttcgtg agataaagtc atcgtaggat 29940 tttggactta tattcgcgtc tagtagatat gcttttattt ttggaatgat ctcaattaga 30000 atagtctctt tagagtccat ttaaagttac aaacaactag gaaattggtt tatgatgtat 30060 aattttttta gtttttatag attctttatt ctatacttaa aaaatgaaaa taaatacaaa 30120 ggttcttgag ggttgtgtta aattgaaagc gagaaataat cataaattat ttcattatcg 30180 cgatatccgt taagtttgta tcgtaatggc gtggtcaatt acaaataaag cggatactag 30240 tagcttcaca aagatggctg aaatcagagc tcatctaaaa aatagcgctg aaaataaaga 30300 taaaaacgag gatattttcc cggaagatgt aataattcca tctactaagc ccaaaaccaa 30360 acgagccact actcctcgta aaccagcggc tactaaaaga tcaaccaaaa aggaggaagt 30420 ggaagaagaa gtagttatag aggaatatca tcaaacaact gaaaaaaatt ctccatctcc 30480 tggagtcagc gacattgtag aaagcgtggc tgctgtagag ctcgatgata gcgacgggga 30540 tgatgaacct atggtacaag ttgaagctgg taaagta aat catagtgcta gaagcgatct 30600 ttctgaccta aaggtggcta ccgacaatat cgttaaagat cttaagaaaa ttattactag 30660 aatctctgca gtatcgacgg ttctagagga tgttcaagca gctggtatct ctagacaatt 30720 tacttctatg actaaagcta ttacaacact atctgatcta gtcaccgagg gaaaatctaa 30780 agttgttcgt aaaaaagtta aaacttgtaa gaagtaaatg cgtgcacttt tttataaaga 30840 tggtaaactc tttaccgata ataatttttt aaatcctgta tcagacgata atccagcgta 30900 tgaggttttg caacatgtta aaattcctac tcatttaaca gatgtagtag tatatgaaca 30960 aacgtgggag gaggcgttaa ctagattaat ttttgtggga agtgattcaa aaggacgtag 31020 acaatacttt tacggaaaaa tgcatgtaca gaatcgcaac gctaaaagag atcgtatttt 31080 tgttagagta tataacgtta tgaaacgaat taattgtttt ataaacaaaa atataaagaa 31140 atcgtccaca gattccaatt atcagttggc ggtttttatg ttaatggaaa ctatgttttt 31200 tattagattt ggtaaaatga aatatcttaa ggagaatgaa acagtagggt tattaacact 31260 aaaaaataaa cacatagaaa taagtcccga tgaaatagtt atcaagtttg taggaaagga 31320 caaagtttca catgaatttg ttgttcataa gtctaataga ctatataaac cgctattgaa 31380 actgacggat gattctagtc ccgaagaatt tctgttcaac aaactaagtg aacgaaaggt 31440 atacgaatgt atcaaacagt ttggtattag aatcaaggat ctccgaacgt atggagtcaa 31500 ttatacgttt ttatataatt tttggacaaa tgtaaagtcc atatctcctc ttccgtcacc 31560 aaaaaagtta atagcgttaa ctatcaaaca aactgctgaa gtggtaggtc atactccatc 31620 aatttcaaaa agagcttata tggcaacgac tattttagaa atggtaaagg ataaaaattt 31680 tttagatgta gtatctaaaa ctacgttcga tgaattccta tctatagtcg tagatcacgt 31740 taaatcatct acggatggat gatatagatc tttacacaaa taattacaag accgataaat 31800 ggaaatggat aagcgtatga aatctctcgc aatgacagct ttcttcggag agctaaacac 31860 attagatatt atggcattga taatgtctat atttaaacgc catccaaaca ataccatttt 31920 ttcagtggat aaggatggtc agtttatgat tgatttcgaa tacgataatt ataaggcttc 31980 tcaatatttg gatctgaccc tcactccgat atctggagat gaatgcaaga ctcacgcatc 32040 gagtatagcc gaacaattgg cgtgtgtgga tattattaaa gaggatatta gcgaatatat 32100 caaaactact ccccgtctta aacgatttat aaaaaaatac cgcaatagat cagatactcg 32160 tatcagtcga gatacagaaa agcttaaaat agctctagct aaaggcatag attacgaata 32220 tataaaagac gcttgttaat aa gtaaatga aaaaaaacta gtcgtttata ataaaacaca 32280 atatggatgc caacatagta tcatcttcta ctattgcaac gtatatagac gctttagcga 32340 agaatgcttc agaattagaa cagaggtcta ccgcatacga aataaataat gaattggaac 32400 tagtatttat taagccgcca ttaattactt tgacaaatgt agtgaatatc tctacgattc 32460 aggaatcgtt tattcgattt accgttacta ataaggaagg tgttaaaatt agaactaaga 32520 ttccattatc taaggtacat ggtctagatg taaaaaatgt acagttagta gatgctatag 32580 ataacatagt ttgggaaaag aaatcattag tgacggaaaa tcgtcttcac aaagaatgct 32640 tgttgagact atcgacagag gaacgtcata tatttttgga ttacaagaaa tatggatcct 32700 ctatccgact agaattagtc aatcttattc aagcaaaaac aaaaaacttt acgatagact 32760 ttaagctaaa atattttcta ggatccggtg cccagtctaa aagttcttta ttacacgcta 32820 ttaatcatcc aaagtcaagg cctaatacat ctctggaaat agaattcaca cctagagaca 32880 atgaaaaagt tccatatgat gaactaataa aggaattgac gactctatca cgtcatatat 32940 ttatggcttc tccagagaat gtaattcttt ctccgcctat taacgcgcct ataaaaacct 33000 ttatgttgcc taaacaagat atagtaggtt tggatctgga aaatctatat gccgtaacta 33060 agactgacgg aattc ctata actatcagag ttacatcaaa agggttgtat tgttatttta 33120 cacatcttgg ttatattatt agatatcctg ttaagagaat aatagattcc gaagtagtag 33180 tctttggtga ggcagttaag gataagaact ggaccgtata tctcattaag ctaatagagc 33240 ctgtgaatgc aatcaatgat agactagaag aaagtaagta tgttgaatct aaactagtgg 33300 atatttgtga tcggatagta ttcaagtcaa agaaatacga aggtccgttt actacaacta 33360 gtgaagtcgt cgatatgtta tctacatatt taccaaagca accagaaggt gttattctgt 33420 tctattcaaa gggacctaaa tctaacattg attttaaaat taaaaaggaa aatactatag 33480 accaaactgc aaatgtagta tttaggtaca tgtccagtga accaattatc tttggagaat 33540 cgtctatctt tgtagagtat aagaaattta gcaacgataa aggctttcct aaagaatatg 33600 gttctggtaa gattgtgtta tataacggcg ttaattatct aaataatatc tattgtttgg 33660 aatatattaa tacacataat gaagtgggta ttaagtccgt ggttgtacct attaagttta 33720 tagcagaatt cttagttaat ggagaaatac ttaaacctag aattgataaa accatgaaat 33780 atattaactc agaagattat tatggaaatc aacataatat catagtcgaa catttaagag 33840 atcaaagcat caaaatagga gatatcttta acgaggataa actatcggat gtgggacatc 33900 aatacgcc aa taatgataaa tttagattaa atccagaagt tagttatttt acgaataaac 33960 gaactagagg accgttggga attttatcaa actacgtcaa gactcttctt atttctatgt 34020 attgttccaa aacattttta gacgattcca acaaacgaaa ggtattggcg attgattttg 34080 gaaacggtgc ggacctggaa aaatactttt atggagagat tgcgttattg gtagcgacgg 34140 atccggatgc tgatgctata gctagaggaa atgaaagata caacaaatta aactctggaa 34200 ttaaaaccaa gtactacaaa tttgactaca ttcaggaaac tattcgatcc gatacatttg 34260 tctctagtgt cagagaagta ttctattttg gaaagtttaa tatcatcgac tggcagtttg 34320 ctatccatta ttcttttcat ccgagacatt atgctaccgt catgaataac ttatccgaac 34380 taactgcttc tggaggcaag gtattaatca ctaccatgga cggagacaaa ttatcaaaat 34440 taacagataa aaagactttt ataattcata agaatttacc tagtagcgaa aactatatgt 34500 ctgtagaaaa aatagctgat gatagaatag tggtatataa tccatcaaca atgtctactc 34560 caatgactga atacattatc aaaaagaacg atatagtcag agtgtttaac gaatacggat 34620 ttgttcttgt agataacgtt gatttcgcta caattataga acgaagtaaa aagtttatta 34680 atggcgcatc tacaatggaa gatagaccgt ctacaaaaaa ctttttcgaa ctaaatagag 34740 gagccattaa atgtgaaggt ttagatgtcg aagacttact tagttactat gttgtttatg 34800 tcttttctaa gcggtaaata ataatatggt atgggttctg atatccccgt tctaaatgca 34860 ttaaataatt ccaatagagc gatttttgtt cctataggac cttccaactg tggatactct 34920 gtattgttaa tagatatatt aatacttttg tcgggtaaca gaggttctac gtcttctaaa 34980 aataaaagtt tgataacatc tggcctgttc ataaataaaa acttggcgat tctatatata 35040 ctcttattat caaatctagc cattgtctta tagatgtgag ctactgtagg tgtaccattt 35100 gattttcttt ctaatactat atatttctct cgaagaagtt cttgcacatc atctgggaat 35160 aaaatactac tgttgagtaa atcagttatt ttttttatat cgatattgat ggacattttt 35220 atagttaagg ataataagta tcccaaagtc gataacgacg ataacgaagt atttatactt 35280 ttaggaaatc acaatgactt tatcagatca aaattaacaa aattaaagga gcatgtattt 35340 ttttctgaat atattgtgac tccagataca tatggatctt tatgcgtcga attaaatggg 35400 tctagttttc agcacggtgg tagatatata gaggtggagg aatttataga tgctggaaga 35460 caagttagat ggtgttctac atccaatcat atatctgaag atatgcacac tgataaattt 35520 gtcatttatg atatttatac gtttgattcg ttcaagaata aacgattggt atttgtaca g 35580 gtgcctccat cattaggaga tgatagctat ttgactaatc cgttattgtc tccgtattat 35640 cgtaattcag tagccagaca aatggtcaat gatatgattt ttaatcaaga ttcattttta 35700 aaatatttat tagaacatct gattagaagc cactatagag tttctaaaca tataacaata 35760 gttagataca aggataccga agaattaaat ctaacgagaa tatgttataa tagagataag 35820 tttaaggcgt ttgtattcgc ttggtttaac ggcgtttcgg aaaatgaaaa ggtactagat 35880 acgtataaaa aggtatctaa tttgatataa tgaattcagt gactgtatca cacgcgccat 35940 atactattac ttatcacgat gattgggaac cagtaatgag tcaattggta gagttttata 36000 acgaagtagc cagttggctg ctacgagacg agacgtcgcc tattcctgat aagttcttta 36060 tacagttgaa acaaccgctt agaaataaac gagtatgtgt gtgtggtata gatccgtatc 36120 cgaaagatgg aactggtgta ccgttcgaat caccaaattt tacaaaaaaa tcaattaagg 36180 agatagcttc atctatatct agattaaccg gagtaattga ttataaaggt tataacctta 36240 atataataga cggggttata ccctggaatt attacttaag ttgtaaatta ggagaaacaa 36300 aaagtcacgc gatctactgg gataagattt ccaagttact gctgcagcat ataactaaac 36360 acgttagtgt tctttattgt ttgggtaaaa cagatttctc gaatatacgg g caaagttag 36420 aatccccggt aactaccata gtcggatatc atccagcggc tagagaccgc caattcgaga 36480 aagatagatc atttgaaatt atcaacgttt tactggaatt agacaacaag gcacctataa 36540 attgggctca agggtttatt tattaatgct ttagtgaaat tttaacttgt gttctaaatg 36600 gatgcaacta ttagaggtaa tgatgttatc tttgttctta agactatagg tgtcccgtca 36660 gcgtgcagac aaaatgaaga tccaagattt gtagaagcat ttaaatgcga cgagttagaa 36720 agatatattg agaataatcc agaatgtaca ctattcgaaa gtcttaggga tgaggaagca 36780 tactctatag tcagaatttt catggatgta gatttagacg cgtgtctaga cgaaatagat 36840 tatttaacgg ctattcaaga ttttattatc gaggtgtcaa actgtgtagc tagattcgcg 36900 tttacagaat gcggtgccat tcatgaaaat gtaataaaat ccatgagatc taatttttca 36960 ttgactaagt ctacaaatag agataaaaca agttttcata ttatcttttt agacacgtat 37020 accactatgg atacattgat agctatgaaa cgaacactat tagaattaag tagatcatct 37080 gaaaatccac taaccagatc gatagacact gccgtatata ggagaaaaac aactcttcgg 37140 gttgtaggta ctaggaaaaa tccaaattgc gacactattc atgtaatgca accaccgcat 37200 gataatatag aagattacct attcacttac gtggatatga acaa caatag ttattacttt 37260 tctctacaac gacgattgga ggatttagtt cctgataagt tatgggaacc agggtttatt 37320 tcattcgaag acgctataaa aagagtttca aaaatattca ttaattctat aataaacttt 37380 aatgatctcg atgaaaataa ttttacaacg gtaccactgg tcatagatta cgtaacacct 37440 tgtgcattat gtaaaaaacg atcgcataaa catccgcatc aactatcgtt ggaaaatggt 37500 gctattagaa tttacaaaac tggtaatcca catagttgta aagttaaaat tgttccgttg 37560 gatggtaata aactgtttaa tattgcacaa agaattttag acactaactc tgttttatta 37620 accgaacgag gagaccatat agtttggatt aataattcat ggaaatttaa cagcgaagaa 37680 cccttgataa caaaactaat tctgtcaata agacatcaac tacctaagga atattcaagc 37740 gaattactct gtccgaggaa acgaaagact gtagaagcta acatacgaga catgttaata 37800 gattcagtgg agaccgatac ctatccggat aaacttccgt ttaaaaatgg tgtattggac 37860 ctggtagacg gaatgtttta ctctggagat gatgctaaaa aatatacgtg tactgtatca 37920 accggattta aatttgacga tacaaagttc gtcgaagaca gtccagaaat ggaagagtta 37980 atgaatatca ttaacgatat ccaaccatta acggatgaaa ataagaaaaa tagagagttg 38040 tacgaaaaaa ctttatctag ttgtttatgc ggtgcta cca aaggatgttt aacattcttt 38100 tttggagaaa ctgcaactgg aaagtcgaca accaaacgtt tgttaaagtc tgctatcggt 38160 gacctgtttg ttgagacggg tcaaacaatt ttaacagatg tattggataa aggacctaat 38220 ccatttatcg ctaacatgca tttgaaaaga tctgtattct gtagcgaact acctgatttt 38280 gcctgtagtg gatcaaagaa aattagatct gacaatatta aaaagttgac agaaccttgt 38340 gtcattggaa gaccgtgttt ctccaataaa attaataata gaaaccatgc gacaatcatt 38400 atcgatacta attacaaacc tgtctttgat aggatagata acgcattaat gagaagaatt 38460 gccgtcgtgc gattcagaac acacttttct caaccttctg gtagagaggc tgctgaaaat 38520 aatgacgcgt acgataaagt caaactatta gacgaggggt tagatggtaa aatacaaaat 38580 aatagatata gattcgcatt tctatacttg ttggtgaaat ggtacaaaaa atatcatgtt 38640 cctattatga aactatatcc tacaccggaa gagattccgg actttgcatt ctatctcaaa 38700 ataggtactc tgttagtatc tagctctgta aagcatattc cattaatgac ggacctctcc 38760 aaaaagggat atatattgta cgataatgtg gttactcttc cgttgactac tttccaacag 38820 aaaatatcca agtattttaa ttctagacta tttggacacg atatagagag cttcatcaat 38880 agacataaga aatttgccaa tgttagtgat gaatatctgc aatatatatt catagaggat 38940 atttcatctc cgtaaatata tgctcatata tttatagaag atatcacata tctaaatgaa 39000 taccggaatc atagatttat ttgataatca tgttgatagt ataccaacta tattacctca 39060 tcagttagct actctagatt atctagttag aactatcata gatgagaaca gaagcgtgtt 39120 attgttccat attatgggat caggtaaaac aataatcgct ttgttgttcg ccttggtagc 39180 ttccagattt aaaaaggttt acattctagt gcctaatatt aacattttga aaatttttaa 39240 ttataatatg ggtgtagcta tgaacttgtt taatgacgaa ttcatagctg agaatatctt 39300 tattcattcc acaacaagtt tttattctct taattataac gataacgtca ttaattataa 39360 cggattatct cgctacaata actctatttt tatcgttgat gaggcacata atatctttgg 39420 gaataatact ggagaactta tgaccgtgat aaaaaataaa aacaagattc cttttttact 39480 attgtctgga tctcccatta ctaacacacc taatactctg ggtcatatta tagatttaat 39540 gtccgaagag acgatagatt ttggtgaaat tattagtcgt ggtaagaaag taattcagac 39600 acttcttaac gaacgaggtg tgaatgtact taaggatttg cttaaaggaa gaatatcata 39660 ttacgaaatg cctgataaag atctaccaac gataagatat cacggacgta agtttctaga 39720 tactagagta gtatattgtc ac atgtctaa acttcaagag agagattata tgattactag 39780 acgacagcta tgttatcatg aaatgtttga taaaaatatg tataacgtgt caatggcagt 39840 attgggacaa cttaatctga tgaataattt agatacttta tttcaggaac aggataagga 39900 attgtaccca aatctgaaaa taaataatgg cgtgttatac ggagaagaat tggtaacgtt 39960 aaacattagt tccaaattta aatactttat taatcggata cagacactca acggaaaaca 40020 ttttatatac ttttctaatt ctacatatgg cggattggta attaaatata tcatgctcag 40080 taatggatat tctgaatata atggttctca gggaactaat ccacatatga taaacggcaa 40140 accaaaaaca tttgctatcg ttactagtaa aatgaaatcg tctttagagg atctattaga 40200 tgtgtataat tctcctgaaa acgatgatgg cagtcaattg atgtttttgt tttcgtcaaa 40260 cattatgtcc gaatcctata ctctgaaaga ggtaaggcat atttggttta tgactatccc 40320 agatactttt tctcaataca accaaattct tggacgatct attagaaaat tctcttacgc 40380 cgatatttct gaaccagtta atgtatatct tttagccgcc gtatattccg atttcaatga 40440 cgaagtgacg tcattaaacg attacacaca ggatgaatta attaatgttt taccatttga 40500 catcaaaaag ctgttgtatc taaaatttaa gactaaagaa acgaatagaa tatactctat 40560 tcttcaagag atgtc tgaaa cgtattctct tccaccacat ccatcaattg taaaagtttt 40620 attgggagaa ttggtcagac aattttttta taataattct cgtattaagt ataacgatac 40680 caagttactt aaaatggtta catcagttat aaaaaataaa gaagacgcta ggaattacat 40740 agatgatatt gtaaacggtc acttctttgt atcgaataaa gtatttgata aatctctttt 40800 atacaaatac gaaaacgata ttattacagt accgtttaga ctttcctacg aaccatttgt 40860 ttggggagtt aactttcgta aagaatataa cgtggtatct tctccataaa actgatgaga 40920 tatataaaga aataaatgtc gagctttgtt accaatggat accttccagt tacattggag 40980 ccacacgagc tgacgttaga cataaaaact aatattagga atgccgtata taagacgtat 41040 ctccatagag aaattagtgg taaaatggcc aagaaaatag aaattcgtga agacgtggaa 41100 ttacctctcg gcgaaatagt taataattct gtagttataa acgttccgtg tgtaataacc 41160 tacgcgtatt atcacgttgg ggatatagtc agaggaacat taaacatcga agatgaatca 41220 aatgtaacta ttcaatgtgg agatttaatc tgtaaactaa gtagagattc gggtactgta 41280 tcatttagcg attcaaagta ctgctttttt cgaaatggta atgcgtatga caatggcagc 41340 gaagtcactg ccgttctaat ggaggctcaa caaggtatcg aatctagttt tgtttttctc 41400 gcgaatatcg ttgactcata aaaaagagaa tagcggtaag tataaacacg aatactatgg 41460 caataattgc gaatgtttta ttcccttcga tatatttttg ataatatgaa aaacatgtct 41520 ctctcaaatc ggacaaccat ctcataaaat agttctcgcg cgctggagag gtagttgctg 41580 ctcgtataat ctccccagaa taatatactt gcgtgtcgtc gttcaattta tacggattt c 41640 tatagttctc tgttatataa tgcggttttc catcatgatt agacgacgac aatagtgttc 41700 taaatttaga tagttgatca gaatgaatgt ttattggcgt tggaaaaatt atccatacag 41760 cgtctgcaga gtggttgata gttgttccta gatatgtaaa ataatccaac ttactaggca 41820 gcaaattgtc tagataaaat actgaatcaa acggtgcaga cgtattggtg gatctaatgg 41880 aatccaattg attaactatc ttttgaaaat atacattttt atgatccgat acttgtaaga 41940 atatagaaat aatgataagt ccatcatcgt gtttttttgc ctcttcataa gaactatatt 42000 ttttcttatt ccaatgaaca agattaatct ctccagagta tttgtacaca tctatcaagt 42060 gattggatcc ataatcgtct tcctttcccc aatatatacg tagtgatgat aacacatatt 42120 cattggggag aaaccctcca cttatatatc ctcctttaaa attaatcctt actagttttc 42180 cagtgttctg gatagtggtt ggtttcgact cattataatg tatgtctaac ggcttcaatc 42240 gcgcgttaga aattgctttt ttagtttcta tattaatagg agatagttgt tgcggcatag 42300 taaaaatgaa atgataactg tttaaaaata gctcttagta tgggaattac aatggatgag 42360 gaagtgatat ttgaaactcc tagagaatta atatctatta aacgaataaa agatattcca 42420 agatcaaaag acacgcatgt gtttgctgcg tgtataacaa gtgacggata t ccgttaata 42480 ggagctagaa gaacttcatt cgcattccaa gcgatattat ctcaacaaaa ttcagattct 42540 atctttagag tatccactaa actattacgg tttatgtact acaatgaact aagagaaatc 42600 tttagacggt tgagaaaagg ttctatcaac gatatcgatc ctcactttga agagttaata 42660 ttattgggtg gtaaactaga taaaaaggaa tctattaaag attgtttaag aagagaatta 42720 aaagaggaaa gtgatgaacg tataacagta aaagaatttg gaaatgtaat tctaaaactt 42780 acaacacggg ataaattatt taataaagta tatataagtt attgcatggc gtgttttatt 42840 aatcaatcgt tggaggattt atcgcatact agtatttaca atgtagaaat tagaaagatt 42900 aaatcattaa atgattgtat taacgacgat aaatacgaat atctgtctta tatttataat 42960 atgctagtta atagtaaatg aacttttaca gatctagtat aattagtcag attattaagt 43020 ataatagacg actagctaag tctattattt gcgaggatga ctctcaaatt attacactca 43080 cggcattcgt taaccaatgc ctatggtgtc ataaacgagt atccgtgtcc gctattttat 43140 taactactga taacaaaata ttagtatgta acagacgaga tagttttctc tattctgaaa 43200 taattagaac tagaaacatg tctagaaaga aacgattatt tctgaattat tccaattatt 43260 tgtccaaaca ggaaagaagt atactatcgt catttttttc tcta gatcca gctactactg 43320 ataatgatag aatagatgct atttatccgg gtggcatacc caaaaggggt gagaatgttc 43380 cagagtgttt atccagggaa attaaagaag aagttaatat agacaattct tttgtattca 43440 tagacactcg gttttttatt catggcatca tagaagatac cattattaat aaattttttg 43500 aggtaatctt ctttgtcgga agaatatctt taacgagtga tcaaatcatt gatacattta 43560 aaagtaatca tgaaatcaag gatctaatat ttttagatcc gaattcaggt aatggactcc 43620 aatacgaaat tgcaaaatat gctctagata ctgcaaaact caaatgttat ggccatagag 43680 gatgttatta cgaatcatta aaaaaattaa ctgaggatga ttgattagaa aatataaatt 43740 aatttaccat cgtgtatttt tataacggga ttgtccggca tatcatgtag atagttaccg 43800 tctacatcgt atactcgacc atctacgcct ttaaatcctc tatttattga cattaatcta 43860 ttagaattgg aataccaaat attagtaccc tcaattagtt tattggtaat atttttttta 43920 gacgatagat cgatggctct tgaaaccaag gttttccaac cggactcatt gtcgatcggt 43980 gagaagtctt tttcattagc atgaatccat tctaatgatg tatgtttaaa cactctaaac 44040 aattggacaa attcttttga tttgctttga atgatttcaa ataggtcttc gtctacagta 44100 ggcataccat tagataatct agccattata aagtgca cgt ttacatatct acgttctgga 44160 ggagtaagaa cgtgactatt gagacgaatg gctcttccta ctatctgacg aagagacgcc 44220 tcgttccatg tcatatctaa aatgaagata tcattaattg agaaaaaact aataccctcg 44280 cctccactag aagagaatac gcatgtttta atgcattctc cgttagtgtt tgattcttgg 44340 ttaaactcag ccaccgcctt gattctagta tcttttgttc tagatgagaa ctctatatta 44400 gagataccaa agactttgaa atatagtaat aagatttcta ttcctgactg attaacaaat 44460 ggttcaaaga ctagacattt accatgggat gctaatattc ccaaacatac atctataaat 44520 ttgacgcttt tctcttttaa ttcagtaaat agagagatat cagccgcact agcatcccct 44580 ttcaatagtt ctcccttttt aaaggtatct aatgcggatt tagaaaactc tctatctctt 44640 aatgaatttt taaaatcatt atatagtgtt gctatctctt gcgcgtattc gcccggatca 44700 cgattttgtc tttcaggaaa gctatcgaac gtaaacgtag tagccatacg tctcagaatt 44760 ctaaatgatg atatacctgt ttttatttca gcgagtttag ccttttgata aatttcttct 44820 tgctttttcg acatattaac gtatcgcatt aatactgttt tcttagcgaa tgatgcagac 44880 ccttctacgt catcaaaaat agaaaactcg ttattaacta tgtacgaaca taggcctcct 44940 agtttggaga ctaattcttt ctcatcaact agacgtttat tctcaaatag cgattggtgt 45000 tgtaaggatc ctggtcgtag taagttaacc aacatggtga attcttgcac actattaacg 45060 ataggtgtag ccgataaaca aatcatctta tggtttttta atgcgatggt cttagataaa 45120 aaattatata ctgaacgagt aggacggatc ttaccatctt ctttgattaa tgatttagaa 45180 atgaagttat gacattcatc aataatgacg catattctac tcttggaatt aatagttttg 45240 atattagtaa aaaatttatt tctaaaattt tgatcatcgt aattaataaa aatacaatcc 45300 ttcgttatct ctggagcgta tctgagtata gtgttcatcc aaggatcttc tatcaaagcc 45360 tttttcacca ataagataat agcccaattc gtataaatat ccttaagatg tttgagaata 45420 tatacagtag tcattgtttt accaacaccc gtttcatgga acaataaaag agaatgcata 45480 ctgtctaatc ctaagaaaac tcttgctaca aaatgttgat aatccttgag gcgtactacg 45540 tctgttccca tcatttcaac aggcatatta gtagttctgc gcaatgcata atcgatatag 45600 gccgcgtgtg atttactcat ttatgagtga taagtaataa ctatgtttta aaaatcacag 45660 cagtagttta actagtcttc tctgatgttt gttttcgata ctttttgaat cagaagtcat 45720 actagaataa agcaacgagt gaacgtaata gagagcttcg tatactctat tcgaaaactc 45780 taagaactta ttaatgaatt cc gtatccac tggattgttt aaaatactaa attgaacact 45840 gttcacatcc ttccaagaag aagacttagt gacggactta acatgagaca taaataaatc 45900 caaatttttt ttacaaacat cactagccac cataatggcg ctatctttca accagctatc 45960 gcttacgcat tttagcagtc taacattttt aaagagacta caatatattc tcatagtatc 46020 gattacacct ctaccgaata aagttggaag tttaataata caatattttt cgtttacaaa 46080 atcaaataat ggtcgaaaca cgtcgaaggt taacatctta taatcgctaa tgtatagatt 46140 gttttcagtg agatgattat tagatttaat agcatctcgt tcacgtttga acagtttatt 46200 gtgtgcgctg aggtcggcaa ctacggcgtc cgctttagta ctcctcccat aatactttac 46260 gctattaatc tttaaaattt catagacttt atctagatcg ctttctggta acatgatatc 46320 atgtgtaaaa agttttaaca tgtcggtcgg cattctattt agatcattaa ctctagaaat 46380 ctgaagaaag taattagctc cgtattccag actaggtaat gggcttttac ctaaagacaa 46440 gttaagttct ggcaatgttt cataaaatgg aagaaggaca tgcgttccct cccggatatt 46500 ttttacaatt tcatccattt acaactctat agtttgtttt cattattatt agttattatc 46560 tcccataatc ttggtaatac ttaccccttg atcgtaagat accttataca ggtcattaca 46620 tacaactacc aattg ttttt gtacataata gattggatgg ttgacatcca tggtggaata 46680 aactactcga acagatagtt tatctttccc cctagataca ttggccgtaa tagttgtcgg 46740 cctaaagaat atctttggtg taaagttaaa agttagggtt cttgttccat tattgctttt 46800 tgtcagtagt tcattataaa ttctcgagat gggtccgttc tctgaatata gaacatcatt 46860 tccaaatcta acttctagtc tagaaataat atcggtctta ttcttaaaat ctattccctt 46920 gatgaaggga tcgttaatga acaaatcctt ggcctttgat tcggctgatc tattatctcc 46980 gttatagacg ttacgttgac tagtccaaag acttacagga atagatgtat cgatgatgtt 47040 gatactatgt gatatgtgag caaagattgt tctcttagtg gcatcactat atgttccagt 47100 aatggcggaa aactttttag aaatgttata tataaaagaa ttttttcgtg ttccaaacat 47160 tagcagatta gtatgaagat aaacactcat attatcagga acattatcaa tttttacata 47220 cacatcagca tcttgaatag aaacgatacc atcttctgga acctcaacaa tctcggcaga 47280 ctccggataa ccagtcggtg ggccatcact aacaataact agatcatcca acaatctact 47340 cacatatgca tctatataat ctttttcatc ttgtgagtac cctggatacg aaataaattt 47400 attatccgta tttccataat aaggtttagt ataaacagag agcgatgttg ccgcatgaac 47460 ttcagtta ca gtcgccgttg gttggtttat ttgacctatt actctcctag gtttctctat 47520 aaacgatggt ttaatttgta cattcttaac catatatcca ataaagctca attcaggaac 47580 ataaacaaat tctttgttga acgtttcaaa gtcgaacgaa gagtcacgaa taacgatatc 47640 ggatactgga ttgaaggtta ccgttacggt aatttttgaa tcggatagtt taagactgct 47700 gaatgtatct tccacatcaa acggagtttt aatataaacg tatactgtag atggttcttt 47760 aatagtgtca ttaggagtta ggccaataga aatatcatta agttcactag aatatccaga 47820 gtgtttcaaa gcaattgtat tattgataca attattatat aattcttcgc cctcaatttc 47880 ccaaataaca ccgttacacg aagagataga tacgtgatta atacatttat atccaacata 47940 tggtacgtaa ccgaatcttc ccataccttt aacttctgga agttccaaac tcagaaccaa 48000 atgattaagc gcagtaatat actgatccct aatttcgaag ctagcgatag cctgattgtc 48060 tggaccatcg tttgtcataa ctccggatag agaaatatat tgcggcatat acaaagttgg 48120 aatttgacta tcgactgcga agacattaga ccgtttaata gagtcatccc caccgatcaa 48180 agaattaatg atagtattat tcattttcta tttaaaatgg aaaaagctta caataaactc 48240 cgtagagaaa tatctataat ttgtgagttt tccttaaagt aacagcttcc gtaaacgccg 48300 tctttatctc ttagtaggtt tattgtattt atgacctttt ccttatcttc atagaatact 48360 aaaggcaaca aagaaatttt tggttcttct ctaagagcta cgtgagactt aaccatagaa 48420 gccaacgaat ccctacatat tttagaacag aaatacccaa cttcaccacc cttgaatgtc 48480 tcaatactaa taggtctaaa aaccaaatct tgattacaaa accaacactt atcaattaca 48540 ctatttgtct taatagacac atctgccata gatttataat actttggtag tatacaagcg 48600 agtgcttctt ctttagcggg cttaaagact gctttaggtg ctgaaataac cacatctgga 48660 aggcttactc gcttagccat ttaattacgg aactattttt ttatacttct aatgagcaag 48720 tagaaaacct ctcatctaca aaaacatact cgtgtccata atcctctacc atagttacac 48780 gttttttaga tctcatatgt gctaaaaagt tttcccatac taattggtta ctattatttt 48840 tcgtataatt tttaacagtt tgaggtttta gatttttagt tacagaagtg atatcgaata 48900 ttttatccaa aaagaatgaa taattaattg tcttagaagg agtgttttct tggcaaaaga 48960 ataccaagtg cttaaatatt tctactactt cattaatctt ttctgtactc agattcagtt 49020 tctcatcttt tacttgattg attatttcaa agactaactt ataatccttt ttatttattc 49080 tctcgttagc cttaagaaaa ctagatacaa aatttgcatc tacatcatcc gtggatatt t 49140 gatttttttc catgatatcc aagagttccg agataatttc tccagaacat tgatgagaca 49200 ataatctccg caatacattt ctcaaatgaa taagtttatt agacacatgg aagtttgact 49260 ttttttgtac ctttgtacat ttttgaaata cagactcgca aaaaatacaa tattcatatc 49320 cttgttcaga tactataccg ttgtgtctac aaccgctaca taatcgtaga ttcatgttaa 49380 cactctacgt atctcgtcgt ccaatatttt atataaaaac attttatttc tagacgttgc 49440 cagaaaatcc tgtaatattt ttagtttttt gggctgtgaa taaagtatcg ccctaatatg 49500 gttaccgtcc tccgccaata tagtagttaa attatccgca catgcagaag aacaccgctt 49560 aggcggattc agtacaatgt tatatttttc gtaccaactc atttaaatat cataatctaa 49620 aatagttctg taatatgtct agcgctaata tattgatcat aatcctgtgc ataaattaag 49680 atacaacaat gtctcgaaat catcgacatg gcttcttcca tagttagaag atcgtcgtca 49740 aagttagcaa cgtgattcat caacatttgc tgttttgagg cagcaaatac tgaaccgtcg 49800 ccattcaacc attcataaaa accatcgtct gaatccattg ataatttctt gtactggttt 49860 ttgagagctc gcatcaatct agcatttcta gctcccggat tgaaaacaga aagaggatcg 49920 tacatccagg gtccattttc tgtaaataga atcgtataat gtcccttcaa g aagatatca 49980 gacgatccac aatcaaagaa ttggtctccg agtttgtaac aaactgcgga ctttaaccta 50040 tacatgatac cgtttagcat gatttctggt gatacgtcaa tcggagtatc atctattaga 50100 gatctaaagc cggtgtaaca ttctccacca aacatattct tattctgacg tcgttctaca 50160 taaaacatca ttgctccatt aacgataaca ggggaatgaa cagcactacc catcacatta 50220 gttcccaatg gatcaatgtg tgtaactcca gaacatcttc catatcctat gttaggagga 50280 gcgaacacca ctcttccact attgccatcg aatgccatag aataaatatc cttggaattg 50340 atagaaatcg gactgtcgga tgttgtgatc atcttcatag gattaacaac tatgtatggt 50400 gccgcctgaa gtttcatatc gtaactgatg ccgtttatag gtctagccac agaaaccaac 50460 gtaggtctaa atccaactat agacaaaata gaagccaata tctgttcttc atctgtcata 50520 acttgagagc atccagtatg aataatcttc attagatggg gatctaccgc atcatcatcg 50580 ttacaataaa aaattcccat tctaatgttc ataattgctt ttctaatcat ggtatgcatg 50640 tttgctctct gaatctctgt ggaaattaga tctgatacac ctgtaatcac tatcggatta 50700 tcctccgtaa gacgattaac caacaacata taattataag actttacttt tctaaattca 50760 taaagttgct ggattaggct ataggtgtct ccatgtacat acgc gttctc gagcgcagga 50820 agtttaatac cgaatagtgc catcagaata ggatgaatat agtaattagt ttctggtttt 50880 ctataaataa aagacaaatc ttgtgaacta gacatatcgg taaaatgcat ggattggaat 50940 cgtgtagtcg acagaagaat atgatgatta gatggagagt atattttatc taactctttg 51000 agttggtcac cgattctagg actagctcga gaatgaataa gtactaaagg atgagtacat 51060 ttcacagaaa cactagcatt gttcaatgtg ctctttacat gggtaaggag ttgaaatagc 51120 tcgtttctat ttgttctgac aatatttagt ttattcataa tgttaagcat atcctgaata 51180 gtaaagttag atgtgtcata cttgttagta gttagatatt tagcaattgc attcccatca 51240 tttctcaatc tcgtactcca atcatgcgtg gatgctactt cgtcgatgga aaccatacaa 51300 tcctttttga taggctgttg agattgatta tttcctgcac gtttaggttt ggtacgttga 51360 tttctagccc ctgcggatat aaagtcatcg tctacaattt tggataatga attgcataca 51420 ctacaagaca aagatttatc agaagtgtga atatgatctt catctaccaa agaaagagtt 51480 tgattagtat aactagattt tagtcctgcg ttagatgtta aaaaaacatc gctattgacc 51540 acggcttcca ttatttatat tcgtagtttt tactcgaaag cgtgatttta atattcaatc 51600 ttattacttt tggaatcgtt caaaaccttt gactaat tgt agaatttgat ctattgccct 51660 acgcgtatac tcccttgcat catatacgtt cgtcaccaga tcgtttgttt cggcctgaag 51720 ttggtgcata tctctttcaa cattcgacat gagatcctta agggccatat cgtctagatt 51780 ttgttgagat gctgctcctg gatttggatt ttgttgtgct gttgtacata ctgtaccacc 51840 agtaggtgta ggagtacata cagtggccac aataggaggt tgaggaggtg taaccgttgg 51900 agtagtacaa gaaatacttc catccgattg ttgtgtacat gtagttgttg gtaacgtctg 51960 agaaggttgg gtagatggcg gcgtcgtcgt cttttgatct ttattaaatt tagagataat 52020 atcctgaaca gcattgctcg gcgtcaacgc tggaaggagt gaactcgccg gcgcatcagt 52080 atctgcagac agccaatcaa aaagattaga catatcagat gatgtattag tttgttgtcg 52140 tggttttggt gtaggagccg gtgtagctgt tggaaccggc tgtggagtta tatgaatagt 52200 tggttgtagc ggttggatag gctgtctgct ggcggccatc atattatctc tagctagttg 52260 ttctcgcaac tgtctttgat aatacgactc ttgagacttt agtcctattt caatcgcttc 52320 atcctttttc gtatccggat ccttttcttc agaataatag attgacgact ttggtgtaga 52380 ggattctgcc agcccctgtg agaacttgtt aaagaagtcc atttaaggct ttaaaattga 52440 attgcgatta taagattaaa tggcagacac agacgatatt atcgactatg aatccgatga 52500 tctcaccgaa tacgaggatg atgaagaaga ggaagaagat ggagagtcac tagaaactag 52560 tgatatagat cccaaatctt cttataagat tgtagaatca gcatccactc atatagaaga 52620 tgcgcattcc aatcttaaac atatagggaa tcatatatct gctcttaaac gacgctatac 52680 tagacgtata agtctatttg aaatagcggg tataatagca gaaagctata acttgcttca 52740 acgaggaaga ttacctctag tttcagaatt ttctgacgaa acgatgaagc aaaatatgct 52800 acatgtaatt atacaagaga tagaggaggg ttcttgtcct atagtcatcg aaaagaacgg 52860 agaattgttg tcggtaaacg attttgacaa agatggtcta aaattccatc tagactatat 52920 tatcaaaatt tggaaacttc aaaaacgata ttagaattta tacgaatatc gttctctaaa 52980 tgtcacaatc aagtctcgca tgttcagcaa tttattgtcg tactttatat cgtgttcatt 53040 aacgatatct tgcaaaatag taatgattct atcttccttc gatagatatt cttcagagat 53100 tattgtctta tattctttct tgttatcaga tatgaatttg ataagacttt gaacattatt 53160 gatacccgtc tgtttaattt tttctacaga tattttagtt ttggcagatt ctatcgtatc 53220 tgtcaataga catccaacat cgacattcga cgtcaattgt ctataaatca acgtataaat 53280 tttagaaata acattagcga at tgttgtgc attgatgtcg ttattctgaa acagtatgat 53340 tttaggtagc attttcttaa caaagagaac gtatttattg ttactcagtt gaacagatga 53400 tatatccaga ttactaacgc atctgattcc atataccaaa ctttcagaag aaatggtgta 53460 caattgtttg tattcattca atgtctcttt ttcagaaatt agtttagagt cgaatactgc 53520 aataattttc aagagatagt tttcatcaga taagatttta tttagtgtag atatgataaa 53580 actattgttt tgttggagaa cttgatacgc cgcgttctct gtagtcgacg ctctcaaatg 53640 ggaaacaatc tccattattt ttttggaatc ggatacaata tcttcggtat cttgacgcaa 53700 tctagtatac atagagttaa gagaaattag agtttgtaca ttaagcaaca tgtctctaaa 53760 tgtggctgca aacttttcct tttccacatc atctagttta ttatataccg atttcacaac 53820 ggcaccagat ttaaggaacc agaatgaaaa actctgataa ctacaatatt tcatcatagt 53880 tacgatttta tcatcttcta tagttggtgt aatagcgcat acctttttct ccaagactgg 53940 aaccaacgtc ataaaaatgt ttaaatcaaa atccatatca acatctgatg cgctaagacc 54000 agtctcgcgt tcaagattat ctttactaat ggtgacgaac tcatcgtata gaactctaag 54060 tttgtccatt atttatttac agatttagtt gtttaattta tttgtgctct tccagagttg 54120 ggatagtatt tttct aacgt cggtattata ttattaggat ctacgttcat atgtatcata 54180 atattaatca tccacgtttt gataaatcta tctttagctt ctgaaataac gtatttaaac 54240 aaaggagaaa aatatttagc tacggcatca gacgcaataa tatttagtt gttaacta 54180 tatttagtt gttacta 360 tatttagtat gttacta aacaccattc ccgcgtcaga ttgaatagga gtttgaatag tttgttttgg aaatagatcc 54420 ttcaataact tatagttggg tgggaaaaaa tcgattttat cactagactc tttctttttt 54480 actatcatta cctcatgaac tatttcttga atgagtatat gtattttctt tcctatatcg 54540 gacgcgttca ttggaaaata taccatgtcg ttaactataa gaatattttt atcctcgttt 54600 acaaactgaa taatatcaga tgtagttcgt aaacgaacta tatcatcacc agcacaacat 54660 ctaactatat gatatccact agtttccttt agtcgtttat tatcttgttc catattagca 54720 gtcattccat catttaagaa ggcgtcaaag ataataggga gaaatgacat tttggattct 54780 gttacaactt taccaaaatt aaggatatac ggacttacta tctttttctc aacgtcgatt 54840 tgatgaacac acgatgaaaa tgtacttcga tgagattgat catgtagaaa acaacaaggg 54900 atacaatatt tccacatatc atgaaatata ttaagaaatc ccaccttatt atatttcccc 54960 aaaggatcca tgcatgtaaa cattatgccg ttatcattaa taaagacttc tttctcatcg 55020 gatctgtaaa agttgttact gatttttttc attccaggat ctagataatt aataatgatg 55080 ggttttctat tcttattctt tgtattttgg catatcctag accagtaaac agtttccact 55140 ttggtaaaat cagcagactt ttgaacgcta ttaaacatgg cattaatggc aataactaa a 55200 aatgtaaaat atttttctat gttaggaata tggtttttca ctttaataga tatatggttt 55260 ttggccaaaa tgatagatat ttttttatcc gaggatagta aaatattatt agtcgccgtc 55320 tctataaaaa tgaagctagt ctcgatatcc aattttattc tagaattgat aggagtcgcc 55380 aaatgtacct tatacgttat atctcccttg atgcgttcca tttgtgtatc tatatcggac 55440 acaagatctg taaatagttt tacgttatta atcatcacgg tatcgccgtc gctagataac 55500 gctaatgtac catccaagtc ccaaatggag agatttaact gttcatcgtt tagaataaaa 55560 tgattaccgg tcatattaat aaagtgttca tcgtatctag ataacaacga cttataatta 55620 atgtccaagt cttgaactcg ctgaatgatc ttttttaacc cagttagttt tagattggta 55680 cgaaatatat tgttaaactt tgattctaca gtaatgtcca aatctagttg tggaaatact 55740 tccatcaaca ttgtttcaaa cttgataata ttattatcta catcttcata cgatccaaat 55800 tccggaatag atgtatcgca cgctctggcc acccagataa ccaaaaagtc acacgctcca 55860 ggatatacat tgtataaaaa gctatcgttt tttagtagtg tttttttctg agtatatacg 55920 aagggattaa aaatagtatt atcaacgtaa ctatattcca aattattctt atgagaatag 55980 ataataatat cgtccttaat atctaacaaa tttcctaaat atccctttaa t tgagtcatt 56040 cgaagcgtca atagaatatg tctcttaact atttccggct gttgtatatt taaatgactt 56100 cgtaaaaaat aatatatggg cgacttctca tctatgtaat catatggagt gagatatagg 56160 gctcgttcta cctcctgccc cttacccacc tgtaatacca attgcggact tactatatat 56220 cgcatattta tatcgtgggg taaagtgaaa atctactacc gatgatgtaa gtcttacaat 56280 gttcgaacca gtaccagatc ttaatttgga ggcctccgta gaactagggg aggtaaatat 56340 agatcaaaca acacctatga taaaggaaaa tagcggtttt atatcccgta gtagacgtct 56400 attcgcccat agatctaagg atgatgagag aaaactagca ctacgattct ttttacaaag 56460 actttatttt ttagatcata gagagattca ttatttgttc agatgcgttg acgctgtaaa 56520 agacgtcact attaccaaaa aaaataacat tatcgtggcg ccttatatag cacttttaac 56580 tatcgcatca aaaggatgca aacttacaga aacaatgatt gaagcattct ttccagaact 56640 atataatgaa catagtaaga aatttaaatt caactctcaa gtatccatca tccaagaaaa 56700 actcggatac cagtttggaa actatcacgt ttatgatttt gaaccgtatt actctacagt 56760 agctctggct attcgagatg aacattcatc tggcattttt aatatccgtc aagagagtta 56820 tctggtaagt tcattatctg aaataacata tagattttat ctaa ttaatc taaaatctga 56880 tcttgttcaa tggagtgcta gtacgggcgc tgtaattaat caaatggtaa atactgtatt 56940 gattacagtg tatgaaaagt tacaactggt catagaaaat gattcacaat ttacatgttc 57000 attggctgtg gaatcaaaac ttccaataaa attacttaaa gatagaaatg aattatttac 57060 aaaattcatc aacgagttaa aaaagaccag ttcattcaag ataagcaaac gcgataagga 57120 tacgctacta aaatatttta cttaggactg gagttagaat ttatagacga ctcatttcgt 57180 ttatcattat tagtattctt cttgttatct tgttcagaaa tatacagcaa tgctatgcct 57240 aatactaaat acattatcat gcttgcaatg gctctaacaa cgacgaacca aaatgaattt 57300 ggtcgtagct tttgttcaca aaaatacata aagaaatgtc tacataaatc tatggcgcca 57360 ttggctactt gaaatagcgc cagtcctcct acagatttta atatagctgt ataacatgac 57420 atttattcat catcaaaaga gacagagtca ccatctgtca tatttagatt ttttttcatg 57480 tgttcaaagt atcctctact catttcatta taatagttta tcatacttag aattttagga 57540 cggatcaatg agtaagactt gactagatcg tcagtagtaa tttgtgcatc gtctattctg 57600 catccgcttc gtcgaataat gtatagcatc gctttgagat tctccatagc tatcaagtct 57660 ttatacaatg acatggaaat atctgtgaat actttat act tctccaacat cgatgcctta 57720 acatcatcgc ctactttagc attgaaaata cgttctattg tgtagatgga tgtagcaaga 57780 tttttaaaca acaatgccat tttacacgat gattgcctca agtctccaat cgtttgttta 57840 gaacgattag ctacagagtc caatgcttgg ctgactagca tattattatc tttagaaatt 57900 gtattcttca atgaggcgtt tatcatatct gtgatttcgt tagtcatatt acagtctgac 57960 tgggttgtaa tgttatccaa catatcacct atggatacgg tacacgtacc agcatttgta 58020 ataatcctat ctaagatgtt gtatggcatt gcgcagaaaa tatcttctcc tgtaatattt 58080 ccactctcga taaatctact cagattattc ttaaatgcct tattctctgg agaaaagata 58140 tcagtgtcca tcatttcatt aatagtatac gcagaaaaga taccacgagt atcaattcta 58200 tccaagatac ttatcggttc cgagtcacag ataatggttt cctctccttc gggagatcct 58260 gcatagaaat atctaggaca atagtttcta tactgtctgt aactctgata atctctaaag 58320 tcactaactg ataccatgaa attgagaaga tcaaacgctg aagtaattaa tttttctgcc 58380 tcgtttttac tacaactagt tttcatcaat gtagtgacga tgtattgttt agttactctt 58440 ggtctaatac tgatgataga gatattatta cttcccataa tggatcttct agtagtcacc 58500 ttaaagccca ttgatgcaaa tagcagatag ataaagtctt ggtatgactc ctttctaata 58560 tagtacggac tacctttgtc acccaacttt atacccacat aagccataac aacctcttta 58620 atagccgttt catgaggttt atcagccatg agcctgagta gttggaagaa tctcatgaat 58680 cctgtctcag aaagtcctat atgcatgata gatttatctt tcctgggaaa ctctcgtata 58740 gtcatagatg aaatactctt caaagtttct gaaataagat tagtaacagt cttacctccg 58800 actactctag gtaacaaaca aactctaata ggtgttttct ctgcggagat aatatcagaa 58860 aggatagagc aataagtagt attattgtga ttataaagac cgaatacata acaggtagaa 58920 tttataaaca tcatgtcctg aaggttttta gacttgtatt cctcgtaatc cataccgtcc 58980 caaaacatgg atttggtaac tttgatagcc gtagatcttt gttccttcgc caacaggtta 59040 aagaaattaa taaagaattt gtggtttcta cctatgtcta caaattgcac gtttggaagc 59100 gccacggtta cattcactgc agcattttga ggatcgcgag tatgaagtac gatgttattg 59160 tttactggta tatctggaaa gaattctacc agtctaggaa taagagattg atatcgcata 59220 gaaatacaaa agttcataat ctcatcatct aagagcattt tgttaccatt gtaataaata 59280 tccactctgt catatgtata aatgaagtac tgttcaaaca tgatgagatg tttatatgtt 59340 ggcatagtag tgagatctac gt ttggtaat ggcaatgtat taagattaac tccataatgt 59400 ctagcagcat ctgcgatgtt ataagcgttg tcaaagcggg gtcgatcttg tgctgttata 59460 tattgtctaa cacctataag attatcaaaa tcttgtctgc ttaatacacc gttaacaatt 59520 tttgccttga attcttttat tggtgcatta ataacatcct tatagaggat gttaaacaaa 59580 taagtgttat caaagttaag atctggatat ttcttttctg ctagaacatc cattgagtcg 59640 gagccatctg gtttaatata accaccgata aatctagctc tgtattctgt atccgtcaat 59700 ctaatattaa gaaggtgttg agtgaaaggt ggaagatcgt aaaagctgtg agtattaatg 59760 ataggattag tttccgaact aatgttaatt ggggtattaa taatatctat atttccagcg 59820 ttaagtgtaa cattaaacag ttttaattca cgtgacgtgg tatcaattaa ataattaatg 59880 cccaatttgg atatagcagc ctgaagctca tcttgtttag ttacggatcc taatgagtta 59940 ttaagcaata tatcgaacgg atgaacgaag gttgttttaa gttggtcaca tactttgtaa 60000 tctagacata gatgcggaag aacggtagaa actatacgaa ataaatattc agagtcctct 60060 aattgatcaa gagtaactat tgacttaata ggcatcattt atttagtatt aaatgacgac 60120 cgtaccagtg acggatatac aaaacgattt aattacagag ttttcagaag ataattatcc 60180 atctaacaaa aatta tgaaa taactcttcg tcaaatgtct attctaactc acgttaacaa 60240 cgtggtagat agagaacata atgccgccgt agtgtcatct ccagaggaaa tatcctcaca 60300 acttaatgaa gatctatttc cagatgatga ttctccggcc actattatcg aacgagtaca 60360 acctcatact actattattg acgatactcc acctcctacg tttcgtagag agttattgat 60420 atcggaacaa cgtcaacaac gagaaaaaag atttaatatt acagtatcga aaaatgctga 60480 agcaataatg gaatctagat ctatgatatc ttctatgcca acacaaacac catccttggg 60540 agtagtttat gataaagata aaagaattca gatgttggag gatgaagtgg ttaatcttag 60600 aaatcaacga tctaatacaa aatcatctga taatttagat aattttacca gaatactatt 60660 tggtaagact ccgtataaat caacagaagt taataagcgt atagccatcg ttaattatgc 60720 aaatttgaac gggtctccct tatcagtcga ggacttggat gtttgttcag aggatgaaat 60780 agatagaatc tataaaacga ttaaacaata tcacgaaagt agaaaacgaa aaattatcgt 60840 cactaacgtg attattattg tcataaatat tatcgagcaa gcattgctaa aactcggatt 60900 tgaagaaatc aaaggactga gtaccgatat cacttcagaa attatcgatg tggagatcgg 60960 agatgactgc gatgctgtag catcaaaact aggaatcggt aacagtccgg ttcttaatat 61020 tgtattgt tt atactcaaga tattcgttaa acgaattaaa attatttaat ttaatacatt 61080 cccatatcca gacaacaatc gtctggatta atctgttcct gtcgtctcat accggacgac 61140 atattaatct ttttattagt aggcatcttt ttagatggtt tctttttccc agcattaact 61200 gagtcgatac ctagaagatc gtgattgatc tctccgacca ttccacgaac ttctaattgg 61260 ccgtctctga cggtaccata aactatttta ccagcattag taacagcttg gacaatctga 61320 ccatccatcg cattgtacga tgtagtagta actgttgttc tacgtctagg agcaccagaa 61380 gtatttttgg agcccttgga tgttgatgta gaagaagacg aggattttga ttttggttta 61440 catgtaatac attttgtatc acatgcgccg gcagtcacat ctgtttgaga attaagatta 61500 ttgttgcctc ctttgacggc tgcatctcca ccgatttgcg ctagtagatt tttaagctgt 61560 ggtgtaatct tattaactgt ttcgatataa tcatcgtaac tgcttctaac ggctaaattt 61620 tttttatccg ccatttagaa gctaaaaata tttttattta tgcagaagat ttaactagat 61680 tatacaatga actaatatga tccttttcca gattatttac aaacttggta ttttttggtt 61740 ctggaggagg cgaatttaaa ttcggacttg gatttggatt ttgtgggttc ttgatcttat 61800 tatacagcgc atataggatg gcgacggtaa ctgctacgca aataccgatc aacaaaagaa 61860 taccaatcat ttattgacaa taacttcact attgatcaag tatgcaatat atcatctttt 61920 cactaaataa gtagtaataa tgattcaaca atgtcgagat atatggacga taataattta 61980 gttcatggaa atatcgctat gattggtatg aatgactccg ctaactctgt ggggcgcgca 62040 gtgctttccc cacatagaat aaattagcat tccgactgtg ataataatac caagtataaa 62100 cgccataata ctcaatactt tccatgtacg agtgggactg gtagacttac taaagtcaat 62160 aaaggcgaag atacacgaaa gaatcaaaag aatgattcca gcgattagca cgccggaaaa 62220 ataatttcca atcataagca tcatatccat ttaactaata aaaattttaa atcgccgaat 62280 gaacaaagtg gaatataaac catataaaaa caatagtttg tactgcaaaa ataatatcta 62340 tttttgtttt cgaagatatg gtaaaattaa atagtagtac acagcatgtt ataactaaca 62400 gcagcaacgg ctcgtaatta cttatcattt actagacgaa aaggtggtgg gatattttct 62460 tgctcaaata atacgaatat atcacccatc cattttatgc gatgtttata tactctaatc 62520 tttaatagat ctatagacga cgggtttacc aacaatatag attttatcga ttcatctaat 62580 ttaaaccctt ccttaaacgt gaatgatcta ttatctggca taacgatgac tctacccgat 62640 gaatcggaca atgtactggg ccatgtagaa taaattatca acgaattatc gtctacgaa c 62700 atttatatca tttgttttaa ttttagtacg cgaataaata gatataaaat agaaaataac 62760 agatattaca accaatgtta tggccgcgcc cggccggccg cggccgcttt ttttctagac 62820 actaaataaa tagtaagatt aaattaatta taaaattatg tatataatat taattataaa 62880 attatgtata tgatttacta actttagtta gataaattaa taatacataa attttagtat 62940 attaatatta taaattaata atacataaat tttagtatat taatattata ttttaaatat 63000ttatttagtg tctagaaaaa aaggcctagc aggcc 63035 <210> 14 <211> 62068 <212> DNA <213> Artificial Sequence <220> <223> sMVA fragment 3 <400> 14 ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60 attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120 aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180 gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccgggt 240 attaataata tctatatttc cagcgttaag tgtaacatta aacagtttta attcacgtga 300 cgtggtatca attaaataat taatgcccaa tttggatata gcagcctgaa gctcatcttg 360 tttagttacg gatcctaatg agttattaag caatatatcg aacggatgaa cgaaggttgt 420 tttaagttgg tcacatactt tgtaatctag acatagatgc ggaagaacgg tagaaactat 480 acgaaataaa tattcagagt cctctaattg atcaagagta actattgact taataggcat 540 catttattta gtattaaatg acgaccgtac cagtgacgga tatacaaaac gatttaatta 600 cagagttttc agaagataat tatccatcta acaaaaatta tgaaataact cttcgtcaaa 660 tgtctattct aactcacgtt aacaacgtgg tagatagaga acataatgcc gccgtagtgt 720 catctccaga ggaaatatcc tcacaactta atgaagatct atttccagat gatgattctc 780 cggccactat tatcgaacga gtacaacctc atactactat tattgacgat actccacctc 840 ctacgtttcg t agagagtta ttgatatcgg aacaacgtca acaacgagaa aaaagattta 900 atattacagt atcgaaaaat gctgaagcaa taatggaatc tagatctatg atatcttcta 960 tgccaacaca aacaccatcc ttgggagtag tttatgataa agataaaaga attcagatgt 1020 tggaggatga agtggttaat cttagaaatc aacgatctaa tacaaaatca tctgataatt 1080 tagataattt taccagaata ctatttggta agactccgta taaatcaaca gaagttaata 1140 agcgtatagc catcgttaat tatgcaaatt tgaacgggtc tcccttatca gtcgaggact 1200 tggatgtttg ttcagaggat gaaatagata gaatctataa aacgattaaa caatatcacg 1260 aaagtagaaa acgaaaaatt atcgtcacta acgtgattat tattgtcata aatattatcg 1320 agcaagcatt gctaaaactc ggatttgaag aaatcaaagg actgagtacc gatatcactt 1380 cagaaattat cgatgtggag atcggagatg actgcgatgc tgtagcatca aaactaggaa 1440 tcggtaacag tccggttctt aatattgtat tgtttatact caagatattc gttaaacgaa 1500 ttaaaattat ttaatttaat acattcccat atccagacaa caatcgtctg gattaatctg 1560 ttcctgtcgt ctcataccgg acgacatatt aatcttttta ttagtaggca tctttttaga 1620 tggtttcttt ttcccagcat taactgagtc gatacctaga agatcgtgat tgatctctcc 1680 gaccattcca cgaacttct a attggccgtc tctgacggta ccataaacta ttttaccagc 1740 attagtaaca gcttggacaa tctgaccatc catcgcattg tacgatgtag tagtaactgt 1800 tgttctacgt ctaggagcac cagaagtatt tttggagccc ttggatgttg atgtagaaga 1860 agacgaggat tttgattttg gtttacatgt aatacatttt gtatcacatg cgccggcagt 1920 cacatctgtt tgagaattaa gattattgtt gcctcctttg acggctgcat ctccaccgat 1980 ttgcgctagt agatttttaa gctgtggtgt aatcttatta actgtttcga tataatcatc 2040 gtaactgctt ctaacggcta aatttttttt atccgccatt tagaagctaa aaatattttt 2100 atttatgcag aagatttaac tagattatac aatgaactaa tatgatcctt ttccagatta 2160 tttacaaact tggtattttt tggttctgga ggaggcgaat ttaaattcgg acttggattt 2220 ggattttgtg ggttcttgat cttattatac agcgcatata ggatggcgac ggtaactgct 2280 acgcaaatac cgatcaacaa aagaatacca atcatttatt gacaataact tcactattga 2340 tcaagtatgc aatatatcat cttttcacta aataagtagt aataatgatt caacaatgtc 2400 gagatatatg gacgataata atttagttca tggaaatatc gctatgattg gtatgaatga 2460 ctccgctaac tctgtggggc gcgcagtgct ttccccacat agaataaatt agcattccga 2520 ctgtgataat aataccaagt ataa acgcca taatactcaa tactttccat gtacgagtgg 2580 gactggtaga cttactaaag tcaataaagg cgaagataca cgaaagaatc aaaagaatga 2640 ttccagcgat tagcacgccg gaaaaataat ttccaatcat aagcatcata tccatttaac 2700 taataaaaat tttaaatcgc cgaatgaaca aagtggaata taaaccatat aaaaacaata 2760 gtttgtactg caaaaataat atctattttt gttttcgaag atatggtaaa attaaatagt 2820 agtacacagc atgttataac taacagcagc aacggctcgt aattacttat catttactag 2880 acgaaaaggt ggtgggatat tttcttgctc aaataatacg aatatatcac ccatccattt 2940 tatgcgatgt ttatatactc taatctttaa tagatctata gacgacgggt ttaccaacaa 3000 tatagatttt atcgattcat ctaatttaaa cccttcctta aacgtgaatg atctattatc 3060 tggcataacg atgactctac ccgatgaatc ggacaatgta ctgggccatg tagaataaat 3120 tatcaacgaa ttatcgtcta cgaacattta tatcatttgt tttaatttta gtacgcgaat 3180 aaatagatat aaaatagaaa ataacagata ttacaaccaa tgttatggcc gcgcccaacc 3240 aggtaggcag ttttatttta tcttttacta caggttctcc tggatgtacg tcaccaacgg 3300 cggacgtagt tctagtacaa ttagacgtaa gttccgcttg ggaatttttt aacgctaaag 3360 agttaacgtt aatcgtgcac ccaacgtatt tacatctagt tctttgaaca tcttgattat 3420 aatataacca ttttctatct ctagattcgt cggtgcactc atgtaaccaa cataccctag 3480 gtcctaaata tttatctccg gaattagatt ttggataatt cgcgcaccaa caatttctat 3540 ttcctttatg atcgttacaa aagacgtata atgccgtatc cccaaaagta aaataatcag 3600 gacgaataat tctaataaac tcagaacaat atctcgcatc catatgtttg gagcaaatat 3660 cggaataagt agacatagcc ggtttccgtt ttgcacgtaa ccattctaaa caattggggt 3720 ttccaggatc gtttctacaa aatccagtca tgaaatcatc acaatgttct gtcttgtaat 3780 tattattaaa tatttttgga cagtgtttgg tatttgtctt agaacaacat tttgccacgc 3840 tatcactatc gcccaggaga taatcctttt ttataaaatg acatcgttgc ccggatgcta 3900 tataatcagt agcgtgtttt aaatccttaa tatattcagg agttacctcg ttctgataat 3960 agattaatga tccaggacga aatttgaaag aactacatgg ttctccatga attaatacat 4020 attgtttagc aaattcagga actataaaac tactacaatg atctatcgac ataccatcta 4080 tcaaacaaaa cttgggttta atttctcccg gagatgtttc ataatagtac gtataacttt 4140 cttctgcaaa cttaacagct ctattatatt caggataatt aaaacctaat tccatatatt 4200 tgtctcgtat atctgctatt cctggtgcta ttttg attct attaagagta acggctgccc 4260 ccatttttaa taatcgtcag tatttaaact gttaaatgtt ggtatatcaa catttacctt 4320 atttcccgca gtataaggtt tgttgcaggt atactgttca ggaatggtta catttatact 4380 ttttctatag tcctgtcttt cgatgttcat cacatatgca aagaacagaa taaacaaaat 4440 aatgtaagaa ataatattaa atatctgtga attcgtaaat acattgattg ccataataat 4500 tacagcagct acaatacata caatagacat tcccacagtg ttgccattac ctccacgata 4560 catttgagtt actaagcaat aggtaataac taagctagta agaggcaata gaaaagatga 4620 gataaatatc atcaatatag agattagagg agggctatat agagccaaga cgaacaaaat 4680 caaaccgagt aacgttctaa catcattatt tttgaagatt cccaaataat cattcattcc 4740 tccataatcg ttttgcatca tacctccatc tttaggcata aacgattgct gctgttcctc 4800 tgtaaataaa tctttatcaa gcactccagc acccgcagag aagtcgtcaa gcatattgta 4860 atatcttaaa taactcattt atatattaaa aaatgtcact attaaagatg gagtataatc 4920 tttatgccga actaaaaaaa atgacttgtg gtcaacccct aagtcttttt aacgaagacg 4980 gggatttcgt agaagttgaa ccgggatcat cctttaagtt tctgatacct aagggatttt 5040 acgcctctcc ttccgtaaag acgagtctag tatttgaaac attaacaacg accgataata 5100 aaattactag tatcaatcca acaaatgcgc caaagttata tcctcttcaa cgcaaagtcg 5160 tatctgaagt agtttctaat atgaggaaaa tgatcgaatc aaaacgtcct ctatacatca 5220 ctcttcactt ggcgtgtgga tttggtaaga ctattaccac gtgttatctt atggctacac 5280 acggtagaaa aaccgtcatt tgcgtaccca ataaaatgtt aatacatcaa tggaagacac 5340 aggtagaggc agtcggattg gaacataaga tatccataga tggagtaagt agtctattaa 5400 aggaactaaa gactcaaagt ccggatgtat taatagtagt cagtagacat ctgacaaacg 5460 atgccttttg taaatatatc aataagcatt atgatttgtt catcttggat gaatcacata 5520 cgtataatct gatgaacaat acagcagtta caagattttt agcgtattat cctccgatga 5580 tgtgttattt tttaactgct acacctagac catctaacag aatttattgt aacagtatta 5640 ttaatattgc caagttatcc gatctaaaaa aaactatcta tgcagtagat agtttttttg 5700 agccatattc cacagataat attagacata tgataaaacg attagatgga ccatctaata 5760 aatatcatat atataccgag aagttattat ctgtagacga gcctagaaat caacttattc 5820 ttaataccct ggtagaagaa ttcaagtcag gaactattaa tcgcatttta gttattacta 5880 aactacgtga acatatggta ttcttctaca aacgattatt agattt tttc ggatcagagg 5940 ttgtatttat aggagacgcc caaaatagac gtactccaga tatggtcaaa tcaatcaagg 6000 aactaaatag atttatattc gtatccacct tattttattc cggtactggt ttagatattc 6060 ctagtttgga ttctttgttc atttgctcgg cagtaatcaa caatatgcaa atagagcaat 6120 tactagggag ggtatgtcga gaaacagaac tattagatag gacggtatat gtatttccta 6180 gcacatccat caaagaaata aagtacatga taggaaattt cgttcaacga attattagtc 6240 tgtctgtaga taaactagga tttaaacaaa aaagttatcg gaaacatcaa gaatccgatc 6300 ccacttctgt atgtacaaca tcctccagag aagaacgtgt attaaataga atatttaact 6360 cgcaaaatcg ttaagaagtt taagcgacga tccgcatgct gcgcaggcca gtgtattacc 6420 cctcatagta ttaatataat ccaatgatac ttttgtgatg tcggaaatct taaccaattt 6480 agactgacag gcagaacacg tcatgcaatc atcatcgtca tcgataactg tagtcttggg 6540 cttctttttg cggctcttca ttccggaacg cacattggtg ctatccattt aggtagtaaa 6600 aaataagtca gaatatgccc tatagcacga tcgtgcaaaa cctggtatat cgtctctatc 6660 tttatcacaa tatagtgtat cgacatcttt attattattg acctcgttta tcttggaaca 6720 tggaatggga acatttttgt tatcaacggc cacctttgcc ttaattccag a tgttgtaaa 6780 attataacta aacagtctat catcgacaca aatgaaattc ttgtttagac gtttgtagtt 6840 tacgtatgcg gctcgttcgc gtctcatttt ttcagatatt gcaggtacta taatattaaa 6900 aataagaatg aaataacata ggattaaaaa taaagttatc atgacttcta gcgctgattt 6960 aactaactta aaagaattac ttagtctgta caaaagtttg aaattttcag attctgcggc 7020 tatagaaaag tataattctt tggtagaatg gggaacatct acttactgga aaataggcgt 7080 gcaaaaggta gctaatgtcg agacgtcaat atctgattat tatgatgagg taaaaaataa 7140 accgtttaat attgatccgg gctattacat tttcttaccg gtatattttg ggagcgtctt 7200 tatttattcg aagggtaaaa atatggtaga acttggatct ggaaactctt ttcaaatacc 7260 agatgatatg cgaagtgcgt gtaacaaagt attagacagc gataacggaa tagactttct 7320 gagatttgtt ttgttaaaca atagatggat aatggaagat gctatatcaa aatatcagtc 7380 tccagttaat atatttaaac tagctagtga gtacggatta aacataccca aatatttaga 7440 aattgaaata gaggaagaca cattatttga cgacgagtta tactctatta tagaacgctc 7500 tttcgatgat aaatttccaa aaatatccat atcgtatatt aagttgggag aacttaggcg 7560 gcaagttgta gactttttca aattctcatt catgtatatt gagtccatca aggtaga tcg 7620 tataggagat aatattttta ttcctagcgt tataacaaaa tcaggaaaaa agatattagt 7680 aaaagatgta gaccatttaa tacgatccaa ggttagagaa catacatttg taaaagtaaa 7740 aaagaaaaac acattttcca ttttatacga ctatgatgga aacggaacag aaactagagg 7800 agaagtaata aaacgaatta tagacactat aggacgagac tattatgtta acggaaagta 7860 tttctctaag gttggtagtg caggcttaaa gcaattgact aataaattag atattaatga 7920 gtgcgcaact gtcgatgagt tagttgatga gattaataaa tccggaactg taaaacgaaa 7980 aataaaaaac caatcagcat ttgatttaag cagagaatgt ttgggatatc cagaagcgga 8040 ttttataacg ttagttaata acatgcggtt caaaatagaa aattgtaagg ttgtaaattt 8100 caatattgaa aatactaatt gtttaaataa cccgagtatt gagactatat atggaaactt 8160 taaccagttc gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat tattcgagtg 8220 aaataatatg cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt ttagaagtca 8280 aggataactc cgttagggta ttggatatat caaaattaga ctggagttct gattgggaaa 8340 ggcacatagc taaagatttg tcacaatatg aatacactac agttcttcta gaacgtcagc 8400 ctagaaggtc gccgtacgtc aaatttatct attttattaa aggcttttta tatcatacat 84 60 cggctgccaa agttatttgc gtctcgcctg tcatgtctgg taattcatat agagatcgaa 8520 aaaagagatc ggtcgaagca tttcttgatt ggatggacac attcggattg cgagactccg 8580 ttccggatag acgcaaatta gacgatgtag cggatagttt caatttggct atgagatacg 8640 tattagataa atggaatact aattatacac cttataatag gtgtaaatct agaaattaca 8700 taaaaaaaat gtaataacgt tagtaacgcc attatggata atctatttac ctttctacat 8760 gaaatagaag atagatatgc cagaactatt tttaactttc atctaataag ttgcgatgaa 8820 ataggagata tatatggtct tatgaaagaa cgcatttcct cagaggatat gtttgataat 8880 atagtgtata ataaagatat acatcatgcc attaagaaac tagtgtattg cgacatccaa 8940 cttactaaac acattattaa tcagaatacg tatccggtat ttaacgattc ttcacaagtg 9000 aaatgttgtc attatttcga tataaactca gataatagca atattagctc tcgtacagta 9060 gagatatttg agagggaaaa gtcatctctt gtatcatata ttaaaactac caataagaag 9120 agaaaggtca attatgggga aataaagaaa actgtacatg gaggcactaa tgcaaattac 9180 ttttccggta aaaagtctga tgagtatctg agcactacag tcaggtccaa cattaatcaa 9240 ccttggatca aaaccatttc taagagaatg agagtagata tcattaatca ctctatagta 9300 acg cgtggaa aaagctctat attacaaact atagaaatta tttttactaa tagaacatgt 9360 gtgaaaatat tcaaggattc tactatgcac attattctat ccaaggacaa ggatgaaaag 9420 gggtgtatac acatgattga caaattattc tatgtctatt ataatttatt tctgttgttc 9480 gaggatatca tccaaaacga gtactttaaa gaagtagcta atgttgtaaa ccacgtactc 9540 acggctacgg cattagatga gaaattattc ctaattaaga aaatggctga acacgatgtt 9600 tatggagtta gcaatttcaa aatagggatg tttaacctga catttattaa gtcgttggat 9660 cataccgttt tcccctctct gttagatgag gatagcaaaa taaagttttt taaggggaaa 9720 aagctcaata ttgtagcatt acgatctctg gaggattgta taaattacgt gactaaatcc 9780 gagaatatga tagaaatgat gaaggaaaga tcgactattt taaatagcat agatatagaa 9840 acggaatcgg tagatcgtct aaaagaattg cttctaaaat gaaaaaaaaa cactaattca 9900 gaaatggatc aacgactcgg atataagttt ttggtgcctg atcctaaagc cggagttttt 9960 tatagaccgt tacatttcca atatgtatcg tattctaatt ttatattgca tcgattgcat 10020 gaaatcttga ccgtcaagcg gccactctta tcgtttaaga ataatacaga acgaattatg 10080 atagaaatta gcaatgttaa agtgactcct ccagattact cacctataat cgcgagtatt 10140 aaaggt aaga gttatgacgc attagccacg ttcactgtaa atatctttaa agaggtaatg 10200 accaaagagg gtatatccat cactaaaata agtagttatg agggaaaaga ttctcatttg 10260 ataaaaattc cgctactaat aggatacggg aataaaaatc cacttgatac agccaagtat 10320 cttgttccta atgtcatagg tggagtcttt atcaataaac aatctgtcga aaaagtagga 10380 attaatctag tagaaaagat tacaacatgg ccaaaattta gggttgttaa gccaaactca 10440 ttcactttct cgttttcctc cgtatcccct cctaatgtat taccgacaag atatcgccat 10500 tacaagatat ctctggatat atcacaattg gaagcgttga atatatcatc gacaaagaca 10560 tttataacgg tcaatattgt tttgctgtct caatatttat ctagagtgag tctagaattc 10620 attagacgta gtttatcata cgatatgcct ccagaagttg tctatctagt aaacgcgata 10680 atagatagtg ctaaacgaat tactgaatct attactgact ttaatattga tacatacatt 10740 aatgacctgg tggaagctga acacattaaa caaaaatctc agttaacgat caacgagttc 10800 aaatatgaaa tgctgcataa ctttttacct catatgaact atacacccga tcaactaaag 10860 ggattttata tgatatcttt actaagaaag tttctctact gtatctacca cacttctaga 10920 tatccagata gagattcgat ggtttgtcat cgcatcctaa cgtacggcaa atattttgag 1098 0 acgttggcac atgatgaatt agagaattac ataggcaaca tccgaaacga tatcatgaac 11040 aatcacaaga acagaggcac ttacgcggta aacattcatg tactaacaac tcctggactt 11100 aatcatgcat tttctagtct attgagtgga aagttcaaaa agtcagacgg tagttatcga 11160 acacatcctc actattcatg gatgcagaat atttctattc ctaggagtgt tggattttat 11220 ccggatcaag taaagatttc aaagatgttt tctgtcagaa aataccatcc aagtcaatat 11280 ctttactttt gttcatcgga cgttccggaa agaggtcctc aggtaggttt agtatctcaa 11340 ttgtctgtct tgagttccat tacaaatata ctaacgtctg agtatttgga tttggaaaag 11400 aaaatttgtg agtatatcag atcatattat aaagatgata taagttactt tgaaacagga 11460 tttccaatca ctatagaaaa tgctctagtc gcatctctta atccaaatat gatatgtgat 11520 tttgtaactg actttagacg tagaaaacgg atgggattct tcggtaactt ggaggtaggt 11580 attactttag ttagggatca catgaatgaa attcgcatta atattggagc gggaagatta 11640 gtcagaccat tcttggttgt ggataacgga gagctcatga tggatgtgtg tccggagtta 11700 gaaagcagat tagacgacat gacattctct gacattcaga aagagtttcc gcatgtcatc 11760 gaaatggtag atatagaaca atttactttt agtaacgtat gtgaatcggt tcaaaaa ttt 11820 agaatgatgt caaaggatga aagaaagcaa tacgatttat gtgactttcc tgccgaattt 11880 agagatggat atgtagcatc ttcactagtg ggaatcaatc acaattctgg acccagagct 11940 attcttggat gtgctcaagc taaacaagct atctcttgtc tgagctcgga tatacgaaat 12000 aaaatagaca atggaattca tttgatgtat ccagagaggc caatcgtgat tagtaaggct 12060 ttagaaactt caaagattgc ggctaattgc ttcggccaac atgttactat agcattaatg 12120 tcgtacaaag gtatcaatca agaggatgga attatcatca aaaaacaatt tattcagaga 12180 ggcggtctcg atattgttac agccaagaaa catcaagtag aaattccgtt ggaaaacttt 12240 aataacaaag aaagagatag gtctaacgcc tattcaaaat tagaaagtaa tggattagtt 12300 agactgaatg ctttcttgga atccggagac gctatagcac gaaatatctc atcaagaact 12360 cttgaagatg attttgctag agataatcag attagctttg atgtttccga aaaatatacc 12420 gatatgtaca aatctcgcgt tgaacgagta caagtagaac ttactgacaa agttaaggta 12480 cgagtattaa ccatgaaaga aagaagaccc attctaggag acaaatttac cactagaacg 12540 agtcaaaagg gaacagtcgc gtatatcgcg gatgaaacgg aacttccata cgatgaaaat 12600 ggtatcacac cagatgtcat tattaattct acatccatct tctctagaaa aactatatct 12660 atgttgatag aggttatttt aacagccgca tattctgcta agccgtacaa caataaggga 12720 gaaaaccgac ctgtctgttt tcctagtagt aacgaaacat ccatcgatac atatatgcaa 12780 ttcgctaaac aatgttatga gcattcaaat ccgaaattgt ctgatgaaga attatcggat 12840 aaaatctttt gtgaaaagat tctctatgat cctgaaacgg ataagcctta tgcatccaaa 12900 gtattttttg gaccaattta ttacttgcgt ctgaggcatt taactcagga caaggcaacc 12960 gttagatgta gaggtaaaaa gacgaagctc attagacagg cgaatgaggg acgaaaacgt 13020 ggaggaggta tcaagttcgg agaaatggag agagactgtt taatagcgca tggtgcagcc 13080 aatactatta cagaagtttt gaaagattcg gaagaagatt atcaagatgt gtatgtttgt 13140 gaaaattgtg gagacatagc agcacaaatc aagggtatta atacatgtct tagatgttca 13200 aaacttaatc tctctcctct cttaacaaaa attgatacca cgcacgtatc taaagtattt 13260 cttactcaaa tgaacgccag aggcgtaaaa gttaaattag atttcgaacg aaggcctcct 13320 tcgttttata aaccattaga taaagttgat ctcaaaccgt cttttctggt gtaatattct 13380 agtttggtag tagatacata tcaatatcat caaattcgag atccgaatta taaaatgggc 13440 gtggattgtt aactatagaa tcggacgtct gatattcgaa aa tctgtgga gttttaggtt 13500 ttggtggagg tgtaactgct acttgggata ctgaagtctg atattcagaa agctggggga 13560 tgttctggtt cgacatccac cgatggtgtc acatcactcactaa tcggtacatcggt tggct gacgtcattggt ttaggt gacgtcattggt 13620 gacctctgtgt acttcaatgc gaggaaatgt ataatttggt aatggtttct catgtggatc tgaagaagag 13740 gtaagatatc tactagaaag ataccgatca cgttctagtt ctcttttgta gaacttaact 13800 ttttctttct ccgcatctag ttgatattcc aacctcttca cgttcgcatg ggttacctcc 13860 gcagttttta cgagcgattt cacgttcagc cttcatgcgt cttatagcat gaattcgctt 13920 atcgttatcg ggtttagctt ctgtcacctt agcaattcct tttttattaa actctacata 13980 atcatatcca tttctattgt ttgttctaat ataaacgagt atagcatcat tgctaaattt 14040 ttcaatagta tcgaaaacag aatatcctaa accatataat atatattcag gaacactcaa 14100 actaaatgtc caggattctc ctaaatacgt aaactttaat agtgcgaaat cattcaaaaa 14160 tctaccactt atagatagat agatagtaca taaatgcgta tagtagtcta cctatctctt 14220 tattatgaaa accggcatta cgatcatata tgtcgtgata tacctgtgat ccgtttacgt 14280 taaaccataa atacatgggt gatcctataa acatgaattt atttctaatt ctcagagcta 14340 tagttaattg accgtgtaat atttgcttac atgcatactt gatacgatca ttaataagat 14400 ttttatcatt gctcgttatt tcagaatcgt atatataagg agtaccatcg tgattcttac 14460 cagatattat acaaaatact atatataaaa tatattgacc cacgttagta atcatgtaa a 14520 tgtttaacgt tttaaatttt gtattcaatg atccattatc atacgctagc atggtcttat 14580 gatattcatt ctttaaaata taatattgtg ttagccattg cattggggct cctaatggag 14640 attttttatt ctcatccatt ttaggatagg ctttcataaa gtccctaata acttcgtgaa 14700 taatgtttct atgttttcta ctgatgcatg tatttgcttc gattttttta tcccatgttt 14760 catctatcat agatttaaac gcagtaatgc tcgcaacatt aacatcttga accgttggta 14820 caattccgtt ccataaattt ataatgttcg ccatttatat aactcatttt ttgaatatac 14880 ttttaattaa caaaagagtt aagttactca tatggacgcc gtccagtctg aacatcaatc 14940 tttttagcca gagatatcat agccgctctt agagtttcag cgtgattttc caacctaaat 15000 agaacttcat cgttgcgttt acaacacttt tctatttgtt caaactttgt tgttacatta 15060 gtaatctttt tttccaaatt agttagccgt tgtttgagag tttcctcatt gtcgtcttca 15120 tcggctttaa caattgcttc gcgtttagcc tctggctttt tagcagccgt tgtagaaaaa 15180 aattcagttg ctggaattgc aagatcgtca tctccgggga aaagagttcc gtccatttaa 15240 agtacagatt ttagaaactg acactctgcg ttatttatat ttggtacaac acatggatta 15300 taaatattga tgttaataac atcagaaaat gtaaagtcta tacattgttg c atcgtgtta 15360 aattttctaa tggatctagt attattgggt ccaacttctg cctgaaatcc aaatatggaa 15420 gcggatacaa aaccgtttcc tggataaacc acacatctcc acttttgctt tacatcagaa 15480 attgtgtcgt tgacatcttg aactctccta tctaatgccg gtgttccacc tatagatttt 15540 gaatattcga atgctgcatg agtagcatta aattccttaa tattgccata attttcatat 15600 attgagtaac cctggataaa aagtaaacac accgcagccg tagctaccac aataaaaaaa 15660 attgatagag agttcattta taatctatta gaagctgaca aaattttttt acacgcatca 15720 gacaatgctt taataaatag ttcaacatct acttttgtca tatcgaaccg atggtatgat 15780 tctaacctag aattacatcc gaaaaagttg actatgttca tagtcattaa gtcattaaca 15840 aacaacattc cagactctgg attataagac gatactgttt cgtcacaatt acctacctta 15900 atcatgtgat tatgaatatt ggctattaga gcaccttcta agaaatctat aatatctttg 15960 aaacacgatt taaaatcaaa ccacgaatat acttctacga agaaagttag tttacccata 16020 ggagaaataa ctataaatgg agatctaaat acaaaatccg gatctatgat agttttaaca 16080 ttattatatt ctctattaaa tacctccaca tctaaaaatg ttaattttga aactatgtct 16140 tcgtttatta ccgtacctga actaaacgct ataagctcta ttgt ttgaga actctttaaa 16200 cgatattctt gaaatacatg taacaaagtt tcctttaact cggtcggttt atctaccata 16260 gttacagaat ttgtatcctt atctataata taataatcaa aatcgtataa agttatataa 16320 ttatcgcgtt cagattggga tcttttcaaa tagactaaaa accccatttc tctagtaagt 16380 atcttatgta tatgtttgta aaatatcttc atggtgggaa tatgctctac cgcagttagc 16440 cattcctcat tgacagcggt agatgtatta gacaaaacta ttccaatgtt taacaagggc 16500 cattttacga gattattaaa tccttgtttg ataaatgtag ccaatgaggg ttcgagttca 16560 acgacgattg aattctcttc ccgcggatgc tgcatgatga acgacgggat gttgttcgat 16620 tgatttggaa ttctttttcg actttttgtt tatattaaat attttaaaat ttatagcgga 16680 tagcaattca tgtaccacgg ataatgtaga cgcgtattgc gcatcgatat ctttattatt 16740 agataaattt atcaataaat gtgagaagtt tgcctcgtta aggtcttcca tttaaatatt 16800 atataaacat ttgtgtttgt atcttattcg tcttttatgg aatagttttt tactagtaaa 16860 gctgcaatta cacactttgt ccgtaaaaca taaatataaa caccagcttt tatcaatcgt 16920 tccaaaaagt cgacggcgga catttttaac atggcatcta ttttaaatac acttaggttt 16980 ttggaaaaaa catcatttta taattgtaac gattcaa taa ctaaagaaaa gattaagatt 17040 aaacataagg gaatgtcatt tgtattttat aagccaaagc attctaccgt tgttaaatac 17100 ttgtctggag gaggtatata tcatgatgat ttggttgtat tggggaaggt aacaattaat 17160 gatctaaaga tgatgctatt ttacatggat ttatcatatc atggagtgac aagtagtgga 17220 acaatttaca aattgggatc gtctatcgat agactttctc taaataggac tattgttaca 17280 aaagttaata attataatta tgatacattt tttgacgatg atgattgatc gctattgcac 17340 aattttgttt ttttactttc taatatagcg tttagattct ttttcatgtg cgaatattga 17400 tttactaaaa tatctatgtt taacttttgt tctataacgt ccttatcggc ggtatcggta 17460 catatacgta attcaccttc acaaaatacg gagtcttcga taataatagc caatcgatta 17520 ttggatctag ctgtctgtat catattcaac atgtttaata tatcctttcg tttccccttt 17580 acaggcatcg atcgtagcat attttccgcg tctgagatgg aaatgttaaa actacaaaaa 17640 tgcgtaatgt tagcccgtcc taatattggt acgtgtctat aagtttggca tagtagaata 17700 atagacgtgt ttaaatgcct tccaaagttt aagaattcta ttagagtatt gcattttgat 17760 agtttatcgc ctacatcatc aaaaataagt aaaaagtgtg ctgatttttt atgattttgt 17820 gcgacagcaa tacatttttc tatgttactt ttagttcgta tcagattata ttctagagat 17880 tcctgactac taacgaaatt aatatgattt ggccaaatgt atccatcata atctggatta 17940 taaacgggtg taaacaagaa tacatgttta tattttttaa ctagtgtaga aaacagagat 18000 agtaaataga tagtttttcc agatccagat cctcccgtta aaaccattct aaacggcatt 18060 tttaataaat tttctcttga aaattgtttt tcttggaaac aattcataat tatatttaca 18120 gttactaaat taatttgata ataaatcaaa atatggaaaa ctaaggtcgt tagtagggag 18180 gagaacaaag aaggcacatc gtgacataaa taacatttat tatcatgatg acaccagaaa 18240 acgacgaaga gcagacatct gtgttctccg ctactgttta cagagacaaa attcagggaa 18300 agaataaacg caaacgcgtg attggtctat gtattagaat atctatggtt atttcactac 18360 tatctatgat taccatgtcc gcgtttctca tagtgcgcct aaatcaatgc atgtctgcta 18420 acgaggctgc tattactgac gccgctgttg ccgttgctgc tgcatcatct actcatagaa 18480 aggttgcgtc tagcactacg caatatgatc acaaagaaag ctgtaatggt ttatattacc 18540 agggttcttg ttatatatta cattcagact accagttatt ctcggatgct aaagcaaatt 18600 gcactgcgga atcatcaaca ctacccaata aatccgatgt cttgactacc tggctcattg 18660 attatgttaa ggatacatgg gg atctgatg gtaatccaat tacaaaaact acatccgatt 18720 atcaagattc tgatgtatca caagaagtta gaaagtattt ttgtgttaaa acaatgaact 18780 aatatttatt tttgtacatt aataaatgaa atcgcttaat agacaaactg taagtaggtt 18840 taagaagttg tcggtgccgg tcgctataat gatgatactc tcaaccatta ttagtggcat 18900 aggaacattt ctgcattaca aagaagaact gatgcctagt gcttgcgcca atggatggat 18960 acaatacgat aaacattgtt atttagatac taacattaaa atgtctacag ataatgcggt 19020 ttatcagtgt cgtaaattac gagccagatt gcctagaccg gatactagac atctgagagt 19080 attgtttagt attttttata aagattattg ggtaagttta aaaaagacca atgataaatg 19140 gttagatatt aataatgata aagatataga tattagtaaa ttaacaaatt ttaaacaact 19200 aaacagtacg acggatgctg aagcgtgtta tatatacaag tctggaaaac tggttaaaac 19260 agtatgtaaa agtactcaat ctgtactatg tgttaaaaaa ttctacaagt gacaacaaaa 19320 aatgaattaa taataagtcg ttaacgtacg ccgccatgga cgccgcgttt gttattactc 19380 caatgggtgt gttgactata acagatacat tgtatgatga tctcgatatc tcaatcatgg 19440 actttatagg accatacatt ataggtaaca taaaaactgt ccaaatagat gtacgggata 19500 taaaatattc cgaca tgcaa aaatgctact ttagctataa gggtaaaata gttcctcagg 19560 attctaatga tttggctaga ttcaacattt atagcatttg tgccgcatac agatcaaaaa 19620 ataccatcat catagcatgc gactatgata tcatgttaga tatagaagat aaacatcagc 19680 cattttatct attcccatct attgatgttt ttaacgctac aatcatagaa gcgtataacc 19740 tgtatacagc tggagattat catctaatca tcaatccttc agataatctg aaaatgaaat 19800 tgtcgtttaa ttcttcattc tgcatatcag acggcaatgg atggatcata attgatggga 19860 aatgcaatag taatttttta tcataaaagt tgtaaagtaa ataataaaac aataaatatt 19920 gaactagtag tacgtatatt gagcaatcag aaatgatgct ggtacctctt atcacggtga 19980 ccgtagttgc gggaacaata ttagtatgtt atatattata tatttgtagg aaaaagatac 20040 gtactgtcta taatgacaat aaaattatca tgacaaaatt aaaaaagata aagagttcta 20100 attccagcaa atctagtaaa tcaactgata gcgaatcaga ctgggaggat cactgtagtg 20160 ctatggaaca aaacaatgac gtagataata tttctaggaa tgagatattg gacgatgata 20220 gcttcgctgg tagtttaata tgggataacg aatccaatgt tatggcgcct agcacagaac 20280 acatttacga tagtgttgct ggaagcacgc tgctaataaa taatgatcgt aatgaacaga 20340 ctatttat ca gaacactaca gtagtactta atgaagatac caaacagaat cctaactatt 20400 catccaatcc tttcgtaaat tataataaaa ccagtatttg tagcaagtca aatccgttca 20460 ttacagaact caacaataaa tttagtgaga ataatccgtt tagacgagca catagcgatg 20520 attatcttaa taagcaagaa caagatcatg aacacgatga tatagaatca ttggtgtgat 20580 tagtttcctt tttataaaat tgaagtaata tttagtatta ttgctgccgt cacgttgtac 20640 aaatggagat attccctgta ttcggcattt ctaaaattag caattttatt gctaataatg 20700 actgtagata ttatatagat acagaacatc aaaaaattat atctgatgag atcaatagac 20760 agatggatga aacggtactt cttaccaaca tcttaagcgt agaagttgta aatgacaatg 20820 agatgtacca tcttattcct catagattat cgacgattat actctgtatt agttctgtcg 20880 gaggatgtgt tatctctata gataatgacg tcaatggcaa aaatattcta acctttccca 20940 ttgatcatgc tgtaatcata tccccactga gtaaatgtgt cgtagttagc aagggtccta 21000 caaccatatt ggttgttaaa gcggatatac ctagcaaacg attggtaaca tcgtttacaa 21060 acgacatact gtatgtaaac aatctatcac tgattaatta ttcgccgttg tctgtattca 21120 ttattagacg agttaccgac tatttggata gacacatatg cgatcagata tttgcgaata 21180 ataagtggta ttccattata accatcgaca ataagcagtt tcctattcca tcaaactgta 21240 taggtatgtc ctctgccaag tacataaatt ctagcatcga gcaagatact ttaatacatg 21300 tttgtaacct cgagcatcca ttcgacttag tatacaaaaa aatgcagtcg tacaattctg 21360 tacctatcaa ggaacaaata ttgtacggta gaattgataa tataaatatg agcattagta 21420 tttctgtgga ttaatagatt tctagtatgg ggatcattaa tcatctctaa tctctaaata 21480 cctcataaaa cgaaaaaaaa gctattatca aatactgtac ggaatggatt cattctcttc 21540 tctttttatg aaactctgtt gtatatctac tgataaaact ggaagcaaaa aatctgataa 21600 aaagaataag aataagatca aggattatta taaaataaca atagttcctg gttcctcttc 21660 cacgtctact agctcgtggt attatacaca tgcctagtaa tagtctcttt gcgttgacgg 21720 aaagcagact agaaataaca ggctaaaatg ttcagacacc ataatagttc ccaacccaga 21780 taataacaga gtaccatcaa cacattcctt taaactcaat cccaaaccca aaaccgttaa 21840 aatgtatccg gccaattgat agtagataat gaggtgtaca gcgcatgatg atttacacag 21900 taaccaaaat gaaaatactt tagtaattat aagaaatata gatggtaacg tcatcatcaa 21960 caatccaata atatgccgga gagtaaacat tgacggataa aacaaaaatg ctccgcata a 22020 ctctatcatg gcaataacac aaccaaatac ttgtaagatt cctaaattag tagaaaatac 22080 aacggatatc gatgtataag tgatctcgag aaataataag aataaagtaa tgcccgtaaa 22140 gataaacatc aacattgttt ggtaatcatt aaaccaatta gtatgaagtt gaactaattt 22200 cacagtagat tttattccag tattatcccc gcatgtataa gtacctggta agatatcttt 22260 atattccata atcaatgaga catcactatc tgataacgaa tgaagtctag cactagtatg 22320 ccatttactt aatattgtcg tcttggaagt tttattataa gttaaaatat catggttatc 22380 caatttccat ctaatatact ttgtcggatt atctatagta cacggaataa tgatggtatc 22440 attacatgct gtatactcta tggtctttgt agttgttata acaaccaacg tatagaggta 22500 tatcaacgat attctaactc ttgacatttt ttatttattt aaaatgatac ctttgttatt 22560 tattttattc tattttgcta acggtattga atggcataag tttgaaacga gtgaagaaat 22620 aatttctact tacttattag acgacgtatt atacacgggt gttaatgggg cggtatacac 22680 attttcaaat aataaactaa acaaaactgg tttaactaat aataattata taacaacatc 22740 tataaaagta gaggatgcgg aaccaataac ggaaatccca aatgttggaa aatagacggt 22800 tcagacgacc caaaacatag aggtagagga tacgctcctt atcaaaatag c aaagtaacg 22860 ataatcagtc acaacggatg tgtactatct gacataaaca tatcaaaaga aggaattaaa 22920 cgatggagaa gatttgacgg accatgtggt tatgatttat acacggcgga taacgtaatt 22980 ccaaaagatg gtttacgagg agcattcgtc gataaagatg gtacttatga caaagtttac 23040 attcttttca ctgatactat cggctcaaag agaattgtca aaattccgta tatagcacaa 23100 atgtgcctaa acgacgaagg tggtccatca tcattgtcta gtcatagatg gtcgacgttt 23160 ctcaaagtcg aattagaatg tgatatcgac ggaagaagtt atagacaaat tattcattct 23220 agaactataa aaacagataa tgatacgata ctatatgtat tcttcgatag tccttattcc 23280 aagtccgcat tatgtaccta ttctatgaat accattaaac aatctttttc tacgtcaaaa 23340 ttggaaggat atacaaagca attgccgtct ccagctcctg gtatatgttt accagctgga 23400 aaagttgttc cacataccac gtttgaagtc atagaaaaat ataatgtact agatgatatt 23460 ataaagcctt tatctaacca acctatcttc gaaggaccgt ctggtgttaa atggttcgat 23520 ataaaggaga aggaaaatga acatcgggaa tatagaatat acttcataaa agaaaattct 23580 atatattcgt tcgatacaaa atctaaacaa actcgtagct cgcaagtcga tgcgcgacta 23640 ttttcagtaa tggtaacttc gaaaccgtta tttatagcag atat agggat aggagtagga 23700 atgccacaaa tgaaaaaaat acttaaaatg taatcttaat cgagtacacc gcacgacaat 23760 gaacaaacat aagacagatt atgctggtta tgcttgctgc gtaatatgcg gtctaattgt 23820 tggaattatt tttacagcga cactattaaa agttgtagaa cgtaaattag ttcatacacc 23880 atcaatagat aaaacgataa aagatgcata tattagagaa gattgtccta ctgactggat 23940 aagctataat aataaatgta tccatttatc tactgatcga aaaacctggg aggaaggacg 24000 taatgcatgc aaagctctaa atccaaattc ggatctaatt aagatagaga ctccaaacga 24060 gttaagtttt ttaagaagca ttagacgcgg atattgggta ggagaatccg aaatattaaa 24120 ccagacaacc ccatataatt ttatagctaa aaatgccacg aagaatggaa ctaaaaaacg 24180 gaaatatatt tgtagtacaa cgaatactcc caaactacat ttttatcata ccactacttc 24240 ggttagatgt tttagaaaaa aataaatatc gccgtaccgt tcttgttttt ataaaaataa 24300 caattaacaa ttatcaaatt ttttctttaa tattttacgt ggttgaccat tcttggtggt 24360 aaaataatct cttagtgttg gaatggaatg ctgtttaatg tttccgcact catcgtatat 24420 tttgacgtat gcagtcacat cgtttacgca atagtcagac tgtagttcta tcatgcttcc 24480 tacatcagaa ggaggaacag ttttaaagtc tcttggt ttt aatctattgc cattagtttt 24540 catgaaatcc tttgttttat ccacttcaca ttttaaataa atgtccacta tacattcttc 24600 tgttaatttt actagatcgt catgggtcat agaatttata ggttccgtag tccatggatc 24660 caaactagca aacttcgcgt atacggtatc gcgattagtg tatacaccaa ctgtatgaaa 24720 attaagaaaa cagtttaata aatcaacaga aatatttaat cctccgtttg atacagatgc 24780 gccatattta tggatttcgg attcacacgt tgtttgtctg aggtgttcgt ctagtgttgc 24840 ttctacgtaa acttcgattc ccatatattc tttattgtca gaatcgcata ccgatttatc 24900 atcatacact gtttgaaaac taaatggtat acacatcaaa ataataaata ataacgagta 24960 cattctgcaa tattgttatc gtaattggaa aaatagtgtt cgagtgagtt ggattatgtg 25020 agtattggat tgtatatttt attttatatt ttatattttg tagtaagaat agaatgctaa 25080 tgtcaagttt attccaatag atgtcttatt aaaaaacata tataataaat aacaatggct 25140 gaatggcata aaattatcga ggatatctca aaaaataata agttcgagga tgccgccatc 25200 gttgattaca agactacaaa gaatgttcta gctgctattc ctaacagaac atttgccaag 25260 attaatcctc tcatcactaa tcgtaatatt ctaaaacctc ttattggtca gaaatattgt 25320 attgtatata ctaactctct aatggatgag aacacgtatg ctatggagtt gcttactggg 25380 tacgcccctg tatctccgat cgttatagcg agaactcata ccgcacttat atttttgatg 25440 ggtaagccaa caacatccag acgtgacgtg tatagaacgt gtagagatca cgctacccgt 25500 gtacgtgcaa ctggtaatta aaataaaaag taatattcat atgtagtgtc aattttaaat 25560 gatgatgatg aaatggataa tatccatatt gacgatgtca ataatgccgg tattggcata 25620 cagttcatcg atttttagat ttcattcaga ggatgtggaa ttatgttatg ggcatttgta 25680 ttttgatagg atctataatg tagtaaatat aaaatataat ccgcatattc catatagata 25740 taattttatt aatcgcacgt taaccgtaga tgaactagac gataatgtct tttttacaca 25800 tggttatttt ttaaaacaca aatatggttc acttaatcct agtttgattg tctcattatc 25860 aggaaactta aaatataatg atatacaatg ctcagtaaat gtatcgtgtc tcattaaaaa 25920 tttggcaacg agtacatcta ctatattaac atctaaacat aagacttatt ctctacatcg 25980 gtccacgtgt attactataa taggatacga ttctattata tggtataaag atataaatga 26040 catctatgat tttactgcaa tatgtatgct aatagcgtct acattgatag tgaccatata 26100 cgtgtttaaa aaaataaaaa tgaactctta attatgctat gctattagaa atggataaaa 26160 tcaaaattac ggttgattca aa aattggta atgttgttac catatcgtat aacttggaaa 26220 agataactat tgatgtcaca cctaaaaaga aaaaagaaaa ggatgtatta ttagcgcaat 26280 cagttgctgt cgaagaggca aaagatgtca aggtagaaga aaaaaatatt atcgatattg 26340 aagatgacga tgatatggat gtagaaagcg cataatacga tctataaaaa taagtatata 26400 aatacttttt atttactgta ctcttactgt gtagtggtga taccctactc gattattttt 26460 ttaaaaaaaa atacttattc tgattcttct agccatttcc gtgttcgttc gaatgccaca 26520 tcgacgttaa agatagggga gtagttgaaa tctagttctg cattgttggt acgcacctca 26580 aatgtagtgt tggatatctt caacgtatag ttgttgagta gtgatggttt tctaaataga 26640 attctcttca tatcattctt gcacgcgtac atttttagca tccatcttgg aatcctagat 26700 ccttgttcta ttcccaatgg tttcatcaat agaagattaa acatatcgta cgaacacgat 26760 ggagagtaat cgtagcaaaa gtaagcattt cctttaatct cagatcccgg atactggata 26820 tattttgcag ccaacacgtg catccatgca gcatttccta catatacccg gctatgtacc 26880 gcgttatcat cgactgtacg atacataatg ttaccgtgtt gcttacattg ctcgtaaaag 26940 actttcatca atttgtctcc ttctccgtaa attccagtgg gtcttaggca acaagtatac 27000 aattttgctc cattc atgat tacggaatta ttggctttca taaccagttg ctcggccata 27060 cgtttacttt ttgcgtatac atgtcctggt gatatatcat aaagggtatg ctcatggccg 27120 atgaatggat caccgtgttt attgggtcct attgcttcca tgctactagt atagatcaaa 27180 tacttgattc ctaggtccac acaagctgcc aatatagtct gtgttccata atagtttact 27240 ttcatgattt cattatcggt gtattttcca aatacatcca ctagagcagc tgtatgaata 27300 atcagattta ccccatctag cgcttctctt accttatcaa agtcgtttat atcacattgt 27360 atatagttta taaccttaac tttcgaggtt attggttgtg gatcttctac aatatctatg 27420 actctgattt cttgaacatc atctgcacta attaacagtt ttactatata cctgcctaga 27480 aatccggcac caccagtaac cgcgtacacg gccattgctg ccactcataa tatcagacta 27540 cttattctat tttactaaat aatggctgtt tgtataatag accacgataa tatcagagga 27600 gttatttact ttgaaccagt ccatggaaaa gataaagtta ttggattaaa atccggaacg 27660 tatagtttga taattcatcg ttacggagat attagtcaag gatgtgattc cataggcagt 27720 ccagaaatat ttatcggtaa catctttgta aacagatatg gtgtagcata tgtttattta 27780 gatacagatg taaatatatc tacaattatt ggaaaggcgt tatctatttc aaaaaatgat 27840 cagagattag cgtgtggagt tattggtatt tcttacataa atgaaaagat aatacatttt 27900 cttacaatta acgagaatgg cgtttgatat atcagttaat gcgtctaaaa caataaatgc 27960 attagtttac ttttctactc agcaaaataa attagtcata cgtaatgaag ttaatgatac 28020 acactacact gtcgaatttg atagggacaa agtagttgac acgtttattt catataata g 28080 acataatgac tccatagaga taagaggggt gcttccagag gaaactaata ttggttgcgc 28140 ggttaatacg ccggttagta tgacttactt gtataataag tatagtttta aactgatttt 28200 agcagaatat ataagacaca gaaatactat atccggcaat atttattcgg cattgatgac 28260 actagatgat ttggctatta aacagtatgg agacattgat ctattattta atgagaaact 28320 taaagtagac tccgattcgg gactatttga ctttgtcaac tttgtaaagg atatgatatg 28380 ttgtgattct agaatagtag tagctctatc tagtctagta tctaaacatt gggaattgac 28440 aaataaaaaa tataggtgta tggcattagc cgaacatata tctgatagta ttccaatatc 28500 tgagctatct agactacgat acaatctatg taagtatcta cgcgggcaca ctgagagcat 28560 agaggatgaa tttgattatt ttgaagacga tgattcgtct acatgttctg ccgtaaccga 28620 cagggaaacg gatgtataat tttttttata gcgtgaagga tatgataaaa aatataattg 28680 ttgtatttat cccattccaa tcaccttata tgattctgta acacaatgaa ggagtcttat 28740 agatgtatag aggtcagata ctggtttgat aaactgttta ttccacataa gtatgtttga 28800 ctttatggtt agacccgcat actttaacaa atcactgaaa attggagtta ggtattgacc 28860 tctcagaatc agttgccgtt ctggaacatt aaatgtattt tttatgatat a ctccaacgc 28920 atttatgtgg gcatacaaca agtcattact aatggagtat tccaagagaa gagatttcaa 28980 cagactgttt atgaactcga atgccgcctc attgtcgctt atattgatga tgtcgaattc 29040 tcccaatatc atcaccgatg agtagctcat cttgttatcg ggatccaagt tttctaaaga 29100 tgtcattaaa ccctcgatca tgaatggatt tatcatcatc gtttttatgt tggacatgag 29160 cttagtccgt ttgtccacat ctatagacga cgatttctga attatttcat atatccctct 29220 ctttaactcc aggaacttgt caggatggtc tactttaata tgttctcgtc taagagatga 29280 aaatctttgg atggttgcac gcgacttttc tctaaaggat cctctcttaa atgaatccat 29340 cttatccttg gacaagatgg acagtctatt ttccttagat ggtttaatat ttttgttacc 29400 catgatctat aaaggtagac ctaatcgtct cggatgacca tatatttatt ttcagtttta 29460 ttatacgcat aaattgtaaa aaatatgtta ggtttacaaa aatgtctcgt ggggcattaa 29520 tcgtttttga aggattggac aaatctggaa aaacaacaca atgtatgaac atcatggaat 29580 ctataccggc aaacacgata aaatatctta actttcctca gagatccact gtcactggaa 29640 agatgataga tgactatcta actcgtaaaa aaacctataa tgatcatata gttaatctat 29700 tattttgtgc aaatagatgg gagtttgcat cttttataca agaa caacta gaacagggaa 29760 ttactttaat agttgataga tacgcattct ctggagtagc gtatgccgcc gctaaaggcg 29820 cgtcaatgac tctcagtaag agttatgaat ctggattgcc taaacccgac ttagttatat 29880 tcttggaatc tggtagcaaa gaaattaata gaaacgtcgg cgaggaaatt tatgaagatg 29940 ttacattcca acaaaaggta ttacaagaat ataaaaaaat gattgaagaa ggagatattc 30000 attggcaaat tatttcttct gaattcgagg aagatgtaaa gaaggagttg attaagaata 30060 tagttataga ggctatacac acggttactg gaccagtggg gcaactgtgg atgtaatagt 30120 gaaattacat tttttataaa tggatgaagc atattactct ggcaacttgg aatcagtact 30180 cggatacgtg tccgatatgc ataccgaact cgcatcaata tctcaattag ttattgccaa 30240 gatagaaact atagataatg atatattaaa caaggacatt gtaaatttta tcatgtgtag 30300 atcaaacttg gataatccat ttatctcttt cctagatact gtatatacta ttatagatca 30360 agagatctat cagaccgaat tgattaattc attagacgac aatgaaatta tcgattgtat 30420 agttaacaag tttatgagct tttataagga taacctagaa aatatagtag atgctatcat 30480 tactctaaaa tatataatga ataatccaga ttttaaaact acgtatgccg aagtactcgg 30540 ttccagaata gcggatatag atattaaaca agtgata cgt gagaatatac tacaattgtc 30600 taataatatc cgcgaacgat atttgtgaaa atattaaaaa aaaatacttt ttttattaaa 30660 tgacgtcgct tcgcgaattt agaaaattat gctgtgatat atatcacgca tcaggatata 30720 aagaaaaatc taaattaatt agagacttta taacagatag ggatgataaa tatttgatca 30780 ttaagctatt gcttcccgga ttagacgata gaatttataa catgaacgat aaacaaatta 30840 taaaattata tagtataata tttaaacaat ctcaggaaga tatgctacaa gatttaggat 30900 acggatatat aggagacact attaggactt tcttcaaaga gaacacagaa atccgtccac 30960 gagataaaag cattttaact ttagaagaag tggatagttt tttaactacg ttatcatccg 31020 taactaaaga atcgcatcaa ataaaattat tgactgatat cgcatccgtt tgtacatgta 31080 atgatttaaa atgtgtagtc atgcttattg ataaagatct aaaaattaaa gcgggccctc 31140 ggtacgtact taacgctatt agtcctcatg cctatgatgt gtttagaaaa tctaataact 31200 tgaaagagat aatagaaaat gcatctaaac aaaatctaga ctctatatct atttctgtta 31260 tgactccaat taatcccatg ttagcggaat cgtgtgattc tgtcaataag gcgtttaaaa 31320 aatttccatc aggaatgttt gcggaagtca aatacgatgg tgaaagagta caagttcata 31380 aaaataataa cgagtttgcc ttctttagta gaaacatgaa accagtactc tctcataaag 31440 tggattatct caaagaatac ataccgaaag catttaaaaa agctacgtct atcgtattgg 31500 attctgaaat tgttcttgta gacgaacata atgtaccgct cccgtttgga agtttaggta 31560 tacacaaaaa gaaagaatat aaaaactcta acatgtgttt gttcgtgttt gactgtttgt 31620 actttgatgg attcgatatg acggacattc cattgtacga acgaagatct tttctcaaag 31680 atgttatggt tgaaataccc aatagaatag tattctcaga gttgacgaat attagtaacg 31740 agtctcagtt aactgacgta ttggatgatg cactaacgag aaaattagaa ggattggtct 31800 taaaagatat taatggagta tacgaaccgg gaaagagaag atggttaaaa ataaagcgag 31860 actatttgaa cgagggttcc atggcagatt ctgccgattt agtagtacta ggtgcttact 31920 atggtaaagg agcaaagggt ggtatcatgg cagtctttct aatgggttgt tacgacgatg 31980 aatccggtaa atggaagacg gttaccaagt gttcaggaca cgatgataat acgttaaggg 32040 agttgcaaga ccaattaaag atgattaaaa ttaacaagga tcccaaaaaa attccagagt 32100 ggttagtagt taataaaatc tatattcccg attttgtagt agaggatcca aaacaatctc 32160 agatatggga aatttcagga gcagagttta catcttccaa gtcccatacc gcaaatggaa 32220 tatccattag atttcctaga tt tactagga taagagagga taaaacgtgg aaagaatcta 32280 ctcatctaaa cgatttagta aacttgacta aatcttaata gttacataca aattaaaata 32340 acactattta gttggtggtc gccatggatg gtgttattgt atactgtcta aacgcgttag 32400 taaaacatgg cgaggaaata aatcatataa aaaatgattt catgattaaa ccatgttgtg 32460 aaaaagtcaa gaacgttcac attggcggac aatctaaaaa caatacagtg attgcagatt 32520 tgccatatat ggataatgcg gtatccgatg tatgcaattc actgtataaa aagaatgtat 32580 caagaatatc cagatttgct aatttgataa agatagatga cgatgacaag actcctactg 32640 gtgtatataa ttattttaaa cctaaagatg ccattcctgt tattatatcc ataggaaagg 32700 atagagatgt ttgtgaacta ttaatctcat ctgataaagc gtgtgcgtgt atagagttaa 32760 attcatataa agtagccatt cttcccatgg atgtttcctt ttttaccaaa ggaaatgcat 32820 cattgattat tctcctgttt gatttctcta tcgatgcggc acctctctta agaagtgtaa 32880 ccgataataa tgttattata tctagacacc agcgtctaca tgacgagctt ccgagttcca 32940 attggttcaa gttttacata agtataaagt ccgactattg ttctatatta tatatggttg 33000 ttgatggatc tgtgatgcat gcaatagctg ataatagaac ttacgcaaat attagcaaaa 33060 atatattaga caata ctaca attaacgatg agtgtagatg ctgttatttt gaaccacaga 33120 ttaggattct tgatagagat gagatgctca atggatcatc gtgtgatatg aacagacatt 33180 gtattatgat gaatttacct gatgtaggcg aatttggatc tagtatgttg gggaaatatg 33240 aacctgacat gattaagatt gctctttcgg tggctggtat ttggaaagtt ttataggtag 33300 ttgatagaac aaaatacata attttgtaaa aataaatcac tttttatact aatatgacac 33360 gattaccaat acttttgtta ctaatatcat tagtatacgc tacacctttt cctcagacat 33420 ctaaaaaaat aggtgatgat gcaactttat catgtaatcg aaataataca aatgactacg 33480 ttgttatgag tgcttggtat aaggagccca attccattat tcttttagct gctaaaagcg 33540 acgtcttgta ttttgataat tataccaagg ataaaatatc ttacgactct ccatacgatg 33600 atctagttac aactatcaca attaaatcat tgactgctag agatgccggt acttatgtat 33660 gtgcattctt tatgacatcg cctacaaatg acactgataa agtagattat gaagaatact 33720 ccacagagtt gattgtaaat acagatagtg aatcgactat agacataata ctatctggat 33780 ctacacattc accggaaact agttctgaga aacctgatta tatagataat tctaattgct 33840 cgtcggtatt cgaaatcgcg actccggaac caattactga taatgtagaa gatcatacag 33900 acaccgtc ac atacactagt gatagcatta atacagtaag tgcatcatct ggagaatcca 33960 caacagacga gactccggaa ccaattactg ataaagaaga agatcataca gttacagaca 34020 ctgtctcata cactacagta agtacatcat ctggaattgt cactactaaa tcaaccaccg 34080 atgatgcgga tctttatgat acgtacaatg ataatgatac agtaccatca actactgtag 34140 gcggtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa atatttggta 34200 ttaccgcatt aattatattg tcggccgtgg caatattctg tattacatat tatatatata 34260 ataaacgttc acgtaaatac aaaacagaga acaaagtcta gatttttgac ttacataaat 34320 gtctgggata gtaaaatcta tcatattgag cgggccatct ggtttaggaa agacagccat 34380 agccaaaaga ctatgggaat atatttggat ttgtggtgtc ccataccact agatttcctc 34440 gtcctatgga acgagaaggt gtcgattacc attacgttaa cagagaggcc atctggaagg 34500 gaatagccgc cggaacatac tgagttttta ggaaatattt acggaacttc taaaactgct 34560 gtgaatacag cggctattaa taatcgtatt tgtgtgatgg atctaaacat cgacggtgtt 34620 agaagtttta aaaatactta cctaatgcct tactcggtgt atataagacc tacctctctt 34680 aaaatggttg agaccaagct tcgttgtaga aacactgaag cggatgatga gattcatcgt 34740 cgtgtgatgt tggcaaaaac tgacatggat gaggcaggtg aagccggtct attcgacact 34800 attatcattg aagatgatgt gaatttagca tatagtaagt taattcagat actacaggac 34860 cgtattagaa tgtattttaa cactaattag agacttaaga cttaaaactt gataattaat 34920 aatataactc gtttttatat gtggctattt caacgtctaa tgtattagtt aaatattaaa 34980 acttaccacg taaaacttaa aatttaaaat gatatttcat tgacagatag atcacacatt 35040 atgaactttc aaggacttgt gttaactgac aattgcaaaa atcaatgggt cgttggacca 35100 ttaataggaa aaggtggatt tggtagtatt tatactacta atgacaataa ttatgtagta 35160 aaaatagagc ccaaagctaa cggatcatta tttaccgaac aggcatttta tactagagta 35220 cttaaaccat ccgttatcga agaatggaaa aaatctcaca atataaagca cgtaggtctt 35280 atcacgtgca aggcatttgg tctatacaaa tccattaatg tggaatatcg attcttggta 35340 attaatagat taggtgcaga tctagatgcg gtgatcagag ccaataataa tagattacca 35400 aaaaggtcgg tgatgttgat cggaatcgaa atcttaaata ccatacaatt tatgcacgag 35460 caaggatatt ctcacggaga tattaaagcg agtaatatag tcttggatca aatagataag 35520 aataaattat atctagtgga ttacggattg gtttctaaat tcatgtctaa tggcgaaca t 35580 gttccattta taagaaatcc aaataaaatg gataacggta ctctagaatt tacacctata 35640 gattcgcata aaggatacgt tgtatctaga cgtggagatc tagaaacact tggatattgt 35700 atgattagat ggttgggagg tatcttgcca tggactaaga tatctgaaac aaagaattgt 35760 gcattagtaa gtgccacaaa acagaaatat gttaacaata ctgcgacttt gttaatgacc 35820 agtttgcaat atgcacctag agaattgctg caatatatta ccatggtaaa ctctttgaca 35880 tattttgagg aacccaatta cgacaagttt cggcacatat taatgcaggg tgtatattat 35940 taagtgtggt gtttggttga tgtaaaattt ttgtcgataa aaattaaaaa ataacttaat 36000 ttattattga tctcgtgtgt acaaccgaaa tcatggcgat gttttacgca cacgctctcg 36060 gtgggtacga cgagaatctt catgcctttc ctggaatatc atcgactgtt gccaatgatg 36120 tcagtttata ataacaagta tgacattgta aaagacaaat atatgtggtg ttacagtcag 36180 gtgaacaaga gatatattgg agcactgctg cctatgtttg agtgcaatga atatctacaa 36240 attggagatc cgatccatga tcaagaagga aatcacatat cgccacaaaa actactatgc 36300 tctaagcgga atcgggtacg agagtctaga cttgtgtttg gaaggagtag ggattcatca 36360 tcacgtactt gaaacagaaa acgctgtata tggaaaagtt caacatgatt a ttctactat 36420 caaagagaag gccaaagaaa tgaatgcact cagttcagga cctatcatcg attaccacgt 36480 ctggatagga gattgtatct gtcaagttac tgctgtggac gtacatggaa aggaaattat 36540 gagaatgaga ttcaaaaagg gtgcggtgct tccgatccca aatctggtaa aagttaaact 36600 tggggagaat gatacagaaa atctttcttc tactatatcg gcggcaccat cgaggtaacc 36660 acctctctgg aagacagtgt gaatcatgta ctcatgaaac gtttggaatc tatacgccat 36720 atgtggtctg ttgtatatga tcattttgat attgtgaatg gtaaagaatg ctgttatgtg 36780 catacgcatt tgtctaatca aaatcttata ccgagtactg taaaaacaaa tttgtacatg 36840 aagactatgg gatcatgcat tcaaatgagt atcttagcga actgaaggaa tcaggtggat 36900 ggagtcccag accagaaatg caggaatttg aatatccaga tggagtggaa gacactgaat 36960 caattgagag attggtagag gagttcttca atagatcaga acttcaggct ggtaaatcta 37020 ttaatgttaa acatacatct gtttcagcta agcaactaag aacacgtata ctctcatctt 37080 ttgccaacac agagggtgga tatttgttca ttggagttga taataataca cacaaagtat 37140 ttggattcac ggtgggttac gactacctca gactgataga gaatgatata gaaaagcata 37200 tcaaaagact ttgtgttgtg tatttctgtg agaagaaaga ggac atcaag tacacgtgtc 37260 gattcatcaa ggtatataaa cctggggatg aggctacctc gacatacgtg tgcgctatca 37320 aagtggaaag atgctgttgt gctgtgtttg cagattggcc agaatcatgg tatcaagaag 37380 tattctccag atgaataggt gtcacatata aaattttaat taatgtaact atagagaaca 37440 aataataggt tgtaatatca tatagacaat aactaacaat taattagtaa ctgttatctc 37500 tttttaacta actaactata cctattaata catcgtaatt atagttctta acatctatta 37560 atcattgatt cgcttcttta attttttata aaccaacatt gttaattgaa aagggataac 37620 atgttacaga atataaatta tatatggatt ttttttaaaa aggaaatact tgactggagt 37680 gtatatttat ctcttcatta tatagcacgc gtgttttcca atttttccac atcccatata 37740 atacaggatt ataatctcgt tcgaacatac gagaaagtgg ataaaacaat agttgatttt 37800 ttatctaggt tgccaaattt attccatatt ttagaatatg gggaaaatat tctacatatt 37860 tattctatgg atgatgctaa tacgaatatt ataatttttt ttctagatag agtattaaat 37920 attaataaga acgggtcatt tatacacaat ctcaggttat catcatccat taatataaaa 37980 gaatatgtat atcaattagt taataatgat catccagata ataggataag actaatgctt 38040 gaaaatggac gtagaacaag acattttttg tcctata tat cagatacagt taatatctat 38100 atatgtattt tatatagatg ccgaagacag ttacggttgt acattattac atagatgtat 38160 atatcactat aagaaatcag aatcagaatc agaatcatac aatgaattaa ttaagatatt 38220 gttaaataat ggatcagatg tagataaaaa agatacgtac ggaaacacac cttttatcct 38280 attatgtaaa cacgatatca acaacgtgga attgtttgag atatgtttag agaatgctaa 38340 tatagactct gtagacttta atagatatac acctcttcat tatgtctcat gtcgtaataa 38400 atatgatttt gtaaagttat taatttctaa aggagcaaat gttaatgcgc gtaataaatt 38460 cggaactact ccattttatt gtggaattat acacggtatc tcgcttataa aactatattt 38520 ggaatcagac acagagttag aaatagataa tgaacatata gttcgtcatt taataatttt 38580 tgatgctgtt gaatctttag attatctatt atccagagga gttattgata ttaactatcg 38640 tactatttac gacgctgtca gttataatgc gtataatacg ttggtctatc tattaaacag 38700 aaatggtgat tttgagacga ttactactag tggatgtaca tgtatttcgg aagcagtcgc 38760 aaacaacaac aaaataataa tggaagtact attgtctaaa cgaccatctt tgaaaattat 38820 gatacagtct atgatagcaa ttactaaaca taaacagcat aatgcagatt tattgaaaat 38880 gtgtataaaa tatactgcgt gtatgaccga ttatgatact cttatagatg tacaatcact 38940 acagcaatat aaatggtata ttttaagatg tttcgatgaa atagatatca tgaagagatg 39000 ttatataaaa aataaaactg tattccaatt agttttttgt atcaaagaca ttaatacttt 39060 aatgagatac ggtaaacatc cttctttcgt gaagtgcact agtctcgacg tatacggaag 39120 tcgtgtacgt aatatcatag catctattag atatcgtcag agattaatta gtctattatc 39180 caagaagctg gatcctggag ataaatggtc gtgttttcct aacgaaataa aatataacga 39240 taacgaactg tccacatatc taaaaatctt ataaacacta ttaaaatata aaatcacact 39300 acatcattgt ttccttttag tgctcgacag tgtatactat ttttaacgct cataaataaa 39360 aatgaaaacg atttccgttg ttacgttgtt atgcgtacta cctgctgttg tttattcaac 39420 atgtactgta cccactatga ataacgctaa attaacgtct accgaaacat cgtttaataa 39480 taaccagaaa gttacgttta catgtgatca gggatatcat tcttcggatc caaatgctgt 39540 ctgcgaaaca gataaatgga aatacgaaaa tccatgcaaa aaaatgtgca cagtttctga 39600 ttacatctct gaactatata ataaaccgct atacgaagtg aattccacca tgacactaag 39660 ttgcaacggc gaaacaaaat attttcgttg cgaagaaaaa aatggaaata cttcttggaa 39720 tgatactgtt acgtgtccta at gcggaatg tcaacctctt caattagaac acggatcgtg 39780 tcaaccagtt aaagaaaaat actcatttgg ggaatatata actatcaact gtgatgttgg 39840 atatgaggtt attggtgctt cgtacataag ttgtacagct aattcttgga atgttattcc 39900 atcatgtcaa caaaaatgtg atataccgtc tctatctaat ggattaattt ccggatctac 39960 attttctatc ggtggcgtta tacatcttag ttgtaaaagt ggttttatac taacgggatc 40020 tccatcatcc acatgtatcg acggtaaatg gaatcccata ctcccaacat gtgtacgatc 40080 taacgaaaaa tttgatccag tggatgatgg tcccgacgat gagacagatt tgagcaaact 40140 ctcgaaagac gttgtacaat atgaacaaga aatagaatcg ttagaagcaa cttatcatat 40200 aatcatagtg gcgttaacaa ttatgggcgt catattttta atctccgtta tagtattagt 40260 ttgttcctgt gacaaaaata atgaccaata taagttccat aaattgctac cgtgaatata 40320 aatccgttaa aataatgaat aattaataat taataattta ataacaaaca agtatcaaaa 40380 gattaaagac ttatagctag aatcaattga gatgtcttct tcagtggatg ttgatatcta 40440 cgatgccgtt agagcatttt tactcaggca ctattataac aagagattta ttgtgtatgg 40500 aagaagtaac gccatattac ataatatata caggctattt acaagatgcg ccgttatacc 40560 gttcgatgat atagt acgta ctatgccaaa tgaatcacgt gttaaacaat gggtgatgga 40620 tacacttaat ggtataatga tgaatgaacg cgatgtttct gtaagcgttg gcaccggaat 40680 actattcatg gaaatgtttt tcgattacaa taaaaatagt atcaacaatc aactaatgta 40740 tgatataatt aatagcgtat ctataattct agctaatgag agatatagaa gcgcttttaa 40800 cgacgatggt atatacatcc gtagaaatat gattaacaag ttgtacggat acgcatctct 40860 aactactatt ggcacgatcg ctggaggtgt ttgttattat ctgttgatgc atctagttag 40920 tttgtataaa taattatttc aatatactag ttaaaatttt aagattttaa atgtataaaa 40980 aactaataac gtttttattt gtaataggtg cattagcatc ctattcgaat aatgagtaca 41040 ctccgtttaa taaactgagt gtaaaactct atatagatgg agtagataat atagaaaatt 41100 catatactga tgataataat gaattggtgt taaattttaa agagtacaca atttctatta 41160 ttacagagtc atgcgacgtc ggatttgatt ccatagatat agatgttata aacgactata 41220 aaattattga tatgtctact attcaacgca gaggtcacac gtgtagaata tctaccaaat 41280 tatcatgcca ttatgataag tacccttata ttcacaaata tgatggtgat gagcgacaat 41340 attctattac tgcagaggga aaatgctata aaggaataaa atatgaaata agtatgatca 41400 acgatgatac tctattgaga aaacatactc ttaaaattgg atctacttat atatttgatc 41460 gtcatggaca tagtaataca tattattcaa aatatgattt ttaaaaattt aaaatatatt 41520 atcacttcag tgacagtagt caaataacaa acaacaccat gagatatatt ataattctcg 41580 cagttttgtt cattaatagt atacacgcta aaataactag ttataagttt gaatccgtc a 41640 attttgattc caaaattgaa tggactgggg atggtctata caatatatcc cttaaaaatt 41700 atggcatcaa gacgtggcaa acaatgtata caaatgtacc agaaggaaca tacgacatat 41760 ccgcatttcc aaagaatgat ttcgtatctt tctgggttaa atttgaacaa ggcgattata 41820 aagtggaaga gtattgtacg ggaccaccga ctgtaacatt aactgaatac gacgaccatc 41880 cgtatgctac tagaggtagc aaaaagattc ctatttacaa acgcggtgac atgtgtgata 41940 tctacttgtt gtatacggct aacttcacat tcggagattc taaagaacca gtaccatatg 42000 atatcgatga ctacgattgc acgtctacag gttgcagcat agactttgtc acaacagaaa 42060 aagtgtgcgt gacagcacag ggagccacag aagggtttct cgaaaaaatt actccatgga 42120 gttcgaaagt atgtctgaca cctaaaaaga gtgtatatac atgcgcaatt agatccaaag 42180 aagatgttcc caatttcaag gacaaaatgg ccagagttat caagagaaaa tttaactaaa 42240 tttctcggta gcacatcaaa tgatgttacc acttttctta gcatgcttaa cttgactaaa 42300 tattcataac taatttttat taatgataca aaaacgaaat aaaactgcat attatacact 42360 ggttaacgcc cttataggct ctaaccattt tcaagatgag gtccctgatt atagtccttc 42420 tgttcccctc tatcatctac tccatgtcta ttagacgatg tgagaagact g aagaggaaa 42480 catggggatt gaaaataggg ttgtgtataa ttgccaaaga tttctatccc gaaagaactg 42540 attgcagtgt tcatctccca actgcaagtg aaggcaatgg attcagggat atacgaaaca 42600 ccgataaatt ataaaaaaag caatgtgtcc gctgtttccg ttaataatac tattttcgta 42660 actggcggat tattcataaa taactctaat agcacgatcg tggttaacaa tatggaaaaa 42720 cttgacattt ataaagacaa acaatggtcg attatagaaa tgcctatggc tagggtatat 42780 cacggcatcg actcgacatt tggaatgtta tattttgccg gaggtctatc cgttaccgaa 42840 caatatggta atttagagaa aaacaacgag atatcttgtt acaatcctag aacgaataag 42900 tggtttgata tttcatatac tatttataag atatccatat catcattgtg taaactaaat 42960 aacgtcttct atgtatttag taaggacatt ggatatgtgg aaaagtatga tggtctcccc 43020 gctataaagg cattatcaac ttctccttat tgattgaaaa tgaaaatata aatagttttt 43080 atgtatagca gtattaccct atagttttat tgcttactac taacatggat acagatacag 43140 atgttacaaa tgtagaagat atcatgaatg aaatagatag agagaaagaa gaaatactaa 43200 aaaatgtaga aattgaaaat aataaaaaca ttaacaagaa tcatcccaat gaatatatta 43260 gagaagcact cgttattaat acaagtagta atagtgattc catt gataaa gaagttatag 43320 aatgtatcag tcacgatgta ggaatataga tcatatctac taatttttat aatcaataca 43380 aaacataaaa aacaactcgt tattacatag caggcatgga atccttcaag tattgttttg 43440 ataacgatgg caagaaatgg attatcggaa atactttata ttctggtaat tcaatactct 43500 ataaggtcag aaaaaatttc actagttcgt tctacaatta cgtaatgaag atagatcaca 43560 aatcacacaa gccattgttg tctgaaatac gattctatat atctgtattg gatcctttga 43620 ctatcgacaa ctggacacgg gaacgtggta taaagtattt ggctattcca gatctgtatg 43680 gaattggaga aaccgatgat tatatgttct tcgttataaa gaatttggga agagtattcg 43740 ccccaaagga tactgaatca gtcttcgaag catgcgtcac tatgataaac acgttagagt 43800 ttatacactc tcgaggattt acccatggaa aaatagaacc gaggaatata ctgattagaa 43860 ataaacgtct ttcactaatt gactattcta gaactaacaa actatacaag agtggaaact 43920 cacatataga ttacaacgag gacatgataa cttcaggaaa tatcaattat atgtgtgtag 43980 acaatcatct tggagcaaca gtttcaaaac gaggagattt agaaatgttg ggatattgca 44040 tgatagaatg gttcggtggc aaacttccat ggaaaaacga aagtagtata aaagtaataa 44100 aacaaaaaaa agaatataaa aaatttatag ctacttt ctt tgaggactgt tttcctgaag 44160 gaaatgaacc tctggaatta gttagatata tagaattagt atacacgtta gattattctc 44220 aaactcctaa ttatgacaga ctacgtagac tgtttataca agattgaaat attctttttt 44280 tatagagtgt ggtagtgtta cggatatcta atattaatat tagactatct ctatcgcgct 44340 acacgaccaa tatcgattac tatggatatc ttctatgaaa ggagagaatg tattcatttc 44400 tccagcgtca atctcgtcag tattgacaat actgtattat ggagctaatg gatccactgc 44460 tgaacagcta tcaaaatatg tagaaaagga ggagaacacg gataaggtta gcgctcagaa 44520 tatctcattc aaatccatga ataaagtata tgggcgatat tctgccgtgt ttaaagattc 44580 ctttttgaga aaaattggcg ataagtttca aactgttgac ttcactgatt gtcgcactat 44640 agatgcaatc aacaagtgtg tagatatctt tactgagggg aaaatcaatc cactattgga 44700 tgaacaattg tctcctagca attagtgccg tatactttaa agcaaaatgg ttgacgccat 44760 tcgaaaagga atttaccagt gattatccct tttacgtatc accaacggaa atggtagacg 44820 taagtatgat gtctatgtac ggcgagctat ttaatcacgc atctgtaaaa gaatcattcg 44880 gtaacttttc aatcatagaa ctgccatatg ttggagatac tagtatgatg gtcattcttc 44940 cagacaagat tgatggatta gaatccatag aacaaaatct aacagataca aattttaaga 45000 aatggtgtaa ctctctggaa gctacgttta tcgatgttca cattcccaag tttaaggtaa 45060 caggctcgta taatctggtg gatactctag taaagtcagg actgacagag gtgttcggtt 45120 caactggaga ttatagcaat atgtgtaatt tagatgtgag tgtcgacgct atgatccaca 45180 aaacgtatat agatgtcaat gaagagtata cagaagcagc tgcagcaact tgtgcactgg 45240 tgtcagactg tgcatcaaca attacaaatg agttctgtgt agatcatccg ttcatctatg 45300 tgattaggca tgttgatgga aaaatttttt tcgttggtag atattgctct ccgacaacta 45360 attgttaacc atttttttta aaaaaataga aaaaacatgt ggtattagtg caggtcgtta 45420 ttcttccaat tgcaattggt aagatgacgg ccaactttag tacccacgtc ttttcaccac 45480 agcactgtgg atgtgacaga ctgaccagta ttgatgacgt caaacaatgt ttgactgaat 45540 atatttattg gtcgtcctat gcataccgca acaggcaatg cgctggacaa ttgtattcca 45600 cactcctctc ttttagagat gatgcggaat tagtgttcat cgacattcgc gagctggtaa 45660 aaaatatgcc gtgggatgat gtcaaagatt gtgtagaaat catccgttgt tatataccgg 45720 atgagcaaaa aaccatcatc ggactttgtg catatgctgc tacttactgg ggaggtgaag 45780 accatcccac tagtaacagt ct gaacgcat tgtttgtgat gcttgagatg ctaaattacg 45840 tggattataa catcatattc cggcgtatga attgatgagt tgtacatctt gacattttct 45900 tctttcttct cttctccctt tcccagaaac aaactttttt tacccactat aaaataaaat 45960 gagtatacta cctgttatat ttctttctat atttttttat tcttcattcg ttcagacttt 46020 taacgcgcct gaatgtatcg acaaagggca atattttgca tcattcatgg agttagaaaa 46080 cgagccagta atcttaccat gtcctcaaat aaatacgcta tcatccggat ataatatatt 46140 agatatttta tgggaaaaac gaggagcgga taatgataga attataccga tagataatgg 46200 tagcaatatg ctaattctga acccgacaca atcagactct ggtatttata tatgcattac 46260 cacgaacgaa acctactgtg acatgatgtc gttaaatttg acaatcgtgt ctgtctcaga 46320 atcaaatata gatcttatct cgtatccaca aatagtaaat gagagatcta ctggcgaaat 46380 ggtatgtccc aatattaatg catttattgc tagtaacgta aacgcagata ttatatggag 46440 cgggcatcga cgccttagaa ataagagact taaacaacgg acacctggaa ttattaccat 46500 agaagatgtt agaaaaaatg atgctggtta ttatacatgt gttttagaat atatatacgg 46560 tggcaaaaca tataacgtaa ccagaattgt aaaattagag gtacgggata aaataatacc 46620 ttctactatg caatt accag aaggtgttgt aacttcaata ggtagtaatt tgactattgc 46680 gtgtagagta tcgttgagac ctcccacaac ggatgcagac gtcttttgga taagtaatgg 46740 tatgtattac gaagaagatg atggggacgg agacggtaga ataagtgtag caaataaaat 46800 ctatatgacc gataagagac gtgttattac atcccggtta aacattaatc ctgtcaagga 46860 agaagatgct acaacgttta cgtgtatggc gtttactatt cctagcatca gcaaaacagt 46920 tactgttagt ataacgtgaa tgtatgttgt tacatttcca tgtcaattga gtttataaga 46980 atttttatac attatcttcc aacaaacaat tgacgaacgt attgctatga ttaactccca 47040 cgatactatg catattatta atcattaact tgcagactat acctagtgct attttgacat 47100 actcatgttc ttgtgtaatt gcggtatcta tattattaaa gtacgtaaat ctagctatag 47160 ttttattatt taattttaga taatataccg tctccttatt tttaaaaatt gccacatcct 47220 ttattaaatc atgaatggga atttctatgt catcgttaat atattgtgaa caacaagagc 47280 agatatctat aggaaagggt ggaatgcgat acattgatct atgtagtttt aaaacacacg 47340 cgaactttga agaatttata taaatcattc catcgataca tccttctatg ttgacatgta 47400 tatatccagg aattctttta ttaatgtcag gaaatgtata aactaaaaca ttgcccgaaa 47460 gcggtgcc tc tatctgcgtt atatccgttc ttaacttaca aaatgtaacc aatacctttg 47520 catgacttgt tttgttcggc aacgttagtt taaacttgac gaatggatta attacaatag 47580 catgatccgc gcatctatta agttttttta ctttaacgcc cttgtatgtt tttacagaga 47640 ctttatctaa atttctagtg cttgtatgtg ttataaatat aacgggatat agaactgaat 47700 cacctacctt agatacccaa ttacatttta tcagatccag ataataaaca aattttgtcg 47760 ccctaactaa ttctatattg ttatatattt tacaattggt tatgatatca tgtaataact 47820 tggagtctaa cgcgcatcgt cgtacgttta tacaattgtg atttagtgta gtatatctac 47880 acatgtattt ttccgcacta tagtattctg gactagtgat aaaactatcg ttatatctgt 47940 cttcaatgaa ctcatcgaga tattgctctc tgtcatattc atacacctgc ataaactttc 48000 tagacatctt acaatccgtg ttattttagg atcatattta catatttacg ggtatatcaa 48060 agatgttaga ttagttaatg ggaatcgtct ataataatga atattaaaca attatatgag 48120 gacttttacc acaaagcatc ataaaaatga gtcgtcgtct gatttatgtt ttaaatatca 48180 accgcgaatc aactcataaa atacaagaga atgaaatata tacatatttt agtcattgca 48240 atatagacca tacttctaca gaacttgatt ttgtagttaa aaactatgat ctaaacagac 48300 gacaacctgt aactgggtat actgcactac actgctattt gtataataat tactttacaa 48360 acgatgtact gaagatatta ttaaatcatg gagtggatgt aacgatgaaa accagtagcg 48420 gacgtatgcc tgtttatata ttgcttacta gatgttgtaa tatttcacat gatgtagtga 48480 tagatatgat agacaaagat aaaaaccact tatcgcatag agactattcc aacctactac 48540 tagagtatat aaaatctcgt tacatgttat tgaaggaaga ggatatcgat gagaacatag 48600 tatccacttt attagataag ggaatcgatc ctaactttaa acaagacgga tatacagcgt 48660 tacattatta ttatttgtgt ctcgcacacg tttataaacc aggtgagtgt agaaaaccga 48720 taacgataaa aaaggccaag cgaattattt ctttgtttat acaacatgga gctaatctaa 48780 acgcgttaga taattgtggt aatacaccat tccatttgta tcttagtatt gaaatgtgta 48840 ataatattca tatgactaaa atgctgttga cttttaatcc gaatttcaaa atatgtaata 48900 atcatggatt aacgcctata ctatgttata taacttccga ctacatacaa cacgatattc 48960 ttgttatgtt aatacatcac tatgaaacaa atgttggaga aatgccgata gatgagcgtc 49020 gtataatcgt attcgagttt atcaaaacat attctacacg tccggcagat tcgataactt 49080 atttgatgaa taggtttaaa aatatagata tttatacccg ctatgaagga aagacatta t 49140 tacacgtagc atgtgaatat aataatacac acgtaataga ttatcttata cgtatcaacg 49200 gagatataaa tgcgttaacc gacaataaca aacacgctac acaactcatt atagataaca 49260 aagaaaattc cccatatacc attaattgtt tactgtatat acttagatat attgtagata 49320 agaatgtgat aagatcgttg gtggatcaac ttccatctct acctatcttc gatataaaat 49380 catttgagaa attcatatcc tactgtatac ttttagatga cacattttac aatagacacg 49440 ttaggaatcg caattctaaa acgtatcgat acgcattttc aaaatacatg tcgtttgata 49500 aatacgatgg tataataact aaatgtcata aagaaacaat attgctcaaa ctatccactg 49560 ttctagacac tacactatat gcagttttaa gatgccataa ttcgaaaaag ttaagaagat 49620 acctcaacga gttaaaaaaa tataataacg ataagtcctt taaaatatat tctaatatta 49680 tgaatgagag ataccttaat gtatattata aagatatgta cgtgtcaaag gtatatgata 49740 aactatttcc tgttttcaca gataaaaatt gtctactaac attactacct tcagaaatta 49800 tatacgaaat attatacatg ctgacaatta acgatcttta taatatatcg tatccaccta 49860 ccaaagtata gttgtatttt tctcatgcga tgtgtgtaaa aaaactgata ttatataaat 49920 attttagtgc cgtataatga agatgacgat gaaaatgatg gtacatatat a tttcgtatc 49980 attattgtta ttgctattcc acagttacgc catagacatc gaaaatgaaa tcacagaatt 50040 cttcaataaa atgagagata ctctaccagc taaagactct aaatggttga atccagcatg 50100 tatgttcgga ggcacaatga atgatatagc cgctctagga gagccattca gcgcaaagtg 50160 tcctcctatt gaagacagtc ttttatcgca cagatataaa gactatgtgg ttaaatggga 50220 gaggctagaa aaaaatagac ggcgacaggt ttctaataaa cgtgttaaac atggtgattt 50280 atggatagcc aactatacat ctaaattcag taaccgtagg tatttgtgta ccgtaactac 50340 aaagaatggt gactgtgttc agggtatagt tagatctcat attaaaaaac ctccttcatg 50400 cattccaaaa acatatgaac taggtactca tgataagtat ggcatagact tatactgtgg 50460 aattctttac gcaaaacatt ataataatat aacttggtat aaagataata aggaaattaa 50520 tatcgacgat attaagtatt cacaaacggg aaagaaatta attattcata atccagagtt 50580 agaagatagt ggaagataca actgttacgt tcattacgac gacgttagaa tcaagatgta 50640 aaatacttac ggttataccg tcgcaagacc acaggtttaa actaatacta gatccaaaaa 50700 tcaacgtaac gataggagaa cctgccaata taacatgcac tgctgtgtca acgtcattat 50760 tgattgacga tgtactgatt gaatgggaaa atccatccgg atgg cttata ggattcgatt 50820 ttgatgtata ctctgtttta actagtagag gcggtatcac cgaggcgacc ttgtactttg 50880 aaaatgttac tgaagaatat ataggtaata catataaatg tcgtggacac aactattatt 50940 ttgaaaaaac ccttacaact acagtagtat tggagtaaat acacaatgca tttttatata 51000 cattactgaa taattattat tattatttat atcgtatttg tgctataacg cgactatcta 51060 ggtatttgta tctcaccgat agagaacata taaatgtaga ctctattaaa cagttgtgta 51120 aaatatcaga tcctaataga tgtggatgta cggctttaga aatgagttca ttaaaatatg 51180 tgatatcaac ggaacatatt tatataatta tactattgct gttagtataa ttattgattc 51240 cacggaagaa ctaccaacag ttactccaat tacaacaaca tataattata ctatcgatga 51300 tagcactact gaagaactac aagtgactcc tcatatggat ctccatcgat gatacatgta 51360 ttaaaatact ttccgaataa gtcttttaaa tattgtatta attatgaaaa actatgctat 51420 gcgagtatga tacgatacta gattttatct ctagcgagag atgtcgttag aatcatttat 51480 caacgaatat cgataacatg tgtcatttat acgttaaagt ctgtccgtct tctctattgt 51540 ttagactgtt tgtagaatgc tgtgatataa acaaactagt agacacaaat atttaactca 51600 tgatgaagtt gagaatgata tgctttagct aatataa aaa tatattaatc cactatatat 51660 tctagacttg atttaaaacc gataaactac tactacgtac tgtataagtt aggagcagac 51720 cctaattatg tagatgatag aggtaatact tctgcatcta tatgtccact tatgagaaaa 51780 cgtcatttaa taagatgcat cgtgaaaaga aatttattaa agagttggta aaatatgaaa 51840 ccgaaagtaa ataatatagg aaatacacct ctacataact acgtatctca atatgatatc 51900 actctcattc ctcatccaca acccattaaa aaatggaaat taaagccctc tattagcata 51960 aacggctaca ggtctacctt tacaatggcc tttccttgtg cccagttcag accctgtcat 52020 tgccacgcta ctaaggactc cctgaatacc gtggccgacg tcagacattg tctgactgaa 52080 tacatcctgt gggtttctca tagatggacc catagagaaa gcgcagggtc tctctacagg 52140 cttctcatct ctttcagaac tgatgcaacg gagctctttg gtggtgagtt gaaggattca 52200 cttccgtgga gatcattaaa tgactccatg aaaaccgccg aagaacttcg tgcaatcatt 52260 ggactttgta ctcaatcagc tatcgtctct ggaagagtct tcaacgataa gtatatcgac 52320 atactactta tgctgcgaaa gattctgaac gagaacgact atctcaccct cttggatcat 52380 atccgcactg ctaaatacta aatctccttc atgctctctc actacacttt ttatcatctt 52440 atgaggaata attagcacca gaatagctat ggattgcaca tgtattctat gtcgtctact 52500 ggatgaagat gtgacgtaca aaaaaataaa actagaaatt gaaacgtgtc acaacttatc 52560 aaaacatata gatagacgag gaaacaatgc gctacattgt tacgtctcca ataaatgcga 52620 tacagacatt aagattgttc gactgttact ctctcgcgga gtcgagagac tttgtagaaa 52680 caacgaagga ttaactccgc taggagcata cagtaagcat agatacgtaa aatctcagat 52740 tgtgcatcta ctgatatcca gctattcgaa ttcctctaac gaactcaagt cgaatataaa 52800 tgatttcgac ttacgtctgc taaaatacct aattgtggat aaacggatac gtccgtccaa 52860 gaatacgaat tatgcaatca atggtctcgg attggtggat atatacgtaa cgacgcctaa 52920 tccgagacca gaagtattgc tatggcttct taaatcagaa tgttacagca ccggttacgt 52980 atttcgtacc tgtatgtaca acagtgatat gtgtaagaac tctcttcatt actatatatc 53040 gtctcataga gaatctctat ccaaggatgt aattaaatgt ttgatcgata acaatgtttc 53100 catccaatac tactggtctt gctcaaccat agatatagag attattaata aaggatgtgg 53160 acacgtgtag agtatacgac gtcagcccta tattagaggc gtattatcta aacaagcgat 53220 ttagagtaac cccatataat gtagacatgg aaatcgttaa tcttcttatt gagagacgtc 53280 atactcttgt cgacgtaatg cg tagtatta cttcgtacga ttccagagaa tataaccact 53340 acatcatcga taacattcta aagagattta gacaacagga tgaatccatc gtacaagcca 53400 tactgataaa ctacttacat tacggcgata tggtaagtat acctatcatt caatgcatgt 53460 tggataagac gacggacaac aactttgtta ataataatct cgtcgatgta aacgtcgtaa 53520 ggtttatcgt ggaaaatatg gacacgcggc tgtaaatcac atatctaaca atggccgtct 53580 atgtatgtac ggtctgatat tatcgagatt taataattgc gggtatcact gttatgaaga 53640 tgtatttgat atactaagca agtacatgga tgatatagat atgatcgata actctactat 53700 attacgcggt cgatgtcaat aatatacaat ttgcaaagcg gttattggaa tatggagcga 53760 gtgtcacgct cgataatcaa tacggccatc cagaaaagca gttaccaaag agaagctagt 53820 tgatttatta ctgagttacc atcccactct agagactatg attgacgcat ttaatagaga 53880 tatacgctat ctatatcctg aaccattatt cgcctgtatc agatacgcct taatcctaga 53940 tgatgatttt ccttctaaag taagtatgat atcgccggtc gtcataagga actaaagcgc 54000 tatagagcag acattaatag aatgaagaat gcctacatat caggcgtctc catgtttgat 54060 atattattta aacgaagcaa acgccacaga ttgagatacg caaagaacaa tgagaggatc 54120 gactccatta aataa tttat catggagtga taatgtcctg tttccatggc atattacaaa 54180 atcgattccg tccaagatga taaaaacatt taccggcatc ataaacacgg agtttatttt 54240 atatgtctcg cataaacatt actaaaaaaa tatattgttc ggttttcttt cacatcttta 54300 attatgaaaa agtaaatcat tatgagatgg acgcatcgtt cgcgacagta tgtggtacat 54360 acctaacgta tttatggacg acggtaagaa tgaaggtcac gtttctgtca acaatgtcga 54420 cgcgatcgtg taacacgact cacaatagaa tctgtgaatg ctctcccgat catggatgca 54480 aggcatgtgt ttcccaaaca aaatgtggaa taggatacgg agtatccgga gacgtcatct 54540 gttctccgtg tggtctcgga acatattctc acaccgtctc ttccgcagat aaatgcgaac 54600 ccgtacccag aaataccttt aactatatcg atgtggaaat taacctgtat ccagttaacg 54660 acacatcgtg tactcggacg accactaccg gtctcagcga atccatctca acgtcggaac 54720 taactattac tatgaatcat aaagactgcg atcccgtctt cttaataagg tagcgacttc 54780 aggtttcttt acaggagaaa ggtgtgcact ctgaatttcg agattaaatg caataacaaa 54840 gattcttcct ccaaacagtt aacgaaagca aagaatgata ctatcatgcc gcattcggag 54900 acagtaactc tagcgtcgac atctatatac tatatagtaa taccaatact caagactacg 54960 aaactgatac aatctcttat catgtgggta atgtagccat atgcccggta gttgcgatat 55020 acataaactg atcactaatt ccaaacccac ccgcttttta tagtaagttt ttcacccata 55080 aatacaataa ttaatttctc gtaaaagtag aaaatatatt ctaatttatt gcacggtaag 55140 gaagtagaat cataaagaac agtactcaat caatagcaat catgaaacaa tatatcgta c 55200 tggcatgcat gtgcctgcca gtcttcagca atcatcctca tcgtgtacgg aagaagaaaa 55260 caaacatcat atgggaatcg atgttattat caaagtcaca aagcaagacc aaacaccgac 55320 cgatgataag atttgccaat ccgtaacgga aattacagag tccgagtcag atccagatcc 55380 cgaggtggaa tcagtcgagg atgtagatcc tcctaccact tattactcca tcatcggtgg 55440 aggtctgaga atgaactttg gattcaccaa atgtcctcag attaaatcca tctcagaatc 55500 cgctgatgga aagactgtga ggtgtctatc gacatcagat gtagcgaaga agagaaagac 55560 agcgacatca agacccatcc agtactcggg tctaacatct ctcataagaa agtgagttac 55620 gaagatatca tcggttcaac gatcgtcgat acaaaatgtg tcaagaatct agagtttagc 55680 gttcgtatcg gagacatgtg caaggaatca tctgaacttg aggtcaagta tgtcgacgga 55740 tcggcatctg aaggtgcaac cgatgatact tcactcatcg attcaacaaa actcaaagcg 55800 tgtgtctgaa tcgataactc tattcatctg aaattggatg agtagggtta atcgaacgat 55860 tcaggcacac cacgaattaa aaaagtgtac cggacactat attccggttt gcaaaacaaa 55920 aagttacctc tcgcgacttc ttctttttct gtctcaatag tgtgatacga ttatgacact 55980 attcctattt cctttcaggg tatcacaaaa atattaaacc tctttctgat g gtctcatac 56040 aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaatatt tttattctct 56100 ttctctcttt gatggtctca taaaatattt ttattctctt tctctctttg atggtctcat 56160 aaaaaatatt tttattctct ttctctcttt gatggtctca taaaatattt ttattctctt 56220 tctctctttg atggtctcat aaaaaatatt tttattctct ttctctcttt gatggtctca 56280 taaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc tctttctctc 56340 ttcaatggag tcataaaata tttttattct ctttctctct tcgatggtct cacaaaaata 56400 ttaaacctct ttctgatggt gtcactaaaa tatttttatt ctctttctct cttcaatgga 56460 gtcataaaat atttttattc tctttctctc tttgatggtc tcacaaaaat atttttattc 56520 tctttctctc tttgatggtc tcacaaaaat atttttattc tctttctctc tttgatggtc 56580 tcacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 56640 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 56700 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 56760 tctctttctc tctttgatgg tctcataaaa aatattaaac ctctttctga tggtgtcact 56820 aaaatatttt tattctcatt ctctcttcaa tggagtcata aaat attttt attctctttc 56880 tctcttcgat ggtctcacaa aaatattaaa cctctttctg atggtgtcac taaaatattt 56940 ttattctcat tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga 57000 tggtctcaca aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca 57060 ttctctcttc aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat 57120 aaaaaaagtt ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa 57180 tattaaacct ctttctgatg gtgtcactaa aatattttta ttctctttct ctcttcaatg 57240 gagtcataaa atatttttat tctctttctc tcttcgatgg tctcacaaaa atattaaacc 57300 tctttctgat ggtgtcacta aaatattttt attctcattc tctcttcaat ggagtcataa 57360 aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 57420 tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 57480 ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 57540 ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 57600 ttgatggtct cataaaaaat attaaacctc tttctgatgg tgtcactaaa atatttttat 57660 tctcattctc tcttcaatgg agtcataaaa tattttt att ctctttctct cttcgatggt 57720 ctcacaaaaa tattaaacct ctttctgatg gtgtcactaa aatattttta ttctcattct 57780 ctcttcaatg gagtcataaa atatttttat tctctttctc tctttgatgg tctcataaaa 57840 aaagttttac aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 57900 ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 57960 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 58020 ttttattctc tttctctctt tgatggtctc acaaaaatat taaacctctt tctgatggag 58080 tcgtaaaaaa gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt 58140 ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt 58200 aaacctcttt ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca 58260 ctaaaatatt ttttattctc tttctgatgc atcaactatt tcttaaacaa taacgtccaa 58320 caacatatac tcgtcgagct tatcaacatc ccctatgccc atctaggtta ccagacaatt 58380 gtatatcata aaataatgtt tataattttt acaaaaatat ttttattctc tttctctctt 58440 tgatggtctc ataaaaaaag ttttacaaaa atatttttat tctctttctc tctttgatgg 58500 tctcataaaa aatattaaac ctctttctga tggtgtcact aaaatatttt tattctcatt 58560 ctctcttcaa tggagtcata aaatattttt attctctttc tctcttcgat ggtctcacaa 58620 aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctcat tctctcttca 58680 atggagtcat aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt 58740 tacaaaaata tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa 58800 aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 58860 tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 58920 ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 58980 ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 59040 ttgatggtct cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg 59100 gtctcataaa aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctctt 59160 tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga tggtctcaca 59220 aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca ttctctcttc 59280 aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 59340 ttacaaaaat atttttattc tc tttctctc tttgatggtc tcataaaaaa agttttacaa 59400 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 59460 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 59520 tctctttctc tctttgatgg tctcataaaa aaagttttac aaaaatattt ttattctctt 59580 tctctctttg atggtctcat aaaaaatatt aaacctcttt ctgatggtgt cactaaaata 59640 tttttattct ctttctctct tcaatggagt cataaaatat ttttattctc tttctctctt 59700 cgatggtctc acaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc 59760 tctttctctc ttcaatggag tcataaaata tttttattct ctttctctct ttgatggtct 59820 cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg gtctcataaa 59880 aaaagtttta caaaaatatt tttattctct ttctctcttt gatggtctca taaaaaaagt 59940 tttacaaaaa tatttttatt ctctttctct ctttgatggt ctcataaaaa aagttttaca 60000 aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt tacaaaaata 60060 tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa aatattttta 60120 ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt tttattctct 60180 ttctctcttt gatgg tctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60240 atttttattc tcattttctc tttctctctt caatggagtc ataaaatatt tttattctct 60300 ttctctcttt gatggtctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60360 atttttattc tcattctctc ttcaatggag tcataaaaaa gttttatctc tttctctctt 60420 cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc 60480 tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatgcat caactatttc 60540 ttaaacaata acgtccaaca acatatactc atcccctatg cccatctagg ttaccagaca 60600 attgtatatc ataaaataat gtttataatt tacacgttaa aatcatataa taaaacgtag 60660 atcgtataat attttttggt atataaatga tctagtaaaa tccatgtagg ggatactgct 60720 cacatttttt ctttggtaca aaatttcaca caagttttta tacagacaaa ttcttgtcca 60780 tatattttaa aacattgact tttgtactaa gaaaaatatc tagactaact atctctttct 60840 ctttctctct tcgatggtct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 60900 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 60960 ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 61020 agttttat ct ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag 61080 tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat taaacctctt 61140 tctgatggtg tcactaaaat atttttattc tctttctctc ttcgatggtc tcacaaaaat 61200 attaaacctc tttctgatgg agtcgtaaaa aagttttatc tctttctcct tcgatggtct 61260 cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 61320 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 61380 ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa 61440 gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt ctgatggagt 61500 cgtaaaaaag ttttatctct ttctccttcg atggtctcac aaaaatatta aacctctttc 61560 tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac aaaaatatta 61620 aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac 61680 aaaaatatta aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctccttcga 61740 tggtctcaca aaaatattaa acctctttct gatggtctct ataaagcgat tgatttttct 61800 taccctctag agtttcctac ggtcgttggt cacacatttt tttctagaca ctaaataaat 61860 agtaagatta aattaattat aaaattatgt atataatatt aattataaaa ttatgtatat 61920 gatttactaa ctttagttag ataaattaat aatacataaa ttttagtata ttaatattat 61980 aaattataataa tacataaatt ttagtatat aatattatat tattagatgt gg cctattaga <210> 15 <211> 62068 <212> DNA <213> Artificial Sequence <220> <223> sMVA F3 <400> 15 ggcctagcag gccttttttt ctagacacta aataaatagt aagattaaat taattataaa 60 attatgtata taatattaat tataaaatta tgtatatgat ttactaactt tagttagata 120 aattaataat acataaattt tagtatatta atattataaa ttaataatac ataaatttta 180 gtatattaat attatatttt aaatatttat ttagtgtcta gaaaaaaagg ccggccgggt 240 attaataata tctatatttc cagcgttaag tgtaacatta aacagtttta attcacgtga 300 cgtggtatca attaaataat taatgcccaa tttggatata gcagcctgaa gctcatcttg 360 tttagttacg gatcctaatg agttattaag caatatatcg aacggatgaa cgaaggttgt 420 tttaagttgg tcacatactt tgtaatctag acatagatgc ggaagaacgg tagaaactat 480 acgaaataaa tattcagagt cctctaattg atcaagagta actattgact taataggcat 540 catttattta gtattaaatg acgaccgtac cagtgacgga tatacaaaac gatttaatta 600 cagagttttc agaagataat tatccatcta acaaaaatta tgaaataact cttcgtcaaa 660 tgtctattct aactcacgtt aacaacgtgg tagatagaga acataatgcc gccgtagtgt 720 catctccaga ggaaatatcc tcacaactta atgaagatct atttccagat gatgattctc 780 cggccactat tatcgaacga gtacaacctc atactactat tattgacgat actccacctc 840 ctacgtttcg t agagagtta ttgatatcgg aacaacgtca acaacgagaa aaaagattta 900 atattacagt atcgaaaaat gctgaagcaa taatggaatc tagatctatg atatcttcta 960 tgccaacaca aacaccatcc ttgggagtag tttatgataa agataaaaga attcagatgt 1020 tggaggatga agtggttaat cttagaaatc aacgatctaa tacaaaatca tctgataatt 1080 tagataattt taccagaata ctatttggta agactccgta taaatcaaca gaagttaata 1140 agcgtatagc catcgttaat tatgcaaatt tgaacgggtc tcccttatca gtcgaggact 1200 tggatgtttg ttcagaggat gaaatagata gaatctataa aacgattaaa caatatcacg 1260 aaagtagaaa acgaaaaatt atcgtcacta acgtgattat tattgtcata aatattatcg 1320 agcaagcatt gctaaaactc ggatttgaag aaatcaaagg actgagtacc gatatcactt 1380 cagaaattat cgatgtggag atcggagatg actgcgatgc tgtagcatca aaactaggaa 1440 tcggtaacag tccggttctt aatattgtat tgtttatact caagatattc gttaaacgaa 1500 ttaaaattat ttaatttaat acattcccat atccagacaa caatcgtctg gattaatctg 1560 ttcctgtcgt ctcataccgg acgacatatt aatcttttta ttagtaggca tctttttaga 1620 tggtttcttt ttcccagcat taactgagtc gatacctaga agatcgtgat tgatctctcc 1680 gaccattcca cgaacttct a attggccgtc tctgacggta ccataaacta ttttaccagc 1740 attagtaaca gcttggacaa tctgaccatc catcgcattg tacgatgtag tagtaactgt 1800 tgttctacgt ctaggagcac cagaagtatt tttggagccc ttggatgttg atgtagaaga 1860 agacgaggat tttgattttg gtttacatgt aatacatttt gtatcacatg cgccggcagt 1920 cacatctgtt tgagaattaa gattattgtt gcctcctttg acggctgcat ctccaccgat 1980 ttgcgctagt agatttttaa gctgtggtgt aatcttatta actgtttcga tataatcatc 2040 gtaactgctt ctaacggcta aatttttttt atccgccatt tagaagctaa aaatattttt 2100 atttatgcag aagatttaac tagattatac aatgaactaa tatgatcctt ttccagatta 2160 tttacaaact tggtattttt tggttctgga ggaggcgaat ttaaattcgg acttggattt 2220 ggattttgtg ggttcttgat cttattatac agcgcatata ggatggcgac ggtaactgct 2280 acgcaaatac cgatcaacaa aagaatacca atcatttatt gacaataact tcactattga 2340 tcaagtatgc aatatatcat cttttcacta aataagtagt aataatgatt caacaatgtc 2400 gagatatatg gacgataata atttagttca tggaaatatc gctatgattg gtatgaatga 2460 ctccgctaac tctgtggggc gcgcagtgct ttccccacat agaataaatt agcattccga 2520 ctgtgataat aataccaagt ataa acgcca taatactcaa tactttccat gtacgagtgg 2580 gactggtaga cttactaaag tcaataaagg cgaagataca cgaaagaatc aaaagaatga 2640 ttccagcgat tagcacgccg gaaaaataat ttccaatcat aagcatcata tccatttaac 2700 taataaaaat tttaaatcgc cgaatgaaca aagtggaata taaaccatat aaaaacaata 2760 gtttgtactg caaaaataat atctattttt gttttcgaag atatggtaaa attaaatagt 2820 agtacacagc atgttataac taacagcagc aacggctcgt aattacttat catttactag 2880 acgaaaaggt ggtgggatat tttcttgctc aaataatacg aatatatcac ccatccattt 2940 tatgcgatgt ttatatactc taatctttaa tagatctata gacgacgggt ttaccaacaa 3000 tatagatttt atcgattcat ctaatttaaa cccttcctta aacgtgaatg atctattatc 3060 tggcataacg atgactctac ccgatgaatc ggacaatgta ctgggccatg tagaataaat 3120 tatcaacgaa ttatcgtcta cgaacattta tatcatttgt tttaatttta gtacgcgaat 3180 aaatagatat aaaatagaaa ataacagata ttacaaccaa tgttatggcc gcgcccaacc 3240 aggtaggcag ttttatttta tcttttacta caggttctcc tggatgtacg tcaccaacgg 3300 cggacgtagt tctagtacaa ttagacgtaa gttccgcttg ggaatttttt aacgctaaag 3360 agttaacgtt aatcgtgcac ccaacgtatt tacatctagt tctttgaaca tcttgattat 3420 aatataacca ttttctatct ctagattcgt cggtgcactc atgtaaccaa cataccctag 3480 gtcctaaata tttatctccg gaattagatt ttggataatt cgcgcaccaa caatttctat 3540 ttcctttatg atcgttacaa aagacgtata atgccgtatc cccaaaagta aaataatcag 3600 gacgaataat tctaataaac tcagaacaat atctcgcatc catatgtttg gagcaaatat 3660 cggaataagt agacatagcc ggtttccgtt ttgcacgtaa ccattctaaa caattggggt 3720 ttccaggatc gtttctacaa aatccagtca tgaaatcatc acaatgttct gtcttgtaat 3780 tattattaaa tatttttgga cagtgtttgg tatttgtctt agaacaacat tttgccacgc 3840 tatcactatc gcccaggaga taatcctttt ttataaaatg acatcgttgc ccggatgcta 3900 tataatcagt agcgtgtttt aaatccttaa tatattcagg agttacctcg ttctgataat 3960 agattaatga tccaggacga aatttgaaag aactacatgg ttctccatga attaatacat 4020 attgtttagc aaattcagga actataaaac tactacaatg atctatcgac ataccatcta 4080 tcaaacaaaa cttgggttta atttctcccg gagatgtttc ataatagtac gtataacttt 4140 cttctgcaaa cttaacagct ctattatatt caggataatt aaaacctaat tccatatatt 4200 tgtctcgtat atctgctatt cctggtgcta ttttg attct attaagagta acggctgccc 4260 ccatttttaa taatcgtcag tatttaaact gttaaatgtt ggtatatcaa catttacctt 4320 atttcccgca gtataaggtt tgttgcaggt atactgttca ggaatggtta catttatact 4380 ttttctatag tcctgtcttt cgatgttcat cacatatgca aagaacagaa taaacaaaat 4440 aatgtaagaa ataatattaa atatctgtga attcgtaaat acattgattg ccataataat 4500 tacagcagct acaatacata caatagacat tcccacagtg ttgccattac ctccacgata 4560 catttgagtt actaagcaat aggtaataac taagctagta agaggcaata gaaaagatga 4620 gataaatatc atcaatatag agattagagg agggctatat agagccaaga cgaacaaaat 4680 caaaccgagt aacgttctaa catcattatt tttgaagatt cccaaataat cattcattcc 4740 tccataatcg ttttgcatca tacctccatc tttaggcata aacgattgct gctgttcctc 4800 tgtaaataaa tctttatcaa gcactccagc acccgcagag aagtcgtcaa gcatattgta 4860 atatcttaaa taactcattt atatattaaa aaatgtcact attaaagatg gagtataatc 4920 tttatgccga actaaaaaaa atgacttgtg gtcaacccct aagtcttttt aacgaagacg 4980 gggatttcgt agaagttgaa ccgggatcat cctttaagtt tctgatacct aagggatttt 5040 acgcctctcc ttccgtaaag acgagtctag tatttgaaac attaacaacg accgataata 5100 aaattactag tatcaatcca acaaatgcgc caaagttata tcctcttcaa cgcaaagtcg 5160 tatctgaagt agtttctaat atgaggaaaa tgatcgaatc aaaacgtcct ctatacatca 5220 ctcttcactt ggcgtgtgga tttggtaaga ctattaccac gtgttatctt atggctacac 5280 acggtagaaa aaccgtcatt tgcgtaccca ataaaatgtt aatacatcaa tggaagacac 5340 aggtagaggc agtcggattg gaacataaga tatccataga tggagtaagt agtctattaa 5400 aggaactaaa gactcaaagt ccggatgtat taatagtagt cagtagacat ctgacaaacg 5460 atgccttttg taaatatatc aataagcatt atgatttgtt catcttggat gaatcacata 5520 cgtataatct gatgaacaat acagcagtta caagattttt agcgtattat cctccgatga 5580 tgtgttattt tttaactgct acacctagac catctaacag aatttattgt aacagtatta 5640 ttaatattgc caagttatcc gatctaaaaa aaactatcta tgcagtagat agtttttttg 5700 agccatattc cacagataat attagacata tgataaaacg attagatgga ccatctaata 5760 aatatcatat atataccgag aagttattat ctgtagacga gcctagaaat caacttattc 5820 ttaataccct ggtagaagaa ttcaagtcag gaactattaa tcgcatttta gttattacta 5880 aactacgtga acatatggta ttcttctaca aacgattatt agattt tttc ggatcagagg 5940 ttgtatttat aggagacgcc caaaatagac gtactccaga tatggtcaaa tcaatcaagg 6000 aactaaatag atttatattc gtatccacct tattttattc cggtactggt ttagatattc 6060 ctagtttgga ttctttgttc atttgctcgg cagtaatcaa caatatgcaa atagagcaat 6120 tactagggag ggtatgtcga gaaacagaac tattagatag gacggtatat gtatttccta 6180 gcacatccat caaagaaata aagtacatga taggaaattt cgttcaacga attattagtc 6240 tgtctgtaga taaactagga tttaaacaaa aaagttatcg gaaacatcaa gaatccgatc 6300 ccacttctgt atgtacaaca tcctccagag aagaacgtgt attaaataga atatttaact 6360 cgcaaaatcg ttaagaagtt taagcgacga tccgcatgct gcgcaggcca gtgtattacc 6420 cctcatagta ttaatataat ccaatgatac ttttgtgatg tcggaaatct taaccaattt 6480 agactgacag gcagaacacg tcatgcaatc atcatcgtca tcgataactg tagtcttggg 6540 cttctttttg cggctcttca ttccggaacg cacattggtg ctatccattt aggtagtaaa 6600 aaataagtca gaatatgccc tatagcacga tcgtgcaaaa cctggtatat cgtctctatc 6660 tttatcacaa tatagtgtat cgacatcttt attattattg acctcgttta tcttggaaca 6720 tggaatggga acatttttgt tatcaacggc cacctttgcc ttaattccag a tgttgtaaa 6780 attataacta aacagtctat catcgacaca aatgaaattc ttgtttagac gtttgtagtt 6840 tacgtatgcg gctcgttcgc gtctcatttt ttcagatatt gcaggtacta taatattaaa 6900 aataagaatg aaataacata ggattaaaaa taaagttatc atgacttcta gcgctgattt 6960 aactaactta aaagaattac ttagtctgta caaaagtttg aaattttcag attctgcggc 7020 tatagaaaag tataattctt tggtagaatg gggaacatct acttactgga aaataggcgt 7080 gcaaaaggta gctaatgtcg agacgtcaat atctgattat tatgatgagg taaaaaataa 7140 accgtttaat attgatccgg gctattacat tttcttaccg gtatattttg ggagcgtctt 7200 tatttattcg aagggtaaaa atatggtaga acttggatct ggaaactctt ttcaaatacc 7260 agatgatatg cgaagtgcgt gtaacaaagt attagacagc gataacggaa tagactttct 7320 gagatttgtt ttgttaaaca atagatggat aatggaagat gctatatcaa aatatcagtc 7380 tccagttaat atatttaaac tagctagtga gtacggatta aacataccca aatatttaga 7440 aattgaaata gaggaagaca cattatttga cgacgagtta tactctatta tagaacgctc 7500 tttcgatgat aaatttccaa aaatatccat atcgtatatt aagttgggag aacttaggcg 7560 gcaagttgta gactttttca aattctcatt catgtatatt gagtccatca aggtaga tcg 7620 tataggagat aatattttta ttcctagcgt tataacaaaa tcaggaaaaa agatattagt 7680 aaaagatgta gaccatttaa tacgatccaa ggttagagaa catacatttg taaaagtaaa 7740 aaagaaaaac acattttcca ttttatacga ctatgatgga aacggaacag aaactagagg 7800 agaagtaata aaacgaatta tagacactat aggacgagac tattatgtta acggaaagta 7860 tttctctaag gttggtagtg caggcttaaa gcaattgact aataaattag atattaatga 7920 gtgcgcaact gtcgatgagt tagttgatga gattaataaa tccggaactg taaaacgaaa 7980 aataaaaaac caatcagcat ttgatttaag cagagaatgt ttgggatatc cagaagcgga 8040 ttttataacg ttagttaata acatgcggtt caaaatagaa aattgtaagg ttgtaaattt 8100 caatattgaa aatactaatt gtttaaataa cccgagtatt gagactatat atggaaactt 8160 taaccagttc gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat tattcgagtg 8220 aaataatatg cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt ttagaagtca 8280 aggataactc cgttagggta ttggatatat caaaattaga ctggagttct gattgggaaa 8340 ggcacatagc taaagatttg tcacaatatg aatacactac agttcttcta gaacgtcagc 8400 ctagaaggtc gccgtacgtc aaatttatct attttattaa aggcttttta tatcatacat 84 60 cggctgccaa agttatttgc gtctcgcctg tcatgtctgg taattcatat agagatcgaa 8520 aaaagagatc ggtcgaagca tttcttgatt ggatggacac attcggattg cgagactccg 8580 ttccggatag acgcaaatta gacgatgtag cggatagttt caatttggct atgagatacg 8640 tattagataa atggaatact aattatacac cttataatag gtgtaaatct agaaattaca 8700 taaaaaaaat gtaataacgt tagtaacgcc attatggata atctatttac ctttctacat 8760 gaaatagaag atagatatgc cagaactatt tttaactttc atctaataag ttgcgatgaa 8820 ataggagata tatatggtct tatgaaagaa cgcatttcct cagaggatat gtttgataat 8880 atagtgtata ataaagatat acatcatgcc attaagaaac tagtgtattg cgacatccaa 8940 cttactaaac acattattaa tcagaatacg tatccggtat ttaacgattc ttcacaagtg 9000 aaatgttgtc attatttcga tataaactca gataatagca atattagctc tcgtacagta 9060 gagatatttg agagggaaaa gtcatctctt gtatcatata ttaaaactac caataagaag 9120 agaaaggtca attatgggga aataaagaaa actgtacatg gaggcactaa tgcaaattac 9180 ttttccggta aaaagtctga tgagtatctg agcactacag tcaggtccaa cattaatcaa 9240 ccttggatca aaaccatttc taagagaatg agagtagata tcattaatca ctctatagta 9300 acg cgtggaa aaagctctat attacaaact atagaaatta tttttactaa tagaacatgt 9360 gtgaaaatat tcaaggattc tactatgcac attattctat ccaaggacaa ggatgaaaag 9420 gggtgtatac acatgattga caaattattc tatgtctatt ataatttatt tctgttgttc 9480 gaggatatca tccaaaacga gtactttaaa gaagtagcta atgttgtaaa ccacgtactc 9540 acggctacgg cattagatga gaaattattc ctaattaaga aaatggctga acacgatgtt 9600 tatggagtta gcaatttcaa aatagggatg tttaacctga catttattaa gtcgttggat 9660 cataccgttt tcccctctct gttagatgag gatagcaaaa taaagttttt taaggggaaa 9720 aagctcaata ttgtagcatt acgatctctg gaggattgta taaattacgt gactaaatcc 9780 gagaatatga tagaaatgat gaaggaaaga tcgactattt taaatagcat agatatagaa 9840 acggaatcgg tagatcgtct aaaagaattg cttctaaaat gaaaaaaaaa cactaattca 9900 gaaatggatc aacgactcgg atataagttt ttggtgcctg atcctaaagc cggagttttt 9960 tatagaccgt tacatttcca atatgtatcg tattctaatt ttatattgca tcgattgcat 10020 gaaatcttga ccgtcaagcg gccactctta tcgtttaaga ataatacaga acgaattatg 10080 atagaaatta gcaatgttaa agtgactcct ccagattact cacctataat cgcgagtatt 10140 aaaggt aaga gttatgacgc attagccacg ttcactgtaa atatctttaa agaggtaatg 10200 accaaagagg gtatatccat cactaaaata agtagttatg agggaaaaga ttctcatttg 10260 ataaaaattc cgctactaat aggatacggg aataaaaatc cacttgatac agccaagtat 10320 cttgttccta atgtcatagg tggagtcttt atcaataaac aatctgtcga aaaagtagga 10380 attaatctag tagaaaagat tacaacatgg ccaaaattta gggttgttaa gccaaactca 10440 ttcactttct cgttttcctc cgtatcccct cctaatgtat taccgacaag atatcgccat 10500 tacaagatat ctctggatat atcacaattg gaagcgttga atatatcatc gacaaagaca 10560 tttataacgg tcaatattgt tttgctgtct caatatttat ctagagtgag tctagaattc 10620 attagacgta gtttatcata cgatatgcct ccagaagttg tctatctagt aaacgcgata 10680 atagatagtg ctaaacgaat tactgaatct attactgact ttaatattga tacatacatt 10740 aatgacctgg tggaagctga acacattaaa caaaaatctc agttaacgat caacgagttc 10800 aaatatgaaa tgctgcataa ctttttacct catatgaact atacacccga tcaactaaag 10860 ggattttata tgatatcttt actaagaaag tttctctact gtatctacca cacttctaga 10920 tatccagata gagattcgat ggtttgtcat cgcatcctaa cgtacggcaa atattttgag 1098 0 acgttggcac atgatgaatt agagaattac ataggcaaca tccgaaacga tatcatgaac 11040 aatcacaaga acagaggcac ttacgcggta aacattcatg tactaacaac tcctggactt 11100 aatcatgcat tttctagtct attgagtgga aagttcaaaa agtcagacgg tagttatcga 11160 acacatcctc actattcatg gatgcagaat atttctattc ctaggagtgt tggattttat 11220 ccggatcaag taaagatttc aaagatgttt tctgtcagaa aataccatcc aagtcaatat 11280 ctttactttt gttcatcgga cgttccggaa agaggtcctc aggtaggttt agtatctcaa 11340 ttgtctgtct tgagttccat tacaaatata ctaacgtctg agtatttgga tttggaaaag 11400 aaaatttgtg agtatatcag atcatattat aaagatgata taagttactt tgaaacagga 11460 tttccaatca ctatagaaaa tgctctagtc gcatctctta atccaaatat gatatgtgat 11520 tttgtaactg actttagacg tagaaaacgg atgggattct tcggtaactt ggaggtaggt 11580 attactttag ttagggatca catgaatgaa attcgcatta atattggagc gggaagatta 11640 gtcagaccat tcttggttgt ggataacgga gagctcatga tggatgtgtg tccggagtta 11700 gaaagcagat tagacgacat gacattctct gacattcaga aagagtttcc gcatgtcatc 11760 gaaatggtag atatagaaca atttactttt agtaacgtat gtgaatcggt tcaaaaa ttt 11820 agaatgatgt caaaggatga aagaaagcaa tacgatttat gtgactttcc tgccgaattt 11880 agagatggat atgtagcatc ttcactagtg ggaatcaatc acaattctgg acccagagct 11940 attcttggat gtgctcaagc taaacaagct atctcttgtc tgagctcgga tatacgaaat 12000 aaaatagaca atggaattca tttgatgtat ccagagaggc caatcgtgat tagtaaggct 12060 ttagaaactt caaagattgc ggctaattgc ttcggccaac atgttactat agcattaatg 12120 tcgtacaaag gtatcaatca agaggatgga attatcatca aaaaacaatt tattcagaga 12180 ggcggtctcg atattgttac agccaagaaa catcaagtag aaattccgtt ggaaaacttt 12240 aataacaaag aaagagatag gtctaacgcc tattcaaaat tagaaagtaa tggattagtt 12300 agactgaatg ctttcttgga atccggagac gctatagcac gaaatatctc atcaagaact 12360 cttgaagatg attttgctag agataatcag attagctttg atgtttccga aaaatatacc 12420 gatatgtaca aatctcgcgt tgaacgagta caagtagaac ttactgacaa agttaaggta 12480 cgagtattaa ccatgaaaga aagaagaccc attctaggag acaaatttac cactagaacg 12540 agtcaaaagg gaacagtcgc gtatatcgcg gatgaaacgg aacttccata cgatgaaaat 12600 ggtatcacac cagatgtcat tattaattct acatccatct tctctagaaa aactatatct 12660 atgttgatag aggttatttt aacagccgca tattctgcta agccgtacaa caataaggga 12720 gaaaaccgac ctgtctgttt tcctagtagt aacgaaacat ccatcgatac atatatgcaa 12780 ttcgctaaac aatgttatga gcattcaaat ccgaaattgt ctgatgaaga attatcggat 12840 aaaatctttt gtgaaaagat tctctatgat cctgaaacgg ataagcctta tgcatccaaa 12900 gtattttttg gaccaattta ttacttgcgt ctgaggcatt taactcagga caaggcaacc 12960 gttagatgta gaggtaaaaa gacgaagctc attagacagg cgaatgaggg acgaaaacgt 13020 ggaggaggta tcaagttcgg agaaatggag agagactgtt taatagcgca tggtgcagcc 13080 aatactatta cagaagtttt gaaagattcg gaagaagatt atcaagatgt gtatgtttgt 13140 gaaaattgtg gagacatagc agcacaaatc aagggtatta atacatgtct tagatgttca 13200 aaacttaatc tctctcctct cttaacaaaa attgatacca cgcacgtatc taaagtattt 13260 cttactcaaa tgaacgccag aggcgtaaaa gttaaattag atttcgaacg aaggcctcct 13320 tcgttttata aaccattaga taaagttgat ctcaaaccgt cttttctggt gtaatattct 13380 agtttggtag tagatacata tcaatatcat caaattcgag atccgaatta taaaatgggc 13440 gtggattgtt aactatagaa tcggacgtct gatattcgaa aa tctgtgga gttttaggtt 13500 ttggtggagg tgtaactgct acttgggata ctgaagtctg atattcagaa agctggggga 13560 tgttctggtt cgacatccac cgatggtgtc acatcactcactaa tcggtacatcggt tggct gacgtcattggt ttaggt gacgtcattggt 13620 gacctctgtgt acttcaatgc gaggaaatgt ataatttggt aatggtttct catgtggatc tgaagaagag 13740 gtaagatatc tactagaaag ataccgatca cgttctagtt ctcttttgta gaacttaact 13800 ttttctttct ccgcatctag ttgatattcc aacctcttca cgttcgcatg ggttacctcc 13860 gcagttttta cgagcgattt cacgttcagc cttcatgcgt cttatagcat gaattcgctt 13920 atcgttatcg ggtttagctt ctgtcacctt agcaattcct tttttattaa actctacata 13980 atcatatcca tttctattgt ttgttctaat ataaacgagt atagcatcat tgctaaattt 14040 ttcaatagta tcgaaaacag aatatcctaa accatataat atatattcag gaacactcaa 14100 actaaatgtc caggattctc ctaaatacgt aaactttaat agtgcgaaat cattcaaaaa 14160 tctaccactt atagatagat agatagtaca taaatgcgta tagtagtcta cctatctctt 14220 tattatgaaa accggcatta cgatcatata tgtcgtgata tacctgtgat ccgtttacgt 14280 taaaccataa atacatgggt gatcctataa acatgaattt atttctaatt ctcagagcta 14340 tagttaattg accgtgtaat atttgcttac atgcatactt gatacgatca ttaataagat 14400 ttttatcatt gctcgttatt tcagaatcgt atatataagg agtaccatcg tgattcttac 14460 cagatattat acaaaatact atatataaaa tatattgacc cacgttagta atcatgtaa a 14520 tgtttaacgt tttaaatttt gtattcaatg atccattatc atacgctagc atggtcttat 14580 gatattcatt ctttaaaata taatattgtg ttagccattg cattggggct cctaatggag 14640 attttttatt ctcatccatt ttaggatagg ctttcataaa gtccctaata acttcgtgaa 14700 taatgtttct atgttttcta ctgatgcatg tatttgcttc gattttttta tcccatgttt 14760 catctatcat agatttaaac gcagtaatgc tcgcaacatt aacatcttga accgttggta 14820 caattccgtt ccataaattt ataatgttcg ccatttatat aactcatttt ttgaatatac 14880 ttttaattaa caaaagagtt aagttactca tatggacgcc gtccagtctg aacatcaatc 14940 tttttagcca gagatatcat agccgctctt agagtttcag cgtgattttc caacctaaat 15000 agaacttcat cgttgcgttt acaacacttt tctatttgtt caaactttgt tgttacatta 15060 gtaatctttt tttccaaatt agttagccgt tgtttgagag tttcctcatt gtcgtcttca 15120 tcggctttaa caattgcttc gcgtttagcc tctggctttt tagcagccgt tgtagaaaaa 15180 aattcagttg ctggaattgc aagatcgtca tctccgggga aaagagttcc gtccatttaa 15240 agtacagatt ttagaaactg acactctgcg ttatttatat ttggtacaac acatggatta 15300 taaatattga tgttaataac atcagaaaat gtaaagtcta tacattgttg c atcgtgtta 15360 aattttctaa tggatctagt attattgggt ccaacttctg cctgaaatcc aaatatggaa 15420 gcggatacaa aaccgtttcc tggataaacc acacatctcc acttttgctt tacatcagaa 15480 attgtgtcgt tgacatcttg aactctccta tctaatgccg gtgttccacc tatagatttt 15540 gaatattcga atgctgcatg agtagcatta aattccttaa tattgccata attttcatat 15600 attgagtaac cctggataaa aagtaaacac accgcagccg tagctaccac aataaaaaaa 15660 attgatagag agttcattta taatctatta gaagctgaca aaattttttt acacgcatca 15720 gacaatgctt taataaatag ttcaacatct acttttgtca tatcgaaccg atggtatgat 15780 tctaacctag aattacatcc gaaaaagttg actatgttca tagtcattaa gtcattaaca 15840 aacaacattc cagactctgg attataagac gatactgttt cgtcacaatt acctacctta 15900 atcatgtgat tatgaatatt ggctattaga gcaccttcta agaaatctat aatatctttg 15960 aaacacgatt taaaatcaaa ccacgaatat acttctacga agaaagttag tttacccata 16020 ggagaaataa ctataaatgg agatctaaat acaaaatccg gatctatgat agttttaaca 16080 ttattatatt ctctattaaa tacctccaca tctaaaaatg ttaattttga aactatgtct 16140 tcgtttatta ccgtacctga actaaacgct ataagctcta ttgt ttgaga actctttaaa 16200 cgatattctt gaaatacatg taacaaagtt tcctttaact cggtcggttt atctaccata 16260 gttacagaat ttgtatcctt atctataata taataatcaa aatcgtataa agttatataa 16320 ttatcgcgtt cagattggga tcttttcaaa tagactaaaa accccatttc tctagtaagt 16380 atcttatgta tatgtttgta aaatatcttc atggtgggaa tatgctctac cgcagttagc 16440 cattcctcat tgacagcggt agatgtatta gacaaaacta ttccaatgtt taacaagggc 16500 cattttacga gattattaaa tccttgtttg ataaatgtag ccaatgaggg ttcgagttca 16560 acgacgattg aattctcttc ccgcggatgc tgcatgatga acgacgggat gttgttcgat 16620 tgatttggaa ttctttttcg actttttgtt tatattaaat attttaaaat ttatagcgga 16680 tagcaattca tgtaccacgg ataatgtaga cgcgtattgc gcatcgatat ctttattatt 16740 agataaattt atcaataaat gtgagaagtt tgcctcgtta aggtcttcca tttaaatatt 16800 atataaacat ttgtgtttgt atcttattcg tcttttatgg aatagttttt tactagtaaa 16860 gctgcaatta cacactttgt ccgtaaaaca taaatataaa caccagcttt tatcaatcgt 16920 tccaaaaagt cgacggcgga catttttaac atggcatcta ttttaaatac acttaggttt 16980 ttggaaaaaa catcatttta taattgtaac gattcaa taa ctaaagaaaa gattaagatt 17040 aaacataagg gaatgtcatt tgtattttat aagccaaagc attctaccgt tgttaaatac 17100 ttgtctggag gaggtatata tcatgatgat ttggttgtat tggggaaggt aacaattaat 17160 gatctaaaga tgatgctatt ttacatggat ttatcatatc atggagtgac aagtagtgga 17220 acaatttaca aattgggatc gtctatcgat agactttctc taaataggac tattgttaca 17280 aaagttaata attataatta tgatacattt tttgacgatg atgattgatc gctattgcac 17340 aattttgttt ttttactttc taatatagcg tttagattct ttttcatgtg cgaatattga 17400 tttactaaaa tatctatgtt taacttttgt tctataacgt ccttatcggc ggtatcggta 17460 catatacgta attcaccttc acaaaatacg gagtcttcga taataatagc caatcgatta 17520 ttggatctag ctgtctgtat catattcaac atgtttaata tatcctttcg tttccccttt 17580 acaggcatcg atcgtagcat attttccgcg tctgagatgg aaatgttaaa actacaaaaa 17640 tgcgtaatgt tagcccgtcc taatattggt acgtgtctat aagtttggca tagtagaata 17700 atagacgtgt ttaaatgcct tccaaagttt aagaattcta ttagagtatt gcattttgat 17760 agtttatcgc ctacatcatc aaaaataagt aaaaagtgtg ctgatttttt atgattttgt 17820 gcgacagcaa tacatttttc tatgttactt ttagttcgta tcagattata ttctagagat 17880 tcctgactac taacgaaatt aatatgattt ggccaaatgt atccatcata atctggatta 17940 taaacgggtg taaacaagaa tacatgttta tattttttaa ctagtgtaga aaacagagat 18000 agtaaataga tagtttttcc agatccagat cctcccgtta aaaccattct aaacggcatt 18060 tttaataaat tttctcttga aaattgtttt tcttggaaac aattcataat tatatttaca 18120 gttactaaat taatttgata ataaatcaaa atatggaaaa ctaaggtcgt tagtagggag 18180 gagaacaaag aaggcacatc gtgacataaa taacatttat tatcatgatg acaccagaaa 18240 acgacgaaga gcagacatct gtgttctccg ctactgttta cagagacaaa attcagggaa 18300 agaataaacg caaacgcgtg attggtctat gtattagaat atctatggtt atttcactac 18360 tatctatgat taccatgtcc gcgtttctca tagtgcgcct aaatcaatgc atgtctgcta 18420 acgaggctgc tattactgac gccgctgttg ccgttgctgc tgcatcatct actcatagaa 18480 aggttgcgtc tagcactacg caatatgatc acaaagaaag ctgtaatggt ttatattacc 18540 agggttcttg ttatatatta cattcagact accagttatt ctcggatgct aaagcaaatt 18600 gcactgcgga atcatcaaca ctacccaata aatccgatgt cttgactacc tggctcattg 18660 attatgttaa ggatacatgg gg atctgatg gtaatccaat tacaaaaact acatccgatt 18720 atcaagattc tgatgtatca caagaagtta gaaagtattt ttgtgttaaa acaatgaact 18780 aatatttatt tttgtacatt aataaatgaa atcgcttaat agacaaactg taagtaggtt 18840 taagaagttg tcggtgccgg tcgctataat gatgatactc tcaaccatta ttagtggcat 18900 aggaacattt ctgcattaca aagaagaact gatgcctagt gcttgcgcca atggatggat 18960 acaatacgat aaacattgtt atttagatac taacattaaa atgtctacag ataatgcggt 19020 ttatcagtgt cgtaaattac gagccagatt gcctagaccg gatactagac atctgagagt 19080 attgtttagt attttttata aagattattg ggtaagttta aaaaagacca atgataaatg 19140 gttagatatt aataatgata aagatataga tattagtaaa ttaacaaatt ttaaacaact 19200 aaacagtacg acggatgctg aagcgtgtta tatatacaag tctggaaaac tggttaaaac 19260 agtatgtaaa agtactcaat ctgtactatg tgttaaaaaa ttctacaagt gacaacaaaa 19320 aatgaattaa taataagtcg ttaacgtacg ccgccatgga cgccgcgttt gttattactc 19380 caatgggtgt gttgactata acagatacat tgtatgatga tctcgatatc tcaatcatgg 19440 actttatagg accatacatt ataggtaaca taaaaactgt ccaaatagat gtacgggata 19500 taaaatattc cgaca tgcaa aaatgctact ttagctataa gggtaaaata gttcctcagg 19560 attctaatga tttggctaga ttcaacattt atagcatttg tgccgcatac agatcaaaaa 19620 ataccatcat catagcatgc gactatgata tcatgttaga tatagaagat aaacatcagc 19680 cattttatct attcccatct attgatgttt ttaacgctac aatcatagaa gcgtataacc 19740 tgtatacagc tggagattat catctaatca tcaatccttc agataatctg aaaatgaaat 19800 tgtcgtttaa ttcttcattc tgcatatcag acggcaatgg atggatcata attgatggga 19860 aatgcaatag taatttttta tcataaaagt tgtaaagtaa ataataaaac aataaatatt 19920 gaactagtag tacgtatatt gagcaatcag aaatgatgct ggtacctctt atcacggtga 19980 ccgtagttgc gggaacaata ttagtatgtt atatattata tatttgtagg aaaaagatac 20040 gtactgtcta taatgacaat aaaattatca tgacaaaatt aaaaaagata aagagttcta 20100 attccagcaa atctagtaaa tcaactgata gcgaatcaga ctgggaggat cactgtagtg 20160 ctatggaaca aaacaatgac gtagataata tttctaggaa tgagatattg gacgatgata 20220 gcttcgctgg tagtttaata tgggataacg aatccaatgt tatggcgcct agcacagaac 20280 acatttacga tagtgttgct ggaagcacgc tgctaataaa taatgatcgt aatgaacaga 20340 ctatttat ca gaacactaca gtagtactta atgaagatac caaacagaat cctaactatt 20400 catccaatcc tttcgtaaat tataataaaa ccagtatttg tagcaagtca aatccgttca 20460 ttacagaact caacaataaa tttagtgaga ataatccgtt tagacgagca catagcgatg 20520 attatcttaa taagcaagaa caagatcatg aacacgatga tatagaatca ttggtgtgat 20580 tagtttcctt tttataaaat tgaagtaata tttagtatta ttgctgccgt cacgttgtac 20640 aaatggagat attccctgta ttcggcattt ctaaaattag caattttatt gctaataatg 20700 actgtagata ttatatagat acagaacatc aaaaaattat atctgatgag atcaatagac 20760 agatggatga aacggtactt cttaccaaca tcttaagcgt agaagttgta aatgacaatg 20820 agatgtacca tcttattcct catagattat cgacgattat actctgtatt agttctgtcg 20880 gaggatgtgt tatctctata gataatgacg tcaatggcaa aaatattcta acctttccca 20940 ttgatcatgc tgtaatcata tccccactga gtaaatgtgt cgtagttagc aagggtccta 21000 caaccatatt ggttgttaaa gcggatatac ctagcaaacg attggtaaca tcgtttacaa 21060 acgacatact gtatgtaaac aatctatcac tgattaatta ttcgccgttg tctgtattca 21120 ttattagacg agttaccgac tatttggata gacacatatg cgatcagata tttgcgaata 21180 ataagtggta ttccattata accatcgaca ataagcagtt tcctattcca tcaaactgta 21240 taggtatgtc ctctgccaag tacataaatt ctagcatcga gcaagatact ttaatacatg 21300 tttgtaacct cgagcatcca ttcgacttag tatacaaaaa aatgcagtcg tacaattctg 21360 tacctatcaa ggaacaaata ttgtacggta gaattgataa tataaatatg agcattagta 21420 tttctgtgga ttaatagatt tctagtatgg ggatcattaa tcatctctaa tctctaaata 21480 cctcataaaa cgaaaaaaaa gctattatca aatactgtac ggaatggatt cattctcttc 21540 tctttttatg aaactctgtt gtatatctac tgataaaact ggaagcaaaa aatctgataa 21600 aaagaataag aataagatca aggattatta taaaataaca atagttcctg gttcctcttc 21660 cacgtctact agctcgtggt attatacaca tgcctagtaa tagtctcttt gcgttgacgg 21720 aaagcagact agaaataaca ggctaaaatg ttcagacacc ataatagttc ccaacccaga 21780 taataacaga gtaccatcaa cacattcctt taaactcaat cccaaaccca aaaccgttaa 21840 aatgtatccg gccaattgat agtagataat gaggtgtaca gcgcatgatg atttacacag 21900 taaccaaaat gaaaatactt tagtaattat aagaaatata gatggtaacg tcatcatcaa 21960 caatccaata atatgccgga gagtaaacat tgacggataa aacaaaaatg ctccgcata a 22020 ctctatcatg gcaataacac aaccaaatac ttgtaagatt cctaaattag tagaaaatac 22080 aacggatatc gatgtataag tgatctcgag aaataataag aataaagtaa tgcccgtaaa 22140 gataaacatc aacattgttt ggtaatcatt aaaccaatta gtatgaagtt gaactaattt 22200 cacagtagat tttattccag tattatcccc gcatgtataa gtacctggta agatatcttt 22260 atattccata atcaatgaga catcactatc tgataacgaa tgaagtctag cactagtatg 22320 ccatttactt aatattgtcg tcttggaagt tttattataa gttaaaatat catggttatc 22380 caatttccat ctaatatact ttgtcggatt atctatagta cacggaataa tgatggtatc 22440 attacatgct gtatactcta tggtctttgt agttgttata acaaccaacg tatagaggta 22500 tatcaacgat attctaactc ttgacatttt ttatttattt aaaatgatac ctttgttatt 22560 tattttattc tattttgcta acggtattga atggcataag tttgaaacga gtgaagaaat 22620 aatttctact tacttattag acgacgtatt atacacgggt gttaatgggg cggtatacac 22680 attttcaaat aataaactaa acaaaactgg tttaactaat aataattata taacaacatc 22740 tataaaagta gaggatgcgg aaccaataac ggaaatccca aatgttggaa aatagacggt 22800 tcagacgacc caaaacatag aggtagagga tacgctcctt atcaaaatag c aaagtaacg 22860 ataatcagtc acaacggatg tgtactatct gacataaaca tatcaaaaga aggaattaaa 22920 cgatggagaa gatttgacgg accatgtggt tatgatttat acacggcgga taacgtaatt 22980 ccaaaagatg gtttacgagg agcattcgtc gataaagatg gtacttatga caaagtttac 23040 attcttttca ctgatactat cggctcaaag agaattgtca aaattccgta tatagcacaa 23100 atgtgcctaa acgacgaagg tggtccatca tcattgtcta gtcatagatg gtcgacgttt 23160 ctcaaagtcg aattagaatg tgatatcgac ggaagaagtt atagacaaat tattcattct 23220 agaactataa aaacagataa tgatacgata ctatatgtat tcttcgatag tccttattcc 23280 aagtccgcat tatgtaccta ttctatgaat accattaaac aatctttttc tacgtcaaaa 23340 ttggaaggat atacaaagca attgccgtct ccagctcctg gtatatgttt accagctgga 23400 aaagttgttc cacataccac gtttgaagtc atagaaaaat ataatgtact agatgatatt 23460 ataaagcctt tatctaacca acctatcttc gaaggaccgt ctggtgttaa atggttcgat 23520 ataaaggaga aggaaaatga acatcgggaa tatagaatat acttcataaa agaaaattct 23580 atatattcgt tcgatacaaa atctaaacaa actcgtagct cgcaagtcga tgcgcgacta 23640 ttttcagtaa tggtaacttc gaaaccgtta tttatagcag atat agggat aggagtagga 23700 atgccacaaa tgaaaaaaat acttaaaatg taatcttaat cgagtacacc gcacgacaat 23760 gaacaaacat aagacagatt atgctggtta tgcttgctgc gtaatatgcg gtctaattgt 23820 tggaattatt tttacagcga cactattaaa agttgtagaa cgtaaattag ttcatacacc 23880 atcaatagat aaaacgataa aagatgcata tattagagaa gattgtccta ctgactggat 23940 aagctataat aataaatgta tccatttatc tactgatcga aaaacctggg aggaaggacg 24000 taatgcatgc aaagctctaa atccaaattc ggatctaatt aagatagaga ctccaaacga 24060 gttaagtttt ttaagaagca ttagacgcgg atattgggta ggagaatccg aaatattaaa 24120 ccagacaacc ccatataatt ttatagctaa aaatgccacg aagaatggaa ctaaaaaacg 24180 gaaatatatt tgtagtacaa cgaatactcc caaactacat ttttatcata ccactacttc 24240 ggttagatgt tttagaaaaa aataaatatc gccgtaccgt tcttgttttt ataaaaataa 24300 caattaacaa ttatcaaatt ttttctttaa tattttacgt ggttgaccat tcttggtggt 24360 aaaataatct cttagtgttg gaatggaatg ctgtttaatg tttccgcact catcgtatat 24420 tttgacgtat gcagtcacat cgtttacgca atagtcagac tgtagttcta tcatgcttcc 24480 tacatcagaa ggaggaacag ttttaaagtc tcttggt ttt aatctattgc cattagtttt 24540 catgaaatcc tttgttttat ccacttcaca ttttaaataa atgtccacta tacattcttc 24600 tgttaatttt actagatcgt catgggtcat agaatttata ggttccgtag tccatggatc 24660 caaactagca aacttcgcgt atacggtatc gcgattagtg tatacaccaa ctgtatgaaa 24720 attaagaaaa cagtttaata aatcaacaga aatatttaat cctccgtttg atacagatgc 24780 gccatattta tggatttcgg attcacacgt tgtttgtctg aggtgttcgt ctagtgttgc 24840 ttctacgtaa acttcgattc ccatatattc tttattgtca gaatcgcata ccgatttatc 24900 atcatacact gtttgaaaac taaatggtat acacatcaaa ataataaata ataacgagta 24960 cattctgcaa tattgttatc gtaattggaa aaatagtgtt cgagtgagtt ggattatgtg 25020 agtattggat tgtatatttt attttatatt ttatattttg tagtaagaat agaatgctaa 25080 tgtcaagttt attccaatag atgtcttatt aaaaaacata tataataaat aacaatggct 25140 gaatggcata aaattatcga ggatatctca aaaaataata agttcgagga tgccgccatc 25200 gttgattaca agactacaaa gaatgttcta gctgctattc ctaacagaac atttgccaag 25260 attaatcctc tcatcactaa tcgtaatatt ctaaaacctc ttattggtca gaaatattgt 25320 attgtatata ctaactctct aatggatgag aacacgtatg ctatggagtt gcttactggg 25380 tacgcccctg tatctccgat cgttatagcg agaactcata ccgcacttat atttttgatg 25440 ggtaagccaa caacatccag acgtgacgtg tatagaacgt gtagagatca cgctacccgt 25500 gtacgtgcaa ctggtaatta aaataaaaag taatattcat atgtagtgtc aattttaaat 25560 gatgatgatg aaatggataa tatccatatt gacgatgtca ataatgccgg tattggcata 25620 cagttcatcg atttttagat ttcattcaga ggatgtggaa ttatgttatg ggcatttgta 25680 ttttgatagg atctataatg tagtaaatat aaaatataat ccgcatattc catatagata 25740 taattttatt aatcgcacgt taaccgtaga tgaactagac gataatgtct tttttacaca 25800 tggttatttt ttaaaacaca aatatggttc acttaatcct agtttgattg tctcattatc 25860 aggaaactta aaatataatg atatacaatg ctcagtaaat gtatcgtgtc tcattaaaaa 25920 tttggcaacg agtacatcta ctatattaac atctaaacat aagacttatt ctctacatcg 25980 gtccacgtgt attactataa taggatacga ttctattata tggtataaag atataaatga 26040 catctatgat tttactgcaa tatgtatgct aatagcgtct acattgatag tgaccatata 26100 cgtgtttaaa aaaataaaaa tgaactctta attatgctat gctattagaa atggataaaa 26160 tcaaaattac ggttgattca aa aattggta atgttgttac catatcgtat aacttggaaa 26220 agataactat tgatgtcaca cctaaaaaga aaaaagaaaa ggatgtatta ttagcgcaat 26280 cagttgctgt cgaagaggca aaagatgtca aggtagaaga aaaaaatatt atcgatattg 26340 aagatgacga tgatatggat gtagaaagcg cataatacga tctataaaaa taagtatata 26400 aatacttttt atttactgta ctcttactgt gtagtggtga taccctactc gattattttt 26460 ttaaaaaaaa atacttattc tgattcttct agccatttcc gtgttcgttc gaatgccaca 26520 tcgacgttaa agatagggga gtagttgaaa tctagttctg cattgttggt acgcacctca 26580 aatgtagtgt tggatatctt caacgtatag ttgttgagta gtgatggttt tctaaataga 26640 attctcttca tatcattctt gcacgcgtac atttttagca tccatcttgg aatcctagat 26700 ccttgttcta ttcccaatgg tttcatcaat agaagattaa acatatcgta cgaacacgat 26760 ggagagtaat cgtagcaaaa gtaagcattt cctttaatct cagatcccgg atactggata 26820 tattttgcag ccaacacgtg catccatgca gcatttccta catatacccg gctatgtacc 26880 gcgttatcat cgactgtacg atacataatg ttaccgtgtt gcttacattg ctcgtaaaag 26940 actttcatca atttgtctcc ttctccgtaa attccagtgg gtcttaggca acaagtatac 27000 aattttgctc cattc atgat tacggaatta ttggctttca taaccagttg ctcggccata 27060 cgtttacttt ttgcgtatac atgtcctggt gatatatcat aaagggtatg ctcatggccg 27120 atgaatggat caccgtgttt attgggtcct attgcttcca tgctactagt atagatcaaa 27180 tacttgattc ctaggtccac acaagctgcc aatatagtct gtgttccata atagtttact 27240 ttcatgattt cattatcggt gtattttcca aatacatcca ctagagcagc tgtatgaata 27300 atcagattta ccccatctag cgcttctctt accttatcaa agtcgtttat atcacattgt 27360 atatagttta taaccttaac tttcgaggtt attggttgtg gatcttctac aatatctatg 27420 actctgattt cttgaacatc atctgcacta attaacagtt ttactatata cctgcctaga 27480 aatccggcac caccagtaac cgcgtacacg gccattgctg ccactcataa tatcagacta 27540 cttattctat tttactaaat aatggctgtt tgtataatag accacgataa tatcagagga 27600 gttatttact ttgaaccagt ccatggaaaa gataaagtta ttggattaaa atccggaacg 27660 tatagtttga taattcatcg ttacggagat attagtcaag gatgtgattc cataggcagt 27720 ccagaaatat ttatcggtaa catctttgta aacagatatg gtgtagcata tgtttattta 27780 gatacagatg taaatatatc tacaattatt ggaaaggcgt tatctatttc aaaaaatgat 27840 cagagattag cgtgtggagt tattggtatt tcttacataa atgaaaagat aatacatttt 27900 cttacaatta acgagaatgg cgtttgatat atcagttaat gcgtctaaaa caataaatgc 27960 attagtttac ttttctactc agcaaaataa attagtcata cgtaatgaag ttaatgatac 28020 acactacact gtcgaatttg atagggacaa agtagttgac acgtttattt catataata g 28080 acataatgac tccatagaga taagaggggt gcttccagag gaaactaata ttggttgcgc 28140 ggttaatacg ccggttagta tgacttactt gtataataag tatagtttta aactgatttt 28200 agcagaatat ataagacaca gaaatactat atccggcaat atttattcgg cattgatgac 28260 actagatgat ttggctatta aacagtatgg agacattgat ctattattta atgagaaact 28320 taaagtagac tccgattcgg gactatttga ctttgtcaac tttgtaaagg atatgatatg 28380 ttgtgattct agaatagtag tagctctatc tagtctagta tctaaacatt gggaattgac 28440 aaataaaaaa tataggtgta tggcattagc cgaacatata tctgatagta ttccaatatc 28500 tgagctatct agactacgat acaatctatg taagtatcta cgcgggcaca ctgagagcat 28560 agaggatgaa tttgattatt ttgaagacga tgattcgtct acatgttctg ccgtaaccga 28620 cagggaaacg gatgtataat tttttttata gcgtgaagga tatgataaaa aatataattg 28680 ttgtatttat cccattccaa tcaccttata tgattctgta acacaatgaa ggagtcttat 28740 agatgtatag aggtcagata ctggtttgat aaactgttta ttccacataa gtatgtttga 28800 ctttatggtt agacccgcat actttaacaa atcactgaaa attggagtta ggtattgacc 28860 tctcagaatc agttgccgtt ctggaacatt aaatgtattt tttatgatat a ctccaacgc 28920 atttatgtgg gcatacaaca agtcattact aatggagtat tccaagagaa gagatttcaa 28980 cagactgttt atgaactcga atgccgcctc attgtcgctt atattgatga tgtcgaattc 29040 tcccaatatc atcaccgatg agtagctcat cttgttatcg ggatccaagt tttctaaaga 29100 tgtcattaaa ccctcgatca tgaatggatt tatcatcatc gtttttatgt tggacatgag 29160 cttagtccgt ttgtccacat ctatagacga cgatttctga attatttcat atatccctct 29220 ctttaactcc aggaacttgt caggatggtc tactttaata tgttctcgtc taagagatga 29280 aaatctttgg atggttgcac gcgacttttc tctaaaggat cctctcttaa atgaatccat 29340 cttatccttg gacaagatgg acagtctatt ttccttagat ggtttaatat ttttgttacc 29400 catgatctat aaaggtagac ctaatcgtct cggatgacca tatatttatt ttcagtttta 29460 ttatacgcat aaattgtaaa aaatatgtta ggtttacaaa aatgtctcgt ggggcattaa 29520 tcgtttttga aggattggac aaatctggaa aaacaacaca atgtatgaac atcatggaat 29580 ctataccggc aaacacgata aaatatctta actttcctca gagatccact gtcactggaa 29640 agatgataga tgactatcta actcgtaaaa aaacctataa tgatcatata gttaatctat 29700 tattttgtgc aaatagatgg gagtttgcat cttttataca agaa caacta gaacagggaa 29760 ttactttaat agttgataga tacgcattct ctggagtagc gtatgccgcc gctaaaggcg 29820 cgtcaatgac tctcagtaag agttatgaat ctggattgcc taaacccgac ttagttatat 29880 tcttggaatc tggtagcaaa gaaattaata gaaacgtcgg cgaggaaatt tatgaagatg 29940 ttacattcca acaaaaggta ttacaagaat ataaaaaaat gattgaagaa ggagatattc 30000 attggcaaat tatttcttct gaattcgagg aagatgtaaa gaaggagttg attaagaata 30060 tagttataga ggctatacac acggttactg gaccagtggg gcaactgtgg atgtaatagt 30120 gaaattacat tttttataaa tggatgaagc atattactct ggcaacttgg aatcagtact 30180 cggatacgtg tccgatatgc ataccgaact cgcatcaata tctcaattag ttattgccaa 30240 gatagaaact atagataatg atatattaaa caaggacatt gtaaatttta tcatgtgtag 30300 atcaaacttg gataatccat ttatctcttt cctagatact gtatatacta ttatagatca 30360 agagatctat cagaccgaat tgattaattc attagacgac aatgaaatta tcgattgtat 30420 agttaacaag tttatgagct tttataagga taacctagaa aatatagtag atgctatcat 30480 tactctaaaa tatataatga ataatccaga ttttaaaact acgtatgccg aagtactcgg 30540 ttccagaata gcggatatag atattaaaca agtgata cgt gagaatatac tacaattgtc 30600 taataatatc cgcgaacgat atttgtgaaa atattaaaaa aaaatacttt ttttattaaa 30660 tgacgtcgct tcgcgaattt agaaaattat gctgtgatat atatcacgca tcaggatata 30720 aagaaaaatc taaattaatt agagacttta taacagatag ggatgataaa tatttgatca 30780 ttaagctatt gcttcccgga ttagacgata gaatttataa catgaacgat aaacaaatta 30840 taaaattata tagtataata tttaaacaat ctcaggaaga tatgctacaa gatttaggat 30900 acggatatat aggagacact attaggactt tcttcaaaga gaacacagaa atccgtccac 30960 gagataaaag cattttaact ttagaagaag tggatagttt tttaactacg ttatcatccg 31020 taactaaaga atcgcatcaa ataaaattat tgactgatat cgcatccgtt tgtacatgta 31080 atgatttaaa atgtgtagtc atgcttattg ataaagatct aaaaattaaa gcgggccctc 31140 ggtacgtact taacgctatt agtcctcatg cctatgatgt gtttagaaaa tctaataact 31200 tgaaagagat aatagaaaat gcatctaaac aaaatctaga ctctatatct atttctgtta 31260 tgactccaat taatcccatg ttagcggaat cgtgtgattc tgtcaataag gcgtttaaaa 31320 aatttccatc aggaatgttt gcggaagtca aatacgatgg tgaaagagta caagttcata 31380 aaaataataa cgagtttgcc ttctttagta gaaacatgaa accagtactc tctcataaag 31440 tggattatct caaagaatac ataccgaaag catttaaaaa agctacgtct atcgtattgg 31500 attctgaaat tgttcttgta gacgaacata atgtaccgct cccgtttgga agtttaggta 31560 tacacaaaaa gaaagaatat aaaaactcta acatgtgttt gttcgtgttt gactgtttgt 31620 actttgatgg attcgatatg acggacattc cattgtacga acgaagatct tttctcaaag 31680 atgttatggt tgaaataccc aatagaatag tattctcaga gttgacgaat attagtaacg 31740 agtctcagtt aactgacgta ttggatgatg cactaacgag aaaattagaa ggattggtct 31800 taaaagatat taatggagta tacgaaccgg gaaagagaag atggttaaaa ataaagcgag 31860 actatttgaa cgagggttcc atggcagatt ctgccgattt agtagtacta ggtgcttact 31920 atggtaaagg agcaaagggt ggtatcatgg cagtctttct aatgggttgt tacgacgatg 31980 aatccggtaa atggaagacg gttaccaagt gttcaggaca cgatgataat acgttaaggg 32040 agttgcaaga ccaattaaag atgattaaaa ttaacaagga tcccaaaaaa attccagagt 32100 ggttagtagt taataaaatc tatattcccg attttgtagt agaggatcca aaacaatctc 32160 agatatggga aatttcagga gcagagttta catcttccaa gtcccatacc gcaaatggaa 32220 tatccattag atttcctaga tt tactagga taagagagga taaaacgtgg aaagaatcta 32280 ctcatctaaa cgatttagta aacttgacta aatcttaata gttacataca aattaaaata 32340 acactattta gttggtggtc gccatggatg gtgttattgt atactgtcta aacgcgttag 32400 taaaacatgg cgaggaaata aatcatataa aaaatgattt catgattaaa ccatgttgtg 32460 aaaaagtcaa gaacgttcac attggcggac aatctaaaaa caatacagtg attgcagatt 32520 tgccatatat ggataatgcg gtatccgatg tatgcaattc actgtataaa aagaatgtat 32580 caagaatatc cagatttgct aatttgataa agatagatga cgatgacaag actcctactg 32640 gtgtatataa ttattttaaa cctaaagatg ccattcctgt tattatatcc ataggaaagg 32700 atagagatgt ttgtgaacta ttaatctcat ctgataaagc gtgtgcgtgt atagagttaa 32760 attcatataa agtagccatt cttcccatgg atgtttcctt ttttaccaaa ggaaatgcat 32820 cattgattat tctcctgttt gatttctcta tcgatgcggc acctctctta agaagtgtaa 32880 ccgataataa tgttattata tctagacacc agcgtctaca tgacgagctt ccgagttcca 32940 attggttcaa gttttacata agtataaagt ccgactattg ttctatatta tatatggttg 33000 ttgatggatc tgtgatgcat gcaatagctg ataatagaac ttacgcaaat attagcaaaa 33060 atatattaga caata ctaca attaacgatg agtgtagatg ctgttatttt gaaccacaga 33120 ttaggattct tgatagagat gagatgctca atggatcatc gtgtgatatg aacagacatt 33180 gtattatgat gaatttacct gatgtaggcg aatttggatc tagtatgttg gggaaatatg 33240 aacctgacat gattaagatt gctctttcgg tggctggtat ttggaaagtt ttataggtag 33300 ttgatagaac aaaatacata attttgtaaa aataaatcac tttttatact aatatgacac 33360 gattaccaat acttttgtta ctaatatcat tagtatacgc tacacctttt cctcagacat 33420 ctaaaaaaat aggtgatgat gcaactttat catgtaatcg aaataataca aatgactacg 33480 ttgttatgag tgcttggtat aaggagccca attccattat tcttttagct gctaaaagcg 33540 acgtcttgta ttttgataat tataccaagg ataaaatatc ttacgactct ccatacgatg 33600 atctagttac aactatcaca attaaatcat tgactgctag agatgccggt acttatgtat 33660 gtgcattctt tatgacatcg cctacaaatg acactgataa agtagattat gaagaatact 33720 ccacagagtt gattgtaaat acagatagtg aatcgactat agacataata ctatctggat 33780 ctacacattc accggaaact agttctgaga aacctgatta tatagataat tctaattgct 33840 cgtcggtatt cgaaatcgcg actccggaac caattactga taatgtagaa gatcatacag 33900 acaccgtc ac atacactagt gatagcatta atacagtaag tgcatcatct ggagaatcca 33960 caacagacga gactccggaa ccaattactg ataaagaaga agatcataca gttacagaca 34020 ctgtctcata cactacagta agtacatcat ctggaattgt cactactaaa tcaaccaccg 34080 atgatgcgga tctttatgat acgtacaatg ataatgatac agtaccatca actactgtag 34140 gcggtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa atatttggta 34200 ttaccgcatt aattatattg tcggccgtgg caatattctg tattacatat tatatatata 34260 ataaacgttc acgtaaatac aaaacagaga acaaagtcta gatttttgac ttacataaat 34320 gtctgggata gtaaaatcta tcatattgag cgggccatct ggtttaggaa agacagccat 34380 agccaaaaga ctatgggaat atatttggat ttgtggtgtc ccataccact agatttcctc 34440 gtcctatgga acgagaaggt gtcgattacc attacgttaa cagagaggcc atctggaagg 34500 gaatagccgc cggaacatac tgagttttta ggaaatattt acggaacttc taaaactgct 34560 gtgaatacag cggctattaa taatcgtatt tgtgtgatgg atctaaacat cgacggtgtt 34620 agaagtttta aaaatactta cctaatgcct tactcggtgt atataagacc tacctctctt 34680 aaaatggttg agaccaagct tcgttgtaga aacactgaag cggatgatga gattcatcgt 34740 cgtgtgatgt tggcaaaaac tgacatggat gaggcaggtg aagccggtct attcgacact 34800 attatcattg aagatgatgt gaatttagca tatagtaagt taattcagat actacaggac 34860 cgtattagaa tgtattttaa cactaattag agacttaaga cttaaaactt gataattaat 34920 aatataactc gtttttatat gtggctattt caacgtctaa tgtattagtt aaatattaaa 34980 acttaccacg taaaacttaa aatttaaaat gatatttcat tgacagatag atcacacatt 35040 atgaactttc aaggacttgt gttaactgac aattgcaaaa atcaatgggt cgttggacca 35100 ttaataggaa aaggtggatt tggtagtatt tatactacta atgacaataa ttatgtagta 35160 aaaatagagc ccaaagctaa cggatcatta tttaccgaac aggcatttta tactagagta 35220 cttaaaccat ccgttatcga agaatggaaa aaatctcaca atataaagca cgtaggtctt 35280 atcacgtgca aggcatttgg tctatacaaa tccattaatg tggaatatcg attcttggta 35340 attaatagat taggtgcaga tctagatgcg gtgatcagag ccaataataa tagattacca 35400 aaaaggtcgg tgatgttgat cggaatcgaa atcttaaata ccatacaatt tatgcacgag 35460 caaggatatt ctcacggaga tattaaagcg agtaatatag tcttggatca aatagataag 35520 aataaattat atctagtgga ttacggattg gtttctaaat tcatgtctaa tggcgaaca t 35580 gttccattta taagaaatcc aaataaaatg gataacggta ctctagaatt tacacctata 35640 gattcgcata aaggatacgt tgtatctaga cgtggagatc tagaaacact tggatattgt 35700 atgattagat ggttgggagg tatcttgcca tggactaaga tatctgaaac aaagaattgt 35760 gcattagtaa gtgccacaaa acagaaatat gttaacaata ctgcgacttt gttaatgacc 35820 agtttgcaat atgcacctag agaattgctg caatatatta ccatggtaaa ctctttgaca 35880 tattttgagg aacccaatta cgacaagttt cggcacatat taatgcaggg tgtatattat 35940 taagtgtggt gtttggttga tgtaaaattt ttgtcgataa aaattaaaaa ataacttaat 36000 ttattattga tctcgtgtgt acaaccgaaa tcatggcgat gttttacgca cacgctctcg 36060 gtgggtacga cgagaatctt catgcctttc ctggaatatc atcgactgtt gccaatgatg 36120 tcagtttata ataacaagta tgacattgta aaagacaaat atatgtggtg ttacagtcag 36180 gtgaacaaga gatatattgg agcactgctg cctatgtttg agtgcaatga atatctacaa 36240 attggagatc cgatccatga tcaagaagga aatcacatat cgccacaaaa actactatgc 36300 tctaagcgga atcgggtacg agagtctaga cttgtgtttg gaaggagtag ggattcatca 36360 tcacgtactt gaaacagaaa acgctgtata tggaaaagtt caacatgatt a ttctactat 36420 caaagagaag gccaaagaaa tgaatgcact cagttcagga cctatcatcg attaccacgt 36480 ctggatagga gattgtatct gtcaagttac tgctgtggac gtacatggaa aggaaattat 36540 gagaatgaga ttcaaaaagg gtgcggtgct tccgatccca aatctggtaa aagttaaact 36600 tggggagaat gatacagaaa atctttcttc tactatatcg gcggcaccat cgaggtaacc 36660 acctctctgg aagacagtgt gaatcatgta ctcatgaaac gtttggaatc tatacgccat 36720 atgtggtctg ttgtatatga tcattttgat attgtgaatg gtaaagaatg ctgttatgtg 36780 catacgcatt tgtctaatca aaatcttata ccgagtactg taaaaacaaa tttgtacatg 36840 aagactatgg gatcatgcat tcaaatgagt atcttagcga actgaaggaa tcaggtggat 36900 ggagtcccag accagaaatg caggaatttg aatatccaga tggagtggaa gacactgaat 36960 caattgagag attggtagag gagttcttca atagatcaga acttcaggct ggtaaatcta 37020 ttaatgttaa acatacatct gtttcagcta agcaactaag aacacgtata ctctcatctt 37080 ttgccaacac agagggtgga tatttgttca ttggagttga taataataca cacaaagtat 37140 ttggattcac ggtgggttac gactacctca gactgataga gaatgatata gaaaagcata 37200 tcaaaagact ttgtgttgtg tatttctgtg agaagaaaga ggac atcaag tacacgtgtc 37260 gattcatcaa ggtatataaa cctggggatg aggctacctc gacatacgtg tgcgctatca 37320 aagtggaaag atgctgttgt gctgtgtttg cagattggcc agaatcatgg tatcaagaag 37380 tattctccag atgaataggt gtcacatata aaattttaat taatgtaact atagagaaca 37440 aataataggt tgtaatatca tatagacaat aactaacaat taattagtaa ctgttatctc 37500 tttttaacta actaactata cctattaata catcgtaatt atagttctta acatctatta 37560 atcattgatt cgcttcttta attttttata aaccaacatt gttaattgaa aagggataac 37620 atgttacaga atataaatta tatatggatt ttttttaaaa aggaaatact tgactggagt 37680 gtatatttat ctcttcatta tatagcacgc gtgttttcca atttttccac atcccatata 37740 atacaggatt ataatctcgt tcgaacatac gagaaagtgg ataaaacaat agttgatttt 37800 ttatctaggt tgccaaattt attccatatt ttagaatatg gggaaaatat tctacatatt 37860 tattctatgg atgatgctaa tacgaatatt ataatttttt ttctagatag agtattaaat 37920 attaataaga acgggtcatt tatacacaat ctcaggttat catcatccat taatataaaa 37980 gaatatgtat atcaattagt taataatgat catccagata ataggataag actaatgctt 38040 gaaaatggac gtagaacaag acattttttg tcctata tat cagatacagt taatatctat 38100 atatgtattt tatatagatg ccgaagacag ttacggttgt acattattac atagatgtat 38160 atatcactat aagaaatcag aatcagaatc agaatcatac aatgaattaa ttaagatatt 38220 gttaaataat ggatcagatg tagataaaaa agatacgtac ggaaacacac cttttatcct 38280 attatgtaaa cacgatatca acaacgtgga attgtttgag atatgtttag agaatgctaa 38340 tatagactct gtagacttta atagatatac acctcttcat tatgtctcat gtcgtaataa 38400 atatgatttt gtaaagttat taatttctaa aggagcaaat gttaatgcgc gtaataaatt 38460 cggaactact ccattttatt gtggaattat acacggtatc tcgcttataa aactatattt 38520 ggaatcagac acagagttag aaatagataa tgaacatata gttcgtcatt taataatttt 38580 tgatgctgtt gaatctttag attatctatt atccagagga gttattgata ttaactatcg 38640 tactatttac gacgctgtca gttataatgc gtataatacg ttggtctatc tattaaacag 38700 aaatggtgat tttgagacga ttactactag tggatgtaca tgtatttcgg aagcagtcgc 38760 aaacaacaac aaaataataa tggaagtact attgtctaaa cgaccatctt tgaaaattat 38820 gatacagtct atgatagcaa ttactaaaca taaacagcat aatgcagatt tattgaaaat 38880 gtgtataaaa tatactgcgt gtatgaccga ttatgatact cttatagatg tacaatcact 38940 acagcaatat aaatggtata ttttaagatg tttcgatgaa atagatatca tgaagagatg 39000 ttatataaaa aataaaactg tattccaatt agttttttgt atcaaagaca ttaatacttt 39060 aatgagatac ggtaaacatc cttctttcgt gaagtgcact agtctcgacg tatacggaag 39120 tcgtgtacgt aatatcatag catctattag atatcgtcag agattaatta gtctattatc 39180 caagaagctg gatcctggag ataaatggtc gtgttttcct aacgaaataa aatataacga 39240 taacgaactg tccacatatc taaaaatctt ataaacacta ttaaaatata aaatcacact 39300 acatcattgt ttccttttag tgctcgacag tgtatactat ttttaacgct cataaataaa 39360 aatgaaaacg atttccgttg ttacgttgtt atgcgtacta cctgctgttg tttattcaac 39420 atgtactgta cccactatga ataacgctaa attaacgtct accgaaacat cgtttaataa 39480 taaccagaaa gttacgttta catgtgatca gggatatcat tcttcggatc caaatgctgt 39540 ctgcgaaaca gataaatgga aatacgaaaa tccatgcaaa aaaatgtgca cagtttctga 39600 ttacatctct gaactatata ataaaccgct atacgaagtg aattccacca tgacactaag 39660 ttgcaacggc gaaacaaaat attttcgttg cgaagaaaaa aatggaaata cttcttggaa 39720 tgatactgtt acgtgtccta at gcggaatg tcaacctctt caattagaac acggatcgtg 39780 tcaaccagtt aaagaaaaat actcatttgg ggaatatata actatcaact gtgatgttgg 39840 atatgaggtt attggtgctt cgtacataag ttgtacagct aattcttgga atgttattcc 39900 atcatgtcaa caaaaatgtg atataccgtc tctatctaat ggattaattt ccggatctac 39960 attttctatc ggtggcgtta tacatcttag ttgtaaaagt ggttttatac taacgggatc 40020 tccatcatcc acatgtatcg acggtaaatg gaatcccata ctcccaacat gtgtacgatc 40080 taacgaaaaa tttgatccag tggatgatgg tcccgacgat gagacagatt tgagcaaact 40140 ctcgaaagac gttgtacaat atgaacaaga aatagaatcg ttagaagcaa cttatcatat 40200 aatcatagtg gcgttaacaa ttatgggcgt catattttta atctccgtta tagtattagt 40260 ttgttcctgt gacaaaaata atgaccaata taagttccat aaattgctac cgtgaatata 40320 aatccgttaa aataatgaat aattaataat taataattta ataacaaaca agtatcaaaa 40380 gattaaagac ttatagctag aatcaattga gatgtcttct tcagtggatg ttgatatcta 40440 cgatgccgtt agagcatttt tactcaggca ctattataac aagagattta ttgtgtatgg 40500 aagaagtaac gccatattac ataatatata caggctattt acaagatgcg ccgttatacc 40560 gttcgatgat atagt acgta ctatgccaaa tgaatcacgt gttaaacaat gggtgatgga 40620 tacacttaat ggtataatga tgaatgaacg cgatgtttct gtaagcgttg gcaccggaat 40680 actattcatg gaaatgtttt tcgattacaa taaaaatagt atcaacaatc aactaatgta 40740 tgatataatt aatagcgtat ctataattct agctaatgag agatatagaa gcgcttttaa 40800 cgacgatggt atatacatcc gtagaaatat gattaacaag ttgtacggat acgcatctct 40860 aactactatt ggcacgatcg ctggaggtgt ttgttattat ctgttgatgc atctagttag 40920 tttgtataaa taattatttc aatatactag ttaaaatttt aagattttaa atgtataaaa 40980 aactaataac gtttttattt gtaataggtg cattagcatc ctattcgaat aatgagtaca 41040 ctccgtttaa taaactgagt gtaaaactct atatagatgg agtagataat atagaaaatt 41100 catatactga tgataataat gaattggtgt taaattttaa agagtacaca atttctatta 41160 ttacagagtc atgcgacgtc ggatttgatt ccatagatat agatgttata aacgactata 41220 aaattattga tatgtctact attcaacgca gaggtcacac gtgtagaata tctaccaaat 41280 tatcatgcca ttatgataag tacccttata ttcacaaata tgatggtgat gagcgacaat 41340 attctattac tgcagaggga aaatgctata aaggaataaa atatgaaata agtatgatca 41400 acgatgatac tctattgaga aaacatactc ttaaaattgg atctacttat atatttgatc 41460 gtcatggaca tagtaataca tattattcaa aatatgattt ttaaaaattt aaaatatatt 41520 atcacttcag tgacagtagt caaataacaa acaacaccat gagatatatt ataattctcg 41580 cagttttgtt cattaatagt atacacgcta aaataactag ttataagttt gaatccgtc a 41640 attttgattc caaaattgaa tggactgggg atggtctata caatatatcc cttaaaaatt 41700 atggcatcaa gacgtggcaa acaatgtata caaatgtacc agaaggaaca tacgacatat 41760 ccgcatttcc aaagaatgat ttcgtatctt tctgggttaa atttgaacaa ggcgattata 41820 aagtggaaga gtattgtacg ggaccaccga ctgtaacatt aactgaatac gacgaccatc 41880 cgtatgctac tagaggtagc aaaaagattc ctatttacaa acgcggtgac atgtgtgata 41940 tctacttgtt gtatacggct aacttcacat tcggagattc taaagaacca gtaccatatg 42000 atatcgatga ctacgattgc acgtctacag gttgcagcat agactttgtc acaacagaaa 42060 aagtgtgcgt gacagcacag ggagccacag aagggtttct cgaaaaaatt actccatgga 42120 gttcgaaagt atgtctgaca cctaaaaaga gtgtatatac atgcgcaatt agatccaaag 42180 aagatgttcc caatttcaag gacaaaatgg ccagagttat caagagaaaa tttaactaaa 42240 tttctcggta gcacatcaaa tgatgttacc acttttctta gcatgcttaa cttgactaaa 42300 tattcataac taatttttat taatgataca aaaacgaaat aaaactgcat attatacact 42360 ggttaacgcc cttataggct ctaaccattt tcaagatgag gtccctgatt atagtccttc 42420 tgttcccctc tatcatctac tccatgtcta ttagacgatg tgagaagact g aagaggaaa 42480 catggggatt gaaaataggg ttgtgtataa ttgccaaaga tttctatccc gaaagaactg 42540 attgcagtgt tcatctccca actgcaagtg aaggcaatgg attcagggat atacgaaaca 42600 ccgataaatt ataaaaaaag caatgtgtcc gctgtttccg ttaataatac tattttcgta 42660 actggcggat tattcataaa taactctaat agcacgatcg tggttaacaa tatggaaaaa 42720 cttgacattt ataaagacaa acaatggtcg attatagaaa tgcctatggc tagggtatat 42780 cacggcatcg actcgacatt tggaatgtta tattttgccg gaggtctatc cgttaccgaa 42840 caatatggta atttagagaa aaacaacgag atatcttgtt acaatcctag aacgaataag 42900 tggtttgata tttcatatac tatttataag atatccatat catcattgtg taaactaaat 42960 aacgtcttct atgtatttag taaggacatt ggatatgtgg aaaagtatga tggtctcccc 43020 gctataaagg cattatcaac ttctccttat tgattgaaaa tgaaaatata aatagttttt 43080 atgtatagca gtattaccct atagttttat tgcttactac taacatggat acagatacag 43140 atgttacaaa tgtagaagat atcatgaatg aaatagatag agagaaagaa gaaatactaa 43200 aaaatgtaga aattgaaaat aataaaaaca ttaacaagaa tcatcccaat gaatatatta 43260 gagaagcact cgttattaat acaagtagta atagtgattc catt gataaa gaagttatag 43320 aatgtatcag tcacgatgta ggaatataga tcatatctac taatttttat aatcaataca 43380 aaacataaaa aacaactcgt tattacatag caggcatgga atccttcaag tattgttttg 43440 ataacgatgg caagaaatgg attatcggaa atactttata ttctggtaat tcaatactct 43500 ataaggtcag aaaaaatttc actagttcgt tctacaatta cgtaatgaag atagatcaca 43560 aatcacacaa gccattgttg tctgaaatac gattctatat atctgtattg gatcctttga 43620 ctatcgacaa ctggacacgg gaacgtggta taaagtattt ggctattcca gatctgtatg 43680 gaattggaga aaccgatgat tatatgttct tcgttataaa gaatttggga agagtattcg 43740 ccccaaagga tactgaatca gtcttcgaag catgcgtcac tatgataaac acgttagagt 43800 ttatacactc tcgaggattt acccatggaa aaatagaacc gaggaatata ctgattagaa 43860 ataaacgtct ttcactaatt gactattcta gaactaacaa actatacaag agtggaaact 43920 cacatataga ttacaacgag gacatgataa cttcaggaaa tatcaattat atgtgtgtag 43980 acaatcatct tggagcaaca gtttcaaaac gaggagattt agaaatgttg ggatattgca 44040 tgatagaatg gttcggtggc aaacttccat ggaaaaacga aagtagtata aaagtaataa 44100 aacaaaaaaa agaatataaa aaatttatag ctacttt ctt tgaggactgt tttcctgaag 44160 gaaatgaacc tctggaatta gttagatata tagaattagt atacacgtta gattattctc 44220 aaactcctaa ttatgacaga ctacgtagac tgtttataca agattgaaat attctttttt 44280 tatagagtgt ggtagtgtta cggatatcta atattaatat tagactatct ctatcgcgct 44340 acacgaccaa tatcgattac tatggatatc ttctatgaaa ggagagaatg tattcatttc 44400 tccagcgtca atctcgtcag tattgacaat actgtattat ggagctaatg gatccactgc 44460 tgaacagcta tcaaaatatg tagaaaagga ggagaacacg gataaggtta gcgctcagaa 44520 tatctcattc aaatccatga ataaagtata tgggcgatat tctgccgtgt ttaaagattc 44580 ctttttgaga aaaattggcg ataagtttca aactgttgac ttcactgatt gtcgcactat 44640 agatgcaatc aacaagtgtg tagatatctt tactgagggg aaaatcaatc cactattgga 44700 tgaacaattg tctcctagca attagtgccg tatactttaa agcaaaatgg ttgacgccat 44760 tcgaaaagga atttaccagt gattatccct tttacgtatc accaacggaa atggtagacg 44820 taagtatgat gtctatgtac ggcgagctat ttaatcacgc atctgtaaaa gaatcattcg 44880 gtaacttttc aatcatagaa ctgccatatg ttggagatac tagtatgatg gtcattcttc 44940 cagacaagat tgatggatta gaatccatag aacaaaatct aacagataca aattttaaga 45000 aatggtgtaa ctctctggaa gctacgttta tcgatgttca cattcccaag tttaaggtaa 45060 caggctcgta taatctggtg gatactctag taaagtcagg actgacagag gtgttcggtt 45120 caactggaga ttatagcaat atgtgtaatt tagatgtgag tgtcgacgct atgatccaca 45180 aaacgtatat agatgtcaat gaagagtata cagaagcagc tgcagcaact tgtgcactgg 45240 tgtcagactg tgcatcaaca attacaaatg agttctgtgt agatcatccg ttcatctatg 45300 tgattaggca tgttgatgga aaaatttttt tcgttggtag atattgctct ccgacaacta 45360 attgttaacc atttttttta aaaaaataga aaaaacatgt ggtattagtg caggtcgtta 45420 ttcttccaat tgcaattggt aagatgacgg ccaactttag tacccacgtc ttttcaccac 45480 agcactgtgg atgtgacaga ctgaccagta ttgatgacgt caaacaatgt ttgactgaat 45540 atatttattg gtcgtcctat gcataccgca acaggcaatg cgctggacaa ttgtattcca 45600 cactcctctc ttttagagat gatgcggaat tagtgttcat cgacattcgc gagctggtaa 45660 aaaatatgcc gtgggatgat gtcaaagatt gtgtagaaat catccgttgt tatataccgg 45720 atgagcaaaa aaccatcatc ggactttgtg catatgctgc tacttactgg ggaggtgaag 45780 accatcccac tagtaacagt ct gaacgcat tgtttgtgat gcttgagatg ctaaattacg 45840 tggattataa catcatattc cggcgtatga attgatgagt tgtacatctt gacattttct 45900 tctttcttct cttctccctt tcccagaaac aaactttttt tacccactat aaaataaaat 45960 gagtatacta cctgttatat ttctttctat atttttttat tcttcattcg ttcagacttt 46020 taacgcgcct gaatgtatcg acaaagggca atattttgca tcattcatgg agttagaaaa 46080 cgagccagta atcttaccat gtcctcaaat aaatacgcta tcatccggat ataatatatt 46140 agatatttta tgggaaaaac gaggagcgga taatgataga attataccga tagataatgg 46200 tagcaatatg ctaattctga acccgacaca atcagactct ggtatttata tatgcattac 46260 cacgaacgaa acctactgtg acatgatgtc gttaaatttg acaatcgtgt ctgtctcaga 46320 atcaaatata gatcttatct cgtatccaca aatagtaaat gagagatcta ctggcgaaat 46380 ggtatgtccc aatattaatg catttattgc tagtaacgta aacgcagata ttatatggag 46440 cgggcatcga cgccttagaa ataagagact taaacaacgg acacctggaa ttattaccat 46500 agaagatgtt agaaaaaatg atgctggtta ttatacatgt gttttagaat atatatacgg 46560 tggcaaaaca tataacgtaa ccagaattgt aaaattagag gtacgggata aaataatacc 46620 ttctactatg caatt accag aaggtgttgt aacttcaata ggtagtaatt tgactattgc 46680 gtgtagagta tcgttgagac ctcccacaac ggatgcagac gtcttttgga taagtaatgg 46740 tatgtattac gaagaagatg atggggacgg agacggtaga ataagtgtag caaataaaat 46800 ctatatgacc gataagagac gtgttattac atcccggtta aacattaatc ctgtcaagga 46860 agaagatgct acaacgttta cgtgtatggc gtttactatt cctagcatca gcaaaacagt 46920 tactgttagt ataacgtgaa tgtatgttgt tacatttcca tgtcaattga gtttataaga 46980 atttttatac attatcttcc aacaaacaat tgacgaacgt attgctatga ttaactccca 47040 cgatactatg catattatta atcattaact tgcagactat acctagtgct attttgacat 47100 actcatgttc ttgtgtaatt gcggtatcta tattattaaa gtacgtaaat ctagctatag 47160 ttttattatt taattttaga taatataccg tctccttatt tttaaaaatt gccacatcct 47220 ttattaaatc atgaatggga atttctatgt catcgttaat atattgtgaa caacaagagc 47280 agatatctat aggaaagggt ggaatgcgat acattgatct atgtagtttt aaaacacacg 47340 cgaactttga agaatttata taaatcattc catcgataca tccttctatg ttgacatgta 47400 tatatccagg aattctttta ttaatgtcag gaaatgtata aactaaaaca ttgcccgaaa 47460 gcggtgcc tc tatctgcgtt atatccgttc ttaacttaca aaatgtaacc aatacctttg 47520 catgacttgt tttgttcggc aacgttagtt taaacttgac gaatggatta attacaatag 47580 catgatccgc gcatctatta agttttttta ctttaacgcc cttgtatgtt tttacagaga 47640 ctttatctaa atttctagtg cttgtatgtg ttataaatat aacgggatat agaactgaat 47700 cacctacctt agatacccaa ttacatttta tcagatccag ataataaaca aattttgtcg 47760 ccctaactaa ttctatattg ttatatattt tacaattggt tatgatatca tgtaataact 47820 tggagtctaa cgcgcatcgt cgtacgttta tacaattgtg atttagtgta gtatatctac 47880 acatgtattt ttccgcacta tagtattctg gactagtgat aaaactatcg ttatatctgt 47940 cttcaatgaa ctcatcgaga tattgctctc tgtcatattc atacacctgc ataaactttc 48000 tagacatctt acaatccgtg ttattttagg atcatattta catatttacg ggtatatcaa 48060 agatgttaga ttagttaatg ggaatcgtct ataataatga atattaaaca attatatgag 48120 gacttttacc acaaagcatc ataaaaatga gtcgtcgtct gatttatgtt ttaaatatca 48180 accgcgaatc aactcataaa atacaagaga atgaaatata tacatatttt agtcattgca 48240 atatagacca tacttctaca gaacttgatt ttgtagttaa aaactatgat ctaaacagac 48300 gacaacctgt aactgggtat actgcactac actgctattt gtataataat tactttacaa 48360 acgatgtact gaagatatta ttaaatcatg gagtggatgt aacgatgaaa accagtagcg 48420 gacgtatgcc tgtttatata ttgcttacta gatgttgtaa tatttcacat gatgtagtga 48480 tagatatgat agacaaagat aaaaaccact tatcgcatag agactattcc aacctactac 48540 tagagtatat aaaatctcgt tacatgttat tgaaggaaga ggatatcgat gagaacatag 48600 tatccacttt attagataag ggaatcgatc ctaactttaa acaagacgga tatacagcgt 48660 tacattatta ttatttgtgt ctcgcacacg tttataaacc aggtgagtgt agaaaaccga 48720 taacgataaa aaaggccaag cgaattattt ctttgtttat acaacatgga gctaatctaa 48780 acgcgttaga taattgtggt aatacaccat tccatttgta tcttagtatt gaaatgtgta 48840 ataatattca tatgactaaa atgctgttga cttttaatcc gaatttcaaa atatgtaata 48900 atcatggatt aacgcctata ctatgttata taacttccga ctacatacaa cacgatattc 48960 ttgttatgtt aatacatcac tatgaaacaa atgttggaga aatgccgata gatgagcgtc 49020 gtataatcgt attcgagttt atcaaaacat attctacacg tccggcagat tcgataactt 49080 atttgatgaa taggtttaaa aatatagata tttatacccg ctatgaagga aagacatta t 49140 tacacgtagc atgtgaatat aataatacac acgtaataga ttatcttata cgtatcaacg 49200 gagatataaa tgcgttaacc gacaataaca aacacgctac acaactcatt atagataaca 49260 aagaaaattc cccatatacc attaattgtt tactgtatat acttagatat attgtagata 49320 agaatgtgat aagatcgttg gtggatcaac ttccatctct acctatcttc gatataaaat 49380 catttgagaa attcatatcc tactgtatac ttttagatga cacattttac aatagacacg 49440 ttaggaatcg caattctaaa acgtatcgat acgcattttc aaaatacatg tcgtttgata 49500 aatacgatgg tataataact aaatgtcata aagaaacaat attgctcaaa ctatccactg 49560 ttctagacac tacactatat gcagttttaa gatgccataa ttcgaaaaag ttaagaagat 49620 acctcaacga gttaaaaaaa tataataacg ataagtcctt taaaatatat tctaatatta 49680 tgaatgagag ataccttaat gtatattata aagatatgta cgtgtcaaag gtatatgata 49740 aactatttcc tgttttcaca gataaaaatt gtctactaac attactacct tcagaaatta 49800 tatacgaaat attatacatg ctgacaatta acgatcttta taatatatcg tatccaccta 49860 ccaaagtata gttgtatttt tctcatgcga tgtgtgtaaa aaaactgata ttatataaat 49920 attttagtgc cgtataatga agatgacgat gaaaatgatg gtacatatat a tttcgtatc 49980 attattgtta ttgctattcc acagttacgc catagacatc gaaaatgaaa tcacagaatt 50040 cttcaataaa atgagagata ctctaccagc taaagactct aaatggttga atccagcatg 50100 tatgttcgga ggcacaatga atgatatagc cgctctagga gagccattca gcgcaaagtg 50160 tcctcctatt gaagacagtc ttttatcgca cagatataaa gactatgtgg ttaaatggga 50220 gaggctagaa aaaaatagac ggcgacaggt ttctaataaa cgtgttaaac atggtgattt 50280 atggatagcc aactatacat ctaaattcag taaccgtagg tatttgtgta ccgtaactac 50340 aaagaatggt gactgtgttc agggtatagt tagatctcat attaaaaaac ctccttcatg 50400 cattccaaaa acatatgaac taggtactca tgataagtat ggcatagact tatactgtgg 50460 aattctttac gcaaaacatt ataataatat aacttggtat aaagataata aggaaattaa 50520 tatcgacgat attaagtatt cacaaacggg aaagaaatta attattcata atccagagtt 50580 agaagatagt ggaagataca actgttacgt tcattacgac gacgttagaa tcaagatgta 50640 aaatacttac ggttataccg tcgcaagacc acaggtttaa actaatacta gatccaaaaa 50700 tcaacgtaac gataggagaa cctgccaata taacatgcac tgctgtgtca acgtcattat 50760 tgattgacga tgtactgatt gaatgggaaa atccatccgg atgg cttata ggattcgatt 50820 ttgatgtata ctctgtttta actagtagag gcggtatcac cgaggcgacc ttgtactttg 50880 aaaatgttac tgaagaatat ataggtaata catataaatg tcgtggacac aactattatt 50940 ttgaaaaaac ccttacaact acagtagtat tggagtaaat acacaatgca tttttatata 51000 cattactgaa taattattat tattatttat atcgtatttg tgctataacg cgactatcta 51060 ggtatttgta tctcaccgat agagaacata taaatgtaga ctctattaaa cagttgtgta 51120 aaatatcaga tcctaataga tgtggatgta cggctttaga aatgagttca ttaaaatatg 51180 tgatatcaac ggaacatatt tatataatta tactattgct gttagtataa ttattgattc 51240 cacggaagaa ctaccaacag ttactccaat tacaacaaca tataattata ctatcgatga 51300 tagcactact gaagaactac aagtgactcc tcatatggat ctccatcgat gatacatgta 51360 ttaaaatact ttccgaataa gtcttttaaa tattgtatta attatgaaaa actatgctat 51420 gcgagtatga tacgatacta gattttatct ctagcgagag atgtcgttag aatcatttat 51480 caacgaatat cgataacatg tgtcatttat acgttaaagt ctgtccgtct tctctattgt 51540 ttagactgtt tgtagaatgc tgtgatataa acaaactagt agacacaaat atttaactca 51600 tgatgaagtt gagaatgata tgctttagct aatataa aaa tatattaatc cactatatat 51660 tctagacttg atttaaaacc gataaactac tactacgtac tgtataagtt aggagcagac 51720 cctaattatg tagatgatag aggtaatact tctgcatcta tatgtccact tatgagaaaa 51780 cgtcatttaa taagatgcat cgtgaaaaga aatttattaa agagttggta aaatatgaaa 51840 ccgaaagtaa ataatatagg aaatacacct ctacataact acgtatctca atatgatatc 51900 actctcattc ctcatccaca acccattaaa aaatggaaat taaagccctc tattagcata 51960 aacggctaca ggtctacctt tacaatggcc tttccttgtg cccagttcag accctgtcat 52020 tgccacgcta ctaaggactc cctgaatacc gtggccgacg tcagacattg tctgactgaa 52080 tacatcctgt gggtttctca tagatggacc catagagaaa gcgcagggtc tctctacagg 52140 cttctcatct ctttcagaac tgatgcaacg gagctctttg gtggtgagtt gaaggattca 52200 cttccgtgga gatcattaaa tgactccatg aaaaccgccg aagaacttcg tgcaatcatt 52260 ggactttgta ctcaatcagc tatcgtctct ggaagagtct tcaacgataa gtatatcgac 52320 atactactta tgctgcgaaa gattctgaac gagaacgact atctcaccct cttggatcat 52380 atccgcactg ctaaatacta aatctccttc atgctctctc actacacttt ttatcatctt 52440 atgaggaata attagcacca gaatagctat ggattgcaca tgtattctat gtcgtctact 52500 ggatgaagat gtgacgtaca aaaaaataaa actagaaatt gaaacgtgtc acaacttatc 52560 aaaacatata gatagacgag gaaacaatgc gctacattgt tacgtctcca ataaatgcga 52620 tacagacatt aagattgttc gactgttact ctctcgcgga gtcgagagac tttgtagaaa 52680 caacgaagga ttaactccgc taggagcata cagtaagcat agatacgtaa aatctcagat 52740 tgtgcatcta ctgatatcca gctattcgaa ttcctctaac gaactcaagt cgaatataaa 52800 tgatttcgac ttacgtctgc taaaatacct aattgtggat aaacggatac gtccgtccaa 52860 gaatacgaat tatgcaatca atggtctcgg attggtggat atatacgtaa cgacgcctaa 52920 tccgagacca gaagtattgc tatggcttct taaatcagaa tgttacagca ccggttacgt 52980 atttcgtacc tgtatgtaca acagtgatat gtgtaagaac tctcttcatt actatatatc 53040 gtctcataga gaatctctat ccaaggatgt aattaaatgt ttgatcgata acaatgtttc 53100 catccaatac tactggtctt gctcaaccat agatatagag attattaata aaggatgtgg 53160 acacgtgtag agtatacgac gtcagcccta tattagaggc gtattatcta aacaagcgat 53220 ttagagtaac cccatataat gtagacatgg aaatcgttaa tcttcttatt gagagacgtc 53280 atactcttgt cgacgtaatg cg tagtatta cttcgtacga ttccagagaa tataaccact 53340 acatcatcga taacattcta aagagattta gacaacagga tgaatccatc gtacaagcca 53400 tactgataaa ctacttacat tacggcgata tggtaagtat acctatcatt caatgcatgt 53460 tggataagac gacggacaac aactttgtta ataataatct cgtcgatgta aacgtcgtaa 53520 ggtttatcgt ggaaaatatg gacacgcggc tgtaaatcac atatctaaca atggccgtct 53580 atgtatgtac ggtctgatat tatcgagatt taataattgc gggtatcact gttatgaaga 53640 tgtatttgat atactaagca agtacatgga tgatatagat atgatcgata actctactat 53700 attacgcggt cgatgtcaat aatatacaat ttgcaaagcg gttattggaa tatggagcga 53760 gtgtcacgct cgataatcaa tacggccatc cagaaaagca gttaccaaag agaagctagt 53820 tgatttatta ctgagttacc atcccactct agagactatg attgacgcat ttaatagaga 53880 tatacgctat ctatatcctg aaccattatt cgcctgtatc agatacgcct taatcctaga 53940 tgatgatttt ccttctaaag taagtatgat atcgccggtc gtcataagga actaaagcgc 54000 tatagagcag acattaatag aatgaagaat gcctacatat caggcgtctc catgtttgat 54060 atattattta aacgaagcaa acgccacaga ttgagatacg caaagaacaa tgagaggatc 54120 gactccatta aataa tttat catggagtga taatgtcctg tttccatggc atattacaaa 54180 atcgattccg tccaagatga taaaaacatt taccggcatc ataaacacgg agtttatttt 54240 atatgtctcg cataaacatt actaaaaaaa tatattgttc ggttttcttt cacatcttta 54300 attatgaaaa agtaaatcat tatgagatgg acgcatcgtt cgcgacagta tgtggtacat 54360 acctaacgta tttatggacg acggtaagaa tgaaggtcac gtttctgtca acaatgtcga 54420 cgcgatcgtg taacacgact cacaatagaa tctgtgaatg ctctcccgat catggatgca 54480 aggcatgtgt ttcccaaaca aaatgtggaa taggatacgg agtatccgga gacgtcatct 54540 gttctccgtg tggtctcgga acatattctc acaccgtctc ttccgcagat aaatgcgaac 54600 ccgtacccag aaataccttt aactatatcg atgtggaaat taacctgtat ccagttaacg 54660 acacatcgtg tactcggacg accactaccg gtctcagcga atccatctca acgtcggaac 54720 taactattac tatgaatcat aaagactgcg atcccgtctt cttaataagg tagcgacttc 54780 aggtttcttt acaggagaaa ggtgtgcact ctgaatttcg agattaaatg caataacaaa 54840 gattcttcct ccaaacagtt aacgaaagca aagaatgata ctatcatgcc gcattcggag 54900 acagtaactc tagcgtcgac atctatatac tatatagtaa taccaatact caagactacg 54960 aaactgatac aatctcttat catgtgggta atgtagccat atgcccggta gttgcgatat 55020 acataaactg atcactaatt ccaaacccac ccgcttttta tagtaagttt ttcacccata 55080 aatacaataa ttaatttctc gtaaaagtag aaaatatatt ctaatttatt gcacggtaag 55140 gaagtagaat cataaagaac agtactcaat caatagcaat catgaaacaa tatatcgta c 55200 tggcatgcat gtgcctgcca gtcttcagca atcatcctca tcgtgtacgg aagaagaaaa 55260 caaacatcat atgggaatcg atgttattat caaagtcaca aagcaagacc aaacaccgac 55320 cgatgataag atttgccaat ccgtaacgga aattacagag tccgagtcag atccagatcc 55380 cgaggtggaa tcagtcgagg atgtagatcc tcctaccact tattactcca tcatcggtgg 55440 aggtctgaga atgaactttg gattcaccaa atgtcctcag attaaatcca tctcagaatc 55500 cgctgatgga aagactgtga ggtgtctatc gacatcagat gtagcgaaga agagaaagac 55560 agcgacatca agacccatcc agtactcggg tctaacatct ctcataagaa agtgagttac 55620 gaagatatca tcggttcaac gatcgtcgat acaaaatgtg tcaagaatct agagtttagc 55680 gttcgtatcg gagacatgtg caaggaatca tctgaacttg aggtcaagta tgtcgacgga 55740 tcggcatctg aaggtgcaac cgatgatact tcactcatcg attcaacaaa actcaaagcg 55800 tgtgtctgaa tcgataactc tattcatctg aaattggatg agtagggtta atcgaacgat 55860 tcaggcacac cacgaattaa aaaagtgtac cggacactat attccggttt gcaaaacaaa 55920 aagttacctc tcgcgacttc ttctttttct gtctcaatag tgtgatacga ttatgacact 55980 attcctattt cctttcaggg tatcacaaaa atattaaacc tctttctgat g gtctcatac 56040 aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaatatt tttattctct 56100 ttctctcttt gatggtctca taaaatattt ttattctctt tctctctttg atggtctcat 56160 aaaaaatatt tttattctct ttctctcttt gatggtctca taaaatattt ttattctctt 56220 tctctctttg atggtctcat aaaaaatatt tttattctct ttctctcttt gatggtctca 56280 taaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc tctttctctc 56340 ttcaatggag tcataaaata tttttattct ctttctctct tcgatggtct cacaaaaata 56400 ttaaacctct ttctgatggt gtcactaaaa tatttttatt ctctttctct cttcaatgga 56460 gtcataaaat atttttattc tctttctctc tttgatggtc tcacaaaaat atttttattc 56520 tctttctctc tttgatggtc tcacaaaaat atttttattc tctttctctc tttgatggtc 56580 tcacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 56640 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 56700 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 56760 tctctttctc tctttgatgg tctcataaaa aatattaaac ctctttctga tggtgtcact 56820 aaaatatttt tattctcatt ctctcttcaa tggagtcata aaat attttt attctctttc 56880 tctcttcgat ggtctcacaa aaatattaaa cctctttctg atggtgtcac taaaatattt 56940 ttattctcat tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga 57000 tggtctcaca aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca 57060 ttctctcttc aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat 57120 aaaaaaagtt ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa 57180 tattaaacct ctttctgatg gtgtcactaa aatattttta ttctctttct ctcttcaatg 57240 gagtcataaa atatttttat tctctttctc tcttcgatgg tctcacaaaa atattaaacc 57300 tctttctgat ggtgtcacta aaatattttt attctcattc tctcttcaat ggagtcataa 57360 aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 57420 tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 57480 ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 57540 ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 57600 ttgatggtct cataaaaaat attaaacctc tttctgatgg tgtcactaaa atatttttat 57660 tctcattctc tcttcaatgg agtcataaaa tattttt att ctctttctct cttcgatggt 57720 ctcacaaaaa tattaaacct ctttctgatg gtgtcactaa aatattttta ttctcattct 57780 ctcttcaatg gagtcataaa atatttttat tctctttctc tctttgatgg tctcataaaa 57840 aaagttttac aaaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 57900 ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 57960 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 58020 ttttattctc tttctctctt tgatggtctc acaaaaatat taaacctctt tctgatggag 58080 tcgtaaaaaa gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt 58140 ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt 58200 aaacctcttt ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca 58260 ctaaaatatt ttttattctc tttctgatgc atcaactatt tcttaaacaa taacgtccaa 58320 caacatatac tcgtcgagct tatcaacatc ccctatgccc atctaggtta ccagacaatt 58380 gtatatcata aaataatgtt tataattttt acaaaaatat ttttattctc tttctctctt 58440 tgatggtctc ataaaaaaag ttttacaaaa atatttttat tctctttctc tctttgatgg 58500 tctcataaaa aatattaaac ctctttctga tggtgtcact aaaatatttt tattctcatt 58560 ctctcttcaa tggagtcata aaatattttt attctctttc tctcttcgat ggtctcacaa 58620 aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctcat tctctcttca 58680 atggagtcat aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt 58740 tacaaaaata tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa 58800 aatattttta ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt 58860 tttattctct ttctctcttt gatggtctca taaaaaaagt tttacaaaaa tatttttatt 58920 ctctttctct ctttgatggt ctcataaaaa aagttttaca aaaatatttt tattctcttt 58980 ctctctttga tggtctcata aaaaaagttt tacaaaaata tttttattct ctttctctct 59040 ttgatggtct cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg 59100 gtctcataaa aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctctt 59160 tctctcttca atggagtcat aaaatatttt tattctcttt ctctcttcga tggtctcaca 59220 aaaatattaa acctctttct gatggtgtca ctaaaatatt tttattctca ttctctcttc 59280 aatggagtca taaaatattt ttattctctt tctctctttg atggtctcat aaaaaaagtt 59340 ttacaaaaat atttttattc tc tttctctc tttgatggtc tcataaaaaa agttttacaa 59400 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 59460 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 59520 tctctttctc tctttgatgg tctcataaaa aaagttttac aaaaatattt ttattctctt 59580 tctctctttg atggtctcat aaaaaatatt aaacctcttt ctgatggtgt cactaaaata 59640 tttttattct ctttctctct tcaatggagt cataaaatat ttttattctc tttctctctt 59700 cgatggtctc acaaaaatat taaacctctt tctgatggtg tcactaaaat atttttattc 59760 tctttctctc ttcaatggag tcataaaata tttttattct ctttctctct ttgatggtct 59820 cataaaaaaa gttttacaaa aatattttta ttctctttct ctctttgatg gtctcataaa 59880 aaaagtttta caaaaatatt tttattctct ttctctcttt gatggtctca taaaaaaagt 59940 tttacaaaaa tatttttatt ctctttctct ctttgatggt ctcataaaaa aagttttaca 60000 aaaatatttt tattctcttt ctctctttga tggtctcata aaaaaagttt tacaaaaata 60060 tttttattct ctttctctct ttgatggtct cataaaaaaa gttttacaaa aatattttta 60120 ttctctttct ctctttgatg gtctcataaa aaaagtttta caaaaatatt tttattctct 60180 ttctctcttt gatgg tctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60240 atttttattc tcattttctc tttctctctt caatggagtc ataaaatatt tttattctct 60300 ttctctcttt gatggtctca taaaaaatat taaacctctt tctgatggtg tcactaaaat 60360 atttttattc tcattctctc ttcaatggag tcataaaaaa gttttatctc tttctctctt 60420 cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc 60480 tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatgcat caactatttc 60540 ttaaacaata acgtccaaca acatatactc atcccctatg cccatctagg ttaccagaca 60600 attgtatatc ataaaataat gtttataatt tacacgttaa aatcatataa taaaacgtag 60660 atcgtataat attttttggt atataaatga tctagtaaaa tccatgtagg ggatactgct 60720 cacatttttt ctttggtaca aaatttcaca caagttttta tacagacaaa ttcttgtcca 60780 tatattttaa aacattgact tttgtactaa gaaaaatatc tagactaact atctctttct 60840 ctttctctct tcgatggtct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 60900 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 60960 ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 61020 agttttat ct ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag 61080 tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat taaacctctt 61140 tctgatggtg tcactaaaat atttttattc tctttctctc ttcgatggtc tcacaaaaat 61200 attaaacctc tttctgatgg agtcgtaaaa aagttttatc tctttctcct tcgatggtct 61260 cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 61320 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 61380 ctttctcctt cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa 61440 gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt ctgatggagt 61500 cgtaaaaaag ttttatctct ttctccttcg atggtctcac aaaaatatta aacctctttc 61560 tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac aaaaatatta 61620 aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctctcttcg atggtctcac 61680 aaaaatatta aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctccttcga 61740 tggtctcaca aaaatattaa acctctttct gatagtctct ataaagcgat tgatttttct 61800 taccctctag agtttcctac ggtcgttggt cacacatttt tttctagaca ctaaataaat 61860 agtaagatta aattaattat aaaattatgt atataatatt aattataaaa ttatgtatat 61920 gatttactaa ctttagttag ataaattaat aatacataaa ttttagtata ttaatattat 61980 aaattataataa tacataaatt ttagtatat aatattatat tattagatgt gg cctattaga <210> 16 <211> 66679 <212> DNA <213> Artificial Sequence <220> <223> sVAC fragment 1 <400> 16 tttttttcta gacactaaat aaaatattta aaatataata ttaatgtact aaaacttata 60 tattattaat ttatctaact aaagttagta aattatatat ataattttat aattaattta 120 attttactaa ttttatttag tgtctagaaa aaaatgtgtg acccatgact gtaggaaact 180 ctagagtgta agaaagatcg atcgctttat agagaccatc agaaagaggt ttaatatttt 240 tgtgagacca tcgaagagag aaagagataa aactttttta cgactccatc agaaagaggt 300 ttaatatttt tgtgagacca tcgaagagag aaagagataa aactttttta cgactccatc 360 agaaagaggt ttaatatttt tgtgagacca tcgaaggaga aagagataaa acttttttac 420 gactccatca gaaagaggtt taatattttt gtgagaccat cgaaggagaa agagataaaa 480 cttttttacg actccatcag aaagaggttt aatatttttg tgagaccatc gaagagagaa 540 agagataaaa cttttttacg actccatcag aaagaggttt aatatttttg tgagaccatc 600 gaagagagaa agagataaaa cttttttacg actccatcag aaagaggttt aatatttttg 660 tgagaccatc gaaggagaaa gagataaaac ttttttacga ctccatcaga aagaggttta 720 atatttttgt gagaccatcg aagagagaaa gagataaaac ttttttacga ctccatcaga 780 aagaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac ttttttacga 840 ctccatcaga a agaggttta atatttttgt gagaccatcg aagagagaaa gagataaaac 900 ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg aagagagaaa 960 gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt gagaccatcg 1020 aagagagaaa gagataaaac ttttttacga ctccatcaga aagaggttta atatttttgt 1080 gagaccatcg aagagagaaa gagaaagaga tagttgatct agatattttt cttagtacaa 1140 aagtcaatgt tttaaaatat atggacaaga atttgtctgt ataaaaactt gtgtgaaatt 1200 ttgtaccaaa gaaaaaatgt gagcagtatc ccctacatgg attttactag atcatttata 1260 taccaaaaaa tattatacga tctacgtttt attatatgat tttaacgtgt aaattataaa 1320 cattatttta tgatatacaa ttgtctggta acctagatgg gcatagggga tgttgataag 1380 ctcgacgagt atatgttgtt ggacgttatt gtttaagaaa tagttgatgc atcagaaaga 1440 gaataaaaaa tattttagtg agaccatcga agagagaaag agataaaact tttttacgac 1500 tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact 1560 tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 1620 agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 1680 agagagaaag agataaaac t tttttacgac tccatcagaa agaggtttaa tatttttgtg 1740 agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa 1800 tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa 1860 agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac 1920 tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact 1980 tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 2040 agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 2100 agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg 2160 agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa 2220 tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa 2280 agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac 2340 tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag agataaaact 2400 tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga agagagaaag 2460 agataaaact tttttacgac tccatcagaa agaggtttaa tatttttgtg agaccatcga 2520 agagagaaag agataaaact tttt tacgac tccatcagaa agaggtttaa tatttttgtg 2580 agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa agaggtttaa 2640 tatttttgtg agaccatcga agagagaaag agataaaact tttttacgac tccatcagaa 2700 agaggtttaa tatttttgtg agaccatcga agagagaaag agaataaaaa tattttatga 2760 ctccattgaa gagagaaaga gaaaatgaga atgagaataa aaatatttta gtgacaccat 2820 cagaaagagg tttaatattt ttgtgagacc atcgaagaga gaaagagaat aaaaatattt 2880 tatgactcca ttgaagagag aaagagaaaa tgagaatgag aataaaaata ttttagtgac 2940 accatcagaa agaggtttaa tattttttat gagaccatca aagagagaaa gagaataaaa 3000 atatttttgt aaaacttttt ttatgagacc atcaaagaga gaaagagaat aaaaatattt 3060 ttgtaaaact ttttttatga gaccatcaaa gagagaaaga gaataaaaat atttttgtaa 3120 aacttttttt atgagaccat caaagagaga aagagaataa aaatattttt gtaaaacttt 3180 ttttatgaga ccatcaaaga gagaaagaga ataaaaatat ttttgtaaaa ctttttttat 3240 gagaccatca aagagagaaa gagaataaaa atatttttgt aaaacttttt ttatgagacc 3300 atcaaagaga gaaagagaat aaaaatattt ttgtaaaact ttttttatga gaccatcaaa 3360 gagagaaaga gaataaaaat atttttgtaa aacttttttt atgagaccat cagaaagagg 3420 tttaatattt ttgtgatacc ctgaaaggaa ataggaatag gaataggaat agtgtcataa 3480 tcgtatcaca ctattgagac agaaaaagaa gaagtcgcga gaggtaactt tttgtgaatg 3540 tagttaagaa catttttgtt ttgcaaaccg gaatatagtg tccggtacac ttttttaatt 3600 cgtggtgtgc ctgaatcgtt cgattaaccc tactcatcca atttcagatg aatagagtta 3660 tcgattcaga cacacgcttt gagttttgtt gaatcgatga gtgaagtatc atcggttgca 3720 ccttcagatg ccgatccgtc gacatactta aatccatcct tgacctcaag ttcagatgat 3780 tccttgcaca tgtctccgat acgaacgcta aactctagat tcttgacaca ttttgtatcg 3840 acgatcgttg aaccgatgat atcttcgtaa ctcactttct tatgagagat gttagacccg 3900 agtactggat gggtcttgat gtcgctgtct ttctcttctt cgctacatct gatgtcgata 3960 gacacctcac agtctttgat catagccaga gcttcttcat gagtgatcgc gggagagtcc 4020 ttaccttgtc ctggggacac gctggacaat ctagcattca ctgtgtttcc atcagcggat 4080 tctgagatgg atttaatctg aggacatttg gtgaatccaa agttcattct cagacctcca 4140 ccgatgatgg agtaataagt ggtaggagga tctacatcct cgactgatgt ggaatcatct 4200 tctgattcca cctcgggatc tggatctgac tcgga ctctg taatttccgt tacggattgg 4260 caaatcttat cattggtcgg tgtttggtct tgctttgtga ctttgataat aacatcgatt 4320 cccatatgat gtttgttttc ttcttccgta cacgaggagg aggatgagga tgattgctga 4380 agactggcag gcacatgcat gccaggacga tatattgttt catgattgct attgattgag 4440 tactgttctt tatgattcta cttccttacc gtgcaataaa ttagaatata ttttctactt 4500 ttacgagaaa ttaattattg tatttattat ttatgggtga aaaacttact ataaaaagcg 4560 ggtgggtttg gaattagtga tcagtttatg tatatcgcaa ctaccgggca tatggctatc 4620 gacatcgaga acattaccca catgataaga gattgtatca gtttcgtagt cttgagtatt 4680 ggtattacta tatagtatat agatgtcgac gctagataga cagtctccga atgcggcatg 4740 ataccgtcat cattctttgc tttcgttaac tgtttggagg aaaaattttt gttattgcat 4800 ttaatctcga aattcagagt gcacaccttt ctcctgtaaa gaaacctgaa gttgctacct 4860 tattaaggac ggagaagtat tcctcacgaa atacgggatt acagtcttta tgattcatag 4920 taatagttag ttccgacgtt gagatggatt cgctgagacc ggtagtggtc gttaactgga 4980 tacagattaa tttccacatc gatatagtta aaggtattac tgggtacggg ttcgcattta 5040 tctgcggaag agacggtgtg agaatatgtt ccgagaccac acggagaaca gatgacgtct 5100 ccggatactc cgtatcctat tccacatttt gtttgggaaa cacatgcctt gcatccggat 5160 gatcctttga gaagacaata atatccggga gagcattcac agattctatt gtgagtcgtg 5220 ttacacggtc gcgtcttccg ttacaactta gacaagcggg taaatgatta ttgcgagatg 5280 tgaaggtacc cgaaccacac ggcgtacatt gtgtgttagt cttgctatcg cataatctgg 5340 aagcgtatgt tcccggacac aaattatggc gtttgtattc gttgtcttta cactttccat 5400 cggatggtgc atgcggtgct atatctcttc cgtttattat tatacatgag agaaacaata 5460 tatacgagta taatacggac ttcatgattt aataatgtag taatcgtcgt cttgttcctg 5520 tttcctactt ctccaatcat atagatattt tctttctatc atggataata tttgtaatgg 5580 ttcttttcgt acaacatact gtttagatga tattgcgcat aatttccgga ggcaaatacg 5640 atagtctaga ttgaccgatg gtagactcta atttattgag tgctttgtcg acgagtttac 5700 ttttacgctc catcgataga tggcactgtt ctatgagatc gtcgtacatg ggaaatgaaa 5760 tgtgactgtc tgaatgtatg gctttaagat agctgtgata ccgtatacag gtcggtgtcg 5820 gagattcgaa tctctttaag gcgacttatg tcacgatgat ggaatctatc ttatcgaatg 5880 atatattttt cataaataca cttttatagt cctcgtttaa acagaa ttta ctatgtagtt 5940 ccgcgaatga ctcgtccctt aataggcagt aggctattat cttctttacg tagtaatcgt 6000 cgtagggaga gacatcttgt agaacaacga tttaatcata ggtagagata ctttcagtct 6060 gtggtggatg atgtcattca caacatccgc cttgtatatg atgtttctgt tttcaaacac 6120 caagtcgaat accgtcttta gtcggaaggt tgatgtcgta tccgatgtat gaggcaacat 6180 tgttgttaca attttgaaag gcggtattat agtattcgtc tttctgaatg tcgaacctat 6240 ctagtagata ccgtagtata ttgagagtgt atccttgatt atgttttatg aatagataaa 6300 gtagatgttg tccttcttcc ttttgttcgt gccaattgag taacattatg agaatatgac 6360 ctgttgcaca atcgttccat gatgggtgta caatcaagat tattacgtat cctcgtatcg 6420 gctcctcgag ataaaagagc atacaccaca cgaggactat gtttggtata ctgttgaagg 6480 taagtgtgta accgcgttaa tgtttgctcc ataatctatt atcgcgtaga tgaatcgctt 6540 ctcggctcgc atcttagtgt gacttaactt gtaataattg cttttgtaga acgtggatat 6600 gtgtttacag tagtaatgaa gagaagtgag ttcatcctcg tcggatcctt tgtacagaac 6660 gtaatagttt aagctcccat tgaatttata tctaagataa cacagcaata gatcggatga 6720 tttactaaag tcatcaatgg tgtccgttag tatatcaaag atcttgttat c gattgatag 6780 tggtgtcctt tttcatcctt gctatcaaag ttacgcatgc cgtggtgtaa caatatcttt 6840 aatacagatg gattaaatcg tgtattcatc gtatagcaat gtaatggaga gttacctcgt 6900 ttattcagat cgcagtgttt aataactagc ttaaacagat gagacgatgt atccacatca 6960 aagaacgtga aatacatatg acagacattg ttgacagaaa cgtgaccttc attcttaccg 7020 tcgtccataa atacgttagg tatgtaccac atactgtcgc gaacgatgcg tacaatctcg 7080 tccatctcat aatgatttac tttttcataa ttaaagatgt gaaagaaaaa cagaacaata 7140 tattttttta gtaatgttta tgcgagacat ataaaataaa ctccgtgttt atgatcattt 7200 ttaacagcaa cacattcaat attgtattgt tatttttata ttatttacac aattaacaat 7260 atattattag tttatattac tgaattaata atataaaatt cccaatcttg tcataaacac 7320 acactgagaa acagcataaa cacaaaatcc atcaaaaatg tcgatgaaat atctgatgtt 7380 gttgttcgct gctatgataa tcagatcatt cgccgatagt ggtaacgcta tcgaaacgac 7440 atcgccagaa attacaaacg ctacaacaga tattccagct atcagattat gcggtccaga 7500 gggagatgga tattgtttac acggtgactg tatccacgct agagatattg acggtatgta 7560 ttgtagatgc tctcatggtt atacaggcat tagatgtcag catgtagtat tagtaga cta 7620 tcaacgttca gaaaacccaa acactacaac gtcatatatc ccatctcccg gtattatgct 7680 tgtattagta ggcattatta ttattacgtg ttgtctatta tctgtttata ggttcactcg 7740 acgaactaaa ctacctatac aagatatggt tgtgccataa tttttataaa tttttttatg 7800 agtattttta caaaaaaaat gtataaagtg tatgtcttat gtatatttat aaaaatgcta 7860 agtatgcgat gtatctatgt tatttgtatt tatctaaaca atacctctac ctctagatat 7920 tatacaaaaa ttttttattt cggcatatta aagtaaaatc tagttacctt gaaaatgaat 7980 acagtgggtg gttccgtatc accagtaaga acataatagt cgaatacagt atccgattga 8040 gattttgcat acaatactag tctagaaaga aatttgtaat catcttctgt gacgggagtc 8100 catatatctg tatcatcgtc tagtttatca gtgtcccatg ctatattcct gttatcatca 8160 ttagttaatg aaaataactc tcgtgcttca gaaaagtcaa atattgtatc catacataca 8220 tctccaaaac tatcgcttat acgtttatct ttaacgatac ctatacctag atggttattt 8280 actaacagac attttccaga tctattgact ataactccta tagtttccac atcaaccaag 8340 taatgatcat ctattgttat ataacaataa cataactctt ttccattttt atcagtatgt 8400 atatctatat caacgtcgtc gttgtagtga atagtagtca ttgatctatt atatgaaacg 84 60 gatatgtcta gaacggcaat tgttttacgt ccagttaaca ctttctttga tttaaagtct 8520 agagtctttg caaacataat atccttatcc gactttatat ttcctgtagg gtggtataat 8580 tttattttgc ctccacatat cggtgtttcc aaatatatta ctagacaata ttccatatag 8640 ttattagtta agggtaccca attagaacac gtacgcttat tatcatcatt tggatcgtat 8700 ttcataaaag ttattgtact atcgatgtca acacattcta cattttttaa tcgtctatat 8760 agtatttttc tgatattttc tataatatca gaattgtctt ccatcggaag ttgtatacta 8820 tcggaatcag ttacatgttt aaataattct ctgatgtcat tccttataca atcaaattca 8880 ttattaaaca gtttaatagt ctgtagacct ttatcgtcgt aaatatccat tgtcttatta 8940 gttacgctta tttttatgtg ttttacgttg ctttattata ttttataaga atgattgttt 9000 gacgaatcac gagaactatt aagacacatt attaggtata tattataaaa aagtttttga 9060 ttacgatgtt ataagaggaa agaggacaca ttaacatcat acatcaatta actacattct 9120 tataacatcg taatcaaaag aattgcaatt ttgatgtata acaactgtca atgggttatg 9180 gaattgtata ttacatatta tacggtatgt tggtaacgac aaataccgat cggtaattgt 9240 ctgccggtgt aatagaatta tatatatcta tctattacac cggctgagta tgcataataa 9300 taa gttgtgg tagtatgatc tccatattta taatttagga ctttgtattc agtatttttg 9360 gaatcataaa aaataaaaaa aagttttact aatttaaaat ttaaaaagta tttacatttt 9420 tttcactgtt tagtcgcgga tatggaattc gatcctgcca aaatcaatac atcatctata 9480 gatcatgtaa caatattaca atacatagat gaaccaaatg atataagact aacagtatgc 9540 attatccgaa atattaataa cattacatat tatatcaata tcacaaaaat aaatacacat 9600 ttggctaatc aatttcgggc ttggaaaaaa cgtatcgccg gaagggacta tatgactaac 9660 ttatctagag atacaggaat acaacaatca aaacttactg aaactatacg taactgtcaa 9720 aaaaatagaa acatatatgg tctatatata cactacaatt tagttattaa tgtggttatt 9780 gattggataa ccgatgtgat tgttcaatca atattaagag ggttggtaaa ttggtacata 9840 gctaataata cctatacacc caataataca acaaccattt ctgagttgga tatcatcaaa 9900 atactggata aatacgagga cgtgtataga gtaagtaaag aaaaagaatg tggaatttgc 9960 tatgaagttg tttactcaaa acgatagata ctttggttta ttggattcgt gtactcatat 10020 attttgcata acatgcatca atatatggca taaaacacga agagaaaccg gtgcgtcgga 10080 taattgtcct atatgtcgta cccgttttag aaacataaca atgagcaagt tctataagct 10140 agttaa ctaa taaataaaaa gtttaatttg ttgacgacgt atgtcgttat ttttctcgta 10200 tgaaagatta aattcaattc aattcgttgt ttctaatata atctgccgta ttggatggat 10260 tctcaagaca attgcattta gattatatta tcatgaataa aaatagtagc acgcactact 10320 tcagccaaat attctttttt gaaacgccat ctatcgtagt gaggacacaa gtgaacctat 10380 aattatcaaa tttattagta tcagtcacat gaaggacttt ctgtagagtg acgattctac 10440 catctatggt actaacggtt tcatcctcct tgataccctc acccaaatgt tctataaatt 10500 tagcatcctc gtccgatctc atatcctttg ccaaccaata catgtagcta aaattaggca 10560 taaatttcac acatccagtg caacgaaatt ctccagaaga tgttacgatg tttaggttag 10620 gacatttgat ttcgtcggca ttaacatatg ggtgaacaca cccatacatg aaagcgatga 10680 gaaataggat tctcatcttg ccaaaatatc actagaaaaa atttatttat caattttaaa 10740 ggtataaaaa atacttattg ttgctcgaat attttgtatt tgatggtata cggaagatta 10800 gaaatgtagg tattatcatc aactgattct atggttttat gtattctatc atgtttcact 10860 attgcgtcgg aaataatatc atatgcttcc acatatattt tattttgttt taactcataa 10920 tactcacgta attctggatt attggcatat ctatgaataa ttttagctcc atgatcagta 1098 0 aatattaatg agaacatagt attaccacct accattattt ttttcatttc gttcaattct 11040 tgattgcaaa gatctatata atcattatag cgttgactta tggactctgg aatcttagac 11100 gatgtacagt catctataat catggcatat ttaatacatt gttttatagc atagtagtta 11160 tctacgatgt tagatatttc tctcaatgaa tcaatcacac aatctaatgt aggtttatga 11220 cataatagca ttttcagcag ttcaatgttt ctagattcgt tgatggcaat ggctatacat 11280 gtatatccgt tatttgatct aatgttgaca tctgaaccgg attctagcag taaagatact 11340 agagattgtt tattatatct aacagccttg tgaagaagtg tttctcctcg tttgtcaatc 11400 atgttaatgt ctttaagata aggtaggcaa atgtttatag tactaagaat tgggcaagca 11460 taagacatgt cacaaagacc ctttttgtat gtataagtgt aaaaattata acattcatag 11520 ttggatttac ataggtgtcc aatcgggatc tctccatcat cgagataatt gatggcatct 11580 cccttccttt tttagtagat atttcatcgt gtaagaatca atattaatat ttctaaagta 11640 ttcgtgtata gcctctttat ttaccacagt tccatattcc actagaggga tatcgccgaa 11700 tgtcatatac tcaattagta tatgttggag gacatccgag ttcattgttt tcaatatcaa 11760 aaagatggtt tccttatcat ttctccatag tggtacaata ctacacatta ttccgtg cgg 11820 ctttccattt tccaaaaaca atttgaccaa atctaaatct acatctttat tgtatctata 11880 atcactattt agataatcag ccataattac tcgagtgcaa catgttagat cgtctatata 11940 tgaataagca gtgttatcta ttcctttcat taacaattta acgatgtcta tatctatatg 12000 agatgactta atataatatt gaagagctgt acaatagttt ttatctatag aagacggctt 12060 gattccgtga ttaattagac atttaacaac ttccggacgc acatatgctc tcgtatccga 12120 ctttgaatac agatgagaga tgatatacag atgcaatacg gtaccgcaat ttcgtagttg 12180 ataatcatca tacgcgtatc agtactcgtc ctcataaaga acactgcagc cattttctat 12240 gaacaaatca ataattttag gaacaggatc attgtcatta cataattttc tataactgaa 12300 cgatggtttt cacatttaac actcaagtca aatccatgtt ctaccaacac ctttatcaag 12360 tcaacgtcta catttttgga tttcatatag ctgaatatat taaagtcatt tatgttgcta 12420 aatccagtgg cttctagtag agccatcgct atatccttta actttaacat gtctactatt 12480 tgtgtattct tctaatgggg tagctgtctc caatttttgc gtaatggatt agtgccactg 12540 tctagtagta gtttgacgac ctcgacatta ttacaatgct cattaaaaag gtatgcgtgt 12600 aaagcattat tcttgaattg gttcctggta tcattaggat ctctgtctct caacatctgt 12660 ttaagttcat cgagagccac ctcctcattt tccagatagt caaacatttt gactgaatga 12720 gctactgtga actctataca cccacacaac taatgtcatt aaatattatt tttttgaatg 12780 tatttatacc atgtcaaaaa cttgtacaat tattaataaa aataatttag tgtttaaatt 12840 ttaccagttc cagattttac acctccgtta accccacttt ttacaccact ggacgatcct 12900 cctccccaca ttccaccgcc accagatgta taagttttag atcctttatt actaccatca 12960 tgtccatgga taaagacact ccacatgccg ccactactac cccctttaga agacatatta 13020 ataagactta aggacaagtt taacaataaa attaatcacg agtaccctac taccaaccta 13080 cactattata tgattatagt ttctattttt acagtacctt aactaaagtc tctagtcaca 13140 agagcaatac taccaaccta cactattata tgattatagt ttctattttt ataggaacgc 13200 gtacgagaaa atcaaatgtc taatttctaa cggtagtgtt gataaacgat tatcgtcaat 13260 ggatacctcc tctatcatgt cgtctatttt cttactttgt tctattaact tattagcatt 13320 atatattatt tgattataaa acttatattg cttattagcc caatctgtaa atatcggatt 13380 attaacatat cgtttctttg taggtttatt taacatgtac atcactgtaa gcatgtccgt 13440 accatttatt ttaatttgac gcatatccgc aatttctttt tc gcagtcgg ttataaattc 13500 tatatatgat ggatacatgc tacatgtgta cttataatcg actaatatga agtacttgat 13560 acatattttc agtaacgatt tattattacc acctatgaat aagtacca tactattgt gatcgtcca tactattg tatcttaata tataattctg ctatttctgg gatatattta tctgccagta taacacaaat 13740 agtaatacat gtaaacccat attttgttat tatattaatg tctgcgccat tatctattaa 13800 ccattctact aggctgacac tatgcgactt aatacaatga taaagtatac tacatccatg 13860 tttatctatt ttgtttatat catcaatata cggcttacaa agttttagta tcgataacac 13920 atccaactca cgcatagaga aggtagggaa taatggcata atatttatta ggttatcatc 13980 attgtcatta tctacaacta agtttccatt ttttaaaata tactcgacaa ctttaggatc 14040 tctattgcca aatttttgaa aatatttatt tatatgctta aatctatata atgtagctcc 14100 ttcatcaatc atacatttaa taacattgat gtatactgta tgataagata catattctaa 14160 caatagatct tgtatagaat ctgtatatct tttaagaatt gtggatatta ggatattatt 14220 acgtaaacta ttacacaatt ctaaaatata aaacgtatca cggtcgaata atagttgatc 14280 aactatataa ttatcgattt tgtgattttt cttcctaaac tgtttacgta aatagttaga 14340 tagaatattc attagttcat gaccactata gttactatcg aataacgcgt caaatatttc 14400 ccgtttaata tcgcatttgt caagataata atagagtgtg gtatgttcac gataagtata 14460 ataacgcatc tcttttttgt gtgaaattaa atagtttatc acgtccaaag atgtagcat a 14520 accatcttgt gacctagtaa taatataata atagagaact gttttaccca ttctatcatc 14580 ataatcagtg gtgtagtcgt aatcgtaatc gtctaattca tcatcccaat tataatattc 14640 accagcacgt ctaatctgtt ctattttgat cttgtatcca tactgtatgt tgctacatgt 14700 aggtattcct ttatccaata atagtttaaa cacatctaca ttgggatttg atgttgtagc 14760 gtatttctct acaatattaa taccattttt gatactattt atttctatac ctttcgaaat 14820 tagtaatttc aataagtcta tatcgatgtt atcagaacat agatattcga atatatcaaa 14880 atcattgata tttttatagt cgactgacga caataacaaa atcacaacat cgtttttgat 14940 attattattt ttcttggtaa cgtatgcctt taatggagtt tcaccatcat actcatataa 15000 tggatttgca ccactttcta tcaatgattg tgcactgctg gcatcgatgt taaatgtttt 15060 acaactatca tagagtatct tatcgttaac catgattggt tgttgatgct atcgcatttt 15120 ttggtttctt tcatttcagt tatgtatgga tttagcacgt ttgggaagca tgagctcata 15180 tgatttcagt actgtagtgt cagtactatt agtttcgatc agatcaatgt ctagatctat 15240 agaatcaaaa cacgataggt cagaagataa tgaatatctg tacgcttctt tttgtactgt 15300 aacttctggt tttgttagat ggttgcatcg tgctttaaca tcaatggtac a aattttatc 15360 ctcgctttgt gtatcatatt cgtctctagt ataaaattct atattcagat tatcatgcga 15420 tgtgtatacg ctaacggtat caataaacgg agcacaccat ttagtcataa cagtaatcca 15480 aaatttttta aagtatatct taacgaaaga agttgtgtca ttgtctacgg tgtatggtac 15540 tagatcctca taagtgtata tatctagagt aatgtttaat ttattaaatg gttgataata 15600 tggatcctca tgacaatttc cgaagatgga aatgagatat agacatgcaa taaatctaat 15660 cgaagacatg gttactcctt aaaaaaatac gaataatcac cttggctatt tagtaagtgt 15720 catttaacac tatactcata ttaatccatg gactcataat ctctatacgg gattaacgga 15780 tgttctatat acggggatga gtagttttct tctttaactt tatacttttt actaatcata 15840 tttagactga tgtatgggta atagtgttta aagagttcgt tctcatcatc agaataaatc 15900 aatatctctg tttttttgtt atacagatgt attacagcct catatattac gtaatagaac 15960 gtgtcatcta ccttattaac tttcaccgca tagttgtttg caaatacggt taatcctttg 16020 acctcgtcga tttccgacca atctgggcgt ataatgaatc taaactttaa tttcttgtaa 16080 tcattcgaaa taatttttag tttgcatccg tagttatccc ctttatgtaa ctgtaaattt 16140 ctcaacgcga tatctccatt aataatgatg tcgaattcgt gctg tatacc catactgaat 16200 ggatgaacta acgaatatca acggcgttaa tagtaattta ctttttcatc tttacatatt 16260 gggtactagt tttactatca taagtttata aattccacaa gctactatgg aataagccaa 16320 ccatcttagt ataccacaca tgtcttaaag tttattaatt aattacatgt tgttttatat 16380 atatcgctac gaatttaaag agaaatcagt ttaggaagaa aaaaattatc tatctacatc 16440 atcacgtctc tgtattctac gatagagtgc tactttaaga tgagacatat ccgtgtcatc 16500 aaaaatatac tccattaaaa tgattattcc ggcagcgaac ttgatattgg atatatcaca 16560 acctttgtta atatctacga caatagacag cagtcccatg gttccataaa cagtgagttt 16620 atctttcttt gaagcgatag tttgtagaga tcttataaaa ccgtcaaacg acatcgcatt 16680 tatatcttta gctaattcat atatgttacc atcgtaatat ctaaccgcgt ctatcttaaa 16740 cgtttccatc gctttaaaga cgtttccgat agatggtctc atttcatcag tcatactgag 16800 ccaacaaata taatcgtgta taacatcttt gatagaatca gactctaaag aaaacgaatc 16860 ggctttatta tacgcattca tgataaactt aatgaaaaat gtttttcgtt gtttaagttg 16920 gatgaatagt atgtcttaat aattgttatt atttcattaa ttaatattta gtaacgagta 16980 cactctataa aaacgagaat gacataacta gttatca aag tgtctaggac gcgtaatttt 17040 catatggtat agatcctgta agcattgtct gtattctgga gctattttct ttatcgcatt 17100 agtaagttca gaatatgtta taaatttaaa tcgaataacg aacatgactt tagtaaagtc 17160 gtctatatta actcttttat tttctagcca tcgtaatacc atgtttaaga tagtatattc 17220 tctagttact acgatctcat cgttgtctag aatatcacat actgaatcta catccaattt 17280 tagaaattgg tctgtgttac atatctcttc tatattattg ttgatgtatt gtcgtagaaa 17340 actattacgt agaccatttt ctttataaaa cgaatatata gtactccaat tatctttacc 17400 gatatatttg cacacataat ccattctctc aatcactaca tctttaagat tttcgttgtt 17460 aagatatttg gctaaactat ataattctat tagatcatca acagaatcag tatatatttt 17520 tctagatcca aagacgaact ctttggcgtc ctctataata ttcccagaaa agatattttc 17580 gtgttttagt ttatcgagat ctgatctgtt catatacgcc atgattgtac ggtacgttat 17640 gataaccgca taaaataaaa atccattttc atttttaacc aatactattc ataattgaga 17700 ttgatgtaat actttgttac tttgaacgta aagacagtac acggatccgt atctccaaca 17760 agcacgtagt aatcaaattt ggtgttgtta aacttcgcaa tattcatcaa tttagataga 17820 aacttatact catcatctgt tttaggaatc catgtattat taccactttc caacttatca 17880 ttatcccagg ctatgtttcg tccatcatcg ttgcgcagag tgaataattc ttttgtattc 17940 ggtagttcaa atatatgatc catgcataga tcggcaaagc tattgtagat gtgatttttc 18000 ctaaatctaa tataaaactc gtttactagc aaacactttc ctgatttatc gaccaagaca 18060 catatggttt ctaaatctat caagtggtgg ggatccatag ttatgacgca gtaacataga 18120 ttattacatt cttgactgtc gctaatatct aaatatttat tgttatcgta ttggattctg 18180 catatagatg gcttgtatgt caaagatata gaacacataa ccaatttata gtcgcgcttt 18240 acattctcga atctaaagtt aagagattta gaaaacatta tatcctcgga tgatgttatc 18300 actgtttctg gagtaggata tattaaagtc tttacagatt tcgtccgatt caaataaatc 18360 actaaataat atcccacatt atcatctgtt agagtagtat cattaaatct attatatttt 18420 atgaaagata tatcactgct cacctctata tttcgtacat ttttaaactg tttgtataat 18480 atctctctga tacaatcaga tatatctatt gtgtcggtag acgataccgt tacatttgaa 18540 ttaatggtgt tccattttac aacttttaac aagttgacca attcatttct aatagtatca 18600 aactctccat gattaaatat tttaatagta tccattttat atcactacgg acacaaagta 18660 gctgacataa accattgtat aa tttttatg ttttatgttt attagcgtac acattttgga 18720 agttccggct tccatgtatt tcctggagag caagtagatg atgaggaacc agatagttta 18780 tatccgtact tgcacttaaa gtctacattg tcgttgtatg agtatgatct tttaaacccg 18840 ctagacaagt atccgtttga tattgtagga tgtggacatt taacaatctg acacgtgggt 18900 ggatcggacc attctcctcc tgaacacagg acaccagagt taccaatcaa cgaatatcca 18960 ctattgcaac tataagttac aacgctccca tcggtataaa aatcctcgta tccgttatgt 19020 cttccgttgg atatagatgg aggggattgg catttaacag attcacaaat aggtgcctcg 19080 ggattccata ccatagatcc agtagatcct aattcacaat acgatttaga ttcaccgatc 19140 aaatgatatc cgctattaca agagtacgtt atactagagc caaagtctac tccaccaata 19200 tcaagttggc cattatcgat atctcgaggc gatgggcatc tccgtttaat acattgatta 19260 aagagtgtcc atccagtacc tgtacattta gcatatatag gtcccatttt ttgctttctg 19320 tatccaggta gacatagata ttctatagtg tctcctatgt tgtaattagc attagcatca 19380 gtctccacac tattcttaaa tttcatatta atgggtcgtg acggaatagt acagcatgat 19440 agaacgcatc ctattcccaa caatgtcagg aacgtcacgc tctccacctt catatttatt 19500 tatccgtaaa aatgt tatcc tggacatcgt acaaataata aaaagcccat atatgttcgc 19560 tattgtagaa attgtttttc acagttgctc aaaaacgatg gcagtgactt atgagttacg 19620 ttacactttg gagtctcatc tttagtaaac atatcataat attcgatatt acgagttgac 19680 atatcgaaca aattccaagt atttgatttt ggataatatt cgtattttgc atctgctata 19740 attaagatat aatcaccgca agaacacacg aacatctttc ctacatggtt aaagtacatg 19800 tataattcta tccatttgtc ttccttaact atatatttgt atagataatt acgagtctcg 19860 tgagtaattc cagtaattac atagatgtcg ccgtcgtact ctacagcata aactatacta 19920 tgatgtctag gcatgggaga cttttttatc caacgatttt tagtgaaaca ttccacatcg 19980 tttaatacta catatttttc atacgtggta taaactccac ccattacata tatatcatcg 20040 tttacgaata ccgacgcgcc tgaatatcta ggagtaatta agtttggaag tcttatccat 20100 ttcgaagtgc cgtgtttcaa atattctgcc acacccgttg aaatagaaaa ttctaatcct 20160 cctattacat ataactttcc atcgttaaca caagtactaa cttctgattt taacgacgac 20220 atattagtaa ccgttttcca ttttttcgtt tcaagatcta cccgcgatac ggaataaaca 20280 tgtctattgt taatcatgcc gccaataatg tatagacaat tatgtaaaac atttgcatta 20340 tagaattg tc tatctgtatt accgactatc gtccaatatt ctgttctagg agagtaatgg 20400 gttattgtgg atatataatc agagttttta atgactacta tattatgttt tataccattt 20460 cgtgtcactg gctttgtaga tttggatata gttaatccca acaatgatat agcattgcgc 20520 atagtattag tcataaactt gggatgtaaa atgttgatga tatctacatc gtttggattt 20580 ttatgtatcc actttaataa tatcatagct gtaacatcct catgatttac gttaacgttt 20640 tcgtgggata agatagttgt cagttcatcc tttgataatt ttccaaattc tggatcggat 20700 gtcaccgcag taatattgtt gattatttct gacatcgacg cattatatag ttttttaatt 20760 ccatatcttt tagaaaagtt aaacatcctt atacaatttg tggaattaat attatgaatc 20820 atagttttta cacatagatc tactacaggc ggaacatcaa ttattatggc agcaactagt 20880 atcatttcta cattgtttat ggtgatgttt atcttcttcc agcgtatata gtctaatagc 20940 gattcaaacg cgtgatagtt tataccattc aatataatcg cttcatcctt tagatggtga 21000 tcctgaattc gtttaaaaaa attatacgga gatgccgtaa taatttcctt attcacttgt 21060 ataatttccc cattgataga aaatatcacg ctttccattc ttgaagtact ataagtaatt 21120 atagtataat gtaaaggttt atatattcaa tattttttat aaaaaaatca ttttgacatt 21180 aattcctttt taaatttccg tctatcatct atagaaacgt attctatgaa tttataaaat 21240 gcttttacgt gtcctatcgt aggcgataga accgctaaaa agcctatcga atttctacaa 21300 aagaatctgt tatatggtat agggagagta taaaacatta aatgtccgta cttattaaag 21360 tattcagtag ccaatcctaa ctctttcgaa tacttattaa tggctcttgt tctgtacgaa 21420 tctatttttt tgaacaacgg acctagtggt atatcttgtt ctatgtatct aaaataatgt 21480 ctgactagat ccgttagttt aatatcctca gtcatcttgt ctagaatggc aaatctaact 21540 gcgggtttag gctttagttt agtttttata tctacatcta tgtctttatc taacaccaaa 21600 aatataatag ctaatatttt attacaatca tccggatatt cttctacgat ctcactaact 21660 aatgtttctt tggttatact agtatagtca ctatcggaca aataaagaaa atcagatgat 21720 cgatgaataa tacatttaaa ttcatcatct gtaagatttt tgagatgtct cattaaaata 21780 ttattagggt cagtactcat tatcattcgg cagctattac ttattttatt tttctgtatt 21840 ttattatttt tcaccatata gatcaatcat tagatcatca aaatatgttt caatcatcct 21900 aaagagtatg gtgaatgact cttcccatct aatttctgaa cgttcaccaa tgtctctagc 21960 cactttggca ctaatagcga tcattcgctt agcgtcttct atattattaa ctggttgat t 22020 caatctatct agcaatggac cgtcggacag cgtcattctc atgttcttaa tcaatgtaca 22080 tacatcgccg tcatctacca attcatccaa caacataagc tttttaaaat catcattata 22140 ataggtttga tcgttgtcat ttctccaaag aatatatcta ataagtagag tcctcatgct 22200 tagtaattta actattttag ttaacaacta ttttttatgt taaatcaatt agtacaccgc 22260 tatgtttaat acttattcat attttagttt ttaggattga gaatcaatac aaaaaattaa 22320 tgcatcatta attttagaaa tacttagttt ccacgtagtt aatgaaacat ttgaactcat 22380 cgtacaggac gttctcgtac aggacgtaac tataaaccgg tttatatttg ttcaagatag 22440 atacaaatcc gataactttt tttacgaatt ctacgggatc cactttaaaa gtgtcatacc 22500 gggttctttt tattctttta aacagatcaa tggtgtgatg ttgattaggt cttttacgaa 22560 tttgatatag aatagcgttc acatatcctc cataatggtc aatcgccatt tgttcgtatg 22620 tcataaattc tttaattata tgacactgtg tattatttag ttcatccttg ttcatcatta 22680 ggaatctatc caaaatggca attatactag aactataggt gcgttgtata cacatattga 22740 tgtgtctgtt tatacaatcc atgatatttg gatccatgct actaccttcg ggtaaaattg 22800 tagcatcata taccatttct agtactttag gttcattatt atccattgca g aggacgtca 22860 tgatcgaatc ctaaaaaaat atattatttt tatgttattt tgttaaaaat aatcatcgaa 22920 tacttcgtaa gatactcctt catgaacata atcagttaca aaacgtttat atgaagtaaa 22980 gtatctacga tttttacaaa agtccggatg cataagtaca aagtacgcga taaacggaat 23040 aataatagat ttatctagtc tatctttttc tatagctttc atagttagat acatggtctc 23100 agaagtagga ttatgtaaca tcagcttcga taaaatgact gggttattta gtcttacaca 23160 ttcgctcata catgtatgac cgttaactac aaagtctaca ctaaaatgat tgaacaatag 23220 atagtctacc attgtttcgt attcagatag tacagcgtag tacatagcat cttcacaaat 23280 tatatcattg tctaatagat atttgacgca tcttatggat cccacttcaa cagccatctt 23340 aaaatcggta gaatcatatt gctttccttt atcattaata atttctaaaa catcatctct 23400 atcataaaag atacaaatat taactgtttg atccgtaata acattgctag tcgatagcaa 23460 tttgttaata agatgcgctg ggctcaatgt cttaataaga agtgtaagag gactatctcc 23520 gaatttgttt tgtttattaa catccgttga tggaagtaaa agatctataa tgtctacatt 23580 cttgactgtt ttagagcata caatatggag aggtgtattt ccatcatgat ctggttttga 23640 gggactaatt cctagtttca tcatccatga gattgtagaa gctt ttggat tgtctgacat 23700 aagatgtcta tgaatatgat ttttgccaaa tttatccact atcctggctt cgaatccgat 23760 ggacattatt tttttaaaca ctctttctga aggatctgta cacgccaaca acggaccaca 23820 tccttcttca tcaaccgagt tgttaatctt ggctccatac tgtaccaata aatttattct 23880 ctctatgact tcatcatctg ttcccgagag ataatataga ggtgttttat tatgtttatc 23940 acacgcgttt ggatctgcgc cgtgcgtcag cagcatcgcg actattctat tattattaat 24000 tttagaagct atatgcaatg gataatttcc atcatcatcc gtctcatttg gagagtatcc 24060 tctatgaaga agttcttcga caaatcgttc atctagtcct ttaattccac aatacgcatg 24120 tagaatgtga taattatttc cagaaggttc gatagcttgt agcatattcc taaatacatc 24180 taaattttta ctattatatt tggcataaag agatagataa tactcggccg acataatgtt 24240 gtccattgta gtataaaaat taatatttct atttctattt ctgtatattt gcaacaattt 24300 actctctata acaaatatca taacttagtt cttttatgtc aagaaggcac tggtttagtt 24360 catctataaa tgtcacgcca taactaccac gcatgctata ctcagaatta tgataaagat 24420 atttatcctt ggggtgtagg taatggggat taatctttgt tggatcagtc tctaagttaa 24480 cacatgtcac acatgatcca tttatagtta tatcaca cga tgatgattta tgaattgatt 24540 ccggaagatc gctatcgtat tttgtggttc cacaattcat ttccatacat gttattgtca 24600 cactaatatt atgatgaact ttatctagcc gctgagtggt aaacaacaga acagatagtt 24660 tattatcttt accaacaccc tcagccgctg ccacaaatct ctgatccgta tccatgatgg 24720 tcatgtttat ttctagtccg tatccagtca acactatgtt agcatttctg tcgatatagc 24780 tttcactcat atgacactca ccaataatag tagaattaat gtcgtaattt acaccaatag 24840 tgagttcggc ggcaaagtac caataccggt aatcttgtcg aggaggacat atagtattct 24900 tgtattctac cgaatacccg agagatgcga tacaaaagag taagactaat ttgtaaacca 24960 tcttactcaa aatatgtaac aatagtacga tgcaatgagt aagacaatag gaaatctatc 25020 ttatatacac ataattattc tatcaatttt accaattagt tagtgtaatg ttaacaaaaa 25080 tgtgggagaa tctaattagt ttttctttac acaattgacg tacatgagtc tgagttcctt 25140 gtttttgcta attatttcat ccaatttatt attcttgact atatcgagat cttttgtata 25200 ggagtcagac ttgtattcaa catgcttttc tataatcatt ttagctattt cggcatcatc 25260 caatagtaca ttttccagat tagcagaata gatattaatg tcgtatttga acagagcctg 25320 taacatctca atgtctttat tatctatagc caatttaatg tccggaatga agagaaggga 25380 attattggtg tttgtcgacg tcatatagtc gagcaagaga atcatcatat ccacgtgtcc 25440 attttttata gtgatgtgaa tacaactaag gagaatagcc agatcaaaag tagatggtat 25500 ctctgaaaga aagtaggaaa caatacttac atcattaagc atgacggcat gataaaatga 25560 agttttccat ccagttttcc catagaacat cagtctccaa tttttcttaa caaacagttt 25620 taccgtttgc atgttaccac tatcaaccgc ataatacaat gcggtgtttc ccttgtcatc 25680 aaattgtgaa tcatccagtc cactgaatag caaaatcttt actattttgg tatcttccaa 25740 tgtggctgcc tgatgtaatg gaaattcatt ctctagaaga tttttcaatg ctccagcgtt 25800 caacaacgta catactagac gcacgttatt atcagctatt gcataataca aggcactatg 25860 tccatggaca tccgccttaa atgcatcttt gctagagaga aagcttttca gctgcttaga 25920 cttccaagta ttaattcgtg acagatccat gtctgaaacg agacgctaat tagtgtatat 25980 tttttcattt tttataattt tgtcatattg caccagaatt aataatatct ctaatagatc 26040 tgattagtag atacatggct atcgcaaaac aacatataca catttaataa aaataatatt 26100 tattaagaaa attcagattt cacgtaccca tcaatataaa taaaataatg attccttaca 26160 ccgtacccat attaaggaga tt ccacctta cccataaaca atataaatcc agtaatatca 26220 tgtctgatga tgaacacaaa tggtgtatta aattccagtt tttcaggaga tgatctcgcc 26280 gtagctacca taatagtaga tgcctctgct acagttcctt gttcgtcgac atctatcttt 26340 gcattctgaa acattttata aatatataat gggtccctag tcatatgttt aaacgacgca 26400 ttatctggat taaacatact aggagccatc atttcggcta tcgacttaat atccctctta 26460 ttttcgatag aaaatttagg gagtttaaga ttgtacactt tattccctaa ttgaaacgac 26520 caatagtcta attttgcagc cgtaatagaa tctgtgaaat gggtcatatt atcacctatt 26580 gccaggtaca tactaatatt agcatcctta tacggaaggc gtaccatatc atattcttcg 26640 tcatcgattg tgattgtatt tccttgcaat ttagtaacta cgttcatcat gggaaccgtt 26700 ttcgtaccgt acttattagt aaaactagca ttgcgtgttt tagtgatatc aaacggatat 26760 tgccatatac ctttaaaata tatagtatta atgattgccc atagagtatt attgtcgagc 26820 atattagaat ctactacatt agacataccg gatctacgtt ctactataga attaatttta 26880 ttaaccgcat ctcgtctaaa gtttaatcta tataggccga atctatgata ttgttgataa 26940 tacgacggtt taatgcacac agtattatct acgaaacttt gataagttag atcagtgtac 27000 gtatatttag atgtt ttcag cttagctaat cctgatatta attctgtaaa tgctggaccc 27060 agatctcttt ttctcaaatc catagtcttc aataattcta ttctagtatt acctgatgca 27120 ggcaatagcg acataaacat agaaaacgaa taaccaaacg gtgagaagac aatattatca 27180 tcttgaatat ttttatacgc tactataccg gcattggtaa atccttgcag acgataggta 27240 gacactgaac acgttaacga tagtatcaat aacgcaatca tgattttatg gtattaataa 27300 ttaaccttat ttttatgttc ggtataaaaa ttattgatgt ctacacatcc ttttgtaatt 27360 gacatctata tatccttttg tataatcaac tctaatcact ttaactttta cagttttccc 27420 taccagttta tccctatatt caacatatct atccatatgc atcttaacac tctctgccaa 27480 gatagcttca aagtgaggat agtcaaaaag ataaatatat agagcataat ccttctcgta 27540 tactctgccc tttattacat cacccgcatt gggcaacgaa taacaaaatg caagcatctt 27600 gttaacgggc tcgtaaattg ggataaaaat tatgttttta tatctatttt attcaagaga 27660 atattcagga atttcttttt ccggttgtat ctcatcgcag tatatatcat ttgtacattg 27720 tttcatattt tttaatagtc tacacctttt agtaggacta gtatcgtaca attcatagct 27780 gtattttgaa ttccaatcac gcataaaaat atcttccaat tgttgacgaa gacctaatcc 27840 atcatccggt gtaatattaa tagatgctcc acatgtatcc gtaaagtaat ttcctgtcca 27900 atttgaggta cctatatacg ccgttttatc ggttaccata tatttggcat ggtttaccct 27960 agaatacgga atgggaggat cagcatctgg tacaataaat agctttactt ctatatttat 28020 gtttttagat tttagcatag cgatagatct taaaaagttt ctcatgataa acgaagatc g 28080 ttgccagcaa ctaatcaata gcttaactga cacttgtctg tctatagcgg ctcttcttaa 28140 ttcatcttct atataaggcc aaaacaaaat attgcctgcc ttcgaataaa taatagggat 28200 aaagttcata acagatacat aaacgaattt actcgcattt ctgatacatg acaataaagc 28260 ggttaaatca ttggttcttt ccatagtaca tagttgttgc ggtgcagaag caataaatac 28320 agagtgtgga acgccgctta cgttaatact aagaggatga tctgtattat aatacgacgg 28380 ataaaagttt ttccaattat atggtagatt gttaactcca agataccagt atacctcaaa 28440 aatttgagtg agatccgctg ccaagttcct attattgaag atcgcaatac ccaattcttt 28500 gacctgagtt agtgatctcc aatccatgtt agcgcttcct aaataaatat gtgtattatc 28560 agatatccaa aattttgtat gaagaactcc tcctaggata tttgtaatat ctatgtatcg 28620 tacttcaact ccggccattt gtagtctttc aacatccttt aatggtttgt tagatttatt 28680 gacggctact ctaactcgta ctcctctttt gggtaattgt acaatcttgt ttaatattat 28740 cgtgccgaaa ttcgtaccca cttcatccga taaactccaa taaaaagatg atatatctag 28800 tgtttttgtg gtattggata gaatttccct ccacatgtta aatgtagaca aatatacttt 28860 atcaaattgc atacctatag gaatagtctc tgtaatcact gcgattgtat t atccggatt 28920 cattttattt gttaaaagaa taatcctata tcacttcact ctattaaaaa tccaagtttc 28980 tatttctttc atgactgatt ttttaacttc atccgtttcc ttatgaagat gatgtttggc 29040 accttcataa atttttattt ctctattaca atttgcatgt tgcatgaaat aatatgcacc 29100 taaaacatcg ctaatcttat tgtttgttcc ctggagtatg agagtcgggg ggtgttaatc 29160 ttggaaatta tttttctaac cttgttggta gccttcaaga cctgactagc aaatccagcc 29220 ttaatttttt catgattgat taatgggtcg tattggtatt tataaacttt atccatatct 29280 ctagatactg attctggaca tagctttccg actggcgcat ttagtgtgat ggttcccata 29340 agtttggcag ctagcagatt cagttttgaa acagcatctg cattaactag aggagacatt 29400 agaatcattg ctgtaaacaa gtttggatta tcgtaagagg ctagctccca tggaatgacc 29460 caataagtag atttaatagt taccacgtgc tgtaccaaag tcatcaatca tcattttttc 29520 accattactt cttccatgtc caatatgatc atgtgagaat actaaaattc ctaacgatga 29580 tatgttttca gctagttcgt cataacgtcc agaatgttta ccagctccat gacttatgaa 29640 tactaatgcc ttaggatatg taataggttt ccaatatatg taatcattgt ccagattgaa 29700 catacagttt gcactcatga ttcacgttat ataactatca atat taacag ttcgtttgat 29760 gatcatatta tttttatgtt ttattgataa ttgtaaaaac atacaattaa atcaatatag 29820 aggaaggaga cggctactgt cttttgtgag atagtcatgg cgactaaatt agattatgag 29880 gatgctgttt tttactttgt ggatgatgat aaaatatgta gtcgcgactc catcatcgat 29940 ctaatagatg aatatattac gtggagaaat catgttatag tgtttaacaa agatattacc 30000 agttgtggaa gactgtacaa ggaattgatg aagttcgatg atgtcgctat acggtactat 30060 ggtattgata aaattaatga gattgtcgaa gctatgagcg aaggagacca ctacatcaat 30120 tttacaaaag tccatgatca ggaaagttta ttcgctacca taggaatatg tgctaaaatc 30180 actgaacatt ggggatacaa aaagatttca gaatctagat tccaatcatt gggaaacatt 30240 acagatctga tgaccgacga taatataaac atcttgatac tttttctaga aaaaaaattg 30300 aattgatgat ataggggtct tcataacgca taattattac gttagcattc tatatccgtg 30360 ttaaaaaaaa ttatcctatc atgtatttga gagttttata tgtagcaaac atgatagctg 30420 tgatgccaat aagctttaga tattcacgcg tgctagtgtt agggatggta ttatctggtg 30480 gtgaaatgtc cgttatataa tctacaaaat aatcatcgca tatagtatgc gatagtagag 30540 taaacatttt tatcgtttct actgggttca tacatcg tct acccaattcg gttataaatg 30600 aaattgtcgc caatcttaca cccaacccct tgttatccat tagtatagta ttaacttcgt 30660 tatttatgtc ataaactgta aatgattttg tagatgccat atcatacatg atattcatgt 30720 ccctattata atcattacta actttatcac aatatatgtt gataatatct atatatgatc 30780 tagtctttgt gggcaactgt ctatacaagt cgtctaaacg ttgtttactc atatagtatc 30840 gaacagccat cattacatgg tcccgttccg ttgatagata atcgagtatg ttagtggact 30900 tgtcaaatct atataccata ttttctggaa gtggatatac atagtcgtga tcaacattat 30960 tgctagcctc atcttctata tcctgtacta taccattatc tatatcatct acataatcta 31020 cgatattatt acacataaac atcgacaaca tactattgtt tattatctaa gtcctgttga 31080 tccaaaccct tgatctcctc tatttgtact atctagagat tgtacttctt ccagttctgg 31140 ataatatata cgttgataga ttagctgagc tattctatct ccagtattta cattaaacgt 31200 acattttcca ttattaataa gaatgactcc tatgtttccc ctataatctt cgtctattac 31260 accgcctcct atatcaatgc cttttaggga cagaccagac ctaggagcta ttctaccata 31320 gcagaactta ggcatggaca tactaatatc tgtcttaatt aactgtcgtt ctcctggagg 31380 gatagtataa tcgtaagcgc tatataaatc atatccggcg gcgtaaggtg attgcctagt 31440 aggagattta gctctgttag tttccttaac aaatctaact ggtgagttaa tattcatgtt 31500 gaacataaaa ctaatatttt atttcaaaat tatttaccat cccatatatt ccatgaataa 31560 gtgtgatgat tgtacacttc tatagtatct atatacgatt cacgataaaa tcctcctatc 31620 aatagcagtt tattatccac tatgatcaat tctggattat ccctcggata aataggatca 31680 tctatcagag tccatgtatt gctggattca caataaaatt ccgcatttct accaaccaag 31740 aataaccttc taccgaacac taacgcgcat gatttataat gaggataata agtggatggt 31800 ccaaactgcc actgatcatg attgggtagc aaatattctg tagttgtatc agtttcagaa 31860 tgtcctccca ttacgtatat aacattgttt atggatgcca ctgctggatt acatctaggt 31920 ttcagaagac tcggcatatt aacccaagca gcatccccgt ggaaccaacg ctcaacagat 31980 gtgggatttg gtagacctcc tactacgtat aatttattgt tagcgggtat cccgctagca 32040 tacagtctgg ggctattcat cggaggaatt ggaatccaat tgtttgatat ataatttacc 32100 gctatagcat tgttatgtat ttcattgttc atccatccac cgatgagata tactacttct 32160 ccaacatgag tacttgtaca catatggaat atatctataa tttgatccat gttcatagga 32220 tactctatga atggatactt gt atgatttg cgtggttgtt tatcacaatg aaatattttg 32280 gtacagtcta gtatccattt tacattattt atacctctgg gagaaagata atttgacctg 32340 attacatttt tgataaggag tagcagattt cctaatttat ttcttcgctt tatataccac 32400 ttaatgacaa aatcaactac ataatcctca tctggaacat ttagttcatc gctttctaga 32460 ataagtttca tagatagata atcaaaattg tctatgatgt catcttccag ttccaaaaag 32520 tgtttggcaa taaagttttt agtatgacat aagagattgg atagtccgta ttctataccc 32580 atcatgtaac actcgacaca atattccttt ctaaaatctc gtaagataaa gtttatacaa 32640 gtgtagatga taaattctac agaggttaat atagaagcac gtaataaatt gacgacgtta 32700 tgactatcta tatatacctt tccagtatac gagtaaataa ctatagaagt taaactgtga 32760 atgtcaaggt ctagacaaac ccttgtaact ggatctttat ttttcgtgta tttttgacgt 32820 aaatgtgtgc gaaagtaagg agataacttt ttcaatatcg tagaattgac tattatattg 32880 ccacctatag catcaataat tgttttgaat ttcttagtca tagacaatgc taatatattc 32940 ttacagtaca cagtattaac aaatatcggc atttatgttt ctttaaaagt caacatctaa 33000 agaaaaatga ttatcttctt gagacataac tcccattttt tggtattcac ccacacgttt 33060 ttcgaaaaaa ttagt ttttc cttccaatga tatattttcc atgaaatcaa acggattggt 33120 aacattataa atttttttaa atcccaattc agaaatcaat ctatccgcga cgaattctat 33180 atatgttttc atcatttcac aattcattcc tataagttta actggaagag ccgcagtaag 33240 aaattcttgt tcaatggata ccgcatctgt tataatagat ctaacggttt cttcactcgg 33300 tggatgcaat aaatgtttaa acatcaaaca tgcgaaatcg cagtgcagac cctcgtctct 33360 actaattagt tcgttggaaa acgtgagtcc gggcattagg ccacgctttt taagccaaaa 33420 tatggaagcg aatgatccag aaaagaagat tccttctact gcagcaaagg caataagtct 33480 ctctccataa ccggcgctgt catgtatcca cttttgagcc caatcggcct tcttttttac 33540 acaaggcatc gtttctatgg cattaaagag atagtttttt tcattactat ctttaacata 33600 agtatcgatc aaaagactat acatttccga atgaatgttt tcaatggcca tctgaaatcc 33660 gtagaaacat ctagcctcgg taatctgtac ttctgtacaa aatcgttccg ccaaattttc 33720 attcactatt ccgtcactgg ctgcaaaaaa cgccaataca tgttttataa aatatttttc 33780 gtctggtgtt agtttattcc aatcattgat atctttagat atatctactt cttccactgt 33840 ccaaaatgat gcctctgcct ttttatacat gttccagatg tcataatatt ggattgggaa 33900 aataacaa at ctatttggat ttggtgcaag gatgggttcc ataactaaat taacaataac 33960 aataaatttt ttttcagtta tctatatgcc tgtacttgga tcttttgtac atcgatatcg 34020 ccgcaatcac tacaataatt acaagtatta ttgatagcat tgttattagt actatcataa 34080 ttaaattatc gacattcatg ggtgctgaat aatcgttatt atcatcatta tcattttgta 34140 attgtgacat catactagat aaatcgtttg cgagattgtt gtgggaagcg ggcatggagg 34200 atgaattatc gttattatta tttaacgcct cccattcgga ttcacaaatg ttacgcacat 34260 tcaacatttt atggaaacta taattttgtg aaaacagata acaagaaaac tcgtcatcgt 34320 tcaaattttt aacgatagta aaccgattaa acgtcgagct aatttctaac gctagcgact 34380 ctgttggata tgggtttcca gatatatatc ttttcagttc ccctacgtat ctataatcat 34440 ctgtaggaaa tggaagatat ttccatttat ctactgttcc taatatcata tgtggtggtg 34500 tagtagaacc attaagcgcg aaagatgtta tttcgcatcg tattttaact tcgcaataat 34560 ttctggttag ataacgcact ctaccagtca agtcaatgat attagccttt acagatatat 34620 tcatagtagt tgtaacgatg actccatctt ttagatgcga tactcctttg tatgtaccag 34680 aatcttcgta ccgcaaactc gatatattta aacaagttaa tgagatatta acgcgtttta 34740 tgaatgatga tatataacca gaagttttat cctcggtggc tagcgctata accttatcat 34800 tataatacca actagtgtga ttaatatgtg acacgttagt gtgggtacaa atatgtacat 34860 tatcgtctac gtcgtattcg atacatccgc atacagccaa caaatataaa atgacaaata 34920 ctctaacgcc gttcgtaccc atcttgatgc ggtttaataa atgttttgat ttcaatttat 34980 tgtaaaaaaa gattcggttt tatactgttc gatattctca ttgcttatat tttcatctat 35040 catctccaca cagtcaaatc cgtggttagc atgcacctca tcaaccggta aaagactatc 35100 ggactcttct atcattataa ctctagaata tttaatttgg tcattattaa tcaagtcaat 35160 tatcttattt ttaacaaacg tgagtatttt actcattttt tataaaaact tttagaaata 35220 tacagactct atcgtgtgtc tatatcttct ttttatatcc aatgtattta tgtctgattt 35280 ttcttcattt atcatatata atggtccaaa ttctacacgt gcttcggatt catccagatc 35340 attaaggttc ttataattgt aacatccttc tcttccctct tctacatctt ccttcttatt 35400 cttattctta gcgtcacaga atctaccaca gcaggatccc atgacgagcg tcatattaaa 35460 ctaatccatt ttcaattata atatacgatt agtaatgacc attaaaataa aaaatattct 35520 tcataaccgg caagaaagtg aaaagttcac attgaaacta tgtcagtagt atacatcat g 35580 aaatgatgat atatatatac tctattttgg tggaggatta tatgatataa ttcgtggata 35640 atcattctta agacacattt cttcattcgt aaatcttttc acgttaaatg agtgtccata 35700 ttttgcaatt tcttcatatg atggcggtgt acgtggacga agctgctcct gttcttgttg 35760 tagtcgccga ctgtcgtgtt tgcgtttaga tccctccatt atcgcgattg cgtagatgga 35820 gtactattat ataccttgta attaaatttt tttattaatt aaacgtataa aaacgttccg 35880 tatctgtatt taagagccag atttcgtcta atagaacaaa tagctacagt aaaaataact 35940 agaataattg ctacacccac tagaaaccac ggatcgtaat acggcaatcg gttttcgata 36000 ataggtggaa cgtatatttt atttaaggac ttaacaattg tctgtaaacc acaatttgct 36060 tccgcggatc ctgtattaac tatctgtaaa agcatatgtt gaccgggcgg agccgaacat 36120 tctccgatat ctaatttctg tatatctata atattattaa cctccgcata cgcattacag 36180 ttcttttcta gcttggatac cgcactaggt acatcgtcta gatctattcc tatttcttca 36240 gcgatagctc ttctatcctt ttccggaagc aatgaaatca cttcaataaa tgattcaacc 36300 atgagtgtga aactaagtcg agaattactc atgcatttgt tagttattcg gagcgcgcaa 36360 tttttaaact gtcctataac ctctcctata tgaatagcac aagtgacatt a gtagggata 36420 gaatgttgag ctaatttttg taaataacta tctataaaaa gattatacaa agttttaaac 36480 tctttagttt ccgccattta tccagtctga gaaaatgtct ctcataataa atttttccaa 36540 gaaactaatt gggtgaagaa tggaaacctt taatctatat ttatcacagt ctgttttggt 36600 acacatgatg aattcttcta atgctgtact aaattcgata tctttttcga tttctggata 36660 tgtttttaat aaagtatgaa caaagaaatg gaaatcgtaa taccagttat gttcaacttt 36720 gaaattgttt tttattttct tgttaatgat tccagccact tgggaaaagt caaagtcgtt 36780 taatgccgat ttaatacgtt cattaaaaac aaacttttta tcctttagat gaattattat 36840 tggttcattg gaatcaaaaa gtaagatatt atcgggttta agatctgcgt gtaaaaagtt 36900 gtcgcaacag ggtagttcgt agattttaat gtataacaga gccatctgta aaaagataaa 36960 ctttatgtat tgtaccaaag atttaaatcc taatttgata gctaactcgg tatctacttt 37020 atctgccgaa tacagtgcta ggggaaaaat tataatattt cctctttcgt attcgtagtt 37080 agttctcttt tcatgttcga aaaagtgaaa catgcggtta aaatagttta taacattaat 37140 attactgtta ataactgccg gataaaagtg ggatagtaat ttcacgaatt tgatactgtc 37200 ctttctctcg ttaaacgcct ttaaaaaaac tttagaagaa tatc tcaatg agagttcctg 37260 accatccata gtttgtatca ataatagcaa catatgaaga acccgtttat acagagtatg 37320 taaaaatgtt aatttatagt ttaatcccat ggcccacgca cacacgatta attttttttc 37380 atctcccttt agattgttgt atagaaattt gggtactgtg aactccgccg tagtttccat 37440 gggactatat aattttgtgg cctcgaatac aaattttact acatagttat ctatcttaaa 37500 gactatacca tatcctcctg tagatatgtg ataaaaatcg tcgtttatag gataaaatcg 37560 tttatccttt tgttggaaaa aggatgaatt aatgtaatca ttctcttcta tctttagtag 37620 tgtttcctta ttaaaattct taaaataatt taacaatcta actgacggag cccaattttg 37680 gtgtaaatct aattgggaca ttatgttgtt aaaatacaaa cagtctccta atataacagt 37740 atctgataat ctatggggag acatccattg atattcaggg gatgaatcat tggcaacacc 37800 catttattgt acaaaaagcc ccaatttaca aacgaaagtc caggtttgat agagacaaac 37860 aattaactat tttgtctctg tttttaattt ctttggtaat gaaattattc acaatatcag 37920 tatcttcttt atctaccaga gattttacta acttgataac cttggctgtc tcattcaata 37980 gggtagtaat atttgtatgt gtgatattga tatctttttg aattgtttct tttagaagtg 38040 attctttgat ggtgccagca tacgaattac aataatg cag aaactcagtt aacatgcagg 38100 aattatagta agccaattcc aattgttgcc tgtattgtat tagagtatta atatgcgcaa 38160 tggtgtcctt gcgtttctct gatagaatgc gagcagcgat tttggcgtta tcatttgacg 38220 atatttctgg aatgacgaat cctgtttcta ctaacttttt ggtaggacaa agtgaaacaa 38280 tcaagaagat agcttctcct cctatttgtg gaagaaattg aactcctcta gatgatctac 38340 tgacgatagt atctccttga cagatattgg accgaattac agaagtacct ggaatgtaaa 38400 gccctgaaac cccctcattt tttaagcaga ttgttgccgt aaatcctgca ctgtgaccaa 38460 gatagagagc tcctttggtg aatccatctc tatgtttcag tttaaccaag aaacagtcag 38520 ctggtctaaa atttccatct ctatctaata cagcatctaa cttgatgtca ggaactatga 38580 ccggtttaat gttatatgta acattgagta aatccttaag ttcataatca tcactgtcat 38640 cagttatgta cgatccaaac aatgtttcta ctggcatagt ggatacgaag atgctatcca 38700 tcagaatgtt tccctgatta gtattttcta tatagctatt cttctttaaa cgattttcca 38760 aatcagtaac tatgttcatt tttttaggag taggacgcct agccagtatg gaagaggatt 38820 ttctagatcc tctcttcaac atctttgatc tcgatggaat gcaaaacccc atagtgaaac 38880 aaccaacgat aaaaataata ttgtttttca ctttttataa ttttaccatc tgactcatgg 38940 attcattaat atctttataa gagctactaa cgtataattc tttataactg aactgagata 39000 tatacaccgg atctatggtt tccataattg agtaaatgaa tgctcggcaa taactaatgg 39060 caaatgtata gaacaacgaa attatactag agttgttaaa gttaatattt tctatgagct 39120 gttccaataa attatttgtt gtaactgcgt tcaagtcata aatcatcttg atactatcca 39180 gtaaaccgtg tttaagttct ggaatattat catcccattg taaagcccct aattcgacta 39240 tcgaatatcc tgctctgata gcagtttcaa tatcgacgga cgtcaatact gtaataaagg 39300 tggtagtatt gtcatcatcg tgataaacta cgggaatatg gtcgttagta ggtacggtga 39360 ctttacacaa cgcgatatat aactttcctt ttgtaccatt tttaacgtag ttgggacgtc 39420 ctgcagggta ttgttttgaa gaaatgatat cgagaacaga tttgatacga tatttgttgg 39480 attcctgatt attcactata atataatcta gacagataga tgattcgata aatagagaag 39540 gtatatcgtt ggtaggataa tacatcccca ttccagtatt ctcggatact ctattgatga 39600 cactagttaa gaacatgtct tctattctag aaaacgaaaa catcctacat ggactcatta 39660 aaacttctaa cgctcctgat tgtgtctcga atgcctcgta caaggatttc aaggatgcca 39720 tagattcttt gaccaacgat tt agaattgc gtttagcatc tgattttttt attaaatcga 39780 atggtcggct ctctggtttg ctaccccaat gataacaata gtcttgtaaa gataaaccgc 39840 aagaaaattt atacgcatcc atccaaataa ccctagcacc atcggatgat attaatgtat 39900 tattatagat tttccatcca caattattgg gccagtatac tgttagcaac ggtatatcga 39960 atagattact catgtaacct actagaatga tagttcgtgt actagtcata atatctttaa 40020 tccaatctaa gaaatttaaa attagatttt ttacactgtt aaagttaaca aaggtattac 40080 ccggatacgt ggatatcata tatggcattg gtccattatc agtaatagct ccataaactg 40140 atacggcgat ggtttttata tgtgtttgat ctaacgagga agaaattcgc gcccacaatt 40200 catctctaga tatgtattta atatcaaacg gtaacacatc aatttcggga cgcgtatatg 40260 tttctaaatt tttaatccaa atataatgat gacctatatg ccctattatc atactgtcaa 40320 ctatagtaca cctagagaac ttacgataca tctgtttcct ataatcgtta aattttacaa 40380 atctataaca tgctaaacct tttgacgaca gccattcatt aatttctgat atggaatctg 40440 tattctcgat accgtattgt tctaaagcca gtgctatatc tccctgttcg tgggaacgct 40500 ttcgtataat atcgatcaac ggataatctg aagtttttgg agaataatat gactcatgat 40560 ctatttcgtc cataa acaat ctagacatag gaattggagg cgatgatctt aattttgtgc 40620 aatgagtcgt caatcctata acttctaatc ttgtaatatt catcatcgac ataatactat 40680 ctatgttatc atcataatatatt 40 tagatacct gtttaggcct t acacttc gtttatt t t acattc gtttagtt t t acattc gtttatt t t t t t t ctc t ataatatt agatttgtac cctgtttaac atgatggcgt tctatacgtc tctattttct tttttttaaa 40860 tttttaacga tttactgtgg ctagataccc aatctctctc aaatattttt ttagcctcgc 40920 ttacaagctg tttatctata ctattaaaac tgacgaatcc gtgattttgg taatgggttc 40980 cgtcgaaatt tgccgaagtg atatgaacat attcgtcgtc gactatcaac aattttgtat 41040 tattctgaat agtgaaaacc ttcacagata gatcattttg aacacacaac gcgtctagac 41100 ttctggcggt tgccatagaa tatacgtcgt tcttatccca attaccaact agaagtctga 41160 tcttaactcc tctattaatg gctgcttcta taatggagtt gtaaatgtcg ggccaatagt 41220 agctattacc gtcgacacgt gtagtgggaa ctatggccaa atgttcaata tctatactag 41280 tcttagccga cttgagttta tcaataacta catcggtatc tagatctcta gaatatccca 41340 ataggtgttc cggagaatca gtaaagaaca ctccacctat aggattctta atatgatacg 41400 cagtgctaac tggcaaacaa caagccgcag agcataaatt caaccatgaa ttttttgcgc 41460 tattaaaggc tttaaaagta tcaaatcttc tacgaagatc tgtggccagc gggggataat 41520 cagaatatac acctaacgtt ttaatcgtat gtatagatcc tccagtaaat gacgcgtttc 41580 ctacataaca tctttcatca tctgacaccc aaaaacaacc gagtagtagt cccacatta t 41640 tttttttatc tatattaacg gttataaaat ttatatccgg gcagtgactt tgtagctctc 41700 ccagatttct tttccctcgt tcatctagca aaactattat tttaatccct ttttcagatg 41760 cctcttttag tttatcaaaa ataagcgctc ccctagtcgt actcagagga ttacaacaaa 41820 aagatgctat gtatatatat ttcttagcta gagtgataat ttcgttaaaa cattcaaatg 41880 ttgttaaatg atcggatcta aaatccatat tttctggtag tgtttctacc agcctacatt 41940 ttgctcccgc aggtaccgat gcaaatggcc acatttagtt aacataaaaa cttatacatc 42000 ctgttctatc aacgattcta gaatatcatc ggctatatcg ctaaaatttt catcaaagtc 42060 gacatcacaa cctaactcag tcaatatatt aagaagttcc atgatgtcat cttcgtctat 42120 ttctatatcc gtatccattg tagattgttg accgattatc gagtttaaat cattactaat 42180 actcaatcct tcagaataca atctgtgttt cattgtaaat ttataggcgg tgtatttaag 42240 ttggtagatt ttcaattatg tatcaatata gcaacagtag ttcttgctcc tccttgattc 42300 tagcatcctc ttcattattt tcttctacgt acataagcat gtccaatacg ttagacaaca 42360 caccgacgat ggcggccgcc acagacacga atatgactag accgatgacc atttaaaaac 42420 ccctctctag ctttcactta aactgtatcg attattcttt tagaacatgt a taatataaa 42480 aacattattc tatttcgaat ttaggcttcc aaaaattttt catccgtaaa ccgataataa 42540 tatatataga cttgttaata gtcggaataa atagattaat gcttaaacta tcatcatctc 42600 cacgattaga gatacaatat ttacattttt tttgctgttt cgaaacttta tcaatacacg 42660 ttaatacaaa cccaggaagg agatattgaa actgaggctg ttgaaaatga aacggtgaat 42720 acaataattc agataatgta aaatcatgat tccgtattct gatgatatta gaactgctaa 42780 tggatgtcga tggtatgtat ctaggagtat ctattttaac aaagcatcga tttgctaata 42840 tacaattatc cttttgatta attgttattt tattcatatt cttaaaaggt ttcatattta 42900 tcaattcttc tacattaaaa atttccattt ttaatttatg tagcccccgc aatactcctc 42960 attacgtttc attttttgtc tataatatcc attttgttca tctcggtaca tagattatcc 43020 aattgagaag cgcatttagt agttttgtac attttaagtt tattgacgaa tcgtcgaaaa 43080 ctagttatag ttaacatttt attatttgat accctgatat taatacccct gccgttacta 43140 ttatttataa ctgatgtaat ccacgtaaca ttagaattaa ttatcgatag taatgcatcg 43200 acgcttccaa aattgtctat tataaactca ccgataattt ttttattgca tgttttcata 43260 ttcattagga ttatcaaatc tttaatctta ctacgattgt atgc gttgat attgcaagac 43320 gtcattctaa aagacggagg atctccatca aatgccagac aatcacgtac aaagtacatg 43380 gaaataggtt ttgttctatt gcgcatcata gatttatata gaacacccgt agaaatacta 43440 atttgtttta ctctataaaa tactaatgca tctatttcat cgttttgtat aacgtctttc 43500 caagtgtcaa attccaaatt tttttcattg atagtaccaa attcttctat ctctttaact 43560 acttgcatag ataggtaatt acagtgatgc ctacatgccg ttttttgaaa ctgaatagat 43620 gcgtctagaa gcgatgctac gctagtcaca atcaccactt tcatatttag aatatatgta 43680 tgtaaaaata tagtagaatt tcattttgtt tttttctatg ctataaatga attctcattt 43740 tgcatctgct catactccgt tttatatcaa taccaaagaa ggaagatatc tggttctaaa 43800 agccgttaaa gtatgcgatg ttagaactgt agaatgcgaa ggaagtaaag cttcctgcgt 43860 actcaaagta gataaaccct catcgcccgc gtgtgagaga agaccttcgt ccccgtccag 43920 atgcgagaga atgaataacc ctggaaaaca agttccgttt atgaggacgg acatgctaca 43980 aaatatgttc gcggctaatc gcgacaacgt ggcgtcgaga cttttgaact aaaatacaat 44040 tatatccttt tcgatattaa taaatccgtg tcgtccaggt tttttatctc tttcagtatg 44100 tgaatagata ggtattttat ctctattcat catcgaa ttt aagagatccg ataaacattg 44160 tttgtattct ccagatgtca gcatctgata caacaatata tgtgcacata aacctctggc 44220 acttatttca tgtaccttcc ccttatcact aaggagaata gtatttgaga aatatgtata 44280 catgatatta tcatgaatta gatatacaga atttgtaaca ctctcgaaat cacacgatgt 44340 gtcggcgtta agatctaata tatcactcga taacacattt tcatctagat acactagaca 44400 ttttttaaag ctaaaatagt ctttagtagt gacagtaact atgcgattat tttcatcgat 44460 gatacatttc atcggcatat tattacgctt accatcaaag actataccat gtgtatatct 44520 aacgtattct agcatggttg ccatacgcgc attaaacttt tcaggatctt tggatagatc 44580 ttccaatcta tctatttgag aaaacatttt tatcatgttc aatagttgaa acgtcggatc 44640 cactatatag atattatcta taaagatttt aggaactacg ttcatggtat cctggcgaat 44700 attaaaacta tcaatgatat gattatcgtt ttcatctttt atcaccatat agtttctaag 44760 atatgggatt ttacttaata taatattatt tcccgtgata aattttatta gaaaggccaa 44820 atctataaga aaagttctag aattagtctg aagaatatct atatcgccgt accgtatatt 44880 tggattaatt agatatagag aatatgatcc gtaacatata caacttttat tatggcgtct 44940 aagatattct tccatcaact tattaacatt tttgactagg gaagatacat tatgacgtcc 45000 cattactttt gccttgtcta ttactgcgac gttcatagaa tttagcatat ctcttgccaa 45060 ttcttccatt gatgttacat tataagaaat tttagatgaa attacatttg gagctttaat 45120 agtaagaact cctaatatgt ccgtgtatgt ggtcactaat acagattgta gttctataat 45180 cgtaaataat ttacctatat tatatgtttg agtctgttta gaaaagtagc taagtatacg 45240 atcttttatt tctgatgcag atgtattaac atcggaaaaa aatctttttt tattcttttt 45300 tactaaagat acaaatatgt ctttgttaaa aacagttatt ttttgaatat ttctagcttg 45360 taattttaac atatgatatt cgttcacact aggtactctg cctaaatagg tttctataat 45420 ctttaatgta atattaggaa gagtattctg atcaggattc ctattcattt tgaggattta 45480 aaactctgat tattgtctaa tatggtctct acgcaaactt tttcacagag cgatagagtt 45540 tttgataact cgtttttctt aagaaatata aaactactgt ctccagagct cgctctatct 45600 tttattttat ttaattcgat acaaactcct gatactggtt cagaaagtaa ttcattaatt 45660 ttcagtcctt tatagaagat atttaatata gataatacaa aattttcagt tcttgatatc 45720 gatctgattg atcctagaac tagatatatt aataacgtgc tcattaggca gtttatggca 45780 gcttgataat tagatatagt at attccagt tcatatttat tagataccgc attgcccaga 45840 ttttgatatt ctatgaattc ctctgaaaat aaatccaaaa taactaaaca ttctattttt 45900 tgtggattag tgtactctct tccctctatc atgttcacta ctggtgtcca cgatgataaa 45960 tatctagagg gaatataata tagtccatag gatgccaatc tagcaatgtc gaataactgt 46020 aatttgattc ttcgttcttc attatgaatt gattcttgag gtataaacct aacacaaatt 46080 atattattag acttttcgta tgtaatgtct ttcatgttat aagtttttaa tcctggaata 46140 gaatctattt taatgaggct tttaaacgca gagttctcca acgagtcaaa gcataatact 46200 ctgttgtttt tcttatatac gatgttacga ttttcttctt tgaatggaat aggtttttga 46260 attagtttat aattacaaca taatagataa ggaagtgtgc aaatagtacg cggaaaaaac 46320 ataatagctc ccctgttttc atccatggtt ttaagtaaat gatcactggc ttctttagtc 46380 aatggatatt cgaacattaa ccgtttcatc atcattggac agaatccata tttcttaatg 46440 taaagagtga tcaaatcatt gtgtttattg taccatcttg ttgtaaatgt gtattcggtt 46500 atcggatctg ctcctttttc tattaaagta tcgatgtcga tctcgtctaa gaattcaact 46560 atatcgacat atttcatttg tatacacata accattacta acgtagaatg tataggaaga 46620 gatgtaacgg gaaca gggtt tgttgattcg caaactattc taatacataa ttcttctgtt 46680 aatacgtctt gcacgtaatc tattatagat gccaagatat ctatataatt attttgtaag 46740 atgatgttaa ctatgtgatc tatataagta gtgtaataat tcatgtattt cgatatatgt 46800 tccaactctg tctttgtgat gtctagtttc gtaatatcta tagcatcctc aaaaaatata 46860 ttcgcatata ttcccaagtc ttcagttcta tcttctaaaa aatcttcaac gtatggaata 46920 taataatcta ttttacctct tctgatatca ttaatgatat agtttttgac actatcttct 46980 gtcaattgat tcttattcac tatatctaag aaacggatag cgtccctagg acgaactact 47040 gccattaata tctctattat agcttctgga cataattcat ctattatacc agaattaatg 47100 ggaactattc cgtatctatc taacatagtt ttaagaaagt cagaatctaa gacctgatgt 47160 tcatatattg gttcatacat gaaatgatct ctattgatga tagtgactat ttcattctct 47220 gaaaattggt aactcattct atatatgctt tccttgttga tgaaggatag aatatactca 47280 atagaatttg taccaacaaa ctgttctctt atgaatcgta tatcatcatc tgaaataatc 47340 atgtaaggca tacatttaac aattagagac ttgtctcctg ttatcaatat actattcttg 47400 tgataattta tgtgtgaggc aaatttgtcc acgttcttta attttgttat agtagatatc 47460 aaatccaa tg gagctacagt tcttggctta aacagatata gtttttctgg aacgaattct 47520 acaacattat tataaaggac tttgggtaga taagtgggat gaaatcctat tttaattaat 47580 gcgatagcct tgtcctcgtg cagatatcca aacgcttttg tgatagtatg gcattcattg 47640 tctagaaacg ctctacgaat atctgtgaca gatatcatct ttagagaata tactagtcgc 47700 gttaatagta ctacaatttg tattttttaa tctatctcaa taaaaaaatt aatatgtatg 47760 attcaatgta taactaaact actaactgtt attgataact agaatcagaa tctaatgatg 47820 acgtaaccaa gaagtttatc tactgccaat ttagctgcat tatttttagc atctcgttta 47880 gattttccat ctgccttatc gaatactctt ccgtcgatgt ctacacaggc ataaaatgta 47940 ggagagttac taggccccac tgattcaata cgaaaagacc aatctctcct agtaatttgg 48000 cagtactcat taataacggt gacagggtta gcacctttcc aatcaataat ttttttagcc 48060 ggaataacat catcaaaaga cttatgatcc tctctcattg atttttcgcg ggatacatca 48120 tctattatga cgtcagccat agcatcagca tccggcttat ccgcctccgt tgtcataaac 48180 caacgaggag gaatatcgtc ggagctgtac accatagcac tacgttgaag atcgtacaga 48240 gctttattaa cttctcgctt ctccatatta agttgtctag ttagttgtgc agcagtagct 48300 ccttcgattc caatggtttt aatagcctca cacacaatct ctgcgttaga acgctcgtcg 48360 atatagattt tagacatttt tagagagaac taacgcaatc agtaataaaa ctaatttatt 48420 ttatcatttt ttttattcat catcctctgg tggttcgtcg tttctatcga atgtagctct 48480 gattaacccg tcatctatag gtgatgctgg ttctggagat tctggaggag atggattatt 48540 atctggaaga atctctgtta tttccttgtt ttcatgtatc gattgcgttg taacattaag 48600 attgcgaaat gctctaaatt tgggaggctt aaagtgttgt ttgcaatctc tacacgcgtg 48660 tctaactagt ggaggttcgt cagcggctct agtttgaatc atcatcggcg tagtattcct 48720 acttttacag ttaggacacg gtgtattgta tttctcgtcg agaacgttaa aataatcgtt 48780 gtaactcaca tcctttattt tatctatatt gtattctact cctttcttaa tgcattttat 48840 accgaataag agatagcgaa ggaattcttt ttcggtgccg ctagtaccct taatcatatc 48900 acatagtgtt ttatattcca aatttgtggc aatagacggt ttatttctat acgatagttt 48960 gtttctggaa tcctttgagt attctatacc aatattattc tttgattcga atttagtttc 49020 ttcgatatta gattttgtat tacctatatt cttgatgtag tactttgatg atttttccat 49080 ggcccattct attaagtctt ccaagttggc atcatccaca tattgtgata gtaattctc g 49140 gatatcagta gcggttaccg ccattgatgt ttgttcattg gatgagtaac tactaatgta 49200 tacattttcc atttataaca cttatgtatt aactttgttc atttatattt tttcattatt 49260 atgttgatat taacaaaagt gaatatatat atgttaataa ttgtattgtg gttatacggc 49320 tacaatttta taattagtga aagtcagtgt ccgatgatca atgacgatag ctttactctg 49380 aaaagaaagt atcaaatcga tagtgcggag tcaacaataa aaatggataa gaagaggaca 49440 aagtttcaga atagagccaa aatggtaaaa gaaataaatc agacaataag agcagcacaa 49500 actcattacg agacattgaa actaggatac ataaaattta agagaatgat taggactact 49560 actctagaag atatagcacc atctattcca aataatcaga aaacttataa actattctcg 49620 gacatttcag ccatcggcaa agcatcacgg aatccaagta agatggtata tgctctgctg 49680 ctttacatgt ttcccaattt gtttggagat gatcatagat tcattcgtta tagaatgcat 49740 ccaatgagta aaatcaaaca caagatcttc tctcctttca aacttaatct tattagaata 49800 ttagtggaag aaagattcta taataatgaa tgcagatcta ataaatggag aataattgga 49860 acacaagttg ataaaatgtt gatagctgaa tctgataaat atacaataga tgcaaggtat 49920 aacctaaaac ccatgtatag aatcaaggga aaatctgaag aagataccct c tttatcaaa 49980 cagatggtag aacaatgtgt gacatcccag gaattggtgg aaaaagtgtt gaagatactg 50040 tttagagatt tgttcaagag tggagaatac aaagcgtaca gatacgatga tgatgtagaa 50100 aatggattta ttggattgga tacactaaaa ttaaacattg ttcatgatat agttgaacca 50160 tgtatgcctg ttcgtaggcc agtggctaag atactgtgta aagaaatggt aaataaatac 50220 tttgagaatc cgctacatat tattggtaaa aatcttcaag agtgcattga ctttgttagt 50280 gaataggcat ttcatctttc tccaatacta attcaaattg ttaaattaat aatggatagt 50340 ataaatagtt attagtgata aaatagtaaa aataattatt agaataagag tgtagtatca 50400 tagataactc tcttctataa aaatggattt tattcgtaga aagtatctta tatacacagt 50460 agaaaataat atagattttt taaaggatga tacattaagt aaagtaaaca attttaccct 50520 caatcatgta ctagctctca agtatctagt tagcaatttt cctcaacatg ttattactaa 50580 ggatgtatta gctaatacca atttttttgt tttcatacat atggtacgat gttgtaaagt 50640 gtacgaagcg gttttacgac acgcatttga tgcacccacg ttgtacgtta aagcattgac 50700 taagaattat ttatcgttta gtaacacaat acaatcgtac aaggaaaccg tgcataaact 50760 aacacaagat gaaaaatttt tagaggttgc caaatacatg gacg aattag gagaacttat 50820 aggcgtaaat tatgacttag ttcttaatcc attatttcac ggaggggaac ccatcaaaga 50880 tatggaaatc atttttttaa aactgtttaa gaaaacagac ttcaaagttg ttaaaaaatt 50940 aagtgttata agattactta tttgggctta cctaagcaag aaagatacag gcatagagtt 51000 tgcggataat gatagacaag atatatatac tctatttcaa caaactggta gaatcgtcca 51060 tagcaatcta acagaaacgt ttagagatta tatctttccc ggagataaga ctagctattg 51120 ggtgtggtta aacgaaagta tagctaatga tgcggatatt gttcttaata gacacgccat 51180 taccatgtat gataaaattc ttagttatat atactctgag ataaaacaag gacgcgttaa 51240 taaaaacatg cttaagttag tttatatctt tgagcctgaa aaagatatca gagaacttct 51300 gctagaaatc atatatgata ttcctggaga tatcctatct attattgatg caaaaaacga 51360 cgattggaaa aaatatttta ttagttttta taaagctaat tttattaacg gtaatacatt 51420 tattagtgat agaacgttta acgaggactt attcagagtt gttgttcaaa tagatcccga 51480 atatttcgat aatgaacgaa ttatgtcttt attctctacg agtgctgcgg acattaaacg 51540 atttgatgag ttagatatta ataacagtta tatatctaat ataatttatg aggtgaacga 51600 tatcacatta gatacaatgg atgatatgaa gaagtgt caa atctttaacg aggatacgtc 51660 gtattatgtt aaggaataca atacatacct gtttttgcac gagtcggatc ccatggtcat 51720 agagaacgga atactaaaga aactgtcatc tataaaatcc aagagtagac ggctgaactt 51780 gtttagcaaa aacattttaa aatattattt agacggacaa ttggctcgtc taggtcttgt 51840 gttagatgat tataaaggag acttgttagt taaaatgata aaccatctta agtctgtgga 51900 ggatgtatcc gcattcgttc gattttctac agataaaaac cctagtattc ttccatcgct 51960 aatcaaaact attttagcta gttataatat ttccatcatc gtcttatttc aaaggttttt 52020 aagagataat ctatatcatg tagaagaatt cttggataaa agcatccatc taaccaagac 52080 ggataagaaa tatatacttc aattgataag acacggtaga tcatagaaca gaccaaatat 52140 attattaata atttgtatat acatagatat aattatcaca tattaaaaat tcacacattt 52200 ttgataaatg ggaactgctg caacaattca gactcccacc aaattaatga ataaagaaaa 52260 tgcagaaatg attttggaaa aaattgttga tcatatagtt atgtatatta gtgacgaatc 52320 aagtgattca gaaaataatc ctgaatatat tgattttcgt aacagatacg aagactatag 52380 atctctcatt ataaaaagtg atcacgagtt tgtaaagcta tgtaaaaatc atgcagagaa 52440 aagttctcca gaaacgcaac aaatgattat caaacacata tacgaacaat atcttattcc 52500 agtatctgaa gtactattaa aacctataat gtccatgggt gacataatta catataacgg 52560 atgtaaagac aatgaatgga tgctagaaca actctctacc ctaaacttta acaatctccg 52620 cacatggaac tcatgtagca taggcaatgt aacgcgtctg ttttatacat tttttagtta 52680 tctgatgaaa gataaactaa atatataagt ataatcccat tctaatactt taacctgatg 52740 tattagcatc ttattagaat attaacctaa ctaaaagaca taacataaaa actcattaca 52800 tagttgataa aaagcggtag gatataaata ttatggctgc caccgttccg cgttttgacg 52860 acgtgtacaa aaatgcacaa agaagaattc tagatcaaga aacatttttt agtagaggtc 52920 taagtagacc gttaatgaaa aacacatatc tatttgataa ttacgcgtat ggatggatac 52980 cagaaactgc aatttggagt agtagatacg caaacttaga tgcaagtgac tattatccca 53040 tttcgttggg attacttaaa aagttcgagt ttctcatgtc tctatataaa ggtcctattc 53100 cagtatacga agaaaaagta aatactgaat tcattgctaa tggatcgttc tctggtagat 53160 acgtatcata tcttcgaaag ttttctgctc ttccaacaaa cgagtttatt agttttttgt 53220 tactgacttc cattccaatc tataatatct tgttctggtt taaaaatact cagtttgata 53280 ttactaaaca cacattattc ag atacgtct atacagataa tgccaaacac ctggcgttgg 53340 ctaggtatat gcatcaaaca ggagactata agcctttgtt tagtcgtctc aaagagaatt 53400 atatatttac cggtcccgtt ccaataggta tcaaagatat aaatcaccct aatcttagta 53460 gagcaagaag tccatccgat tatgagacat tagctaatat tagtactata ttgtacttta 53520 ccaagtatga tccggtatta atgtttttat tgttttacgt acctgggtat tcaattacta 53580 caaaaattac tccagccgta gaatatctaa tggataaact gaatctaaca aagagcgacg 53640 tacaactgtt gtaaattatt ttatgcttcg taaaatgtag gttttgaacc aaacattctt 53700 tcaaagaatg agatgcataa aactttatta tccaatagat tgactatttc ggacgtcaat 53760 cgtttaaagt aaacttcgta aaatattctt tgatcactgc cgagtttaaa acttctatcg 53820 ataattgttt catatgtttt aatatttaca agttttttgg tccatggtac attagccgga 53880 caaatatatg caaaataata tcgttctcca agttctatag tttctggatt atttttatta 53940 tattcagtaa ccaaatacat attagggtta tctgcggatt tataatttga gtgatgcatt 54000 cgactcaaca taaataattc tagaggagac gatctactat caaattcgga tcgtaaatct 54060 gtttctaaag aacggagaat atctatacat acctgattag aattcatccg tccttcagac 54120 aacatctcag acagt ctggt cttgtatgtc ttaatcatat tcttatgaaa cttggaaaca 54180 tctcttctag tttcactagt acctttatta attctctcag gtacagattt tgaattcgac 54240 gatgccgagt atttcatcgt tgtatatttc ttcttcgatt gcataatcag attcttatat 54300 accgcctcaa actctatttt aaaattatta aacaatactc tattattaat cagtcgttct 54360 aactcctttg ctatttctat ggacttatct acatcttgac tgtctatctc tgtaaacacg 54420 gagtcggtat ctccatacac gctacgaaaa cgaaatctgt aatctatagg caacgatgtt 54480 ttcacaatcg gattaatatc tctatcgtcc atataaaatg gattacttaa tggattggca 54540 aaccgtaaca taccgttaga taactctgct ccatttagta ccgattctag atacaagatc 54600 attctacgtc ctatggatgt gcaactctta gccgaagcgt atgagtatag agcactattt 54660 ctaaatccca tcagaccata tactgagttg gctactatct tgtacgtata ttgcatggaa 54720 tcatagatgg ccttttcagt tgaactggta gcctgtttta acatcttttt atatctggct 54780 ctctctgcca aaaatgttct taatagtcta ggaatggttc cttctatcga tctatcgaaa 54840 attgctattt cagagatgag gttcggtagt ctaggttcac aatgaaccgt aatatatcta 54900 ggaggtggat atttctgaag caagagctga ttatttattt cttcttccaa tctattggta 54960 ctaacaacga caccgactaa tgtttccgga gatagatttc caaagataca cacattagga 55020 tacagactgt tataatcaaa gattaataca ttattactaa acattttttg ttttggagca 55080 aataccttac cgccttcata aggaaacttt tgttttgttt ctgatctaac taagatagtt 55140 ttagtttcca acaatagctt taacagtgga cccttgatga ctgtactcgc tctatattc g 55200 aataccatgg attgaggaag cacatatgtt gacgcacccg cgtctgtttt tgtttctact 55260 ccataatact cccacaaata ctgacacaaa caagcatcat gaatacagta tctagccata 55320 tctaaagcta tgtttagatt ataatcctta tacatctgag ctaaatcaac gtcatccttt 55380 ccgaaagata atttatatgt atcattaggt aaagtaggac ataatagtac gactttaaat 55440 ccattttccc aaatatcttt acgaattact ttacatataa tatcctcatc aacagtcaca 55500 taattacctg tggttaaaac ctttgcaaat gcagcggctt tgcctttcgc gtccgtagta 55560 tcgtcaccga tgaacgtcat ttctctaact cctctattta atactttacc catgcaactg 55620 aacgcgttct tggatataga atccaatttg tacgaatcca atttttcaga tttttgaatg 55680 aatgaatata gatcgaaaaa tatagttcca ttattgttat taacgtgaaa cgtagtattg 55740 gccatgccgc ctactccctt atgactagac tgatttctct cataaataca gagatgtaca 55800 gcttcctttt tgtccggaga tctaaagata atcttctctc ctgttaataa ctctagacga 55860 ttagtaatat atctcagatc aaagttatgt ccgttaaagg taacgacata gtcgaacgtt 55920 agttccaaca attgtttagc tattcgtaac aaaactattt cagaacataa aactagttct 55980 cgttcgtaat ccatttccat tagtgactgt atcctcaaac atcctctatc g acggcttct 56040 tgtatttcct gttccgttaa catctcttca ttaatgagcg taaacaataa tcgtttacca 56100 cttaaatcga tataacagta acttgtatgc gagattgggt taataaatac agaaggaaac 56160 ttcttatcga agtgacactc tatatctaga aataagtacg atcttgggat atcgaatcta 56220 ggtatttttt tagcgaaaca gttacgtgga tcgtcacaat gataacatcc attgttaatc 56280 tttgtcaaat attgctcgtc caacgagtaa catccgtctg gagatatccc gttagaaata 56340 taaaaccaac taatattgag aaattcatcc atggtggcat tttgtatgct gcgtttcttt 56400 ggctcttcta tcaaccacat atctgcgacg gagcattttc tatctttaat atctagatta 56460 taacttattg tctcgtcaat gtctatagtt ctcatctttc ccaacggcct cgcattaaat 56520 ggaggaggag acaatgactg atatatttcg tccgtcacta cgtaataaaa gtaatgagga 56580 aatcgtataa atacggtctc accatttcga catctggatt tcagatataa aaatctgttt 56640 tcaccgtgac tttcaaacca attaatgcac cgaacatcca tttatagaat ttagaaatat 56700 attttcattt aaatgaatcc caaacattgg ggaagagccg tatggaccat tatttttata 56760 gtactttcgc aagcgggttt agacggcaac atagaagcgt gtaaacgaaa actatatact 56820 atagttagca ctcttccatg tcctgcatgt agacggcacg cgac tatcgc tatagaggac 56880 aataatgtca tgtctagcga tgatctgaat tatatttatt attttttcat cagattattt 56940 aacaatttgg catctgatcc caaatacgcg atcgatgtga caaaggttaa ccctttataa 57000 acttaaccca ttataaaact tatgattagt cacgactgaa ataaccgcgt gattattttt 57060 tggtataatt ctacacggca tggtttctgt gactatgaat tcaacccccg ttacattagt 57120 gaaatcttta acaaacagca agggttcgtc aaagacataa aactcattgt ttacaatcga 57180 aatagacccc ctatcacact taaaataaaa aatatcctta tcctttacca ccaaataaaa 57240 ttctgattgg tcaatgtgaa tgtattcact taacagttcc acaaatttat ttattaactc 57300 cgaggcacat acatcgtcgg tattttttat ggcaaacttt actcttccag catccgtttc 57360 taaaaaaata ttaacgagtt ccatttatat catccaatat tattgaaatg acgttgatgg 57420 acaaatgata caaataagaa ggtacggtac ctttgtccac catctcctcc aattcatgct 57480 ctattttgtc attaacttta atgtatgaaa acagtacgcc acatgcttcc atgacagtgt 57540 gtaacacttt ggatacaaaa tgtttgacat tagtataatt gttcaagact gtcaatctat 57600 aatagatagt agctataata tattctatga tggtattgaa gaagatgaca accttggcat 57660 attgatcatt taacacagac atggtatcaa cagatag ctt gaatgaaaga gaatcagtaa 57720 ttggaataag cgtcttctcg atggagtgtc cgtataccaa catgtctgat attttgatgt 57780 attccattaa attatttagt tttttctttt tattctcgtt aaacagcatt tctgtcaacg 57840 gaccccaaca tcgttgaccg attaagtttt gattgatttt tccgtgtaag gcgtatctag 57900 tcagatcgta tagcctatcc aataatccat cgtctgtgtg tagatcacat cgtacacttt 57960 ttaattctct atagaagagc gacagacatc tggagcaatt acagacagca atttctttat 58020 tctctacaga tgtaagatac ttgaagacat tcctatgatg atgcagaatt ttggataaca 58080 cggtattgat ggtatctgtt accataattc ctttgatggc tgatagtgtc agagcacaag 58140 atttccaatc tttgacaatt tttagcacca ttatctttgt tttgatatct atatcagaca 58200 gcatggtgcg tctgacaaca caaggattaa gacggaaaga tgaaatgatt ctctcaacat 58260 cttcaatgga taccttgcta ttttttctgg cattatctat atgtgcgaga atatcctcta 58320 gagaatcagt atcctttttg atgatagtgg atctcaatga catgggacgt ctaaaccttc 58380 ttattctatc accagattgc atggtgattt gtcttctttc ttttatcata atgtaatctc 58440 taaattcatc ggcaaattgt ctatatctaa aatcataata tgagatgttt acctctacaa 58500 atatctgttc gtccaatgtt agagtattta catcagtttt gtattccaaa ttaaacatgg 58560 caacggattt aattttatat tcctctatta agtcctcgtc gataataaca gaatgtagat 58620 aatcatttaa tccatcgtac atggttggaa gatgctcgtt gacaaaatct ttaattgtct 58680 tgatgaaggt gggactatat ctaacatctt gattaataaa atttataaca ttgtccatag 58740 gatactttgt aactagtttt atacacatct cttcatcggt aagtttagac agaatatcgt 58800 gaacaggtgg tatattatat tcatcagata tacgaagaac aatgtccaaa tctatattgt 58860 ttaatatatt atatagatgt agtgtagctc ctacaggaat atctttaact aagtcaatga 58920 tttcatcaac cgttagatct attttaaagt taatcatata ggcattgatt tttaaaaggt 58980 atgtagcctt gactacattc tcattaatta accattccaa gtcactgtgt gtaagaagat 59040 tatattctat cataagcttg actacatttg gtcccgatac cattaaagaa ttcttatgat 59100 ataaggaaac agattttagg tactcatcta ctctacaaga attttggaga gccttaacga 59160 tatcagtgac gtttattatt tcaggaggaa aaaacctaac attgagaata tcggaattaa 59220 tagcttccag atacagtgat tttggcaata gtccgtgtaa tccataatcc agtaacacga 59280 gctggtgctt gctagacacc ttttcaatgt ttaatttttt tgaaataagc tttgataaag 59340 ccttcctcgc aaattccgga ta catgaaca tgtcggcgac atgattaagt attgtttttt 59400 cattattttt atattttctc aacaagttct caatacccca atagatgata gaatatcacc 59460 caatgcgtcc atgttgtcta tttccaacag gtcgctatat ccaccaatag aagttttccc 59520 aaaaaagatt ctaggaacag ttctaccacc agtaatttgt tcaaaatagt cacgcaattc 59580 attttcgggt ttaaattctt taatatcgac aatttcatac gctcctcttt tgaaactaaa 59640 cttatttaga atatccagtg catttctaca aaaaggacat gtatacttga caaaaattgt 59700 cactttgtta ttggccaacc tttgttgtac aaattcctcg gccattttaa tatttaagtg 59760 atataaaact atctcgactt atttaactct ttagtcgaga tatatggacg cagatagcta 59820 tatgatagcc aactacagaa ggcaaacgct ataaaaaaca taattacgac gagcatattt 59880 ataaatattt ttattcagca ttacttgata tagtaatatt aggcacagtc aaacattcaa 59940 ccactctcga tacattaact ctctcatttt ctttaacaaa ttctgcaata tcttcgtaaa 60000 aagattcttg aaacttttta gaatatctat cgactctaga tgaaatagcg ttcgtcaaca 60060 tactatgttt tgtatacata aaggcgccca ttttaacagt ttctagtgac aaaatgctag 60120 cgatcctagg atcctttaga atcacataga ttgacgattc gtctctctta gtaactctag 60180 taaaataatc ataca atcta gtacgcgaaa taatattatc cttgacttga ggagatctaa 60240 acaatctagt tttgagaaca tcgataagtt catcgggaat gacatacata ctatctttaa 60300 tagaactctt ttcatccagt tgaatggatt cgtccttaac caactgatta atgagatctt 60360 ctattttatc attttccaga tgatatgtat gtccattaaa gttaaattgt gtagcgcttc 60420 tttttagtct agcagccaat actttaacat cactaatatc gatatacaaa ggagatgatt 60480 tatctatggt attaagaatt cgtttttcga catctgtcaa aaccaattcc tttttgcctg 60540 tatcatccag ttttccatcc tttgtaaaga aattattttc tactagacta ttaataagac 60600 tgataaggat tcctccataa ttgcacaatc caaacttttt cacaaaacta gactttacaa 60660 gatctacagg aatgcgtact tcaggtttct tagcttgtga ttttttcttt tgtggacatt 60720 ttcttgtgac caactcatct accatttcat tgattttagc agtgaaataa gctttcaatg 60780 cacgggcact gatactattg aaaacgagtt gatcttcaaa ttccgccatt taagttcacc 60840 aaacaacttt taaatacaaa tatatcaata gtagtagaat aagaactata aaaaaaataa 60900 taattaacca ataccaaccc caacaaccgg tattattagt tgatgtgact gttttctcat 60960 cacttagaac agatttaaca atttctataa agtctgtcaa atcatcttcc ggagacccca 61020 taaataca cc aaatatagcg gcgtacaact tatccattta tacattgaat attggctttt 61080 ctttatcgct atcttcatca tattcatcat caatatcaac aagtcccaga ttacgagcca 61140 gatcttcttc tacattttca gtcattgata cacgttcact atctccagag agtccgataa 61200 cgttagccac cacttctcta tcaatgatta gtttcttgag tgcgaatgta atttttgttt 61260 ccgttccgga tctatagaaa actacaggtg tgataattgc cttggccaat tgtctttctc 61320 ttttactgag tgattctagt tcaccttcta tagatctgag aatggatgat tctccagtcg 61380 aaacatattc taccatggct ccgtttaatt tgttgatgaa gatggattca tccttaaatg 61440 ttttctctgt aatagtttcc accgaaagac tatgcaaaga atttggaatg cgttccttgt 61500 gcttaatgtt tccatagacg gcttctagaa gttgatacaa cataggacta gccgcggtaa 61560 cttttatttt tagaaagtat ccatcgcttc tatcttgttt agatttattt ttataaagtt 61620 tagtctctcc ttccaacata ataaaagtgg aagtcatttg actagataaa ctatcagtaa 61680 gttttataga gatagacgaa caattagcgt attgagaagc atttagtgta acgtattcga 61740 tacattttgc attagattta ctaatcgatt ttgcatactc tataacaccc gcacaagtct 61800 gtagagaatc gctagatgca gtaggtcttg gtgaagtttc aactctcttc ttgattacct 61860 tactcatgat taaacctaaa taattgtact ttgtaatata atgatatata ttttcacttt 61920 atctcatttg agaataaaaa tgtttttgtt taaccactgc atgatgtaca gatttcggaa 61980 tcacaaacca ccggtggttt tattttatcc ttgtccaatg tgaattgaat gggagcggat 62040 gcgggtttcg tacgtagata gtacattccc gtttttagac cgagactcca tccgtaaaaa 62100 tgcatactcg ttagtttgga ataactcgga tctgctatat ggatattcat agattgactt 62160 tgatcgatga aggctcccct gtctgcagcc atttttatga tcgtcttttg tggaatttcc 62220 caaatagttt tataaactcg cttaatatct tctggaaggt ttgtattctg aatggatcca 62280 ccatctgcca taatcctatt cttgatctca tcattccata attttctctc ggttaaaact 62340 ctaaggagat gcggattaac tacttgaaat tctccagaca atactctccg agtgtaaata 62400 ttactggtat acggttccac cgactcatta tttcccaaaa tttgagcagt tgatgcagtc 62460 ggcataggtg ccaccaataa actatttcta agaccgtatg ttctgatttt atcttttaga 62520 ggttcccaat tccaaagatc cgacggtaca acattccaaa gatcatattg tagaataccg 62580 ttactggcgt acgatcctac atatgtatcg tatggtcctt ccttctcagc tagttcacaa 62640 ctcgcctcta atgcaccgta ataaatggtt tcgaagatct tcttatttag atcttgtgc t 62700 tccaggctat caaatggata atttaagaga ataaacgcgt ccgctaatcc ttgaacacca 62760 ataccgatag gtctatgtct cttattagag atttcagctt ctggaatagg ataataatta 62820 atatctataa ttttattgag atttctgaca attactttga ccacatcctt cagtttgaga 62880 aaatcaaatc gcccatctat tacaaacatg ttcaaggcaa cagatgccag attacaaacg 62940 gctacctcat tagcatccgc atattgtatt atctcagtgc aaagattact acacttgata 63000 gttcctaaat tttgttgatt actctttttg ttacacgcat ccttataaag aatgaatgga 63060 gtaccagttt caatctgaga ttctataatc gctttccaga cgactcgagc ctttattata 63120 gatttgtatc tcctttctct ttcgtatagt gtatacaatc gttcgaactc gtctccccaa 63180 acattgtcca atccaggaca ttcatccgga cacatcaacg accactctcc gtcatccttc 63240 actcgtttca taaagagatc aggaatccaa agagctataa atagatctct ggttctatgt 63300 tcctcgtttc ctgtattctt tttaagatcg aggaacgcca taatatcaga atgccacggt 63360 tccaagtata tggccataac tccaggccgt ttgtttcctc cctgatctat gtatctagcg 63420 gtgttattat aaactctcaa cattggaata ataccgtttg atataccatt ggtaccggag 63480 atatagcttc cactggcacg aatattacta attgatagac ctattccccc t gccatttta 63540 gagattaatg cgcatcgttt taacgtgtca tagataccct ctatgctatc atcgatcatg 63600 ttaagtagaa aacagctaga catttggtga cgactagttc ccgcattaaa taaggtagga 63660 gaagcgtgcg taaaccattt ttcagaaagt agattgtacg tctcaatagc tgagtctata 63720 tcccattgat gaattcctac tgcgacacgc attaacatgt gctgaggtct ttcaacgatc 63780 ttgttgttta ttttcaacaa gtaggatttt tccaaagttt taaaaccaaa atagttgtat 63840 gaaaagtctc gttcgtaaat aataaccgag ttgagtttat ccttatattt gttaactata 63900 tccatggtga tacttgaaat aatcggagaa tgtttcccat ttttaggatt aacatagttg 63960 aataaatcct ccatcacttc actaaatagt ttttttgttt ccttgtgtag atttgatacg 64020 gctattctgg cggctagaat ggcataatcc ggatgttgtg tagtacaagt ggctgctatt 64080 tcggctgcca gagtgtccaa ttctaccgtt gttactccat tatatattcc ttgaataacc 64140 ttcatagcta ttttaatagg atctatatga tccgtgttta agccataaca taattttcta 64200 atacgagacg tgattttatc aaacatgaca ttttccttgt atccatttcg tttaatgaca 64260 aacatttttg ttggtgtaat aaaaaaatta tttaactttt cattaatagg gatttgacgt 64320 acgtagcgta caaaatgatt gttcctggta tatagataaa gagt cctata tatttgaaaa 64380 tcgttacggc tcgattaaac tttaatgatt gcatagtgaa tatatcatta ggatttaact 64440 ccttgactat cagggcggca ccagaaatta ccatcaaaag cattaataca gttatgccta 64500 tcgcagttag aacggttata gcatccacca tttatatcta aaaattagat caaagaatat 64560 gtgacaaagt cctagttgta tattgagaat tgacaaaaca atgtttctta catatttttt 64620 ttttattagt aaccgactta atagtaggaa ctggaaaact agacttgatt attctataag 64680 tatagatacc cttccaaata atattctctt tgataaaagt tccagaaaat gtagaatttt 64740 ttaaaaagtt atcttttgct attaccaaga ttgtgtttag acgcttatta ttaatatgag 64800 tgatgaaatc cacaccgcct ctagatatcg cctttatttc cacattagat ggtaaatcca 64860 atagtgaaac tatcttttta ggaatgtatg gactcgcgtt tagaggagtg aacgtcttgg 64920 gcgtcggaaa ggatgattcg tcaaacgaat aaacaatttc acaaatggat gttaatgtat 64980 tagtaggaaa ttttttgacg ctagtggaat tgaaaattct aatggatgat gttctaccta 65040 tttcatccga taacatgtta atttccgaca ccaacggttt taatatttcg atgatatacg 65100 gtagtctctc tttcggactt atatagctta ttccacaata cgagtcatta tatactccaa 65160 aaaacaaaat aactagtata aaatctgtat cgaatgg gaa aaacgaaatt atcgacatag 65220 gtatagaatc cggaacattg aacgtattaa tacttaattc tttttctgtg gtaagtaccg 65280 ataggttatt gacattgtat ggttttaaat attctataac ttgagacttg atagatatta 65340 gtgatgaatt gaaaattatt tttatcacca cgtgtgtttc aggatcatcg tcgacgcccg 65400 tcaaccaacc gaacggagta aaataaatat cattaatata tgctctagat attagtattt 65460 ttatcaatcc tttgattatc atcttctcgt aggcgaatga ttccatgatc aagagtgatt 65520 taagaacatc ctccggagta ttaatgggct tagtaaacag tccatcgttg caataataaa 65580 agttatccaa gttaaaggat attatgcatt cgtttaaaga tatcacctca tctgacggag 65640 acaatttttt ggtaggtttt agagactttg aagctacttg tttaacaaag ttattcatcg 65700 tcgtttacta ttctatttaa ttttgtagtt aatttatcac atatcacatt aattgacttt 65760 ttggtccatt tttccatacg tttatattct tttaatcctg cgttatccgt ttccgttata 65820 tccagtgata gatcgtgcag gttaaataga atgctcttaa ataatgtcat ttttttatcc 65880 gctaaaaatt taaagaatgt ataaactttt ttcaaagatt taaaactttt aggtggtgtc 65940 ctagtacaca atatcataaa caaactaata aacatcccgc attcagattc caacagctga 66000 ttaacttcca cattaataca gcctattttc gctccaaatg tacattcgaa aaatctgaat 66060 aaaacatcaa tgtcgcaatt tgtattatcc aatacagaat gtttgtgatt cgtgttaaaa 66120 ccatcggaga aggaatagaa ataaaaatta ttatagtggt ggaattcagt tggaatattg 66180 cctccggagt cataaaagga tactaaacat tgttttttat cataaattac acatttccaa 66240 tgagacaaat aacaaaatcc aaacattaca aatctagagg tagaactttt aattttgtct 66300 ttaagtatat acgataagat atgtttattc ataaacgcgt caaatttttc atgaatcgct 66360 aaggagttta agaatctcat gtcaaattgt cctatataat ccacttcgga tccataagca 66420 aactgagaga ctaagttctt aatacttcga ttgctcatcc aggctcctct ctcaggctct 66480 attttcatct tgacgacctt tggattttca ccagtatgta ttcctttttt ttctagacac 66540 taaataaaat atttaaata taatattattat tattaaaac ttatatatatta 66 <210> 17 <211> 68308 <212> DNA <213> Artificial Sequence <220> <223> sVAC fragment 2 <400> 17 tttttttcta gacactaaat aaaatattta aaatataata ttaatgtact aaaacttata 60 tattattaat ttatctaact aaagttagta aattatatat ataattttat aattaattta 120 attttactaa ttttatttag tgtctagaaa aaaaccccct gccattttag agattaatgc 180 gcatcgtttt aacgtgtcat agataccctc tatgctatca tcgatcatgt taagtagaaa 240 acagctagac atttggtgac gactagttcc cgcattaaat aaggtaggag aagcgtgcgt 300 aaaccatttt tcagaaagta gattgtacgt ctcaatagct gagtctatat cccattgatg 360 aattcctact gcgacacgca ttaacatgtg ctgaggtctt tcaacgatct tgttgtttat 420 tttcaacaag taggattttt ccaaagtttt aaaaccaaaa tagttgtatg aaaagtctcg 480 ttcgtaaata ataaccgagt tgagtttatc cttatatttg ttaactatat ccatggtgat 540 acttgaaata atcggagaat gtttcccatt tttaggatta acatagttga ataaatcctc 600 catcacttca ctaaatagtt tttttgtttc cttgtgtaga tttgatacgg ctattctggc 660 ggctagaatg gcataatccg gatgttgtgt agtacaagtg gctgctattt cggctgccag 720 agtgtccaat tctaccgttg ttactccatt atatattcct tgaataacct tcatagctat 780 tttaatagga tctatatgat ccgtgtttaa gccataacat aattttctaa tacgagacgt 840 gattttatca a acatgacat tttccttgta tccatttcgt ttaatgacaa acatttttgt 900 tggtgtaata aaaaaattat ttaacttttc attaataggg atttgacgta cgtagcgtac 960 aaaatgattg ttcctggtat atagataaag agtcctatat atttgaaaat cgttacggct 1020 cgattaaact ttaatgattg catagtgaat atatcattag gatttaactc cttgactatc 1080 agggcggcac cagaaattac catcaaaagc attaatacag ttatgcctat cgcagttaga 1140 acggttatag catccaccat ttatatctaa aaattagatc aaagaatatg tgacaaagtc 1200 ctagttgtat attgagaatt gacaaaacaa tgtttcttac atattttttt tttattagta 1260 accgacttaa tagtaggaac tggaaaacta gacttgatta ttctataagt atagataccc 1320 ttccaaataa tattctcttt gataaaagtt ccagaaaatg tagaattttt taaaaagtta 1380 tcttttgcta ttaccaagat tgtgtttaga cgcttattat taatatgagt gatgaaatcc 1440 acaccgcctc tagatatcgc ctttatttcc acattagatg gtaaatccaa tagtgaaact 1500 atctttttag gaatgtatgg actcgcgttt agaggagtga acgtcttggg cgtcggaaag 1560 gatgattcgt caaacgaata aacaatttca caaatggatg ttaatgtatt agtaggaaat 1620 tttttgacgc tagtggaatt gaaaattcta atggatgatg ttctacctat ttcatccgat 1680 aacatgttaa tttccgaca c caacggtttt aatatttcga tgatatacgg tagtctctct 1740 ttcggactta tatagcttat tccacaatac gagtcattat atactccaaa aaacaaaata 1800 actagtataa aatctgtatc gaatgggaaa aacgaaatta tcgacatagg tatagaatcc 1860 ggaacattga acgtattaat acttaattct ttttctgtgg taagtaccga taggttattg 1920 acattgtatg gttttaaata ttctataact tgagacttga tagatattag tgatgaattg 1980 aaaattattt ttatcaccac gtgtgtttca ggatcatcgt cgacgcccgt caaccaaccg 2040 aacggagtaa aataaatatc attaatatat gctctagata ttagtatttt tatcaatcct 2100 ttgattatca tcttctcgta ggcgaatgat tccatgatca agagtgattt aagaacatcc 2160 tccggagtat taatgggctt agtaaacagt ccatcgttgc aataataaaa gttatccaag 2220 ttaaaggata ttatgcattc gtttaaagat atcacctcat ctgacggaga caattttttg 2280 gtaggtttta gagactttga agctacttgt ttaacaaagt tattcatcgt cgtttactat 2340 tctatttaat tttgtagtta atttatcaca tatcacatta attgactttt tggtccattt 2400 ttccatacgt ttatattctt ttaatcctgc gttatccgtt tccgttatat ccagtgatag 2460 atcgtgcagg ttaaatagaa tgctcttaaa taatgtcatt tttttatccg ctaaaaattt 2520 aaagaatgta taaacttttt tcaa agattt aaaactttta ggtggtgtcc tagtacacaa 2580 tatcataaac aaactaataa acatcccgca ttcagattcc aacagctgat taacttccac 2640 attaatacag cctattttcg ctccaaatgt acattcgaaa aatctgaata aaacatcaat 2700 gtcgcaattt gtattatcca atacagaatg tttgtgattc gtgttaaaac catcggagaa 2760 ggaatagaaa taaaaattat tatagtggtg gaattcagtt ggaatattgc ctccggagtc 2820 ataaaaggat actaaacatt gttttttatc ataaattaca catttccaat gagacaaata 2880 acaaaatcca aacattacaa atctagaggt agaactttta attttgtctt taagtatata 2940 cgataagata tgtttattca taaacgcgtc aaatttttca tgaatcgcta aggagtttaa 3000 gaatctcatg tcaaattgtc ctatataatc cacttcggat ccataagcaa actgagagac 3060 taagttctta atacttcgat tgctcatcca ggctcctctc tcaggctcta ttttcatctt 3120 gacgaccttt ggattttcac cagtatgtat tcctttacgt gataaatcat cgattttcaa 3180 atccatttgt gagaagtcta tcgccttaga tactttttcc cgtagtcgag gtttaaagaa 3240 atacgctaac ggtatactag taggtaactc aaaaacatca tatatagaat ggtaacgcgt 3300 ctttaactcg tcggttaact ctttcttttg atcgagttcg tcgctactat tgggtctgct 3360 caggtgcccc gactctacta gttccaacat cataccgata ggaatacaag acactttgcc 3420 ggcggttgta gatttatcat atttttccac tacatatccg ttacaatttg ttaaaaattt 3480 agatacatct atattgctac ataatccagc tagtgaatat atatgacata ataaattggt 3540 aaatcctagt tctggtattt tactaattac taaatctgta tatctttcca tttatcatgg 3600 aaaagaattt accagatatc ttcttttttc caaactgcgt taatgtattc tcttacaaat 3660 attcacaaga tgaattcagt aatatgagta aaacggaacg tgatagtttc tcattggccg 3720 tgtttccagt tataaaacat agatggcata acgcacacgt tgtaaaacat aaaggaatat 3780 acaaagttag tacagaagca cgtggaaaaa aagtatctcc tccatcacta ggaaaacccg 3840 cacacataaa cctaaccgcg aagcaatata tatacagtga acacacaata agctttgaat 3900 gttatagttt tctaaaatgt ataacaaata cagaaatcaa ttcgttcgat gagtatatat 3960 taagaggact attagaagct ggtaatagtt tacagatatt ttccaattcc gtaggtaaac 4020 gaacagatac tataggtgta ctagggaata agtatccatt tagcaaaatt ccattggcct 4080 cattaactcc taaagcacaa cgagagatat tttcagcgtg gatttctcat agacctgtag 4140 ttttaactgg aggaactgga gtgggtaaga cgtcacaggt acccaagtta ttgctttggt 4200 ttaattattt atttggtgga ttctctactc tagat aaaat cactaacttt cacgaaagac 4260 cagtcattct atctcttcct aggatagctt tagttagatt gcatagcaat accattttaa 4320 aatcattggg atttaaggta ctagatggat ctcctatttc tttacggtac ggatctatac 4380 cggaagaatt aataaacaaa caaccaaaaa aatatggaat tgtattttct acccataagt 4440 tatctctaac aaaactattt agttatggca ctcttattat agacgaagtt catgagcatg 4500 atcaaatagg agatattatt atagcagtag cgagaaagca tcatacgaaa atagattcta 4560 tgtttttaat gactgccacg ttagaggatg accgagaacg gctaaaagta tttttaccta 4620 atcccgcatt tatacatatt cctggagata cactgtttaa aattagcgag gtatttattc 4680 ataataagat aaatccatct tccagaatgg catacataga agaagaaaag agaaatttag 4740 ttactgctat acagatgtat actcctcctg atggatcatc cggtatagtc tttgtggcat 4800 ccgttgcaca gtgtcacgaa tataaatcat atttagaaaa aagattaccg tatgatatgt 4860 atattattca tggtaaggtc ttagatatag acgaaatatt agaaaaagtg tattcatcac 4920 ctaatgtatc gataattatt tctactcctt atttggaatc cagcgttact atacgcaatg 4980 ttacacacat ttatgatatg ggtaaagttt ttgtccccgc tccttttgga ggatcgcaag 5040 aatttatttc taaatctatg agagatcaac gaaaaggaag agtaggaaga gttaatcctg 5100 gtacatacgt ctatttctat gatctgtctt atatgaagtc tatacagcga atagattcag 5160 aatttctaca taattatata ttgtacgcta ataagtttaa tctaacactc cccgaagatt 5220 tgtttataat ccctacaaat ttggatattc tatggcgtac aaaggaatat atagactcgt 5280 tcgatattag tacagaaaca tggaataaat tattatccaa ttattatatg aagatgatag 5340 agtatgctaa actttatgta ctaagtccta ttctcgctga ggagttggat aactttgaga 5400 ggacgggaga attaactagt attgtacgag aagccatttt atctctaaat ttacgaatta 5460 agattttaaa ttttaaacat aaagatgatg atacgtatat acacttttgt aaaatattat 5520 tcggtgtcta taacggaaca aacgctacta tatattatca tagacctcta acgggatata 5580 tgaatatgat ttcagatact atatttgttc ctgtagataa taactaaaaa tcaaactcta 5640 atgaccacat ctttttttag agatgaaaaa ttttctacat ctccttttgt agacacgact 5700 aaacattttg caaaaaaaag tttattagtg tttagataat cgtatacttc atcagtgtag 5760 atagtaaatg tgaacaaata aaaggtattc ttactcaata gattggtaaa ttccatagaa 5820 tatattaatc ctttcttctt gagatcccac atcatttcaa ccagagacgt tttatccaat 5880 gatttacctc gtactatacc acatacaaaa ctagattttg cagtga cgtc gtacctggta 5940 ttcctaccaa acaaaatttt acttttagtt cttttagaaa attctaaggt agaatctcta 6000 tttgccaata tgtcatctat ggaattacca ctagcaaaaa atgatagaaa tatatattga 6060 tacatcgcag ctggttttga tctactatac tttaaaaacg aatcagattc cataattgcc 6120 tgtatatcat cagctgaaaa actatgtttt acacgtattc cttcggcatt tctttttaat 6180 gatatatctt gtttagacaa tgataaagtt atcatgtcca tgagagacgc gtctccgtat 6240 cgtataaata tttcattaga tgttagacgc ttcattaggg gtatacttct ataaggtttc 6300 ttaatcagtc catcattggt tgcgtcaaga actactatcg gatgttgttg ggtatctcta 6360 gtgttacaca tggccttact aaagtttggg taaataacta tgatatctct attaattata 6420 gatgcatata tttcattcgt caaggatatt agtatcgact tgctatcgtc attaatacgt 6480 gtaatgtaat catataaatc atgcgatagc caaggaaaat tcaaatagat gttcatcata 6540 taatcgtcgc tataattcat attaatacgt tgacattgac taatttgtaa tatagcctcg 6600 ccacgaagaa agctctcgta ttcagtttca tcgataaagg ataccgttaa atataactgg 6660 ttgccgatag tctcatagtc tattaagtgg taagtttcgt acaaatacag aatccctaaa 6720 atattatcta atgttggatt aatctttacc ataactgtat aaaatggaga c ggagtcata 6780 actattttac cgtttgtact tactggaata gacgaaggaa taatctccgg acatgctggt 6840 aaagacccaa atgtctgttt gaagaaatcc aatgttccag gtcctaatct cttaacaaaa 6900 attacgatat tcgatcccga tatcctttgc attctattta ccagcatatc acgaactata 6960 ttaagattat ctatcatgtc tattctccca ccgttatata aatcgcctcc gctaagaaac 7020 gttagtatat ccatacaatg gaatacttca tttctaaaat agtattcgtt ttctaattct 7080 ttaatgtgaa atcgtatact agaaagggaa aaattatctt tgagttttcc gttagaaaag 7140 aaccacgaaa ctaatgttct gattgcgtcc gattccgttg ctgaattaat ggatttacac 7200 caaaaactca tataacttct agatgtagaa gcattcgcta aaaaattagt agaatcaaag 7260 gatataagta gatgttccaa caagtgagca attcccaaga tttcatctat atcattctcg 7320 aatccgaaat tagaaattcc caagtagata tcctttttca tccgatcgtt gatgaaaata 7380 cgaactttat tcggtaagac aatcatttac taaggagtaa aataggaagt aatgttcgta 7440 tgtcgttatc atcgtataaa ttaaaggtgt gttttttacc attaagtgac attataattt 7500 taccaatatt ggaattataa tataggtgta tttgcgcact cgcgacggtt gatgcatcgg 7560 taaatatagc tgtatctaat gttctagtcg gtatttcatc atttcgctgt ctaataa tag 7620 cgttttctct atctgtttcc attacagctg cctgaagttt attggtcgga taatatgtaa 7680 aataataaga aatacatacg aataacaaaa ataaaataag atataataaa gatgccattt 7740 agagatctaa ttttgttcaa cttgtccaaa ttcctactta cagaagatga ggaatcgttg 7800 gagatagtgt cttccttatg tagaggattt gaaatatctt atgatgactt gataacttac 7860 tttccagata ggaaatacca taaatatatt tctaaagtat ttgaacatgt agatttatcg 7920 gaggaattaa gtatggaatt ccatgataca actttgcgag atttagtcta tcttagattg 7980 tacaagtatt ccaagtgtat acggccgtgt tataaattag gagataatct aaaaggcata 8040 gttgttataa aggacaggaa tatttatatt agggaagcaa atgatgactt gatagaatat 8100 ctcctcaagg aatacactcc tcagatttat acatattcta atgagcgcgt ccccataact 8160 ggttcaaaat taattctttg tggattttct caagttacat ttatggcgta tacaacgtcg 8220 catataacaa caaataaaaa ggtagatgtt ctcgtttcca aaaaatgtat agatgaacta 8280 gtcgatccaa taaattatca aatacttcaa aatttatttg ataaaggaag cggaacaata 8340 aacaaaatac tcaggaagat attttattcg gtaacaggtg gccaaactcc ataggtagct 8400 ttttctattt cggattttag aatttccaaa ttcaccagcg atttatctgt tttggtgaaa 84 60 tccaaggatt tattaatgtc cacaaatgcc atttgttttg tctgtggatt gtatttgaaa 8520 atggaaacga tgtagttaga tagatgcgct gcgaagtttc ctattagggt tccgcgcttc 8580 acgtcaccca gcatacttga atcaccatcc tttaaaaaaa atgataagat atcaacatgg 8640 agtatatcat actcggattt taattcttct actgcatcac tgacattttc acaaatacta 8700 caatacggtt taccgaaaat aatcagtacg ttcttcattt atgggtatca aaaacttaaa 8760 atcgttactg ctggaaaata aatcactgac gatattagat gataatttat acaaagtata 8820 caatggaata tttgtggata caatgagtat ttatatagcc gtcgccaatt gtgtcagaaa 8880 cttagaagag ttaactacgg tattcataaa atacgtaaac ggatgggtaa aaaagggagg 8940 gcatgtaacc ctttttatcg atagaggaag tataaaaatt aaacaagacg ttagagacaa 9000 gagacgtaaa tattctaaat taaccaagga cagaaaaatg ctagaattag aaaagtgtac 9060 atccgaaata caaaatgtta ccggatttat ggaagaagaa ataaaggcag aaatgcaatt 9120 aaaaatcgat aaactcacat ttcaaatata tttatctgat tctgataaca taaaaatatc 9180 attgaatgag atactaacac atttcaacaa taatgagaat gttacattat tttattgtga 9240 tgaacgagac gcagaattcg ttatgtgtct cgaggctaaa acacatttct ctaccacagg 9300 aga atggccg ttgataataa gtaccgatca ggatactatg ctatttgcat ctgctgataa 9360 tcatcctaag atgataaaaa acttaactca actgtttaaa tatgttccat ctgcagagga 9420 taactattta gcaaaattaa cggcgttagt gaatggatgt gatttctttc ctggactcta 9480 tggggcatct ataacaccca acaacttaaa caaaatacaa ttgtttagtg attttacaat 9540 cgataatata gtcactagtt tggcaattaa aaattattat agaaagacta actctaccgt 9600 agacgtgcgt aatattgtta cgtttataaa cgattacgct aatttagacg atgtctactc 9660 gtatattcct ccttgtcaat gcactgttca agaatttata ttttccgcat tagatgaaaa 9720 atggaatgaa tttaaatcat cttatttaga aagcgtgccg ttaccctgcc aattaatgta 9780 tgcgttagaa ccacgcaagg agattgatgt ttcagaagtt aaaactttat catcttatat 9840 agatttcgaa aatactaaat cagatatcga tgttataaaa tctatatcct cgatcttcgg 9900 atattctaac gaaaactgta acacgatagt attcggcatc tataaggata atttactact 9960 gagtataaat agttcatttt actttaacga tagtctgtta ataaccaata ctaaaagtga 10020 taatataata aatataggtt actagattaa aaatggtgtt ccaactcgtg tgctctacgt 10080 gcggcaaaga tatttctcac gaacgatata aattgattat acgaaaaaaa tcattaaagg 10140 atgtac tcgt cagtgtaaag aacgaatgtt gtaggttaaa attatctaca caaatagaac 10200 ctcaacgtaa cttaacagtg caacctctat tggatataaa ctaatatgga tccggttaat 10260 tttatcaaga catatgcgcc tagaggttct attattttta ttaattatac catgtcatta 10320 acaagtcatt tgaatccatc gatagaaaaa catgtgggta tttattatgg tacgttatta 10380 tcggaacact tggtagttga atcaacatat agaaaaggag ttcgaatagt cccattggat 10440 agtttttttg aaggatatct tagtgcaaaa gtatacatgt tagagaatat tcaagttatg 10500 aaaatagcag ctgatacgtc attaacttta ttgggtattc cgtatggatt tggtcatgat 10560 agaatgtatt gttttaaatt ggtagctgac tgttataaaa atgccggtat tgatacatcg 10620 tctaaacgaa tattaggtaa agatattttt ctgagccaaa acttcacaga cgataataga 10680 tggataaaga tatatgattc taataattta acattttggc aaattgatta ccttaaaggg 10740 tgagttaata tgcataacta ctcctccgtt gttttttccc tcgttctttt tcttaacgtt 10800 gtttgccatc actctcataa tgtaaagata ttctaaaatg gtaaactttt gcatatcgga 10860 cgcagaaatt ggtataaatg ttgtaattgt attatttccc gtcaatggac tagtcacagc 10920 tccatcagtt ttatatcctt tagagtattt ctcactcgtg tctaacattc tagagcattc 1098 0 catgatctgt ttatcgttga tattggccgg aaagatagat tttttatttt ttattatatt 11040 actattggca attgtagata taacttctgg taaatatttt tctacctttt caatctcttc 11100 tattttcaag ccggctatat attctgctat attgttgcta gtatcaatac cttttctggc 11160 taagaagtca tatgtggtat tcactatatc agttttaact ggtagttcca ttagcctttc 11220 cacttctgca gaataatcag aaattggttc tttaccagaa aatccagcta ctataatagg 11280 ctcaccgatg atcattggca aaatcctata ttgtaccaga ttaatgagag catatttcat 11340 ttccaataat tctgctagtt cttgagacat tgatttattt gatgaatcta gttggttctc 11400 tagatactct accatttctg ccgcatacaa taacttgtta gataaaatca gggttatcaa 11460 agtgtttagc gtggctagaa tagtgggctt gcatgtatta aagaatgcgg tagtatgagt 11520 aaaccgtttt aacgaattat atagtctcca gaaatctgtg gcgttacata catgagccga 11580 atgacatcga agattgtcca atatttttaa tagctgctct ttgtccatta tttctatatt 11640 tgactcgcaa caattgtaga taccattaat caccgattcc tttttcgatg ccggacaata 11700 gcacaattgt ttagctttgg actctatgta ttcagaatta atagatatat ctcttaatac 11760 agattgcact atacattttg aaactatgtc aaaaattgta gaacgacgct gttctgc agc 11820 catttaactt taaataattt acaaaaattt aaaatgagca tccgtataaa aatcgataaa 11880 ctgcgccaaa ttgtggcata tttttcagag ttcagtgaag aagtatctat aaatgtagac 11940 tcgacggatg agttaatgta tatttttgcc gccttgggcg gatctgtaaa catttgggcc 12000 attatacctc tcagtgcatc agtgttctac cgcggagccg aaaatattgt gtttaatctt 12060 cctgtgtcca aggtaaaatc gtgtttgtgt agttttcaca atgatgccat catagatata 12120 gaacctgatc tggaaaataa tctagtaaaa ctttctagtt atcatgtagt aagtgtcgat 12180 tgtaataagg aactgatgcc tattaggaca gatactacta tttgtctaag tatagatcaa 12240 aagaaatctt acgtgtttaa ttttcacaag tatgaagaaa aatgttgtgg tagaaccgtc 12300 attcatttag aatggttgtt gggctttatc aagtgtatta gtcagcatca gcatttggct 12360 attatgttta aagatgacaa tattattatg aagactcctg gtaatactga tgcattttcc 12420 agggaatatt ctatgactga atgttctcaa gaactacaaa agttttcttt caaaatagct 12480 atctcgtctc tcaacaaact acgaggattc aaaaagagag tcaatgtttt tgaaactaga 12540 atcgtaatgg ataatgacga taacatttta ggaatgttgt tttcggatag agttcaatcc 12600 tttaagatca acatctttat ggcgttttta gattaatact ttcaatgaga taaatatggg 12660 tggcggagta agtgttgagc tccctaaacg ggatccgcct ccgggagtac ccactgatga 12720 gatgttatta aacgtggata aaatgcatga cgtgatagct cccgctaagc ttttagaata 12780 tgtgcatata ggaccactag caaaagataa agaggataaa gtaaagaaaa gatatccaga 12840 gtttagatta gtcaacacag gacccggtgg tctttcggca ttgttaagac aatcgtataa 12900 tggaaccgca cccaattgct gtcgcacttt taatcgtact cattattgga agaaggatgg 12960 aaagatatca gataagtatg aagagggtgc agtattagaa tcgtgttggc cagacgttca 13020 cgacaccgga aaatgcgatg ttgatttatt cgactggtgt cagggggata cgttcgatag 13080 aaacatatgc catcagtgga tcggttcagc ctttaatagg agtaatagaa ctgtagaggg 13140 tcaacaatcg ttaataaatc tgtataataa gatgcaaaca ttatgtagta aagatgctag 13200 tgtaccaata tgtgaatcat ttttgcatca tttacgcgca cacaatacag aagatagcaa 13260 agagatgatc gattatattc taagacaaca gtctgcggac tttaaacaga aatatatgag 13320 atgtagttat cccactagag ataagttaga agagtcatta aaatatgcgg aacctcgaga 13380 atgttgggat ccagagtgtt cgaatgccaa tgttaatttc ttgctaacac gtaattataa 13440 taatttagga ctttgcaata ttgtacgatg taatactagc gt gaacaact tacagatgga 13500 taaaacttcc tcattaagat tgtcatgtgg attaagcaat agtgatagat tttctactgt 13560 tcccgtcaat agagcaaaag tagttcaaca taatattaaa cacttactttcg acctaaat cattatta agtatatgg ataggt agtatatgg gggtgccgcg gcaagcatac agacgacggt gaatacactc agcgaacgta tctcgtctaa 13740 attagaacaa gaagcgaatg ctagtgctca aacaaaatgt gatatagaaa tcggaaattt 13800 ttatatccga caaaaccatg gatgtaacct cactgttaaa aatatgtgct ctgcggacgc 13860 ggatgctcag ttggatgctg tgttatcagc cgctacagaa acatatagtg gattaacacc 13920 ggaacaaaaa gcatacgtgc cagctatgtt tactgctgcg ttaaacattc agacgagtgt 13980 aaacactgtt gttagagatt ttgaaaatta tgtgaaacag acttgtaatt ctagcgcggt 14040 cgtcgataac aaattaaaga tacaaaacgt aatcatagat gaatgttacg gagccccagg 14100 atctccaaca aatttggaat ttattaatac aggatctagc aaaggaaatt gtgccattaa 14160 ggcgttgatg caattgacga ctaaggccac tactcaaata gcacctaaac aagttgctgg 14220 tacaggagtt cagttttata tgattgttat cggtgttata atattggcag cgttgtttat 14280 gtactatgcc aagcgtatgt tgttcacatc caccaatgat aaaatcaaac ttattttagc 14340 caataaggaa aacgtccatt ggactactta catggacaca ttctttagaa cttctccgat 14400 ggttattgct accacggata tgcaaaactg aaaatatatt gataatattt taatagatta 14460 acatggaagt tatcactgat cgtctagacg atatagtgaa acaaaatata gcggatgaa a 14520 aatttgtaga ttttgttata cacggtctag agcatcaatg tcctgctata cttcgaccat 14580 taattaggtt gtttattgat atactattat ttgttatagt aatttatatt tttacggtac 14640 gtctagtaag tagaaattat caaatgttgt tggcgttggt ggcgctagtc atcacattaa 14700 ctatttttta ttactttata ctataatagt actagactga cttctaacaa acatctcacc 14760 tgccataaat aaatgcttga tattaaagtc ttctatttct aacactattc catctgtgga 14820 aaataatact ctgacattat cgctaattga cacatcggtg agtgatatgc ctataaagta 14880 ataatcttct ttgggcacat ataccagtgt accaggttct aacaacctat ttactggtgc 14940 tcctatagca tactttttct ttaccttgag aatatccatc gtttgcttgg tcaatagcga 15000 tatgtgattt tttatcaacc actcgaaaaa gtaattggag tgttcatatc ctctacgggc 15060 tattgtctca tggccgtgta tgaaatttaa gtaacacgac tgtggtagat ttgttctata 15120 gagccggttg ccgcaaatag atagaactac caatatgtct gtacaaatgt taaacattaa 15180 ttgattaaca gaaaaaacaa tgttcgttct gggaatagaa accagatcaa aacaaaattc 15240 gttagaatat atgccacgtt tatacattga atataaaata actacagttt gaaaaataac 15300 agtatcattt aaacatttaa cttgcggggt taatctcaca actttactgt t tttgaactg 15360 ttcaaaatat agcatagatc cgtgagaaat acgtttagcc gcctttaata gaggaaatcc 15420 caccgccttt ctggatctca ccaacgacga tagttctgac cagcaactca tttcttcatc 15480 atccacctgt tttaacatat aataggcagg agatagatat ccgtcattgc aatattcctt 15540 ctcgtaggca cacaatctaa tattgataaa atctccattc tcttctctgc atttattatc 15600 ttgtttcggt ggctgattag gctgtagtct tggtttaggc tttggtatat cgttgttgaa 15660 tctattttgg tcattaaatc tttcatttct tcctggtata tttttatcac ctcgtttggt 15720 tggatttttg tctatattat cgtttgtaac atcggtacgg gtattcattt atcacaaaaa 15780 aaacttctct aaatgagtct actgctagaa aacctcatcg aagaagatac catatttttt 15840 gcaggaagta tatctgagta tgatgattta caaatggtta ttgccggcgc aaaatccaaa 15900 tttccaagat ctatgctttc tatttttaat atagtaccta gaacgatgtc aaaatatgag 15960 ttggagttga ttcataacga aaatatcaca ggagcaatgt ttaccacaat gtataatata 16020 agaaacaatt tgggtctagg agatgataaa ctaactattg aagccattga aaactatttc 16080 ttggatccta acaatgaagt tatgcctctt attattaata atacggatat gactgccgtc 16140 attcctaaaa aaagtggtag gagaaagaat aagaacatgg ttat cttccg tcaaggatca 16200 tcacctatct tgtgtatttt cgaaactcgt aaaaagatta atatttataa agaaaatatg 16260 gaatccgcgt cgactgagta tacacctatc ggagacaaca aggctttgat atctaaatat 16320 gcgggaatta atatcctaaa tgtgtattct ccttccacat ccataagatt gaatgccatt 16380 tacggattca ccaataaaaa taaactagag aaacttagta ctaataagga actagaatcg 16440 tatagttcta gccctcttca agaacccatt aggttaaatg attttctggg actattggaa 16500 tgtgttaaaa agaatattcc tctaacagat attccgacaa aggattgatt actataaatg 16560 gagaatgttc ctaatgtata ctttaatcct gtgtttatag agcccacgtt taaacattct 16620 ttattaagtg tttataaaca cagattaata gttttatttg aagtattcgt tgtattcatt 16680 ctaatatatg tattttttag atctgaatta aatatgttct tcatgcctaa acgaaaaata 16740 cccgatccta ttgatagatt acgacgtgct aatctagcgt gtgaagacga taaattaatg 16800 atctatggat taccatggat gacaactcaa acatctgcgt tatcaataaa tagtaaaccg 16860 atagtgtata aagattgtgc aaagcttttg cgatcaataa atggatcaca accagtatct 16920 cttaacgatg ttcttcgcag atgatgattc attttttaag tatttggcta gtcaagatga 16980 tgaatcttca ttatctgata tattgcaaat cactcaa tat ctagactttc tgttattatt 17040 attgatccaa tcaaaaaata aattagaagc cgtgggtcat tgttatgaat ctctttcaga 17100 ggaatacaga caattgacaa aattcacaga ctttcaagat tttaaaaaac tgtttaacaa 17160 ggtccctatt gttacagatg gaagggtcaa acttaataaa ggatatttgt tcgactttgt 17220 gattagtttg atgcgattca aaaaagaatc ctctctagct accaccgcaa tagatcctgt 17280 tagatacata gatcctcgtc gcaatatcgc attttctaac gtgatggata tattaaagtc 17340 gaataaagtg aacaataatt aattctttat tgtcatcatg aacggcggac atattcagtt 17400 gataatcggc cccatgtttt caggtaaaag tacagaatta attagacgag ttagacgtta 17460 tcaaatagct caatataaat gcgtgactat aaaatattct aacgataata gatacggaac 17520 gggactatgg acgcatgata agaataattt tgaagcattg gaagcaacta aactatgtga 17580 tgtcttggaa tcaattacag atttctccgt gataggtatc gatgaaggac agttctttcc 17640 agacattgtt gaattctgtg agcgtatggc aaacgaagga aaaatagtta tagtagccgc 17700 actcgatggg acatttcaac gtaaaccgtt taataatatt ttgaatctta ttccattatc 17760 tgaaatggtg gtaaaactaa ctgctgtgtg tatgaaatgc tttaaggagg cttccttttc 17820 taaacgattg ggtgaggaaa ccgagataga aataatagga ggtaatgata tgtatcaatc 17880 ggtgtgtaga aagtgttaca tcgactcata atattatatt ttttatctaa aaaactaaaa 17940 ataaacattg attaaatttt aatataatac ttaaaaatgg atgttgtgtc gttagataaa 18000 ccgtttatgt attttgagga aattgataat gagttagatt acgaaccaga aagtgcaaat 18060 gaggtcgcaa aaaaactgcc gtatcaagga cagttaaaac tattactagg agaattattt 18120 tttcttagta agttacagcg acacggtata ttagatggtg ccaccgtagt gtatatagga 18180 tctgctcccg gtacacatat acgttatttg agagatcatt tctataattt aggagtgatc 18240 atcaaatgga tgctaattga cggccgccat catgatccta ttttaaatgg attgcgtgat 18300 gtgactctag tgactcggtt cgttgatgag gaatatctac gatccatcaa aaaacaactg 18360 catccttcta agattatttt aatttctgat gtgagatcca aacgaggagg aaatgaacct 18420 agtacggcgg atttactaag taattacgct ctacaaaatg tcatgattag tattttaaac 18480 cccgtggcgt ctagtcttaa atggagatgc ccgtttccag atcaatggat caaggacttt 18540 tatatcccac acggtaataa aatgttacaa ccttttgctc cttcatattc agctgaaatg 18600 agattattaa gtatttatac cggtgagaac atgagactga ctcgagttac caaatcagac 18660 gctgtaaatt atgaaaaaaa ga tgtactac cttaataaga tcgtccgtaa caaagtagtt 18720 gttaactttg attatcctaa tcaggaatat gactattttc acatgtactt tatgctgagg 18780 accgtgtact gcaataaaac atttcctact actaaagcaa aggtactatt tctacaacaa 18840 tctatatttc gtttcttaaa tattccaaca acatcaactg aaaaagttag tcatgaacca 18900 atacaacgta aaatatctag caaaaattct atgtctaaaa acagaaatag caagagatcc 18960 gtacgcagta ataaatagaa acgtactact gagatatact accgatatag agtataatga 19020 tttagttact ttaataaccg ttagacataa aattgattct atgaaaactg tgtttcaggt 19080 atttaacgaa tcatccataa attatactcc ggttgatgat gattatggag aaccaatcat 19140 tataacatcg tatcttcaaa aaggtcataa caagtttcct gtaaattttc tatacataga 19200 tgtggtaata tctgacttat ttcctagctt tgttagacta gatactacag aaactaatat 19260 agttaatagt gtactacaaa caggcgatgg taaaaagact cttcgtcttc ccaaaatgtt 19320 agagacggaa atagttgtca agattctcta tcgccctaat ataccattaa aaattgttag 19380 atttttccgc aataacatgg taactggagt agagatagcc gatagatctg ttatttcagt 19440 cgctgattaa tcaattagta gagatgagat aagaacatta taataatcaa taatatatct 19500 tatatctcgt ttaga aaaat gctaatatta aaatagctaa cgctagtaat ccaatcggaa 19560 gccatttgat atctataata gggtatctaa tttcctgatt cagatagcgg acagctatat 19620 tctcggtagc tactcgtttg gaatcacaaa cattatttac atctaattta ctatctgtaa 19680 tggaaacgtt tcccaatgaa atggtacaat ccgatacatt gcattttgtt atattttttt 19740 ttaaagaggc tggtaacaac gcatcgcttc gtttacatgg ctcgtaccaa caataatagg 19800 gtaatcttgt atctattcct atccgtacta tgcttttatc aggataaata catttacatc 19860 gtatatcgtc tttgttagca tcacagaatg cataaatttg ttcgtccgtc atgataaaaa 19920 tttaaagtgt aaatataact attattttta tagttgtaat aaaaagggaa atttgattgt 19980 ataccttcgg ttctttaaaa gaaactgact tgataaaaat ggctgtaatc tctaaggtta 20040 cgtatagtct atatgatcaa aaagagatta atgctacaga tattatcatt agtcatgtta 20100 aaaatgacga cgatatcggt accgttaaag atggtagact aggtgctatg gatggggcat 20160 tatgtaagac ttgtgggaaa acggaattgg aatgtttcgg tcactggggt aaagtaagta 20220 tttataaaac tcatatagtt aagcctgaat ttatttcaga aattattcgt ttactgaatc 20280 atatatgtat tcactgcgga ttattgcgtt cacgagaacc gtattccgac gatattaacc 20340 taaaagag tt atcgggacac gctcttagga gattaaagga taaaatatta tccaagaaaa 20400 agtcatgttg gaacagtgaa tgtatgcaac cgtatcaaaa aattactttt tcaaagaaaa 20460 aggtttgttt cgtcaacaag ttggatgata ttaacgttcc taattctctc atctatcaaa 20520 agttaatttc tattcatgaa aagttttggc cattattaga aattcatcaa tatccagcta 20580 acttatttta tacagactac tttcccatcc ctccgttgat tattagaccg gctattagtt 20640 tttggataga tagtataccc aaagaaacca atgaattaac ttacttatta ggtatgatcg 20700 ttaagaattg taacttgaat gctgatgaac aggttatcca gaaggcggta atagaatacg 20760 atgatattaa aattatttct aataacactt ccagtatcaa tttatcatat attacatccg 20820 gcaaaaataa tatgattaga agttatatcg tcgcccgacg aaaagatcag acggctagat 20880 ctgtaattgg tcccagtaca tctatcaccg ttaatgaggt aggaatgccc gcatatatta 20940 gaaatacact tacagaaaag atatttgtta atgcctttac agtggataaa gttaaacaac 21000 tattagcatc aaaccaagtt aaattttact ttaataaacg attaaaccaa ttaacaagaa 21060 tacgccaagg aaagtttatc aaaaataaaa tacatttatt gcctggtgat tgggtagaag 21120 tagctgttca agaatataca agtattattt ttggaagaca gccgtctcta catagataca 21180 acgtcatcgc ttcatctatc agagctaccg aaggagatac tatcaaaata tctcccggaa 21240 ttgccaactc tcaaaatgct gatttcgacg gagatgaaga atggatgata ttagaacaaa 21300 atcctaaagc tgtaattgaa caaagtattc ttatgtatcc gacgacgtta ctcaaacacg 21360 atattcatgg agcccccgtt tatggatcta ttcaagatga aatcgtagca gcgtattcat 21420 tgtttaggat acaagatctt tgtttagatg aagtattgaa catcttgggg aaatatggaa 21480 gagagttcga tcctaaaggt aaatgtaaat tcagcggtaa agatatctat acttacttga 21540 taggtgaaaa gattaattat ccgggtctct taaaggatgg tgaaattatt gcaaacgacg 21600 tagatagtaa ttttgttgtg gctatgaggc atctgtcatt ggctggactc ttatccgatc 21660 ataagtcgaa cgtggaaggt atcaacttta ttatcaagtc atcttatgtt tttaagagat 21720 atctatctat ttacggtttt ggggtgacat tcaaagatct gagaccaaat tcgacgttca 21780 ctaataaatt ggaggccatc aacgtagaaa aaatagaact tatcaaagaa gcatacgcca 21840 aatatctcaa cgatgtaaga gacgggaaaa tagttccatt atctaaagct ttagaggcgg 21900 actatgtgga atccatgtta tccaacttga caaatcttaa tatccgagag atagaagaac 21960 atatgagaca aacgctgata gatgatccag ataataacct cctgaaaatg gccaaagcg g 22020 gttataaagt aaatcctaca gaactaatgt atattctagg tacgtatgga caacaaagga 22080 ttgatggtga accagcagag actcgagtat tgggtagagt cttaccttac tatcttccag 22140 actctaagga tccagaagga agaggttaca ttcttaattc tttaacaaaa ggattaacag 22200 gttctcaata ttacttttcg atgctggttg caagatctca atctactgat atcgtctgtg 22260 aaacatcacg taccggaaca ctggctagaa aaatcattaa aaagatggag gatatggtgg 22320 tcgacggata cggacaagta gttataggta atacgctcat caagtacgcc gccaattata 22380 ccaaaattct aggctcagta tgtaaacctg tagatcttat ctatccagat gagtccatga 22440 cttggtattt ggaaattagt gctctgtgga ataaaataaa acagggattc gtttactctc 22500 agaaacagaa acttgcaaag aagacattgg cgccgtttaa tttcctagta ttcgtcaaac 22560 ccaccactga ggataatgct attaaggtta aggatctgta cgatatgatt cataacgtca 22620 ttgatgatgt gagagagaaa tacttcttta cggtatctaa tatagatttt atggagtata 22680 tattcttgac gcatcttaat ccttctagaa ttagaattac aaaagaaacg gctatcacta 22740 tctttgaaaa gttctatgaa aaactcaatt atactctagg tggtggaact cctattggaa 22800 ttatttctgc acaggtattg tctgagaagt ttacacaaca agccctgtcc a gttttcaca 22860 ctactgaaaa aagtggtgcc gtcaaacaaa aacttggttt caacgagttt aataacttga 22920 ctaatttgag taagaataag accgaaatta tcactctggt atccgatgat atctctaaac 22980 ttcaatctgt taagattaat ttcgaatttg tatgtttggg agaattaaat ccagacatca 23040 ctcttcgaaa agaaacagat aggtatgtag tagatataat agtcaataga ttatacatca 23100 agagagcaga aattaccgaa ttagtcgtcg aatatatgat tgaacgattc atctccttta 23160 gcgtcattgt aaaggaatgg ggtatggaaa cattcattga ggacgaggat aatattagat 23220 ttactgtcta tctaaatttc gttgaaccag aggaattgaa tcttagtaag tttatgatgg 23280 ttcttccggg ggcagccaac aagggaaaga ttagtaaatt caagattcct atctctgatt 23340 atacgggtta tgacgacttc aatcaaacaa aaaagctcaa taagatgact gtagaactca 23400 tgaatctaaa agaattaggt tctttcgatt tggaaaacgt caacgtgtat cctggagtat 23460 ggaatacata cgatatcttc ggtatcgagg ccgctcgtga atacttgtgc gaagccatgt 23520 taaacaccta tggagaaggg ttcgattatc tgtatcagcc ttgtgatctt ctcgctagtt 23580 tactatgtgc tagttacgaa ccagaatcag tgaataaatt caagttcggc gcagctagta 23640 ctcttaagag agctacgttc ggagacaata aagcattgtt aaac gcggct cttcataaaa 23700 agtcagaacc tattaacgat aatagtagct gccacttttt tagcaaggtc cctaatatag 23760 gaactggata ttacaaatac tttatcgact tgggtcttct catgagaatg gaaaggaaac 23820 tatctgataa gatatcttct caaaagatca aggaaatgga agaaacagaa gacttttaat 23880 tcttatcaat aacatatttt tctatgatct gtcttttaaa cgatggattt tccacaaatg 23940 cgcctctcaa gtccctcata gaatgataca cgtataaaaa atatagcata ggcaatgact 24000 ccttattttt agacattaga tatgccaaaa tcatagcccc gcttctattt actcccgcag 24060 cacaatgaac caacacgggc tcgtttcgtt gatcacattt agataaaaag gcggttacgt 24120 cgtcaaaata tttactaata tcggtagttg tatcatctac caacggtata tgaataatat 24180 taatattaga gttaggtaat gtatatttat ccatcgtcaa atttaaaaca tatttgaact 24240 taacttcaga tgatggtgca tccatagcat ttttataatt tcccaaatac acattattgg 24300 ttacccttgt cattatagtg ggagatttgg ctctgtgcat atctccagtt gaacgtagta 24360 gtaagtattt atacaaactt ttcttatcca tttataacgt acaaatggat aaaactactt 24420 tatcggtaaa cgcgtgtaat ttagaatacg ttagagaaaa ggctatagta ggcgtacaag 24480 cagccaaaac atcaacactt atattctttg ttattat att ggcaattagt gcgctattac 24540 tctggtttca gacgtctgat aatccagtct ttaatgaatt aacgagatat atgcgaatta 24600 aaaatacggt taacgattgg aaatcattaa cggatagcaa aacaaaatta gaaagtgata 24660 gaggtagact tctagccgct ggtaaggatg atatattcga attcaaatgt gtggatttcg 24720 gcgcctattt tatagctatg cgattggata agaaaacata tctgccgcaa gctattaggc 24780 gaggtactgg agacgcgtgg atggttaaaa aggcggcaaa ggtcgatcca tctgctcaac 24840 aattttgtca gtatttgata aaacacaagt ctaataatgt tattacttgt ggtaatgaga 24900 tgttaaatga attaggttat agcggttatt ttatgtcacc gcattggtgt tccgatttta 24960 gtaatatgga atagtgttag ataaatgcgg taacgaatgt tcctgtaagg aaccataaca 25020 gtttagattt aacgttaaag atgagcataa acataataaa caaaattaca atcaaaccta 25080 taacattaat atcaaacaat ccaaaaaatg aaatcagtgg agtagtaaac gcgtacataa 25140 ctcctggata acgtttagta gctgccgttc ctattctaga ccaaaaattc ggtttcatgt 25200 tttcgaaacg gtgttctgca acaagtcggg gatcgtgttc tacatatttg gcggcattat 25260 ccagtatctg cctattgatc ttcatttcgt tttcaattct ggctatttca aaataaaatc 25320 ccgatgatag acctccagac tttataattt catctacgat gttcagcgcc gtagtaactc 25380 taataatata ggctgataag ctaacatcat accctcctgt atatgtgaat atggcatgat 25440 ttttgtccat tacaagctcg gttttaactt tattgcctgt aataatttct ctcatctgta 25500 ggatatctat ttttttgtca tgcattgcct tcaagacggg acgaagaaac gtaatatcct 25560 caataacgtt atcgttttct acaataacta catattctac ctttttattt tctaactcgg 25620 taaaaaaatt agaatcccat agggctaaat gtctagcgat atttcttttc gtttcctctg 25680 tacacatagt gttacaaaac cctgaaaaga agtgagtata cttgtcatca tttctaatgt 25740 ttcctccagt ccactgtata aacgcataat ccttgtaatg atctggatca tccttgacta 25800 ccacaacatt tcttttttct ggcataactt cgttgtcctt tacatcatcg aacttctgat 25860 cattaatatg ctcatgaaca ttaggaaatg tttctgatgg aagtctatca ataactggca 25920 caacaataac aggagttttc gccgccgcca tttagttatt gaaattaatc atatacaact 25980 ctttaatacg agttatattt tcgtctatcc attgtttcac atttacatat ttcgacaaaa 26040 agatataaaa tgcgtattcc aatgcttctc tgtttaatga attactaaaa tatacaaaca 26100 cgtcactgtc tggcaataaa tgatatctta gaatattgta acaatttatt ttgtattgca 26160 catgttcgtg atctatgagt tc ttcttcga atggcatagg atctccgaat ctgaaaacgt 26220 ataaatagga gttagaataa taatatttga gagtattggt aatatataaa ctctttagcg 26280 gtataattag tttttttctc tcaatttcta tttttagatg tgatggaaaa atgactaatt 26340 ttgtagcatt agtatcatga actctaatca aaatcttaat atcttcgtca cacgttagct 26400 ctttgaagtt tttaagagat gcatcagttg gttcgaccga tggagtaggt gcaacaattt 26460 tttgttcgat gtatgtatgt actggagcca ttgttttaac tataatggtg cttgtatcga 26520 aaaactttaa tgcagatagc ggaagctctt cgccgcgact ttctacatcg taattgggtt 26580 ctaacgccga tctctgaatg gatactagtt ttctaagttc taatgtgatt ctctgaaaat 26640 gtaaatccaa ttcctccggc attatagatg tgtatacatc ggtaaataaa actatagtat 26700 ccaacgatcc cttctcgcaa attctagtct taaccaaaaa atcgtatata accacggaga 26760 tggcgtattt aagagtggat tcttctaccg ttttgttctt ggatgtcata taggaaacta 26820 taaagtccgc actactgtta agaatgatta ctaacgcaac tatatagttc aaattaagca 26880 ttttggaaac ataaaataac tctgtagacg atacttgact ttcgaataag tttgcagaca 26940 aacgaagaaa gaacagacct ctcttaattt cagaagaaaa ctttttttcg tattcctgac 27000 gtctagagtt tatat caata agaaagttaa gaattagtcg gttaatgttg tatttcatta 27060 cccaagtttg agatttcata atattatcaa aagacatgat aatattaaag ataaagcgct 27120 gactatgaac gaataatagattcta tatggttgtcgc tatta caggttgtcattacta tataggattagatattacta tatta tcaattagttcgc agta gtcatatagttaat cacacactct acaatatgcc acaccatctt cataataaat aaattcgtta gcaaaattat 27300 taattttagt gaaatagtta gcgtcaactt tcatagcttc cttcaatcta atttgatgct 27360 cacacggtgc gaattccact ctaacatccc ttttccatgc ctcaggttca tcgatctcta 27420 taatatctag ttttttgcgt ttcacaaaca caggctcgtc tctcgcgatg agatctgtat 27480 agtaactatg taaatgataa ctagatagaa agatgtagct atatagatga cgatccttta 27540 agagaggtat aataacttta ccccaatcag atagactgtt gttatggtct tcggaaaaag 27600 aatttttata aatttttcca gtattttcca aatatacgta cttaacatct aaaaaatcct 27660 taatgataat aggaatggat aatccgtcta ttttataaag aaatacatat cgcacattat 27720 actttttttt ggaaatggga ataccgatgt gtctacataa atatgcaaag tctaaatatt 27780 ttttagagaa tcttaattgg tccaaattct tttccaagta cggtaataga tttttcatat 27840 tgaacggtat cttcttaatc tctggttcta gttccgcatt aaatgatgaa actaagtcac 27900 tatttttata actaacgatt acatcacctc taacatcatc atttaccaga atactgatct 27960 tcttttgtcg taaatacatg tctaatgtgt taaaaaaaag atcatacaag ttatacgtca 28020 tttcatctgt ggtattcttg tcattgaagg ataaactcgt actaatctct tctttaaca g 28080 cctgttcaaa tttatatcct atatacgaaa aaatagcaac cagtgtttga tcatccgcgt 28140 caatattctg ttctatcgta gtgtataaca atcgtatatc ttcttctgtg atagtcgata 28200 cgttataaag gttgataacg aaaatatttt tatttcgtga aataaagtca tcgtaggatt 28260 ttggacttat attcgcgtct agtagatatg cttttatttt tggaatgatc tcaattagaa 28320 tagtctcttt agagtccatt taaagttaca aacaactagg aaattggttt atgatgtata 28380 atttttttag tttttataga ttctttattc tatacttaaa aaatgaaaat aaatacaaag 28440 gttcttgagg gttgtgttaa attgaaagcg agaaataatc ataaattatt tcattatcgc 28500 gatatccgtt aagtttgtat cgtaatggcg tggtcaatta caaataaagc ggatactagt 28560 agcttcacaa agatggctga aatcagagct catctaaaaa atagcgctga aaataaagat 28620 aaaaacgagg atattttccc ggaagatgta ataattccat ctactaagcc caaaaccaaa 28680 cgagccacta ctcctcgtaa accagcggct actaaaagat caaccaaaaa ggaggaagtg 28740 gaagaagaag tagttataga ggaatatcat caaacaactg aaaaaaattc tccatctcct 28800 ggagtcagcg acattgtaga aagcgtggcc gctgtagagc tcgatgatag cgacggggat 28860 gatgaaccta tggtacaagt tgaagctggt aaagtaaatc atagtgctag a agcgatctc 28920 tctgacctaa aggtggctac cgacaatatc gttaaagatc ttaagaaaat tattactaga 28980 atctctgcag tatcgacggt tctagaggat gttcaagcag ctggtatctc tagacaattt 29040 acttctatga ctaaagctat tacaacacta tctgatctag tcaccgaggg aaaatctaaa 29100 gttgttcgta aaaaagttaa aacttgtaag aagtaaatgc gtgcactttt ttataaagat 29160 ggtaaactct ttaccgataa taatttttta aatcctgtat cagacgataa tccagcgtat 29220 gaggttttgc aacatgttaa aattcctact catttaacag atgtagtagt atatgaacaa 29280 acgtgggagg aggcgttaac tagattaatt tttgtgggaa gtgattcaaa aggacgtaga 29340 caatactttt acggaaaaat gcatgtacag aatcgcaacg ctaaaagaga tcgtattttt 29400 gttagagtat ataacgttat gaaacgaatt aattgtttta taaacaaaaa tataaagaaa 29460 tcgtccacag attccaatta tcagttggcg gtttttatgt taatggaaac tatgtttttt 29520 attagatttg gtaaaatgaa atatcttaag gagaatgaaa cagtagggtt attaacacta 29580 aaaaataaac acatagaaat aagtcccgat gaaatagtta tcaagtttgt aggaaaggac 29640 aaagtttcac atgaatttgt tgttcataag tctaatagac tatataagcc gctattgaaa 29700 ctgacggatg attctagtcc cgaagaattt ctgttcaaca aact aagtga acgaaaggta 29760 tatgaatgta tcaaacagtt tggtattaga atcaaggatc tccgaacgta tggagtcaat 29820 tatacgtttt tatataattt ttggacaaat gtaaagtcca tatctcctct tccatcacca 29880 aaaaagttaa tagcgttaac tatcaaacaa actgctgaag tggtaggtca tactccatca 29940 atttcaaaaa gagcttatat ggcaacgact attttagaaa tggtaaagga taaaaatttt 30000 ttagatgtag tatctaaaac tacgttcgat gaattcctat ctatagtcgt agatcacgtt 30060 aaatcatcta cggatggatg atatagatct ttacacaaat aattacaaaa ccgataaatg 30120 gaaatggata agcgtatgaa atctctcgca atgaccgctt tctttgggga gctaagcaca 30180 ttagatatta tggcattgat aatgtctata tttaaacgcc atccaaacaa taccattttt 30240 tcagtggata aggatggtca gtttatgatt gatttcgaat acgataatta taaggcttct 30300 caatatttgg atctgaccct cactccgata tctggagatg aatgcaagac tcacgcatcg 30360 agtatagccg aacaattggc gtgtgtggat attattaaag aggatattag cgaatatatc 30420 aaaactactc cccgtcttaa acgatttata aaaaaatacc gcaatagatc agatactcgc 30480 atcagtcgag atacagaaaa gcttaaaata gctctagcta aaggcataga ttacgaatat 30540 ataaaagacg cttgttaata agtaaatgaa aaaaaac tag tcgtttataa taaaacacga 30600 tatggatgcc aacgtagtat catcttctac tattgcgacg tatatagacg ctttagcgaa 30660 gaatgcttcg gaattagaac agaggtctac cgcatacgaa ataaataatg aattggaact 30720 agtatttatt aagccgccat tgattacttt gacaaatgta gtgaatatct ctacgattca 30780 ggaatcgttt attcgattta ccgttactaa taaggaaggt gttaaaatta gaactaagat 30840 tccattatct aaggtacatg gtctagatgt aaaaaatgta cagttagtag atgctataga 30900 taacatagtt tgggaaaaga aatcattagt gacggaaaat cgtcttcaca aagaatgctt 30960 gttgagacta tcgacagagg aacgtcatat atttttggat tacaagaaat atggatcctc 31020 tatccgacta gaattagtca atcttattca agcaaaaaca aaaaacttta cgatagactt 31080 taagctaaaa tattttctag gatccggtgc ccagtctaaa agttctttat tacacgctat 31140 taatcatcca aagtcaaggc ctaatacatc tctggaaata gaatttacac ctagagacaa 31200 tgaaacagtt ccatatgatg aactaataaa ggaattgacg actctctcgc gtcatatatt 31260 tatggcttct ccagagaatg taattctttc tccgcctatt aacgcgccta taaaaacctt 31320 tatgttgcct aaacaagata tagtaggttt ggatctggaa aatctatatg ccgtaactaa 31380 gactgacggc attcctataa ctatcagagt tacatcaaac gggttgtatt gttattttac 31440 acatcttggt tatattatta gatatcctgt taagagaata atagattccg aagtagtagt 31500 ctttggtgag gcagttaagg ataagaactg gaccgtatat ctcattaagc taatagagcc 31560 tgtgaatgca atcaatgata gactagaaga aagtaagtat gttgaatcta aactagtgga 31620 tatttgtgat cggatagtat tcaagtcaaa gaaatacgaa ggtccgttta ctacaactag 31680 tgaagtcgtc gatatgttat ctacatattt accaaagcaa ccagaaggtg ttattctgtt 31740 ctattcaaag ggacctaaat ctaacattga ttttaaaatt aaaaaggaaa atactataga 31800 ccaaactgca aatgtagtat ttaggtacat gtccagtgaa ccaattatct ttggagagtc 31860 gtctatcttt gtagagtata agaaatttag caacgataaa ggctttccta aagaatatgg 31920 ttctggtaag attgtgttat ataacggcgt taattatcta aataatatct attgtttgga 31980 atatattaat acacataatg aagtgggtat taagtccgtg gttgtaccta ttaagtttat 32040 agcagaattc ttagttaatg gagaaatact taaacctaga attgataaaa ccatgaaata 32100 tattaactca gaagattatt atggaaatca acataatatc atagtcgaac atttaagaga 32160 tcaaagcatc aaaataggag atatctttaa cgaggataaa ctatcggatg tgggacatca 32220 atacgccaat aatgataaat tt agattaaa tccagaagtt agttatttta cgaataaacg 32280 aactagagga ccgttgggaa ttttatcaaa ctacgtcaag actcttctta tttctatgta 32340 ttgttccaaa acatttttag acgattccaa caaacgaaag gtattggcga ttgattttgg 32400 aaacggtgct gacctggaaa aatactttta tggagagatt gcgttattgg tagcgacgga 32460 tccggatgct gatgctatag ctagaggaaa tgaaagatac aacaaattaa actctggaat 32520 taaaaccaag tactacaaat ttgactacat tcaggaaact attcgatccg atacatttgt 32580 ctctagtgtc agagaagtat tctattttgg aaagtttaat atcatcgact ggcagtttgc 32640 tatccattat tcttttcatc cgagacatta tgctaccgtc atgaataact tatccgaact 32700 aactgcttct ggaggcaagg tattaatcac taccatggac ggagacaaat tatcaaaatt 32760 aacagataaa aagactttta taattcataa gaatttacct agtagcgaaa actatatgtc 32820 tgtagaaaaa atagctgatg atagaatagt ggtatataat ccatcaacaa tgtctactcc 32880 aatgactgaa tacattatca aaaagaacga tatagtcaga gtgtttaacg aatacggatt 32940 tgttcttgta gataacgttg atttcgctac aattatagaa cgaagtaaaa agtttattaa 33000 tggcgcatct acaatggaag atagaccatc tacaagaaac tttttcgaac taaatagagg 33060 agccattaaa tgtga aggtt tagatgtcga agacttactt agttactatg ttgtttatgt 33120 cttttctaag cggtaaataa taatatggta tgggttctga tctcccagtt ctaaatgcat 33180 taaataattc caatagagcg atttttgttc ctataggacc ttccaactgt ggatactctg 33240 tattgttaat agatatatta atacttttgt cgggtaacag aggttctacg tcttttaaaa 33300 ataaaagttt gataacatct ggcctgttca taaataaaaa cttggcgatt ctatatatac 33360 tcttattatc aaatctagcc attgtcttat agatgtgagc tactgtaggt gtaccatttg 33420 attttctttc taatactata tatttctctc gaagaagttc ttgcacatca tctgggaata 33480 aaatactact gttgagtaaa tcagttattt tttttatatc gatattgatg gacattttta 33540 tagttaagga taataagtat cccaaagtag ataacgacga taacgaagta tttatacttt 33600 taggaaatca caatgacttt atcagattaa aattaacaaa attaaaggag catgtatttt 33660 tttctgaata tattgtgact ccagatacat atggatcttt atgcgtcgaa ttaaatgggt 33720 ctagttttca gcacggcggt agatatatag aggtggagga atttatagat gctggaagac 33780 aagttagatg gtgttctaca tccaatcata tatctaaaga tatacccgaa gatatgcaca 33840 ctgataaatt tgtcatttat gatatataca cttttgacgc tttcaagaat aaacgattgg 33900 tattcgta ca ggtacctccg tcgttaggag atgatagtca tttgactaat ccgttattgt 33960 ctccgtatta tcgtaattca gtagccagac aaatggtcaa tgatatgatt tttaatcaag 34020 attcattttt aaaatattta ttagaacatc tgattagaag ccactataga gtttctaaac 34080 atataacaat agttagatac aaggataccg aagaattaaa tctaacgaga atatgttata 34140 atagagataa gtttaaggcg tttgtattcg cttggtttaa cggcgtttcg gaaaatgaaa 34200 aggtactaga tacgtataaa aaggtatcta atttgatata atgaattcag tgactgtatc 34260 acacgcgcca tatactatta cttatcacga tgattgggaa ccagtaatga gtcaattggt 34320 agagttttat aacgaagtag ccagttggct gctacgagac gagacgtcgc ctattcctga 34380 taagttcttt atacagttga aacaaccgct tagaaataaa cgagtatgtg tgtgcggtat 34440 agatccgtat ccgaaagatg gaactggtgt accgttcgaa tcaccaaatt ttacaaaaaa 34500 atcaattaag gagatagctt catctatatc tagattaacc ggagtaattg attataaagg 34560 ttataacctt aatataatag acggggttat accctggaat tattacttaa gttgtaaatt 34620 aggagaaaca aaaagtcacg cgatctactg ggataagatt tccaagttac tgctgcagca 34680 tataactaaa cacgttagtg ttctttattg tttgggtaaa acagatttct cgaatatacg 34740 ggccaagtta gaatccccgg taactaccat agtcggatat catccagcgg ctagagaccg 34800 ccaattcgag aaagatagat catttgaaat tatcaacgtt ttactggaat tagacaacaa 34860 ggcacctata aattgggctc aagggtttat ttattaatgc tttagtgaaa ttttaacttg 34920 tgttctaaat ggatgcggct attagaggta atgatgttat ctttgttctt aagactatag 34980 gtgtcccgtc agcgtgcaga caaaatgaag atccaagatt tgtagaagca tttaaatgcg 35040 acgagttaga aagatatatt gagaataatc cagaatgtac actattcgaa agtcttaggg 35100 atgaggaagc atactctata gtcagaattt tcatggatgt agatttagac gcgtgtctag 35160 acgaaataga ttatttaacg gctattcaag attttattat cgaggtgtca aactgtgtag 35220 ctagattcgc gtttacagaa tgcggcgcca ttcatgaaaa tgtaataaaa tccatgagat 35280 ctaatttttc attgactaag tctacaaata gagataaaac aagttttcat attatctttt 35340 tagacacgta taccactatg gatacattga tagctatgaa acgaacacta ttagaattaa 35400 gtagatcatc tgaaaatcca ctaacaagat cgatagacac tgccgtatat aggagaaaaa 35460 caactcttcg ggttgtaggt actaggaaaa atccaaattg cgacactatt catgtaatgc 35520 aaccaccgca tgataatata gaagattacc tattcactta cgtggatatg aacaacaat a 35580 gttattactt ttctctacaa caacgattgg aggatttagt tcctgataag ttatgggaac 35640 cagggtttat ttcattcgaa gacgctataa aaagagtttc aaaaatattc attaattcta 35700 taataaactt taatgatctc gatgaaaata attttacaac ggtaccactg gtcatagatt 35760 acgtaacacc ttgtgcatta tgtaaaaaac gatcgcataa acatccgcat caactatcgt 35820 tggaaaatgg tgctattaga atttacaaaa ctggtaatcc acatagttgt aaagttaaaa 35880 ttgttccgtt ggatggtaat aaactgttta atattgcaca aagaatttta gacactaact 35940 ctgttttatt aaccgaacga ggagaccata tagtttggat taataattca tggaaattta 36000 acagcgaaga acccttgata acaaaactaa ttttgtcaat aagacatcaa ctacctaagg 36060 aatattcaag cgaattactc tgtccaagaa aacgaaagac tgtagaagct aacatacgag 36120 acatgttagt agattcagta gagaccgata cctatccgga taaacttccg tttaaaaatg 36180 gtgtattgga cctggtagac ggaatgtttt actctggaga tgatgctaaa aaatatacgt 36240 gtactgtatc aaccggattt aaatttgacg atacaaagtt cgtcgaagac agtccagaaa 36300 tggaagagtt aatgaatatc attaacgata tccaaccatt aacggatgaa aataagaaaa 36360 atagagagct atatgaaaaa acattatcta gttgtttatg cggtgctacc a aaggatgtt 36420 taacattctt ttttggagaa actgcaactg gaaagtcgac aaccaaacgt ttgttaaagt 36480 ctgctatcgg tgacctgttt gttgagacgg gtcaaacaat tttaacagat gtattggata 36540 aaggacctaa tccatttatc gctaacatgc atttgaaaag atctgtattc tgtagcgaac 36600 tacctgattt tgcctgtagt ggatcaaaga aaattagatc tgacaatatt aaaaagttga 36660 cagaaccttg tgtcattgga agaccgtgtt tctccaataa aattaataat agaaaccatg 36720 cgacaatcat tatcgatact aattacaaac ctgtttttga taggatagat aacgcattaa 36780 tgagaagaat tgccgtcgtg cgattcagaa cacacttttc tcaaccttct ggtagagagg 36840 ctgctgaaaa taatgacgcg tacgataaag tcaaactatt agacgagggg ttagatggta 36900 aaatacaaaa taatagatat agattcgcat ttctatactt gttggtgaaa tggtacagaa 36960 aatatcatgt tcctattatg aaactatatc ctacacccga agagattcct gactttgcat 37020 tctatctcaa aataggtact ctgttagtat ctagctctgt aaagcatatt ccattaatga 37080 cggacctctc caaaaaggga tatatattgt acgataatgt ggtcactctt ccgttgacta 37140 ctttccaaca gaaaatatcc aagtatttta attctagact atttggacac gatatagaga 37200 gcttcatcaa tagacataag aaatttgcca atgttagtga tgaa tatctg caatatatat 37260 tcatagagga tatttcatct ccgtaaatat atgctcatat atttatagaa gatatcacat 37320 atctaaatga ataccggaat catagattta tttgataatc atgttgatag tataccaact 37380 atattacctc atcagttagc tactctagat tatctagtta gaactatcat agatgagaac 37440 agaagcgtgt tattgttcca tattatggga tcaggtaaaa caataatcgc tttgttgttc 37500 gccttggtag cttccagatt taaaaaggtt tacattctag tgcctaatat caacattttg 37560 aaaattttta attataatat gggtgtagct atgaacttgt ttaatgacga attcatagct 37620 gagaatatct ttattcattc cacaacaagt ttttattctc ttaattataa cgataacgtc 37680 attaattata acggattatc tcgctacaat aactctattt ttatcgttga tgaggcacat 37740 aatatctttg ggaataatac tggagaactt atgaccgtga taaaaaataa aaacaagatt 37800 ccttttctac tattgtctgg atctcccatt actaacacac ctaatactct gggtcatatt 37860 atagatttaa tgtccgaaga gacgatagat tttggtgaga ttattagtcg tggtaagaaa 37920 gtaattcaga cacttcttaa cgaacgcggt gtgaatgtac ttaaggattt gcttaaagga 37980 agaatatcat attacgaaat gcctgataaa gatctaccaa cgataagata tcacggacgt 38040 aagtttctag atactagagt agtatattgt cacatgt cta aacttcaaga gagagattat 38100 atgattacta gacgacagct atgttatcat gaaatgtttg ataaaaatat gtataacgtg 38160 tcaatggcag tattgggaca acttaatctg atgaataatt tagatacttt atttcaggaa 38220 caggataagg aattgtaccc aaatctgaaa ataaataatg gcgtgttata cggagaagaa 38280 ttggtaacgt taaacattag ttccaaattt aaatacttta ttaatcggat acagacactc 38340 aacggaaaac attttatata cttttctaat tctacatatg gcggattggt aattaaatat 38400 atcatgctca gtaatggata ttctgaatat aatggttctc agggaactaa tccacatatg 38460 ataaacggca aaccaaaaac atttgctatc gttactagta aaatgaaatc gtctttagag 38520 gatctattag atgtgtataa ttctcctgaa aacgatgatg gtagtcaatt gatgtttttg 38580 ttttcgtcaa acattatgtc cgaatcctat actctgaaag aggtaaggca tatttggttt 38640 atgactatcc cagatacttt ttctcaatac aaccaaattc ttggacgatc tattagaaaa 38700 ttctcttacg ccgatatttc tgaaccagtt aatgtatatc ttttagccgc cgtatattcc 38760 gatttcaatg acgaagtaac gtcattaaac gattacacac aggatgaatt gattaatgtt 38820 ttaccatttg acatcaaaaa gctgttatat ctaaaattta agactaaaga aacgaataga 38880 atatactcta ttcttcaaga gatgtctgaa acgtattctc ttccaccaca tccatcaatt 38940 gtaaaagttt tattgggaga attggtcaga caattttttt ataataattc tcgtattaag 39000 tataacgact ccaagttact taaaatggtt acatcagtta taaaaaataa agaagacgct 39060 aggaattaca tagatgatat tgtaaacggt cacttctttg tatcgaataa agtatttgat 39120 aaatctcttt tatacaaata cgaaaacgat attattacag taccgtttag actttcctac 39180 gaaccatttg tttggggagt taactttcgt aaagaatata acgtggtatc ttctccataa 39240 aactgatgaa atatataaag aaataaatgt cgagctttgt taccaatgga taccttccag 39300 ttacattgga accacacgag ctgacgttag acataaaaac taatattagg aatgccgtat 39360 ataagacgta tctccataga gaaattagtg gtaaaatggc caagaaaata gaaattcgtg 39420 aagacgtgga attacctctc ggcgaaatag ttaataattc tgtagttata aacgttccgt 39480 gtgtaataac ctacgcgtat tatcacgttg gggatatagt cagaggaaca ttaaacatcg 39540 aagatgaatc aaatgtaact attcaatgtg gagatttaat ctgtaaacta agtagagatt 39600 cgggtactgt atcatttagc gattcaaagt actgcttttt tcgaaatggt aatgcgtatg 39660 acaatggcag cgaagtcact gccgttctaa tggaggctca acaaggtatc gaatctagtt 39720 ttgtttttct cgcgaatatc gt cgactcat aaaaaagaga atagcggtaa gtataaacac 39780 gaatactatg gcaataattg cgaatgtttt attctcttcg atatattttt gataatatga 39840 aaaacatgtc tctctcaaat cggacaacca tctcataaaa tagttctcgc gcgctggaga 39900 ggtagttgct gctcgtataa tctccccaga ataatatact tgcgtgtcgt cgttcaattt 39960 atacggattt ctatagttct ctgttatata atgcggtttt ccatcatgat tagacgacga 40020 caatagtgtt ctgaatttag atagttgatc agaatgaatg tttattggcg ttggaaaaat 40080 tatccataca gcgtctgcag agtggttgat agttgttcct agatatgtaa aataatccaa 40140 cttactaggc agcaaattgt ctagataaaa tactgaatca aacggtgcag acgtattggc 40200 ggatctaatg gaatccaatt gattaactat cttttgaaaa tatacatttt tatgatccaa 40260 tacttgtaag aatatagaaa taatgataag tccatcatcg tgtttttttg cctcttcata 40320 agaactatat tttttcttat tccaatgaac aagattaatc tctccagagt atttgtacac 40380 atctatcaag tgattggatc cataatcgtc ttcctttccc caatatatat gtagtgatga 40440 taacacatat tcattgggga gaaaccctcc acttatatat cctcctttaa aattaatcct 40500 tactagtttt ccagtgttct ggatagtggt tggtttcgac tcattataat gtatgtctaa 40560 cggcttcaat cgcgc gttag aaattgcttt tttagtttct atattaatag gagatagttg 40620 ttgcggcata gtaaaaatga aatgataact gtttaaaaat agctcttagt atgggaatta 40680 caatggatga ggaactagtgata tattaga ttttgaagtagtgata tattaga ttttgaagta atccgttaat aggagctaga agaacttcat tcgcgttcca ggcgatatta tctcaacaaa 40860 attcagattc tatctttaga gtatccacta aactattacg gtttatgtac tacaatgaac 40920 taagagaaat ctttagacgg ttgagaaaag gttctatcaa caatatcgat cctcactttg 40980 aagagttaat attattgggt ggtaaactag ataaaaagga atctattaaa gattgtttaa 41040 gaagagaatt aaaagaggaa agtgatgaac gtataacagt aaaagaattc ggaaatgtaa 41100 ttctaaaact tacaacgcgc gataaattat ttaataaagt atatataggt tattgcatgg 41160 cgtgttttat taatcaatcg ttggaggatt tatcgcatac tagtatttac aatgtagaaa 41220 ttagaaagat taaatcatta aatgattgta ttaacgacga taaatacgaa tatctgtctt 41280 atatttataa tatgctagtt aatagtaaat gaacttttac agatctagta taattagtca 41340 gattattaag tataatagac gactagctaa gtctattatt tgcgaggatg actctcaaat 41400 tattacactc acggcattcg ttaaccaatg cctatggtgt cataaacgag tatccgtgtc 41460 cgctatttta ttaactactg ataacaaaat attagtatgt aacagacgag atagttttct 41520 ctattctgaa ataattagaa ctagaaacat gtttagaaag aaacgattat ttctgaatta 41580 ttccaattat ttgaacaaac aggaaagaag tatactatcg tcattttttt ctctagatc c 41640 agctactgct gataatgata gaatagacgc tatttatccg ggtggcatac ccaaaagggg 41700 tgagaatgtt ccagagtgtt tatccaggga aattaaagaa gaagttaata tagacaattc 41760 ttttgtattc atagacactc ggttttttat tcatggcatc atagaagata ccattattaa 41820 taaatttttt gaggtaatct tctttgtcgg aagaatatct ctaacgagtg atcaaatcat 41880 tgatacattt aaaagtaatc atgaaatcaa ggatctaata tttttagatc cgaattcagg 41940 taatggactc caatacgaaa ttgcaaaata tgctctagat actgcaaaac tcaaatgtta 42000 tggccataga ggatgttatt acgaatcatt aaaaaaatta actgaggatg attgattaga 42060 aaatataaat taatttacca tcgtgtattt ttataacggg attgtccggc atatcatgta 42120 gatagttacc gtctacatcg tatactcgac catctacgcc tttaaatcct ctatttattg 42180 acattaatct attagaattg gaataccaaa tattagtacc ctcaattagt ttattggtaa 42240 tatttttgtt agacgataga tcgatggctc ttgaaaccaa ggttttccaa ccggactcat 42300 tgtcgatcgg tgagaagtct ttttcattag catgaatcca ttctaatgat gtatgtttaa 42360 acactctaaa caattggaca aattcttttg atttgctttg aatgatttca aataggtctt 42420 cgtctacagt aggcatacca ttagataatc tagccattat aaagtgcacg t ttacatatc 42480 tacgttctgg aggagtaaga acgtgactat tgagacgaat ggctcttcct actatctgac 42540 gaagagacgc ctcgttccat gtcatatcta aaatgaagat atcattgatt gagaagaagc 42600 taataccctc gcctccacta gaagagaata cgcatgtttt aatgcattct ccgttagtgt 42660 ttgattcttg gttaaactca gccaccgcct tgattctagt atcttttgtt ctagatgaga 42720 actctatatt agagatacca aagactttga aatatagtaa taagatttct attcctgact 42780 gattaacaaa tggttcaaag actagacatt taccatggga tgctaatatt cccaaacata 42840 catctataaa tttgacgctt ttctctttta attcagtaaa tagagagata tcagccgcac 42900 tagcatcccc tcccaatagt tctccccttt taaaggtatc taatgcagat ttagaaaatt 42960 ctctatctct taatgaattt ttaaaatcat tatatagtgt tgctatctct tgcgcgtatt 43020 cgcccggatc acgattttgt ctttcaggaa agctatcgaa cgtaaacgta gtagccatac 43080 gtctcagaat tctaaatgat gatatacctg tttttatttc agcgagttta gccttttgat 43140 aaatttcttc ttgctttttc gacatattaa cgtatcgcat taatactgtt ttcttagcga 43200 atgatgcaga cccttctacg tcatcaaaaa tagaaaactc gttattaact atgtacgaac 43260 ataggcctcc tagtttggag actaattctt tttcatcaac taga cgttta ttctcaaata 43320 gcgattggtg ttgtaaggat cctggtcgta gtaagttaac caacatggtg aattcttgca 43380 cactattgac gataggtgta gccgataaac aaatcatctt atggtttttt aatgcgatgg 43440 tcttagataa aaaattatat actgaacgag taggacggat cttaccatct tctttgatta 43500 atgatttaga aatgaagtta tgacattcat caataatgac gcatattcta ctcttggaat 43560 taatagtttt gatattagta aaaaatttat ttctaaaatt ttgatcatcg taattaataa 43620 aaatacaatc cttcgttatc tctggagcgt atctgagtat agtgttcatc caaggatctt 43680 ctatcaaagc ctttttcacc aataagataa tagcccaatt cgtataaata tccttaagat 43740 gtttgagaat atatacagta gtcattgttt taccgacacc cgtttcatgg aacaataaaa 43800 gagaatgcat actgtctaat cctaagaaaa ctcttgctac aaaatgttga taatccttga 43860 ggcgtactac gtccgacccc atcatttcaa caggcatatt agtagttctg cgcaatgcat 43920 aatcgatata ggccgcgtgt gatttactca tttatgagtg ataagtaata actatgtttt 43980 aaaaatcaca gcagtagttt aactagtctt ctctgatgtt tgttttcgat actttttgaa 44040 tcagaagtca tactagaata aagcaacgag tgaacgtaat agagagcttc gtatactcta 44100 ttcgaaaact ctaagaactt attaatgaat tccgtat cca ctggattgtt taaaatacta 44160 aattgaacac tgttcacatc cttccaagaa gaagacttag tgacggactt aacatgagac 44220 ataaataaat ccaaattttt tttacaaaca tcactagcca ccataatggc gctatctttt 44280 aaccagctat cgcttacgca ttttagcagt ctaacatttt taaagagact acaatatatt 44340 ctcatagtat cgattacacc tctaccgaat aaagttggaa gtttaataat acaatatttt 44400 tcgtttacaa aatcaaataa tggtcgaaac acgtcgaagg ttaacatctt ataatcgcta 44460 atgtatagat tgttttcagt gagatgatta ttagatttaa tagcatctcg ttcacgtttg 44520 aacagtttat tgcgtgcgct gaggtcggca actacggcgt ccgctttagt actcctccca 44580 taatacttta cgctattaat ctttaaaatt tcatagactt tatctagatc gctttctggt 44640 aacatgatat catgtgtaaa aagttttaac atgtcggtcg gcattctatt tagatcatta 44700 actctagaaa tctgaagaaa gtaattagct ccgtattcca gactaggtaa tgggctttta 44760 cctagagaca gattaagttc tggcaatgtt tcataaaatg gaagaaggac atgcgttccc 44820 tcccggatat tttttacaat ttcatccatt tacaactcta tagtttgttt tcattattat 44880 tagttattat ctcccataat cttggtaata cttacccctt gatcgtaaga taccttatac 44940 aggtcattac atacaactac caattgtttt tgtacataat agattggatg gttgacatcc 45000 atggtggaat aaactactcg aacagatagt ttatctttcc ccctagatac attagccgta 45060 atagttgtcg gcctaaagaa tatctttggt gtaaagttaa aagttagggt tcttgttcca 45120 ttattgcttt ttgtcagtag ttcattataa attctcgaga tgggtccgtt ctctgaatat 45180 agaacatcat ttccaaatct aacttctagt ctagaaataa tatcggtctt attcttaaaa 45240 tctattccct tgatgaaggg atcgttaatg aacaaatcct tggcctttga ttcggctgat 45300 ctattatctc cgttatagac gttacgttga ctagtccaaa gacttacagg aatagatgta 45360 tcgatgatgt tgatactatg tgatatgtga gcaaagattg ttctcttagt ggcatcacta 45420 tatgttccag taatggcgga aaacttttta gaaatgttat atataaaaga attttttcgt 45480 gttccaaaca ttagcagatt agtatgaaga taaacactca tattatcagg aacattatca 45540 atttttacat acacatcagc atcttgaata gaaacgatac catcttctgg aacctctacg 45600 atctcggcag actccggata accagtcggt ggaccatcgc taacaataac tagatcatcc 45660 aacaatctac tcacatatgc atctatataa tctttttcat cttgtgagta ccctggatac 45720 gaaataaatt tattatccgt atttccataa taaggtttag tataaacaga gagcgatgtt 45780 gccgcatgaa cttcagttac ag tcgccgtt ggttggttta tttgacctat tactctccta 45840 ggtttctcta taaatgatgg tttaatttgt acattcttaa ccatatatcc aataaagctc 45900 aattcaggaa cataaacaaa ttctttgttg aacgtttcaa agtcgaacga agagtcacga 45960 ataacgatat cggatactgg attgaaggtt accgttacgg taatttttga atcggatagt 46020 ttaagactgc tgaatgtatc ttccacatca aacggagttt taatataaac gtatactgta 46080 gatggttctt taatagtgtc attaggagtt aggccaatag aaatatcatt aagttcacta 46140 gaatatccag agtgtttcaa agcaattgta ttattgatac aattattata taattcttcg 46200 ccctcaattt cccaaataac accgttacac gaagagatag atacgtgatt aatacattta 46260 tatccaacat atggtacgta accgaatctt cccatacctt taacttctgg aagttccaaa 46320 ctcagaacca aatgattaag cgcagtaata tactgatccc taatttcgaa gctagcgata 46380 gcctgattgt ctggaccatc gtttgtcata actccggata gagaaatata ttgcggcata 46440 tataaagttg gaatttgact atcgactgcg aagacattag accgtttaat agagtcatcc 46500 ccaccgatca aagaattaat gatagtatta ttcattttct atttaaaatg gaaaaagctt 46560 acaataaact ccgtagagaa atatctataa tttgtgagtt ttccttaaag taacagcttc 46620 cgtaaacgcc gtctt tatct cttagtaagt ttattgtatt tataaccttt tccttatctt 46680 catagaatac taaaggcaac aaagaaattt ttggttcttc tctaagagct acgtgagact 46740 taaccataga cgccaacgaa tccctacata ttttagaaca gaaataccca acttcaccac 46800 ccttgaatgt ctcaatacta ataggtttaa aaaccaaatc ttgattacaa aaccaacact 46860 tatcaattac actatttgtc ttaatagaca catctgccat agatttataa tactttggta 46920 gtatacaagc gagtgcttct tctttagcgg gcttaaagac tgctttaggt gctgaaataa 46980 ccacatctgg aaggcttact cgcttagcca tttaattacg gaactatttt tttatacttc 47040 taatgagcaa gtagaaaacc tctcatctac aaaaacatac tcgtgtccat aatcctctac 47100 catagttaca cgttttttag atctcatatg tgctaaaaag ttttcccata ctaattggtt 47160 actattattt ttcgtataat ttttaacagt ttgaggtttt agatttttag ttacagaagt 47220 gatatcgaat attttatcca aaaagaatga ataattaatt gtcttagaag gagtgttttc 47280 ttggcaaaag aataccaagt gcttaaatat ttctactact tcattaatct tttctgtact 47340 cagattcagt ttctcatctt ttacttgatt gattatttca aagactaact tataatcctt 47400 tttatttatt ctctcgttag ccttaagaaa actagataca aaatttgcat ctacatcatc 47460 cgtggata tt tgattttttt ccatgatatc caagagttcc gagataattt ctccagaaca 47520 ttgatgagac aataatctcc gcaatacatt tctcaaatga ataagtttat tagacacatg 47580 gaagtttgac tttttttgta cctttgtaca tttttgaaat accgactcgc aaaaaataca 47640 atattcatat ccttgttcag atactatacc gttgtgtcta caaccgctac ataatcgtag 47700 attcatgtta acactctacg tatctcgtcg tccaatattt tatataaaaa cattttattt 47760 ctagacgttg ccagaaaatc ctgtaatatt tttagttttt tgggctgtga ataaagtatc 47820 gccctaatat tgttaccgtc ttccgccaat atagtagtta aattatccgc acatgcaaaa 47880 gaacaccgct taggcggatt cagtacaatg ttatattttt cgtaccaact catttaaata 47940 tcataatcta aaatagttct gtaatatgtc tagcgctaat atattgatca taatcctgtg 48000 cataaattaa gatacaacaa tgtctcgaaa tcatcgacat ggcttcttcc atagttagaa 48060 gatcgtcgtc aaagttagca acgtgattca tcaacatttg ctgttttgag gcagcaaata 48120 ctgaaccgtc gccattcaac cattcataaa aaccatcgtc tgaatccatt gataatttct 48180 tgtactggtt tttgagagct cgcatcaatc tagcatttct agctcccgga ttgaaaacag 48240 aaagaggatc gtacatccag ggtccatttt ctgtaaatag aatcgtataa tgtcccttca 48300 agaagatatc agacgatcca caatcaaaga attggtctcc gagtttgtaa caaactgcgg 48360 actttaacct atacatgata ccgtttagca tgatttctgg tgatacgtca atcggagtat 48420 catctattag agatctaaag ccggtgtaac attctccacc aaacatattc ttattctgac 48480 gtcgttctac ataaaacatc attgctccat taacgataac aggggaatga acagcactac 48540 ccatcacatt agttcccaat ggatcaatgt gtgtaactcc agaacatctt ccatatccta 48600 tgttaggagg agcgaacacc actcttccac tattgccatc gaatgccata gaataaatat 48660 ccttggaatt gatagaaatc ggactgtcgg atgttgtgat catcttcata ggattaacaa 48720 ctatgtatgg tgccgcctga agtttcatat cgtaactgat gccgtttata ggtctagcca 48780 cagaaaccaa cgtaggtcta aatccaacta tagacaaaat agaagccaat atctgttcct 48840 catctgtcat aacttgagag catccagtat gaataatctt cattagatgg ggatctaccg 48900 catcatcatc gttacaataa aaaattccca ttctaatgtt cataattgct tttctaatca 48960 tggtatgcat gtttgctctc tgaatctctg tggaaattag atctgataca cctgtaatca 49020 ctatcggatt atcctccgta agacgattaa ccaacaacat ataattataa gactttactt 49080 ttctaaattc ataaagttgc tggattaggc tataggtgtc tccatgtaca tacgcgttc t 49140 cgagcgcagg aagtttaata ccgaatagtg ccatcagaat aggatgaata tagtaattag 49200 tttctggttt tctataaata aaagacaaat cttgtgaact agacatatcg gtaaaatgca 49260 tggattggaa tcgtgtagtc gacagaagaa tatgatgatt agatggagag tatattttat 49320 ctaactcttt gagttggtca ccgattctag gactagctcg agaatgaata agtactaaag 49380 gatgagtaca tttcacagaa acactagcat tgttcaatgt gctctttaca tgggtaagga 49440 gttgaaatag ctcgtttcta tttgttctga caatatttag tttattcata atgttaagca 49500 tatcctgaat agtaaagtta gatgtgtcat acttgttagt agttagatat ttagcaattg 49560 cattcccatc atttctcaat ctcgtactcc aatcatgtgt agatgctact tcgtcgatgg 49620 aaaccataca atcctttttg ataggctgtt gagattgatt atttcctgca cgtttaggtt 49680 tggtacgttg atttctagcc cctgcggata taaagtcatc gtctacaatt tgggacaatg 49740 aattgcatac actacaagac aaagatttat cagaagtgtg aatatgatct tcatctacca 49800 aagaaagagt ttgattagta taactagatt ttagtcctgc gttagatgtt aaaaaaacat 49860 cgctattgac cacggcttcc attatttata ttcgtagttt ttactcgaaa gcgtgatttt 49920 aatatccaat cttattactt ttggaatcgt tcaaaacctt tgactagttg t agaatttga 49980 tctattgccc tacgcgtata ctcccttgca tcatatacgt tcgtcaccag atcgtttgtt 50040 tcggcctgaa gttggtgcat atctctttca acattcgaca tgagatcctt aagggccata 50100 tcgtctagat tttgttgaga tgctgctcct ggatttggat tttgttgtgc tgttgtacat 50160 actgtaccac cagtaggtgt aggagtacat acagtggcca caataggagg ttgaggaggt 50220 gtaaccgttg gagtagtaca agaaatattt ccatccgatt gttgtgtaca tgtagttgtt 50280 ggtaacgtct gagaaggttg ggtagatggc ggtgtcgtcg tcttttgatc tttattaaat 50340 ttagagataa tatcctgaac agcattgctc ggcgtcaacg ctggaaggag tgaactcgcc 50400 ggcgcatcag tatcttcaga cagccaatca aaaagattag acatatcaga tgatgtatta 50460 gtttgttgtc gtggttttgg tgtaggaaca gtactactag gtagaagaat aggagccggt 50520 gtagctgttg gaaccggctg tggagttata tgaatagttg gttgtagcgg ttggataggc 50580 tgtctgctgg cgaccgtcat attatctcta gctagttgtt ctcgcaactg tctttgataa 50640 tacgactctt gagactttag tcctatttca atcgcttcat cctttttcgt atccggatcc 50700 ttttcttcag aataatagat tgacgacttt ggtgtagagg attctgccag cccctgtgag 50760 aacttgttaa agaagtccat ttaaggcttt aaaattgaat tgcg attata agattaaatg 50820 gcagacacag acgatattat cgactatgaa tccgatgatc tcaccgaata cgaggatgat 50880 gaagaagagg aagaagatgg agagtcacta gaaactagtg atatagatcc caaatcttct 50940 tataagattg tagaatcagc atccactcat atagaagatg cgcattccaa tcttaaacat 51000 atagggaatc atatatctgc tcttaaacga cgctatacta gacgtataag tctatttgaa 51060 atagcgggta taatagcaga aagctataac ttgcttcaac gaggaagatt acctctagtt 51120 tcagaatttt ctgacgaaac gatgaagcaa aatatgctac atgtaattat acaagagata 51180 gaggagggtt cttgtcctat agtcatcgaa aagaacggag aattgttgtc ggtaaacgat 51240 tttgacaaag atggtctaaa attccatcta gactatatta tcaaaatttg gaaacttcaa 51300 aaacgatatt agaatttata cgaatatcgt tctctaaatg tcacaatcaa gtctcgcatg 51360 ttcagcaatt tattgtcgta ctttatatcg tgttcattaa cgatatcttg caaaatagta 51420 atgattctat cttccttcga tagatattct tcagagatta ttgtcttata ttttttcttg 51480 ttatccgata tgaatttgat aagactttga acattattga tacccgtctg tttaattttt 51540 tctacagata ttttagtttt ggcagattct atcgtatctg tcaatagaca tccaacatcg 51600 acattcgacg tcaattgtct ataaatcaac gtataaa ttt tagaaataac attagcgaat 51660 tgttgtgcat tgatgtcgtt attctgaaac agtatgattt taggtagcat tttcttaaca 51720 aagagaacgt atttattgtt actcagttga acagatgata tatccagatt actaacgcat 51780 ctgattccgt ataccaaact ttcagaagaa atggtgtaca attgtttgta ttcattcaat 51840 gtctcttttt cagaaattag tttagagtcg aatactgcaa taattttcaa gagatagttt 51900 tcatcagata agattttatt tagtgtagat atgataaaac tattgttttg ttggagaact 51960 tgatacgccg cgttctctgt agtcgacgct ctcaaatggg aaacaatctc cattattttt 52020 ttggaatcgg atactatatc ttcggtatct tgacgcagtc tagtatacat agagttaaga 52080 gagattagag tttgtacatt aagcaacatg tctctaaatg tggctacaaa cttttccttt 52140 ttcacataat ctagtttatt atataccgat ttcacaacgg caccagattt aaggaaccag 52200 aatgaaaaac tctgataact acaatatttc atcatagtta cgattttatc atcttctata 52260 gttggtgtaa tagcgcatac ctttttctcc aagactggaa ccaacgtcat aaaaatgttt 52320 aaatcaaaat ccatatcaac atctgatgcg ctaagaccag tctcgcgttc aagattatct 52380 ttactaatgg tgacgaactc atcatataga actctaagtt tgtccattat ttatttacag 52440 atttagttgt ttaatttatt tgtgctcttc cagagttggg atagtatttt tctaacgtcg 52500 gtattatatt attaggatct acgttcatat gtatcataat attaatcatc cacgttttga 52560 taaatctatc tttagcttct gaaataacgt atttaaacaa aggagaaaaa tatttagcta 52620 cggcatcaga cgcaataaca ttttttgtaa atgtaacgta tttagacgac agatcttcgt 52680 taaaaagttt tccatctatg tagaatccat cggttgttaa caccattccc gcgtcagatt 52740 gaataggagt ttgaatagtt tgttttggaa atagatcctt caataactta tagttgggtg 52800 ggaaaaaatc gattttatca ctagactctt tcttttttac tatcattacc tcatgaacta 52860 tttcttgaat gagtatatgt attttctttc ctatatcgga cgcgttcatt ggaaaatata 52920 ccatgtcgtt aactataaga atatttttat cctcgtttac aaactgaata atatcagatg 52980 tagttcgtaa acgaactata tcatcaccag cacaacatct aactatatga tatccactag 53040 tttcctttag ccgtttatta tcttgttcca tattagcagt cattccatca tttaagaagg 53100 cgtcaaagat aatagggaga aatgacattt tggattctgt tacgacttta ccaaaattaa 53160 ggatatacgg acttactatc tttttctcaa cgtcgatttg atgaacacac gatgaaaatg 53220 tgcttctatg agattgatca tgtagaaaac aacaagggat acaatatttc cgcatatcat 53280 gaaatatatt aagaaatccc ac cttattat atttccccaa aggatccatg catgtaaaca 53340 ttatgccgtt atcattaata aagacttctt tctcatcgga tttgtaaaag ttgttactga 53400 tttttttcat tccaggatct agataattaa taatgatggg ttttctattc ttattctttg 53460 tattttggca tatcctagac cagtaaacag tttccacttt ggtaaaatca gcagactttt 53520 gaacgctatt aaacatggca ttaatggcaa taactaaaaa tgtaaaatat ttttctatgt 53580 taggaatatg gtttttcact ttaatagata tatggttttt ggccaaaatg atagatattt 53640 ttttatccga ggatagtaaa atattattag tcgccgtctc tataaaaatg aagctagtct 53700 cgatatccaa ttttattcta gaattgatag gagtcgccaa atgtacctta tacgttatat 53760 ctcccttgat gcgttccatt tgtgtatcta tatcggacac aagatctgta aatagtttta 53820 cgttattaat catcacggta tcgccgtcgc tagataacgc taatgtacca tccaagtccc 53880 aaatggagag atttaactgt tcatcgttta gaataaaatg attaccggtc atattaataa 53940 agtgttcatc gtatctagat aacaacgact tataattaat gtccaagtct tgaactcgct 54000 gaatgatctt ttttaaccca gttagtttta gattggtacg aaatatattg ttaaactttg 54060 attctacagt aatgtccaaa tctagttgtg gaaatacttc catcaacatt gtttcaaact 54120 tgataatatt attat ctaca tcttcatacg atccaaattc cggaatagat gtatcacatg 54180 ctcttgccac ccagataacc aaaaagtcac acgctccagg atatacattg tataaaaagc 54240 tatcgttttt tagtagtgtt tttttctgag tatatacgaa gggattaaaa atagtattat 54300 caacgtaact atattccaaa ttattcttat gagaatagat aataatatcg tccttaatat 54360 ctaacaaatt tcctaaatat ccctttaatt gagtcattcg aagcgtcaat agaatatgtc 54420 tcttaactat ttccggctgt tgtatattta aatgacttcg taaaaaataa tatatgggcg 54480 acttctcatc tatgtaatca tatggagtga gatatagggc tcgttctacc tcctgcccct 54540 tacccacctg taataccaat tgcggactta ctatatatcg catatttata tcgtggggta 54600 aagtgaaaat ctactaccga tgatgtaagt cttacaatgt tcgaaccagt accagatctt 54660 aatttggagg cctccgtaga actaggggag gtaaatatag atcaaacaac acctatgata 54720 aaggaaaata gcggttttat atcccgtagt agacgtctat tcgcccatag atctaaggat 54780 gatgagagaa aactagcact acgattcttt ttacaaagac tttatttttt agatcataga 54840 gagattcatt atttgttcag atgcgttgac gctgtaaaag acgtcactat taccaaaaaa 54900 aataacatta tcgtggcgcc ttatatagca cttttaacta tcgcatcaaa aggatgcaaa 54960 cttacagaaa caatgattga agcatttttt ccagaactat ataatgaaca tagtaagaaa 55020 tttaaattca actctcaagt atccatcatc caagaaaaac tcggatacca gtttggaaac 55080 tatcacgttt atgattttga accgtattac tctacagtag ctctggctat tcgagatgaa 55140 cattcatctg gcatttttaa tatccgtcaa gagagttatc tggtaagttc attatctga a 55200 ataacatata gattttatct aattaatcta aaatctgatc ttgttcaatg gagtgctagt 55260 acgggcgctg taattaatca aatggtaaat actgtattga ttacagtgta tgaaaagtta 55320 caactggtca tagaaaatga ttcacaattt acatgttcat tggctgtgga atcaaaactt 55380 ccaataaaat tacttaaaga tagaaatgaa ttatttacaa aattcattaa cgagttaaaa 55440 aagaccagtt cattcaagat aagcaaacgc gataaggata cgctactaaa atattttact 55500 taggactgga gttagaattt atagacgact catttcgttt atcattgtta ctattattac 55560 tattactatc attattagtg ttggcattat tagtattctt cttgtcatct tgttcagaaa 55620 tatacagcaa tgctatacct aatactaaat acattatcat gctcgcaatg gctctaacaa 55680 caacgaacca aaatgaattt ggtcgtagct tttgttcaca aaaatacata aagaaatgtc 55740 tacataaatc tatggcgcca ttggctactt gaaatagcgc cagtcctcct acagatttta 55800 atatagctgt ataacatgac atttattcat catcaaaaga gacagagtca ccatctgtca 55860 tatttagatt ttttttcatg tgttcaaagt atcctctact catttcatta taatagttta 55920 tcatacttag aattttagga cggatcaatg agtaagactt gactagatcg tcagtagtaa 55980 tttgtgcatc gtctattctg catccgcttc gtcgaataat gtatagcatc g ctttgagat 56040 tctccatagc tatcaagtct ttatacaatg acatggaaat atctgtgaat actttatact 56100 tctccaacat cgatgcctta acatcatcgc ctactttagc attgaaaata cgttctattg 56160 tgtagatgga tgtagcaaga tttttaaaca acaatgccat cttacacgat gattgcctca 56220 agtctccaat cttttgttta gaacgattag ctacagagtt caacgcttgg ctgactagca 56280 tattattatc tttagaaatt gtattcttca atgaggcgtt tatcatatct gtgatttcgt 56340 tagtcatatt acagtctgac tgggttgtaa tgttatccaa catatcacct atggatacgg 56400 tacacgtacc agcatttgta ataatcctat ctaagatgtt gtatggcatt gcgcagaaaa 56460 tatcttctcc tgtaatatct ccactctcga taaatctact cagattattc ttaaatgcct 56520 tattctctgg agaaaagata tcagtgtcca tcatttcatt aatagtatac gcagaaaaga 56580 taccacgagt atcaattcta tccaagatac ttatcggttc cgagtcacag ataatggttt 56640 cctctccttc gggagatcct gcatagaaat atctaggaca atagtttcta tactgtctgt 56700 aactctgata atctctaaag tcactaactg ataccatgaa attgagaaga tcaaacgctg 56760 aagtaatcaa tttttctgcc tcgtttttac tacaactagt tttcatcaat gtagcgacga 56820 tgtattgttt agttactctt ggtctaatac tgatgataga gata ttattg cttcccataa 56880 tggatcttct agtagtcacc ttaaagccca ttgatgcgaa tagcagatag ataaagtctt 56940 ggtatgactc ctttctaata tagtacggac tacctttgtc acccaacttt atacccacat 57000 aagccataac aacctcttta atagccgttt catgaggttt atcagccatg agcctgagta 57060 gttggaagaa tctcatgaat cccgtctcag aaagtcctat atgcatgata gatttatctt 57120 tcctgggaaa ctctcgtata gtcatagatg aaatactctt caaagtttct gaaataagat 57180 tagtaacagt cttacctccg actactctgg gtaacaaaca tactctaata ggtgttttct 57240 ctgcggagat aatatcagaa aggatagagc aataagtagt attattgtga ttataaagac 57300 cgaatacata acaggtagaa tttataaaca tcatgtcctg aaggttttta gacttgtatt 57360 cctcgtaatc cataccgtcc caaaacatgg atttggtaac tttgatagcc gtagatcttt 57420 gttccttcgc caacaggtta aagaaattaa taaagaattt gttgtttcta tttatgtcca 57480 caaattgcac gtttggaagc gccacggtta cattcactgc agcattttga ggatcgcgag 57540 tatgaagtac gatgttattg tttactggta tatctggaaa gaaatctacc agtctaggaa 57600 taagagattg atatcgcata gaaatagtaa agtttataat ctcatcatcg aagagcattt 57660 tgttaccatt gtaataaata tccactctgt catatgt ata aatgaagtac tgttcaaaca 57720 tgatgagatg tttatatgtt ggcatagtag tgagatcgac gtttggtaat ggcaatgtat 57780 taagattaac tccataatgt ctagcagcat ctgcgatgtt ataagcgtcg tcaaagcggg 57840 gtcgatcttg tattgttata tattgtctaa cacctataag attatcaaaa tcttgtctgc 57900 ttaatacacc gttaacaatt tttgccttga attcttttat tggtgcatta ataacatcct 57960 tatagaggat gttaaacaaa taagtgttat caaagttaag atctggatat ttcttttctg 58020 ctagaacatc cattgagtcg gagccatctg gtttaatata accaccgata aatctagctc 58080 tgtattctgt atccgtcaat ctaatattaa gaaggtgttg agtgaaaggt ggaagatcgt 58140 aaaagctgtg agtattaatg ataggattag tttccgaact aatgttaatt ggggtattaa 58200 taatatctat atttccagcg ttaagtgtaa cattaaacag ttttaattca cgtgacgtgg 58260 tatcaattaa ataattaatg cccaatttgg atatagcagc ctgaagctca tcttgtttag 58320 ttacggatcc taatgagtta ttaagcaata tatcgaacgg atgaacgaag gttgttttaa 58380 gttggtcaca tactttgtaa tctagacata gatgcggaag aacggtagaa actatacgaa 58440 ataaatattc agagtcctct aattgatcaa gagtaactat tgacttaata ggcatcattt 58500 atttagtatt aaatgacgac cgtaccagtg acggatatac aaaacgattt aattacagag 58560 ttttcagaag ataattatcc atctaacaaa aattatgaaa taactcttcg tcaaatgtct 58620 attctaactc acgttaacaa cgtggtagat agagaacata atgccgccgt agtgtcatct 58680 ccagaggaaa tatcctcaca acttaatgaa gatctatttc cagatgatga ttcaccggcc 58740 actattatcg aacgagtaca acctcatact actattattg acgatactcc acctcctact 58800 tttcgtagag agttattgat atcggaacaa cgtcaacaac gagaaaaaag atttaatatt 58860 acagtatcga aaaatgctga agcaataatg gaatctagat ctatgataac ttctatgcca 58920 acacaaacac catccttggg agtagtttat gataaagata aaagaattca gatgttggag 58980 gatgaagtgg ttaatcttag aaatcaacga tctaatacaa aatcatctga taatttagat 59040 aattttacca aaatactatt tggtaagact ccgtataaat caacagaagt taataagcgt 59100 atagccatcg ttaattatgc aaatttgaac gggtctccct tatcagtcga ggacttggat 59160 gtttgttcag aggatgaaat agatagaatc tataaaacga ttaaacaata tcacgaaagt 59220 agaaaacaaa aaattatcgt cactaacgtg attattattg tcataaacat tatcgagcaa 59280 gcattgctaa aactcggatt tgaagaaatc aaaggactga gtaccgatat cacttcagaa 59340 attatcgatg tggagatcgg ag atgactgc gatgctgtag catcaaaact aggaatcggt 59400 aacagtccgg ttcttaatat tgtattgttt atactcaaga tattcgttaa acgaattaaa 59460 attatttaat ttaatacatt cccatatcca gacaacaatc gtctggatta atctgttcct 59520 gtcgtctcat accggacgac atattaatct ttttattagt aggcatcttt ttagatggtt 59580 tctttttccc agcattaact gagtcgatac ctagaagatc gtgattgatc tctccgacca 59640 ttccacgaac ttctaattgg ccgtctctaa cggtaccata aactatttta ccagcattag 59700 taacagcttg gacaatctga ccatccatcg cattgtacga tgtagtagta actgttgttc 59760 tacgtctagg agcaccagaa gtatttttgg agcccttgga ggctgatgta gaagaagacg 59820 aggattttga ttttggttta catgtaatac attttgaact ctttgatttt gtatcacatg 59880 cgccggcagt cacatctgtt tgagaattaa gattattgtt gcctcctttg acggctgcat 59940 ctccaccgat ttgcgctagt agatttttaa gctgtggtgt aatcttatta actgtttcga 60000 tataatcatc gtaactgctt ctaacggcta aatttttttt atccgccatt tagaagctaa 60060 aaatattttt atttatacag aagatttaac tagattatac aatgaactaa tatgatcctt 60120 ttccagatta tttacaaact tggtattttt tggttctgga ggaggcgaat ttaaattcgg 60180 acttggattc ggatt ttgtg agttcttgat cttattatac atcgagtata ggatggcgac 60240 ggtaactgct acacaaatac cgatcaacaa aagaatacca atcatttatt gacaataact 60300 tcactattga tcaagtatgc aatatatcat cttttcacta aataagtagt aataatgatt 60360 caacaatgtc gagatatatg gacgataata atttagttca tggaaatatc gctatgattg 60420 gtatgaatga ctccgctaac tctgtggggc gcgcagtgct ttccccacat agaataaatt 60480 agcattccga ctgtgataat aataccaagt ataaacgcca taatactcaa tactttccat 60540 gtacgagtgg gactggtaga cttactaaag tcaataaagg cgaagataca cgaaagaatc 60600 aaaagaatga ttccagcgat tagcacgccg gaaaaataat ttccaatcat aagcatcatg 60660 tccatttaac taataaaaat tttaaatcgc cgaatgaaca aagtggaata taaaccatat 60720 aaaaacaata gtttgtactg caaaaataat atctattttt gttttcgaag atatggtaaa 60780 attaaatagt agtacacagc atgttataac taacagcagc aacggctcgt aattacttat 60840 catttactag acgaaaaggt ggtgggatat tttcttgctc aaataatacg aatatatcac 60900 ccatccattt tatgcgatgt ttatatactc taatctttaa tagatctata gacgacgggt 60960 ttaccaacaa tatagatttt atcgattcat ctaatttaaa cccttcctta aacgtgaatg 61020 atctatta tc tggcataacg atgaccctac ctgatgaatc ggacaatgta ctgggccatg 61080 tagaataaat tatcaacgaa ttatcgtcta cgaacattta tatcatttgt tttaatttta 61140 ggacgcgaat aaatagatat aaaatagaaa ataacagata ttacaaccag tgttatggcc 61200 gcgcccaacc aggtaggcag ttttatttta tcttttacta caggttctcc tggatgtacg 61260 tcaccaacgg cggacgtagt tctagtacaa ttagacgtaa gttccgcttg ggaatttttt 61320 aacgctaaag agttaacgtt aatcgtgcac ccaacgtatt tacatctagt tctttgaaca 61380 tcttgattat aatataacca ttttctatct ctagattcgt cggtgcactc atgtaaccaa 61440 cataccctag gtcctaaata tttatctccg gaattagatt ttggataatt cgcgcaccaa 61500 caatttctat ttcctttatg atcgttacaa aagacgtata atgccgtatc cccaaaagta 61560 aaataatcag gacgaataat tctaataaac tcagaacaat atctcgcatc catatgtttg 61620 gagcaaatat cggaataagt agacatagcc ggtttccgtt ttgcacgtaa ccattctaaa 61680 caattggggt ttccaggatc gtttctacaa aatccagtca tgaaatcgtc acaatgttct 61740 gtcttgtaat tattattaaa tatttttgga cagtgtttgg tatttgtctt agaacaacat 61800 tttgccacgc tatcactatc gcccaggaga taatcctttt ttataaaatg acatcgttgc 61860 ccggatgcta tataatcagt agcgtgtttt aaatccttaa tatattcagg agttacctcg 61920 ttctgataat agattaatga tccaggacga aatttgaaag aactacatgg ttctccatga 61980 attaatacat attgtttagc aaattcagga actataaaac tactacaatg atctatcgac 62040 ataccatcta tcaaacaaaa cttgggttta atttctcccg gagatgtttc ataatagtac 62100 gtataacttt cttctgcaaa cttaacagct ctattatatt caggataatt aaaacctaat 62160 tccatatatt tgtctcgtat atctgctatt cctggtgcta ttttgattct attaagagta 62220 acagctgccc ccattcttaa taatcgtcag tatttaaact gttaaatgtt ggtatatcaa 62280 catctacctt atttcccgca gtataaggtt tgttgcaggt atactgttca ggaatggtta 62340 catttatact tcttctatag tcctgtcttt cgatgttcat cacatatgca aagaacagaa 62400 taaacaaaat aatgtaagaa ataatattaa atatctgtga attcgtaaat acattgattg 62460 ccataataat tacagcagct acaatacaca caatagacat tcccacagtg ttgccattac 62520 ctccacgata catttgagtt actaagcaat aggtaataac taagctagta agaggcaata 62580 gaaaagatga gataaatatc atcaatatag agattagagg agggctatat agagccaaga 62640 cgaacaaaat caaaccgagt aacgttctaa catcattatt tttgaagatt cccaaataa t 62700 cattcattcc tccataatcg ttttgcatca tacctccatc tttaggcata aacgattgct 62760 gctgttcctc tgtaaataaa tctttatcaa gcactccagc acccgcagag aagtcgtcaa 62820 gcatattgta atatcttaaa taactcattt atatattaaa aaatgtcact attaaagatg 62880 gagtataatc tttatgccga actaaaaaaa atgacttgtg gtcaacccct aagtcttttt 62940 aacgaagacg gggatttcgt agaagttgaa ccgggatcat cctttaagtt tctgatacct 63000 aagggatttt acgcctctcc ttccgtaaag acgagtctag tatttgaaac attaacaacg 63060 accgataata aaatcactag tatcaatcca acaaatgcgc caaagttata tcctcttcaa 63120 cgcaaagtcg tatctgaagt agtttctaat atgaggaaaa tgatcgaatc aaaacgtcct 63180 ctatacatta ctcttcactt ggcgtgtgga tttggtaaga ctattaccac gtgttatctt 63240 atggctacac acggtagaaa aaccgtcatt tgcgtaccca ataaaatgtt aatacatcaa 63300 tggaagacac aggtagaggc agtcggattg gaacataaga tatccataga tggagtaagt 63360 agtctattaa aggaactaaa gactcaaagt ccggatgtat taatagtagt cagtagacat 63420 ctgacaaacg atgccttttg taaatatatc aataagcatt atgatttgtt catcttggat 63480 gaatcacata cgtataatct gatgaacaat acagcagtta caagattttt a gcgtattat 63540 cctccgatga tgtgttattt tttaactgct acacctagac cagctaaccg aatttattgt 63600 aacagtatta ttaatattgc caagttatcc gatctaaaaa aaactatcta tgcggtagat 63660 agtttttttg agccatattc cacagacaat attagacata tggtaaaacg actagatgga 63720 ccatctaata aatatcatat atataccgag aagttattat ctgtagacga gcctagaaat 63780 caacttattc ttaataccct ggtagaagaa ttcaagtcag gaactattaa tcgcatttta 63840 gttattacta aactacgtga acatatggta ttattctaca aacgattatt agatcttttc 63900 ggaccagagg ttgtatttat aggagacgcc caaaatagac gtactccaga tatggtcaaa 63960 tcaatcaagg aactaaatag atttatattc gtatccacct tattttattc cggtactggt 64020 ttagatattc ctagtttgga ttcgttgttc atttgctcgg cagtaatcaa caatatgcaa 64080 atagagcaat tactagggag ggtatgtcga gaaacagaac tattagatag gacggtatat 64140 gtatttccta acacatccat caaagaaata aagtacatga taggaaattt catgcaacga 64200 attattagtc tgtctgtaga taaactagga tttaaacaag aaagttatcg gaaacatcaa 64260 gaatccgatc ccacttctgt atgtacaaca tcctccagag aagaacgtgt attaaataga 64320 atatttaact cgcaaaatcg ttaagaagtt taagcgacga tccg catgct gcgcaggcca 64380 gtgtattacc cctcatagta ttaatataat ccaatgatac ttttgtgatg tcggaaatct 64440 taaccaattt agactgacag gcagaacacg tcatgcaatc atcatcgtca tcgataactg 64500 tagtcttggg cttctttttg cggctcttca ttccggaacg cacattggtg ctatccattt 64560 aggtagtaaa aaataagtca gaatatgccc tataacacga tcgtgcaaaa cctggtatat 64620 cgtctctatc tttatcacaa tatagtgtat cgacatcttt attattattg acctcgttta 64680 tcttggaaca tggaatggga acatttttgt tatcaacggc cacctttgcc ttaattccag 64740 atgttgtaaa attataacta aacagtctat catcgacaca aatgaaattc ttgtttagac 64800 gtttgtagtt tacgtatgcg gctcgttcgc gtctcatttt ttcagatatt gcaggtacta 64860 taatattaaa aataagaatg aaataacata ggattaaaaa taaagttatc atgacttcta 64920 gcgctgattt aactaactta aaagaattac ttagtctgta caaaagtttg aaattttcag 64980 attctgcggc tatagaaaag tataattctt tggtagaatg gggaacatct acttactgga 65040 aaataggcgt gcaaaaggta gctaatgtcg agacgtcaat atctgattat tatgatgagg 65100 taaaaaataa accgtttaat attgatccgg gctattacat tttcttaccg gtatattttg 65160 ggagcgtctt tatttattcg aagggtaaaa atatggt aga acttggatct ggaaactctt 65220 ttcaaatacc agatgatatg cgaagtgcgt gtaacaaagt attagacagc gataacggaa 65280 tagactttct gagatttgtt ttgttaaaca atagatggat aatggaagat gctatatcaa 65340 aatatcagtc tccagttaat atatttaaac tagctagtga gtacggatta aacataccca 65400 aatatttaga aattgaaata gaggaagaca cattatttga cgacgagtta tactctatta 65460 tagaacgctc ttttgatgat aaatttccaa aaatatccat atcgtatatt aagttgggag 65520 aacttaggcg gcaagttgta gactttttca aattctcgtt catgtatatt gagtccatca 65580 aggtagatcg tataggagat aatattttta ttcctagcgt tataacaaaa tcaggaaaaa 65640 agatattagt aaaagatgta gaccatttaa tacgatctaa ggttagagaa catacatttg 65700 taaaagtaaa aaagaaaaac acattttcca ttttatacga ctatgatggg aacggaacag 65760 aaactagagg agaagtaata aaacgaatta tagacactat aggacgagac tattatgtta 65820 acggaaagta tttctctaag gttggtagtg caggcttaaa gcaattgact aataaattag 65880 atattaatga gtgcgcaact gtcgatgagt tagttgatga gattaataaa tccggaactg 65940 taaaacgaaa aataaaaaac caatcagcat ttgatttaag cagagaatgt ttgggatatc 66000 cagaagcaga ttttataacg ttagttaata acatgcggtt caaaatagaa aattgtaagg 66060 ttgtaaattt caatattgaa aatactaatt gtttaaataa cccgagtatt gaaactatat 66120 atggaaactt taaccagttc gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat 66180 tattcgagtg aaataatatg cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt 66240 ttagaagtca aggataactc cgttagggta ttggatatat caaaattaga ctggagttct 66300 gattgggaaa ggcgcatagc taaagatttg tcacaatatg aatacactac agttcttcta 66360 gaacgtcagc ctagaaggtc gccgtatgtt aaatttatct attttattaa aggcttttta 66420 tatcatacat cggctgccaa agttatttgc gtctcgcctg tcatgtctgg taattcatat 66480 agagatcgaa aaaagagatc ggtcgaagca tttcttgatt ggatggacac attcggattg 66540 cgagactccg ttccggatag acgcaaatta gacgatgtag cggatagttt caatttggct 66600 atgagatacg tattagataa atggaatact aattatacac cttataatag gtgtaaatct 66660 agaaattaca taaaaaaaat gtaataacgt tagtaacgcc attatggata atctatttac 66720 ctttctacat gaaatagaag atagatatgc cagaactatt tttaactttc atctaataag 66780 ttgcgatgaa ataggagata tatatggtct tatgaaagaa cgcatttcct cagaggatat 66840 gtttgataat atagtatata at aaagatat acatcctgcc attaagaaac tagtgtattg 66900 cgacatccaa cttactaaac acattattaa tcagaatacg tatccggtat ttaacgattc 66960 ttcacaagtg aaatgttgtc attatttcga cataaactca gataatagca atattagctc 67020 tcgtacagta gagatatttg agagggaaaa gtcatctctt gtatcatata ttaaaactac 67080 caataagaag agaaaggtca attacggcga aataaagaaa actgttcatg gaggcactaa 67140 tgcaaattac ttttccggta aaaagtctga cgagtatctg agtactacag ttagatccaa 67200 cattaatcaa ccttggatca aaaccatttc taagagaatg agagtagata tcattaatca 67260 ctctatagta acgcgtggaa aaagctctat attacaaact atagaaatta tttttactaa 67320 tagaacatgt gtgaaaatat tcaaggattc tactatgcac attattctat ccaaggacaa 67380 ggatgaaaag gggtgtatac acatgattga caaattattc tatgtctatt ataatttatt 67440 tctgttgttc gaagatatca tccaaaacga gtactttaaa gaagtagcta atgttgtaaa 67500 ccacgtactt acggctacgg cattagatga gaaattattc ctaattaaga aaatggctga 67560 acacgatgtt tatggagtta gcaatttcaa aatagggatg tttaacctga catttattaa 67620 gtcgttggat cataccgttt tcccctctct gttagatgag gatagcaaaa taaagttttt 67680 taaggggaaa aagct caata ttgtagcatt acgatctctg gaggattgta taaattacgt 67740 gactaaatcc gagaatatga tagaaatgat gaaggaaaga tcgactattt taaatagcat 67800 agatatagaa acggaatcgg tagatcgtct aaaagaattg cttctaaaat gaaaaaaaac 67860 actgattcag aaatggatca acgactaggg tataagtttt tggtgcctga tcctaaagcc 67920 ggagtttttt atagaccgtt acatttccaa tatgtatcgt attctaattt tatattgcat 67980 cgattgcatg aaatcttgac cgtcaagcgg ccactcttat cgtttaagaa taatacagaa 68040 cgaattatga tagaaattag caatgttaaa gtgactcctc cagattactc acctataatc 68100 gcgagtatta aaggtaagag ttatgatgca ttagccacgt tcactgtaaa tatctttttt 68160 tctagacact aaataaaata tttaaaatat aatattaatg tactaaaact tatatattat 68220 taatttatct aactaaagtt agtaaattat atatataatt ttataattaa tttaatttta 68280ctaattttat ttagtgtcta gaaaaaaa 68308 <210> 18 <211> 66390 <212> DNA <213> Artificial Sequence <220> <223> sVAC fragment 2 <400> 18 tttttttcta gacactaaat aaaatattta aaatataata ttaatgtact aaaacttata 60 tattattaat ttatctaact aaagttagta aattatatat ataattttat aattaattta 120 attttactaa ttttatttag tgtctagaaa aaaaattttg ggagcgtctt tatttattcg 180 aagggtaaaa atatggtaga acttggatct ggaaactctt ttcaaatacc agatgatatg 240 cgaagtgcgt gtaacaaagt attagacagc gataacggaa tagactttct gagatttgtt 300 ttgttaaaca atagatggat aatggaagat gctatatcaa aatatcagtc tccagttaat 360 atatttaaac tagctagtga gtacggatta aacataccca aatatttaga aattgaaata 420 gaggaagaca cattatttga cgacgagtta tactctatta tagaacgctc ttttgatgat 480 aaatttccaa aaatatccat atcgtatatt aagttgggag aacttaggcg gcaagttgta 540 gactttttca aattctcgtt catgtatatt gagtccatca aggtagatcg tataggagat 600 aatattttta ttcctagcgt tataacaaaa tcaggaaaaa agatattagt aaaagatgta 660 gaccatttaa tacgatctaa ggttagagaa catacatttg taaaagtaaa aaagaaaaac 720 acattttcca ttttatacga ctatgatggg aacggaacag aaactagagg agaagtaata 780 aaacgaatta tagacactat aggacgagac tattatgtta acggaaagta tttctctaag 840 gttggtagtg c aggcttaaa gcaattgact aataaattag atattaatga gtgcgcaact 900 gtcgatgagt tagttgatga gattaataaa tccggaactg taaaacgaaa aataaaaaac 960 caatcagcat ttgatttaag cagagaatgt ttgggatatc cagaagcaga ttttataacg 1020 ttagttaata acatgcggtt caaaatagaa aattgtaagg ttgtaaattt caatattgaa 1080 aatactaatt gtttaaataa cccgagtatt gaaactatat atggaaactt taaccagttc 1140 gtctcaatct ttaatatcgt caccgatgtc aaaaaaagat tattcgagtg aaataatatg 1200 cgcctttgat ataggtgcaa aaaatcctgc cagaactgtt ttagaagtca aggataactc 1260 cgttagggta ttggatatat caaaattaga ctggagttct gattgggaaa ggcgcatagc 1320 taaagatttg tcacaatatg aatacactac agttcttcta gaacgtcagc ctagaaggtc 1380 gccgtatgtt aaatttatct attttattaa aggcttttta tatcatacat cggctgccaa 1440 agttatttgc gtctcgcctg tcatgtctgg taattcatat agagatcgaa aaaagagatc 1500 ggtcgaagca tttcttgatt ggatggacac attcggattg cgagactccg ttccggatag 1560 acgcaaatta gacgatgtag cggatagttt caatttggct atgagatacg tattagataa 1620 atggaatact aattatacac cttataatag gtgtaaatct agaaattaca taaaaaaaat 1680 gtaataacgt tagtaacgc c attatggata atctatttac ctttctacat gaaatagaag 1740 atagatatgc cagaactatt tttaactttc atctaataag ttgcgatgaa ataggagata 1800 tatatggtct tatgaaagaa cgcatttcct cagaggatat gtttgataat atagtatata 1860 ataaagatat acatcctgcc attaagaaac tagtgtattg cgacatccaa cttactaaac 1920 acattattaa tcagaatacg tatccggtat ttaacgattc ttcacaagtg aaatgttgtc 1980 attatttcga cataaactca gataatagca atattagctc tcgtacagta gagatatttg 2040 agagggaaaa gtcatctctt gtatcatata ttaaaactac caataagaag agaaaggtca 2100 attacggcga aataaagaaa actgttcatg gaggcactaa tgcaaattac ttttccggta 2160 aaaagtctga cgagtatctg agtactacag ttagatccaa cattaatcaa ccttggatca 2220 aaaccatttc taagagaatg agagtagata tcattaatca ctctatagta acgcgtggaa 2280 aaagctctat attacaaact atagaaatta tttttactaa tagaacatgt gtgaaaatat 2340 tcaaggattc tactatgcac attattctat ccaaggacaa ggatgaaaag gggtgtatac 2400 acatgattga caaattattc tatgtctatt ataatttatt tctgttgttc gaagatatca 2460 tccaaaacga gtactttaaa gaagtagcta atgttgtaaa ccacgtactt acggctacgg 2520 cattagatga gaaattattc ctaa ttaaga aaatggctga acacgatgtt tatggagtta 2580 gcaatttcaa aatagggatg tttaacctga catttattaa gtcgttggat cataccgttt 2640 tcccctctct gttagatgag gatagcaaaa taaagttttt taaggggaaa aagctcaata 2700 ttgtagcatt acgatctctg gaggattgta taaattacgt gactaaatcc gagaatatga 2760 tagaaatgat gaaggaaaga tcgactattt taaatagcat agatatagaa acggaatcgg 2820 tagatcgtct aaaagaattg cttctaaaat gaaaaaaaac actgattcag aaatggatca 2880 acgactaggg tataagtttt tggtgcctga tcctaaagcc ggagtttttt atagaccgtt 2940 acatttccaa tatgtatcgt attctaattt tatattgcat cgattgcatg aaatcttgac 3000 cgtcaagcgg ccactcttat cgtttaagaa taatacagaa cgaattatga tagaaattag 3060 caatgttaaa gtgactcctc cagattactc acctataatc gcgagtatta aaggtaagag 3120 ttatgatgca ttagccacgt tcactgtaaa tatctttaaa gaggtaatga ccaaagaggg 3180 tatatccatc actaaaataa gtagttatga gggaaaagat tctcatttga taaaaattcc 3240 gctactaata ggatacggga ataaaaatcc acttgataca gccaagtatc ttgttcctaa 3300 tgtcataggt ggagtcttta tcaataaaca atctgtcgaa aaagtaggaa ttaatctagt 3360 agaaaagatt acaacatggc caaaatttag ggttgttaag ccaaactcat tcactttctc 3420 gttttcctcc gtatcccctc ctaatgtatt accgacaaga tatcgccatt acaagatatc 3480 tctggatata tcacaattgg aagcgttgaa tatatcatcg acaaagacat ttataacggt 3540 caatattgtt ttgctgtctc aatatttatc tagagtgagt ctagaattca ttagacgtag 3600 tttatcatac gatatgcctc cagaagttgt ctatctagta aacgcgataa tagatagtgc 3660 taaacgaatt actgaatcta ttactgactt taatattgat acatacatta atgacctggt 3720 ggaagctgaa cacattaaac aaaaatctca gttaacgatc aacgagttca aatatgaaat 3780 gctgcataac tttttacctc atatgaacta tacacccgat caactaaagg gattttatat 3840 gatatcttta ctaagaaagt ttctctactg tatctaccac acttctagat atccagatag 3900 agattcgatg gtttgtcatc gcatcctaac gtacggcaaa tattttgaga cgttggcaca 3960 tgatgaatta gagaattaca taggcaacat ccgaaacgat atcatgaaca atcacaagaa 4020 cagaggcact tacgcggtaa acattcatgt actaacaact cccggactta atcacgcgtt 4080 ttctagctta ttgagtggaa agttcaaaaa gtcagacggt agttatcgaa cacatcctca 4140 ctattcatgg atgcagaata tttctattcc taggagtgtt ggattttatc cggatcaagt 4200 aaagatttca aagatgtttt ctgtcagaaa atacc atcca agtcaatatc tttacttttg 4260 ttcatcggac gttccggaaa gaggtcctca ggtaggttta gtatctcaat tgtctgtctt 4320 gagttccatt acaaatatac taacgtctga gtatttggat ttggaaaaga aaatttgtga 4380 gtatatcaga tcatattata aagatgatat aagttacttt gaaacaggat ttccaatcac 4440 tatagaaaat gctctagtcg catctcttaa tccaaatatg atatgtgatt ttgtaactga 4500 ctttagacgt agaaaacgga tgggattctt cggtaacttg gaggtaggta ttactttagt 4560 tagggatcac atgaatgaaa ttcgcattaa tattggagcg ggaagattag tcagaccatt 4620 cttggttgtg gataacggag agctcatgat ggatgtgtgt ccggagttag aaagcagatt 4680 agacgacatg acattctctg acattcagaa agagtttccg catgtcatcg aaatggtaga 4740 tatagaacaa tttactttta gtaacgtatg tgaatcggtt caaaaattta gaatgatgtc 4800 aaaggatgaa agaaagcaat acgatttatg tgactttcct gccgaattta gagatggata 4860 tgtggcatct tcattagtgg gaatcaatca caattctgga cccagagcta ttcttggatg 4920 tgctcaagct aaacaagcta tctcttgtct gagttcggat atacgaaata aaatagacaa 4980 tggaattcat ttgatgtatc cagagaggcc aatcgtgatt agtaaggctt tagaaacttc 5040 aaagattgcg gctaattgct tcggccaaca tgttactata gcattaatgt cgtacaaagg 5100 tatcaatcaa gaggatggaa ttatcatcaa aaaacaattt attcagagag gcggtctcga 5160 tatagttacc gcaaagaaac atcaagtaga aattccgttg gaaaacttta ataacaaaga 5220 aagagatagg tctaacgcct attcaaaatt agaaagtaat ggattagtta gactgaatgc 5280 tttcttggaa tccggagacg ctatggcacg aaatatctca tcaagaactc ttgaagatga 5340 ttttgctaga gataatcaga ttagcttcga tgtttccgag aaatataccg atatgtacaa 5400 atctcgcgtt gaacgagtac aagtagaact tactgacaaa gttaaggtac gagtattaac 5460 catgaaagaa agaagaccca ttctaggaga taaatttacc actagaacga gtcaaaaggg 5520 aacagtcgcg tatgtcgcgg atgaaacgga acttccatac gacgaaaatg gtatcacacc 5580 agatgtcatt attaattcta catccatctt ctctagaaaa actatatcta tgttgataga 5640 ggttatttta acagccgcat attctgctaa gccgtacaac aataagggag aaaaccgacc 5700 tgtctgtttt cctagtagta acgaaacatc catcgataca tatatgcaat tcgctaaaca 5760 atgttatgag cattcaaatc cgaaattgtc cgatgaagaa ttatcggata aaatcttttg 5820 tgaaaagatt ctctatgatc ctgaaacgga taagccttat gcatccaaag tattttttgg 5880 accaatttat tacttgcgtc tgaggcattt aactcaggac aaggca accg ttagatgtag 5940 aggtaaaaag acgaagctca ttagacaggc gaatgaggga cgaaaacgtg gaggaggtat 6000 caagttcgga gaaatggaga gagactgttt aatagcgcat ggcgcagcca atactattac 6060 agaagtttta aaagactcag aagaggatta tcaagatgtg tatgtttgtg aaaattgtgg 6120 agacatagca gcacaaatca agggtattaa tacatgtctt agatgttcaa aacttaatct 6180 ctctcctctc ttaacaaaaa ttgataccac gcacgtatct aaagtatttc ttactcaaat 6240 gaacgccaga ggcgtaaaag tcaaattaga tttcgaacga aggcctcctt cgttttataa 6300 accattagat aaagttgatc tcaagccgtc ttttctggtg taatattcta gtttggtagt 6360 agatacatat caatatcatc aaattcgaga tccgaattat aaaatgggcg tggattgtta 6420 actatagaat cggacgtctg atattcgaaa atctgtggag ttttaggttt tggtggaggt 6480 gtaactgcta cttgggatac tgaagtctga tattcagaaa gctgggggat gttctggttc 6540 gacatccacc gatggtgtca catcactaat cggttcggta acgtctgtgg atggaggtgc 6600 tacttctaca gaacctgtag cctcagttgt caacggagat acatttttaa tgcgaggaaa 6660 tgtataattt ggtaatggtt tctcatgtgg atctgaagaa gaggtaagat atctactaga 6720 aagataccga tcacgttcta gttctctttt gtagaactta actttttctt t ctcagcatc 6780 tagttgatat tccaacctct tcacgttact acgttcagat tccaattcac gttcgcatgg 6840 gttacctccg cagtttttac gagcgatttc acgttcagcc ttcatgcgtc tctccttctc 6900 tctatcgagt ttatcagagc agtctttctg aaggcgatcg aactccataa atttctccaa 6960 cgctttgatt gtttccatag atttccgaag ttcagctttt aggactgtga ttctttttct 7020 ttcgaattca cagctggatg tgcaaccgtt tccattaccg ccatctctaa gtttcttttc 7080 tagatcggca acatttcatc cccatgcctt ttacattcct cgagtctact gtcgtcgaaa 7140 tatcgttcca gctccttttc gacatcaata actttagcac gttgtctctc aagctctctt 7200 ttgtagttat ctgattccct ggcacgttta agatcttcat gcaattgagt cagctcttaa 7260 cacaatctct tgcttcttcg tcatagtact tacaatcact atgggatcca ttgttaccac 7320 gtctacactc ggcgagctcg cgtttaagag attcaatttc ccgtttgtat tggtccatgt 7380 ttccattgct accaccatta gatttacagg ctgctagttg tcgttcgaga tcagaaatac 7440 gggttttctt ggaattgatt tcgtcgatgt acttggcatc gaaacactta ttaagttctt 7500 tttccaattc tacgatttta tttctttcgc gagtcaattc cctcctgtag taactatctg 7560 ttttgtcaga ttcacgctct ctacgtagac tttcttgcaa gttactaatt tgttccc tag 7620 cacgtccgag tttagtttta tatgctgaat agagttctga ttcatccttt gagcagatct 7680 ctagcgatcg tttaagattc ctgattctag tctttagcct atttacctcc tcagaagatg 7740 ttccgttacc gttgcgttta cactcgttaa gctgtctatc aagatccatg attctatctc 7800 taagacgttg catctctctt tccatatcag cattgctttc attattacgt ctgcagtcac 7860 tcaactgtct ttcaatatct gagattctat ctctaagacg tcgcatctct ctctgtttcg 7920 gcattggttt cattattacg tctacagtcg ttcaactgtc tttcaagatc tgatattcta 7980 gattggagtc tgctaatctc tgtagcattt tcacggcatt cactcagttg tctttcaaga 8040 tctgagattt tagattggag tctgctaatc tctgtaagat ttcctcctcc gctctcgatg 8100 cagtcggtca acttattctc tagttctcta atacgcgaac gcagtgcatc aacttcttgc 8160 gtgtcttcct ggttgcgtgt acattcatcg agtctagatt cgagatctct aacgcgtcgt 8220 cgttcttcct caagttctct gcgtactaca gaaagcgtgt ccctatcttg ttgatattta 8280 gcaatttctg attctagagt actgattttg cttacgtagt tactaatagt tgtcttggcc 8340 ttatcaagat cctccttgta tttgtcgcat tccttgatat ccctacgaag tctggacagt 8400 tcccattcga cattacgacg tttatcgatt tcagctcgga gatcgtcatc gcgttgtttt 84 60 agccacatac gactgagttc aagttctcgt tgacaagatc catctacttt tccattccta 8520 atagtatcca gttccttttc tagttctgaa cgcatttctc gttccctatc aagcgattct 8580 ctcaattctc ggatagtctt cttatcaatt tctaataaat ctgaaccatc atctgtccca 8640 ttttgaatat ccctgtgttc tttgatctct tttgtaagtc ggtcgattct ttcggtttta 8700 taaacagaat ccctttccaa agtcctaatc ttactgagtt tatcactaag ttctgcattc 8760 aattcggtga gttttctctt ggcttcttcc aactctgttt taaactctcc actatttccg 8820 cattcttcct cgcatttatc taaccattca attagtttat taataactag ttggtaatca 8880 gcgattccta tagccgttct tgtaattgtg ggaacataat taggatcttc taatggattg 8940 tatggcttga tagcatcatc tttatcatta ttagggggat ggacaacctt aattggttgg 9000 tcctcatctc ctccagtagc gtgtggttct tcaataccag tgttagtaat aggcttaggc 9060 aaatgcttgt cgtacgcggg cacttcctca tccatcaagt atttataatc gggttctacg 9120 tctgaatatt cttttctaag agacgcgact tcgggagtta gtagaagaac tctgtttctg 9180 tatctatcaa cgctggaatc aatactcaag ttaaggatag cgaatacctc atcgtcatca 9240 tccgtatctt ctgaaacacc atcatatgac atttcatgaa gtctaacgta ttgataaata 9300 gaa tcagatt tagtattaaa cagatcctta acctttttag taaacgcata tgtatatttt 9360 agatctccag atttcataat atgatcacat gccttaaatg tcagtgcttc catgatataa 9420 tctggaacac taatgggtga cgaaaaagat acagcaccat atgctacgtt gataaataaa 9480 tctgaaccac taagtagata atgattaatg ttaaggaaga ggaaatattc agtatataga 9540 tatgccttag catcatatct tgtactaaac acgctaaaca gtttattgat gtgatcaatt 9600 tccaacagaa taattagagc agcgggaata ccaacaaaca tattaccaca tccgtatttt 9660 ctatgaatat cacatatcat gttaaaaaat cttgatagaa gagcgaatat ctcgtctgac 9720 ttaatgagtc gtagttcagc agcaacataa gtcataactg taaatagaac atactttcct 9780 gtagtgttga ttctagactc cacatcaaca ccattattaa aaatagtttt atatacatct 9840 ttaatctgct ctccgttaat cgtcgaacgt tctagtatac ggaaacactt tgatttctta 9900 tctgtagtta atgacttagt gatatcacga agaatattac gaattacatt tcttgttttt 9960 cttgagagac ctgattcaga actcaactca tcgttccata gtttttttac ctcagtggcg 10020 aaatctttgg agtgcttggt acatttttca ataaggttcg tgacctccat ttattataaa 10080 aaattttatt caaaacttaa ctacaatcgg gtaattataa aatcgtagat ctcccatgtg 10140 gtggaa tact accatctatc gcatgtggat ggacagtagg taatggccat gggaacagta 10200 atgtttgcat atttatcttt cttgccagta ttactgcata ttgtcccaat gtttcgatgt 10260 gatgttctaa cctatcaact gccgctgtat cacaacaata gtgtccgatg aaattaagat 10320 tatgatccaa tgtgtttaat atatgattat caagtcttat acgatccgcg tcttttttga 10380 caggatcagg ttcttctaca ggaagaagtt tcggcctctt atgatattca tgtctgggaa 10440 acggtggtct agggtgaggc tccggtatcg gagtgggttt tggattataa tcatcatcgt 10500 ctatgacatc atcttcgact tcgatattta ttttgctatc ttgatgatgt cctgtatcag 10560 ttgcattttc agcactcgac tgaatattag cgcattcatt gtctattatt accatatttc 10620 taaacccaaa atgtatgtgt tgaacatcag tactatcgtt gatgagtctt atagcatgaa 10680 ttcgcttatc gttatcgggt ttatcttctg tcaccttagc aattcctttt ttattaaact 10740 ctacataatc atatccattt ctattgtttg ttctaatata aacgagtata gcatcattgc 10800 taaatttttc aatagtatcg aaaacagaat atcctaaacc atataatata tattcaggga 10860 cactcaaact aaatgtccag gattctccta aatacgtaaa ctttaatagt gcgaaatcat 10920 tcaaaaatct accacttata gatagatagt acataaatgc gtatagtagt ctacctatct 1098 0 ctttattatg aaaaccggca ttacgatcat atatgtcgtg atatacctgt gatccgttta 11040 cgttaaacca taaatacatg ggtgatccta taaacatgaa tttatttcta attctcagag 11100 ctatagttaa ttgaccgtgt aatatttgct tacatgcata cttgatacgc tcattaataa 11160 aatttttatc attgctcgtt atctcagaat cgtatatata aggagtacca tcgtgattct 11220 taccagatat tatacaaaat actatatata aaatatattg accaacgtta gtaatcatat 11280 aaatgtttaa cgttttaaat tttgtattca atgatccatt atcatacgct agcatggtct 11340 tatgatattc attctttaaa atataatatt gtgttagcca ttgcattggg gctcctaatg 11400 gagatttttt attctcatcc attttaggat aggctttcat aaagtcccta ataacttcgt 11460 gaataatgtt tctatgtttt ctactgatgc atgtatttgc ttcgattttt ttatcccatg 11520 tttcatctat catagattta aacgcagtaa tgctcgcaac attaacatct tgaaccgttg 11580 gtacaattcc gttccataaa tttataatgt tcgccattta tataactcat tttttgaata 11640 tacttttaat taacaaaaga gttaagttac tcatatgggc gccgtccagt ctgaacatca 11700 atctttttag ccagagatat catagccgct cttagagttt cagcgtgatt ttccaaccta 11760 aatagaactt catcgttgcg tttacaacac ttttctattt gttcaaactt tgttgtt aca 11820 ttagtaatct ttttttccaa attagttagc cgttgtttga gagtttcctc attgtcgtct 11880 tcatcggctt taacaattgc ttcgcgttta gcctctggct ttttagcagc ctttgtagaa 11940 aaaaattcag ttgctggaat tgcaagatcg tcatctccgg ggaaaagagt tccgtccatt 12000 taaagtacag attttagaaa ctgacactct gcgttattta tatttggtac aacacatgga 12060 ttataaatat cgatgttaat aacatcagaa aatgtaaagt ctatacattg ttgcatcgtg 12120 ttaaattttc taatggatct agtattattg ggtccaactt ctgcctgaaa tccaaatatg 12180 gaagcggata caaaaccgtt tcctggataa accacacatc tccacttttg ctttacatca 12240 gaaattgtgt cgttgacatc ttgaactctc ctatctaatg ccggtgttcc acctatagat 12300 tttgaatatt cgaatgctgc atgagtagca ttaaattcct taatattgcc ataattttca 12360 tatattgagt aaccctggat aaaaagtaaa cacaccgcag ccgtcgctac cacaataaaa 12420 aaaattgata gagagttcat ttataatcta ttagaagctg acaaaatttt tttacacgca 12480 tcagacaatg ctttaataaa tagttcaaca tctacttttg tcatatcgaa ccgatggtat 12540 gattctaacc tagaattaca tccgaaaaag ttgactatgt tcatagtcat taagtcatta 12600 acaaacaaca ttccagactc tggattataa gacgatactg tttcgtcaca attacctacc 12660 ttaatcatgt gattatgaat attggctatt agagcacctt ctaagaaatc tataatatct 12720 ttgaaacacg atttaaaatc aaaccacgaa tatacttcta cgaagaaagt tagtttaccc 12780 ataggagaaa taactataaa tggagatcta aatacaaaat ccggatctat gatagtttta 12840 acattattat attctctatt aaatacctcc acatctaaaa atgttaattt tgaaactatg 12900 tcttcgttta ttaccgtacc tgaactaaac gctataagct ctattgtttg agaactcttt 12960 aaacgatatt cttgaaatac atgtaacaaa gtttccttta actcggtcgg tttatctacc 13020 atagttacag aatttgtatc cttatctata atataataat caaaatcgta taaagttata 13080 taattatcgc gttcagattg ggatcttttc aaatagacta aaaaccccat ttctctagta 13140 agtatcttat gtatatgttt gtaaaatatc ttcatggtgg gaatatgctc taccgcagtt 13200 agccattcct cattgacagc ggtagatgta ttagacaaaa ctattccaat gtttaacaag 13260 ggccatttta cgagattatt aaatccttgt ttgataaatg tagccaatga gggttcgagt 13320 tcaacgacga ttgaattctc ttcccgcgga tgctgcatga tgaacgacgg gatgttgttc 13380 gattgatttg gaattctttt tcgacttttt gtttatatta aatattttaa aatttatagc 13440 ggatagcaat tcatgtacca cggataatgt agacgcgtat tg cgcatcga tatctttatt 13500 attagataaa tttatcaata aatgtgagaa gtttgcctcg ttaaggtctt ccatttaaat 13560 attatataaa catttgtgtt tgtatcttat tcgtctttttaacta tggaatagtttttaacta ttttactagttttagtaacta 13620 cgttccaaaa agtcgacggc ggacattttt aacatggcat ctattttaaa tacacttagg 13740 tttttggaaa aaacatcatt ttataattgt aacgattcaa taactaaaga aaagattaag 13800 attaaacata agggaatgtc atttgtattt tataagccaa agcattctac cgttgttaaa 13860 tacttgtctg gaggaggtat atatcatgat gatttggttg tattggggaa ggtaacaatt 13920 aataatctaa agatgatgct attttacatg gatttatcat atcatggagt gacaagtagt 13980 ggagcaattt acaaattggg atcgtctatc gatagacttt ctctaaatag gactattgtt 14040 acaaaagtta ataattatga tgatacattt tttgacgacg atgattgatc gctattgcac 14100 aattttgttt ttttactttc taatatagcg tttagattct ttttcatgtg cgaatattga 14160 tttactaaaa tatcgatgtt taacttttgt tctatgacgt ccttatcagc ggtatcggta 14220 catatacgta attcaccttc acaaaatacg gagtcttcga taataatagc caatcgatta 14280 ttggatctag ctgtctgtat catattcaac atgtttaata tatcctttcg tttccccttt 14340 acaggcatcg atcgtagcat attttccgcg tctgagatgg aaatgttaaa actacaaaaa 14400 tgcgtaatgt tagcccgtcc taatattggt acgtgtctat aagtttggca tagtagaata 14460 atagacgtgt ttaaatgcct tccaaagttt aagaattcta ttagagtatt gcattttga t 14520 agtttatcac ctacatcatc aaaaataagt aaaaagtgtg ctgatttttt atgattttgt 14580 gcgacagcaa tacatttttc tatgttactt ttagttcgta tcagattata ttctagagat 14640 tcctgactac taacgaaatt aatatgattt ggccaaatgt atccatcata atctgggtta 14700 taaacgggtg taaacaagaa tatatgttta tattttttaa ctagtgtaga aaacagagat 14760 agtaaataga tagtttttcc agatccagat cctcccgtta aaaccattct aaacggcatt 14820 tttaataaat tttctcttga aaattgtttt tcttggaaac aattcataat tatatttaca 14880 gttactaaat taatttgata ataaatcaaa atatggaaaa ctaaggtcgt tagtagggag 14940 gagaacaaag aaggcacatc gtgacataaa taacatttat tatcatgatg acaccagaaa 15000 acgacgaaga gcagacatct gtgttctccg ctactgttta cggagacaaa attcaaggaa 15060 agaataaacg caaacgcgtg attggtctat gtattagaat atctatggtt atttcactac 15120 tatctatgat taccatgtcc gcgtttctca tagtgcgcct aaatcaatgc atgtctgcta 15180 acgaggctgc tattactgac gccgctgttg ccgttgctgc tgcatcatct actcatagaa 15240 aggttgcgtc tagcactaca caatatgatc acaaagaaag ctgtaatggt ttatattacc 15300 agggttcttg ttatatatta cattcagact accagttatt ctcggatgct a aagcaaatt 15360 gcactgcgga atcatcaaca ctacccaata aatccgatgt cttgattacc tggctcattg 15420 attatgttga ggatacatgg ggatctgatg gtaatccaat tacaaaaact acatccgatt 15480 atcaagattc tgatgtatca caagaagtta gaaagtattt ttgtgttaaa acaatgaact 15540 aatatttatt tttgtacatt aataaatgaa atcgcttaat agacaaactg taagtaggtt 15600 taagaagttg tcggtgccgg ccgctataat gatgatactc tcaaccatta ttagtggcat 15660 aggaacattt ctgcattaca aagaagaact gatgcctagt gcttgcgcca atggatggat 15720 acaatacgat aaacattgtt atttagatac taacattaaa atgtctacag ataatgcggt 15780 ttatcagtgt cgtaaattac gagccagatt gcctagaccg gatactagac atctgagagt 15840 attgtttagt attttttata aagattattg ggtaagttta aaaaagacca atgataaatg 15900 gttagatatt aataatgata aagatataga tattagtaaa ttaacaaatt ttaaacaact 15960 aaacagtacg acggatgctg aagcgtgtta tatatacaag tctggaaaac tggttaaaac 16020 agtatgtaaa agtactcaat ctgtactatg tgttaaaaaa ttctacaagt gacaacaaaa 16080 aatgaattaa taataagtcg ttaacgtacg ccgccatgga cgccgcgttt gttattactc 16140 caatgggtgt gttgactata acagatacat tgtatgatga tctc gatatc tcaatcatgg 16200 actttatagg accatacatt ataggtaaca taaaaactgt ccaaatagat gtacgggata 16260 taaaatattc cgacatgcaa aaatgctact ttagctataa gggtaaaata gttcctcagg 16320 attctaatga tttggctaga ttcaacattt atagcatttg tgccgcatac agatcaaaaa 16380 ataccatcat catagcatgc gactatgata tcatgttaga tatagaagat aaacatcagc 16440 cattttatct attcccatct attgatgttt ttaacgctac aatcatagaa gcgtataacc 16500 tgtatacagc tggagattat catctaatca tcaatccttc agataatctg aaaatgaaat 16560 tgttgtttaa ttcttcattc tgcatatcag acggcaatgg atggatcata attgatggga 16620 aatgcaatag taatttttta tcataaaagt tgtaaagtaa ataataaaac aataaatatt 16680 gaactagtag tacgtatatt gagcaatcag aaatgatgct ggtacctctt atcacggtga 16740 ccgtagttgc gggaacaata ttagtatgtt atatattata tatttgtagg aaaaagatac 16800 gtactgtcta taatgacaat aaaattatca tgacaaaatt aaaaaagata aagagttcta 16860 attccagcaa atctagtaaa tcaactgata gcgaatcaga ctgggaggat cactgtagtg 16920 ctatggaaca aaacaatgac gtagataata tttctaggaa tgagatattg gacgatgata 16980 gcttcgctgg tagtttaata tgggataacg aatccaa tgt catggcgcct agcacagaac 17040 acatttacga tagtgttgct ggaagcacgc tgctaataaa taatgatcgt aatgaacaga 17100 ctatttatca gaacactaca gtagtaatta atgagacgga gactgttgaa gtacttaatg 17160 aagataccaa acagaatcct aactattcat ccaatccttt cgtaaattat aataaaacca 17220 gtatttgtag caagtcaaat ccgttcatta cagaactcaa caataaattt agtgagaata 17280 atccgtttag acgagcacat agcgatgatt atcttaataa gcaagaacaa gatcatgaac 17340 acgatgatat agaatcatcg gtcgtatcat tggtgtgatt agtttccttt ttataaaatt 17400 gaagtaatat ttagtattat tgctgccgtc acgttgtaca aatggagata ttccctgtat 17460 tcggcatttc taaaattagc aattttattg ctaataatga ctgtagatat tatatagata 17520 cagaacatca aaaaattata tctgatgaga tcaatagaca gatggatgaa acggtacttc 17580 ttaccaacat cttaagcgta gaagttgtaa atgacaatga gatgtaccat cttattcccc 17640 atagactatc gactattata ctctgtatta gttctgtcgg aggatgtgtt atctctatag 17700 ataatgacat caatgacaaa aatattctaa catttcccat tgatcatgct gtaatcatat 17760 ccccactgag taaatgtgtc gtagttagca agggtcctac aaccatattg gttgttaaag 17820 cggatatacc cagcaaacga ttggtaacat cgtttacaaa cgacatactg tatgtaaaca 17880 atctgtcact gattaattat ttgccgttgt ctgtattcat tattagacga gtcaccgact 17940 atttggatag acacatatgc gatcagatat ttgcgaataa taagtggtat tccattataa 18000 ccatcgacga taagcaatat cctattccat caaactgtat aggtatgtcc tctgccaagt 18060 acataaattc tagcatcgag caagatactt taatacatgt ttgtaacctc gagcatccat 18120 tcgacttagt atacaaaaaa atgcagtcgt acaattctgt acctatcaag gaacaaatat 18180 tgtacggtag aattgataat ataaatatga gcattagtat ttctgtggat taatagattt 18240 ctagtatggg gatcattaat catctctaat ctctaaatac ctcataaaac gaaaaaaaag 18300 ctattatcaa atactgtacg gaatggattc attctcttct ctttttatga aactctgttg 18360 tatatctact gataaaactg gaagcaaaaa atctgataaa aagaataaga ataagatcaa 18420 ggattatatg gaacacgatt attataaaat aacaatagtt cctggttcct cttccacgtc 18480 tactagctcg tggtattata cacatgccta gtaatagtct ctttgcgttg acggaaagca 18540 gactagaaat aacaggctaa aatgttcaga caccataata gttcccaacc cagataataa 18600 cagagtacca tcaacacatt cctttaaact caatcccaaa cccaaaaccg ttaaaatgta 18660 tccggccaat tgatagtaga ta atgaggtg tacagcgcat gataatttac acagtaacca 18720 aaatgaaaat actttagtaa ttataagaaa tatagatggt aacgtcatca tcaacaatcc 18780 aataatatgc cggagagtaa acattgacgg ataaaacaaa aatgctccgc ataactctat 18840 catggcaata acacaaccaa atacttgtaa gattcctaaa ttagtagaaa atacaacgga 18900 tatcgatgta taagtgatct cgagaaataa taagaataaa gtaatgcccg taaagataaa 18960 catcaacatt gtttggtaat cattaaacca attagtatga agttgaacta atttcacagt 19020 agattttatt ccagtgttat cctcgcatgt atacgtacct ggtaagatat ctttatattc 19080 tataatcaat gagacatcac tatccgataa cgaatgaagt ctagcactag tatgccattt 19140 acttaatatg gtcgtcttgg aagttttatt ataagttaaa atatcatggt tgtccaattt 19200 ccatctaata tactttgtcg gattatctat agtacacgga ataatgatgg tattattaca 19260 tgctgtatac tctatagtct ttgtagatgt tataatcata aaagtacaga ggtatatcaa 19320 cgatattcta actcttgaca ttttttattt atttaaaatg atacctttgt tatttatttt 19380 attctatttt gctaacggta tcgaatggca taagtttgaa acgagtgaag aaataatttc 19440 tacttactta ttagacgacg tattatacac gggtgttaat ggggcggtat acacattttc 19500 aaataataaa ctaaa caaaa ctggtttagc taatactaat tatatcacaa catctataaa 19560 agtagaggat gcggataagg atacattagt atgcggaacc aataacggaa atcccaaatg 19620 ttggaaaata gacggttcag acgacccaaa acatagaggt agaggatacg ctccttatca 19680 aaatagcaaa gtaacgataa tcagtcacaa cggatgtgta ctatctgaca taaacatatc 19740 aaaagaagga attaaacgat ggagaagatt tgacggacca tgtggttatg atttatacac 19800 ggcggataac gtaattccaa aagatggttt acgaggagca ttcgtcgata aagatggtac 19860 ttatgacaaa gtttacattc ttttcactga tactatcggc tcaaagagaa ttgtcaaaat 19920 tccgtatata gcacaaatgt gcctaaacga cgaaggtggt ccatcatcat tgtctagtca 19980 tagatggtcg acgtttctca aagtcgaatt agaatgtgat atcgacggaa gaagttatag 20040 acaaattatt cattctagaa ctataaaaac agataatgat acgatactat atgtattctt 20100 cgatagtccg cattatgtac ctattctatg aataccatta aacaatcttt ttctacgtca 20160 aaattggaag gatatacaaa gcaattgccg tctccagctc ctggtatatg tctaccagct 20220 ggaaaagttg ttccacatac cacgtttgaa gtcatagaaa aatataatgt actagatgat 20280 attataaagc ctttatctaa ccaacctatc ttcgaaggac cgtctggtgt taaatggttc 20340 gatataaa gg agaaggaaaa tgaacatcgg gaatatagaa tatacttcat aaaagaaaat 20400 tctatatatt cgttcgatac aaaatctaaa caaactcgta gctcgcaagt cgatgcgcga 20460 ctattttcag taatggtaac ttcgaaaccg ttatttatag cagatatagg gataggagta 20520 ggaatgccac aaatgaaaaa aatacttaaa atgtaatctt aatcgagtac accacacgac 20580 aatgaacaaa cataagacag attatgctgg ttatgcttgc tgcgtaatat gcggtctaat 20640 tgttggaatt atttttacag cgacactatt aaaagttgta gaacgtaaat tagttcatac 20700 accatcaata gataaaacga taaaagatgc atatattaga gaagattgtc ctactgactg 20760 gataagctat aataataaat gtatccattt atctactgat cgaaaaacct gggaggaagg 20820 acgtaatgca tgcaaagctc taaatccaaa ttcggatcta attaagatag agactccaaa 20880 cgagttaagt tttttaagaa gcattagacg cggatattgg gtaggagaat ccgaaatatt 20940 aaaccagaca accccatata attttatagc taagaatgcc acgaagaatg gaactaaaaa 21000 acggaaatat atttgtagca caacgaatac tcccaaactg cattcgtgtt acactatata 21060 acaattacac tacattttta tcataccact acttcggtta gatgttttag aaaaaaataa 21120 atatcgccgt accgttcttg tttttataaa aataacaatt aacaattatc aaattttttc 21180 tttaatattt tacgtggttg accattcttg gtggtaaaat aatctcttag tgttggaatg 21240 gaatgctgtt taatgtttcc acactcatcg tatattttga cgtatgtagt cacatcgttt 21300 acgcaatagt cagactgtag ttctatcatg cttcctacat tagaaggagg aacagtttta 21360 aagtctcttg gttttaatct attaccgtta gttttcatga aatcctttgt tttatccact 21420 tcacatttta aataaatgtc cactatacat tcttctgtta attttactag atcgtcatgg 21480 gtcatagaat ttataggttc cgtagtccat ggatccaaac tagcaaactt cgcgtatacg 21540 gtatcgcgat tagtgtatac accaactgta tgaaaattaa gaaaacagtt taatagatca 21600 acagaaatat ttaatcctcc gtttgataca gatgcaccat atttatggat tttggattca 21660 cacgttgttt gtctgagggg ttcgtctagc gttgcttcta cataaacttc tattcccata 21720 tattctttat tgtcagaatc gcataccgat ttatcatcat acactgtttg aaaactaaat 21780 ggtatacaca tcaaaataac aaatactaac gagtacattc tgcaatattg ttatcgtaat 21840 tggaaaaata gtgttcgagt gagttggatt atgtgagtat tggattgtat attttatttt 21900 atattttgta ataagaataa aatgctaatg tcaagtttat tccaatagat gtcttattaa 21960 aaacatatat aataaataac aatggctgaa tggcataaaa ttatcgagga tatctcaaa a 22020 aataataagt tcgaggatgc cgccatcgtt gattacaaga ctacaaagaa tgttctagct 22080 gctattccta acagaacatt tgccaagatt aatccgggtg aaattattcc tctcatcact 22140 aatcgtaata ttctaaaacc tcttattggt cagaaatatt gtattgtata tactaactct 22200 ctaatggatg agaacacgta tgctatggag ttgcttactg ggtacgcccc tgtatctccg 22260 atcgttatag cgagaactca taccgcactt atatttttga tgggtaagcc aacaacatcc 22320 agacgtgacg tgtatagaac gtgtagagat cacgctaccc gtgtacgcgc aactggtaat 22380 taaaataaaa agtaatattc atatgtagtg tcaattttaa atgatgatga tgaaatggat 22440 aatatccata ttgacgatgt caataatgcc ggtattggca tacagctcat cgatttttag 22500 atttcattca gaggatgtgg aattatgtta tgggcatttg tattttgata ggatctataa 22560 tgtagtaaat ataaaatata atccgcatat tccatataga tataatttta ttaatcgcac 22620 gttaaccgta gatgaactag acgataatgt cttttttaca catggttatt ttttaaaaca 22680 caaatatggt tcacttaatc ctagtttgat tgtctcatta tcaggaaact taaaatataa 22740 tgatatacaa tgctcagtaa atgtatcgtg tctcattaaa aatttggcaa cgagtacatc 22800 tactatatta acatctaaac ataagactta ttctctacat cggtccacgt g tattactat 22860 aataggatac gattctatta tatggtataa agatataaat gacaagtata atggcatcta 22920 tgattttact gcaatatgta tgctaatagc gtctacattg atagtgacca tatacgtgtt 22980 taaaaaaata aaaatgaact cttaattatg ctatgctatt agaaatggat aaaatcaaaa 23040 ttacggttga ttcaaaaatt ggtaatgttg ttaccatatc gtataacttg gaaaagataa 23100 ctattgatgt cacacctaaa aagaaaaaag aaaaggatgt attattagcg caatcagttg 23160 ctgtcgaaga ggcaaaagat gtcaaggtag aagaaaaaaa tattatcgat attgaagatg 23220 acgatgatat ggatgtagaa agcgcataat acgatctata aaaataagta tataaatact 23280 ttttatttac tgtactctta ctgtgtagtg gtgataccct actcgattat ttttttaaaa 23340 aaatacttat tctgattctt ctagccattt ccgtgttcgt tcgaatgcca catcgacgtt 23400 aaagataggg gagtagttga aatctagttc tgcattgttg gtacgcacct caaatgtagt 23460 gttggatatc ttcaacgtat agttgttgag tagtgatggt tttctaaata gaattctctt 23520 catatcattc ttgcacgcgt acatttttag catccatctt ggaattctag atccttgttc 23580 tattcccaat ggtttcatca atagaagatt aaacatatcg tacgaacacg atggagagta 23640 atcgtagcaa aagtaagcat ttcctttaat ctcagatccc ggat actgga tatattttgc 23700 agccaacacg tgcatccatg caacatttcc tacatatacc cggctatgca ccgcgtcatc 23760 atcgactgta cgatacataa tgttaccgtg ttgcttacat tgctcgtaaa agactttcgt 23820 caatttgtct ccttctccgt aaattccagt gggtcttagg caacaagtat acaattttgc 23880 tccattcatg attacggaat tattggcttt cataaccagt tgctcggcca tacgtttact 23940 ttttgcgtat acatgtcctg gtgatatatc ataaagggta tgctcatggc cgatgaatgg 24000 atcaccgtgt ttatttggtc ctattgcttc catgctacta gtatagatca aatacttgat 24060 tcctaggtcc acacaagctg ccaatatagt ctgtgttcca taatagttta ctttcatgat 24120 ttcattatcg gtgtattttc caaatacatc cactagagca gccgtatgaa taatcagatt 24180 taccccatct agcgcttctc tcaccttatc aaagtcgttt atatcacatt gtatatagtt 24240 tataacctta actttcgagg ttattggttg tggatcttct acaatatcta tgactctgat 24300 ttcttgaaca tcatctgcac taattaacag ttttactata tacctgccta gaaatccggc 24360 accaccagta accgcgtaca cggccattgc tgccactcat aatatcagac tacttattct 24420 attttactaa ataatggctg tttgtataat agaccacgat aatatcagag gagttattta 24480 ctttgaacca gtccatggaa aagataaagt tttagga tca gttattggat taaaatccgg 24540 aacgtatagt ttgataattc atcgttacgg agatattagt caaggatgtg attccatagg 24600 cagtccagaa atatttatcg gtaacatctt tgtaaacaga tatggtgtag catatgttta 24660 tttagataca gatgtaaata tatctacaat tattggaaag gcgttatcta tttcaaaaaa 24720 tgatcagaga ttagcgtgtg gagttattgg tatttcttac ataaatgaaa agataataca 24780 ttttcttaca attaacgaga atggcgtttg atatatcagt taatgcgtct aaaacaataa 24840 atgcattagt ttacttttct actcagcaaa ataaattagt catacgtaat gaagttaatg 24900 atacacacta cactgtcgaa tttgataggg acaaagtagt tgacacgttt atttcatata 24960 atagacataa tgacaccata gagataagag gggtgcttcc agaggaaact aatattggtt 25020 gcgcggttaa tacgccggtt agtatgactt acttgtataa taagtatagt tttaaactga 25080 ttttagcaga atatataaga cacagaaata ctatatccgg caatatttat tcggcattga 25140 tgacactaga tgatttggct attaaacagt atggagacat tgatctatta tttaatgaga 25200 aacttaaagt agactccgat tcgggactat ttgactttgt caactttgta aaggatatga 25260 tatgttgtga ttctagaata gtagtagctc tatctagtct agtatctaaa cattgggaat 25320 tgacaaataa aaagtatagg tgtatggcat tagccgaaca tatatctgat agtattccaa 25380 tatctgagct atctagacta cgatacaatc tatgtaagta tctacgcgga cacactgaga 25440 gcatagagga taaatttgat tattttgaag acgatgattc gtctacatgt tctgccgtaa 25500 ccgacaggga aacggatgta taattttttt tatagcgtga aggatatgat aaaaaatata 25560 attgttgtat ttatcccatt ccaatcacct tatatgattc tgtaacacaa tgaaggagtc 25620 tcatagatgt atagaggtca gatactggtt tgataaactg tttattccac atgagtatgt 25680 ttgactttat ggttagaccc gcatacttta acaaatcact gaaaattgga gttaggtatt 25740 gacctctcag aatcagttgc cgttctggaa cattaaatgt attttttatg atatactcca 25800 acgcatttat gtgggcatac aacaagtcat tactaatgga gtattccaag agttttagtt 25860 gtctagtatt taacaagaga agagatttca acagactgtt tatgaactcg aatgccgcct 25920 cattgtcgct tatattgatg atgtcgaatt ctcccaatat catcaccgat gagtagctca 25980 tcttgttatc gggatccaag ttttctaaag atgtcattaa accctcgatc atgaatggat 26040 ttatcatcat cgtttttatg ttggacatga gcttagtccg tttgtccaca tctatagacg 26100 acgatttctg aattatttta tatatccctc tctttaactc caggaacttg tcaggatggt 26160 ctactttaat atgttctcgt ct aagagatg aaaatctttg gatggttgca cgcgactttt 26220 ctctaaagga tgacgttgcc caagatcctc tcttaaatga atccatctta tccttggaca 26280 agatggacag tctattttcc ttagatggtt taatattttt gttacccatg atctataaag 26340 gtagacctaa tcgtctcgga tgacctatat atttattttc agttttatta tacgcataaa 26400 ttgtaaaaaa tatgttaggt ttacaaaaat gtctcgtggg gcattaatcg tttttgaagg 26460 attggacaaa tctggaaaaa caacacaatg tatgaacatc atggaatcta taccggcaaa 26520 cacgataaaa tatcttaact ttcctcagag atccactgtc actggaaaga tgatagatga 26580 ctatctaact cgtaaaaaaa cctataatga tcatatagtt aatctattat tttgtgcaaa 26640 tagatgggag tttgcatctt ttatacaaga acaactagaa cagggaatta ctttaatagt 26700 tgatagatac gcgttctctg gagtagcgta tgccgccgct aaaggcgcgt caatgactct 26760 cagtaagagt tatgaatctg gattgcctaa acccgactta gttatattct tggaatctgg 26820 tagcaaagaa attaatagaa acgtcggcga ggaaatttat gaagatgtta cattccaaca 26880 aaaggtatta caagaatata aaaaaatgat tgaagaagga gatattcatt ggcaaattat 26940 ttcttctgaa ttcgaggaag atgtaaagaa ggagttgatt aagaatatag ttatagaggc 27000 tatacacacg gttac tggac cagtggggca actgtggatg taatagtgaa attacatttt 27060 ttataaatag atgttagtac agtgttataa atggatgaag catattactc tggcaacttg 27120 gaatcagtac tcggatacgt tatta ctatatg tatta tatta tatta tatta tatta tatta tatta tatta tatta tatta tatta tatta tatta atcatgtgta gatcaaactt ggataatcca tttatctctt tcctagatac tgtatatact 27300 attatagatc aagagaacta tcagaccgaa ttgattaatt cattagacga caatgaaatt 27360 atcgattgta tagttaataa gtttatgagc ttttataagg ataacctaga aaatatagta 27420 gatgctatca ttactctaaa atatataatg aataatccag attttaaaac tacgtatgcc 27480 gaagtactcg gttccagaat agccgatata gatattaaac aagtgatacg tgagaatata 27540 ctacaattgt ctaatgatat ccgcgaacga tatttgtgaa aaatattaaa aaaaaatact 27600 ttttttatta aatgacgtcg cttcgcgaat ttagaaaatt atgctgtgat atatatcacg 27660 catcaggata taaagaaaaa tctaaattaa ttagagactt tataacagat agggatgata 27720 aatatttgat cattaagcta ttgcttcccg gattagacga tagaatttat aacatgaacg 27780 ataaacaaat tataaaatta tatagtataa tatttaaaca atctcaggaa gatatgctac 27840 aagatttagg atacggatat ataggagaca ctattaggac tttcttcaaa gagaacacag 27900 aaatccgtcc acgagataaa agcattttaa ctttagaaga cgtggatagt ttcttaacta 27960 cgttatcatc cgtaactaaa gaatcgcatc aaataaaatt attgactgat atcgcatccg 28020 tttgtacatg taatgattta aaatgtgtag tcatgcttat tgataaagat ctaaaaatt a 28080 aagcgggtcc tcggtacgta cttaacgcta ttagtcctaa tgcctatgat gtgtttagaa 28140 aatctaataa cttgaaagag ataatagaaa atgcatctaa acaaaatcta gactctatat 28200 ctatttctgt tatgactcca attaatccca tgttagcgga atcgtgtgat tctgtcaata 28260 aggcgtttaa aaaatttcca tcaggaatgt ttgcggaagt caaatacgat ggtgaaagag 28320 tacaagttca taaaaataat aacgagtttg ccttctttag tagaaacatg aaaccagtac 28380 tctctcataa agtggattat ctcaaagaat acataccgaa agcatttaaa aaagctacgt 28440 ctatcgtatt ggattctgaa attgttcttg tagacgaaca taatgtaccg ctcccgtttg 28500 gaagtttagg aatacacaaa aagaaagaat ataaaaactc taacatgtgt ttgttcgtgt 28560 ttgactgttt gtactttgat ggattcgata tgacggacat tccattgtac gaacgaagat 28620 cttttctcaa agatgttatg gttgaaatac ccaatagaat agtattctca gagttgacga 28680 atattagtaa cgagtctcag ttaactgacg tattggatga tgcactaacg agaaaattag 28740 aaggattggt cttaaaagat attaatggag tatacgaacc gggaaagaga agatggttaa 28800 aaataaagcg agactatttg aacgagggtt ccatggcaga ttctgccgat ttagtagtac 28860 taggtgctta ctatggtaaa ggagcaaagg gtggtatcat ggcagtcttt c taatgggtt 28920 gttacgacga tgaatccggt aaatggaaga cggttaccaa gtgttcagga cacgatgata 28980 atacgttaag ggttttgcaa gaccaattaa cgatggttaa aattaacaag gatcccaaaa 29040 aaattccaga gtggttggta gttaataaaa tctatattcc cgattttgta gtagaggatc 29100 cgaaacaatc tcagatatgg gaaatttcag gagcagagtt tacatcttcc aagtcccata 29160 ccgcaaatgg aatatccatt agatttccta gatttactag gattagagaa gataaaacgt 29220 ggaaagaatc tactcatcta aacgatttag taaacttgac taaatcttaa tagttacata 29280 caaactgaaa attaaaataa cactatttag ttggtggtcg ccatggatgg tgttattgta 29340 tactgtctaa acgcgttagt aaaacatggc gaggaaataa atcatataaa aaatgatttc 29400 atgattaaac catgttgtga aagagtttgt gaaaaagtca agaacgttca cattggcgga 29460 caatctaaaa acaatacagt gattgcagat ttgccatata tggataatgc ggtatccgat 29520 gtatgcaatt cactgtataa aaagaatgta tcaagaatat ccagatttgc taatttgata 29580 aagatagatg acgatgacaa gactcctact ggtgtatata attattttaa acctaaagat 29640 gttattcctg ttatcatatc tataggaaag gataaagatg tctgtgaact attaatctca 29700 tcagacatat cgtgtgcatg cgtggagtta aattcatatc acgt agccat tcttcccatg 29760 gatgtttcct tttttaccaa aggaaatgca tcattgatta ttctcctgtt tgatttctct 29820 atcgatgcag cacctctctt aagaagtgta accgataata atgttattat atctagacac 29880 cagcgtctac atgacgagct tccgagttcc aattggttca agttttacat aagtataaag 29940 tccgactatt gttctatatt atatatggtt gttgatggat ctgtgatgca tgcgatagct 30000 gataatagaa ctcacgcaat tattagcaaa aatatattag acaatactac gattaacgat 30060 gagtgtagat gctgttattt tgaaccacag attaggattc ttgatagaga tgagatgctc 30120 aatggatcat cgtgtgatat gaacagacat tgtattatga tgaatttacc tgatgtaggc 30180 aaatttggat ctagtatgtt ggggaaatat gaacctgaca tgattaagat tgctctttcg 30240 gtggctggta atttaataag aaatcgagac tacattcccg ggagacgagg atatagctac 30300 tacgtttacg gtatagcctc tagataattt ttttaagcac gaaataaaaa acataatttt 30360 aaaccaatct atttcatact attttgtgtg atcaccatgg acataaagat agatattagt 30420 atttctggtg ataaatttac ggtgactact aggagggaaa atgaagaaag aaaaaaatat 30480 ctacctctcc aaaaagaaaa aactactgat gttatcaaac ctgattatct tgagtacgat 30540 gacttgttag atagagatga gatgtttact attctag agg aatattttat gtacagaggt 30600 ctattaggcc tcagaataaa atatggacga ctctttaacg aaattaaaaa attcgacaat 30660 gatgcggaag aacaattcgg tactatagaa gaactcaagc agaaacttag attaaattct 30720 gaagagggag cagataactt tatagattat ataaaggtac aaaaacagga tatcgtcaaa 30780 cttactgtat acgattgcat atctatgata ggattgtgtg catgcgtggt agatgtttgg 30840 agaaatgaga aactgttttc tagatggaaa tattgtttac gagctattaa actgtttatt 30900 aatgatcaca tgcttgataa gataaaatct atactgcaga atagactagt atatgtggaa 30960 atgtcataga aagttaaaag ttaatgagag caaaaatata taaggttgta ttccatattt 31020 gttatttttt ctgtaatagt tagaaaaata cattcgatgg tctatctacc agattattat 31080 gtgttataag gtactttttc tcataataaa ctagagtatg agtaagatag tgtttttcaa 31140 aacatataaa tctaaaattg atggatgaga tatacagcta ttaatttcga aaatatattt 31200 taatctgata actttaaaca tggatttttg atggtggttt aacgttttaa aaaaagattt 31260 tgttattgta gtatatgata atattaaaag atggatataa agaatttgct gactgcatgt 31320 actatttttt acattactac attggctacg gcagatatac ctactccgcc accaacgggt 31380 catgtgacaa gggagaatat cttgataaga ggcataatca atgttgtaat cggtgtccac 31440 ctggagaatt tgccaaggtt agatgtaatg gtaacgataa cacaaaatgt gaacgctgcc 31500 cacctcatac atataccaca atcccaatta ttctaatgga tgtcatcaat gtagaaaatg 31560 cccaaccgga tcatttgata aggtaaagtg taccggaaca cagaacagta aatgttcgtg 31620 tcttcctggt tggtattgtg ctactgattc ttcacagact gaagattgtt gaaattgtgt 31680 accaaaaagg agatgtccat gcggatactt tggtggaata gatgaacaag gaaatcctat 31740 ttgtaaatcg tgttgtgttg gtgaatattg cgactaccta cgtaattata gacttgatcc 31800 atttcctcca tgcaaactat ctaaatgtaa ttaattatga ttttgatgat aatgttacca 31860 tacattatat cgctacttgg ttagtgtatt attcagtatg aagacctatt aataattact 31920 tatcttttga cgatcttgtt ataattataa tataaaaata cttatggcat agtaactcat 31980 aattgctgac gcgataaatt cgtaataatc tgttttgttc aaatttttat aaggaatcta 32040 caggcataaa aataaaaata taatttataa tatactctta cagcgcgcca tcatgaataa 32100 cagcagtgaa ttgattgctg ttattaatgg atttagaaat agtggacgat tttgtgatat 32160 tagtatagtt attaatgatg aaaggataaa cgctcataaa ctcatcctat ctggagcctc 32220 cgaatatttt tccattctgt tt tccaataa ttttatcgat tctaatgaat acgaagttaa 32280 tctaagtcat ttagattatc aaagcgttaa cgatttgatc gattacattt atgggatacc 32340 tttgagccta actaacgata acgtgaaata tattctttca accgctgatt ttttacaaat 32400 tggatctgct attacggagt gtgaaaatta catacttaaa aatctttgtt ctaaaaactg 32460 tatcgatttc tacatatacg ctgataaata taataacaag aaaatagaat cagcgtcgtt 32520 taacacaata ttacaaaata ttttgagact catcaacgat gaaaacttta aatacttaac 32580 agaggaatca atgataaaaa ttttaagcga tgatatgtta aatataaaaa atgaggattt 32640 tgcaccacta attctcatta aatggttaga gagtactcaa caatcatgca ccgtcgagtt 32700 acttagatgc ctcagaatat cattgctttc cccacaagtt ataaaatcac tttatagtca 32760 tcaactggtt agttcaatct acgaatgtat aacattctta aacaatatag cattcttgga 32820 tgaatcattt cctagatacc atagcatcga gttgatatct atcggtataa gtaattcgca 32880 tgataagatt tccataaact gctacaatca taaaaaaaat acatgggaaa tgatatcttc 32940 acgtagatat aggtgtagtt tcgcagtggc cgtcctggat aatattatct atatgatggg 33000 tggatatgat cagtccccgt atagaagttc aaaggttata gcgtacaata catgtacaaa 33060 ttcttggata tatga tatac cagagctaaa atatcctcgt tctaattgtg ggggactggc 33120 tgatgacgaa tacatttatt gtataggcgg catacgcgat caggattcat cgttgacatc 33180 tagtattgat aaatggaagc catcaaaacc atattggcag aagtatgcta aaatgcgcga 33240 accaaaatgt gatatggggg ttgcgatgtt aaacggatta atatatgtca tgggtggaat 33300 cgttaaaggt gacacgtgta ccgacgcact agagagttta tcagaagatg gatggatgaa 33360 gcatcaacgt cttccaataa aaatgtccaa tatgtcgacg attgttcatg atggcaagat 33420 ttatatatct ggaggttaca acaatagtag tgtagttaat gtaatatcga atctagtcct 33480 tagctataat ccgatatatg atgaatggac caaattatca tcattaaaca ttcctagaat 33540 taatcccgct ctatggtcag cgcataataa attatatgta ggaggaggaa tatctgatga 33600 tgttcgaact aatacatctg aaacatacga taaagaaaaa gattgttgga cattggataa 33660 tggtcacgtg ttaccacgca attatataat gtataaatgc gaaccgatta aacataaata 33720 tccattggaa aaaacacagt acacgaatga ttttctaaag tatttggaaa gttttatagg 33780 tagttgatag aacaaaatac ataattttgt aaaaataaat cactttttat actaatatga 33840 cacgattacc aatacttttg ttactaatat cattagtata cgctacacct tttcctcaga 33900 catctaaa aa aataggtgat gatgcaactc tatcatgtaa tcgaaataat acaaatgact 33960 acgttgttat gagtgcttgg tataaggagc ccaattccat tattctttta gctgctaaaa 34020 gcgacgtctt gtattttgat aattatacca aggataaaat atcttacgac tctccatacg 34080 atgatctagt tacaactatc acaattaaat cattgactgc tagagatgcc ggtacttatg 34140 tatgtgcatt ctttatgaca tcaactacaa atgacactga taaagtagat tatgaagaat 34200 actccacaga gttgattgta aatacagata gtgaatcgac tatagacata atactatctg 34260 gatctacaca ttcaccggaa actagttcta agaaacctga ttatatagat aattctaatt 34320 gctcgtcggt attcgaaatc gcgactccgg aaccaattac tgataatgta gaagatcata 34380 cagacaccgt cacatacact agtgatagca ttaatacagt aagtgcatca tctggagaat 34440 ccacaacaga cgagactccg gaaccaatta ctgataaaga agatcataca gttacagaca 34500 ctgtctcata cactacagta agtacatcat ctggaattgt cactactaaa tcaaccaccg 34560 atgatgcgga tctttatgat acgtacaatg ataatgatac agtaccacca actactgtag 34620 gcggtagtac aacctctatt agcaattata aaaccaagga ctttgtagaa atatttggta 34680 ttaccgcatt aattatattg tcggccgtgg caattttctg tattacatat tatatatata 34740 ataaacgttc acgtaaatac aaaacagaga acaaagtcta gatttttgac ttacataaat 34800 gtctgggata gtaaaatcta tcatattgag cggaccatct ggtttaggaa agacagccat 34860 agccaaaaga ctatgggaat atatttggat ttgtggtgtc ccataccact agatttcctc 34920 gtcctatgga acgagaaggt gttgattacc attacgttaa cagagaggcc atctggaagg 34980 gaatagccgc cggaaacttt ctagaacata ctgagttttt aggaaatatt tacggaactt 35040 ctaaaacagc tgtgaataca gcggctatta ataatcgtat ttgtgtgatg gatctaaaca 35100 tcgacggtgt tagaagtctt aaaaatacgt acctaatgcc ttactcggtg tatataagac 35160 ctacctctct taaaatggtt gagaccaagc ttcgttgtag aaacactgaa gctaacgatg 35220 agattcatcg tcgcgtgata ttggcaaaaa cggatatgga tgaggccaac gaagcaggtc 35280 tattcgacac tattatcatt gaagatgatg tgaatttagc atatagtaag ttaattcaga 35340 tactacagga ccgtattaga atgtatttta acactaatta gagacttaag acttaaaact 35400 tgataattaa taatataact cgtttttata tgtggctatt tcaacgtcta atgtattagt 35460 taaatattaa aacttaccac gtaaaactta aaatttaaaa tgatatttca ttgacagata 35520 gatcacacat tatgaacttt caaggacttg tgttaactga caattgcaaa aatcaatgg g 35580 tcgttggacc attaatagga aaaggtggat tcggtagtat ttatactact aatgacaata 35640 attatgtagt aaaaatagag cccaaagcta acggatcatt atttaccgaa caggcatttt 35700 atactagagt acttaaacca tccgttatcg aagaatggaa aaaatctcac aatataaagc 35760 acgtaggtct tatcacgtgc aaggcatttg gtctatacaa atccattaat gtggaatatc 35820 gattcttggt aattaataga ttaggtgcag atctagatgc ggtgatcaga gccaataata 35880 atagattacc aaaaaggtcg gtgatgttga tcggaatcga aatcttaaat accatacaat 35940 ttatgcacga gcaaggatat tctcacggag atattaaagc gagtaatata gtcttggatc 36000 aaatagataa gaataaatta tatctagtgg attacggatt ggtttctaaa ttcatgtcta 36060 atggagaaca tgttccattt ataagaaatc caaataaaat ggataacggt actctagaat 36120 ttacacctat agattcgcat aaaggatacg ttgtatctag acgtggagat ctagaaacac 36180 ttggatattg tatgattaga tggttgggag gtatcttgcc atggactaag atatctgaaa 36240 caaagaattg tgcattagta agtgccacaa aacagaaata tgttaacaat actgcgactt 36300 tgttaatgac cagtttgcaa tatgcaccta gagaattgct gcaatatatt accatggtaa 36360 actctttgac atattttgag gaacccaatt atgacgagtt tcggcacata t taatgcagg 36420 gtgtatatta ttaagtgtgg tgtttggtcg atgtaaaatt tttgtcgata aaaattaaaa 36480 aataacttaa tttattattg atctcgtgtg tacaaccgaa atcatggcga tgttttacgc 36540 acacgctctc ggtgggtacg acgagaatct tcatgccttt cctggaatat catcgactgt 36600 tgccaatgat gtcaggaaat attctgttgt gtcagtttat aataacaagt atgacattgt 36660 aaaagacaaa tatatgtggt gttacagtca ggtgaacaag agatatattg gagcactgct 36720 gcctatgttt gagtgcaatg aatatctaca aattggagat ccgatccatg atcaagaagg 36780 aaatcaaatc tctatcatca catatcgcca caaaaactac tatgctctaa gcggaatcgg 36840 gtacgagagt ctagacttgt gtttggaagg agtagggatt catcatcacg tacttgaaac 36900 aggaaacgct gtatatggaa aagttcaaca tgattattct actatcaaag agaaggccaa 36960 agaaatgaat gcacttagtc caggacctat cattgattac cacgtctgga taggagattg 37020 tatctgtcaa gttactgctg tggacgtaca tggaaaggaa attatgagaa tgagattcaa 37080 aaagggtgcg gtgcttccga tcccaaatct ggtaaaagtt aaacttgggg agaatgatac 37140 agaaaatctt tcttctacta tatcggcggc accatcgagg taaccacctc tctggaagac 37200 agcgtgaata atgtactcat gaaacgtttg gaaactatac gcca tatgtg gtctgtcgta 37260 tatgatcatt ttgatattgt gaatggtaaa gaatgctgtt atgtgcatac gcatttgtct 37320 aatcaaaatc ttataccgag tactgtaaaa acaaatttgt acatgaagac tatgggatca 37380 tgcattcaaa tggattccat ggaagctcta gagtatctta gcgaactgaa ggaatcaggt 37440 ggatggagtc ccagaccaga aatgcaggaa tttgaatatc cagatggagt ggaagacact 37500 gaatcaattg agagattggt agaggagttc ttcaatagat cagaacttca ggctggtgaa 37560 tcagtcaaat ttggtaattc tattaatgtt aaacatacat ctgtttcagc taagcaacta 37620 agaacacgta tacggcagca gcttccttta tactctcatc ttttaccaac acaaagggtg 37680 gatatttgtt cattggagtt gataataata cacacaaagt aattggattc acggtgggtc 37740 atgactacct cagactggta gagaatgata tagaaaagca tatcaaaaga cttcgtgttg 37800 tgcatttctg tgagaagaaa gaggacatca agtacacgtg tcgattcatc aaggtatata 37860 aacctgggga tgaggctacc tcgacatacg tgtgcgctat caaagtggaa agatgctgtt 37920 gtgctgtgtt tgcagattgg ccagaatcat ggtatatgga tactaatggt atcaagaagt 37980 attctccaga tgaatgggtg tcacatataa aattttaatt aatgtaatag agaacaaata 38040 ataaggttgt aatatcatat agacaataac taacaat taa ttagtaactg ttatctcttt 38100 tttaactaac caactaacta tatacctatt aatacatcgt aattatagtt cttaacatct 38160 attaatcatt aattcgcttc tttaattttt tataaactaa cattgttaat tgaaaaggga 38220 taacatgtta cagaatataa attatatatg gattttttta aaaaggaaat acttgactgg 38280 agtatatatt tatctcttca ttatatagca cgcgtgtttt ccaatttttc cacatcccat 38340 ataatacagg attataatct cgttcgaaca tacgagaaag tggataaaac aatagttgat 38400 tttttatcta ggttgccaaa tttattccat attttagaat atggggaaaa tattctacat 38460 atttattcta tggatgatgc taatacgaat attataattt tttttctaga tagagtatta 38520 aatattaata agaacgggtc atttatacac aatctcaggt tatcatcatc cattaatata 38580 aaagaatatg tatatcaatt agttaataat gatcatccag ataataggat aagactaatg 38640 cttgaaaatg gacgtagaac aagacatttt ttgtcctata tatcagatac agttaatatc 38700 tatatatgta ttttaataaa tcatggattt tatatagatg ccgaagacag ttacggttgt 38760 acattattac atagatgtat atatcactat aagaaatcag aatcagaatc atacaatgaa 38820 ttaattaaga tattgttaaa taatggatca gatgtagata aaaaagatac gtacggaaac 38880 acacctttta tcctattatg taaacacgat atcaacaacg tggaattgtt tgagatatgt 38940 ttagagaatg ctaatataga ctctgtagac tttaatagat atacacctct tcattatgtc 39000 tcatgtcgta ataaatatga ttttgtaaag ttattaattt ctaaaggagc aaatgttaat 39060 gcgcgtaata gattcggaac tactccattt tattgtggaa ttatacacgg tatctcgctt 39120 ataaaactat atttggaatc agacacagag ttagaaatag ataatgaaca tatagttcgt 39180 catttaataa tttttgatgc tgttgaatct ttagattatc tattatccag aggagttatt 39240 gatattaact atcgtactat atacaacgaa acatctattt acgacgctgt cagttataat 39300 gcgtataata cgttggtcta tctattaaac agaaatggtg attttgagac gattactact 39360 agtggatgta catgtatttc ggaagcagtc gcaaacaaca acaaaataat aatggaagta 39420 ctattgtcta aacgaccatc tttgaaaatt atgatacagt ctatgatagc aattactaaa 39480 cataaacagc ataatgcaga tttattgaaa atgtgtataa aatatactgc gtgtatgacc 39540 gattatgata ctcttataga tgtacagtcg ctacagcaat ataaatggta tattttaaaa 39600 tgtttcgatg aaatagatat catgaagaga tgttatataa aaaataaaac tgtattccaa 39660 ttagtttttt gtatcaaaga cattaatact ttaatgagat acggtaaaca tccttctttc 39720 gtgaaatgca ctagtctcga cg tatacgga agtcgtgtac gtaatatcat agcatctatt 39780 agatatcgtc agagattaat tagtctatta tccaagaagc tggatcctgg agataaatgg 39840 tcgtgttttc ctaacgaaat aaaatataaa atattggaaa actttaacga taacgaacta 39900 tccacatatc taaaaatctt ataaacacta ttaaaatata aaatctaagt aggataaaat 39960 cacactacat cattgtttcc ttttagtgct cgacagtgta tactattttt aacactcata 40020 aataaaaatg aaaacgattt ccgttgttac gttgttatgc gtactacctg ctgttgttta 40080 ttcaacatgt actgtaccca ctatgaataa cgctaaatta acgtctaccg aaacatcgtt 40140 taatgataaa cagaaagtta cgtttacatg tgatcaggga tatcattctt cggatccaaa 40200 tgctgtctgc gaaacagata aatggaaata cgaaaatcca tgcaaaaaaa tgtgcacagt 40260 ttctgattac atctctgaat tatataataa accgctatac gaagtgaatt ccaccatgac 40320 actaagttgc aacggcgaaa caaaatattt tcgttgcgaa gaaaaaaatg gaaatacttc 40380 ttggaatgat actgttacgt gtcctaatgc ggaatgtcaa cctcttcaat tagaacacgg 40440 atcgtgtcaa ccagttaaag aaaaatactc atttggggaa tatatgacta tcaactgtga 40500 tgttggatat gaggttattg gtgcttcgta cataagttgt acagctaatt cttggaatgt 40560 tattccatca tgtca acaaa aatgtgatat gccgtctcta tctaatggat taatttccgg 40620 atctacattt tctatcggtg gcgttataca tcttagttgt aaaagtggtt ttacactaac 40680 ggggtctcca tcatccacat gtatcgacgg taaatggaat cccgtactcc caatatgtgt 40740 acgaactaac gaagaatttg atccagtgga tgatggtccc gacgatgaga cagatttgag 40800 caaactctcg aaagacgttg tacaatatga acaagaaata gaatcgttag aagcaactta 40860 tcatataatc atagtggcgt taacaattat gggcgtcata tttttaatct ccgttatagt 40920 attagtttgt tcctgtgaca aaaataatga ccaatataag ttccataaat tgctaccgta 40980 aatataaatc cgttaaaata atgaataatt aataacgaac aagtatcaaa agattaaaga 41040 attatagcta gaatcaattg agatgtcttc ttcagtggat gttgatatct acgatgccgt 41100 tagagcattt ttactcaggc actattataa caagagattt attgtgtatg gaagaagtaa 41160 cgccatatta cataatatat acaggctatt tacaagatgc gccgttatac cgttcgatga 41220 tatagtacgt actatgccaa atgaatcacg tgttaaacaa tgggtgatgg atacacttaa 41280 tggtataatg atgaatgaac gcgatgtttc tgtaagcgtt ggcaccggaa tactattcat 41340 ggaaatgttt ttcgattaca ataaaaatag tatcaacaat caactaatgt atgatataat 41400 taatagcgta tctataattc tagctaatga gagatataga agcgctttta acgacgatgg 41460 tatatacatc cgtagaaata tgattaacaa gttgtacgga tacgcatctc taactactat 41520 tggcacgatc gctggaggtg tttgttatta tctgttgatg catctagtta gtttgtataa 41580 ataattattt caatatacta gttaaaattt taagatttta aatgtataaa aaactaata a 41640 cgtttttatt tgtaataggt gcattagcat cctattcgaa taatgagtac actccgttta 41700 ataaactgag tgtaaaactc tatatagatg gagtagataa tatagaaaat tcatatactg 41760 atgataataa tgaattggtg ttaaatttta aagagtacac aatttctatt attacagagt 41820 catgcgacgt cggatttgat tccatagata tagatgttat aaacgactat aaaattattg 41880 atatgtatac cattgactcg tctactattc aacgcagagg tcacacgtgt agaatatcta 41940 ccaaattatc atgccattat gataagtacc cttatattca caaatatgat ggtgatgagc 42000 gacaatattc tattactgca gagggaaaat gctataaagg aataaaatat gaaataagta 42060 tgatcaacga tgatactcta ttgagaaaac atactcttaa aattggatct acttatatat 42120 ttgatcgtca tggacatagt aatacatatt attcaaaata tgatttttaa aaatttaaaa 42180 tatattatca cttcagtgac agtagtcaaa taacaaacaa caccatgaga tatattataa 42240 ttctcgcagt tttgttcatt aatagtatac acgctaaaat aactagttat aagtttgaat 42300 ccgtcaattt tgattccaaa attgaatgga ctggggatgg tctatacaat atatccctta 42360 aaaattatgg catcaagacg tggcaaacaa tgtatacaaa tgtaccagaa ggaacatacg 42420 acatatccgc atttccaaag aatgatttcg tatctttctg ggttaaattt g aacaaggcg 42480 attataaagt ggaagagtat tgtacgggac tatgcgtcga agtaaaaatt ggaccaccga 42540 ctgtaacatt gactgaatac gacgaccata tcaatttgta catcgagcat ccgtatgcta 42600 ctagaggtag caaaaagatt cctatttaca aacgcggtga catgtgtgat atctacttgt 42660 tgtatacggc taacttcaca ttcggagatt ctaaagaacc agtaccatat gatatcgatg 42720 actacgattg cacgtctaca ggttgcagca tagactttgt cacaacagaa aaagtgtgcg 42780 tgacagcaca gggagccaca gaagggtttc tcgaaaaaat tactccatgg agttcgaaag 42840 tatgtctgac acctaaaaag agtgtatata catgcgcaat tagatccaaa gaagatgttc 42900 ccaatttcaa ggacaaaatg gccagagtta tcaagagaaa atttaataaa cagtctcaat 42960 cttatttaac taaatttctc ggtagcacat caaatgatgt taccactttt cttagcatgc 43020 ttaacttgac taaatattca taactaattt ttattaatga tacaaaaacg aaataaaact 43080 gcatattata cactggttaa cgcccttata ggctctaacc attttcaaga tgaggtccct 43140 gattatagtc cttctgttcc cctctatcat ctactccatg tctattagac aatgtgagaa 43200 gactgaagag gaaacatggg gattgaaaat agggttgtgt ataattgcca aagatttcta 43260 tcccgaaaga actgattgca gtgttcatct cccaactgca agtg aaggat tgataactga 43320 aggcaatgga ttcagggata tacgaaacac cgataaatta taaaaaaagc aatgtgtccg 43380 ctgtttccgt taataatact attttcgtaa ctggcggatt attcataaat aactctaata 43440 gcacgatcgt ggttaacaat atggaaaaac ttgacattta taaagacaaa caatggtcga 43500 ttatagaaat gcctatggct agggtatatc acggcatcga ctcgacattt ggaatgttat 43560 attttgccgg aggtctatcc gttaccgaac aatatggtaa tttagagaaa aacaacgaga 43620 tatcttgtta caatcctaga acgaataagt ggtttgatat ttcatatact atttataaga 43680 tatccatatc atcattgtgt aaactaaata acgtcttcta tgtatttagt aaggacattg 43740 gatatgtgga aaagtatgat ggtgcatgga agttagtaca tgatcgtctc cccgctataa 43800 aggcattatc aacttctcct tattgattga aaatgaaaat ataaatagtt tttatgtata 43860 gcagtattac cctatagttt tattgcttac tactaacatg gatacagatg ttacaaatgt 43920 agaagatatc ataaatgaaa tagatagaga gaaagaagaa atactaaaaa atgtagaaat 43980 tgaaaataat aaaaacatta acaagaatca tccaagtgga tatattagag aagcactcgt 44040 tattaatacc agtagtaata gtgattccat tgataaagaa gttatagaat gtatctgtca 44100 cgatgtagga atatagatca tatctactaa tttttat aat cgatacaaaa cataaaaaac 44160 aactcgttat tacatagcag gcatggaatc cttcaagtat tgttttgata acgatggcaa 44220 gaaatggatt atcggaaata ctttatattc tggtaattca atactatata aggtcagaaa 44280 aaatttcact agttcgttct acaattacgt aatgaagata gatcacaaat cacacaagcc 44340 attgttgtct gaaatacgat tctatatatc tgtattggat cctttgacta tcgacaactg 44400 gacacgggaa cgtggtataa agtatttggc tattccagat ctgtatggaa ttggagaaac 44460 cgatgattat atgttcttcg ttataaagaa tttgggaaga gtattcgccc caaaggatac 44520 tgaatcagtc ttcgaagcat gcgtcactat gataaacacg ttagagttta tacactctca 44580 aggatttacc catggaaaaa tagaaccgag gaatatactg attagaaata aacgtctttc 44640 actaattgac tattctagaa ctaacaaact atacaagagt ggaaactcac atatagatta 44700 caacgaggac atgataactt caggaaatat caattatatg tgtgtagaca atcatcttgg 44760 agcaacagtt tcaagacgag gagatttaga aatgttggga tattgcatga tagaatggtt 44820 cggtggcaaa cttccatgga aaaacgaaag tagtataaaa gtaataaaac aaaaaaaaga 44880 atataaaaaa tttatagcta ctttctttga ggactgtttt cctgaaggaa atgaacctct 44940 ggaattagtt agatatatag aattagtata cacgttagat tattctcaaa ctcctaatta 45000 tgacagacta cgtaaactgt ttatacaaga ttgaaattat attctttttt ttatagagtg 45060 tggtagtgtt acggatattt aatattagac tatctctatc gcgctacacg accaatatcg 45120 attactatgg atatcttcag ggaaatcgca tcttctatga aaggagagaa tgtattcatt 45180 tctccagcgt caatctcgtc agtattgaca atactgtatt atggagctaa tggatccact 45240 gctgaacagc tatcaaaata tgtagaaaag gaggagaaca tggataaggt tagcgctcaa 45300 aatatctcat tcaaatccat aaataaagta tatgggcgat attctgccgt gtttaaagat 45360 tcctttttga gaaaaattgg cgataagttt caaactgttg acttcactga ttgtcgcact 45420 atagatgcaa tcaacaagtg tgtagatatc tttactgagg ggaaaatcaa tccactattg 45480 gatgaaccat tgtctcctga tacctgtctc ctagcaatta gtgccgtata ctttaaagca 45540 aaatggttga cgccattcga aaaggaattt accagtgatt atccctttta cgtatctccg 45600 acggaaatgg tagatgtaag tatgatgtct atgtacggca aggcatttaa tcacgcatct 45660 gtaaaggaat cattcggcaa cttttcaatc atagaactgc catatgttgg agatactagt 45720 atgatggtca ttcttccaga caagattgat ggattagaat ccatagaaca aaatctaaca 45780 gatacaaatt ttaagaaatg gt gtaactct ctggaagcta cgtttatcga tgttcacatt 45840 cccaagttta aggtaacagg ctcgtataat ctggtggata ctctagtaaa gtcaggactg 45900 acagaggtgt tcggttcaac tggagattat agcaatatgt gtaattcaga tgtgagtgtc 45960 gacgctatga tccacaaaac gtatatagat gtcaatgaag agtatacaga agcagctgca 46020 gcaacttgtg cactggtgtc agactgtgca tcaacaatta caaatgagtt ctgtgtagat 46080 catccgttca tctatgtgat taggcatgtt gatggaaaaa ttcttttcgt tggtagatat 46140 tgctctccga caactaattg ttaaccattt tttttaaaaa atagaaaaaa catgtggtat 46200 tagtgcaggt cgttattctt ccaattgcaa ttggtaagat gacggccaac tttagtaccc 46260 acgtcttttc accacagcac tgtggatgtg acagactgac cagtattgat gacgtcagac 46320 aatgtttgac tgaatatatt tattggtcgt cctatgcata ccgcaacagg caatgcgctg 46380 gacaattgta ttccacactc ctctctttta gagatgatgc ggaattagtg ttcatcgaca 46440 ttcgcgagct ggtaaaaaat atgccgtggg atgatgtcaa agattgtgca gaaatcatcc 46500 gttgttatat accggatgag caaaaaacca tcagagagat ttcggccatc atcggacttt 46560 gtgcatatgc tgctacttac tggggaggtg aagaccatcc cactagtaac agtctgaacg 46620 cattgtttgt gatgc ttgag atgctcaatt acgtggatta taacatcata ttccggcgta 46680 tgaattgatg agttgtacat cttgacattt tcttctttct tctcttctcc ctttcccaga 46740 aacaaacttt ttttacccac tataaaataa aatgagtata ctacctgtta tatttctttc 46800 tatatttttt tattcttcat tcgttcagac ttttaacgcg cctgaatgta tcgacaaagg 46860 gcaatatttt gcatcattca tggagttaga aaacgagcca gtaatcttac catgtcctca 46920 aataaatacg ctatcatccg gatataatat attagatatt ttatgggaaa aacgaggagc 46980 ggataatgat agaattatac cgatagataa tggtagcaat atgctaattc tgaacccgac 47040 acaatcagac tctggtattt atatatgcat taccacgaac gaaacctact gtgacatgat 47100 gtcgttaaat ttgacaatcg tgtctgtctc agaatcaaat atagatctta tctcgtatcc 47160 acaaatagta aatgagagat ctactggcga aatggtatgt cccaatatta atgcatttat 47220 tgctagtaac gtaaacgcag atattatatg gagcgggcat cgacgcctta gaaataagag 47280 acttaaacaa cggacacctg gaattattac catagaagat gttagaaaaa atgatgctgg 47340 ttattataca tgtgttttag aatatatata cggtggcaaa acatataacg taaccagaat 47400 tgtaaaatta gaggtacggg ataaaataat accttctact atgcaattac cagatggcat 47460 tgtaactt ca ataggtagta atttgactat tgcatgcaga gtatcgttga gacctcccac 47520 aacggatgca gacgtctttt ggataagtaa tggtatgtat tacgaagaag atgatgggga 47580 cggaaacggt agaataagtg tagcaaataa aatctatatg accgataaga gacgtgttat 47640 tacatcccgg ttaaacatta atcctgtcaa ggaagaagat gctacaacgt ttacgtgtat 47700 ggcgtttact attcctagca tcagtaaaac agttactgtt agtataacgt gaatgtatgt 47760 tgttacattt ccatgtcaat tgagtttata agaattttta tacattatct tccaacaagc 47820 aattgacgaa cgtattgcta tgattaactc ccacgatact atgcatatta ttaatcatta 47880 acttgcagac tatacctaga gctattttga catactcgtg ttcttgtgta attgcagtat 47940 ctatattatt aaagtacgta aatctagcta tagttttatt atttaatttt agataatata 48000 ccgtctcctt atttttaaaa attgccacat cctttattaa atcatgaatg ggaatttcta 48060 tgtcatagtt aatatattgt gaacaacaag agcagatatc tataggaaag ggtggaatgc 48120 gatacattga tctatgtagt tttaaaacac acgcaaactt tgaagaattt atataaatca 48180 ttccatcgat acatccttct atgttgagat gtatatatcc aggaattcgt ttattaatat 48240 cgggaaatgt ataaactaaa acattgcccg gaagcggagc ttctaccgga gttatatcag 48300 tttttaactt acaaaatgta accaatacct ttgcatgact tgttttgttc ggcaacgtta 48360 gtttaaactt gacgaatgga ttaattacaa tagcatgatc cgcgcatcta ttaagttttt 48420 ttactttaac gcccttgtat gtttttacag agactttatc taaatttcta gtgcttgtat 48480 gtgttataaa tataacggga tatagaactg aatcacctac cttagatacc caattacatt 48540 ttatcagatc cagataataa acaaattttg tcgccctaac taattctata ttgttatata 48600 ttttacaatt ggttatgata tcatgtaata acttggaatc taacgcacat cgtcgtacgt 48660 ttatacaatt gtgatttagt gtagtatatc tacacatgta tttttccgcg ctatagtatt 48720 ctggactagt gataaaacta tcgttatatc tgtcttcaat gaactcatcg agatattgct 48780 ctctgtcata ttcatacacc tgcataaact ttctagacat cttacaatcc gtgttatttt 48840 aggatcatat ttacatattt acgggtatat caaagatgtt agattagtta atgggaatcg 48900 tctataataa tgaatattaa acaattatat gaggactttt accacaaagc atcataaaaa 48960 tgagtcgtcg tctgatttat gttttaaata tcaaccgcga atcaactcat aaaatacaag 49020 agaatgaaat atatacatat tttagtcatt gcaatataga ccatacttct acagaacttg 49080 attttgtagt taaaaactat gatctaaaca gacgacaacc tgtaactggg tatactgca c 49140 tacactgcta tttgtataat aattacttta caaacgatgt actgaagata ttattaaatc 49200 atggagtgga tgtaacgatg aaaaccagta gcggacgtat gcctgtttat atattgctta 49260 ctagatgttg caatatttca catgatgtag tgatagatat gatagacaaa gataaaaacc 49320 acttattaca tagagactat tccaacctat tactagagta tataaaatct cgttacatgt 49380 tattaaagga agaggatatc gatgagaaca tagtatccac tttattagat aagggaatcg 49440 atcctaactt taaacaagac ggatatacag cgttacatta ttattatttg tgtctcgcac 49500 acgtttataa accaggtgag tgtagaaaac cgataacgat aaaaaaggcc aagcgaatta 49560 tttctttgtt tatacaacat ggagctaatc taaacgcgtt agataattgt ggtaatacac 49620 cattccattt gtatcttagt attgaaatgt gtaataatat tcatatgact aaaatgctgt 49680 tgacttttaa tccgaatttc gaaatatgta ataatcatgg attaacgcct atactatgtt 49740 atataacttc cgactacata caacacgata ttcttgttat gttaatacat cactatgaaa 49800 caaatgttgg agaaatgccg atagatgagc gtcgtataat cgtattcgag tttatcaaaa 49860 catattctac acgtcctgca gattcgataa cttatttgat gaataggttt aaaaatatag 49920 atatttatac ccgctatgaa ggaaagacat tattacacgt agcatgtgaa t ataataata 49980 cacacgtaat agattatctt atacgtatca acggagatat aaatgcgtta accgacaata 50040 acaaacacgc tacacaactc attatagata acaaagaaaa ttccccatat accattaatt 50100 gtttactgta tatacttaga tatattgtag ataagaatgt gataagatcg ttggtggatc 50160 aacttccatc tctacctatc ttcgatataa aatcatttga gaaattcata tcctactgta 50220 tacttttaga tgacacattt tacaatagac acgttaggaa tcgcgattct aaaacgtatc 50280 gatacgcatt ttcaaaatac atgtcgtttg ataaatacga tggtataata actaaatgtc 50340 ataaagaaac aatattgctc aaactatcca ctgttctaga cactacacta tatgcagttt 50400 taagatgcca taattcgaaa aagttaagaa gatacctcac cgagttaaaa aaatataata 50460 acgataagtc ctttaaaata tattctaata ttatgaatga gagatacctt aatgtatatt 50520 ataaagatat gtacgtgtca aaggtatatg ataaactatt tcctgttttc acagataaaa 50580 attgtctact aacattacta ccttcagaaa ttatatacga aatattatac atgctgacaa 50640 ttaacgatct ttataatata tcgtatccac ctaccaaagt atagttgtat ttttctcatg 50700 cgatgtgtgt aaaaaaactg atattatata aatattttag tgccgtataa taaagatgac 50760 gatgaaaatg atggtacata tatatttcgt atcattattg ttat tgctat tccacagtta 50820 cgccatagac atcgaaaatg aaatcacaga attcttcaat aaaatgagag atactctacc 50880 agctaaagac tctaaatggt tgaatccagc atgtatgttc ggaggcacaa tgaatgatat 50940 agccgctcta ggagagccat tcagcgcaaa gtgtcctcct attgaagaca gtcttttatc 51000 gcacagatat aaagactatg tggttaaatg ggaaaggcta gaaaaaaata gacggcgaca 51060 ggtttctaat aaacgtgtta aacatggtga tttatggata gccaactata catctaaatt 51120 cagtaaccgt aggtatttgt gcaccgtaac tacaaagaat ggtgactgtg ttcagggtat 51180 agttagatct catattagaa aacctccttc atgcattcca aaaacatatg aactaggtac 51240 tcatgataag tatggcatag acttatactg tggaattctt tacgcaaaac attataataa 51300 tataacttgg tataaagata ataaggaaat taatatcgac gacattaagt attcacaaac 51360 gggaaaggaa ttaattattc ataatccaga gttagaagat agcggaagat acgactgtta 51420 cgttcattac gacgacgtta gaatcaagaa tgatatcgta gtatcaagat gtaaaatact 51480 tacggttata ccgtcacaag accacaggtt taaactaata ctagatccaa aaatcaacgt 51540 aacgatagga gaacctgcca atataacatg cactgctgtg tcaacgtcat tattgattga 51600 cgatgtactg attgaatggg aaaatccatc cggatgg ctt ataggattcg attttgatgt 51660 atactctgtt ttaactagta gaggcggtat taccgaggcg accttgtact ttgaaaatgt 51720 tactgaagaa tatataggta atacatataa atgtcgtgga cacaactatt attttgaaaa 51780 aacccttaca actacagtag tattggagta aatatacaat gcatttttat atacattact 51840 gaataattat tattattatt tatatcgtat ttgtgctata acgcgactat ctaggtattt 51900 gtatctcacc gatagagaac atataaatgt agactctatt aaacagttgt gtaaaatatc 51960 agatcctaat gcatgttata gatgtggatg tacggcttta catgagtact tttataatta 52020 tagatcagtc aacggaaaat acaagtatag atacaacggt tactatcaat attatttatc 52080 tagcgattat gaaaattata atgaatatta ttatgatgat tatgatagaa ctggtatgaa 52140 cagtgagagt gataatatat caatcaaaac agaatatgaa ttctatgatg aaacacaaga 52200 tcaaagtaca caactagtag gttacgacat taaactcaaa accaatgagg atgattttat 52260 ggctatgata gatcagtggg tgtccatgat tatatagatg aatcaattaa taaagtagta 52320 tatggaagag agtctcacgt aagatggcgg gatatatggc aagaacataa tgatggcgta 52380 tacagtatag gaaaggagtg catagataat atatacgaag acaaccatac cgtagacgaa 52440 ttctacaaga tagacagcgt atcagatgta gatgacgcgg aacacatatc tccgataact 52500 aatgatgtat ctacacaaac atgggaaaag aaatcagagt tagatagata catggaaatg 52560 tatcctcgtc atagatatag taagcattct gtctttaagg gattttctga caaagttaga 52620 aaaaatgatt tagacatgaa tgtggtaaaa gaattacttt ctaacggtgc atctctaaca 52680 attaaggata gcagtaataa ggatccaata accgtttatt ttcgaagaac gataatgaat 52740 ttagaaatga ttgatgaacg aaagtatata gtacactcct atctaaaaaa ttataaaaat 52800 ttcgattatc catttttcag gaagttagtt ttgactaata aacattgtct caacaattat 52860 tataatataa gcgacagcaa atatggaaca ccgctacata tattggcgtc taataaaaaa 52920 ttaataactc ctaattacat gaagttatta gtgtataacg gaaatgatat aaacgcacga 52980 ggtgaagata cacaaatgcg aactccatta cacaaatatt tgtgtaaatt tgtatatcat 53040 aatattgaat atggtatccg atactataat gaaaagatta tagacgcatt tatagagtta 53100 ggagccgatc taactattcc aaatgacgat ggaatgatac cagtagttta ctgtatacac 53160 tcaaatgccg aatatggtta taacaatatt actaacataa agataatacg taaactactt 53220 aatcttagta gacgtgcgtc acataatcta tttagagatc gagtcatgca cgattatata 53280 agtaatacat atattgatct tg agtgttta gatattatta gatcgttgga tggattcgat 53340 atcaatggtt actttgaagg acgtacacca cttcattgcg ctatacaaca taacttcact 53400 cagattgcta agtacttatt agatcgagga gctgatatag tcgtacccaa cacattgatt 53460 atacatcagt acatacagta aatagcatag atatggagga ggatacaaat atttcaaata 53520 aagttataag gtacaacact gtcaataata tatgggaaac attacctaac ttctggactg 53580 gaactataaa tccaggcgtg gtctcgcata aagatgatat atatgttgta tgcgacatca 53640 aagatgaaaa aaatgttaaa acttgtatat ttagatataa cacgaatacg tataacggat 53700 gggaattggt cacgacgaca gaaagcagat tatcagctct gcatactatt ctttataaca 53760 ataccataat gatgttacat tgttatgaat cgtatatgtt acaagataca tttaatgtgt 53820 acactcgcga atggaatcat atgtgtcatc aacattcgaa tagttatatc atgtacaata 53880 tactacccat ctactaaata taatagaata aaataaatga gtatgatcat tttagataac 53940 gattgatttt atcattaccg cttcattctt atattctttg cttacggaac ctatatttag 54000 aaacatctac taacgatttt ttatgcttgc attattaatg gtatgtaata tgattgattg 54060 tgtacgcaat accaatttgt taagtatgaa tacggggtac aaacataaac tgaagtttaa 54120 cattatttat ttatg atata tatcgttatt gtttggtcta taccatggat atctttaaag 54180 aactaatctt aaaacacacg gatgaaaatg ttttgatttc tccagtttct attttatcta 54240 ctttatctat tctaaatcat ggagcagctg gttctacagc tgaacaacta tcaaaatata 54300 tagagaatat gaatgagaat acacccgatg acaataatga catggacgta gatattccgt 54360 attgtgcgac actagctacc gcaaataaaa tatacggtag cgatagtatc gagttccacg 54420 cctccttcct acaaaaaata aaagacgatt ttcaaactgt aaactttaat aatgctaacc 54480 aaacaaagga actaatcaac gaatgggtta agacaatgac aaatggtaaa attaattcct 54540 tattgactag tccgctatcc attaatactc gtatgacagt tgttagcgcc gtccatttta 54600 aagcaatgtg gaaatatcca ttttctaaac atcttacata tacagacaag ttttatattt 54660 ctaagaatat agttaccagt gttgatatga tggtgagcac tgagaataac ttgcaatatg 54720 tacatattaa tgaattattc ggaggattct ctattatcga tattccatac gagggaaact 54780 ctagtatggt aattatacta ccggacgaca tagaaggtat atataacata gaaaaaaata 54840 taacagatga aaaatttaaa aaatggtgtg gtatgttatc tactaaaagt atagacttgt 54900 atatgccaaa gtttaaagtg gaaatgacag aaccgtataa tctggtaccg attttagaaa 54960 atttaggact tactaatata ttcggatatt atgcagattt tagcaagatg tgtaatgaaa 55020 ctatcactgt agaaaaattt ctacatacga cgtttataga tgttaatgag gagtatacag 55080 aagcatcggc cgttacagga gtatttatga ctaacttttc gatggtatat cgtacgaagg 55140 tctacataaa ccatccattc atgtacatga ttaaagacaa cacaggacgt atacttttt a 55200 tagggaaata ctgctatccg caataaatat aaacaaatag acttttatca cgtttatcta 55260 tgtctaaata ttacaaatag taatagtata aactaaagct gataatactt aaaaaaataa 55320 taatatcatt tacaattaat agtataaact aaaaattaaa caaatcgtta ttataagtaa 55380 tatcaaaatg atgatatacg gattaatagc gtgtcttata ttcgtgactt catccatcgc 55440 tagtccactt tatattcccg ttattccacc catttcggaa gataaatcgt tcaatagtgt 55500 agaggtatta gtttccttgt ttagagatga ccaaaaagac tatacggtaa cttctcagtt 55560 caataactac actatcgata ccaaagactg gactatcggc gtactatcca cacctgatgg 55620 tttggatata ccattgacta atataactta ttggtcacgg tttactatag gtcgtgcatt 55680 gttcaaatca gagtctgagg atattttcca aaagaaaatg agtattctag gtgtttctat 55740 agaatgtaag aagtcgtcga cattacttac ttttttgacc gtgcgtaaaa tgactcgagt 55800 atttaataaa tttccagata tggcttatta tcgaggagac tgtttaaaag ccgtttatgt 55860 aacaatgact tataaaaata ctaaaactgg agagactgat tacacgtacc tctctaatgg 55920 ggggttgcct gcatactatc gtaatggggt cgatggttga ttattgatta gtatattcct 55980 tattcttttt attcacacaa aaagaacatt tttataaaca tgaaaccact g tctaaatgt 56040 aattatgatc ttgatttata gatgaagatc agcctttaga ggattttaac cagtatgttt 56100 aatatgaaaa aaataaacat aacatatttt gagattaagc gctattgtgc aagattatat 56160 tagaatcaaa ttaatctttc atacgagaaa aataacgaca tacgtcgtca acaaattaaa 56220 ctttttattt attagttaac tagcttatag aacttgctca ttgttatgtt tctaaaacgg 56280 gtacgacata taggacaatt atccgacgca ccggtttctc ttcgtgtttt atgccatata 56340 ttgatgcatg ttatgcaaaa tatatgagta cacgaatcca ataaaccaaa gtatctatcg 56400 ttttgagtaa acaacttcat agcaaattcc acattctttt tctttactta ctctatacac 56460 gtcctcgtat ttatccagta ttttgatgat atccaactca gaaatggttg ttgtattatt 56520 gggtgtattg ggagtatagg tattattagc tatgtaccaa tttaccaacc ctcttaatat 56580 tgattgaaca atcacatcgg ttatccaatc aataaccaca ttaataacta aattgtagtg 56640 tatatataga ccatatatgt ttctattttt ttgacagtta cgtatagttt cagtaagttt 56700 tgattgttgt attcctgtat ctctagataa gttagtcata tagtcccttc cggcgatacg 56760 ttttttccaa gcccgaaatt gattagccaa atgtgtattt atttttgtga tattgatata 56820 atatgtaatg ttattaatat ttcggataat gcatactgtt agtc ttatat catttggttc 56880 atctatgtat tgtaatattg ttacatgatc tatagatgat gtattgattt tggcaggatc 56940 gaattccata tccgcgacta aacagtgaaa aaaatgtaaa tactttttaa attttaaatt 57000 agtaaaactt ttttttattt tttatgattc caaaaatact gaatacaaag tcctaaatta 57060 taaatatgga gatcatacta ccacaactta ttattatgca tactcagccg gtgtaataga 57120 tagatatata taattctatt acaccggcag acaattaccg atcggtattt gtcgttacca 57180 acataccgta taatatgtaa tatacaattc cataacccat tgacagttgt tatacatcaa 57240 aattgcaatt cttttgatta cgatgttata agaatgtagt taattgatgt atgatgttaa 57300 tgtgtcctct ttcctcttat aacatcgtaa tcaaaaactt ttttataata tatacctaat 57360 aatgtgtctt aatagttctc gtgattcgtc aaacaatcat tcttataaaa tataataaag 57420 caacgtaaaa cacataaaaa taagcgtaac taataagaca atggatattt acgacgataa 57480 aggtctacag actattaaac tgtttaataa tgaatttgat tgtataagga atgacatcag 57540 agaattattt aaacatgtaa ctgattccga tagtatacaa cttccgatgg aagacaattc 57600 tgatattata gaaaatatca gaaaaatact atatagacga ttaaaaaatg tagaatgtgt 57660 tgacatcgat agtacaataa cttttatgaa atacgat cca aatgatgata ataagcgtac 57720 gtgttctaat tgggtaccct taactaataa ctatatggaa tattgtctag taatatattt 57780 ggaaacaccg atatgtggag gcaaaataaa attataccac cctacaggaa atataaagtc 57840 ggataaggat attatgtttg caaagactct agactttaaa tcaaagaaag tgttaactgg 57900 acgtaaaaca attgccgttc tagacatatc cgtttcatat aatagatcaa tgactactat 57960 tcactacaac gacgacgttg atatagatat acatactgat aaaaatggaa aagagttatg 58020 ttattgttat ataacaatag atgatcatta cttggttgat gtggaaacta taggagttat 58080 agtcaataga tctggaaaat gtctgttagt aaataaccat ctaggtatag gtatcgttaa 58140 agataaacgt ataagcgata gttttggaga tgtatgtatg gatacaatat ttgacttttc 58200 tgaagcacga gagttatttt cattaactaa tgatgataac aggaatatag catgggacac 58260 tgataaacta gacgatgata cagatatatg gactcccgtc acagaagatg attacaaatt 58320 tctttctaga ctagtattgt atgcaaaatc tcaatcggat actgtattcg actattatgt 58380 tcttactggt gatacggaac cacccactgt attcattttc aaggtaacta gattttactt 58440 taatatgccg aaataaaaaa tttttgtata atatctagag gtagaggtat tgtttagata 58500 aatacaaata acatagatac atcgcatact tagcattttt ataaatatac ataagacata 58560 cactttatac attttttttg taaaaatact cataaaaaaa tttataaaaa ttatggcaca 58620 accatatctt gtataggtag tttagttcgt cgagtgaacc tataaacaga taatagacaa 58680 cacgtaataa taataatgcc tactaataca agcataatac cgggagatgg gatatatgac 58740 gttgtagtgt ttgggttttc tgaacgttga tagtctacta atactacatg ctgacatcta 58800 atgcctgtat aaccatgaga gcatctacaa tacataccgt caatatctct agcgtggata 58860 cagtcaccgt gtaaacaata tccatctccc tctggaccgc ataatctgat agctggaata 58920 tctgttgtag cgtttgtaat ttctggcgat gtcgtttcga tagcgttacc actatcggcg 58980 aatgatctga ttatcatagc agcgaacaac aacatcagat atttcatcga catttttgat 59040 ggattttgtg tttatgctgt ttctcagtgt gtgtttatga caagattggg aattttatat 59100 tattaattca gtaatataaa ctaataatat attgttaatt gtgtaaataa tataaaaata 59160 acaatacaat attgaatgtg ttgctgttaa aaatgatcat aaacacggag tttattttat 59220 atgtctcgca taaacattac taaaaaaata tattgttctg tttttctttc acatctttaa 59280 ttatgaaaaa gtaaatcatt atgagatgga cgagattgta cgcatcgttc gcgacagtat 59340 gtggtacata cctaacgtat tt atggacga cggtaagaat gaaggtcacg tttctgtcaa 59400 caatgtctgt catatgtatt tcacgttctt tgatgtggat acatcgtctc atctgtttaa 59460 gctagttatt aaacactgcg atctgaataa acgaggtaac tctccattac attgctatac 59520 gatgaataca cgatttaatc catctgtatt aaagatattg ttacaccacg gcatgcgtaa 59580 ctttgatagc aaggatgaaa aaggacacca ctatcaatcg ataacaagat ctttgatata 59640 ctaacggaca ccattgatga ctttagtaaa tcatccgatc tattgctgtg ttatcttaga 59700 tataaattca atgggagctt aaactattac gttctgtaca aaggatccga cgaggatgaa 59760 ctcacttctc ttcattacta ctgtaaacac atatccacgt tctacaaaag caattattac 59820 aagttaagtc acactaagat gcgagccgag aagcgattca tctacgcgat aatagattat 59880 ggagcaaaca ttaacgcggt tacacactta ccttcaacag tataccaaac atagtcctcg 59940 tgtggtgtat gctcttttat ctcgaggagc cgatacgagg atacgtaata atcttgattg 60000 tacacccatc atggaacgat tgtgcaacag gtcatattct cataatgtta ctcaattggc 60060 acgaacaaaa ggaagaagga caacatctac tttatctatt cataaaacat aatcaaggat 60120 acactctcaa tatactacgg tatctactag ataggttcga cattcagaaa gacgaatact 60180 ataataccgc ctttc aaaat tgtaacaaca atgttgcctc atacatcgga tacgacatca 60240 accttccgac taaagacggt attcgacttg gtgtttgaaa acagaaacat catatacaag 60300 gcggatgttg tgaatgacat catccaccac agactgaaag tatctctacc tatgattaaa 60360 tcgttgttct acaagatgtc tctccctacg acgattacta cgtaaagaag ataatagcct 60420 actgcctatt aagggacgag tcattcgcgg aactacatag taaattctgt ttaaacgagg 60480 actataaaag tgtatttatg aaaaatatat cattcgataa gatagattcc atcatcgtga 60540 cataagtcgc cttaaagaga ttcgaatctc cgacaccgac ctgtatacgg tatcacagct 60600 atcttaaagc catacattca gacagtcaca tttcatttcc catgtacgac gatctcatag 60660 aacagtgcca tctatcgatg gagcgtaaaa gtaaactcgt cgacaaagca ctcaataaat 60720 tagagtctac catcggtcaa tctagactat cgtatttgcc tccggaaatt atgcgcaata 60780 tcatctaaac agtatgttgt acgaaaagaa ccattacaaa tattatccat gatagaaaga 60840 aaatatctat atgattggag aagtaggaaa caggaacaag acgacgatta ctacattatt 60900 aaatcatgaa gtccgtatta tactcgtata tattgtttct ctcatgtata ataataaacg 60960 gaagagatat agcaccgcat gcaccatccg atggaaagtg taaagacaac gaatacaaac 61020 gccataat tt gtgtccggga acatacgctt ccagattatg cgatagcaag actaacacac 61080 aatgtacgcc gtgtggttcg ggtaccttca catctcgcaa taatcattta cccgcttgtc 61140 taagttgtaa cggaagacgc gaccgtgtaa cacgactcac aatagaatct gtgaatgctc 61200 tcccggatat tattgtcttc tcaaaggatc atccggatgc aaggcatgtg tttcccaaac 61260 aaaatgtgga ataggatacg gagtatccgg agacgtcatc tgttctccgt gtggtctcgg 61320 aacatattct cacaccgtct cttccgcaga taaatgcgaa cccgtaccca gtaatacctt 61380 taactatatc gatgtggaaa ttaatctgta tccagttaac gaccactacc ggtctcagcg 61440 aatccatctc aacgtcggaa ctaactatta ctatgaatca taaagactgt aatcccgtat 61500 ttcgtgagga atacttctcc gtccttaata aggtagcaac ttcaggtttc tttacaggag 61560 aaaggtgtgc actctgaatt tcgagattaa atgcaataac aaaaattttt cctccaaaca 61620 gttaacgaaa gcaaagaatg atgacggtat catgccgcat tcggagactg tctatctagc 61680 gtcgacatct atatactata tagtaatacc aatactcaag actacgaaac tgatacaatc 61740 tcttatcatg tgggtaatgt tctcgatgtc gatagccata tgcccggtag ttgcgatata 61800 cataaactga tcactaattc caaacccacc cgctttttat agtaagtttt tcacccataa 61860 ataataaata caataattaa tttctcgtaa aagtagaaaa tatattctaa tttattgcac 61920 ggtaaggaag tagaatcata aagaacagta ctcaatcaat agcaatcatg aaacaatata 61980 tcgtcctggc atgcatgtgc ctgccagtct tcagcaatca tcctcatcct cctcctcgtg 62040 tacggaagaa gaaaacaaac atcatatggg aatcgatgtt attatcaaag tcacaaagca 62100 agaccaaaca ccgaccaatg ataagatttg ccaatccgta acggaaatta cagagtccga 62160 gtcagatcca gatcccgagg tggaatcaga agatgattcc acatcagtcg aggatgtaga 62220 tcctcctacc acttattact ccatcatcgg tggaggtctg agaatgaact ttggattcac 62280 caaatgtcct cagattaaat ccatctcaga atccgctgat ggaaacacag tgaatgctag 62340 attgtccagc gtgtccccag gacaaggtaa ggactctccc gcgatcactc atgaagaagc 62400 tctggctatg atcaaagact gtgaggtgtc tatcgacatc agatgtagcg aagaagagaa 62460 agacagcgac atcaagaccc atccagtact cgggtctaac atctctcata agaaagtgag 62520 ttacgaagat atcatcggtt caacgatcgt cgatacaaaa tgtgtcaaga atctagagtt 62580 tagcgttcgt atcggagaca tgtgcaagga atcatctgaa cttgaggtca aggatggatt 62640 taagtatgtc gacggatcgg catctgaagg tgcaaccgat gatacttcac tcatcgatt c 62700 aacaaaactc aaagcgtgtg tctgaatcga taactctatt catctgaaat tggatgagta 62760 gggttaatcg aacgattcag gcacaccacg aattaaaaaa gtgtaccgga cactatattc 62820 cggtttgcaa aacaaaaatg ttcttaacta cattcacaaa aagttacctc tcgcgacttc 62880 ttctttttct gtctcaatag tgtgatacga ttatgacact attcctattc ctattcctat 62940 ttcctttcag ggtatcacaa aaatattaaa cctctttctg atggtctcat aaaaaaagtt 63000 ttacaaaaat atttttattc tctttctctc tttgatggtc tcataaaaaa agttttacaa 63060 aaatattttt attctctttc tctctttgat ggtctcataa aaaaagtttt acaaaaatat 63120 ttttattctc tttctctctt tgatggtctc ataaaaaaag ttttacaaaa atatttttat 63180 tctctttctc tctttgatgg tctcataaaa aaagttttac aaaaatattt ttattctctt 63240 tctctctttg atggtctcat aaaaaaagtt ttacaaaaat atttttattc tctttctctc 63300 tttgatggtc tcataaaaaa agttttacaa aaatattttt attctctttc tctctttgat 63360 ggtctcataa aaaaagtttt acaaaaatat ttttattctc tttctctctt tgatggtctc 63420 ataaaaaata ttaaacctct ttctgatggt gtcactaaaa tatttttatt ctcattctca 63480 ttttctcttt ctctcttcaa tggagtcata aaatattttt attctctttc t ctcttcgat 63540 ggtctcacaa aaatattaaa cctctttctg atggtgtcac taaaatattt ttattctcat 63600 tctcattttc tctttctctc ttcaatggag tcataaaata tttttattct ctttctctct 63660 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 63720 ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 63780 agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga 63840 gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct 63900 ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata 63960 ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct 64020 cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 64080 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 64140 ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 64200 agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga 64260 gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct 64320 ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcga tggtct cacaaaaata 64380 ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct 64440 cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 64500 tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct 64560 ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa 64620 agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct ttctgatgga 64680 gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata ttaaacctct 64740 ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct cacaaaaata 64800 ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct tcgatggtct 64860 cacaaaaata ttaaacctct ttctgatgga gtcgtaaaaa agttttatct ctttctctct 64920 tcgatggtct cactaaaata ttttttattc tctttctgat gcatcaacta tttcttaaac 64980 aataacgtcc aacaacatat actcgtcgag cttatcaaca tcccctatgc ccatctaggt 65040 taccagacaa ttgtatatca taaaataatg tttataattt acacgttaaa atcatataat 65100 aaaacgtaga tcgtataata ttttttggta tataaatgat ctagtaaaat ccatgtaggg 65160 gatactgctc acattttttc tttggtacaa aatttca cac aagtttttat acagacaaat 65220 tcttgtccat atattttaaa acattgactt ttgtactaag aaaaatatct agatcaacta 65280 tctctttctc tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatggag 65340 tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat taaacctctt 65400 tctgatggag tcgtaaaaaa gttttatctc tttctctctt cgatggtctc acaaaaatat 65460 taaacctctt tctgatggag tcgtaaaaaa gttttatctc tttctctctt cgatggtctc 65520 acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc tttctctctt 65580 cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa gttttatctc 65640 tttctctctt cgatggtctc acaaaaatat taaacctctt tctgatggag tcgtaaaaaa 65700 gttttatctc tttctccttc gatggtctca caaaaatatt aaacctcttt ctgatggagt 65760 cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt aaacctcttt 65820 ctgatggagt cgtaaaaaag ttttatctct ttctctcttc gatggtctca caaaaatatt 65880 aaacctcttt ctgatggagt cgtaaaaaag ttttatctct ttctccttcg atggtctcac 65940 aaaaatatta aacctctttc tgatggagtc gtaaaaaagt tttatctctt tctccttcga 66000 tggtctcaca aaaatattaa acctctttct gatggagtcg taaaaaagtt ttatctcttt 66060 ctctcttcga tggtctcaca aaaatattaa acctctttct gatggagtcg taaaaaagtt 66120 ttatctcttt ctctcttcga tggtctcaca aaaatattaa acctctttct gatggtctct 66180 ataaagcgat cgatctttct tacactctag agtttcctac agtcatgggt cacacatttt 66240 tttctagaca ctaaataaaa tatttaaaat ataatattaa tgtactaaaa cttatatatt 66300 attaatttat ctaactaaag ttagtaaatt atatatataa ttttataatt aatttaattt 66360tactaatttt atttagtgtc tagaaaaaaa 66390

Claims (42)

A method for producing a poxvirus vector or a recombinant poxvirus vector comprising the steps of:
transfecting the one or more DNA fragments into a host cell, wherein the one or more DNA fragments comprise the entire genomic DNA sequence of a poxvirus for which the poxvirus is desired to be reconstituted in the host cell. The full-length poxvirus genome of claim 1 , wherein the two or more DNA fragments are co-transfected into a host cell, each DNA fragment being assembled by homologous recombination when the two or more DNA fragments are reconstituted in the host cell. and a partial sequence of the poxvirus genome to include the sequence. 3. The method of claim 1 or 2, further comprising the step of infecting a host cell with a helper virus prior to, during, or after transfection of the one or more DNA fragments to initiate transcription of the one or more DNA fragments. 4. The method of claim 3, wherein the helper virus is fowlpox virus (FPV), sheep fibroma virus, vaccinia virus, or vaccinia virus. 5. The method according to any one of claims 1 to 4, wherein the one or more DNA fragments are either circularized prior to transfection or are transfected into the host cell in circular form. 6. The method of claim 5, wherein the one or more DNA fragments are cloned into a plasmid or a bacterial artificial chromosome (BAC) vector. 5. The method according to any one of claims 1 to 4, wherein the one or more DNA fragments are linearized or transfected into the host cell in a linearized form prior to co-transfection. 8. The method according to any one of claims 1 to 7, wherein the one or more DNA fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments. 9. The method according to any one of claims 1 to 8, wherein the poxvirus genome sequence comprises the sequence of modified Vaccinia Ankara (MVA) accession number #U94848 or #AY603355. 10. The method according to any one of claims 1 to 9, wherein the two adjacent DNA fragments have overlapping sequences that facilitate homologous recombination. The method of claim 10 , wherein the overlapping sequence is from about 100 bp to about 5000 bp in length. 12. The method of any one of claims 1-11, wherein the at least one DNA fragment further comprises an inverted terminal repeat (ITR) region. 13. The method of any one of claims 1-12, wherein the at least one DNA fragment further comprises a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genomic degradation (CR) sequence, or both, wherein the HL or CR wherein the sequence is added to one or both ends of the DNA fragment as a single-stranded or double-stranded DNA sequence in sense or antisense orientation. 14. The method of claim 13, wherein the at least one DNA fragment further comprises at least one HL sequence and at least one CR sequence. 15. The method of claim 14, wherein each HL sequence is flanked by two CR sequences at both ends of the HL sequence. 16. The method of any one of claims 13-15, wherein only a subset of the at least one DNA fragment comprises an HL or CR sequence. 17. The method of any one of claims 1 to 16, wherein the one or more DNA fragments further comprise one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof. 18. The method of claim 17, wherein the two or more DNA fragments comprise DNA sequences of the same antigen, subunits or fragments thereof, or identical heterologous DNA sequences. 18. The method of claim 17, wherein the at least two DNA fragments comprise DNA sequences of different antigens, subunits or fragments thereof, or other heterologous DNA sequences. 20. The method according to any one of claims 17 to 19, wherein the DNA sequence or other heterologous DNA sequence of the antigen, subunit or fragment thereof is codon optimized for expression in the host cell. 21. The method according to any one of claims 17 to 20, wherein the at least one DNA fragment comprises a DNA sequence of an antigen, a subunit or fragment thereof or another heterologous DNA sequence upstream of a viral promoter, a DNA sequence of an antigen, a subunit or fragment thereof, or further comprising another heterologous DNA sequence transcription termination signal downstream, or both. 22. The method according to any one of claims 17 to 21, wherein the DNA sequence encoding the antigen, subunit or fragment thereof or other heterologous DNA sequence is inserted at one or more poxvirus insertion sites or intergenic regions. An expression system comprising:
(i) a single DNA fragment comprising the entire genome of the poxvirus of interest, or two or more DNA fragments, when expressed in a host cell upon co-transfection, assemble sequentially to contain the full-length sequence of the poxvirus genome; two or more DNA fragments each comprising a partial sequence of the genome of the desired poxvirus to enable reconstitution of the desired recombinant poxvirus, and
(ii) one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof inserted into one or more insertion sites of a poxvirus, wherein the antigen or subunits thereof or other heterologous DNA sequences comprise one or more A DNA sequence expressed in a host cell upon transfection of the poxvirus DNA fragment and reconstitution of the poxvirus. 24. The expression system of claim 23, wherein the one or more DNA fragments are circularized prior to transfection or are transfected into the host cell in circular form. 25. The expression system of claim 24, wherein the one or more DNA fragments are cloned into a plasmid or BAC vector. 24. The expression system of claim 23, wherein the one or more DNA fragments are linearized prior to transfection or are transfected into the host cell in a linearized form. 27. The expression system of any one of claims 23 to 26, wherein the one or more DNA fragments are naturally derived, chemically synthesized, or a combination of naturally derived and chemically synthesized DNA fragments. 28. The expression system according to any one of claims 23 to 27, wherein the genomic sequence of the poxvirus comprises the sequence of MVA accession number #U94848 or #AY603355. 29. The expression system according to any one of claims 23 to 28, wherein the two adjacent DNA fragments have overlapping sequences that facilitate homologous recombination. 30. The expression system of claim 29, wherein the overlapping sequence is from about 100 bp to about 5000 bp in length. 31. The expression system of any one of claims 23-30, wherein the at least one DNA fragment further comprises an inverted terminal repeat (ITR) region. 32. The method of any one of claims 23-31, wherein the one or more DNA fragments further comprise a poxvirus terminal hairpin loop (HL) sequence, a poxvirus genomic degradation (CR) sequence, or both, wherein the HL or CR wherein the sequence is appended to one or both ends of the DNA fragment as a single-stranded or double-stranded DNA sequence in sense or antisense orientation. 33. The expression system of claim 32, wherein the at least one DNA fragment further comprises at least one HL sequence and at least one CR sequence. 34. The expression system of claim 33, wherein each HL sequence is flanked by two CR sequences at both ends of the HL sequence. 35. The expression system of any one of claims 32-34, wherein only a subset of the at least one DNA fragment comprises an HL or CR sequence. 36. The method according to any one of claims 23 to 35, wherein the at least one DNA fragment encodes a DNA sequence encoding an antigen, a subunit or fragment thereof or another heterologous DNA sequence upstream of a viral promoter, encoding an antigen, a subunit or fragment thereof wherein the expression system further comprises a transcription termination signal downstream of the DNA sequence or other heterologous DNA sequence, or both. 37. The expression system according to any one of claims 23 to 36, wherein a DNA sequence or other heterologous DNA sequence encoding one or more antigens, subunits or fragments thereof is inserted at one or more poxvirus insertion sites. A vaccine composition for preventing or treating cancer or viral infection, comprising:
(i) a single DNA fragment comprising the entire genome of the poxvirus of interest, or two or more DNA fragments, when delivered to a host cell upon co-transfection, assemble sequentially to contain the full-length sequence of the poxvirus genome; two or more DNA fragments each comprising a partial sequence of the genome of the poxvirus of interest, and
(ii) one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof inserted into one or more insertion sites of a poxvirus, wherein the antigen, subunits or fragments thereof or other heterologous DNA sequences are A DNA sequence that is expressed in a host cell upon transfection of one or more poxvirus DNA fragments. 39. The vaccine composition of claim 38, wherein the antigen, subunit or fragment thereof or other heterologous DNA sequence is inserted at one or more poxvirus insertion sites. 40. The vaccine composition of claim 38 or 39, further comprising a pharmaceutically acceptable carrier, adjuvant, excipient or combination thereof. A method of preventing or treating cancer or a viral infection in a subject comprising administering to the subject a prophylactically or therapeutically effective amount of a vaccine composition, wherein the vaccine comprises:
(i) a single DNA fragment comprising the entire genome of the poxvirus of interest, or two or more DNA fragments, when delivered to a host cell upon co-transfection, assemble sequentially to contain the full-length sequence of the poxvirus genome; two or more DNA fragments each comprising a partial sequence of the genome of the poxvirus of interest, and
(ii) one or more DNA sequences or other heterologous DNA sequences encoding one or more antigens, subunits or fragments thereof inserted into one or more insertion sites of a poxvirus, wherein the antigen, subunits or fragments thereof or other heterologous DNA sequences are A DNA sequence that is expressed in a host cell upon transfection of one or more poxvirus DNA fragments. 42. The method of claim 41, wherein the antigen, subunit or fragment thereof or other heterologous DNA sequence is inserted at one or more poxvirus insertion sites.

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