KR20200048141A - Composition for for improving acne skin or inhibiting sebum secretion containing extract of ailanthi radicis cortex - Google Patents

Abstract

Disclosed in the present invention is a composition for alleviating acne containing an Ailanthus altissima bark extract as an active component. Specifically, since the composition for alleviating acne according to the present invention contains the Ailanthus altissima bark extract as an active component, the composition exhibits an excellent effect of inhibiting sebum secretion, thereby exhibiting an excellent effect of alleviating acne-prone skin or alleviating seborrheic skin.

Description

Composition for improving acne skin or inhibiting sebum secretion containing low-root white blood extract as an active ingredient {COMPOSITION FOR FOR IMPROVING ACNE SKIN OR INHIBITING SEBUM SECRETION CONTAINING EXTRACT OF AILANTHI RADICIS CORTEX}

The present invention relates to a composition containing a low muscle white skin extract as an active ingredient, and more particularly, to a composition for improving acne skin, suppressing sebum secretion or seborrheic skin containing the low muscle white skin extract as an active ingredient. will be.

Common acne is a common skin disease that 80% of Koreans experience. Recently, as puberty is getting faster, even in the fifth and sixth grade of elementary school, there is a case of finding a dermatologist with acne. Women usually appear in their late teens to early 20s, and males in their late teens to early 20s. Most of them disappear within a few years without special treatment, but in many cases, it is necessary to develop technology for acne treatment.

Acne is a condition that causes chronic inflammation of the sebaceous glands, and is mainly seen on the face, neck, and chest where sebum is secreted a lot. Acne is divided into normal acne (image acne), pimple acne, premenstrual acne, acne before puberty, neonatal acne, infant acne, childhood acne, occupational acne, and keloid acne.

Common acne (acne vulgaris) has several causes, and the most common is sex hormone. The increase in sex hormone is increased by various factors including puberty, which causes excessive sebum secretion and clogging of the pores due to abnormal detachment of keratin.

The sebaceous hypersecretion is caused by various causes, and most of all, the sebaceous gland cells are activated by the amount of dihydrotestosterone (DHT), one of the hormones involved in promoting sebum secretion in the activity of the sebaceous glands. Is over-secreted. That is, testosterone is converted into dihydrotestosterone by 5α-reductase in the skin or sebaceous gland, thereby activating sebaceous gland cells to promote differentiation, thereby over-secreting sebum in the sebaceous gland to cause acne ( J. Invest Dermatol 105: 209-214 Diane etc).

In addition to simple sebum hypersecretion, acne, which is a skin problem, is exacerbated by the skin's microscopic inflammatory reaction. Looking at the process of acne, excessive sebum accumulates in the hair follicles, activating acne bacteria and causing inflammation.

In addition, excessive secretion of sebum is a disease or skin trouble of the sebaceous glands, causing oily coating, crusts or scales on the skin, seborrheic dermatitis, also called seborrheic eczema. Cause

The treatment of acne includes oral antibiotics and retinoids, external medicine application, cotton extraction, chemical peeling, and antibiotics such as tetracycline, clindamycin, and erythromycin. However, there is a problem in that the therapeutic effect is reduced due to side effects or antibiotic resistance in long-term use.

In order to solve these problems, several cosmetic compositions for improving acne skin, which contain natural fragrance substances such as tea tree oil or rosemary oil as an active ingredient, have been proposed. However, none of them have shown satisfactory acne improvement effects.

On the other hand, low-rooted white skin refers to the bark of a leather tree ( Ailanthus altissima ), and it is used for heat removal, humidity control, shoveling, small bowel, insecticidal, and wetland (渗濕 止 帶), It is known as a medicinal herb that has the effect of breaking down.

Republic of Korea Patent Publication No. 10-2008-0093663 Republic of Korea Patent Publication No. 10-2014-0060476

An object of the present invention is to provide a composition having an effect of improving acne skin, inhibiting sebum secretion, or improving seborrheic skin by containing a low muscle white skin extract as an active ingredient.

In order to achieve the above object, an embodiment of the present invention provides a composition for improving acne skin containing a low-root white blood extract as an active ingredient.

In addition, another embodiment of the present invention provides a composition for inhibiting sebum secretion containing a low-root white blood extract as an active ingredient.

In addition, another embodiment of the present invention provides a composition for improving seborrheic skin containing a low-root white blood extract as an active ingredient.

The composition for improving acne according to the present invention exhibits excellent sebum secretion inhibiting effect by containing a low muscle white skin extract as an active ingredient, and thus can exhibit excellent acne skin improvement or seborrheic skin improvement effect.

1 is a graph showing the sebum secretion inhibitory effect test results according to Test Example 1.

Hereinafter, the present invention will be described in detail.

The present invention, in one aspect, provides a composition for improving acne skin containing a low-root white blood extract as an active ingredient.

In another aspect, the present invention provides a composition for inhibiting sebum secretion containing a low-root white blood extract as an active ingredient.

In another aspect, the present invention provides a composition for improving seborrheic skin, which contains a low muscle white skin extract as an active ingredient.

The low muscle white skin is a bark of a leather tree ( Ailanthus altissima ), and is not particularly limited, and any low muscle white skin that can be purchased normally can be used.

According to one embodiment of the present invention, the low root white blood extract may be an extract extracted using an extraction solvent selected from water, a lower alcohol having 1 to 4 carbons, or a mixed solvent thereof, and preferably, the extraction solvent It may be 99.5% (v / v) or more of anhydrous ethanol.

In addition, according to an embodiment of the present invention, the low-root baekpi extract may be contained in an amount of 0.001 to 10% by weight based on the total weight of the composition.

Specifically, the content of the low-root white blood extract based on the total weight of the composition is 0.001% by weight or more, 0.005% by weight or more, 0.01% by weight or more, 0.03% by weight or more, 0.05% by weight or more, 0.07% by weight or more, 0.1% by weight Or more, 0.3% or more, 0.5% or more, 0.7% or more, 1% or more, 2% or more, 3% or more, 4% or more, 5% or more, 6% or more, 7% or more Or more, 8% or more, or 9% or more, and 10% or less, 9% or less, 8% or less, 7% or less, 6% or less, 5% or less, 4% or less , 3% or less, 2% or less, 1% or less, 0.7% or less, 0.5% or less, 0.3% or less, 0.1% or less, 0.07% or less, 0.05% or less, 0.03% or less , 0.01% by weight or less or 0.005% by weight or less.

If the content of the low root white skin extract is less than 0.001% by weight based on the total weight of the composition, the effect of inhibiting sebum secretion is weak, and if it is more than 10% by weight, skin stability or formulation problems may occur.

According to one embodiment of the present invention, the composition may be to inhibit 5α-reductase activity.

According to one embodiment of the invention, the composition may be a pharmaceutical composition.

The pharmaceutical composition may further contain a preservative, a stabilizer, a hydrating agent or an emulsifying accelerator, a pharmaceutical adjuvant such as a salt and / or buffer for controlling osmotic pressure, and other therapeutically useful substances, in addition to the low muscle peel extract. Depending on the method, it can be formulated into various oral dosage forms or parenteral dosage forms.

The oral administration agent, for example, tablets, pills, hard and soft capsules, liquids, suspensions, emulsifiers, syrups, powders, powders, granules, granules, pellets, etc., these formulations are surfactants in addition to the active ingredient , May contain diluents (e.g. dextrose, sucrose, mannitol, sorbitol, cellulose and glycine), lubricants (e.g. silica, talc, stearic acid and its magnesium or calcium salts and polyethylene glycols) have. Tablets may also contain binders such as magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose and polyvinylpyrrolidine, and optionally starch, agar, alginic acid or sodium salts thereof. It may contain pharmaceutical additives such as disintegrants, absorbents, colorants, flavoring agents, and sweetening agents. The tablets can be prepared by conventional mixing, granulating or coating methods.

In addition, the parenteral dosage form may be a transdermal dosage form, for example, injections, drops, ointments, lotions, gels, creams, sprays, suspensions, emulsions, suppositories, patches, etc. It may be, but is not limited thereto.

The pharmaceutical composition may be administered parenterally, rectal, topical, transdermal, subcutaneous, and the like. Determination of the dosage of the active ingredient is within the level of a person skilled in the art, and the daily dosage of the drug varies depending on various factors such as the degree of progression, onset time, age, health condition, and complications of the subject to be administered. In general, the composition may be administered by dividing the composition 1 μg / kg to 200 mg / kg, preferably 50 μg / kg to 50 mg / kg, 1 to 3 times a day, and the dosage may be in any way. It is not intended to limit the scope of the present invention.

According to one embodiment of the invention, the composition may be a cosmetic composition.

The cosmetic composition may contain a cosmetic or dermatologically acceptable medium or base. These are all formulations suitable for topical application, e.g. solutions, gels, solids, dough anhydrous products, emulsions, suspensions, microemulsions, microcapsules, microgranules, or ionic (liposomes) obtained by dispersing an oil phase in an aqueous phase, and It can be provided in the form of a non-ionic vesicle dispersant, or in the form of a cream, skin, lotion, powder, ointment, spray or conceal stick. These compositions can be prepared according to conventional methods in the art. The cosmetic composition according to an embodiment of the present invention may also be used in the form of an aerosol composition further containing a propellant compressed in the form of a foam.

The cosmetic composition is not particularly limited in its formulation, and may be appropriately selected according to the purpose. For example, skin lotion, skin softener, skin toner, lotion, milk lotion, moisture lotion, nutrition lotion, massage cream, nutrition cream, moisture cream, hand cream, foundation, essence, nutrition essence, pack, soap, cleansing foam, Cleansing lotions, cleansing creams, cleansing water, powders, body lotions, body creams, body oils, body cleansers and body essences can be prepared in the form of formulations.

When the formulation of the present invention is a paste, cream or gel, animal fibers, plant fibers, wax, paraffin, starch, tracant, cellulose derivatives, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component. Can be.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in particular, in the case of a spray, additionally chlorofluorohydrocarbon, propane / Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a solution or emulsion, a solvent, solvating agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or sorbitan.

When the formulation of the present invention is a suspension, liquid diluents such as water, ethanol or propylene glycol as carrier components, suspensions such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, microcrystalline Cellulose, aluminum metahydroxide, bentonite, agar or trakant, etc. can be used.

When the formulation of the present invention is a surfactant-containing cleansing, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivatives, methyltaurate, sarcosinate, fatty acid amide as a carrier component Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linoline derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

The cosmetic composition may further include a functional additive and a component included in a general cosmetic composition in addition to the low muscle white skin extract. The functional additive may include a component selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymer polysaccharides, sphingo lipids, and seaweed extract.

In addition to the above-mentioned functional additives, the composition may contain components included in a general cosmetic composition, if necessary. Other ingredients included include oils and fats, moisturizers, emollients, surfactants, organic and inorganic pigments, organic powders, UV absorbers, preservatives, fungicides, antioxidants, plant extracts, pH adjusters, alcohols, pigments, flavors, blood circulation Accelerators, cooling agents, limiting agents, purified water, and the like.

According to one embodiment of the invention, the composition may be a food composition.

The food composition may be a liquid or solid dosage form, for example, various foods, beverages, gums, teas, vitamin complexes, health supplements, etc., and may be used in the form of powders, granules, tablets, capsules, or beverages have. The food composition of each formulation can be formulated by appropriately selecting the ingredients commonly used in the field other than the low-root white blood extract according to the formulation or purpose of use without difficulty, and synergistic effects may occur when applied simultaneously with other raw materials. have.

There are no particular limitations on the liquid components that can be included in addition to the low-root white blood extract, and may include various flavoring agents or natural carbohydrates, etc. as additional components, such as ordinary beverages. Examples of the natural carbohydrates include disaccharides such as monosaccharides, glucose and fructose, fructoses such as maltose and sucrose, sugars such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol. As the above-mentioned flavoring agents, natural flavoring agents (taumatine, stevia extract (for example, rebaudioside A, glycyrrhizine, etc.) and synthetic flavoring agents (for example, saccharin, aspartame, etc.) can be advantageously used. have. The ratio of the natural carbohydrate may be generally about 1 to 20 g per 100 ml of the composition disclosed herein, and about 5 to 12 g in one aspect.

The food composition is, in one aspect, various nutrients, vitamins, minerals (electrolytes), flavoring agents such as synthetic and natural flavoring agents, colorants and enhancers (cheese, chocolate, etc.), pectic acid and salts thereof, alginic acid and salts thereof, Organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohol, carbonic acid used in carbonated beverages, and the like. In other aspects it may include flesh for the manufacture of natural fruit juices and vegetable drinks. The components can be used independently or in combination. The ratio of the additive may vary, but is generally selected from about 0.001 to 20 parts by weight per 100 parts by weight of the composition disclosed herein.

Hereinafter, the contents of the present invention will be described in more detail through examples and test examples. However, these examples and test examples are only provided to understand the contents of the present invention, the scope of the present invention is not limited to these examples and test examples, and modifications and substitutions commonly known in the art And insertion, and the like is also included in the scope of the present invention.

[Example 1] Preparation of low-root baekpi extract

100 ml of anhydrous ethanol was added to 100 g of Ailanthus altissima bark purchased from Plant Extract Bank (Daejeon, South Korea), and an extractor with reflux cooler (HB 4 basic, IKA) was used for 2 hours at 80 ℃. During warming extraction. After filtering the extract with filter paper (Whatman No.2, Whatman 社), the remaining residue is extracted once more in the same manner as above, and the obtained extract is used at 40 ℃ using a reduced pressure concentrator (Rotavapor, Buchi 社). After concentration under reduced pressure, freeze-drying to obtain a dry extract of low-root white blood.

[Test Example 1] Sebum secretion inhibitory effect

In order to evaluate the effect of inhibiting sebaceous secretion of the low muscle white blood extract of the present invention, an in vitro model of an environment similar to that of human furus gland was used by using sebaceous gland cells and keratinocytes together. Specifically, 3.75x10 ⁴ dogs were each 6.0x10 ⁴ each inoculated with human HaCaT keratinocytes (ATCC, VA, USA) and sebaceous gland cells (Cellprogen, CA, USA) of the person in a 24-well culture plate (well). After inoculation, it was maintained for 24 hours to allow cells to adhere to the bottom of the culture plate. At this time, 10% of fetal bovine serum (JRH Bioscience, Tokyo, Japan) was added to DMEM medium (Invitrogen, Carlsbad, CA), penicillin 100mg / ml, streptomycin 100mg / What added ml (all of the above reagents, GIBCO, Milan, Italy) was used. As a stimulating source for causing seborrheic skin inflammation in cells after one day, linoleic acid (50 μM), arachidonic acid (50 μM), and dihydrotestosterone (10 nM) were treated. At the same time, in the experimental group (irritant source + low muscle white skin extract), the low muscle white skin extract of Example 1 was dissolved in dimethyl sulfoxide (DMSO) to make a 1% solution, diluted in DMEM medium, and treated to a final concentration of 50 ppm for one day. After elapsed, the amount of triglyceride produced in the cells was measured using Oil Red O staining.

Oil Red O (Oil Red O) staining method is specifically, after fixing the cells washed with phosphate buffer saline (PBS) with a 3.7% formaldehyde solution for 30 minutes, the fixed cells are washed with PBS three times, 70% ( v / v) washed once with ethanol and stained with 0.4% (v / v) Oil Red O solution for 30 minutes. The stained cells were washed once with 70% (v / v) ethanol and 3 times with PBS, and then dissolved in an oil red O solution stained with isopropanol again, using a spectrophotometer (520 nm). Absorbance was measured at and quantified. The results are shown in FIG. 1.

From the results of FIG. 1, when the stimulation source was treated, the sebum amount increased more than 4 times (about 470%) compared to the control group. Could.

That is, it was confirmed that the low-root white blood extract according to the present invention exhibits an excellent sebum secretion inhibiting effect, and thereby exhibits an excellent acne skin improvement or seborrheic skin improvement effect.

Claims (8)

A composition for improving acne skin, which contains low-root white blood extract as an active ingredient. A composition for inhibiting sebum secretion containing a low muscle white skin extract as an active ingredient. A composition for improving seborrheic skin containing low-root white blood extract as an active ingredient. The method according to any one of claims 1 to 3,
The low-root white blood extract is characterized in that the extract extracted using an extraction solvent selected from water, a lower alcohol having 1 to 4 carbon atoms or a mixed solvent thereof, acne improvement composition. The method of claim 4,
The extraction solvent is 99.5% (v / v) or more of anhydrous ethanol, characterized in that the composition for improving acne. The method according to any one of claims 1 to 3,
The low muscle white skin extract is characterized in that it is contained in an amount of 0.001 to 10% by weight based on the total weight of the composition, acne improvement composition. The method according to any one of claims 1 to 3,
The composition is characterized in that to inhibit the activity of 5α-reductase, acne improvement composition. The method according to any one of claims 1 to 3,
The composition is characterized in that the pharmaceutical or cosmetic composition, acne improvement composition.

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