KR20210006600A - Bone cement composition for periodontal tissue - Google Patents

Abstract

The present invention relates to a bone cement composition for periodontal use, comprising: calcium phosphate; calcium sulfate; calcium carbonate (CaCO_3); silicon dioxide (SiO_2); aluminum oxide; and calcium zirconia complexes. According to the present invention, since an implanted tooth can be stably fixed within a few days, discomfort due to dental implantation can be minimized, and the success rate of dental implantation can be increased.

Description

Bone cement composition for periodontal tissue

The present invention relates to a bone cement composition for periodontal, and more particularly, to a bone cement composition for periodontal that can stably perform autoimplantation, reimplantation with a high success rate.

The self-toothed eye type is a method in which a tooth that is judged to be usable, such as a wisdom tooth or other ambush tooth, is transferred to the missing area to obtain healing and function. In particular, wisdom teeth are used a lot here, and since teeth are removed and transferred, teeth undergoing autotransplantation lose their vitality, so neurological treatment is required. After transplantation, methods such as orthodontic wire or resin bonding around the implanted tooth The fixation is induced until it is completely attached to the bone for 6-8 weeks. And when it is fixed and stable use is possible, a brass crown should be applied to protect the teeth. This type of self-dental eye type uses one's own teeth, so if it is well managed, it can have many advantages over implants.

In general, when a tooth is defective, the surrounding tooth is removed and then both abutments are connected to form a bridge, which may cause a problem of damaging healthy adjacent teeth. However, dental implantation can avoid damage to healthy adjacent teeth. In recent years, implants are widely used as a method of repairing defective teeth without damaging adjacent teeth, but treatment costs are expensive and treatment periods are also relatively long.

In contrast, the autogenous dental implant is cheaper than implants, has a shorter treatment period, and is transplanted to a site where the alveolar bone is destroyed a lot, thereby inducing alveolar bone formation. After the implanted tooth is fixed, you can feel the same sensation as your own.

In this self-healing method, a tooth is extracted, part of the root of the tooth that causes inflammation is cut off, and the tip of the root is filled with commercially available MTA (Mineral Trioxide Aggregate) and re-inserted. There has been a method of restoring one's original teeth without any treatment.

However, the present inventor's dentistry performed MTA clinical procedures on patients in the same way as the conventional method, but the success rate was very low, and there was a problem that the MTA bone cement melted after the procedure, and when using a commercialized bone cement, Since the implanted tooth can not be used at all for about 6 months after the tooth implantation, there is a problem in that the implantation may fail due to carelessness as well as cause discomfort when eating. Accordingly, there is a need to develop a bone cement material for periodontal that does not melt the bone cement and can stably fix the implanted tooth in a short time, thereby improving the implantation success rate and minimizing the discomfort of the patient.

Korean Patent Registration No. 10-1868873

An object of the present invention is periodontal bone cement used in autogenous dental implantation, which does not melt after the procedure and maintains its shape, and the implanted tooth is stably fixed within a short period of time, allowing a soft meal immediately after the procedure, and only 2 to 3 days later. It is to provide a bone cement composition for periodontal that can enable normal eating.

According to one aspect of the invention,

Calcium phosphate; Gypsum (calcium sulfate); Calcium carbonate (CaCO ₃ ); Silicon dioxide (SiO ₂ ); Aluminum oxide; And calcium zirconia complex; periodontal bone cement composition comprising a is provided.

Preferably, the periodontal bone cement composition.

Based on 100 parts by weight of calcium phosphate, 30 to 40 parts by weight of gypsum (calcium sulfate); Calcium carbonate (CaCO ₃ ) 9 to 12 parts by weight; Silicon dioxide (SiO ₂ ) 0.5 to 2.5 parts by weight; 0.5 to 1.5 parts by weight of aluminum oxide; And 3 to 4.5 parts by weight of the calcium zirconia complex.

The periodontal bone cement composition,

Perphosphoric acid; And distilled water or saline; may further include.

The calcium phosphate may be acidic calcium phosphate or basic calcium phosphate.

The calcium phosphate is β-tricalcium phosphate (β-TCP), dicalcium phosphate dihydrate (CaHPO _{4 ·} · 2H ₂ O, DCPD), tetracalcium dihydrogen phosphate (Ca ₄ H ₂ P ₆ O ₂₀ , TCHP) , Hydroxyapatite (HAp), octacalcium phosphate (OCP), α-tricalcium phosphate (α-TCP), and tetra calcium phosphate (TTCP).

The calcium phosphate may be β-tricalcium phosphate (β-TCP).

The gypsum (calcium sulfate) may be at least one selected from hemihydrate gypsum (calcium sulfate hemihydrate), dihydrate gypsum (calcium sulfate dehydrate), and anhydrous gypsum (calcium sulfate anhydrate).

The gypsum (calcium sulfate) may be a hemihydrate gypsum (calcium sulfate hemihydrate).

The periodontal bone cement composition may be used for natural tooth implantation or tooth decay treatment.

The periodontal bone cement composition of the present invention is a periodontal bone cement used in an autogenous tooth formula that does not melt after the procedure and maintains its shape, and the implanted tooth is stably fixed within a short period of time, allowing a soft meal immediately after the procedure. Normal eating can be enabled after to 3 days.

1 to 5 are X-ray panoramic photographs showing the dental implantation treatment process of patient A.
6 to 11 are X-ray panoramic photographs showing the progress of the dental implantation treatment of patient B.
12 to 15 are X-ray panoramic photographs showing the progress of dental implantation treatment of patient C.

Since the present invention can apply various transformations and have various embodiments, specific embodiments will be illustrated in the drawings and described in detail. However, this is not intended to limit the present invention to a specific embodiment, it is to be understood to include all conversions, equivalents, and substitutes included in the spirit and scope of the present invention. In describing the present invention, when it is determined that a detailed description of a related known technology may obscure the subject matter of the present invention, a detailed description thereof will be omitted.

Hereinafter, the bone cement composition for periodontal of the present invention will be described.

The bone cement composition for periodontal of the present invention includes calcium phosphate; Gypsum (calcium sulfate); Calcium carbonate (CaCO ₃ ); Silicon dioxide (SiO ₂ ); Aluminum oxide; And a calcium zirconia complex.

Preferably, the periodontal bone cement composition is based on 100 parts by weight of calcium phosphate, 30 to 40 parts by weight of gypsum (calcium sulfate); Calcium carbonate (CaCO ₃ ) 9 to 12 parts by weight; Silicon dioxide (SiO ₂ ) 0.5 to 2.5 parts by weight; 0.5 to 1.5 parts by weight of aluminum oxide; And 3 to 4.5 parts by weight of the calcium zirconia complex.

The periodontal bone cement composition may include perphosphoric acid as a liquid component; And distilled water or saline; may further include.

The calcium phosphate may be acidic calcium phosphate or basic calcium phosphate.

Specifically, the calcium phosphate is β- tricalcium phosphate (β-TCP), dicalcium phosphate dihydrate _{(CaHPO 4 · · 2H 2 O} , DCPD), tetra-calcium dihydrogen phosphate _{(Ca 4 H 2 P 6 O} 20 , TCHP), hydroxyapatite (HAp), octacalcium phosphate (OCP), α-tricalcium phosphate (α-TCP) and tetra calcium phosphate (TTCP), but may be at least one selected from, β-tricalcium phosphate (β -TCP) is preferred.

As a commercial product containing calcium phosphate, it is preferable to use a synthetic bone product "Vital" of RENEW Medical, but the scope of the present invention is not limited thereto.

The calcium phosphate may change in phase equilibrium according to various pH conditions due to a reaction with phosphoric acid and a supersaturated concentration of calcium that changes depending on the pH condition.

Specifically, the calcium phosphate is the most stable phase of dicalcium phosphate dihydrate (CaHPO _{4 ·} · 2H ₂ O, DCPD) at a pH of 4.2 or less, and hydroxyapatite (HAp) is the most stable at a pH of 5.5 or more. It is stable and is formed in the largest amount, and in the range of pH 4.2 to 4.8, β-tricalcium phosphate (β-TCP), hydroxy apatite (Hap), octacalcium phosphate (OCP), α-tricalcium phosphate (α-TCP) And a mixed phase of tetra calcium phosphate (TTCP) is formed. In addition, when the pH environment is in the range of 4.8 to 5.5, a large amount of β-TCP is formed, which is supersaturated and then precipitated. This pH range can be set by adjusting the amount of phosphoric acid to be added, but in a mass-scaled process, this can be easily implemented with a manual dose.

Mixing of an aqueous calcium solution and an aqueous phosphoric acid solution causes an exothermic reaction. Although the present invention can be practiced without using an additional temperature forming device, it is preferable to maintain a temperature environment of 20 to 125°C in order to obtain β-TCP as a moderate environment, and more preferably 60 to 95°C. Maintaining the temperature condition is advantageous in terms of solubility, reaction and yield of precipitation. That is, when the temperature environment exceeds 125°C, the solubility of the β-TCP to be formed is too high, making it difficult to obtain satisfactory levels, and at temperatures below 20°C, it is difficult to sufficiently react the aqueous calcium solution with phosphoric acid. Through these results and several additional tests, an optimum yield can be achieved at a temperature of 60 to 95°C.

In addition, the aqueous calcium solution used in the reaction may be a solution in which calcium ions are supersaturated depending on the pH and temperature environment. The expression “supersaturated” means that the solute has been added in excess of the limit amount that can be dissolved in the aqueous solution, as in the ordinary technical knowledge in the art. The supersaturated calcium ions may react with phosphate ions to precipitate a product containing β-TCP. In the above-described pH or temperature environment (20 to 125°C), the concentration of dissolved and supersaturated calcium ions may be 7 to 10 mM, and in a more preferable range (temperature environment 60 to 95°C), it may be 7.8 to 10 mM. .

In addition, the reaction is preferably carried out in a carbon dioxide-free atmosphere in which contact with carbon dioxide is blocked. Ca ^{2 +} or Ca compound has the property of reacting easily with CO ₂ in the surrounding environment, because the carbonic acid produced by this acts as a factor that interferes with the crystallization of β-TCP to be formed later. Therefore, those who want to implement or reproduce the present invention, it is preferable to block such an incidental reaction by creating a nitrogen atmosphere or a vacuum environment. An inert gas atmosphere such as Ar may be created, or an N ₂ environment may be set in consideration of cost efficiency and convenience.

The gypsum (calcium sulfate) may be at least one selected from among hemihydrate gypsum (calcium sulfate hemihydrate), dihydrate gypsum (calcium sulfate dehydrate), and anhydrous gypsum (calcium sulfate anhydrate), but it is preferable that hemihydrate (calcium sulfate hemihydrate). .

As a component included in the periodontal bone cement composition of the present invention, calcium carbonate, silicon dioxide, aluminum oxide, and calcium zirconia complex excluding calcium phosphate and gypsum are components included in various commercially available MTA (Mineral Trioxide Aggregate), so MTA By including the bone cement composition for periodontal of the present invention can be easily prepared.

The MTA is a hydraulic bioceramic material. As the MTA used in the present invention, various MTAs distributed on the market may be used, and preferably, “Retro MTA” of BioMTA or “ProRoot MTA” of Dentsply Sirona may be used, but the scope of the present invention is not limited thereto. .

In particular, “Retro MTA” or “ProRoot MTA” is not a cement refined from Portland cement, but is produced by a hydraulic cement manufacturing process. It does not contain heavy metals harmful to the human body, has a fast curing time, and can maintain an appropriate viscosity during hydration. It's easy.

Table 1 below summarizes the physical characteristics of “Retro MTA” or “ProRoot MTA”.

Properties Retro MTA ProRoot MTA Surface area (m ² /kg) 961 409 Average particle diameter (㎛) 2.62 6.9 90wt% finer than(㎛) 4.64 19.97 50wt% finer than (㎛) 2.36 6.85 10wt% finer than (㎛) 1.18 0.97 Coagulation time (start) 180 seconds 74 minutes Coagulation time (termination) 360 minutes 210 minutes Free CaO content (wt%) 0.66 1.74 Total crystalline phases 96.9 94.3 Expansion coefficient 0.09 0.27 color white Yellow & Gray heavy metal none Cr, As, Ni

Table 2 summarizes the components of the preferred MTA that can be included in the bone cement composition of the present invention.

Chemical composition Content (wt%) Calcium carbonate (CaCO ₃ ) 60-80 Silicon dioxide (SiO ₂ ) 5-15 Aluminum oxide 5-10 Calcium zirconia complex 20-30 sum 100

The TMA may be one or more selected from WMTA (White Mineral Trioxide Aggregate), GMTA (Gray Mineral Trioxide Aggregate), and YMTA (Yellow Mineral Trioxide Aggregate), preferably WMTA. This is because the particle size of WMTA is generally more uniform than that of GMTA.

The bone cement composition for periodontal of the present invention may be used for natural tooth implantation or tooth decay treatment.

Hereinafter, the present invention will be described in more detail with reference to preferred embodiments. However, these examples are for describing the present invention in more detail, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited thereto.

[ Example ]

Manufacturing example One: Periodontal Cement composition ( GEMMA ) Produce

A cement composition GEMMA for periodontal consisting of a powder component and a liquid component having the following composition was prepared.

Powder ingredient

β-TCP (β-tricalcium phosphate) 6.8 g,

CSH (calcium sulfate hemihydrate) 2.4 g,

BioMTA's Retro MTA 0.8 g

Liquid ingredient

0.001392 g superphosphate

saline 1 cc

Manufacturing Comparative Example One: VITAL

It is a synthetic bone product of RENEW Medical that is completely decomposed and absorbed after 5 to 6 months. The composition is as follows.

Powder ingredient

β-tricalcium phosphate (β-TCP)

Calcium Sulphate

Liquid ingredient

Saline + HPMC (Hydroxypropyl Methylcellulose)

Manufacturing Comparative Example 2: POLYBONE

We prepared a powder type of POLYBONE, SK Bioland's goal substitute.

Powder ingredient

β-TCP (β-tricalcium phosphate) 6.8 g,

CSH (calcium sulfate hemihydrate) 2.4 g,

MCPM (Monocalcium phosphate monohydrate) 0.8 g

Liquid ingredient

Poly-P (polyphosphoric acid) 0.001392 g

1 cc of distilled water

Example One: GEMMA Tooth transplantation

First, the patient's shaking teeth were extracted and immersed in sodium hypochlorite (NaOCl) solution for 2 to 4 hours to remove gingival and calculus, and then washed with Cavitron. The cleaned tooth extraction was prepared so that it could be re-implanted by sealing it with a dental resin by 2 to 3 mm from the entrance of the apical foramen, which is the tip of the tooth root.

Two weeks after tooth extraction, the patient's inflammation is alleviated, the gums heal, and the periodontal bone is restored. Thereafter, when the tooth extraction portion of the gum was covered, the extracted portion was incised and scraped to secure a hole for transplanting the extracted tooth, and sterilized with a hemostatic agent.

Thereafter, 1 g of the powder component of GEMMA of Preparation Example 1 and 0.6 cc of the liquid component were mixed and hydrated for 1 minute, and then the periodontal cement composition from which moisture was removed was filled in the tooth extraction position, that is, the tooth extraction area, and the filled periodontal cement composition The prepared tooth extraction was implanted. After the implantation, the cement composition for periodontal was hardened by holding for about 5 minutes to fix the implanted tooth.

Immediately after treatment, a soft meal such as porridge was possible, the teeth were fixed within 2 to 3 days, and a general meal was possible, and it was confirmed whether the teeth were successfully fixed after 6 months.

Comparative example One: VITAL Tooth implantation

Tooth implantation was performed in the same manner as in Example 1, except that the VITAL product was used instead of the GEMMA of Example 1. At this time, the use of treatment teeth was prohibited for 6 months after transplantation, and it was confirmed whether the teeth were successfully fixed after 6 months.

Comparative example 2: POLYBONE Tooth implantation

Tooth implantation was performed in the same manner as in Example 1, except that the POLYBONE product was used instead of GEMMA of Example 1. At this time. In the early stages of transplantation, a soft meal such as porridge was made, and after 2 months, a meal with fish and kimchi, etc. could be eaten, and after 3 months, the consumption of tough meat was allowed.

[ Test example ]

Experimental example 1: Analysis of success rate of tooth transplantation

In order to compare the success rate of tooth transplantation in the tooth transplantation performed according to Example 1, Comparative Example 1 and Comparative Example 2, the first tooth transplantation and the second tooth transplantation and the second tooth transplantation were performed in the same manner when the first tooth transplantation failed. In the case of this failure, the number of tooth transplant patients who underwent the third tooth transplant and the final tooth transplant success rate were compared, and the results are shown in Table 3 below.

Item Example 1 (GEMMA) Comparative Example 1 (VITAL) Comparative Example 2 (POLYBONE) Number of first tooth transplant patients 39 42 27 Number of patients with successful first tooth transplant 19 21 0 The number of patients with successful secondary dental transplantation 13 2 2 Number of patients with successful 3rd tooth transplantation 3 One 0 Total number of patients with successful tooth transplantation 35 24 2 Total number of patients with tooth transplant failure 4 18 25 Success rate of tooth transplantation (%) 89.7 57.1 7.4

According to this, in the case of performing a tooth transplantation using the cement composition GEMMA for periodontal of Example 1, it was found that the number of successful patients was large in the order of 1st> 2nd> 3rd transplantation, and the final dental transplant success rate was 89.7%. Was found to have succeeded in tooth transplantation. In addition, GEMMA of Example 1 is capable of normal meals within 2 to 3 days after the tooth transplantation procedure, so compared to the VITAL of Comparative Example 1 and the Polybone of Comparative Example 2, which took several months to fix the teeth, In addition to minimization, it is possible to minimize the risk of tooth implant failure due to accidental impact during the tooth fixation period.

On the other hand, the tooth transplantation using VITAL of Comparative Example 1 had a high initial transplant success rate of 50%, but the success rate was very low in the 2nd to 3rd tooth transplantation after failure. And although the final success rate was not as low as 57.1%, the final success rate was significantly lower than that of GEMMA of Example 1. In addition, the VITAL of Comparative Example 1 has a disadvantage that the implantation teeth cannot be used for 6 months after the tooth implantation, so the inconvenience of the patient being treated is large, and there is a high risk of the tooth implantation failure due to careless impact due to the long tooth fixation and bone regeneration period. .

In addition, in the case of the tooth transplantation using the Polybone of Comparative Example 2, it was very difficult to fix the tooth, so the success rate of the tooth transplantation was only 7.4%.It was found that the roots did not stick to the jaw bone after 5 to 6 months after the procedure, so as a cement for periodontal use It can be confirmed that it is not suitable.

Test example 2: Patient A's tooth implant Clinical example

Panoramic images of X-rays taken at each time of patient A who successfully transplanted from the GEMMA treatment group of Example 1 are shown in Figs. 1 to 5, and the treatment process and tooth condition are described below.

2018. 8. 13

(A) of FIG. 1 is an X-ray panoramic picture of the dental condition of patient A, and (b) is an enlarged view of a portion of the right first molar indicated in yellow.

The upper right first molar was violently shaken, complaining of discomfort, and appeared black because there were no bones surrounding the teeth on the panorama.

Aug 16, 2018

Root removal curettage was performed to relieve inflammation of the surrounding teeth.

September 7, 2018

2(a) shows the right first molar part as an X-ray panoramic picture of patient A's tooth after inflammation relief, and the display part of (b) shows that the right condyle of the patient is normal.

2018. 9. 20

The tooth was extracted for intentional replantation, and the tooth was immersed in NaOCl for 3 hours to remove the endotoxin leached from the tartar and the root, and stored in Saline for 2 weeks.

3(a) is an X-ray panoramic picture of the tooth of patient A before extraction, and (b) is an enlarged portion of the tooth extraction, and this picture is a left and right inverted image.

October 5, 2018

The tooth tooth was incised, hemostated after the sofa, and the Gemma according to Preparation Example 1 was applied to the root surface of the tooth, embedded in the tooth tooth, and the bridge was fixed together with the side teeth.

Figure 4 (a) is an X-ray image of the same area on August 13, 2018 at the time of first visit, after a tooth implantation procedure using GEMMA on October 5, 2018.

After the procedure, he ate a soft meal with porridge immediately, and two days later, normal meals were available.

November 19, 2018

Figure 5 (a) is a dental implantation state using GEMMA on November 19, 2018, and (b) is an X-ray image of the same portion on August 13, 2018 at the time of first visit.

The kimchi stew 5 days had elapsed, but there was no percussion reaction and tooth agitation, and according to (a), it was confirmed that the alveolar bone was formed white on the X-ray image.

April 24, 2019

Panoramic photos were taken to confirm a stable bone condition around the root. It was confirmed that the GEMMA-coated treatment area was white and clearly appeared on the X-ray picture, the teeth were fixed stably, and bone regeneration was performed. In addition, there was no difficulty in all meals.

Experimental example 3: Dental implant in patient B Clinical example

6 to 11 are photographs showing the progress of the dental implantation treatment of patient B.

2016.08.17

Patient B was determined to have chronic periodontitis and decided to implant a tooth using the Vital of Comparative Preparation Example 2. After tooth extraction, tooth sterilization and sterilization were performed, and Vital was immediately filled into the tooth extraction and tooth was inserted.

(A) of FIG. 6 is an X-ray picture of the teeth of patient B before being judged for chronic periodontitis on December 20, 2014, and (b) is an X-ray picture of the teeth of patient B immediately after tooth implantation using Vital on August 17, 2016. And (c) is an X-ray picture of the teeth of patient B after 9 days of tooth implantation using Vital on August 26, 2016, comparing the conditions before and after implantation.

November 30, 2017

7 is an X-ray image of the implanted tooth of patient B on November 30, 2017, about 3 months after tooth implantation using Vital. According to this, it was confirmed that the white color became clear on the Vital coating area of the implanted tooth.

May 30, 2018

There was no more than 6 months after tooth implantation using Vital, but patient B complained of pain and shaking of teeth on May 30, 2018.

June 28, 2018

8 is a tooth X-ray photograph of patient B on June 28, 2018. As a result of treatment, it was confirmed that periodontitis recurred.

2018. 12. 13

Dental implantation using Vital was judged to be a failure.

GEMMA procedure was decided, and after extraction, tooth extraction was immersed in NaOCl for 3 hours to remove endotoxin leached from calculus and roots, and stored in Saline for 2 weeks.

December 28, 2019

FIG. 9 is an X-ray photograph of patient B immediately after a re-examination procedure using GEMMA.

After the tooth decay was surgically cured, hemostasis was performed, and after filling GEMMA, the tooth tooth with GEMMA applied to the root surface was directly inserted into the tooth tooth and the teeth were fixed in place. Patient B was able to eat a soft meal made of porridge immediately after the procedure, and the teeth were fixed quickly, so that a regular meal including rice was possible within 3 days.

March 28, 2019

FIG. 10 is an X-ray photograph of a tooth implanted at 28 March 2019, 3 months after the patient B's re-esthetic procedure using GEMMA. About 3 months after the procedure, there was no pain or shaking of teeth, and normal meal was possible.

May 3, 2019

FIG. 11 is an X-ray picture of a tooth implanted in May 3, 2019 after 4 months or more of patient B's re-esthetic procedure using GEMMA. According to this, it was confirmed that the tooth condition was well maintained, bone regeneration was well progressed, and the GEMMA junction was gradually changing from black to white.

Experimental example 4: patient C tooth transplant Clinical example

12 to 15 are photographs showing the progress of dental implantation treatment in patient C.

April 19, 2019

Twenty years ago, the incisor teeth of the lower jaw were shaken due to the shock, but it was maintained to some extent, and then the tooth was extracted due to severe shaking due to chronic periodontitis.The tooth was soaked in NaOCl for 3 hours to remove the endotoxin leached from the tartar and the root, and 2 Stored for week.

12 is a photograph of a tooth from which calculus and endotoxin were removed by extraction.

May 2, 2019

Immediately before tooth re-implantation, the tooth was removed and cleaned and applied with GEMMA.

The extraction site is cleaned after the sofa, applied with GEMMA, and then inserted into the previously prepared tooth extraction, and the tooth on the left and right of the re-implanted tooth is hung together with a metal mesh and a bridge is applied to fix it with a super bond. The tooth surface was ground to match the color and shape, and the procedure took about 1 hour and 20 minutes.

FIG. 13 is an X-ray picture of the teeth of patient C before (a) and immediately after (b) a tooth implantation procedure using GEMMA on May 2, 2019, two weeks after extraction.

May 10, 2019

14 is a tooth X-ray photograph of patient C on May 10, 2019 after a week of tooth implantation using GEMMA. According to this, it was confirmed that in just one week, the teeth were more white and the teeth were fixed well compared to immediately after tooth transplantation.

FIG. 15 is a photograph of patient C before (a), after tooth extraction (b), and after (c) a tooth implantation procedure using GEMMA.

Comparative Experimental Example One: Dental implant in patient D Clinical example

May 11, 2016

After extraction, it was put in an aqueous solution of NaOCl to dissolve and sterilize organic matter, and then soaked in saline. After coating the tooth extraction and the part with the Vital of Comparative Preparation Example 1, the tooth was removed from the saline solution and placed, and the treatment was completed by fixing the tooth after 5 minutes. The use of treatment teeth was prohibited for 6 months after transplantation. After 6 months, the implantation was made available and the implantation was notified.

Comparative Experimental Example 2: Dental implantation in patient E Clinical example

17 November 2017

The tooth extraction was sterilized by immersing in NaOCl aqueous solution, and then immersed in saline solution for 7 days. After coating the tooth extraction and the part with the Polybone of Comparative Preparation Example 2, the tooth was removed from the saline solution and placed, and the tooth was fixed after 10 minutes to complete the treatment.

November 18, 2017

The day after the tooth implantation, the tooth was not fixed and he complained of pain.

2017. 12. 17

One month after tooth transplantation, it was confirmed that there was no treatment effect, and the polybone was scraped and re-operated in the same manner as in Example 1 using Gemma, but the roots were not fixed to the jaw bone for 6 months after the re-operation.

Claims (6)

Calcium phosphate;
Gypsum (calcium sulfate);
Calcium carbonate (CaCO ₃ );
Silicon dioxide (SiO ₂ );
Aluminum oxide; And
Calcium zirconia complex; periodontal bone cement composition comprising a. The method of claim 1,
The periodontal bone cement composition.
Based on 100 parts by weight of calcium phosphate,
30 to 40 parts by weight of gypsum (calcium sulfate);
Calcium carbonate (CaCO ₃ ) 9 to 12 parts by weight;
Silicon dioxide (SiO ₂ ) 0.5 to 2.5 parts by weight;
0.5 to 1.5 parts by weight of aluminum oxide; And
3 to 4.5 parts by weight of calcium zirconia complex; periodontal bone cement composition comprising a. The method of claim 1,
The periodontal bone cement composition,
Perphosphoric acid; And
Distilled water or saline; periodontal bone cement composition, characterized in that it further comprises. The method of claim 1,
The calcium phosphate is β-tricalcium phosphate (β-TCP), dicalcium phosphate dihydrate (CaHPO _{4 ·} · 2H ₂ O, DCPD), tetracalcium dihydrogen phosphate (Ca ₄ H ₂ P ₆ O ₂₀ , TCHP) , Hydroxyapatite (HAp), octacalcium phosphate (OCP), α-tricalcium phosphate (α-TCP) and tetra calcium phosphate (TTCP), characterized in that at least one selected from the bone cement composition for periodontal periodontal. The method of claim 1,
The gypsum (calcium sulfate) is a bone cement composition for periodontal, characterized in that at least one selected from hemihydrate gypsum (calcium sulfate hemihydrate), dihydrate gypsum (calcium sulfate dehydrate), and anhydrous gypsum (calcium sulfate anhydrate). The method of claim 1,
The periodontal bone cement composition is a periodontal bone cement composition, characterized in that used for natural tooth implantation or tooth decay treatment.

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