KR20190130251A - Cartridge with capillary structure for lateral flow analysis - Google Patents

Abstract

The present invention relates to a lateral flow analysis cartridge including a capillary structure. According to the present invention, the cartridge employs a sample loading method using the capillary phenomenon to easily load a sample and acquire a reproducible result regardless of the volume of the input sample. Accordingly, the present invention can enhance the accuracy, reproducibility, and convenience.

Description

Cartridge for capillary flow analysis {Cartridge with capillary structure for lateral flow analysis}

The present invention relates to a cartridge for use with a strip for biological sample analysis.

The development of diagnostic methods and diagnostic tools by qualitatively or quantitatively measuring trace substances such as nucleic acids or proteins contained in biological samples such as blood or urine has progressed rapidly over the past three decades and is still rapidly developing. Since the first introduction of radioimmunoassay (RIA) using radioisotopes in the 1950s, enzyme immunoassay (ELISA) was developed and developed in the 70s and 80s.

In the case of protein detection, immunological methods using reactions between antigen antibodies, such as ELISA (Enzyme-linked immunosorbent assay) and immunochromatography methods have been developed and used as products, but it takes a lot of time to process and analyze samples. .

In addition, analysis of the presence of a specific nucleic acid sequence is important in detecting nucleic acid. One of the methods widely used in this analysis is to selectively amplify specific sequences using polymerase chain reaction and then use hybridization such as gel electrophoresis, Southern blot and Northern blot. However, this method takes a long time to work and is not only sensitive but also influenced by external conditions such as the hybridization time, the temperature of the hybridization, the composition of the composition used for the hybridization, and moreover it is optimal to obtain accurate test results. There are problems such as repeated experiments and specially trained specialists to find the conditions.

In particular, the detection of nucleic acids requires the development of a method that is quick, reproducible, sensitive and highly specific in determining accuracy such as the presence or absence of a specific disease. For example, detection of specific nucleic acids is important in the medical field, such as in the diagnosis and treatment of diseases, for example in the diagnosis of certain cancers, such as in the diagnosis of cancers such as cervical cancer, and thus can be used as an alternative to conventional methods. In addition, the development of a rapid nucleic acid detection system is required.

A representative method for detecting recently developed proteins or nucleic acids is a lateral flow assay based on chromatographic methods. The lateral flow analysis method is widely used in various fields such as pregnancy diagnosis, cancer diagnosis, the presence of other specific proteins or genes or microbial detection.

Korean Patent No. 1115014 relates to a chromatography system for nucleic acid detection, and discloses a strip comprising a support, a development medium, a sample pad and an absorption pad. When the sample pad is loaded with the quantitative sample, the chromatographic principle moves the sample laterally along the development medium, and certain components in the sample bind to the trapper immobilized on the development medium and the rest to the absorbent pad. It is the principle of movement. In such conventional strips, the sample is loaded directly into the sample pad, so that the exact amount of sample loaded is critical to the reproducibility of the result. Loading directly onto the sample pad is not easy to change the sample volume. Therefore, the experimenter was inconvenient to load the sample pad accurately weighed in microliters on the sample pad, and the amount of the sample to be input may vary each time, which may cause an error in the measurement result. If it is desired to change the amount, this will inevitably change the configuration of the strip and the cartridge is required to improve.

The present invention is to solve the above-mentioned problems, and to provide a cartridge for side flow analysis capable of convenient and efficient sample loading.

In one aspect the present disclosure provides a cartridge for lateral flow analysis. In one embodiment the cartridge according to the present invention comprises a base member; And a cover member engaged with the base member, wherein the base member includes a strip receiving portion for receiving a strip used for the lateral flow analysis, and a sample well formed at a position extending from one end of the strip receiving portion. And the cover member includes a measurement window formed at a portion corresponding to the strip receiving portion and a sample introduction hole formed at a portion corresponding to the sample well, when the cover member is filled with the base member, and the base member or the cover member. Or the base member and the cover member include a capillary structure, wherein the capillary structure formed on the cover member is formed on a lower surface adjacent to the sample inlet of the cover member, and the capillary structure formed on the base member is the sample well. Can be formed on.

In one embodiment according to the present disclosure, the capillary structure further comprises an extension extending from the capillary structure. In another embodiment according to the present invention, an air groove is formed at one end of the capillary structure, and in one embodiment, the air groove may be at least the same length as the width of the strip received in the strip receiving portion. The capillary structure according to the present application further comprises an extension extending from the capillary structure, wherein the air groove is formed between the capillary structure and the extension.

In one embodiment according to the present disclosure, the capillary structure is formed with one or more capillary structures that can cause capillary action. In one embodiment according to the present invention, when the capillary structure is formed on both the cover member and the base member, when capturing the cover member and the base member, each capillary structure formed on each capillary structure is formed to cross each other. .

In one embodiment according to the present disclosure, the capillary structure may take various forms and / or structures as long as it can cause a capillary phenomenon, for example, may be triangular, semicircular or rectangular in shape.

In one embodiment according to the present invention, when the capillary structure is formed on only one of the base member or the cover member, the base member or the cover member on which the capillary structure is not formed has a structure capable of receiving the shape of the capillary structure. do.

In another embodiment according to the present invention, the capillary structure is formed in the cover member, the capillary structure is in the shape of a triangle, the base member is inclined surface that can receive the triangular shape of the portion adjacent to the strip receiving portion It is formed in the sample well.

In another embodiment according to the present invention the capillary structure is formed on the base member, the capillary structure is in the shape of a triangle, the cover member is formed on the cover member inclined surface that can accommodate the triangular shape.

In one embodiment according to the present disclosure, the base member and the cover member included in the cartridge of the present application further include a fastening means.

In one embodiment according to the present application, the cover member included in the cartridge of the present application further includes an air window when the width of the side window is smaller than the width of the strip accommodated in the strip receiving portion, and the air window is in the direction of the sample inlet. Is formed at a portion adjacent to one end of the measurement window.

In one embodiment according to the present application, the lateral flow analysis cartridge of the present application further comprises a measurement window cover that can open and close the measurement window.

The lateral flow analysis cartridge according to the present invention employs a sample loading method using a capillary phenomenon, and the convenience is remarkably improved.

In addition, the sample loading through the capillary phenomenon, a certain amount is loaded into the sample pad of the strip to reduce the measurement error by the user without accurately weighing the amount of the sample into the sample well up to several microliters unit Not only can the result be obtained, but also the amount of sample input can be easily changed, which is convenient and economical since there is no need to change the composition of the strip and the cartridge.

1A is an exploded perspective view of a lateral flow analysis cartridge including a lateral flow strip according to an embodiment of the present disclosure, in which a capillary structure having a triangular shape and a structure corresponding thereto are formed on a lower surface of a cover member.
FIG. 1B is an exploded perspective view of a lateral flow analysis cartridge including a lateral flow strip according to another embodiment of the present disclosure, in which a capillary structure having a rectangular shape and a structure corresponding to the base member are formed on the bottom surface of the cover member; .
1C is an exploded perspective view of a lateral flow analysis cartridge including a lateral flow strip according to another embodiment of the present disclosure, in which a structure corresponding to the semicircular capillary structure and the base member is formed on the bottom surface of the cover member; .
1D is an exploded perspective view of a lateral flow analysis cartridge including a lateral flow strip according to another embodiment of the present invention, wherein the capillary structures having triangular shapes are formed on the cover member and the base member, respectively.
Figure 2 is an exploded perspective view of a lateral flow analysis cartridge, including a lateral flow strip according to another embodiment of the present invention, the air groove is formed on both sides of the cover member.
FIG. 3A is an exploded perspective view of a lateral flow analysis cartridge, including a lateral flow strip, according to another embodiment of the present disclosure, showing that the intervals forming each capillary of the capillary structure formed in the cover member are not parallel.
FIG. 3B is an exploded perspective view of a lateral flow analysis cartridge, including a lateral flow strip, according to another embodiment of the present disclosure, showing that the intervals forming each capillary of the capillary structure formed in the cover member are not parallel.
4A is an external perspective view of a state in which the base member and the cover member are joined.
4B to 4E are enlarged cross-sectional views of the AA line of FIG. 4A and a part thereof.
4B shows that the former is higher in height with the bottom of the sample well of the portion where the strip on the inner surface of the base member is mounted, and the latter is the same in height.
4D shows that the former is higher in height with the bottom of the sample well of the portion where the strip on the inner surface of the base member is mounted, and the latter is the same in height.
5 is a perspective view of a lateral flow strip according to one embodiment of the present disclosure.

Hereinafter, with reference to the accompanying drawings will be described for the lateral flow analysis cartridge of the present invention.

Prior to the description of the invention, the terms or words used in the specification and claims described below should not be construed as limiting in their usual or dictionary meanings. Therefore, the embodiments described in the specification and the drawings shown in the drawings are only one of the most preferred embodiments of the present invention and do not represent all of the technical idea of the present invention, various modifications that can be replaced at the time of the present application It should be understood that there may be equivalents and variations.

Here, in all the drawings for demonstrating embodiment of this application, the thing which has the same function is attached | subjected with the same code | symbol, and the detailed description is abbreviate | omitted.

1 is an exploded perspective view of a lateral flow analysis cartridge including a lateral flow strip according to an embodiment of the present disclosure, in which capillary structures of various shapes are formed in a cover member and / or a base member.

As shown in Figure 1, the lateral flow analysis cartridge of the present application comprises a base member (10); And a cover member 30 engaged with the base member, the base member having a strip receiving portion 18 for receiving a strip used for the lateral flow analysis, and a position extending from one end of the strip receiving portion. And a sample well 12 formed in the sample member, wherein the cover member is formed in a portion corresponding to the sample well and the measurement window 34 formed in a portion corresponding to the strip receiving portion when the base member is filled with the base member. And an inlet 32, wherein the base member or the cover member, or the base member and the cover member include capillary structures 35 and 36, wherein the capillary structure formed on the cover member comprises the sample of the cover member. The capillary structure formed on the lower surface adjacent to the inlet and formed in the base member is formed in the sample well.

Capillary structures 35 and 36 according to the present disclosure may be formed on the lower surface of the cover member 30 and / or on the upper surface of the base member 10 according to the present disclosure. In one embodiment according to the present invention is formed on the cover member 30, in this case is formed to protrude to the lower surface adjacent to the sample inlet, the sample well in the state that the base member 10 and the cover member 30 is fastened It is formed at the position corresponding to (12). In another embodiment according to the invention, it is formed in the base member 10, in which case it is formed in the sample well 12 adjacent to the strip receiving portion 18. In another embodiment according to the present invention, the capillary structure may be formed on both the cover member and the base member. In this case, each capillary structure may cross the capillary structure, which will be described later, when the cover member and the base member are joined. It is formed to be (see FIG. 1D).

The capillary structures according to the invention can also take various shapes, for example in the form of squares, triangles or semicircles. When the capillary structure is formed in only one of the cover member or the base member according to the present application, a structure capable of accommodating the capillary structure is formed in a corresponding portion of the base member or the cover member in which the capillary structure is not formed. That is, when the capillary structure is triangular, the corresponding portions where the capillary structure is not formed are formed with inclined surfaces 14 and 15 to accommodate them (see FIGS. 1A, 2, 3B and 4D), and the capillary structure is rectangular. In this case, a right angle structure is formed in the corresponding portion (see FIG. 1B), and if the capillary structure is a semi-circle, a curved surface capable of accommodating it is formed in the corresponding portion (see FIG. 1C). When the base member and the cover member are collected, the structure capable of accommodating the capillary structure, which is formed in the capillary structure and the member in which the capillary structure is not formed, has a lateral flow described later by a sample introduced into the sample well due to capillary action. It is positioned so that it can be moved to the sample pad of the strip. When the capillary structure is formed in the base member, the sample well in which the capillary structure is located takes the shape of the right descending inclined surface, and the sample can be introduced into the capillary structure by gravity when the sample is introduced (see FIGS. 4D and 4E). In this case a shape 14 of the capillary structure, for example a structure 14 capable of receiving a descending inclined surface, is formed at a corresponding position of the cover member, the structure 14 being the shape of the capillary structure 36, eg For example, it may serve to adjust the sample inflow amount into the sample pad through the capillary structure according to the degree of close contact with the inclined surface.

1 to 4, the capillary structures 35 and 36 according to the present disclosure are formed with one or more capillary structures capable of inducing capillary phenomenon, and each capillary structure is spaced apart to induce capillary phenomenon, The spacing between each capillary structure may be parallel (see FIGS. 1 to 2) or may not be parallel (see FIG. 3) as long as it can cause capillary action.

In the capillary structure according to the present invention, when the base member and the cover member are squeezed, all or a part of the sample loaded in the sample well is in contact with each other, and when the sample is in contact with the sample, the movement of the sample through the capillary structure is started. Therefore, various shapes or structures that can induce this phenomenon can be employed as the capillary structure. In one embodiment, having a structure as shown in FIGS. 1 to 3 or having a lower surface of the capillary structure includes one or more channel structures or penetrating tubular structures (not shown) in communication with the sample wells. It is not.

2, 3 and 4A, a cartridge according to the present disclosure may include an air groove 40. The air groove may be formed in the cover member or the base member, or the cover member and the base member, and may be formed at the position where the capillary structure ends, and when the extension part 37 is described later, the capillary structure may be formed between the extension part and the extension part. Can be formed on. When the air groove 40 is the base member and the cover member, when the capillary structure is in contact with a portion of the sample pad to form a closed space in the capillary structure, the air flows into the capillary phenomenon occurs smoothly To do so (see Figure 4b).

Furthermore, the capillary structure according to the present application may further include a capillary structure extension part 37 formed at a position extending therefrom, and the extension part may be a guide that guides the flow of the sample according to the capillary phenomenon to the sample pad of the strip to be described later. Can work. Capillary structure extension 37 may also act as a support for securing air inlet. Specifically, when the base member and the cover member are collected, the sample pad is pressed by the capillary structure at the site where the capillary structure and the sample pad are in contact, thereby forming a closed space in the capillary structure, which may result in the capillary phenomenon. The capillary extension 37 may function to prevent this. Thus, as long as it performs this function, the capillary structure extension 37 can take a variety of sizes and shapes, and in one embodiment the capillary extension 37 is spaced from, or connected to, the capillary structure 36, It is formed in a direction parallel to the capillary structure formed in the capillary structure, less than or equal to the height of the capillary structure.

The cover member 30 according to the present application covers or opposes the upper end of the base member when the base member 10 is fastened, and the sample inlet 32 formed in the cover member is fastened to the base member, and is well-sampled. It is formed so as to oppose or perpendicular to (12). In addition, the measurement window 34 positioned on the cover member is formed at a position where the portion of the medium for development 22 of the strip accommodated in the strip receiving portion 18 can be observed while being engaged with the base member.

The cartridge herein may further comprise an air window 38. 1, 2 and 3, the air window is to prevent the capillary flow is interrupted due to the close contact of the liquid absorbed in the sample pad and the cover member. If the measuring window is formed to the same extent as the width of the strip, the air window may be omitted. The air window may be formed at a position suitable for the discharge of air present in the sample flow, in one embodiment corresponding to the sample pad of the strip accommodated between the sample inlet and the measurement window, in particular in the strip receptacle. It can be located between the position of the image and the measurement window.

1, 2, and 4, the sample well 12 according to the present application is positioned to face or perpendicular to the sample inlet 32 while the base member and the cover member are fastened. In one embodiment of the present application, the protrusion dam 13 is further provided to contain a sample. In another embodiment of the present application, the sample well has an upwardly inclined surface 15 and a protruding dam 13 facing toward the strip receiving portion, and the protruding dam is located at a portion where the upwardly inclined surface 15 is not located. To prevent the sample solution from flowing out. The angle of the ascending slope is formed to accommodate the capillary structure formed by protruding from the cover member to cause a capillary phenomenon.

The size and shape of the sample well 12 may vary, and for example, may be manufactured in consideration of the type and / or amount of the sample used, the size of the capillary structure, and the capillary tube provided in the cover member according to the present disclosure. At least the ends of the structure shall be capable of containing a sample in a capacity that can come into contact with the sample. In one embodiment of the present application, the sample well may be manufactured to a size that can hold about 50 to 300 microliters of sample.

In one embodiment, the sample well of the present application may have a horizontal surface or an inclined shape.

1, 2, 3, and 4, when the base member 10 and the cover member 30 are fastened, the protrusions 16 are interlocked with each other to be interlocked and substantially waterproof. ), It becomes an aerosol proof seal.

One end of each of the base member and the cover member according to the present application may further include a locking step 17 provided to be fastened to each other.

1, 2 and 3, the sample inlet 32 is formed at a position corresponding to the sample well 12, and the sample 300 is transferred to the sample well 12 through the sample inlet 32. Once loaded, the loaded sample is placed in the sample well 12. At least some or all of the capillary structure is in contact with the sample and the movement of the sample is initiated by capillary forces (see arrow portion in FIG. 4B). At this time, the portion of the base member strip is mounted may be the same height or the same as the bottom of the sample well (see Figs. 4b to 4d).

Sample loading method according to the present application using the capillary phenomenon is not a method of loading the sample directly to the sample pad as before, but the volume of the sample 300 to be loaded by loading the sample in the sample well 1 micro as conventional There is no need to accurately weigh up to liters, which can reduce errors due to the lack of accurate quantification, as well as change the amount of sample to be loaded when necessary, which facilitates reproducibility of measurement results and convenience for the user.

The measurement window 34 according to the present invention is a window for measuring / confirming the reaction result, for example, antigen-antibody binding, which occurs as a result of lateral flow analysis in a strip mounted on a strip receiving part, and thus, a measurement window ( 34 is formed in the cover member corresponding to the strip receiving portion.

In one embodiment of the present disclosure the lateral flow analysis cartridge of the present application may further comprise a measurement window cover (not shown). The measuring window cover of the present application serves to protect the strip located in the strip receiving portion. For example, it is possible to prevent damage during transport, to prevent sample input into the strip due to user error, to prevent internal moist phenomena caused by external temperature differences, and to protect the strip from scratches or contamination.

The measurement window cover is attached to the cover member 30, and when not used in an openable and closed manner, the measurement window 34 is covered, but after the lateral flow analysis, the cartridge of the present application is placed in the reader to measure the reaction result. When inserted, it may be a semi-automatic structure that opens in a sliding manner, or it may be a structure that can be opened and closed by hand.

The lateral flow analysis cartridge of the present application may be made of chemically stable synthetic resins and combinations thereof. For example, but not limited to polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyamide, polyester, polyvinyl chloride, polyurethane, polycarbonate, polyvinylidene chloride, polytetrafluoromethylene, polyetherimide and Various plastics of the same thermosetting and thermoplastic and combinations thereof can be prepared using known molding methods. However, the present invention is not necessarily limited thereto, and any material may be used as long as it is suitable for the purpose of the cartridge of the present application.

In addition, the cartridge of the present application can be produced using a variety of known molding methods, such as, but not limited to, injection, rotation, extrusion and / or calendering method depending on the type of material. In one embodiment of the present application, the cartridge of the present application is manufactured by injection-molding acrylic when the cover member and the base member are ABS resin (Acrylonitrile, Butadiene, Styrene), a transparent material is required. Those skilled in the art will be able to select materials and molding methods suitable for the purposes of the present application from various known materials and molding methods for producing the cartridges herein. In addition to the synthetic resin, various additives, for example, a filler, a plasticizer, a stabilizer, a colorant, an antistatic agent, and the like, may be used if necessary to manufacture a cartridge suitable for the purpose of the present application.

The cartridge for lateral flow analysis of the present application may be manufactured in a rectangular shape and may be used in various measuring equipments (readers) capable of accommodating such rectangular shaped cartridges, and sizes may be variously manufactured accordingly. Equipment for which the cartridges of the present application can be used include, for example, but not limited to i-Chroma (Bodytec Med Co., Korea) or RAMP system (Response Biomedical, Canada). It can be tailored to your meter.

Information that can be measured in lateral flow assay cartridges is not limited to this, but is not limited to: high sensitivity C-reactive protein (hsCRP), MicroCRP, HbA1c (glycosylated hemoglobin), microalbumin, prostate specific antigen (PSA), alpha-fetoprotein (AFP), cTnI (Cardiac Troponin I).

The cartridge according to the invention is used for lateral flow analysis, for which a strip is employed. 5 is a perspective view of a lateral flow strip according to an embodiment of the present disclosure. As shown in FIG. 6, the lateral flow analysis strip 20 according to an embodiment of the present disclosure includes a support 28, a development medium 22, a sample pad 26, and an absorption pad 24. The developing medium, the absorbent pad, and the sample pad are located on the support, the sample pad and the absorbent pad are located at both ends of the support, respectively. Respectively positioned between the sample pad and the absorbent pad so as to be in contact with one end of the absorbent pad and one end of the sample pad.

Referring to Figure 1, the development medium, the absorbent pad and the sample pad are located on a support. A lateral flow assay using the strips of the present application is a method of quantitatively or qualitatively measuring a target analyte, eg, a particular nucleic acid or protein, included in a sample 300, for example Sequence-specific hybridization reactions can be performed by chromatography using an oligonucleotide that hybridizes to a sequence of nucleic acid or a nitrocellulose membrane (development medium) in which a specific antibody and / or antigen is bound to a specific position. It is a method for detecting a specific nucleic acid or protein in a sample through an antigen antibody reaction.

As used herein, the term “sample” refers to an analyte compound or composition comprising an analyte, and a sample that can be used in the present invention is a liquid or liquid-like flowable material as it must be able to move the development medium.

As used herein, the term “analyte” is a compound of interest in a sample, also referred to as a target, that includes a nucleic acid. The term “nucleic acid” herein also includes chemical synthetic DNA and RNA, including genome DNA, cDNA and oligonucleotides. In addition, the nucleic acid includes single- or double-stranded, genome DNA, cDNA and oligonucleotides and RNA can be prepared or synthesized according to methods known in the art.

The support 28 constituting the strip herein supports the other components of the strip, and if the support is omitted the development medium, ie the chromatography medium 22 itself, can be the support. The support is usually water insoluble, non-porous and rigid, and usually the same length and width of the other components that develop the sample on the support, such as the sample pad, the development medium, and the absorbent pad, but may be larger or smaller.

The sample pads 26 constituting the strip herein are located at one end of the strip, one end or one end of the sample pad abutting one end of the development medium. In principle, the sample pad is responsible for accepting the sample containing the analyte, having minimal binding capacity with the nucleic acid, and allowing the components of the sample to be easily moved through the chromatography medium.

The sample pad according to the present invention comes into contact with a portion of the capillary structure and / or the capillary structure extension of the cover member, one end of which is described later, while the base member and the cover member constituting the lateral flow analysis cartridge are fastened. In this case, the capillary structure according to the present application only needs to be in contact with the sample at least enough to cause a capillary phenomenon. Due to the capillary phenomenon upon contact with the sample, the sample is absorbed by the capillary structure and the sample begins to flow. That is, the sample entering the capillary structure moves along the capillary structure and the extension part (if present) and is absorbed by the sample pad, and the sample absorbed by the sample pad moves along the development medium and is absorbed by the absorbent pad to prevent movement. It ends. In this process, the analyte in the sample binds to a specific nucleic acid or antibody or antigen bound to the development medium, and the analyte that does not bind continues to move with the sample and is absorbed by the absorption pad.

In the conventional sample input method, the sample is loaded directly onto the sample pad, and the flow generated within the same time due to gravity when there is a change in the amount of the sample according to the error according to the experimenter or even the same experimenter may occur during the experiment ( Due to variations in the amount of flow, it is difficult to obtain reproducible results. In this case, since the sample is loaded into the sample pad through the sample inlet, there is a limit to the amount of sample that can be added according to the size of the sample inlet. When the sample volume is required to increase, the sample volume cannot be increased freely. There is the inconvenience of having to change the cartridge on which the strip is mounted.

On the other hand, unlike the conventional method, the sample is not directly loaded into the sample pad of the strip 20, and the sample loaded into the sample well 12 is absorbed by the sample pad using capillary action.

The sample loading method using the capillary structure according to the present invention not only increases convenience because the sample is moved to the sample pad depending on the absorption performance of the capillary structure, but also accurately adjusts the amount of the sample into the sample well to 1 microliter unit. Without weighing, if a certain amount is loaded into the sample pad and the sample loaded into the sample well satisfies the minimum volume, the measurement of the user error can be reduced, resulting in reproducible results, as well as changing the amount of sample injected. It can be done easily.

On the other hand, the present invention is not limited only to the above-described embodiment, but can be modified and modified within the scope not departing from the gist of the present invention, the technical idea to which such modifications and variations are also applied to the claims Must see

10: base member 12: sample well
13: protruding dam 14, 15: inclined surface, sample flow rate adjusting part
16: uneven protrusion 17a, 17b: locking jaw
18: strip receiver 20: strip
22: development medium 24: absorbent pad
26: sample pad 28: support
30: cover member 32: sample inlet
34: measuring window 35, 36: capillary structure
37: capillary structure extension 38: air window
40: air groove 300: sample

Claims (1)

A cartridge for lateral flow analysis, wherein the cartridge is
A base member; And
A cover member engaged with the base member,
The base member includes a strip receiving portion for receiving a strip used for the lateral flow analysis, and a sample well formed at a position extending from one end of the strip receiving portion.
The cover member includes a measurement window formed in a portion corresponding to the strip receiving portion and a sample inlet formed in a portion corresponding to the sample well when the base member is filled with the base member.
The base member or the cover member, or the base member and the cover member includes a capillary structure, wherein the capillary structure formed on the cover member is formed on a lower surface adjacent to the sample inlet of the cover member and formed on the base member. The capillary structure is formed in the sample well, cartridge for lateral flow analysis.

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